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Pulmonary hemosiderosis

Kenan Barut, Sezgin Sahin, Amra Adrovic, Velat Sen, Ozgur Kasapcopur
Macrophage activation syndrome, a severe complication of systemic juvenile idiopathic arthritis and other inflammatory diseases, represents one of the most important rheumatological emergencies. Delayed diagnosis could lead to life-threatening complications. Pulmonary hemosiderosis has been classically characterized by a triad of anemia, hemoptysis, and lung infiltrates on chest radiogram. Although the majority of patients of pulmonary hemosiderosis are considered idiopathic, secondary hemosiderosis associated with known diseases could be seen...
2017: Case Reports in Pediatrics
Lu-Hong Xu, Rong-Qiong Ou, Bao-Jing Wu, Hai-Yan Wang, Jian-Pei Fang, Wei-Ping Tan
No abstract text is available yet for this article.
February 1, 2017: Journal of Tropical Pediatrics
Ana Madeleine Barrera, Leslie Vargas
Pulmonary ossification is a rare and usually asymptomatic finding reported as incidental in lung biopsies. Similarly, idiopathic pulmonary hemosiderosis is a rare cause of pulmonary infiltrates. We report the case of a 64-year old man with chronic respiratory symptoms in whom these two histopathological findings converged.
December 1, 2016: Biomédica: Revista del Instituto Nacional de Salud
Alina Popp, Ciprian Jurcuţ, Daniel Vasile Balaban, Mihai Șotcan, Kaija Laurila, Mariana Jinga
BACKGROUND: Alveolar hemorrhage is a potentially life-threatening condition which is usually managed by the pulmonologist. When considering its etiology, there is a rare association that sets the disease into the hands of the gastroenterologist. CASE PRESENTATION: We report the case of a 48 year-old female who was admitted to the intensive care unit for severe anemia and hemoptysis. On imaging, diffuse pulmonary infiltrates suggestive of alveolar hemorrhage were detected and a diagnosis of pulmonary hemosiderosis was made...
December 2016: Journal of Gastrointestinal and Liver Diseases: JGLD
Dilek Doğruel, Ayşe Erbay, Nalan Yazici, Alev Arslan, Bermal Hasbay Biçen
Idiopathic pulmonary hemosiderosis is primarily a disorder of childhood, which is characterized by hemoptysis, iron deficiency anemia, and diffuse parenchymal infiltrates on chest x-ray secondary to recurrent attacks of alveolar hemorrhage. It can be diagnosed by showing hemosiderin laden macrophages in bronchoalveolar lavage fluid after other specific causes of diffuse alveolar hemorrhage are definitely excluded. A 5-year-old male patient was admitted to our clinic with sudden-onset pallor during iron therapy given for anemia...
January 2017: Journal of Pediatric Hematology/oncology
Gabriel Thornton, Mona Alotaibi
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
Hiroyuki Wakiguchi, Shouichi Ohga
  Liposteroid, a lipid emulsion containing dexamethasone, was developed in Japan. This drug is effective against rheumatoid arthritis, and has fewer side effects than dexamethasone. Moreover, at high dosage, liposteroid has been effectively used for the treatment of macrophage activation syndrome, because the lipid emulsions are easily taken up by phagocytes, and are retained in macrophages. Its anti-inflammatory effect was found to be 2-5 times higher than that of dexamethasone in arthritis and granuloma rat models...
2016: Nihon Rinshō Men'eki Gakkai Kaishi, Japanese Journal of Clinical Immunology
Mustafa Erkoçoğlu, Ersoy Civelek, Can Naci Kocabaş
Idiopathic pulmonary hemosiderosis (IPH) is a rare disorder that should be considered in the differential diagnosis of patients with hemoptysis, recurrent alveolar hemorrhage, dyspnea and iron deficiency anemia (IDA). The frequent association of autoimmune disorders with IPH and a favorable response to steroids suggest the presence of an underlying immune disorder. Here we present a case of a patient with cough, fever, and cyanosis who was also diagnosed with IPH and concurrent selective immunoglobulin A deficiency...
October 2016: Pediatric Pulmonology
Shuhan Peng, Yunbin Xiao, Jinwen Luo, Renwei Chen, Peng Huang, Pingbo Liu, Xicheng Deng
Pulmonary hemosiderosis is a disorder with unknown cause and characterized by hemosiderin appreciation in alveolar interstitium from decomposed hemoglobin following alveolar capillary bleeding, which finally leads to pulmonary fibrosis. It can be divided into primary and secondary types in terms of its etiology. While primary types are related to autoimmunity, secondary types can be associated with cardiovascular and pulmonary causes such as mitral stenosis leading to pulmonary congestion. We report a case of cor triatriatum sinister in a child who presented with hemoptysis as a main clinical manifestation and had been previously diagnosed with idiopathic pulmonary hemosiderosis...
2016: SpringerPlus
Angelique M Leone, Graham J Crawshaw, Michael M Garner, Salvatore Frasca, Iga Stasiak, Karrie Rose, Dan Neal, Lisa L Farina
Egyptian fruit bats (Rousettus aegyptiacus) are one of many species within zoologic collections that frequently develop iron storage disease. The goals of this retrospective multi-institutional study were to determine the tissue distribution of iron storage in captive adult Egyptian fruit bats and the incidence of intercurrent neoplasia and infection, which may be directly or indirectly related to iron overload. Tissue sections from 83 adult Egyptian fruit bats were histologically evaluated by using tissue sections stained with hematoxylin and eosin, trichrome, and Prussian blue techniques...
March 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
Kangkang Yang, Lin Dong, Jie Ding, Haiyan Li
OBJECTIVE: To investigate the etiology and clinical manifestation of hemoptysis in children. METHOD: A retrospective analysis was performed for 106 cases of hemoptysis who were admitted to The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University from January 2005 to December 2014.The clinical information including laboratory tests and image data were collected and analyzed. RESULT: A total of 106 patients (50 males and 56 females) were identified...
February 2016: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
Hisanori Fujino, Yoshihiko Takano, Ako Tatsumi, Shinya Hida, Shinichi Sumimoto
No abstract text is available yet for this article.
January 2016: Pediatric Infectious Disease Journal
Chen Xi-Yuan, Sun Jin-Ming, Huang Xiao-Jun
BACKGROUND: Idiopathic pulmonary hemosiderosis (IPH) is a rare disorder of unknown etiology which can cause diffuse alveolar hemorrhage (DAH) . IPH is found primarily in children. In adults, however, it is extremely rare. A systematic review was applied to identify the details of IPH in adults. METHODS: Articles of English or Chinese language published between 2000 and 2015 were included. Data were extracted on the clinical features, examinations, treatments, and clinical outcome...
December 21, 2015: Clinical Respiratory Journal
A Potalivo, L Finessi, F Facondini, A Lupo, C Andreoni, G Giuliani, C Cavicchi
Idiopathic pulmonary hemosiderosis (IPH) is a rare cause of alveolar hemorrhage in children but should be considered in children with anemia of unknown origin who develop respiratory complications. It is commonly characterized by the triad of recurrent hemoptysis, diffuse parenchymal infiltrates, and iron-deficiency anemia. Pathogenesis is unclear and diagnosis may be difficult along with a variable clinical course. A 6-year-old boy was admitted to the hospital with a severe iron-deficiency anemia, but he later developed severe acute respiratory failure and hemoptysis requiring intubation and mechanical ventilation...
2015: Case Reports in Pulmonology
Ahmad A Mourad, Hetu Parekh, Sami L Bahna
Anemia can be caused by, or be associated with, many clinical conditions, including pulmonary diseases, some of which are rare and can be misdiagnosed. Nontraumatic pulmonary bleeding may be caused by a variety of conditions and results in anemia and pulmonary hemosiderosis, even when it is subtle. The differential diagnosis in such cases is extensive. We present the case of a diagnostic dilemma in a 17-month-old child hospitalized for severe anemia and respiratory distress in which the diagnosis was settled through an allergy/immunology consultation...
November 2015: Allergy and Asthma Proceedings:
Carlo Caffarelli, Francesca Santamaria, Silvia Cesari, Elisa Sciorio, Carlotta Povesi-Dascola, Sergio Bernasconi
Major advances in the conduct of pediatric practice have been reported in the Italian Journal of Pediatrics in 2014. This review highlights developments in allergy, gastroenterology, infectious diseases, neonatology, nutrition, oncology and respiratory tract illnesses. Investigations endorse a need to better educate guardians and improve nutritional management in food allergy. Management of hyperbilirubinemia in neonates and of bronchiolitis have been improved by position statements of scientific societies...
October 31, 2015: Italian Journal of Pediatrics
Hirofumi Watanabe, Mamoru Ayusawa, Masataka Kato, Ami Chou, Akiko Komori, Yuriko Abe, Masaharu Matsumura, Hiroshi Kamiyama, Hiroyuki Izumi, Shori Takahashi
We report the case of a 9-year-old girl with Down syndrome (DS) diagnosed with idiopathic pulmonary hemosiderosis (IPH). Although acute pneumonia complicated by hemolytic anemia was suspected, IPH was finally diagnosed on bronchoscopy. Treatment with prednisolone achieved good clinical response. An association between IPH and DS was not able to be identified, but immunological issues in DS may contribute to the onset of IPH. Recurrent and intractable respiratory symptoms with marked infiltrative shadows in the bilateral lungs and complicated by severe anemia in patients with DS should suggest IPH...
October 2015: Pediatrics International: Official Journal of the Japan Pediatric Society
Hikmet Tekin Nacaroglu, Ozlem Sarac Sandal, Ozlem Bag, Semiha Bahceci Erdem, Ozlem Bekem Soylu, Gulden Diniz, Aysel Ozturk, Demet Can
INTRODUCTION: Idiopathic Pulmonary Hemosiderosis (IPH) is a rare cause of alveolar hemorrhage, which is seen primarily in childhood. Celiac disease is defined as a chronic, immune-mediated enteropathy of the small intestine, caused by exposure to dietary gluten in genetically pre-disposed individuals. Association of IPH and celiac disease is known as Lane Hamilton syndrome. There are limited number of case reports of this syndrome in literature. CASE PRESENTATION: Although there were no growth and developmental delay and gastrointestinal symptoms like chronic diarrhea, chronic constipation, vomiting, abdominal bloating and pain in the two patients with IPH, they were diagnosed with Lane Hamilton Syndrome...
October 2015: Iranian Journal of Pediatrics
Ágnes Papp, Zsolt Bene, Imre Gáspár, Béla Nagy, László Kádár, Tivadar Márialigeti, Andrea Bánfi, György Baktai, György Balla, Béla Nagy
BACKGROUND: A decreased level of vascular endothelial growth factor (VEGF) was previously described in bronchoalveolar lavage fluid (BALF) of adults with interstitial lung diseases (ILD) due to bronchial epithelial cell apoptosis and its proteolytic degradation. Elevated intrapulmonary ferritin was produced by alveolar cells that promoted oxidative injury in such patients. OBJECTIVES: In this study, we analyzed the concentrations of VEGF and ferritin in BALF samples of ILD children and studied the relationship between their levels and the degree of inflammation...
2015: Respiration; International Review of Thoracic Diseases
Takehiko Doi, Shouichi Ohga, Masataka Ishimura, Hidetoshi Takada, Kanako Ishii, Kenji Ihara, Hideyuki Nagai, Toshiro Hara
No abstract text is available yet for this article.
December 2015: European Journal of Pediatrics
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