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https://www.readbyqxmd.com/read/28340257/cd8-positive-t-cell-leukoencephalitis-with-astrocytopathy-clinically-presenting-as-neuromyelitis-optica
#1
Diana L Thomas, Jody Manners, Daniel Marker, Joseph Mettenburg, Geoffrey Murdoch, Bryan Stevens, Guoji Wang, Clayton Wiley
We describe a novel disease entity with the clinical and radiologic presentation of neuromyelitis optica (NMO) and widespread CD8-positive T-cell leukoencephalitis and astrocytopathy. The 59-year-old female patient had a complex 2-year neurological history that included early changes in cognition and memory, progressive lower extremity motor dysfunction, and multimodal sensory involvement. MRI of the spinal cord showed increased T2 signal in the central cord extending from C2 through T4. MRI of the brain showed symmetric radial enhancement in periventricular deep white matter without evidence of demyelinating lesions...
March 16, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/28340224/the-association-of-context-specific-sitting-time-and-physical-activity-intensity-to-working-memory-capacity-and-academic-achievement-in-young-adults
#2
Mireia Felez-Nobrega, Charles H Hillman, Eva Cirera, Anna Puig-Ribera
To examine combined associations between self-reported context-specific sitting time (ST) and physical activity (PA) with working memory capacity (WMC) and academic achievement in a sample of Spanish adults. Undergraduate students ( n = 371; 21 years ± 3 years, 44% female) were recruited from University of Vic-Central University of Catalonia. Participants completed a 54-item survey that assessed socio-demographic variables (e.g. age, gender, academic year), min/week of light (LPA), moderate (MPA) and vigorous (VPA) intensity PA (International Physical Activity Questionnaire), min/day of domain-specific ST (Last 7 days sedentary behavior questionnaire) and academic performance (grade point average)...
March 18, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28335039/brain-temporal-complexity-in-explaining-the-therapeutic-and-cognitive-effects-of-seizure-therapy
#3
Faranak Farzan, Sravya Atluri, Ye Mei, Sylvain Moreno, Andrea J Levinson, Daniel M Blumberger, Zafiris J Daskalakis
Over 350 million people worldwide suffer from depression, a third of whom are medication-resistant. Seizure therapy remains the most effective treatment in depression, even when many treatments fail. The utility of seizure therapy is limited due to its cognitive side effects and stigma. The biological targets of seizure therapy remain unknown, hindering design of new treatments with comparable efficacy. Seizures impact the brains temporal dynamicity observed through electroencephalography. This dynamicity reflects richness of information processing across distributed brain networks subserving affective and cognitive processes...
March 3, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28334687/neurocognitive-status-in-patients-with-newly-diagnosed-brain-tumors-in-good-neurological-condition-the-impact-of-tumor-type-volume-and-location
#4
Philipp Hendrix, Elisa Hans, Christoph J Griessenauer, Andreas Simgen, Joachim Oertel, Julia Karbach
OBJECTIVE: Neurocognitive function is of great importance in patients with brain tumors. Even patients in good neurological condition may suffer from neurocognitive dysfunction that affects their daily living. The purpose of the present study was to identify risk factors for neurocognitive dysfunction in patients suffering from common supratentorial brain tumors with minor neurological deficits. METHODS: A prospective study evaluating neurocognitive dysfunction in patients with a newly-diagnosed brain tumor in good neurological condition was performed at a major German academic institution...
March 18, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28334644/low-level-inorganic-arsenic-exposure-and-neuropsychological-functioning-in-american-indian-elders
#5
Clint R Carroll, Carolyn Noonan, Eva M Garroutte, Ana Navas-Acien, Steven P Verney, Dedra Buchwald
BACKGROUND: Inorganic arsenic at high and prolonged doses is highly neurotoxic. Few studies have evaluated whether long-term, low-level arsenic exposure is associated with neuropsychological functioning in adults. OBJECTIVES: To investigate the association between long-term, low-level inorganic arsenic exposure and neuropsychological functioning among American Indians aged 64-95. METHODS: We assessed 928 participants in the Strong Heart Study by using data on arsenic species in urine samples collected at baseline (1989-1991) and results of standardized tests of global cognition, executive functioning, verbal learning and memory, fine motor functioning, and speed of mental processing administered during comprehensive follow-up evaluations in 2009-2013...
March 18, 2017: Environmental Research
https://www.readbyqxmd.com/read/28334345/effects-of-age-and-gender-on-recall-and-recognition-discriminability
#6
Lisa V Graves, Charles C Moreno, Michelle Seewald, Heather M Holden, Emily J Van Etten, Vedang Uttarwar, Carrie R McDonald, Lisa Delano-Wood, Mark W Bondi, Steven Paul Woods, Dean C Delis, Paul E Gilbert
Objective: Recall and recognition memory abilities are known to decline with increasing age, yet much of the evidence stems from studies that used simple measures of total target recall or recognition. The California Verbal Learning Test-Second Edition (CVLT-II) includes a new measure of recall discriminability that is analogous to recognition discriminability. These discriminability measures yield more thorough assessments of recall and recognition by accounting for intrusion and false positive errors, respectively...
March 17, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28334149/higher-striatal-iron-concentration-is-linked-to-frontostriatal-underactivation-and-poorer-memory-in-normal-aging
#7
Grégoria Kalpouzos, Benjamín Garzón, Rouslan Sitnikov, Carmel Heiland, Alireza Salami, Jonas Persson, Lars Bäckman
In the brain, intracellular iron is essential for cellular metabolism. However, an overload of free iron is toxic, inducing oxidative stress and cell death. Although an increase of striatal iron has been related to atrophy and impaired cognitive performance, the link between elevated iron and altered brain activity in aging remains unexplored. In a sample of 37 younger and older adults, we examined whether higher striatal iron concentration could underlie age-related differences in frontostriatal activity induced by mental imagery of motor and non-motor scenes, and poorer recall of the scenes...
February 23, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28334147/variations-in-acetylcholinesterase-activity-within-human-cortical-pyramidal-neurons-across-age-and-cognitive-trajectories
#8
Monica Janeczek, Tamar Gefen, Mehrnoosh Samimi, Garam Kim, Sandra Weintraub, Eileen Bigio, Emily Rogalski, M-Marsel Mesulam, Changiz Geula
We described an extensive network of cortical pyramidal neurons in the human brain with abundant acetylcholinesterase (AChE) activity. Emergence of these neurons during childhood/adolescence, attainment of highest density in early adulthood, and virtual absence in other species led us to hypothesize involvement of AChE within these neurons in higher cortical functions. The current study quantified the density and staining intensity of these neurons using histochemical procedures. Few faintly stained AChE-positive cortical pyramidal neurons were observed in children/adolescents...
March 1, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28333901/influence-of-the-recurrent-syncope-episodes-on-neurocognitive-functions-in-patients-with-vasovagal-syncope
#9
Joanna Jędrzejczyk-Spaho, Artur Z Pietrucha, Agnieszka Borowiec, Irena Bzukała, Mateusz Wnuk, Ewa Konduracka, Jadwiga Nessler
The aim of study was to evaluate an influence of recurrent syncope episodes on the neurocognitive functions (NCF) in patients with suspected VVS. AIM: The aim of study was to evaluate an influence of recurrent syncope episodes on the neurocognitive functions (NCF) in patients with suspected VVS. MATERIALS AND METHODS: Study population: 24 pts. (16 women) aged 17-70 yrs (mean age 40 years), with suspected VVS, referred to HUTT (head-up tilt test). All pts. underwent initial evaluation regarding to the number and circumstances of the syncopal and/or presyncopal spells...
March 21, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28333530/hard-earned-wisdom-exploratory-processing-of-difficult-life-experience-is-positively-associated-with-wisdom
#10
Nic M Weststrate, Judith Glück
Laypersons and experts believe that wisdom is cultivated through a diverse range of positive and negative life experiences. Yet, not all individuals with life experience are wise. We propose that one possible determinant of growth in wisdom from life experience is self-reflection. In a life span sample of adults (N = 94) ranging from 26 to 92 years of age, we examined wisdom's relationship to self-reflection by investigating "why" people report reflecting on the past (i.e., reminiscence functions) and "how" they reflect within autobiographical memories of difficult life events (i...
April 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28333505/competing-cues-older-adults-rely-on-knowledge-in-the-face-of-fluency
#11
Nadia M Brashier, Sharda Umanath, Roberto Cabeza, Elizabeth J Marsh
Consumers regularly encounter repeated false claims in political and marketing campaigns, but very little empirical work addresses their impact among older adults. Repeated statements feel easier to process, and thus more truthful, than new ones (i.e., illusory truth). When judging truth, older adults' accumulated general knowledge may offset this perception of fluency. In two experiments, participants read statements that contradicted information stored in memory; a post-experimental knowledge check confirmed what individual participants knew...
March 23, 2017: Psychology and Aging
https://www.readbyqxmd.com/read/28333504/healthy-aging-and-visual-working-memory-the-effect-of-mixing-feature-and-conjunction-changes
#12
Stephen Rhodes, Mario A Parra, Nelson Cowan, Robert H Logie
It has been suggested that an age-related decrease in the ability to bind and retain conjunctions of features may account for some of the pronounced decline of visual working memory (VWM) across the adult life span. So far the evidence for this proposal has been mixed with some suggesting a specific deficit in binding to location, while the retention of surface feature conjunctions (e.g., color-shape) appears to remain largely intact. The present experiments follow up on the results of an earlier study, which found that older adults were specifically poor at detecting conjunction changes when they were mixed with trials containing changes to individual features, relative to when these trials were blocked (Cowan, Naveh-Benjamin, Kilb, & Saults, 2006)...
March 23, 2017: Psychology and Aging
https://www.readbyqxmd.com/read/28333502/temporal-dynamics-of-cognitive-performance-and-anxiety-across-older-adulthood
#13
Andrew J Petkus, Chandra A Reynolds, Julie Loebach Wetherell, William S Kremen, Margaret Gatz
Cognitive decline and anxiety symptoms commonly co-occur in later life, but the temporal order of changes on these two attributes is unclear. Specifically, it is unknown if greater anxiety leads to subsequent declines in cognitive performance or if worse cognitive performance leads to increased anxiety. In this study, we sought to elucidate the temporal dynamics between anxiety symptoms and cognitive performance across old age-that is, the extent to which level and change in one variable influence subsequent changes in a second variable...
March 23, 2017: Psychology and Aging
https://www.readbyqxmd.com/read/28333492/perceptual-and-memory-inhibition-deficits-in-clinically-healthy-older-adults-are-associated-with-region-specific-doubly-dissociable-patterns-of-cortical-thinning
#14
Teal S Eich, Qolamreza R Razlighi, Yaakov Stern
Converging evidence suggests that the cognitive control processes that enable the inhibition of irrelevant information on a perceptual versus a memorial basis are qualitatively different and are underlain by unique neural systems that may be affected differentially in aging. In the current study, we investigated whether individual differences in performance on these 2 types of inhibitory processes were attributable to region-specific patterns of cortical thinning. Clinically healthy older adults completed a pair of behavioral memory and perceptual inhibition tasks and then underwent structural brain imaging...
March 23, 2017: Behavioral Neuroscience
https://www.readbyqxmd.com/read/28333472/how-stable-is-the-personal-past-stability-of-most-important-autobiographical-memories-and-life-narratives-across-eight-years-in-a-life-span-sample
#15
Christin Köber, Tilmann Habermas
Considering life stories as the most individual layer of personality (McAdams, 2013) implies that life stories, similar to personality traits, exhibit some stability throughout life. Although stability of personality traits has been extensively investigated, only little is known about the stability of life stories. We therefore tested the influence of age, of the proportion of normative age-graded life events, and of global text coherence on the stability of the most important memories and of brief entire life narratives as 2 representations of the life story...
March 23, 2017: Journal of Personality and Social Psychology
https://www.readbyqxmd.com/read/28333243/polycystic-ovary-syndrome-is-associated-with-anogenital-distance-a-marker-of-prenatal-androgen-exposure
#16
Yingchen Wu, Guangzheng Zhong, Shengfu Chen, Chengyu Zheng, Dehua Liao, Meiqing Xie
STUDY QUESTION: Is the presence of polycystic ovary syndrome (PCOS) associated with anogenital distance (AGD), a biomarker for the prenatal hormonal environment? SUMMARY ANSWER: The presence of PCOS is associated with longer AGD. WHAT IS KNOWN ALREADY: Although the aetiology of PCOS is unclear, emerging data suggest that the natural history of PCOS may originate from intrauterine life. Prenatal exposure to androgen hormones is considered an important factor of PCOS...
March 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28332732/spanish-version-of-the-mattis-dementia-rating-scale-2-for-early-detection-of-alzheimer-s-disease-and-mild-cognitive-impairment
#17
Elina Boycheva, Israel Contador, Bernardino Fernández-Calvo, Francisco Ramos-Campos, Verónica Puertas-Martín, Alberto Villarejo-Galende, Félix Bermejo-Pareja
OBJECTIVE: We aimed to analyse the clinical utility of the Mattis Dementia Rating Scale (MDRS-2) for early detection of Alzheimer's disease (AD) and amnestic mild cognitive impairment (MCI) in a sample of Spanish older adults. METHODS: A total of 125 participants (age = 75.12 ± 6.83, years of education =7.08 ± 3.57) were classified in three diagnostic groups: 45 patients with mild AD, 37 with amnestic MCI-single and multiple domain and 43 cognitively healthy controls (HCs)...
March 23, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28332040/edinburgh-cognitive-and-behavioural-als-screen-ecas-italian-version-regression-based-norms-and-equivalent-scores
#18
Mattia Siciliano, Luigi Trojano, Francesca Trojsi, Roberta Greco, Manuela Santoro, Giuseppe Basile, Fausta Piscopo, Alfonsina D'Iorio, Manila Patrone, Cinzia Femiano, Mariarosaria Monsurrò, Gioacchino Tedeschi, Gabriella Santangelo
Cognitive assessment for individuals with Amyotrophic Lateral Sclerosis (ALS) can be difficult because of frequent occurrence of difficulties with speech, writing, and drawing. The Edinburgh Cognitive and Behavioural ALS Screen (ECAS) is a recent multi-domain neuropsychological screening tool specifically devised for this purpose, and it assesses the following domains: executive functions, social cognition, verbal fluency and language (ALS-specific), but also memory and visuospatial abilities (Non-ALS specific)...
March 22, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28329896/characterizing-literacy-and-cognitive-function-during-pregnancy-and-postpartum
#19
Lynn M Yee, Leslie A Kamel, Zara Quader, Priya V Rajan, Shaneah M Taylor, Rachel O'Conor, Michael S Wolf, Melissa A Simon
Objective The objective of this study was to characterize health literacy and cognitive function in a diverse cohort of pregnant women. Methods Pregnant and postpartum women underwent in-depth assessments of health literacy/numeracy and the cognitive domains of verbal ability, working memory, long-term memory, processing speed, and inductive reasoning. Differences by demographic characteristics and gestational age were assessed using chi-square tests and multivariable logistic regression. Results In this cohort of pregnant (N = 77) or postpartum (N = 24) women, 41...
March 22, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28329868/the-roles-for-prior-visual-experience-and-age-on-the-extraction-of-egocentric-distance
#20
Courtney P Wallin, Daniel A Gajewski, Rebeca W Teplitz, Sandra Mihelic Jaidzeka, John W Philbeck
Objectives: In a well-lit room, observers can generate well-constrained estimates of the distance to an object on the floor even with just a fleeting glimpse. Performance under these conditions is typically characterized by some underestimation but improves when observers have previewed the room. Such evidence suggests that information extracted from longer durations may be stored to contribute to the perception of distance at limited time frames. Here, we examined the possibility that this stored information is used differentially across age...
July 29, 2016: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
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