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https://www.readbyqxmd.com/read/29792873/effect-of-alzheimer-s-disease-risk-and-protective-factors-on-cognitive-trajectories-in-subjective-memory-complainers
#1
Stefan J Teipel, Enrica Cavedo, Simone Lista, Marie-Odile Habert, Marie-Claude Potier, Michel J Grothe, Stephane Epelbaum, Luisa Sambati, Geoffroy Gagliardi, Nicola Toschi, Michael Greicius, Bruno Dubois, Harald Hampel
INTRODUCTION: Cognitive change in people at risk of Alzheimer's disease (AD) such as subjective memory complainers is highly variable across individuals. METHODS: We used latent class growth modeling to identify distinct classes of nonlinear trajectories of cognitive change over 2 years follow-up from 265 subjective memory complainers individuals (age 70 years and older) of the INSIGHT-preAD cohort. We determined the effect of cortical amyloid load, hippocampus and basal forebrain volumes, and education on the cognitive trajectory classes...
May 21, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29792505/a-new-test-for-the-assessment-of-working-memory-in-clinical-settings-validation-and-norming-of-a-month-ordering-task
#2
Imke Buekenhout, José Leitão, Ana A Gomes
Month ordering tasks have been used in experimental settings to obtain measures of working memory (WM) capacity in older/clinical groups based solely on their face validity. We sought to assess the appropriateness of using a month ordering task in other contexts, including clinical settings, as a psychometrically sound WM assessment. To this end, we constructed a month ordering task (ucMOT), studied its reliability (internal consistency and temporal stability), and gathered construct-related and criterion-related validity evidence for its use as a WM assessment...
May 24, 2018: Psychological Assessment
https://www.readbyqxmd.com/read/29792493/does-increased-effort-compensate-for-performance-debilitating-test-anxiety
#3
David W Putwain, Wendy Symes
It is well established that test anxiety is negatively related to examination performance. Based on attentional control theory, the aim of this study was to examine whether increased effort can protect against performance debilitating test anxiety. Four hundred and sixty-six participants (male = 228; 48.9%; White = 346, 74.3%; mean age = 15.7 years) completed self-report measures of test anxiety and effort that were matched to performance on a high-stakes secondary school examination. The worry and bodily symptoms components of test anxiety were negatively, and effort, positively related to examination performance...
May 24, 2018: School Psychology Quarterly
https://www.readbyqxmd.com/read/29792473/cognitive-and-affective-associations-with-an-ecologically-valid-test-of-theory-of-mind-across-the-lifespan
#4
Emilie Johansson Nolaker, Kim Murray, Francesca Happé, Rebecca A Charlton
OBJECTIVES: Many studies have demonstrated that theory of mind (ToM) ability declines with increasing age. Research has found that ToM-age associations are often mediated by other cognitive abilities particularly executive function. However, older adults rarely complain about real-world ToM difficulties. It has been suggested that older adults may perform better in real-world situations compared with experimental settings. METHOD: We examined performance on the Strange Stories Film Task (SSFT) which has been designed to assess ToM using naturalistic, video scenarios...
May 24, 2018: Neuropsychology
https://www.readbyqxmd.com/read/29792238/mapping-the-neuroanatomic-substrates-of-cognition-in-familial-attention-deficit-hyperactivity-disorder
#5
Rachel Muster, Saadia Choudhury, Wendy Sharp, Steven Kasparek, Gustavo Sudre, Philip Shaw
BACKGROUND: While the neuroanatomic substrates of symptoms of attention deficit hyperactivity disorder (ADHD) have been investigated, less is known about the neuroanatomic correlates of cognitive abilities pertinent to the disorder, particularly in adults. Here we define the neuroanatomic correlates of key cognitive abilities and determine if there are associations with histories of psychostimulant medication. METHODS: We acquired neuroanatomic magnetic resonance imaging data from 264 members of 60 families (mean age 29...
May 24, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29791867/longitudinal-assessment-of-chemotherapy-induced-changes-in-brain-and-cognitive-functioning-a-systematic-review
#6
REVIEW
Mingmei Li, Karen Caeyenberghs
In addition to the burden of a life-threatening diagnosis, cancer patients are struggling with adverse side-effects from cancer treatment. Chemotherapy has been linked to an array of cognitive impairments and alterations in brain structure and function ("chemobrain"). In this review, we summarized the existing evidence that evaluate the changes in cognitive functioning and brain with chemotherapy, as assessed using structural and functional MRI-based techniques in a longitudinal design. This review followed the latest PRISMA guidelines using Embase, Medline, PsychINFO, Scopus, and Web of Science databases with date restrictions from 2012-2017...
May 20, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29791637/board-games-gerotechnology-in-nursing-care-practice
#7
Paula Cristina de Andrade Pires Olympio, Neide Aparecida Titonelli Alvim
OBJECTIVE: To create a board game as a form of gerotechnology to promote active and healthy aging. METHOD: This was a qualitative, convergent care study conducted with 32 older adults. Individual interviews, creativity and sensitivity techniques, group discussions, and participant observations guided by Paulo Freire's theoretical framework of problematization were used to produce data. The participants and researchers assessed the entire production process at the end of the study, after the gerotechnology was implemented in the groups...
2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29790790/the-effects-of-amantadine-on-traumatic-brain-injury-outcome-a-double-blind-randomized-controlled-clinical-trial
#8
Hossein Ghalaenovi, Arash Fattahi, Jalil Koohpayehzadeh, Mahmoud Khodadost, Neda Fatahi, Morteza Taheri, Alireza Azimi, Sadra Rohani, Hessam Rahatlou
INTRODUCTION: Amantadine, as a dopamine receptor agonist, may stimulate and help the recovery of the nervous system after traumatic brain injury (TBI). METHODS: We performed this study as a double-blind, randomized, controlled clinical trial with target population including all patients with TBI who scored nine or lower on the Glasgow Coma Scale (GCS), admitted to our hospital between January 2013 and April 2014. The protocol included administration of the drug (placebo or amantadine) for 6 weeks and patient evaluation using the GCS and FOUR score on the first, third and seventh days after the drug was started...
May 23, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29790568/-social-cognition-and-cognitive-functions-in-patients-with-epilepsy-treated-with-eslicarbazepine-acetate
#9
L Abraira, A Sanabria, G Ortega, M Quintana, E Santamarina, J Salas-Puig, M Toledo
INTRODUCTION: Epilepsy is accompanied by cognitive disorders, frequently aggravated by the use of antiepileptic drugs, which can affect social empathy. AIM: To analyse the impact of treatment with eslicarbazepine acetate (ESL) on social cognition and prefrontal cognitive functions in adults with focal epilepsy. PATIENTS AND METHODS: We conducted a prospective single-centre study with patients aged between 18 and 65 years with focal seizures treated with ESL...
June 1, 2018: Revista de Neurologia
https://www.readbyqxmd.com/read/29789880/distinctive-cd8-t-cell-and-mhc-class-i-signatures-in-polycythemia-vera-patients
#10
Elsa M Cardoso, André J Esgalhado, Luís Patrão, Mónica Santos, Vasco Pinto Neves, Jorge Martinez, Maria Assunção Vaz Patto, Helena Silva, Fernando A Arosa
Polycythemia vera (PV) is a myeloproliferative neoplasm characterized by overproduction of red blood cells. We have performed a comprehensive characterization of blood immune cells for expression of naïve and memory receptors as well as β2 m-associated and β2 m-free MHC class I heavy chains, also known as closed and open conformers, respectively, in PV patients and age-matched controls (CTR). We show that the peripheral CD3+ CD8+ T cell pool in PV patients is clearly divided into two discrete populations, a more granular CD3+ CD8high T cell population enriched in effector-memory CD45RA+ T cells (CD8+ TEMRA) when compared to CTR (P < 0...
May 22, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29788900/association-between-vascular-comorbidity-and-progression-of-alzheimer-s-disease-a-two-year-observational-study-in-norwegian-memory-clinics
#11
Rannveig Sakshaug Eldholm, Karin Persson, Maria Lage Barca, Anne-Brita Knapskog, Lena Cavallin, Knut Engedal, Geir Selbaek, Eva Skovlund, Ingvild Saltvedt
BACKGROUND: Vascular risk factors increase the risk of Alzheimer's disease (AD), but there is limited evidence on whether comorbid vascular conditions and risk factors have an impact on disease progression. The aim of this study was to examine the association between vascular disease and vascular risk factors and progression of AD. METHODS: In a longitudinal observational study in three Norwegian memory clinics, 282 AD patients (mean age 73.3 years, 54% female) were followed for mean 24 (16-37) months...
May 22, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29788464/confucian-values-as-a-buffer-against-age-based-stereotype-threat-for-chinese-older-adults
#12
Shyuan Ching Tan, Sarah J Barber
Objectives: Research has shown that stereotype threat can impair older adults' memory in Western cultures. We tested whether this also occurs for older adults from the East Asian Chinese culture. We also tested whether an intervention that highlighted Confucian principles would protect Chinese older adults from stereotype threat's detrimental effects. Method : Culturally-Chinese older adults residing in the United States completed a memory test either under age-based stereotype threat about cognitive decline or not...
May 16, 2018: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/29788390/cognitive-performance-as-predictor-and-outcome-of-adolescent-bariatric-surgery-a-nonrandomized-pilot-study
#13
Eleanor R Mackey, Marni Jacobs, Evan P Nadler, Alexandra Olson, Alaina Pearce, J Bradley C Cherry, Sheela N Magge, Michele Mietus-Snyer, Chandan Vaidya
Objectives: Evidence in adults suggests that improvements in cognitive performance may follow weight loss resulting from bariatric surgery, and baseline cognitive performance may be associated with weight loss following surgery. This has not been evaluated in adolescents. Method: Participants were 38 adolescents of age 14-21 years composed of three groups: (1) 12 adolescents with severe obesity who received vertical sleeve gastrectomy during the study (VSG); (2) 14 adolescents with severe obesity who were wait-listed for VSG (WL); and (3) 12 healthy weight controls (HC)...
May 16, 2018: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29788381/the-role-of-apathy-and-depression-on-verbal-learning-and-memory-performance-after-stroke
#14
Keera N Fishman, Andrea R Ashbaugh, Krista L Lanctôt, Megan L Cayley, Nathan Herrmann, Brian J Murray, Michelle Sicard, Karen Lien, Demetrios J Sahlas, Richard H Swartz
Objective: Psychiatric symptoms, including depression and apathy, may significantly impede functional and cognitive capabilities following a cerebrovascular event. This study examined the role of apathy and depression on learning and memory performance in stroke patients. Method: Stroke patients (n = 140 [119 ischemic, 21 hemorrhagic], mean age = 60.6 [SD = 15.1]) completed the Apathy Evaluation Scale (AES), the Center for Epidemiologic Studies Depression Scale (CES-D), and the California Verbal Learning Test-Second Edition (CVLT-II)...
May 18, 2018: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29788121/targeted-metabolomics-shows-low-plasma-lysophosphatidylcholine-18-2-predicts-greater-decline-of-gait-speed-in-older-adults-the-baltimore-longitudinal-study-of-aging
#15
Marta Gonzalez-Freire, Ruin Moaddel, Kai Sun, Elisa Fabbri, Pingbo Zhang, Mohammed Khadeer, Norman Salem, Luigi Ferrucci, Richard D Semba
Background: Gait speed is an important measure of lower extremity physical performance in older adults and is predictive of disability and mortality. The biological pathways involved in the decline of lower extremity physical performance are not well understood. We used a targeted metabolomics approach to identify plasma metabolites predictive of change in gait speed over time. Methods: Gait speed was measured at baseline and over median follow-up of 50.5 months in 504 adults, aged ≥50 years, who had two or more study visits in the Baltimore Longitudinal Study of Aging (BLSA)...
May 17, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29787954/the-effectiveness-of-a-cognitive-training-program-in-people-with-mild-cognitive-impairment-a-study-in-urban-community
#16
Chalermpong Sukontapol, Sasithorn Kemsen, Sirintorn Chansirikarn, Daochompu Nakawiro, Orawan Kuha, Unchulee Taemeeyapradit
OBJECTIVE: To assess the effectiveness of a cognitive training program on global cognition among people with mild cognitive impairment. METHODS: In this experimental study, using purposive sampling, 60 participants age 50 years and over who complained of subjective memory impairment were screened in their communities by public health volunteers with the Abbreviated Mental Test. Those with dementia were excluded as well as those with depression, which were screened out by the Thai Geriatric Depression Scale (TGDS-15)...
May 19, 2018: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29787937/can-working-memory-training-improve-children-s-sleep
#17
Jon Quach, Megan Spencer-Smith, Peter J Anderson, Gehan Roberts
BACKGROUND: Improving children's sleep could lead to significant benefits in several functional domains. Recent research in adults suggests that intensive, adaptive cognitive training may be beneficial in improving sleep, although there is limited understanding whether this approach yields similar results in children. OBJECTIVE: To determine whether a working memory training program improved sleep latency, sleep problems, and sleep duration on school and nonschool nights and whether there was a differential effect of the timing of training during the school day on sleep outcomes...
December 20, 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29787900/associations-between-prenatal-and-childhood-pbde-exposure-and-early-adolescent-visual-verbal-and-working-memory
#18
Whitney J Cowell, Amy Margolis, Virginia A Rauh, Andreas Sjödin, Richard Jones, Ya Wang, Wanda Garcia, Frederica Perera, Shuang Wang, Julie B Herbstman
BACKGROUND: Prenatal and childhood exposure to polybrominated diphenyl ether (PBDE) flame retardants has been inversely associated with cognitive performance, however, few studies have measured PBDE concentrations in samples collected during both prenatal and postnatal periods. METHODS: We examined prenatal (cord) and childhood (ages 2, 3, 5, 7 and 9 years) plasma PBDE concentrations in relation to memory outcomes assessed between the ages of 9 and 14 years...
May 19, 2018: Environment International
https://www.readbyqxmd.com/read/29787792/age-dependent-alterations-in-expression-and-co-localization-of-pax6-and-ras-gap-in-brain-of-aging-mice
#19
Khushboo Srivastava, Ratnakar Tripathi, Rajnikant Mishra
As the brain ages, the survival and plasticity of neurons and glia are compromised. The data-mining and in silico studies suggest interactions of Pax6 with Ras and binding sites in Ras-GAP promoter. The Pax6 also shows age-dependent alterations. Therefore, it is presumed that Pax6 may be associated with the Ras-GAP, a synaptic protein, either directly or indirectly in brain. The expression, co-localization and interaction of Pax6 and Ras-GAP in different regions of brain of mice during aging were investigated through immunofluorescence assay, co-immunoprecipitation and western blotting, respectively...
May 19, 2018: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29787609/an-investigation-of-cerebral-oxygen-utilization-blood-flow-and-cognition-in-healthy-aging
#20
Sarah J Catchlove, Helen Macpherson, Matthew E Hughes, Yufen Chen, Todd B Parrish, Andrew Pipingas
BACKGROUND: Understanding how vascular and metabolic factors impact on cognitive function is essential to develop efficient therapies to prevent and treat cognitive losses in older age. Cerebral metabolic rate of oxygen (CMRO2), cerebral blood flow (CBF) and venous oxygenation (Yv) comprise key physiologic processes that maintain optimum functioning of neural activity. Changes to these parameters across the lifespan may precede neurodegeneration and contribute to age-related cognitive decline...
2018: PloS One
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