keyword
https://read.qxmd.com/read/37494277/short-range-interactions-between-fibrocytes-and-cd8-t-cells-in-copd-bronchial-inflammatory-response
#21
JOURNAL ARTICLE
Edmée Eyraud, Elise Maurat, Jean-Marc Sac-Epée, Pauline Henrot, Maeva Zysman, Pauline Esteves, Thomas Trian, Jean-William Dupuy, Alexander Leipold, Antoine-Emmanuel Saliba, Hugues Begueret, Pierre-Olivier Girodet, Matthieu Thumerel, Romain Hustache-Castaing, Roger Marthan, Florian Levet, Pierre Vallois, Cécile Contin-Bordes, Patrick Berger, Isabelle Dupin
Bronchi of chronic obstructive pulmonary disease (COPD) are the site of extensive cell infiltration, allowing persistent contact between resident cells and immune cells. Tissue fibrocytes interaction with CD8+ T cells and its consequences were investigated using a combination of in situ , in vitro experiments and mathematical modeling. We show that fibrocytes and CD8+ T cells are found in the vicinity of distal airways and that potential interactions are more frequent in tissues from COPD patients compared to those of control subjects...
July 26, 2023: ELife
https://read.qxmd.com/read/37479821/development-of-cochlear-spiral-ligament-fibrocytes-of-the-common-marmoset-a-nonhuman-model-animal
#22
JOURNAL ARTICLE
Makoto Hosoya, Kaho Iwabu, Tsubasa Kitama, Takanori Nishiyama, Naoki Oishi, Hideyuki Okano, Hiroyuki Ozawa
Spiral ligament fibrocytes generate potassium gradients, which hair cells require to convert mechanical sound waves into electrical palsy. Together with the stria vascularis, they regulate endolymph electrolyte homeostasis. Developing spiral ligament fibrocytes and generating endocochlear potential with an appropriate endolymph ion composition are essential for hearing. Understanding spiral ligament fibrocyte development is useful for studying age-related and genetic hearing loss, as well as for regenerative therapy and cochlear immunology...
July 21, 2023: Scientific Reports
https://read.qxmd.com/read/37448696/cochlear-implantation-impairs-intracochlear-microcirculation-and-counteracts-inos-induction-in-guinea-pigs
#23
JOURNAL ARTICLE
Benjamin Philipp Ernst, Ulf-Rüdiger Heinrich, Mathias Fries, Regina Meuser, Tobias Rader, Jonas Eckrich, Roland H Stauber, Sebastian Strieth
INTRODUCTION: Preservation of residual hearing remains a great challenge during cochlear implantation. Cochlear implant (CI) electrode array insertion induces changes in the microvasculature as well as nitric oxide (NO)-dependent vessel dysfunction which have been identified as possible mediators of residual hearing loss after cochlear implantation. METHODS: A total of 24 guinea pigs were randomized to receive either a CI ( n = 12) or a sham procedure (sham) by performing a cochleostomy without electrode array insertion ( n = 12)...
2023: Frontiers in Cellular Neuroscience
https://read.qxmd.com/read/37398468/alterations-in-the-mammary-gland-and-tumor-microenvironment-of-formerly-obese-mice
#24
Genevra Kuziel, Brittney N Moore, Grace P Haugstad, Yue Xiong, Abbey E Williams, Lisa M Arendt
Obesity is a risk factor for breast cancer, and women with obesity that develop breast cancer have a worsened prognosis. Within the mammary gland, obesity causes chronic, macrophage-driven inflammation and adipose tissue fibrosis. To examine the impact of weight loss on the mammary microenvironment, mice were fed high-fat diet to induce obesity, then switched to a low-fat diet. In formerly obese mice, we observed reduced numbers of crown-like structures and fibrocytes in mammary glands, while collagen deposition was not resolved with weight loss...
June 14, 2023: bioRxiv
https://read.qxmd.com/read/37394152/fibroblast-growth-factor-soaked-collagen-membrane-shows-no-biomechanical-or-histological-advantages-in-the-treatment-of-chronic-rotator-cuff-tears-in-a-rabbit-model
#25
JOURNAL ARTICLE
Jotyar Ali, Anil Pulatkan, Deniz Kara, Okan Tezgel, Abdulhamit Misir, Vahdet Ucan, Ergun Bozdag, Ayse Nur Yildirim, Fatih Yildiz, Ibrahim Tuncay, Mehmet Kapicioglu, Kerem Bilsel
PURPOSE: The aim of this study was to investigate the histological and biomechanical effects of a fibroblast growth factor (FGF-2)-soaked collagen membrane used to treat a full-thickness chronic rotator cuff (RC) rupture in a rabbit model. METHODS: Forty-eight shoulders from 24 rabbits were used. At the beginning of the procedure, 8 rabbits were killed to assess the control group (Group IT) with intact tendons. To establish a chronic RC tear model, a full-thickness subscapularis tear was created on both shoulders of the remaining 16 rabbits and left for 3 months...
June 30, 2023: Arthroscopy
https://read.qxmd.com/read/37356133/pulmonary-fibrosis-and-type-17-immunity
#26
REVIEW
Satoru Senoo, Hisao Higo, Akihiko Taniguchi, Katsuyuki Kiura, Yoshinobu Maeda, Nobuaki Miyahara
Fibrosis of the lung can occur in idiopathic pulmonary fibrosis, collagen vascular diseases, and hypersensitivity pneumonitis, among other diseases. Transforming growth factor (TGF)-β, vascular epithelial growth factor, fibroblast growth factor, and platelet-derived growth factor contribute to the pathophysiology of fibrosis. TGF-β and other cytokines, including interleukin (IL)-1β, IL-6, and IL-23, activate type-17 immunity, which is involved in pulmonary fibrosis. The components of type-17 immunity include type-17 helper T cells, γδT cells, IL-17A-producing CD8-positive T cells, invariant NKT cells, and group 3 innate lymphoid cells...
June 23, 2023: Respiratory Investigation
https://read.qxmd.com/read/37342915/fibrocytes-enhance-mammary-gland-fibrosis-in-obesity
#27
JOURNAL ARTICLE
Genevra Kuziel, Brittney N Moore, Grace P Haugstad, Lisa M Arendt
Obesity rates continue to rise, and obese individuals are at higher risk for multiple types of cancer, including breast cancer. Obese mammary fat is a site of chronic, macrophage-driven inflammation, which enhances fibrosis within adipose tissue. Elevated fibrosis within the mammary gland may contribute to risk for obesity-associated breast cancer. To understand how inflammation due to obesity enhanced fibrosis within mammary tissue, we utilized a high-fat diet model of obesity and elimination of CCR2 signaling in mice to identify changes in immune cell populations and their impact on fibrosis...
July 2023: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/37329987/health-prevention-intervention-for-chronic-tissue-fibrosis-based-on-the-specific-expression-of-ccl19-21%C3%A2-%C3%A2-mast-cell
#28
JOURNAL ARTICLE
Xiangmei Zhang, Jidong Zhao, Beichen Liu, Shuguang Ren, Xiaohan Zhao, Xiaofei Ren, Xindi Ma, Yunjiang Liu
Chronic tissue fibrosis is a common pathological feature of connective tissue diseases and malignant tumors, and its prevention has been a major focus of relevant research.However, the details of the mechanism of action of tissue-colonizing immune cells in fibroblast migration are unclear. In this study, connective tissue disease tissue specimens and solid tumor specimens were selected to observe the relationship between mast cells and interstitial fibrosis and the expression characteristics of mast cells. Our findings suggest that the number of mast cells in the tissue correlates with the degree of pathological fibrosis and that mast cells specifically express the chemokines CCL19 and CCL21, especially CCL19...
June 15, 2023: Preventive Medicine
https://read.qxmd.com/read/37327638/serum-amyloid-p-attenuates-hypertrophic-scarring-in-large-animal-models
#29
JOURNAL ARTICLE
Alicia D Menchaca, Candace C Style, David A Lazar, Oren Mushin, Oluyinka O Olutoye
INTRODUCTION: This study's purpose was to (1)determine the effect of locally administered serum amyloid P (SAP) on the development of hypertrophic scars (HTS) in porcine and rabbit HTS models and (2)determine the pharmacokinetics of systemically administered SAP and its effect on circulating fibrocyte quantities. METHODS: Two large animal (New Zealand White Rabbit and Female Red Duroc Pigs) HTS models were utilized to study the effects of daily local injections of SAP immediately post wounding (x5 d in rabbits; x7 d in pigs) on HTS development as measured by scar elevation index , scar area, wound closure, and molecular expression studies of scar components...
June 14, 2023: Journal of Surgical Research
https://read.qxmd.com/read/37312173/non-typical-persistent-hyperplastic-primary-vitreous-a-rare-case-report-and-review-of-the-literature
#30
REVIEW
Yinhui Yu, Yue Qiao, Silong Chen, Jianghua Hu, Jinyu Li, Ke Yao, Yibo Yu
BACKGROUND: Persistent hyperplastic primary vitreous (PHPV), also known as persistent fetal vasculature (PFV), is a clinical entity that traditionally presents with leukocoria, microphthalmia, retinal dysplasia, or eyeball shrinkage which is associated with poor vision. However, there is a dearth of literature on cases of PHPV in adulthood or with asymptomatic occurrence. This report presents the clinical and pathological findings of a non-typical PHPV case and discuss the current knowledge for this condition...
June 13, 2023: BMC Ophthalmology
https://read.qxmd.com/read/37296179/induced-pluripotent-and-cd34-%C3%A2-stem-cell-derived-myeloid-cells-display-differential-responses-to-particle-and-dust-mite-exposure
#31
JOURNAL ARTICLE
Leonie F H Fransen, Martin O Leonard
Myeloid cells form an essential component of initial responses to environmental hazards and toxic exposures. The ability to model these responses in vitro is central to efforts tasked with identifying hazardous materials and understanding mechanisms of injury and disease. Induced pluripotent stem cell (iPSC) derived cells have been suggested as alternatives to more established primary cell testing systems for these purposes. iPSC derived macrophage and dendritic like cells were compared to CD34+ haematopoietic stem cell derived populations using transcriptomic analysis...
June 9, 2023: Scientific Reports
https://read.qxmd.com/read/37258461/mitochondrial-alterations-in-the-cochlea-of-cdk5rap1-knockout-mice-with-age-related-hearing-loss
#32
JOURNAL ARTICLE
Toru Miwa, Tatsuya Katsuno, Fan-Yan Wei, Kazuhito Tomizawa
Previous studies have revealed that age-related hearing loss (AHL) in Cdk5 regulatory subunit associated protein 1 (Cdk5rap1)-knockout mice is associated with pathology in the cochlea. Here, we aimed to identify mitochondrial alterations in the cochlea of Cdk5rap1-knockout mice with AHL. Mitochondria in the spiral ganglion neurons (SGNs) and hair cells (HCs) were normal despite senescence; however, the mitochondria of types I, II, and IV spiral ligament fibrocytes were ballooned, damaged, and ballooned, respectively, in the stria vascularis...
May 31, 2023: FEBS Open Bio
https://read.qxmd.com/read/37241170/cd34-structure-functions-and-relationship-with-cancer-stem-cells
#33
REVIEW
Petru Radu, Mihai Zurzu, Vlad Paic, Mircea Bratucu, Dragos Garofil, Anca Tigora, Valentin Georgescu, Virgiliu Prunoiu, Costin Pasnicu, Florian Popa, Petra Surlin, Valeriu Surlin, Victor Strambu
The CD34 protein was identified almost four decades ago as a biomarker for hematopoietic stem cell progenitors. CD34 expression of these stem cells has been exploited for therapeutic purposes in various hematological disorders. In the last few decades, studies have revealed the presence of CD34 expression on other types of cells with non-hematopoietic origins, such as interstitial cells, endothelial cells, fibrocytes, and muscle satellite cells. Furthermore, CD34 expression may also be found on a variety of cancer stem cells...
May 12, 2023: Medicina
https://read.qxmd.com/read/37229131/integrating-biochemical-and-anatomical-characterizations-with-transcriptome-analysis-to-dissect-superior-stem-strength-of-zs11-brassica-napus
#34
JOURNAL ARTICLE
Zhengshu Tian, Xinfa Wang, Xiaoling Dun, Ze Tian, Xiaoxue Zhang, Jinfeng Li, Lijun Ren, Jinxing Tu, Hanzhong Wang
Stem lodging resistance is a serious problem impairing crop yield and quality. ZS11 is an adaptable and stable yielding rapeseed variety with excellent resistance to lodging. However, the mechanism regulating lodging resistance in ZS11 remains unclear. Here, we observed that high stem mechanical strength is the main factor determining the superior lodging resistance of ZS11 through a comparative biology study. Compared with 4D122, ZS11 has higher rind penetrometer resistance (RPR) and stem breaking strength (SBS) at flowering and silique stages...
2023: Frontiers in Plant Science
https://read.qxmd.com/read/37184499/cell-biology-of-spontaneous-persistent-epithelial-defects-after-photorefractive-keratectomy-in-rabbits
#35
JOURNAL ARTICLE
Lycia Pedral Sampaio, Valeria Villabona Martinez, Thomas Michael Shiju, Guilherme S L Hilgert, Marcony R Santhiago, Steven E Wilson
PURPOSE: To evaluate wound healing in rabbit corneas that developed a spontaneous persistent epithelial defect (PED) after photorefractive keratectomy (PRK). METHODS: Forty-eight 10- to 15-week-old female New Zealand White rabbits weighing 2.5 to 3.0 kg underwent either -3 diopter (D) or -9 D PRK to generate a series of corneas to study wound healing after injury. During that series, seven corneas developed a PED detected with 1% fluorescein staining at a slit lamp that either did not have epithelial closure by 1 week after surgery or subsequently had the closed epithelium break down to form a PED 2 to 3 weeks after surgery...
May 1, 2023: Translational Vision Science & Technology
https://read.qxmd.com/read/37093074/circulating-fibrocyte-percentage-and-neutrophil-lymphocyte-ratio-are-accurate-biomarkers-of-uncomplicated-and-complicated-appendicitis-a-prospective-cohort-study
#36
JOURNAL ARTICLE
Mohamed Zarog, Peter O'Leary, Miranda Kiernan, Jarlath Bolger, Paul Tibbitts, Stephen Coffey, Gerard Byrnes, Colin Peirce, Colum Dunne, Calvin Coffey
BACKGROUND: There is increasing evidence that uncomplicated appendicitis (UA) may be treated nonoperatively in cases of UA. This study aimed to evaluate and compare the diagnostic accuracy of circulating fibrocyte percentage (CFP), white blood cell count, C-reactive protein, and neutrophil-lymphocyte ratio (NLR) in diagnosing uncomplicated and complicated appendicitis. MATERIALS AND METHODS: Eighty consecutive adult patients presenting with suspected appendicitis were recruited in a cohort-based prospective study between June 2015 and February 2016 at University Hospital Limerick in Ireland...
March 1, 2023: International Journal of Surgery
https://read.qxmd.com/read/37083059/effect-and-mechanism-of-imbalance-via-th9-cells-and-th17-treg-cells-in-inflammatory-and-fibrotic-phases-of-pulmonary-fibrosis-in-mice
#37
JOURNAL ARTICLE
Xiaoya Qu, Xue Yi, Hongyuan Zhong, Wenwen Ruan, Dongmei Huang
We investigate the role and mechanism of imbalance via Th9 cells and Th17/Treg cells in the inflammatory and fibrotic phases of pulmonary fibrosis in mice. A total of mice were split into normal saline (control group) and inflammation and fibrosis mouse models (study group) randomly, and lung tissues and bronchoalveolar lavage fluid (BALF) were obtained from mice at the inflammatory and fibrotic phases on the 7th and 28th day, respectively. The degenerative changes in the mouse lung tissue were then visible using H&E staining...
April 21, 2023: Biotechnology & Genetic Engineering Reviews
https://read.qxmd.com/read/37080573/autoantibodies-are-associated-with-disease-progression-in-idiopathic-pulmonary-fibrosis
#38
JOURNAL ARTICLE
Katerina Koether, Valérie Besnard, Hilary Sandig, Alan Carruthers, Elena Miranda, Sabine Grootenboer-Mignot, Camille Taillé, Sylvie Chevret, Dominique Valeyre, Hilario Nunes, Dominique Israel-Biet, Wei Keat Lim, Vincent Cottin, Dominic Corkill, Claire Dobson, Maria Groves, Franco Ferraro, Edouard Guenzi, Ling Huang, Michal Sulikowski, Arnaud Mailleux, Lynne Anne Murray, Thomas Mustelin, Ian Strickland, Matthew A Sleeman, Bruno Crestani
Several reports have highlighted a potential role of autoreactive B-cells and autoantibodies that correlates with increased disease severity in patients with idiopathic pulmonary fibrosis (IPF). Here we show that patients with IPF have an altered B-cell phenotype and that those subjects who have autoantibodies against the intermediate filament protein periplakin (PPL) have a significantly worse outcome in terms of progression-free survival. Using a mouse model of lung fibrosis, we demonstrate that introducing antibodies targeting the endogenous protein PPL (mimicking naturally occurring autoantibodies seen in patients) directly in the lung increases lung injury, inflammation, collagen and fibronectin expression through direct activation of follicular dendritic cells, which in turn activates and drives proliferation of fibroblasts...
May 2023: European Respiratory Journal
https://read.qxmd.com/read/37079186/dissecting-the-single-cell-transcriptome-network-of-macrophage-and-identifies-a-signature-to-predict-prognosis-in-lung-adenocarcinoma
#39
JOURNAL ARTICLE
Zhengyang Hu, Xing Jin, Weifeng Hong, Qihai Sui, Mengnan Zhao, Yiwei Huang, Ming Li, Qun Wang, Cheng Zhan, Zhencong Chen
PURPOSE: The tumor immune microenvironment (TME) plays a vital role in tumorigenesis, progression, and treatment. Macrophages, as an important component of the tumor microenvironment, play an essential role in antitumor immunity and TME remodeling. In this study, we aimed to explore the different functions of different origins macrophages in TME and their value as potential predictive markers of prognosis and treatment. METHODS: We performed single-cell analysis using 21 lung adenocarcinoma (LUAD), 12 normal, and four peripheral blood samples from our data and public databases...
April 20, 2023: Cellular Oncology (Dordrecht)
https://read.qxmd.com/read/37016665/interleukin-11-in-pathologies-of-the-nervous-system
#40
JOURNAL ARTICLE
M I Airapetov, S O Eresko, P D Ignatova, A A Lebedev, E R Bychkov, P D Shabanov
The study of the role of cytokines in various pathological conditions of the body is a topical area in modern biomedicine. Understanding the physiological roles played by cytokines will aid in finding applications for them as pharmacological agents in clinical practice. Interleukin 11 (IL-11) was discovered in 1990 in fibrocyte-like bone marrow stromal cells, but there has been increased interest in this cytokine in recent years. IL-11 has been shown to correct inflammatory pathways in the epithelial tissues of the respiratory system, where the main events occur during SARS-CoV-2 infection...
2023: Molecular Biology
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