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https://www.readbyqxmd.com/read/28337871/cytokine-modulation-in-patients-with-idiopathic-pulmonary-fibrosis-undergoing-treatment-with-steroids-immunosuppressants-and-ifn-%C3%AE-1b
#1
S Marinari, V De Iuliis, V Dadorante, S Colella, A Marino, A Nunziata, V Flati, M Caruso, A Pennelli, F De Benedetto, S Matera, S Capodifoglio, S Martinotti, S Caputi, E Toniato
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease of unknown etiology and pathogenic mechanisms. From an etiopathogenic point of view, alveolar macrophages play a key role in accumulation of fibroblasts and deposition of collagen and extracellular matrix by releasing specific cytokines and inflammatory mediators. IPF seems to be also associated with circulating fibrocytes, which might be involved with an abnormal pulmonary vascular repair and remodeling. Based on its hypothesized pathologic mechanisms, anti-inflammatory, anti-fibrotic and immunosuppressive therapies are often used...
January 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28289610/effect-of-basic-fibroblast-growth-factor-on-achilles-tendon-healing-in-rabbit
#2
Arash Najafbeygi, Mohammad Javad Fatemi, Amir Hussein Lebaschi, Seyed Jaber Mousavi, Seyed Abouzar Husseini, Mitra Niazi
BACKGROUND: Tendon injuries are common and it takes a long time for an injured tendon to heal. Adverse phenomena such as adhesion and rupture are associated with these injuries. Finding a method to reduce the time required for healing which improves the final outcome, will lead to decreased frequency and intensity of adverse consequences. This study was designed to investigate the effects of basic fibroblast growth factor on the healing of the Achilles tendon in rabbits. METHODS: In 10 New Zealand white rabbits, Achilles tendon was cut at the intersection of the distal and middle thirds on both hind legs...
January 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/28287322/protective-effect-of-pistacia-lentiscus-oil-against-bleomycin-induced-lung-fibrosis-and-oxidative-stress-in-rat
#3
Anouar Abidi, Nadhem Aissani, Hichem Sebai, Raja Serairi, Nadia Kourda, Saloua Ben Khamsa
We aimed in the present study to investigate the protective effect of Pistacia lentiscus oil against bleomycin-induced lung fibrosis as well as the involvement of oxidative stress in such protection. In this respect, adult male Wistar rats were used and divided into three groups of twenty each: control (NaCl, 0.9%), bleomycin, and bleomycin (4 mg/kg b.w.) + P. lentiscus oil (3 g/kg, b.w.). Animals were pretreated for 30 days before the induction of fibrosis by bleomycin and 1 wk after the induction of fibrosis...
April 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28280462/the-role-of-glia-in-the-peripheral-and-central-auditory-system-following-noise-overexposure-contribution-of-tnf-%C3%AE-and-il-1%C3%AE-to-the-pathogenesis-of-hearing-loss
#4
Verónica Fuentes-Santamaría, Juan Carlos Alvarado, Pedro Melgar-Rojas, María C Gabaldón-Ull, Josef M Miller, José M Juiz
Repeated noise exposure induces inflammation and cellular adaptations in the peripheral and central auditory system resulting in pathophysiology of hearing loss. In this study, we analyzed the mechanisms by which noise-induced inflammatory-related events in the cochlea activate glial-mediated cellular responses in the cochlear nucleus (CN), the first relay station of the auditory pathway. The auditory function, glial activation, modifications in gene expression and protein levels of inflammatory mediators and ultrastructural changes in glial-neuronal interactions were assessed in rats exposed to broadband noise (0...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28211211/circulating-fibrocyte-mobilization-in-negative-pressure-wound-therapy
#5
Dezhi Chen, Yong Zhao, Zonghuan Li, Kangquan Shou, Xun Zheng, Pengcheng Li, Baiwen Qi, Aixi Yu
Non-healing diabetic wounds are difficult to treat. They also create heavy financial burdens for both patients and society. Negative pressure wound therapy (NPWT) has been adopted to treat intractable wounds and has proved to be effective. However, the mechanisms that underlie the effects of this treatment are not entirely understood. Circulating fibrocytes are unique haematopoietic-derived stem cells that have been reported to play a pivotal role in wound healing. Here, we have investigated the effect of NPWT on fibrocyte mobilization and the role of fibrocyte mobilization in the healing of diabetic wounds during NPWT...
February 17, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28172772/p026-the-role-of-fibrocytes-in-mesenteric-crohn-s-disease
#6
M G Kiernan, S M Sahebally, P A Kiely, D Waldron, M Moloney, M Skelly, P N Faul, D P O'Leary, A J Lowery, L G Walsh, C P Dunne, J C Coffey
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28165063/heavy-chain-hyaluronan-pentraxin-3-from-amniotic-membrane-suppresses-inflammation-and-scarring-in-murine-lacrimal-gland-and-conjunctiva-of-chronic-graft-versus-host-disease
#7
Yoko Ogawa, Hua He, Shin Mukai, Toshihiro Imada, Shigeru Nakamura, Chen-Wei Su, Megha Mahabole, Scheffer C G Tseng, Kazuo Tsubota
Chronic graft-versus-host disease (cGVHD) is a major complication of hematopoietic stem cell transplantation. Dry eye disease is the prominent ocular sequel of cGVHD and is caused by excessive inflammation and fibrosis in the lacrimal glands. Heavy chain-Hyaluronan/Pentraxin 3 (HC-HA/PTX3) is a complex purified from human amniotic membrane (AM) and known to exert anti-inflammatory and anti-scarring actions. In this study, we utilized a mouse model of cGVHD to examine whether HC-HA/PTX3 could attenuate dry eye disease elicited by cGVHD...
February 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28135362/identification-of-circulating-fibrocytes-and-dendritic-derivatives-in-corneal-endothelium-of-patients-with-fuchs-dystrophy
#8
An-Katrien De Roo, Jasper Wouters, Olivier Govaere, Beatrijs Foets, Joost J van den Oord
Purpose: Fuchs' endothelial corneal dystrophy (FECD) is a degenerative eye disorder affecting 4% of Americans older than 40. It is the leading indication for corneal endothelial (CE) transplantation for which there is a global donor shortage. This study aimed to gain further insight into the pathophysiology of FECD and identify targets for nonsurgical therapy. Methods: CE from patients with late-onset FECD was compared with that of normal controls using microarray expression analysis (n = 4 FECD, n = 4 normal), reverse transcriptase quantitative PCR (n = 9 FECD, n = 8 normal), and immunohistology (n = 55 FECD, n = 15 normal)...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28122964/circulating-and-exosome-packaged-hepatitis-c-single-stranded-rna-induce-monocyte-differentiation-via-tlr7-8-to-polarized-macrophages-and-fibrocytes
#9
Banishree Saha, Karen Kodys, Adeyinka Adejumo, Gyongyi Szabo
Monocytes and macrophages (MΦs) play a central role in the pathogenesis of chronic hepatitis C virus (HCV) infection. The tissue microenvironment triggers monocyte differentiation into MΦs, with polarization ranging within the spectrum of M1 (classical) to M2 (alternative) activation. Recently, we demonstrated that HCV infection leads to monocyte differentiation into polarized MΦs that mediate stellate cell activation via TGF-β. In this study, we aimed to identify the viral factor(s) that mediate monocyte-to-MΦ differentiation...
March 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28112757/reversal-of-maladaptive-fibrosis-and-compromised-ventricular-function-in-the-pressure-overloaded-heart-by-a-caveolin-1-surrogate-peptide
#10
Dorea Pleasant-Jenkins, Charles Reese, Panneerselvem Chinnakkannu, Harinath Kasiganesan, Elena Tourkina, Stanley Hoffman, Dhandapani Kuppuswamy
Chronic ventricular pressure overload (PO) results in congestive heart failure (CHF) in which myocardial fibrosis develops in concert with ventricular dysfunction. Caveolin-1 is important in fibrosis in various tissues due to its decreased expression in fibroblasts and monocytes. The profibrotic effects of low caveolin-1 can be blocked with the caveolin-1 scaffolding domain peptide (CSD, a caveolin-1 surrogate) using both mouse models and human cells. We have studied the beneficial effects of CSD on mice in which PO was induced by trans-aortic constriction (TAC)...
January 23, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28111227/mesenchymal-cells-in-colon-cancer
#11
REVIEW
Vasiliki Koliaraki, Charles K Pallangyo, Florian R Greten, George Kollias
Mesenchymal cells in the intestine comprise a variety of cell types of diverse origins, functions, and molecular markers. They provide mechanical and structural support and have important functions during intestinal organogenesis, morphogenesis, and homeostasis. Recent studies of the human transcriptome have revealed their importance in the development of colorectal cancer, and studies from animal models have provided evidence for their roles in the pathogenesis of colitis-associated cancer and sporadic colorectal cancer...
January 20, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28089088/synovial-chondromatosis-of-the-temporomandibular-joint-immunohistochemical-examinations-regarding-the-role-of-insulin-like-growth-factors-and-their-binding-proteins-in-the-etiology-of-this-disease
#12
Christian T Wilms, Nils Heim, Marcus Teschke, Rudolf R Reich, Werner Götz
Synovial chondromatosis (SC) is a benign disease of the joints without a known cause. It sometimes affects the temporomandibular joint (TMJ) and is accompanied by pain, swelling, malocclusion, and crepitation. It has been divided into three stages by Milgram and is supposed to originate from the synovia and cartilage of a joint (Milgram, 1977b). The aim of this study was to examine an involvement of the insulin-like growth factors (IGF-I/-II) and their binding proteins (IGFBP-1 to -6) in the etiology of this disease...
December 14, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28028137/diversification-of-cell-lineages-in-ureter-development
#13
Tobias Bohnenpoll, Sarah Feraric, Marvin Nattkemper, Anna-Carina Weiss, Carsten Rudat, Max Meuser, Mark-Oliver Trowe, Andreas Kispert
The mammalian ureter consists of a mesenchymal wall composed of smooth muscle cells and surrounding fibrocytes of the tunica adventitia and the lamina propria and an inner epithelial lining composed of layers of basal, intermediate, and superficial cells. How these cell types arise from multipotent progenitors is poorly understood. Here, we performed marker analysis, cell proliferation assays, and genetic lineage tracing to define the lineage relations and restrictions of the mesenchymal and epithelial cell types in the developing and mature mouse ureter...
December 27, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28002516/experimental-animal-model-in-a-histological-study-of-drug-induced-gingival-overgrowth
#14
Adelina Gabriela Bobic, Ştefania CrăiŢoiu, Roxana Maria Pascu, Ileana Cristiana Croitoru, Marius Matei, Florian Obădan, Monica Mihaela CrăiŢoiu
Gingival overgrowth (GO) is a pathology with important aesthetic and functional implications and with a multifactorial pathogenesis. Incriminated etiological factors include antihypertensive, antiepileptic and immunosuppressant medication. We aimed to evaluate the induction of gingival overgrowth on experimental rats, depending on the drug type, dose and duration. In the research conducted by us, the increase in gingival tissue production occurred gradually, depending on the administered medication and the time elapsed after its start...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27913649/identification-and-function-of-fibrocytes-in-skeletal-muscle-injury-repair-and-muscular-dystrophy
#15
Xingyu Wang, Wanming Zhao, Richard M Ransohoff, Lan Zhou
We identified and characterized the function of CD45(+)/collagen I(+) fibrocytes in acutely injured skeletal muscle of wild-type (WT) and Ccr2(-/-) mice, and in quadriceps and diaphragm muscles of mdx(5cv) mice, a mouse model for Duchenne muscular dystrophy. Fibrocytes were not detected in peripheral blood of WT mice after acute muscle injury or mdx(5cv) mice. Fibrocytes were detected in acutely injured muscles and in mdx(5cv) quadriceps and diaphragm muscles. These cells expressed F4/80 and CCR2, and they were mostly Ly6C(lo) They expressed a low level of collagens but a high level of profibrotic growth factors as compared with i...
December 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27876193/effect-of-adenovirus-mediated-tgf-%C3%AE-1-gene-transfer-on-the-function-of-rabbit-articular-chondrocytes
#16
Yuan Tang, Jun Xiao, Yeyang Wang, Ming Li, Zhanjun Shi
BACKGROUND: Articular chondrocytes are important in maintaining normal cartilage tissue and preventing articular degeneration. Exogenous genes have previously been transduced into articular cells using adenoviral vectors to contribute to the maintenance of cell function. This study aimed to transfer the transforming growth factor-β1 gene (TGF-β1) into rabbit articular chondrocytes by adenovirus infection to elucidate its effects on cell function. METHODS: Rabbit chondrocytes were isolated and cultured both as monolayers and three-dimensional culture systems...
November 18, 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/27868006/circulating-fibrocytes-serve-as-a-marker-for-clinical-diagnosis
#17
COMMENT
Thuy Cao, Sheeja Rajasingh, Johnson Rajasingh
No abstract text is available yet for this article.
October 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27863082/allogeneic-platelet-rich-plasma-affects-monocyte-differentiation-to-dendritic-cells-causing-an-anti-inflammatory-microenvironment-putatively-fostering-the-wound-healing
#18
Andrea Papait, Ranieri Cancedda, Maddalena Mastrogiacomo, Alessandro Poggi
Autologous platelet rich plasma (PRP) is clinically used to induce repair of different tissues through the release of bioactive molecules. In some patients, the production of an efficient autologous PRP is unfeasible due to their compromised health. We developed an allogeneic PRP mismatched for AB0 and Rh antigens. To broadcast its clinical applications avoiding side effects the outcome of allogeneic PRP on immune response should be defined. Thus, we investigated whether PRP affected the differentiation of peripheral blood monocytes to dendritic cells upon stimulation with granulocyte monocyte colony stimulating factor and interleukin-4...
November 15, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27809916/immunological-profiling-of-patients-with-ulcerative-colitis-leads-to-identification-of-two-inflammatory-conditions-and-cd1a-as-a-disease-marker
#19
M Föhlinger, P Palamides, U Mansmann, F Beigel, M Siebeck, R Gropp
BACKGROUND: Conventional approaches to understand mechanisms underlying the development of pathological manifestations in ulcerative colitis (UC) mostly rely on identification of certain cell types and cytokines followed by verification of their roles in vitro and in vivo. In light of the highly dynamic processes in UC, requiring the cross talk of immune cells, epithelial-, endothelial-, muscle cells and fibrocytes, this approach might neglect temporal and spatial connectivity of individually differing inflammatory responses...
November 3, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27773739/basic-fibroblast-growth-factor-induces-angiogenic-properties-of-fibrocytes-to-stimulate-vascular-formation-during-wound-healing
#20
Miho Nakamichi, Yuri Akishima-Fukasawa, Chie Fujisawa, Tetsuo Mikami, Kiyoshi Onishi, Yoshikiyo Akasaka
The precise role of fibrocytes in angiogenesis in wounds remains unclear. We therefore demonstrated the specific changes in fibrocyte accumulation for angiogesis in basic fibroblast growth factor (bFGF)-treated wounds. bFGF-treated wounds exhibited marked formation of arterioles and inhibition of podoplanin(+) lymph vessels that were lacking in vascular endothelial growth factor-A-treated wounds. Real-time PCR in bFGF-treated wounds manifested enhanced expression of CD34, CD31, and bFGF mRNA and reduced expression of podoplanin and collagen type I, III, and IV mRNA...
October 20, 2016: American Journal of Pathology
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