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https://www.readbyqxmd.com/read/28213915/assessment-of-a-national-diabetes-education-program-diabetes-management-booklet-the-grade-experience
#1
Roshni Devchand, Christina Nicols, Joanne M Gallivan, Margaret Tiktin, Heidi Krause-Steinrauf, Mary Larkin, Diane M Tuncer
BACKGROUND AND PURPOSE: The National Diabetes Education Program created the 4 Steps to Manage Your Diabetes for Life (4 Steps) booklet to help patients with diabetes learn the basics of self-management and care recommendations. The purpose of this study is to explore the impact of 4 Steps on participants' diabetes management knowledge and self-efficacy in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE). METHODS: A sample of 348 adults with type 2 diabetes enrolled in GRADE was included in this analysis...
February 18, 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/28208151/bacillus-calmette-gu%C3%A3-rin-confers-neuroprotection-in-a-murine-model-of-japanese-encephalitis
#2
Sahil Kulkarni, Sandeepan Mukherjee, Anupama Pandey, Ritwik Dahake, Usha Padmanabhan, Abhay S Chowdhary
OBJECTIVE: Japanese encephalitis (JE) is a debilitating disease caused by infection with the JE virus (JEV; family: Flaviviridae), which leaves neurological sequelae in survivors but more often leads to mortality. Neurodegeneration caused by inflammation is the primary pathology behind the clinical manifestation of encephalitis caused by JEV. Bacillus Calmette-Guérin (BCG) has been used in immunoprophylaxis for tuberculosis and in the adjuvant therapy of many malignancies, and has exhibited neuroprotective activities in experimental models of Parkinson and Alzheimer disease...
February 17, 2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/28207929/optimisation-of-intestinal-microsomal-preparation-in-the-rat-a-systematic-approach-to-assess-the-influence-of-various-methodologies-on-metabolic-activity-and-scaling-factors
#3
Oliver J D Hatley, Christopher R Jones, Aleksandra Galetin, Amin Rostami-Hodjegan
The metabolic capacity of the intestine and its importance as the initial barrier to systemic exposure can lead to under-estimation of first-pass, and thus overestimation of oral bioavailability. However, the in vitro tools informing estimates of in vivo intestinal metabolism are limited by the complexity of the in vitro matrix preparation and uncertainty with the scaling factors for in vitro to in vivo extrapolation. A number of methods currently exist in the literature for the preparation of intestinal microsomes; however, the impact of key steps in the preparation procedure has not been critically assessed...
February 16, 2017: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/28206676/thoracic-ct-mri-co-registration-for-regional-pulmonary-structure-function-measurements-of-obstructive-lung-disease
#4
Fumin Guo, Sarah Svenningsen, Miranda Kirby, Dante P I Capaldi, Khadija Sheikh, Aaron Fenster, Grace Parraga
PURPOSE: Recent pulmonary imaging research has revealed that in patients with chronic obstructive pulmonary disease (COPD) and asthma, structural and functional abnormalities are spatially heterogeneous. This novel information may help optimize treatment in individual patients, monitor interventional efficacy and develop new treatments. Moreover, by automating the measurement of regional biomarkers for the 19 different anatomical lung segments, there is an opportunity to embed imaging biomarkers into clinically-acceptable clinical workflows and improve lung disease clinical care...
February 16, 2017: Medical Physics
https://www.readbyqxmd.com/read/28204887/determination-of-monoamine-neurotransmitters-in-zebrafish-danio-rerio-by-gas-chromatography-coupled-to-mass-spectrometry-with-a-two-step-derivatization
#5
Alvaro Aragon, Jessica Legradi, Ana Ballesteros-Gómez, Juliette Legler, Martin van Velzen, Jacob de Boer, Pim Leonards
A sensitive analytical method for the determination of monoamine neurotransmitters (MNTs) in zebrafish larvae was developed using gas chromatography coupled to mass spectrometry. Six MNTs were selected as target compounds for neurotoxicity testing. MNTs underwent a two-step derivatization with hexamethyldisilazane (HDMS) for O-silylation followed by N-methyl-bis-heptafluorobutyramide (MBHFBA) for N-perfluoroacylation. Derivatization conditions were optimized by an experimental design approach. Method validation showed linear calibration curves (r (2) > 0...
February 15, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28196473/2-7-million-samples-genotyped-for-hla-by-next-generation-sequencing-lessons-learned
#6
Gerhard Schöfl, Kathrin Lang, Philipp Quenzel, Irina Böhme, Jürgen Sauter, Jan A Hofmann, Julia Pingel, Alexander H Schmidt, Vinzenz Lange
BACKGROUND: At the DKMS Life Science Lab, Next Generation Sequencing (NGS) has been used for ultra-high-volume high-resolution genotyping of HLA loci for the last three and a half years. Here, we report on our experiences in genotyping the HLA, CCR5, ABO, RHD and KIR genes using a direct amplicon sequencing approach on Illumina MiSeq and HiSeq 2500 instruments. RESULTS: Between January 2013 and June 2016, 2,714,110 samples largely from German, Polish and UK-based potential stem cell donors have been processed...
February 14, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28194270/total-synthesis-of-a-key-series-of-vinblastines-modified-at-c4-that-define-the-importance-and-surprising-trends-in-activity
#7
Shouliang Yang, Kuppusamy Sankar, Colin K Skepper, Timothy J Barker, John C Lukesh, Daniel M Brody, Manuela M Brütsch, Dale L Boger
The total synthesis and evaluation of a key systematic series of vinblastines that incorporate the first deep-seated changes to the substituent at C4 are detailed. The synthetic approach features an expanded and redefined scope of a 1,3,4-oxadiazole [4 + 2]/[3 + 2] cycloaddition cascade in which electronically mismatched electron-deficient trisubstituted alkenes and unactivated trisubstituted alkenes were found to productively initiate the cycloaddition cascade with tethered electron-deficient 1,3,4-oxadiazoles...
February 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28192910/online-monitoring-of-enzymatic-reactions-using-time-resolved-desorption-electrospray-ionization-mass-spectrometry
#8
Si Cheng, Qiuhua Wu, He Xiao, Hao Chen
Electrospray ionization mass spectrometry (ESI-MS) is powerful for determining enzymatic reaction kinetics because of its soft ionization nature. However, it is limited to use ESI-favored solvents containing volatile buffers (e.g., ammonium acetate). In addition, lack of a quenching step for online ESI-MS reaction monitoring might introduce inaccuracy, due to the possible acceleration of reaction in the sprayed microdroplets. To overcome these issues, this study presents a new approach for online measuring enzymatic reaction kinetics using desorption electrospray ionization mass spectrometry (DESI-MS)...
February 9, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28191879/visualizing-the-early-stages-of-phagocytosis
#9
Ali Rashidfarrokhi, Veronica Richina, Fikadu G Tafesse
The mammalian body is equipped with various layers of mechanisms that help to defend itself from pathogen invasions. Professional phagocytes of the immune system - such as neutrophils, dendritic cells, and macrophages - retain the innate ability to detect and clear such invading pathogens through phagocytosis(1). Phagocytosis involves choreographed events of membrane reorganization and actin remodeling at the cell surface(2)(,)(3). Phagocytes successfully internalize and eradicate foreign molecules only when all stages of phagocytosis are fulfilled...
February 3, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28186746/unearthing-a-well-defined-highly-active-bimetallic-w-ti-pre-catalyst-anchored-on-a-single-silica-surface-for-metathesis-of-propane
#10
Manoja K Samantaray, Santosh Kavitake, Natalia Morlanes, Edy Abou-Hamad, Ali Hamieh, Raju Dey, Jean Marie Basset
Two compatible organometallic complexes, W(CH3)6 (1) followed by TiNp4 (2) were anchored on a highly dehydrox-ylated single silica support (silica-700) to synthesize a well-defined, bimetallic pre-catalyst [(≡Si-O-)W(Me)5 (≡Si-O-)Ti(Np)3](4). The pre-catalyst 4 was characterized at molecular level using advanced SOMC characterization tech-niques. Strong autocorrelation observed between methyl of W and Ti in 1H-1H Multiple Quantum NMR demonstrates that W and Ti species are in close proximity to each other...
February 10, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28183413/manuscript-development-and-publishing-a-5-step-approach
#11
Susan M Downey, Stephen A Geraci
Publications in peer-reviewed biomedical journals are essential for sharing knowledge and advancing healthcare. This article will articulate a 5-step approach for developing and publishing a manuscript, and provide academic clinicians with an instructional tool they can provide to their protégés and junior faculty. The authors attempt to distill existing advice for preparing manuscripts, which is found in myriad formats, combine these tutorials with their collective experience and present this approach for developing and publishing successfully a manuscript in a peer-reviewed journal...
February 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28183336/assessing-the-impact-of-intervention-strategies-against-taenia-solium-cysticercosis-using-the-epicyst-transmission-model
#12
Peter Winskill, Wendy E Harrison, Michael D French, Matthew A Dixon, Bernadette Abela-Ridder, María-Gloria Basáñez
BACKGROUND: The pork tapeworm, Taenia solium, and associated human infections, taeniasis, cysticercosis and neurocysticercosis, are serious public health problems, especially in developing countries. The World Health Organization (WHO) has set goals for having a validated strategy for control and elimination of T. solium taeniasis/cysticercosis by 2015 and interventions scaled-up in selected countries by 2020. Timely achievement of these internationally-endorsed targets requires that the relative benefits and effectiveness of potential interventions be explored rigorously within a quantitative framework...
February 9, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28180011/the-challenges-of-living-with-an-implantable-cardioverter-defibrillator-a-qualitative-study
#13
Mohammad Abbasi, Reza Negarandeh, Reza Norouzadeh, Amir Reza Shojae Mogadam
BACKGROUND: Dysrhythmia is one of the most common causes of sudden cardiac death worldwide. An implantable cardioverter defibrillator is the most effective method of treatment for dysrhythmias causing cardiac arrest. However, living with an implantable cardioverter defibrillator is associated with challenges such as fear, anxiety, and depression. OBJECTIVES: The purpose of this study was to identify the challenges of living with an implantable cardioverter defibrillator...
October 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28179948/synthesis-of-structurally-diverse-3-4-dihydropyrimidin-2-1h-ones-via-sequential-biginelli-and-passerini-reactions
#14
Andreas C Boukis, Baptiste Monney, Michael A R Meier
The Biginelli reaction was combined with the Passerini reaction for the first time in a sequential multicomponent tandem reaction approach. After evaluation of all possible linker components and a suitable solvent system, highly functionalized dihydropyrimidone-α-acyloxycarboxamide compounds were obtained in good to excellent yields. In a first reaction step, different 3,4-dihydropyrimidin-2(1H)-one acids were synthesized, isolated and fully characterized. These products were subsequently used in a Passerini reaction utilizing a dichloromethane/dimethyl sulfoxide solvent mixture...
2017: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28178829/the-collision-of-a-hypervelocity-massive-projectile-with-free-standing-graphene-investigation-of-secondary-ion-emission-and-projectile-fragmentation
#15
Sheng Geng, Stanislav V Verkhoturov, Michael J Eller, Serge Della-Negra, Emile A Schweikert
We present here the study of the individual hypervelocity massive projectiles (440-540 keV, 33-36 km/s Au400(4+) cluster) impact on 1-layer free-standing graphene. The secondary ions were detected and recorded separately from each individual impact in the transmission direction using a time-of-flight mass spectrometer. We observed C1-10(±) ions emitted from graphene, the projectiles which penetrated the graphene, and the Au1-3(±) fragment ions in mass spectra. During the projectile-graphene interaction, the projectile loses ∼15% of its initial kinetic energy (∼0...
February 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28177637/synthesis-of-the-pentacyclic-core-of-citreamicin-%C3%AE
#16
Shawn Blumberg, Stephen F Martin
The citreamicins comprise a novel class of polycyclic xanthone natural products that have not yet yielded to total synthesis. A concise 11-step synthesis of the pentacyclic core of citreamicin η is now reported that features the use of a general approach for the synthesis of 1,4-dioxygenated xanthones. The synthesis also showcases improved techniques for effecting regioselective bromination of certain substituted phenols and coupling of acetylides with hindered ketones.
February 8, 2017: Organic Letters
https://www.readbyqxmd.com/read/28176916/is-there-a-way-for-clinical-teachers-to-assist-struggling-learners-a-synthetic-review-of-the-literature
#17
REVIEW
Elisabeth Boileau, Christina St-Onge, Marie-Claude Audétat
Struggling medical trainees pose a challenge to clinical teachers, since these learners warrant closer supervision that is time-consuming and competes with time spent on patient care. Clinical teachers' perception that they are ill equipped to address learners' difficulties efficiently may lead to delays or even lack of remediation for these learners. Because of the paucity of evidence to guide best practices in remediation, the best approach to guide clinical teachers in the field remains to be established...
2017: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/28174565/evaluation-of-molecular-methods-for-the-detection-and-quantification-of-pathogen-derived-nucleic-acids-in-sediment
#18
Kata Farkas, Francis Hassard, James E McDonald, Shelagh K Malham, Davey L Jones
The accurate detection of pathogens in environmental matrices, such as sediment, is critical in understanding pathogen fate and behavior in the environment. In this study, we assessed the usefulness of methods for the detection and quantification of Vibrio spp. and norovirus (NoV) nucleic acids in sediment. For bacteria, a commonly used direct method using hexadecyltrimethylammonium bromide (CTAB) and phenol-chloroform-isoamyl alcohol (PCI) extraction was optimized, whereas for NoV, direct and indirect (virus elution-concentration) methods were evaluated...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28171789/optimized-multi-step-nmr-crystallography-approach-for-structural-characterization-of-a-stable-quercetin-solvate
#19
Xenia Filip, Maria Miclaus, Flavia Martin, Claudiu Filip, Ioana Georgeta Grosu
Herein we report the preparation and solid state structural investigation of the 1,4-dioxane-quercetin solvate. NMR crystallography methods were employed for crystal structure determination of the solvate from microcrystalline powder. The stability of the compound relative to other reported quercetin solvates is discussed and found to be in perfect agreement with the hydrogen bonding networks/supra-molecular architectures formed in each case. It is also clearly shown that NMR crystallography represents an ideal analytical tool in such cases when hydrogen-bonding networks are required to be constrained at a high accuracy level...
January 31, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28170011/synthesis-and-evaluation-of-new-copper-ketoiminate-precursors-for-a-facile-and-additive-free-solution-based-approach-to-nanoscale-copper-oxide-thin-films
#20
Sarah Karle, Detlef Rogalla, Arne Ludwig, Hans-Werner Becker, Andreas Dirk Wieck, Markus Grafen, Andreas Ostendorf, Anjana Devi
Novel copper ketoiminate compounds were synthesized and for the first time applied for additive-free solution-based deposition of nanoscale copper oxide thin films. The two closely related compounds, namely the bis[4-(2-ethoxyethyl-imino)-3-pentanonato]copper, [Cu(EEKI)2], and bis[4-(3-methoxypropylimino)-3-pentanonato]copper, [Cu(MPKI)2], were characterized by means of elemental and thermogravimetric analysis (TGA), as well as electron impact mass spectrometry (EI-MS). The advantages of these compounds are that they are liquid and possess excellent solubility in common organic solvents in addition to an optimum reactivity towards ambient moisture that enables a facile solution-based approach to nanoscale copper oxide thin films...
February 7, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
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