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https://www.readbyqxmd.com/read/28654928/risk-stratification-of-patients-with-crohn-s-disease-a-retrospective-analysis-of-clinical-decision-making-and-its-impact-on-long-term-outcome
#1
Mahmoud Mosli, Hanadi Sabbahi, Hind Alyousef, Mada Abdulhaq, Afnan Hadadi, Emad Aljahdali, Hani Jawa, Salem Bazarah, Yousif Qari
BACKGROUND AND AIMS: Complications such as need for bowel resections and hospitalization due to Crohn's disease (CD) occur when disease activity persists due to ineffective therapy. Certain "high-risk" features require an early introduction of anti-tumor necrosis factor-α therapy to prevent such complications. We aim to evaluate the prevalence of "high-risk" features among a cohort of patients with CD and examine the association between discordance of early therapy with baseline risk stratification and disease outcome...
June 28, 2017: Digestive Diseases
https://www.readbyqxmd.com/read/28654667/development-and-initial-implementation-of-the-dynamic-assessment-treatment-algorithm-data
#2
Katya C Fernandez, Aaron J Fisher, Cyrus Chi
Given the recent increase in transdiagnostic research, it is important to discern how dimensional models of psychopathology could be used to guide personalized, dynamic assessment and treatment of symptoms. Using the person-specific approach described by Fisher (2015), we devised an initial 4-step algorithm for devising a treatment plan based on modular cognitive behavioral therapy using results obtained from within-person factor analyses and dynamic factor models. Then, we describe the improvement and digitization of the algorithm, termed Dynamic Assessment Treatment Algorithm (DATA)...
2017: PloS One
https://www.readbyqxmd.com/read/28654610/what-s-new-in-syndromic-craniosynostosis-surgery
#3
Jesse A Taylor, Scott P Bartlett
LEARNING OBJECTIVES: After studying this article, the participant should be able to: 1. Understand the role of prenatal screening and counseling of parents of unborn children with syndromic craniosynostosis. 2. Recognize the genetic abnormalities, craniofacial phenotype, associated anomalies, and challenges associated with each of the five major forms of syndromic craniosynostosis. 3. Identify the pros and cons associated with timing and types of cranial vault remodeling techniques in this patient population...
July 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28654592/preventing-soft-tissue-triangle-collapse-in-modern-rhinoplasty
#4
Carey F Campbell, Ronnie A Pezeshk, Deniz S Basci, Jack F Scheuer, David A Sieber, Rod J Rohrich
The unique anatomy of the soft-tissue triangle makes it prone to notching in primary, secondary, and reconstructive rhinoplasty. Understanding the anatomy of the region is critical to appropriate treatment. This article is meant to further clarify the anatomy of the soft-tissue triangle and to present the senior author's (R.J.R.) approach to proactive correction and prevention of soft-tissue triangle notching through five key steps: (1) precise dissection and incision placement, (2) providing internal support with cartilage grafting if needed, (3) closure of dead space, (4) avoiding undue tension during closure, and (5) providing external support postoperatively...
July 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28654481/stepping-up-to-rethink-the-future-of-rehabilitation-iv-step-considerations-and-inspirations
#5
Teresa Jacobson Kimberley, Iona Novak, Lara Boyd, Eileen Fowler, Deborah Larsen
BACKGROUND AND PURPOSE: The IV STEP conference challenged presenters and participants to consider the state of science in rehabilitation, highlighting key area of progress since the previous STEP conference related to prediction, prevention, plasticity, and participation in rehabilitation. KEY POINTS: Emerging from the thought-provoking discussions was recognition of the progress we have made as a profession and a call for future growth. In this summary article, we present a recap of the key points and call for action...
July 2017: Pediatric Physical Therapy
https://www.readbyqxmd.com/read/28653051/posterior-indirect-adhesive-%C3%A2-restorations-updated-indications-%C3%A2-and-the-morphology-driven-%C3%A2-preparation-technique
#6
Marco Veneziani
The aim of this article is to identify the indications for adhesively cemented restorations and to provide a correct step-by-step protocol for clinicians. New cavity preparation principles are based on morphological considerations in terms of geometry (maximum profile line and inclination of cusp lines), and structure (dentin concavity and enamel convexity). In this article, we discuss previous preparation concepts that were not designed purely for adhesive restorations and were therefore not conservative enough or suitable for adhesive procedures...
2017: International Journal of Esthetic Dentistry
https://www.readbyqxmd.com/read/28651998/elephant-trunk-technique-with-a-handmade-skirted-tube-graft-how-do-we-prepare-it
#7
Gökhan Lafci, Eren Gunertem, Serpil Sahin, Garip Altintas, Mahmut Ulaş
The surgical treatment of diffuse thoracic aortic pathologies remains a challenge in aortic surgery for surgeons. Traditionally, these aortic diseases are treated with a two-step approach known as the "elephant trunk procedure".(1) This technique gives us an opportunity for the construction of the distal anastomosis during the initial operation. However, this staged approach is associated with a substantial overall mortality and morbidity (2,3) In order to improve the outcomes, few single-stage repair methods have been tried...
June 23, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28651432/controlled-intercalation-and-chemical-exfoliation-of-layered-metal-organic-frameworks-using-a-chemically-labile-intercalating-agent
#8
Yanjun Ding, Ying-Pin Chen, Xinlei Zhang, Liang Chen, Zhaohui Dong, Hai-Long Jiang, Hangxun Xu, Hong-Cai Zhou
Creating ordered two-dimensional (2D) metal-organic framework (MOF) nanosheets has attracted extensive interest. However, it still remains a great challenge to synthesize ultrathin 2D MOF nanosheets with controlled thickness in high yields. In this work, we demonstrate a novel intercalation and chemical exfoliation approach to obtain MOF nanosheets from intrinsically layered MOF crystals. This approach involves two steps: firstly, layered porphyrin MOF crystals are intercalated with 4,4'-dipyridyl disulfide through coordination bonding with the metal nodes; subsequently, selective cleavage of the disulfide bond induces the exfoliation of intercalated MOF crystals, leading to individual, freestanding MOF nanosheets...
June 27, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28650684/intentional-ingestion-of-elemental-mercury-requiring-multi-step-decontamination-and-prophylactic-appendectomy-a-case-report-and-treatment-proposal
#9
Andrea Michielan, Azzurra Schicchi, Roberto Cappuccio, Davide Lonati, Francesca Lamboglia, Alessandra Vitalba, Alessandro Caroli, Marta Crevani, Carlo A Locatelli, Giorgio Betetto
BACKGROUND: Ingestion of elemental mercury (Hg0) is considered non-toxic. After massive ingestion, local intestinal complications may develop: retention within appendix is quite frequent but treatment is debated. We describe a case of intentional ingestion of Hg0 requiring multi-step decontamination and prophylactic appendectomy. Case detail: A 19-year-old woman was admitted to ED for abdominal pain. History revealed ingestion of large amount of Hg0 as suicide attempt. To prevent absorption, facilitate elimination, and avoid complications a conservative approach was started...
June 26, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28650650/prodrugs-of-pyrazolo-3-4-d-pyrimidines-from-library-synthesis-to-evaluation-as-potential-anticancer-agents-in-an-orthotopic-glioblastoma-model
#10
Giulia Vignaroli, Giulia Iovenitti, Claudio Zamperini, Federica Coniglio, Pierpaolo Calandro, Alessio Molinari, Anna Lucia Fallacara, Andrea Sartucci, Alessia Calgani, David Colecchia, Andrea Mancini, Claudio Festuccia, Elena Dreassi, Massimo Valoti, Francesca Musumeci, Mario Chiariello, Adriano Angelucci, Maurizio Botta, Silvia Schenone
Pyrazolo[3,4-d]pyrimidines are potent protein kinase inhibitors with promising antitumor activity but suboptimal aqueous solubility, consequently worth to be further optimized. Herein, we present the one-pot two-step procedure for the synthesis of a set of pyrazolo[3,4-d]pyrimidine prodrugs (1a-9a,e) with higher aqueous solubility and enhanced pharmacokinetic and therapeutic properties. ADME studies demonstrated for the most promising prodrugs a better aqueous solubility, a favorable hydrolysis in human and murine serum and an increased ability to cross cell membranes with respect to the parental drugs, explaining their better 24h in vitro cytotoxicity against human glioblastoma U87 cell line...
June 26, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28648774/the-carmat-bioprosthetic-total-artificial-heart-is-associated-with-early-hemostatic-recovery-and-no-acquired-von-willebrand-syndrome-in-calves
#11
David M Smadja, Sophie Susen, Antoine Rauch, Bernard Cholley, Christian Latrémouille, Daniel Duveau, Luca Zilberstein, Denis Méléard, Marie-Fazia Boughenou, Eric Van Belle, Pascale Gaussem, Antoine Capel, Piet Jansen, Alain Carpentier
OBJECTIVES: To determine hemostasis perturbations, including von Willebrand factor (VWF) multimers, after implantation of a new bioprosthetic and pulsatile total artificial heart (TAH). DESIGN: Preclinical study SETTING: Single-center biosurgical research laboratory. PARTICIPANTS: Female Charolais calves, 2-to-6 months old, weighing 102-to-122 kg. INTERVENTIONS: Surgical implantation of TAH through a mid-sternotomy approach...
March 1, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28646966/a-systematic-approach-to-diagnosing-intra-thoracic-tuberculosis-in-children
#12
Carlos M Perez-Velez, Claudia L Roya-Pabon, Ben J Marais
Children suffer a huge and often underappreciated burden of disease in tuberculosis (TB) endemic countries. Major hurdles include limited awareness among health care workers, poor integration of TB into maternal and child health approaches, diagnostic difficulties and a lack of child-friendly treatment options. Accurate disease diagnosis is particularly difficult in young and vulnerable children who tend to develop paucibacillary disease and are unable to produce an expectorated sputum sample. In addition, access to chest radiography is problematic in resource-limited settings...
June 2017: Journal of Infection
https://www.readbyqxmd.com/read/28644013/a-simple-approach-to-prepare-carboxycellulose-nanofibers-from-untreated-biomass
#13
Priyanka R Sharma, Ritika Joshi, Benjamin S Hsiao
A simple approach was developed to prepare carboxycellulose nanofibers directly from untreated biomass using nitric acid or nitric acid-sodium nitrite mixtures. Experiments indicated that this approach greatly reduced the need for multi-chemicals, and offered significant benefits in lowering the consumption of water and electric energy, when compared with conventional multiple-step processes at bench scale (e.g. TEMPO oxidation). Additionally, the effluent produced by this approach could be efficaciously neutralized using base to produce nitrogen-rich salts as fertilizers...
June 23, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28643514/nitroalkenes-as-latent-1-2-biselectrophiles-a-multicatalytic-approach-for-the-synthesis-of-1-4-diketones-and-their-application-in-a-4-step-one-pot-reaction-to-polysubstituted-pyrroles
#14
Patrick J W Fuchs, Kirsten Zeitler
A NHC-catalyzed Nitro-Stetter/elimination/Stetter reaction sequence employs nitroalkenes as latent 1,2-dication synthons providing a novel access to highly useful symmetrical and unsymmetrical 2-aryl substituted 1,4 diketone building blocks from commercially available aldehyde precursors. For less activated (aliphatic) aldehydes a cooperative catalytic strategy has been developed via the merger of NHC and H-bonding catalysis. To further showcase the versatility of our approach a great variety of these unprecedented 1,4 diketones are used to efficiently synthesize polysubstituted pyrroles - including those with hetaryl substituents - in good to excellent yields in a multicatalytic metal-free, 4-step one-pot-cascade reaction under mild, yet robust conditions...
June 23, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28642784/novel-miscanthus-germplasm-based-value-chains-a-life-cycle-assessment
#15
Moritz Wagner, Andreas Kiesel, Astley Hastings, Yasir Iqbal, Iris Lewandowski
In recent years, considerable progress has been made in miscanthus research: improvement of management practices, breeding of new genotypes, especially for marginal conditions, and development of novel utilization options. The purpose of the current study was a holistic analysis of the environmental performance of such novel miscanthus-based value chains. In addition, the relevance of the analyzed environmental impact categories was assessed. A Life Cycle Assessment was conducted to analyse the environmental performance of the miscanthus-based value chains in 18 impact categories...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28642635/virtual-screening-following-rational-drug-design-based-approach-for-introducing-new-anti-amyloid-beta-aggregation-agent
#16
Garshasb Rigi, Mohammad Vala Ashdar Nakhaei, Hoda Eidipour, Arshia Najimi, Fahimeh Tajik, Niloufar Taher, Kamran Yarahmadi
Amyloid β (Aβ) sheets aggregations is the main reason of Alzheimer disease. The interacting areas between monomers are residue number 38 to 42. Inhibition of interaction between Aβ molecules prevents plaque formation. In the present study, we have performed a high-throughput virtual screening among ZINC database and top 1000 hits were checked again regarding binding affinity by AutoDock software. Top 4 successive second step screening hits was considered for drug design purpose against aggregation site of Aβ molecules...
2017: Bioinformation
https://www.readbyqxmd.com/read/28640075/maximum-voltage-gradient-technique-for-optimization-of-ablation-for-typical-atrial-flutter-with-zero-fluoroscopy-approach
#17
Karol Deutsch, Janusz Śledź, Mariusz Mazij, Bartosz Ludwik, Michał Labus, Dariusz Karbarz, Bernadetta Pasicka, Michał Chrabąszcz, Arkadiusz Śledź, Monika Klank-Szafran, Laura Vitali-Sendoz, Tomasz Kameczura, Jerzy Śpikowski, Piotr Stec, Marek Ujda, Sebastian Stec
Radiofrequency catheter ablation (RFCA) is an established effective method for the treatment of typical cavo-tricuspid isthmus (CTI)-dependent atrial flutter (AFL). The introduction of 3-dimensional electro-anatomic systems enables RFCA without fluoroscopy (No-X-Ray [NXR]). The aim of this study was to evaluate the feasibility and effectiveness of CTI RFCA during implementation of the NXR approach and the maximum voltage-guided (MVG) technique for ablation of AFL.Data were obtained from prospective standardized multicenter ablation registry...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28639338/registration-strategies-for-multi-modal-whole-body-mri-mosaicing
#18
Jakub Ceranka, Mathias Polfliet, Frédéric Lecouvet, Nicolas Michoux, Johan de Mey, Jef Vandemeulebroucke
PURPOSE: To test and compare different registration approaches for performing whole-body diffusion-weighted (wbDWI) image station mosaicing, and its alignment to corresponding anatomical T1 whole-body image. METHODS: Four different registration strategies aiming at mosaicing of diffusion-weighted image stations, and their alignment to the corresponding whole-body anatomical image, were proposed and evaluated. These included two-step approaches, where diffusion-weighted stations are first combined in a pairwise (Strategy 1) or groupwise (Strategy 2) manner and later non-rigidly aligned to the anatomical image; a direct pairwise mapping of DWI stations onto the anatomical image (Strategy 3); and simultaneous mosaicing of DWI and alignment to the anatomical image (Strategy 4)...
June 21, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28636449/zika-virus-in-ontario-evaluating-a-rapid-risk-assessment-tool-for-emerging-infectious-disease-threats
#19
Ryan Van Meer, Karin Hohenadel, Alanna Fitzgerald-Husek, Bryna Warshawsky, Doug Sider, Brian Schwartz, Mark P Nelder
To determine the Ontario-specific risk of local and travel-related Zika virus transmission in the context of a public health emergency of international concern, Public Health Ontario (PHO) completed a rapid risk assessment (RRA) on January 29, 2016, using a newly developed RRA guidance tool. The RRA concluded that risk of local mosquito-borne transmission was low, with a high risk of imported cases through travel. The RRA was updated 3 times based on predetermined triggers. An independent evaluation assessed both the application of the RRA guidance tool (process evaluation) and the usefulness of the RRA (outcome evaluation)...
May 2017: Health Security
https://www.readbyqxmd.com/read/28634851/multi-step-biocatalytic-depolymerization-of-lignin
#20
Pere Picart, Haifeng Liu, Philipp M Grande, Nico Anders, Leilei Zhu, Jürgen Klankermayer, Walter Leitner, Pablo Domínguez de María, Ulrich Schwaneberg, Anett Schallmey
Lignin is a biomass-derived aromatic polymer that has been identified as a potential renewable source of aromatic chemicals and other valuable compounds. The valorization of lignin, however, represents a great challenge due to its high inherent functionalization, what compromises the identification of chemical routes for its selective depolymerization. In this work, an in vitro biocatalytic depolymerization process is presented, that was applied to lignin samples obtained from beech wood through OrganoCat pretreatment, resulting in a mixture of lignin-derived aromatic monomers...
June 21, 2017: Applied Microbiology and Biotechnology
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