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https://www.readbyqxmd.com/read/29933343/impact-of-a-graded-exercise-program-on-vo2peak-and-survival-in-heart-failure-patients
#1
Johan A Snoek, Thijs M H Eijsvogels, Arnoud W J van 't Hof, Eva Prescott, Maria T Hopman, Evelien Kolkman, Ed P de Kluiver
INTRODUCTION: Although exercise therapy has the potential to improve health outcomes of patients with Chronic Heart Failure (CHF), less than 50% of patients adhere to prescribed physical activity guidelines one year after Cardiac Rehabilitation (CR). We aimed to assess the effects of an extended CR program with 12-months of Graded Exercise Therapy (GET) and resistance exercise training (RT) on exercise capacity and long-term survival in patients with CHF. METHODS: This prospective cohort study included sixty CHF patients between 2009 and 2010...
June 21, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29931724/overexpression-of-a-glutathione-s-transferase-mdgst-and-a-galactosyltransferase-like-gene-mdgt1-is-responsible-for-imidacloprid-resistance-in-house-flies
#2
William R Reid, Haina Sun, James J Becnel, Andrew G Clark, Jeffrey G Scott
BACKGROUND: Neonicotinoids are the largest class of insecticides and are used for control of house fly populations at animal production facilities throughout the world. There have been several reports of neonicotinoid resistance in house fly populations, but identification of the factors involved in resistance has proven challenging. The KS8S3 population of house flies is highly resistant to the neonicotinoid insecticide imidacloprid due to two factors: one on chromosome 3 and one on chromosome 4...
June 21, 2018: Pest Management Science
https://www.readbyqxmd.com/read/29930231/associations-between-functional-milestones-and-psychiatric-admissions-in-an-urban-area-utility-of-a-cluster-analytical-approach
#3
Cristiana Montemagni, Tiziana Frieri, Vincenzo Villari, Paola Rocca
BACKGROUND: The purpose of the study was to identify homogenous subgroups, based upon achievement of two functional milestones (marriage and employment) and Global Assessment of Functioning (GAF) score in a sample of 848 acute patients admitted to the Psychiatric Emergency Service (PES) of the Città della Salute e della Scienza di Torino, during a 24-months period. SUBJECTS AND METHODS: A two-step cluster-analysis, using GAF total score and the achievements in the two milestones as input data was performed...
June 2018: Psychiatria Danubina
https://www.readbyqxmd.com/read/29929482/small-scale-implementation-with-pragmatic-process-evaluation-a-model-developed-in-primary-health-care
#4
Kirsti Malterud, Aase Aamland, Kristina Riis Iden
BACKGROUND: Research often fails to impose substantial shifts in clinical practice. Evidence-based health care requires implementation of documented interventions, with implementation research as a science-informed strategy to identify core experiences from the process and share preconditions for achievement. Evidence developed in hospital contexts is often neither relevant nor feasible for primary care. Different evidence types may constitute a point of departure, stretching and testing the transferability of the intervention by piloting it in primary care...
June 21, 2018: BMC Family Practice
https://www.readbyqxmd.com/read/29929070/effects-of-caffeic-acid-phenethyl-ester-application-on-dentin-mmp-2-stability-of-bond-strength-and-failure-mode-of-total-etch-and-self-etch-adhesive-systems
#5
Vivianne Oliveira Pedrosa, Fabiana Mantovani Gomes França, Cecilia Pedroso Turssi, Flávia Lucisano Botelho do Amaral, Lucas Novaes Teixeira, Elizabeth Ferreira Martinez, Roberta Tarkany Basting
OBJECTIVE: Investigate the long-term effect of dentin pretreatment with 0.05 or 0.1% caffeic acid phenethyl ester (CAPE) on (1) bond strength of resin composite to dentin by a three-step etch-and-rinse (Adper Scotchbond Multipurpose/ ASB) or a two-step self-etch adhesive system (Clearfil SE Bond/ CSE), (2) their fracture mode, (3) the micromorphological features of the hybrid layer formed; and (4) the level of MMP-2 in dentin (after application, using a correlative immunoexpression/quantification approach)...
June 11, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29926809/enhancing-adsorption-capacity-while-maintaining-specific-recognition-performance-of-mesoporous-silica-a-novel-imprinting-strategy-with-amphiphilic-ionic-liquid-as-surfactant
#6
Shichao Ding, Zhiling Li, Yuan Cheng, Chunbao Du, Junfeng Gao, Yong-Wei Zhang, Nan Zhang, Zhaotong Li, Ninghui Chang, Xiaoling Hu
In order to facilitate the broad applications of molecular recognition materials in biomedical areas, it is critical to enhance their adsorption capacity while maintaining their excellent recognition performance. In this work, we designed and synthesized well-defined peptide-imprinted mesoporous silica (PIMS) for specific recognition of an immunostimulating hexapeptide from human casein (IHHC) by using amphiphilic ionic liquid as the surfactant to anchor IHHC via a combination of one step sol-gel method and docking oriented imprinting approach...
June 21, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29925492/a-teledermatology-scale-up-framework-and-roadmap-for-sustainable-scaling-evidence-based-development
#7
Laticha Elizabeth Marolana Walters, Richard Ernest Scott, Maurice Mars
BACKGROUND: The objectives of South Africa's electronic health (eHealth) strategy recognize the value proposition that telemedicine practices hold for rural and urban referrals, but a lack of accepted and formalized scale-up has impeded realization of benefits. While both synchronous and asynchronous teledermatology exist, these remain localized and not scaled-up. Skin pathology is often the first sign of an HIV/AIDS infection, which remains a major cause of morbidity and mortality in South Africa...
June 20, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29922989/-tips-and-technical-issues-for-performing-transoral-endoscopic-thyroidectomy-with-vestibular-approach-toetva-a-novel-scarless-technique-for-neck-surgery
#8
REVIEW
R Zorron, C Bures, A Brandl, P Seika, V Müller, M Alkhazraji, J Pratschke, M Mogl
BACKGROUND: Nowadays, minimally invasive thyroid and parathyroid gland resections for both benign and malignant tumors are rarely performed. Recently, promising new endoscopic transoral approaches to the anterior neck have been described with good results and few complications. This study describes the first clinical series in Germany using transoral endoscopic thyroidectomy-vestibular approach (TOETVA) and identifies technical issues and solutions. METHODS: The technique is indicated for hemithyroidectomy in patients without pre-existing neck operations...
June 19, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29921244/subjective-and-objective-assessment-of-sedentary-behavior-among-college-employees
#9
Samuel Headley, Jasmin Hutchinson, Sarah Wooley, Kristen Dempsey, Kelvin Phan, Gregory Spicer, Xanne Janssen, Jerold Laguilles, Tracey Matthews
BACKGROUND: High levels of sedentary behavior are linked to increased mortality. In the United States, individuals spend 55-70% of their waking day being sedentary. Since most individuals spend large portions of their daily lives at work, quantifying the time engaged in sedentary behavior at work is emerging as an important health determinant. Studies profiling academic institutions, where a variety of personnel with diverse job descriptions are employed, are limited. Available studies focus mostly on subjective methods, with few using objective approaches...
June 19, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29920681/laparoscopic-proximal-gastrectomy-for-gastric-neoplasms
#10
Moshim Kukar, Emmanuel Gabriel, Kfir Ben-David, Steven N Hochwald
BACKGROUND: For cancers of the distal gastroesophageal junction or the proximal stomach, proximal gastrectomy can be performed. It is associated with several perioperative benefits compared with total gastrectomy. The use of laparoscopic proximal gastrectomy (LPG) has become an increasingly popular approach for select tumors. METHODS: We describe our method of LPG, including the preoperative work-up, illustrated depictions of the key steps of the surgery, and our postoperative pathway...
June 19, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29920591/simultaneous-determination-of-paracetamol-and-chlorzoxazone-in-their-combined-pharmaceutical-formulations-by-reversed-phase-capillary-liquid-chromatography-using-a-polymethacrylate-monolithic-column
#11
Mutaz E Salih, Ahmad Aqel, Babiker Y Abdulkhair, Zeid A ALOthman, Mohamad A Abdulaziz, A Yacine Badjah-Hadj-Ahmed
Recently, analytical separation techniques have the potential toward green approaches to reduce the environmental impact. This study focuses on the development of an analytical method for the determination of paracetamol and chlorzoxazone in their pharmaceutical combination. The separation was achieved using a home-made capillary column (0.10 mm i.d. × 200 mm length) filled with porous cross-linked hexyl polymethacrylate as monolithic stationary phase. The method proved to be simple, fast, sensitive, efficient, cost-effective and green approach due to the combination of the amazing properties of a monolithic material and a miniaturized liquid chromatography, which would be considered as a step toward reducing the analytical costs and the environmental impact of chromatographic applications...
June 16, 2018: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/29920581/a-multidisciplinary-approach-to-biopsychosocial-care-for-adults-with-inflammatory-bowel-disease-a-pilot-study
#12
Chang Kyun Lee, Gil Y Melmed, Amy Mann, Itai Danovitch, Rebecca Hedrick, Dermot P B McGovern, Stephan Targan, David Shih, Eric Vasiliauskas, Waguih William IsHak, Edward Feldman
Background: This study reports on the logistics and feasibility of a novel multidisciplinary approach to biopsychosocial care at a tertiary adult inflammatory bowel disease (IBD) center. Methods: Consecutive patients referred for a new IBD consultation completed the following self-assessments: the Short Form-12, the Patient Reported Outcome Measurement Information System (PROMIS) Global Health Scale, the World Health Organization Disability Assessment Schedule 2...
June 15, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29916057/investigation-into-the-emerging-role-of-the-basic-amino-acid-l-lysine-in-enhancing-solubility-and-permeability-of-bcs-class-ii-and-bcs-class-iv-drugs
#13
Hamdy Abdelkader, Zeinab Fathalla
BACKGROUND: The search for a simple and scalable approach that can improve the two key biopharmaceutical processes (solubility and permeability) for BCS Class II and BCS Class IV has still been unmet need. PURPOSE: In this study, L-lysine was investigated as a potential excipient to tackle problems with solubility and permeability. Bendazac (Class II); quercetin and rutin (Class IV) were employed. METHODS: Drugs-lysine complexes in 1:1 M ratios were prepared by co-precipitation and co-grinding; characterized for solubility, partition coefficient, DSC, FTIR, SEM, dissolution rate and permeability...
June 18, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29914458/developing-a-realist-theory-of-psychosocial-rehabilitation-the-clubhouse-model
#14
Christina Mutschler, Jen Rouse, Kelly McShane, Criss Habal-Brosek
BACKGROUND: Psychosocial rehabilitation is a service that supports recovery from mental illness by providing opportunities for skill development, self-determination, and social interaction. One type of psychosocial rehabilitation is the Clubhouse model. The purpose of the current project was to create, test, and refine a realist theory of psychosocial rehabilitation at Progress Place, an accredited Clubhouse. METHOD: Realist evaluation is a theory driven evaluation that uncovers contexts, mechanisms, and outcomes, in order to develop a theory as to how a program works...
June 13, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29910988/sorption-to-soil-biochar-and-compost-is-prediction-to-multicomponent-mixtures-possible-based-on-single-sorbent-measurements
#15
Melanie Kah, Gabriel Sigmund, Pedro Luis Manga Chavez, Lucie Bielská, Thilo Hofmann
Amendment with biochar and/or compost has been proposed as a strategy to remediate soil contaminated with low levels of polycyclic aromatic hydrocarbons. The strong sorption potential of biochar can help sequestering contaminants while the compost may promote their degradation. An improved understanding of how sorption evolves upon soil amendment is an essential step towards the implementation of the approach. The present study reports on the sorption of pyrene to two soils, four biochars and one compost. Detailed isotherm analyzes across a wide range of concentration confirmed that soil amendments can significantly increase the sorption of pyrene...
2018: PeerJ
https://www.readbyqxmd.com/read/29910730/binding-thermodynamics-and-selectivity-of-a-non-peptide-antagonist-to-the-melanocortin-4-receptor
#16
Noureldin Saleh, Gunnar Kleinau, Nicolas Heyder, Timothy Clark, Peter W Hildebrand, Patrick Scheerer
The melanocortin-4 receptor (MC4R) is a potential drug target for treatment of obesity, anxiety, depression, and sexual dysfunction. Crystal structures for MC4R are not yet available, which has hindered successful structure-based drug design. Using microsecond-scale molecular-dynamics simulations, we have investigated selective binding of the non-peptide antagonist MCL0129 to a homology model of human MC4R (hMC4R). This approach revealed that, at the end of a multi-step binding process, MCL0129 spontaneously adopts a binding mode in which it blocks the agonistic-binding site...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29910710/supplemental-stimulation-improves-swing-phase-kinematics-during-exoskeleton-assisted-gait-of-sci-subjects-with-severe-muscle-spasticity
#17
Andrew Ekelem, Michael Goldfarb
Spasticity is a common comorbidity associated with spinal cord injury (SCI). Robotic exoskeletons have recently emerged to facilitate legged mobility in people with motor complete SCI. Involuntary muscle activity attributed to spasticity, however, can prevent such individuals from using an exoskeleton. Specifically, although most exoskeleton technologies can accommodate low to moderate spasticity, the presence of moderate to severe spasticity can significantly impair gait kinematics when using an exoskeleton...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29909465/anteromedial-femoral-neck-plate-with-cannulated-screws-for-the-treatment-of-irreducible-displaced-femoral-neck-fracture-in-young-patients-a-preliminary-study
#18
Linbo Zhuang, Lisheng Wang, Dongming Xu, Zhiyong Wang
BACKGROUNDS: Although most displaced femoral neck fractures of young patients can be repositioned successfully by closed reduction, there are still some can not repositioned successfully by this way and open reductions are required. This type of fracture was defined as irreducible displaced femoral neck fracture in this study. The purpose of this study was to introduce a new technique using anteromedial femoral neck plate with cannulated screws fixation by open reduction for the treatment of irreducible displaced femoral neck fractures in young patients...
June 16, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29908218/technique-for-docking-and-port-placement-using-a-purpose-built-robotic-system-sp1098-in-human-cadaver
#19
Juan D Garisto, Riccardo Bertolo, Jihad Kaouk
OBJECTIVES: To describe step-by-step the port placement and the robot docking of the new purpose-built robotic platform for R-LESS. The feasibility of different approaches to the pelvic fossa and the retroperitoneum was reported in cadaver models. METHODS: This was a preclinical study on human cadavers to assess the feasibility of the da Vinci SP1098 surgical system for R-LESS pelvic fossa and retroperitoneal urological surgeries. We used the SP1098 to perform R-LESS prostatectomies and cysto-prostatectomies with transperineal and transvesical approaches, and nephrectomies (radical or partial) with retroperitoneal approach...
June 13, 2018: Urology
https://www.readbyqxmd.com/read/29907547/interrupted-versus-continuous-suturing-for-vesicourethral-anastomosis-during-radical-prostatectomy-a-systematic-review-and-meta-analysis
#20
REVIEW
Karl F Kowalewski, Christian Tapking, Svetlana Hetjens, Felix Nickel, Philipp Mandel, Philipp Nuhn, Manuel Ritter, Judd W Moul, Joachim W Thüroff, Maximilian C Kriegmair
CONTEXT: Vesicourethral anastomosis (VUA) is a crucial step during radical prostatectomy (RP). Generally, either a continuous (CS) or an interrupted suture (IS) is used. However, there is no clear evidence if one technique is superior to the other. OBJECTIVE: This study aimed to provide a systematic overview and comparison between IS and CS for the VUA during RP. EVIDENCE ACQUISITION: The study was conducting according to the PRISMA guidelines...
June 12, 2018: European Urology Focus
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