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https://www.readbyqxmd.com/read/29029068/considering-health-equity-when-moving-from-evidence-based-guideline-recommendations-to-implementation-a-case-study-from-an-upper-middle-income-country-on-the-grade-approach
#1
Javier Eslava-Schmalbach, Paola Mosquera, Juan Pablo Alzate, Kevin Pottie, Vivian Welch, Elie A Akl, Janet Jull, Eddy Lang, Srinivasa Vittal Katikireddi, Rachel Morton, Lehana Thabane, Bev Shea, Airton T Stein, Jasvinder Singh, Ivan D Florez, Gordon Guyatt, Holger Schünemann, Peter Tugwell
The availability of evidence-based guidelines does not ensure their implementation and use in clinical practice or policy making. Inequities in health have been defined as those inequalities within or between populations that are avoidable, unnecessary and also unjust and unfair. Evidence-based clinical practice and public health guidelines ('guidelines') can be used to target health inequities experienced by disadvantaged populations, although guidelines may unintentionally increase health inequities. For this reason, there is a need for evidence-based clinical practice and public health guidelines to intentionally target health inequities experienced by disadvantaged populations...
October 3, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29028861/the-rationale-of-anti-aging-cosmetic-ingredients
#2
Michele Verschoore, Marion Nielson
<p>Anti-aging cosmetics are a mainstay in the skin care regimen irrespective of gender or human ethnics. Skin aging involves functional slowdown combined with environmental induced alterations. This paper focuses on cosmetic ingredients that aim at alleviating the signs of skin aging, with proven/controlled results of efficacy. Anti-aging skin care widely benefits from new ingredients and modern evaluation methods that can substantiate the effects of innovative products in a perceivable and sensitive manner...
June 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29026904/one-step-functionalization-of-magnetic-nanoparticles-with-4-mercaptophenylboronic-acid-for-a-highly-efficient-analysis-of-n-glycopeptides
#3
Jizong Yao, Jiawen Wang, Nianrong Sun, Chunhui Deng
A very simple and amazing approach was proposed to synthesize MPBA functionalized magnetic nanoparticles via the interaction between Fe and SH, and the as-prepared nanoparticles were successfully applied for the efficient analysis of glycopeptides in complex bio-samples with sensitivity and selectivity.
October 13, 2017: Nanoscale
https://www.readbyqxmd.com/read/29025218/regenerative-cells-for-facial-surgery-biofilling-and-biocontouring
#4
Steven R Cohen, Sierra Hewett, Lauren Ross, Flore Delaunay, Ashley Goodacre, Char Ramos, Tracy Leong, Ahmad Saad
Zuk et al in 2001 identified stem and regenerative cells within the stromal vascular fraction of fat. In preclinical studies, these cells appeared to stimulate angiogenesis and reduce inflammation, and soon thereafter, clinical use of stromal vascular fraction (SVF) evolved as researchers such as Rigotti, Coleman, Mojallal, our group, and others demonstrated that fat can be used for both therapeutic and aesthetic indications. The regenerative effects of fat and its contents on facial aesthetics have been shown at the histologic and cellular level...
July 1, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29024897/a-framework-for-engaging-stakeholders-on-the-management-of-alien-species
#5
Ana Novoa, Ross Shackleton, Susan Canavan, Cathleen Cybèle, Sarah J Davies, Katharina Dehnen-Schmutz, Jana Fried, Mirijam Gaertner, Sjirk Geerts, Charles L Griffiths, Haylee Kaplan, Sabrina Kumschick, David C Le Maitre, G John Measey, Ana L Nunes, David M Richardson, Tamara B Robinson, Julia Touza, John R U Wilson
Alien species can have major ecological and socioeconomic impacts in their novel ranges and so effective management actions are needed. However, management can be contentious and create conflicts, especially when stakeholders who benefit from alien species are different from those who incur costs. Such conflicts of interests mean that management strategies can often not be implemented. There is, therefore, increasing interest in engaging stakeholders affected by alien species or by their management. Through a facilitated workshop and consultation process including academics and managers working on a variety of organisms and in different areas (urban and rural) and ecosystems (terrestrial and aquatic), we developed a framework for engaging stakeholders in the management of alien species...
October 9, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29024789/in-vitro-pharmacological-characterization-of-the-bispyridinium-non-oxime-compound-mb327-and-its-2-and-3-regioisomers
#6
K V Niessen, T Seeger, S Rappenglück, T Wein, G Höfner, K T Wanner, H Thiermann, F Worek
The primary toxic mechanism of organophosphorus compounds, i.e. nerve agents or pesticides, is based on the irreversible inhibition of acetylcholinesterase. In consequence of the impaired hydrolysis, the neurotransmitter acetylcholine accumulates in cholinergic synapses and disturbs functional activity of nicotinic and muscarinic acetylcholine receptors by overstimulation and subsequent desensitization. The resulting cholinergic syndrome will become acute life-threatening, if not treated adequately. The current standard treatment, consisting of administration of a competitive mAChR antagonist (e...
October 9, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/29023332/should-t-tube-drainage-be-performed-for-choledocholithiasis-after-laparoscopic-common-bile-duct-exploration-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#7
Woods Zhang, Ge Li, Yan-Ling Chen
BACKGROUND: Laparoscopic common bile duct exploration (LCBDE) has been verified to be a comparatively effective treatment approach for uncomplicated choledocholithiasis, and it has been previously proposed that the primary duct closure (PDC) technique, in which the bile duct can directly be sutured in only 1 step compared with the T-tube drainage (TTD), can be deemed a choice after LCBDE; however, the conventional TTD performance is controversial in the minimally invasive surgery era...
October 11, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/29021141/use-of-a-dynamic-gait-trainer-for-a-child-with-thoracic-level-spinal-cord-injury
#8
Wendy Altizer, Garey Noritz, Ginny Paleg
Paediatric spinal cord injury (SCI) can result in permanent mobility impairment with consequences for activity, participation and quality of life. This case documents the effect of an overground supported stepping intervention using a dynamic gait trainer. To our knowledge, there are no published studies on this intervention for children with SCI and similar interventions have only been reported in children at American Spinal Injury Association Impairment Scale (AIS) levels B and C.A child with a T10 (thoracic level, vertebra 10), AIS level A injury, sustained at 2 years of age, continued to make gains in all areas including participation, activity, body structure and function over the following 4 years...
October 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29019688/yb-otf-3-catalyzed-desymmetrization-of-myo-inositol-1-3-5-orthoformate-and-its-application-in-the-synthesis-of-chiral-inositol-phosphates
#9
Laxmansingh T Padiyar, Medel Manuel L Zulueta, Narayana Murthy Sabbavarapu, Shang-Cheng Hung
A variety of inositol phosphates including myo-inositol-1,4,5-trisphosphate, which is a secondary messenger in transmembrane signaling, were selectively synthesized via Yb(OTf)3-catalyzed desymmetrization of myo-inositol-1,3,5-orthoformate using a proline-based chiral anhydride as an acylation precursor. The investigated catalytic system could regioselectively differentiate the enantiotopic hydroxy groups of myo-inositol-1,3,5-orthoformate in the presence of a chiral auxiliary. This key step to generate a suitably protected chiral myo-inositol derivatives is described here as a unified approach to access inositol phosphates...
October 11, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29019317/precept-an-evidence-assessment-framework-for-infectious-disease-epidemiology-prevention-and-control
#10
Thomas Harder, Anja Takla, Tim Eckmanns, Simon Ellis, Frode Forland, Roberta James, Joerg J Meerpohl, Antony Morgan, Eva Rehfuess, Holger Schünemann, Teun Zuiderent-Jerak, Helena de Carvalho Gomes, Ole Wichmann
Decisions in public health should be based on the best available evidence, reviewed and appraised using a rigorous and transparent methodology. The Project on a Framework for Rating Evidence in Public Health (PRECEPT) defined a methodology for evaluating and grading evidence in infectious disease epidemiology, prevention and control that takes different domains and question types into consideration. The methodology rates evidence in four domains: disease burden, risk factors, diagnostics and intervention. The framework guiding it has four steps going from overarching questions to an evidence statement...
October 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29018836/one-step-fabrication-of-bone-morphogenetic-protein-2-gene-activated-porous-poly-l-lactide-scaffold-for-bone-induction
#11
Jingwen Xue, Hang Lin, Allison Bean, Ying Tang, Jian Tan, Rocky S Tuan, Bing Wang
Bone morphogenetic protein 2 (BMP2) is an efficacious inducer for the osteogenesis of mesenchymal stem cells (MSCs). Conventional applications of BMP2 have involved either the direct incorporation of BMP2 protein or ex vivo BMP2 gene transfer into stem cells prior to their transplantation. These approaches are able to promote bone formation to some extent; however, they are hampered by either the lack of stability and sustainability of BMP2 protein or the time-consuming and cost-prohibitive in vitro cell culture procedure...
December 15, 2017: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/28993884/responsiveness-of-the-euroqol-5-dimension-eq-5d-in-adolescent-idiopathic-scoliosis
#12
Prudence Wing Hang Cheung, Carlos King Ho Wong, Sin Ting Lau, Jason Pui Yin Cheung
PURPOSE: To test the responsiveness of the EuroQoL 5-dimension (EQ-5D) utility scores for adolescent idiopathic scoliosis (AIS). METHODS: A baseline sample of 227 AIS patients was recruited between August and October 2015, and was surveyed prospectively to 9-12 months follow-up. EQ-5D-5L utility scores were derived using a two-step approach: (1) cross-walking from five-level responses to three-level responses and (2) applying the EQ-5D-3L Chinese population value set...
October 9, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28989686/electrochemical-maps-and-movies-of-the-hydrogen-evolution-reaction-on-natural-crystals-of-molybdenite-mos2-basal-vs-edge-plane-activity
#13
Cameron L Bentley, Minkyung Kang, Faduma M Maddar, Fengwang Li, Marc Walker, Jie Zhang, Patrick R Unwin
Two dimensional (2D) semiconductor materials, such as molybdenum disulfide (MoS2) have attracted considerable interest in a range of chemical and electrochemical applications, for example, as an abundant and low-cost alternative electrocatalyst to platinum for the hydrogen evolution reaction (HER). While it has been proposed that the edge plane of MoS2 possesses high catalytic activity for the HER relative to the "catalytically inert" basal plane, this conclusion has been drawn mainly from macroscale electrochemical (voltammetric) measurements, which reflect the "average" electrocatalytic behavior of complex electrode ensembles...
September 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28987609/structure-based-design-and-synthesis-of-2-4-diaminopyrimidines-as-egfr-l858r-t790m-selective-inhibitors-for-nsclc
#14
Lingfeng Chen, Weitao Fu, Chen Feng, Rong Qu, Linjiang Tong, Lulu Zheng, Bo Fang, Yinda Qiu, Jie Hu, Yuepiao Cai, Jianpeng Feng, Hua Xie, Jian Ding, Zhiguo Liu, Guang Liang
Mutated epidermal growth factor receptor (EGFR) is a major driver of non-small cell lung cancer (NSCLC). The EGFR(T790M) secondary mutation has become a leading cause of clinically-acquired resistance to gefitinib and erlotinib. Herein, we present a structure-based design approach to increase the potency and selectivity of the previously reported reversible EGFR inhibitor 7, at the kinase and cellular levels. Three-step structure-activity relationship exploration led to promising compounds 19e and 19h with unique chemical structure and binding mode from the other third-generation tyrosine kinase inhibitors...
September 20, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28985904/facile-preparation-of-multi-functionalized-hybrid-monoliths-via-two-step-photo-initiated-reactions-for-two-dimensional-liquid-chromatography-mass-spectrometry
#15
Haiyang Zhang, Shujuan Ma, Yating Yao, Yanan Li, Ya Li, Junjie Ou, Mingliang Ye, Yinmao Wei
A facile approach was developed to prepare hybrid monoliths with different functions via two-step photo-initiated reactions. Firstly, acrylopropyl polyhedral oligomertic silsesquioxane (acryl-POSS) and propargyl acrylate (PA) were used as precursors to synthesize alkynyl-functionalized hybrid monoliths via photo-initiated free radical polymerization. Secondly, the hybrid monoliths were modified with 1-octadecanethiol (ODT) and sodium 3-mercapto-1-propanesulfonate (SMPS) via photo-initiated thiol-yne click reaction to prepare reversed-phase (RP) and strong cation-exchange (SCX) hybrid monoliths, respectively...
September 28, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28982088/multi-step-approach-to-add-value-to-corncob-production-of-biomass-degrading-enzymes-lignin-and-fermentable-sugars
#16
Michele Michelin, Héctor A Ruiz, Maria de Lourdes T M Polizeli, José A Teixeira
This work presents an integrated and multi-step approach for the recovery and/or application of the lignocellulosic fractions from corncob in the production of high value added compounds as xylo-oligosaccharides, enzymes, fermentable sugars, and lignin in terms of biorefinery concept. For that, liquid hot water followed by enzymatic hydrolysis were used. Liquid hot water was performed using different residence times (10-50min) and holding temperature (180-200°C), corresponding to severities (log(R0)) of 3...
September 20, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28981379/a-pilot-randomized-controlled-trial-of-a-computer-delivered-brief-intervention-for-substance-use-and-risky-sex-during-pregnancy
#17
Golfo Tzilos Wernette, Melissa Plegue, Christopher W Kahler, Ananda Sen, Caron Zlotnick
BACKGROUND: Sexually transmitted infections (STIs) are an increasingly critical and costly health problem for American childbearing women. Pregnant women who misuse substances are more likely to engage in risky sexual behavior that leads to STIs. Substance use and risky sex during pregnancy are both associated with numerous negative consequences for the woman and the developing fetus. STUDY DESIGN: A two-group, randomized controlled trial. PARTICIPANTS: Recruitment of 50 pregnant women (30% Latina; 24...
October 5, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28978499/developing-social-media-based-suicide-prevention-messages-in-partnership-with-young-people-exploratory-study
#18
Jo Robinson, Eleanor Bailey, Sarah Hetrick, Steve Paix, Matt O'Donnell, Georgina Cox, Maria Ftanou, Jaelea Skehan
BACKGROUND: Social media is increasingly being used by young people for health-related issues, including communicating about suicide. Due to the concerns about causing distress or inducing suicidal thoughts or behaviors, to date young people neither have been engaged in the development of social media-based suicide prevention interventions nor have interventions focused on educating young people about safe ways to communicate about suicide online. Given the potential that social media holds to deliver messages to vast numbers of people across space and time and the fact that young people often prefer to seek help from their friends and peers, safely educating and engaging young people to develop suicide prevention messages that can be delivered via social media is an obvious next step...
October 4, 2017: JMIR Mental Health
https://www.readbyqxmd.com/read/28978498/a-mobile-phone-based-life-skills-training-program-for-substance-use-prevention-among-adolescents-pre-post-study-on-the-acceptance-and-potential-effectiveness-of-the-program-ready4life
#19
Severin Haug, Raquel Paz Castro, Christian Meyer, Andreas Filler, Tobias Kowatsch, Michael P Schaub
BACKGROUND: Substance use and misuse often first emerge during adolescence. Generic life skills training that is typically conducted within the school curriculum is effective at preventing the onset and escalation of substance use among adolescents. However, the dissemination of such programs is impeded by their large resource requirements in terms of personnel, money, and time. Life skills training provided via mobile phones might be a more economic and scalable approach, which additionally matches the lifestyle and communication habits of adolescents...
October 4, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28974346/retrospective-analysis-of-the-akin-osteotomy
#20
Steven M Douthett, Nathan K Plaskey, Lawrence M Fallat, John Kish
Hallux abductovalgus is one of the most common deformities addressed by foot and ankle surgeons. Surgically, it can be approached using a wide variety of procedures. After performing the first metatarsal osteotomy, the final step is often to realign the great toe in a rectus position. This is performed with an osteotomy of the proximal phalanx. The Akin osteotomy is a medially based closing wedge osteotomy of the proximal phalanx. When executing the osteotomy, the goal is not only to correct abduction, but also to keep the lateral cortex intact, which allows it to act as an additional point of fixation...
September 30, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
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