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https://www.readbyqxmd.com/read/27906298/high-resolution-brillouin-optical-correlation-domain-analysis-with-no-spectral-scanning
#1
Eyal Preter, Dexin Ba, Yosef London, Orel Shlomi, Yair Antman, Avi Zadok
Distributed Brillouin fiber sensors typically rely on the reconstruction of the steady-state Brillouin gain spectrum (BGS), through spectral scanning of the frequency offset between the pump and signal waves. In this work, we propose and demonstrate an alternative approach, in which the local Brillouin frequency shift (BFS) is extracted from temporal transient analysis of the step response of the amplified signal wave. Measurements are taken at only two arbitrary frequency offsets between pump and signal. No spectral scanning and no prior knowledge of a reference BGS are necessary...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27902621/total-laparoscopic-right-hemicolectomy-with-3-step-stapled-intracorporeal-isoperistaltic-ileocolic-anastomosis-for-colon-cancer-an-evaluation-of-short-term-outcomes
#2
Tu Jian-Cheng, Wang Shu-Sheng, Zhang Bo, Fang Jian, Zhou Liang
Laparoscopic right hemicolectomy with extracorporeal anastomosis is a widely used procedure; several authors have published their approach to intracorporeal anastomosis. In this paper, we present an approach developed by us and compare short-term outcomes with those of extracorporeal anastomosis in colon cancer patients.Retrospective review of colon cancer patients treated with laparoscopic right hemicolectomy either with intracorporeal anastomosis (TLG group) or extracorporeal anastomosis (LG group) at the Zhangjiagang Hospital Affiliated to Soochow University between January 2011 and October 2015...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27901019/additives-for-vaccine-storage-to-improve-thermal-stability-of-adenoviruses-from-hours-to-months
#3
Maria Pelliccia, Patrizia Andreozzi, Jayson Paulose, Marco D'Alicarnasso, Valeria Cagno, Manuela Donalisio, Andrea Civra, Rebecca M Broeckel, Nicole Haese, Paulo Jacob Silva, Randy P Carney, Varpu Marjomäki, Daniel N Streblow, David Lembo, Francesco Stellacci, Vincenzo Vitelli, Silke Krol
Up to 80% of the cost of vaccination programmes is due to the cold chain problem (that is, keeping vaccines cold). Inexpensive, biocompatible additives to slow down the degradation of virus particles would address the problem. Here we propose and characterize additives that, already at very low concentrations, improve the storage time of adenovirus type 5. Anionic gold nanoparticles (10(-8)-10(-6) M) or polyethylene glycol (PEG, molecular weight ∼8,000 Da, 10(-7)-10(-4) M) increase the half-life of a green fluorescent protein expressing adenovirus from ∼48 h to 21 days at 37 °C (from 7 to >30 days at room temperature)...
November 30, 2016: Nature Communications
https://www.readbyqxmd.com/read/27898889/accuracies-of-genomic-prediction-of-feed-efficiency-traits-using-different-prediction-and-validation-methods-in-an-experimental-nelore-cattle-population
#4
R M O Silva, B O Fragomeni, D A L Lourenco, A F B Magalhães, N Irano, R Carvalheiro, R C Canesin, M E Z Mercadante, A A Boligon, F S Baldi, I Misztal, L G Albuquerque
Animal feeding is the most important economic component of beef production systems. Selection for feed efficiency has not been effective mainly due to difficult and high costs to obtain the phenotypes. The application of genomic selection using SNP can decrease the cost of animal evaluation as well as the generation interval. The objective of this study was to compare methods for genomic evaluation of feed efficiency traits using different cross-validation layouts in an experimental beef cattle population genotyped for a high-density SNP panel (BovineHD BeadChip assay 700k, Illumina Inc...
September 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27898882/genome-scan-for-postmortem-carcass-traits-in-nellore-cattle
#5
G A Fernandes Júnior, R B Costa, G M F de Camargo, R Carvalheiro, G J M Rosa, F Baldi, D A Garcia, D G M Gordo, R Espigolan, L Takada, A F B Magalhães, T Bresolin, F L B Feitosa, L A L Chardulo, H N de Oliveira, L G de Albuquerque
Carcass traits measured after slaughter are economically relevant traits in beef cattle. In general, the slaughter house payment system is based on HCW. Ribeye area (REA) is associated with the amount of the meat in the carcass, and a minimum of backfat thickness (BFT) is necessary to protect the carcass during cooling. The aim of this study was to identify potential genomic regions harboring candidate genes affecting those traits in Nellore cattle. The data set used in the present study consisted of 1,756 Nellore males with phenotype records...
October 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27896982/predictive-modeling-of-hospital-readmission-rates-using-electronic-medical-record-wide-machine-learning-a-case-study-using-mount-sinai-heart-failure-cohort
#6
Khader Shameer, Kipp W Johnson, Alexandre Yahi, Riccardo Miotto, L I Li, Doran Ricks, Jebakumar Jebakaran, Patricia Kovatch, Partho P Sengupta, Sengupta Gelijns, Alan Moskovitz, Bruce Darrow, David L David, Andrew Kasarskis, Nicholas P Tatonetti, Sean Pinney, Joel T Dudley
Reduction of preventable hospital readmissions that result from chronic or acute conditions like stroke, heart failure, myocardial infarction and pneumonia remains a significant challenge for improving the outcomes and decreasing the cost of healthcare delivery in the United States. Patient readmission rates are relatively high for conditions like heart failure (HF) despite the implementation of high-quality healthcare delivery operation guidelines created by regulatory authorities. Multiple predictive models are currently available to evaluate potential 30-day readmission rates of patients...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27896797/a-telephone-based-intervention-to-promote-physical-activity-during-smoking-cessation-a-randomized-controlled-proof-of-concept-study
#7
Uma S Nair, Freda Patterson, Daniel Rodriguez, Bradley N Collins
Smoking and physical inactivity contribute to disproportionate disease burden among underserved adults. Telephone-based interventions (quitlines) are becoming the standard care for addressing smoking. There is increasing interest to determine whether quitlines can be utilized to administer interventions for other unhealthy behaviors. This study aims to examine the proof-of-concept and potential efficacy of a telephone-based behavioral counseling intervention to boost daily low-to-moderate physical activity among low-income, physically inactive smokers...
November 28, 2016: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/27896655/transhepatic-hilar-approach-for-perihilar-cholangiocarcinoma-significance-of-early-judgment-of-resectability-and-safe-vascular-reconstruction
#8
Naohisa Kuriyama, Shuji Isaji, Akihiro Tanemura, Yusuke Iizawa, Hiroyuki Kato, Yasuhiro Murata, Yoshinori Azumi, Masashi Kishiwada, Shugo Mizuno, Masanobu Usui, Hiroyuki Sakurai
In the most common surgical procedure for perihilar cholangiocarcinoma, the margin status of the proximal bile duct is determined at the final step. Our procedure, the transhepatic hilar approach, confirms a cancer-negative margin status of the proximal bile duct first. We first performed a partial hepatic parenchymal transection to expose the hilar plate, and then transected the proximal bile duct to confirm margin status. Then, divisions of the hepatic artery and portal vein of the future resected liver are performed, followed by the residual hepatic parenchymal transection...
November 28, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27895917/validation-of-biomarkers-to-predict-response-to-immunotherapy-in-cancer-volume-i-pre-analytical-and-analytical-validation
#9
REVIEW
Giuseppe V Masucci, Alessandra Cesano, Rachael Hawtin, Sylvia Janetzki, Jenny Zhang, Ilan Kirsch, Kevin K Dobbin, John Alvarez, Paul B Robbins, Senthamil R Selvan, Howard Z Streicher, Lisa H Butterfield, Magdalena Thurin
Immunotherapies have emerged as one of the most promising approaches to treat patients with cancer. Recently, there have been many clinical successes using checkpoint receptor blockade, including T cell inhibitory receptors such as cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death-1 (PD-1). Despite demonstrated successes in a variety of malignancies, responses only typically occur in a minority of patients in any given histology. Additionally, treatment is associated with inflammatory toxicity and high cost...
2016: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/27893045/association-of-3-different-antihypertensive-medications-with-hip-and-pelvic-fracture-risk-in-older-adults-secondary-analysis-of-a-randomized-clinical-trial
#10
Rachel Puttnam, Barry R Davis, Sara L Pressel, Paul K Whelton, William C Cushman, Gail T Louis, Karen L Margolis, Suzanne Oparil, Jeffrey Williamson, Alokananda Ghosh, Paula T Einhorn, Joshua I Barzilay
Importance: On the basis of observational studies, the use of thiazide diuretics for the treatment of hypertension is associated with reduced fracture risk compared with nonuse. Data from randomized clinical trials are lacking. Objective: To examine whether the use of thiazide diuretics for the treatment of hypertension is associated with reduced fracture risk compared with nonuse. Design, Setting, and Participants: Using Veterans Affairs and Medicare claims data, this study examined hip and pelvic fracture hospitalizations in Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial participants randomized to first-step therapy with a thiazide-type diuretic (chlorthalidone), a calcium channel blocker (amlodipine besylate), or an angiotensin-converting enzyme inhibitor (lisinopril)...
November 21, 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27892422/prognostic-value-of-serial-six-minute-walk-tests-using-tele-accelerometry-in-patients-with-chronic-heart-failure-a-pre-specified-sub-study-of-the-tim-hf-trial
#11
Sandra Prescher, Christoph Schoebel, Kerstin Koehler, Oliver Deckwart, Brunhilde Wellge, Marcus Honold, Oliver Hartmann, Sebastian Winkler, Friedrich Koehler
BACKGROUND: The six-minute walk test (6MWT) is an established functional test assessing exercise capacity and is used to predict clinical prognosis in patients with chronic heart failure (HF). Tele-accelerometry is a novel approach to activity monitoring using telemedical data transfer and allows a Tele-6MWT to be performed in an outpatient setting. It offers patients the option of performing simple serial follow-up tests in their own home. AIMS: The aim of this study was to investigate the prognostic value of serial Tele-6MWTs using tele-accelerometry in patients with HF...
October 2016: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/27891544/an-in-vitro-digestion-method-adapted-for-carotenoids-and-carotenoid-esters-moving-forward-towards-standardization
#12
Daniele Bobrowski Rodrigues, Lilian Regina Barros Mariutti, Adriana Zerlotti Mercadante
In vitro digestion methods are a useful approach to predict the bioaccessibility of food components and overcome some limitations or disadvantages associated with in vivo methodologies. Recently, the INFOGEST network published a static method of in vitro digestion with a proposal for assay standardization. The INFOGEST method is not specific for any food component; therefore, we aimed to adapt this method to assess the in vitro bioaccessibility of carotenoids and carotenoid esters in a model fruit (Byrsonima crassifolia)...
November 28, 2016: Food & Function
https://www.readbyqxmd.com/read/27889436/wide-variation-found-in-care-of-opioid-exposed-newborns
#13
Debra L Bogen, Bonny L Whalen, Laura R Kair, Mark Vining, Beth A King
OBJECTIVE: Standardized practices for the management of neonatal abstinence syndrome (NAS) are associated with shorter lengths of stay, but optimal protocols are not established. We sought to identify practice variations for newborns with in utero chronic opioid exposure among hospitals in the Better Outcomes Through Research for Newborns (BORN) network. METHODS: Nursery site leaders completed a survey about hospitals' policies and practices regarding care for infants with chronic opioid exposure (≥3 weeks)...
November 23, 2016: Academic Pediatrics
https://www.readbyqxmd.com/read/27888405/characterization-of-b-h-agostic-compounds-involved-in-the-dehydrogenation-of-amine-boranes-by-group-4-metallocenes
#14
Jingwen Zhu, Emilie-Laure Zins, Mohammad Esmaïl Alikhani
For over a decade, amine-borane has been considered as a potential chemical hydrogen vector in the context of a search for cleaner energy sources. When catalyzed by organometallic complexes, the reaction mechanisms currently considered involve the formation of β-BH agostic intermediates. A thorough understanding of these intermediates may constitute a crucial step toward the identification of ideal catalysts. Topological approaches such as QTAIM and ELF revealed to be particularly suitable for the description of β-agostic interactions...
December 2016: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/27888402/infectious-encephalitis-utility-of-a-rational-approach-to-aetiological-diagnosis-in-daily-clinical-practice
#15
C López-Sánchez, E Sulleiro, C Bocanegra, S Romero, G Codina, I Sanz, J Esperalba, J Serra, C Pigrau, J Burgos, B Almirante, V Falcó
In this study we attempt to assess the utility of a simplified step-wise diagnostic algorithm to determinate the aetiology of encephalitis in daily clinical practice and to describe the main causes in our setting. This was a prospective cohort study of all consecutive cases of encephalitis in adult patients diagnosed between January 2010 and March 2015 at the University Hospital Vall d'Hebron in Barcelona, Spain. The aetiological study was carried out following the proposed step-wise algorithm. The proportion of aetiological diagnoses achieved in each step was analysed...
November 25, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27887914/practical-and-functional-classification-of-the-double-urethra-a-variable-complex-and-fascinating-malformation-observed-in-20-patients
#16
M Lima, F Destro, M Maffi, D Persichetti Proietti, G Ruggeri
INTRODUCTION: Urethral duplication is a rare and variable malformation of the urinary tract, with non-univocal and complex management. In addition, different classification schemes have been proposed, but none have considered all the possible variants. OBJECTIVE: To report experience with the management of 20 urethral duplication patients and propose a classification of this anomaly. MATERIALS AND METHODS: A retrospective analysis collecting information regarding 20 patients (Table) with urethral duplication treated at a single institution over the past 40 years...
November 3, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27887818/three-dimensional-morphology-of-the-left-ventricular-outflow-tract-impact-on-grading-aortic-stenosis-severity
#17
Luis Caballero, Daniel Saura, María José Oliva-Sandoval, Josefa González-Carrillo, María Dolores Espinosa, Miguel García-Navarro, Mariano Valdés, Patrizio Lancellotti, Gonzalo de la Morena
BACKGROUND: Left ventricular outflow tract (LVOT) measurement is a critical step in the quantification of aortic valve area. The assumption of a circular morphology of the LVOT may induce some errors. The aim of this study was to assess the three-dimensional (3D) morphology of the LVOT and its impact on grading aortic stenosis severity. METHODS: Fifty-eight patients with aortic stenosis were studied retrospectively. LVOT dimensions were measured using 3D transesophageal echocardiography at three levels: at the hinge points (HP) of the aortic valve and at 4 and 8 mm proximal to the annular plane...
November 22, 2016: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/27887620/anatomy-meets-dentistry-linking-anatomy-and-clinical-practice-in-the-preclinical-dental-curriculum
#18
Nicole Rafai, Martin Lemos, Lieven Nils Kennes, Ayichah Hawari, Susanne Gerhardt-Szép, Irmgard Classen-Linke
BACKGROUND: Establishing a strong link early on between preclinical coursework and the clinical context is necessary for students to be able to recognize the practical relevance of the curriculum during their preclinical anatomical courses and to transfer knowledge more easily. Our objective was to enhance the clinical relevance of a preclinical anatomy course for second-year medical students of dentistry by implementing an interdisciplinary skills training course on "Palpation of the Head and Neck Muscles" and to measure the learning outcomes...
November 25, 2016: BMC Medical Education
https://www.readbyqxmd.com/read/27885386/wrist-denervation-of-the-posterior-interosseous-nerve-through-a-volar-approach-a-new-technique-with-anatomical-considerations
#19
Stephan Grechenig, Surjit Lidder, Manuel Dreu, Claudia Dolcet, Lucy Marguerite Cooper, Georg Feigl
PURPOSE: Full or selective wrist denervation is an effective treatment for chronic wrist pain. In this cadaveric study, a volar approach for prophylactic denervation of the posterior interosseous nerve (PIN) and the anterior interosseous nerve (AIN) was assessed, which can simultaneously be performed during volar approaches for distal radius fracture fixation or in combination with metalwork removal. MATERIALS AND METHODS: In total 40 adult upper limbs, embalmed using Thiel's method, were investigated...
November 24, 2016: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/27882272/the-impact-of-wearable-device-enabled-health-initiative-on-physical-activity-and-sleep
#20
Olga Crowley, Laura Pugliese, Stan Kachnowski
OBJECTIVES: The Personal Health Management Study (PHMS) is an assessment of the effect of a voluntary employee-facing health initiative using a commercially-available wearable device implemented among 565 employees of Boehringer Ingelheim Pharmaceuticals, Inc. The results of the initiative on physical activity (measured as steps) and sleep is reported. METHODS: This was a 12-month, prospective, single-cohort intervention study using a wearable activity-measuring device tracking steps and sleep (entire study period) and a system of health-promoting incentives (first nine months of study period)...
October 11, 2016: Curēus
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