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https://www.readbyqxmd.com/read/28333045/the-manureecomine-pilot-installation-advanced-integration-of-technologies-for-the-management-of-organics-and-nutrients-in-livestock-waste
#1
Cristina Pintucci, Marta Carballa, Sam Varga, Jimena Sarli, Lai Peng, Johannes Bousek, Chiara Pedizzi, Maël Ruscalleda, Elena Tarragó, Delphine Prat, Giovanni Colica, Merijn Picavet, Joop Colsen, Oscar Benito, Marilos Balaguer, Sebastià Puig, Juan M Lema, Jesús Colprim, Werner Fuchs, Siegfried E Vlaeminck
Manure represents an exquisite mining opportunity for nutrient recovery (nitrogen and phosphorus), and for their reuse as renewable fertilisers. The ManureEcoMine proposes an integrated approach of technologies, operated in a pilot-scale installation treating swine manure (83.7%) and Ecofrit(®) (16.3%), a mix of vegetable residues. Thermophilic anaerobic digestion was performed for 150 days, the final organic loading rate was 4.6 kgCOD m(-3) d(-1), with a biogas production rate of 1.4 Nm(3) m(-3) d(-1). The digester was coupled to an ammonia side-stream stripping column and a scrubbing unit for free ammonia inhibition reduction in the digester, and nitrogen recovery as ammonium sulphate...
March 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28332743/nitrene-radical-approach-to-saturated-heterocycles-cobalt-porphyrin-catalysed-intramolecular-ring-closing-c-h-amination-of-aliphatic-azides
#2
Bas de Bruin, Petrus F Kuijpers, Martijn J Tiekink, Willem B Breukelaar, Daniël L J Broere, Nicolaas P van Leest, Jarl Ivar van der Vlugt, Joost N H Reek
Cobalt porphyrin catalysed intramolecular ring-closing C-H bond amination enables direct synthesis of various N-heterocycles from aliphatic azides. Pyrrolidines, oxazolidines imidazolidines, isoindolines and tetrahydroisoquinoline can be obtained in good to excellent yields in a single reaction step with an air and moisture stable catalyst. Kinetic studies of the reaction in combination with DFT calculations reveal a metallo-radical-type mechanism involving rate limiting azide activation to form the key cobalt(III)-nitrene radical intermediate...
March 23, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28331537/combined-totally-mini-invasive-approach-in-necrotizing-pancreatitis-a-case-report-and-systematic-literature-review
#3
REVIEW
Luca Sorrentino, Osvaldo Chiara, Massimiliano Mutignani, Fabrizio Sammartano, Paolo Brioschi, Stefania Cimbanassi
BACKGROUND: Currently, both the step-up approach, combining percutaneous drainage (PD) and video-assisted retroperitoneal debridement (VARD), and endoscopic transgastric necrosectomy (ETN) are mini-invasive techniques for infected necrosis in severe acute pancreatitis. A combination of these approaches could maximize the management of necrotizing pancreatitis, conjugating the benefits from both the experiences. However, reporting of this combined strategy is anecdotal. This is the first reported case of severe necrotizing pancreatitis complicated by biliary fistula treated by a combination of ETN, PD, VARD, and endoscopic biliary stenting...
2017: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/28326791/enantioselective-synthesis-of-dilignol-model-compounds-and-their-stereodiscrimination-study-with-a-dye-decolorizing-peroxidase
#4
Gaochao Huang, Ruben Shrestha, Kaimin Jia, Brian V Geisbrecht, Ping Li
A four-step enantioselective approach was developed to synthesize anti (1R,2S)-1a and (1S,2R)-1b containing a β-O-4 linkage in good yields. A significant difference was observed for the apparent binding affinities of four stereospecific lignin model compounds with TcDyP by surface plasmon resonance, which was not translated into a significant difference in enzyme activities. The discrepancy may be attributed to the conformational change involving a loop widely present in DyPs upon H2O2 binding.
March 22, 2017: Organic Letters
https://www.readbyqxmd.com/read/28322552/one-step-fabrication-of-a-microfluidic-device-with-an-integrated-membrane-and-embedded-reagents-by-multimaterial-3d-printing
#5
Feng Li, Petr Smejkal, Niall P Macdonald, Rosanne M Guijt, Michael C Breadmore
One of the largest impediments in the development of microfluidic-based smart sensing systems is the manufacturability of integrated, complex devices. Here, we propose multimaterial 3D printing for the fabrication of such devices in a single step. A microfluidic device containing an integrated porous membrane and embedded liquid reagents was made by 3D printing and applied for the analysis of nitrate from soil. The manufacture of the integrated, sealed device was realised as a single print within 30 min. The body of the device was printed in transparent acrylonitrile butadiene styrene (ABS), and contained a 400 μm wide structure printed from a commercially available composite filament...
March 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28322496/comparison-of-hydrodynamically-closed-two-dimensional-capillary-electrophoresis-coupled-with-ultraviolet-detection-and-hydrodynamically-open-capillary-electrophoresis-hyphenated-with-mass-spectrometry-in-the-bioanalysis-of-varenicline
#6
Juraj Piešťanský, Katarína Maráková, Jaroslav Galba, Andrej Kováč, Peter Mikuš
Two capillary electrophoresis methods for monitoring renally excreted varenicline, a highly effective drug prescribed for smoking cessation, in human urine were developed and compared. A method combining capillary electrophoresis with mass spectrometry was proposed for the fast analysis of varenicline (analysis time up to 7 min). Here, mass spectrometry was a prerequisite for achieving high sensitivity and selectivity of the analysis suitable for the quantification of a 15 ng.mL(-1) level of varenicline in un-pretreated urine matrices...
March 21, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28322043/-sup-18-sup-f-fluoro-hydroxyphenethylguanidines-efficient-synthesis-and-comparison-of-two-structural-isomers-as-radiotracers-of-cardiac-sympathetic-innervation
#7
Yong-Woon Jung, Keun Sam Jang, Guie Gu, Robert A Koeppe, Phillip S Sherman, Carole A Quesada, David M Raffel
Fluorine-18 labeled phenethylguanidines are currently under development in our laboratory as radiotracers for quantifying regional cardiac sympathetic nerve density using PET imaging techniques. In this study, we report an efficient synthesis of <sup>18</sup>F-hydroxyphenethylguanidines consisting of nucleophilic aromatic [<sup>18</sup>F]fluorination of a protected diaryliodonium salt precursor followed by a single deprotection step to afford the desired radiolabeled compound. This approach has been shown to reliably produce 4-[<sup>18</sup>F]fluoro-<i>m</I>-hydroxyphenethylguanidine ([<sup>18</sup>F]4F-MHPG, [<sup>18</sup>F]<b>1</b>) and its structural isomer 3-[<sup>18</sup>F]fluoro-<i>p</i>-hydroxyphenethylguanidine ([<sup>18</sup>F]3F-PHPG, [<sup>18</sup>F]<b>2</b>) with good radiochemical yields...
March 21, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28318588/comparative-composition-diversity-and-abundance-of-oligosaccharides-in-early-lactation-milk-from-commercial-dairy-and-beef-cows
#8
William M Sischo, Diana M Short, Mareen Geissler, Apichaya Bunyatratchata, Daniela Barile
Prebiotics are nondigestible dietary ingredients, usually oligosaccharides (OS), that provide a health benefit to the host by directly modulating the gut microbiota. Although there is some information describing OS content in dairy-source milk, no information is available to describe the OS content of beef-source milk. Given the different trait emphasis between dairy and beef for milk production and calf survivability, it is plausible that OS composition, diversity, and abundance differ between production types...
March 16, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28318004/the-conflicting-role-of-buckled-structure-in-phonon-transport-of-2d-group-iv-and-group-v-materials
#9
Bo Peng, Dequan Zhang, Hao Zhang, Hezhu Shao, Gang Ni, Yongyuan Zhu, Heyuan Zhu
Controlling heat transport through material design is one important step toward thermal management in 2D materials. To control heat transport, a comprehensive understanding of how structure influences heat transport is required. It has been argued that a buckled structure is able to suppress heat transport by increasing the flexural phonon scattering. Using a first principles approach, we calculate the lattice thermal conductivity of 2D mono-elemental materials with a buckled structure. Somewhat counterintuitively, we find that although 2D group-V materials have a larger mass and higher buckling height than their group-IV counterparts, the calculated κ of blue phosphorene (106...
March 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28317706/impact-of-processing-on-odour-active-compounds-of-a-mixed-tomato-onion-puree
#10
Maria Koutidou, Tara Grauwet, Ann Van Loey, Parag Acharya
Gas chromatography-olfactometry revealed thirty-two odour-active compounds in a heat-processed tomato-onion puree, among which twenty-seven were identified by gas chromatography-olfactometry-mass spectrometry (GC-O-MS) and comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry (GC×GC-TOF MS). Based on the results of two olfactometric methods, i.e. detection frequency and aroma extract dilution analysis, the most potent aroma components include: dipropyl disulfide, S-propyl thioacetate, dimethyl trisulfide, 1-octen-3-one, methional, dipropyl trisulfide, 4,5-dimethylthiazole, 2-phenylacetaldehyde and sotolone...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28317396/3d-qsar-studies-pharmacophore-modeling-and-virtual-screening-of-diarylpyrazole-benzenesulfonamide-derivatives-as-a-template-to-obtain-new-inhibitors-using-human-carbonic-anhydrase-ii-as-a-model-protein
#11
Yeganeh Entezari Heravi, Hassan Sereshti, Ali Akbar Saboury, Jahan Ghasemi, Marzieh Amirmostofian, Claudiu T Supuran
A 3D-QSAR modeling was performed on a series of diarylpyrazole-benzenesulfonamide derivatives acting as inhibitors of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1). The compounds were collected from two datasets with the same scaffold, and utilized as a template for a new pharmacophore model to screen the ZINC database of commercially available derivatives. The datasets were divided into training, test, and validation sets. As the first step, comparative molecular field analysis (CoMFA), CoMFA region focusing and comparative molecular similarity indices analysis (CoMSIA) in parallel with docking studies were applied to a set of 41 human (h) CA II inhibitors...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/28317104/contact-and-contagion-bighorn-sheep-demographic-states-vary-in-probability-of-transmission-given-contact
#12
Kezia R Manlove, E Frances Cassirer, Raina K Plowright, Paul C Cross, Peter J Hudson
1.Understanding both contact and probability of transmission given contact are key to managing wildlife disease. However, wildlife disease research tends to focus on contact heterogeneity, in part because probability of transmission given contact is notoriously difficult to measure. Here we present a first step toward empirically investigating probability of transmission given contact in free-ranging wildlife. 2.We used measured contact networks to test whether bighorn sheep demographic states vary systematically in infectiousness or susceptibility to Mycoplasma ovipneumoniae, an agent responsible for bighorn sheep pneumonia...
March 20, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28303718/synthesis-of-polysubstituted-3-amino-pyrroles-via-palladium-catalyzed-multicomponent-reaction
#13
Jianwen Peng, Yang Gao, Chuanle Zhu, Bifu Liu, Yinglan Gao, Miao Hu, Wanqing Wu, Huanfeng Jiang
A novel approach for the synthesis of polysubstituted 3-amino pyrroles via palladium-catalyzed three-component tandem reaction was developed. The procedure constructs various polysubstituted 3-amino pyrroles with moderate to excellent yields under mild reaction conditions with assembly efficiency, readily available starting materials, and good functional group tolerance. Furthermore, this process was successfully applied to the synthesis of different 3-phenyl-1,4-dihydropyrrolo[3,2-b]indole derivatives via an intramolecular Buchwald-Hartwig cross-coupling reaction in two steps...
March 24, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28302506/xanthine-oxidase-inhibitory-activity-of-nicotino-isonicotinohydrazides-a-systematic-approach-from-in-vitro-in-silico-to-in-vivo-studies
#14
Humaira Zafar, Muhammad Hayat, Sumayya Saied, Momin Khan, Uzma Salar, Rizwana Malik, M Iqbal Choudhary, Khalid Mohammed Khan
Change in life style and eating habits has led to an increased prevalence of hyperuricemia worldwide. The role of hyperuricemia is no more restricted to gout, but it has a central role in progression of CVD, hypertension, metabolic syndrome, and arthritis. Among the different factors involved in regulation of serum uric acid, xanthine oxidase (XO) is the best pharmacological target to control the levels of serum uric acid as it catalyzes the final steps in uric acid production. In the current study, a systemic search for the inhibitors of xanthine oxidase, starting from synthesis to in vitro screening and leading to in vivo studies is presented...
February 28, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28298118/quartic-scaling-mp2-for-solids-a-highly-parallelized-algorithm-in-the-plane-wave-basis
#15
Tobias Schäfer, Benjamin Ramberger, Georg Kresse
We present a low-complexity algorithm to calculate the correlation energy of periodic systems in second-order Møller-Plesset (MP2) perturbation theory. In contrast to previous approximation-free MP2 codes, our implementation possesses a quartic scaling, O(N(4)), with respect to the system size N and offers an almost ideal parallelization efficiency. The general issue that the correlation energy converges slowly with the number of basis functions is eased by an internal basis set extrapolation. The key concept to reduce the scaling is to eliminate all summations over virtual orbitals which can be elegantly achieved in the Laplace transformed MP2 formulation using plane wave basis sets and fast Fourier transforms...
March 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28295681/monolithic-flexible-supercapacitors-integrated-into-single-sheets-of-paper-and-membrane-via-vapor-printing
#16
Andong Liu, Peter Kovacik, Nolan Peard, Wenda Tian, Hilal Goktas, Jonathan Lau, Bruce Dunn, Karen K Gleason
A novel approach to fabricate supercapacitors (SCs) via vapor printing, specifically oxidative chemical vapor deposition (oCVD), is demonstrated. Compared to stacking multiple layers into a SC, this method enables the monolithic integration of all components into a single-sheet substrate, minimizing the inactive materials and eliminating the possibility of multilayer delamination. Electrodes comprised of pseudocapacitive material, poly(3,4-ethylenedioxythiophene) (PEDOT), are deposited into both sides of a sheet of flexible porous substrate...
March 10, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28295413/using-a-handheld-stereo-depth-camera-to-overcome-limited-field-of-view-in-simulation-imaging-for-radiation-therapy-treatment-planning
#17
Cesare Jenkins, Lei Xing, Amy Yu
PURPOSE: A correct body contour is essential for reliable treatment planning in radiation therapy. While modern medical imaging technologies provide highly accurate patient modeling, there are times when a patient's anatomy cannot be fully captured or there is a lack of easy access to computed tomography (CT) simulation. Here we provide a practical solution to the surface contour truncation problem by using a handheld stereo depth camera (HSDC) to obtain the missing surface anatomy and a surface-surface image registration to stich the surface data into the CT dataset for treatment planning...
March 11, 2017: Medical Physics
https://www.readbyqxmd.com/read/28291912/improving-the-efficiency-of-breast-radiotherapy-treatment-planning-using-a-semi-automated-approach
#18
Robert A Mitchell, Philip Wai, Ruth Colgan, Anna M Kirby, Ellen M Donovan
OBJECTIVES: To reduce treatment planning times while maintaining plan quality through the introduction of semi-automated planning techniques for breast radiotherapy. METHODS: Automatic critical structure delineation was examined using the Smart Probabilistic Image Contouring Engine (SPICE) commercial autosegmentation software (Philips Radiation Oncology Systems, Fitchburg, WI) for a cohort of ten patients. Semiautomated planning was investigated by employing scripting in the treatment planning system to automate segment creation for breast step-and-shoot planning and create objectives for segment weight optimization; considerations were made for three different multileaf collimator (MLC) configurations...
January 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28290823/-prevalence-of-risk-factors-of-non-communicable-disease-in-kyrgyzstan-assessment-using-who-steps-approach
#19
T A A, S A Makhmutkhodzhaev, R B Kydyralieva, A T Altymysheva, R S Dzhakipova, K S Zhorupbekova, S T Ryskulova, V G Knyazeva, M T Kaliev, A S Dzhumagulova
Assessment of prevalence of risk factors for non-communicable diseases (NCD) based on WHO "STEPS" approach was conducted in Kyrgyzstan. Results of this study demonstrated high prevalence of NCD risk factors: 94.2% of subjects aged 24-64 years had risk factors. Prevalence of elevated blood pressure was 48.7, smoking - 25.7, hypercholesterolemia - 23.6, excessive alcohol consumption - 31.4, physical inactivity 11.4, obesity - 23.1, elevated glucose level - 4.5, diabetes - 8.8, inadequate intake of fruits and vegetables - 74%...
December 2016: Kardiologiia
https://www.readbyqxmd.com/read/28287077/bone-regeneration-in-3d-printing-bioactive-ceramic-scaffolds-with-improved-tissue-material-interface-pore-architecture-in-thin-wall-bone-defect
#20
Huifeng Shao, Xiurong Ke, An Liu, Miao Sun, Yong He, Xianyan Yang, Jianzhong Fu, Yanming Liu, Lei Zhang, Guojing Yang, Sanzhong Xu, Zhongru Gou
Three-dimensional (3D) printing bioactive ceramics have demonstrated alternative approaches to bone tissue repair, but an optimized materials system for improving the recruitment of host osteogenic cells into the bone defect and enhancing targeted repair of the thin-wall craniomaxillofacial defects remains elusive. Herein we systematically evaluated the role of side-wall pore architecture in the direct-ink-writing bioceramic scaffolds on mechanical properties and osteogenic capacity in rabbit calvarial defects...
March 13, 2017: Biofabrication
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