Read by QxMD icon Read

4 Step Approach

Zahra Mohammadi, Mohammad H Entezari
In this research, a facile, one step and eco-friendly sonochemical rout was utilized to the synthesis of a new nanocomposite by Ag nanoparticle anchored on reduced graphene oxide (rGO-Ag-U). Sonication was carried out by using low frequency ultrasound (20 kHz) under ambient condition. In this way, graphene oxide and Ag+ ions simultaneously reduced by polyol without using any additional reactants or capping agents. The polyol serves as both solvent and low toxic reducing agent. To achieve the best synthesis condition of rGO-Ag-U nanocomposite, the effects of irradiation time, ultrasonic amplitude and reaction temperature were investigated...
June 2018: Ultrasonics Sonochemistry
Manon Gilles, Emilie Brun, Cécile Sicard-Roselli
The potential benefit of gold nanoparticles (GNP) to radiotherapy has been demonstrated in a range of cell lines and radiation sources as well as in rodent models, sometimes with contradictory results. Few experimental studies have explored the involved deleterious species, hydroxyl radical being so far the most cited, whereas theoretical studies have usually focused on secondary electrons emitted from GNP, making comparison between these two approaches difficult. Here we focus on the physico-chemical step (i...
April 5, 2018: Journal of Colloid and Interface Science
Carin C C Johansson Seechurn, Ivana Gazić Smilović, Thomas Colacot, Antonio Zanotti-Gerosa, Zdenko Časar
We have elaborated a two-step catalytic approach to nafoxidine, a key precursor to lasofoxifene. Firstly, an efficient α-arylation of 6-methoxy-3,4-dihydronaphthalen-1(2H)-one with chlorobenzene was developed, which operates at low 0.1 mol% Pd-132 catalyst loading in the presence of 1.9 equivalents of sodium tert-butoxide at 60 °C in 1,4-dioxane and provides 6-methoxy-2-phenyl-3,4-dihydronaphthalen-1(2H)-one in 90% yield. Secondly, we have demonstrated that 6-methoxy-2-phenyl-3,4-dihydronaphthalen-1(2H)-one can be converted to nafoxidine in 61% yield via CeCl3 promoted reaction with (4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)lithium, which is formed in-situ from the corresponding arylbromide precursor and n-butyllithium...
April 10, 2018: Bioorganic & Medicinal Chemistry
Astrid M Hoving, Joep Kraeima, Rutger H Schepers, Hildebrand Dijkstra, Jan Hendrik Potze, Bart Dorgelo, Max J H Witjes
BACKGROUND: MRI is the optimal method for sensitive detection of tumour tissue and pre-operative staging in oral cancer. When jawbone resections are necessary, the current standard of care for oral tumour surgery in our hospital is 3D virtual planning from CT data. 3D printed jawbone cutting guides are designed from the CT data. The tumour margins are difficult to visualise on CT, whereas they are clearly visible on MRI scans. The aim of this study was to change the conventional CT-based workflow by developing a method for 3D MRI-based lower jaw models...
2018: PloS One
Dan Mei, Meng Wen, Yuzheng Zhu, Xuemei Xu, Futang Xing
In atmospheric environment, the layout difference of urban buildings has a powerful influence on accelerating or inhibiting the dispersion of particle matters (PM). In industrial cities, buildings of variable heights can obstruct the diffusion of PM from industrial stacks. In this study, PM dispersed within building groups was simulated by Reynolds-averaged Navier-Stokes equations coupled Lagrangian approach. Four typical street building arrangements were used: (a) a low-rise building block with Height/base H/b = 1 (b = 20 m); (b) step-up building layout (H/b = 1, 2, 3, 4); (c) step-down building layout (H/b = 4, 3, 2, 1); (d) high-rise building block (H/b = 5)...
April 20, 2018: Journal of the Air & Waste Management Association
Stefanie S Sebok-Syer, Saad Chahine, Christopher J Watling, Mark Goldszmidt, Sayra Cristancho, Lorelei Lingard
INTRODUCTION: Our ability to assess independent trainee performance is a key element of competency-based medical education (CBME). In workplace-based clinical settings, however, the performance of a trainee can be deeply entangled with others on the team. This presents a fundamental challenge, given the need to assess and entrust trainees based on the evolution of their independent clinical performance. The purpose of this study, therefore, was to understand what faculty members and senior postgraduate trainees believe constitutes independent performance in a variety of clinical specialty contexts...
April 19, 2018: Medical Education
Sonja March, Jamin Day, Kirsty Zieschank, Michael Ireland
BACKGROUND: Early identification of child emotional and behavioral concerns is essential for the prevention of mental health problems; however, few suitable child-reported screening measures are available. Digital tools offer an exciting opportunity for obtaining clinical information from the child's perspective. OBJECTIVE: The aim of this study was to describe the initial development and pilot testing of the Interactive Child Distress Screener (ICDS). The ICDS is a Web-based screening instrument for the early identification of emotional and behavioral problems in children aged between 5 and 12 years...
April 19, 2018: JMIR MHealth and UHealth
Austin Hensley, Jess Rames, Victor Casler, Christopher Rood, Joshua Walters, Christopher Fernandez, Sanjitpal Gill, Jeremy Mercuri
Intervertebral disc (IVD) degeneration is a multi-factor process that results in the physical destruction of the nucleus pulposus (NP) and annulus fibrosus (AF). This compromises IVD function and causes significant disability and economic burden. Strategies to replace the entire composite structure of the IVD are limited and most approaches do not recapitulate the heterogenous biochemical composition, micro-architecture or mechanical properties of the native tissue. Our central hypothesis was that donor IVDs which resemble the size and biochemistry of human lumbar IVDs could be successfully decellularized while retaining the tissue's structure and function with the long-term goal of creating a composite scaffold for tissue engineering the human IVD...
April 19, 2018: Journal of Biomedical Materials Research. Part A
Pierre-Marc Brousseau, Dominique Gravel, I Tanya Handa
1.The characterization of ecological communities with functional traits allows to consider simultaneously the ability of a species to survive and reproduce in an environment, its interactions with other species, and its effects on the ecosystem. 2.Functional traits have been studied mainly by plant ecologists, but are increasingly common in the study of other taxa including arthropods. Arthropods represent a group for which a functional trait approach could be highly profitable because of their high diversity, abundance, ubiquity and role in many important ecological processes...
April 19, 2018: Journal of Animal Ecology
Kanta Kumar, Sabrina R Raizada, Christian D Mallen, Rebecca J Stack
Background: Rheumatoid arthritis (RA) causes painful joint inflammation and is incurable, but treatments control RA. Drug regimens are complex, and patients often do not take their medication as expected. Poor medication adherence can lead to poorly controlled disease and worse patient outcomes. Biologics treatments are expensive and require full engagement from patients. We have previously shown that patients from Black ethnic minority backgrounds do not fully engage into treatment plan...
2018: Patient Preference and Adherence
Simon N Rogers, Derek Lowe, Cher Lowies, Seow Tien Yeo, Christine Allmark, Dominic Mcavery, Gerald M Humphris, Robert Flavel, Cherith Semple, Steven J Thomas, Anastasios Kanatas
BACKGROUND: The consequences of treatment for Head and Neck cancer (HNC) patients has profound detrimental impacts such as impaired QOL, emotional distress, delayed recovery and frequent use of healthcare. The aim of this trial is to determine if the routine use of the Patients Concerns Inventory (PCI) package in review clinics during the first year following treatment can improve overall quality of life, reduce the social-emotional impact of cancer and reduce levels of distress. Furthermore, we aim to describe the economic costs and benefits of using the PCI...
April 18, 2018: BMC Cancer
Frank M Hauser, Janneke W Hulshof, Thorsten Rößler, Ralf Zimmermann, Michael Pütz
Chemical waste from the clandestine production of amphetamine is of forensic and environmental importance due to its illegal nature which often leads to dumping into the environment. In this study 27 aqueous amphetamine waste samples from controlled Leuckart reactions performed in Germany, the Netherlands and Poland were characterised to increase the knowledge about the chemical composition and physicochemical characteristics of such waste. Aqueous waste samples from different reaction steps were analysed to determine characteristic patterns which could be used for classification...
April 18, 2018: Drug Testing and Analysis
Jason F Talbott, Daniel L Cooke, Marc C Mabray, Paul S Larson, Matthew R Amans, Steven W Hetts, Mark W Wilson, Terilyn Moore, Ernesto A Salegio
PURPOSE: To evaluate the accuracy of percutaneous fluoroscopic injection into the spinal cord of a spine phantom utilizing integrated navigational guidance from fused flat panel detector CT (FDCT) and MR datasets. Conventional and convection-enhanced delivery (CED) techniques were evaluated. MATERIALS AND METHODS: FDCT and MR datasets of a swine thoracic spine phantom were co-registered using an integrated guidance system and surface to spinal cord target trajectory planning was performed on the fused images...
April 17, 2018: Journal of Neurointerventional Surgery
R Bethune, N Absher, M Obiagwu, T Qarmout, M Steeves, M Yaghoubi, R Tikoo, M Szafron, C Dell, M Farag
OBJECTIVE: In Canada, indigenous peoples suffer from a multitude of health disparities. To better understand these disparities, this study aims to examine the social determinants of self-reported health for indigenous peoples in Canada. STUDY DESIGN: This study uses data from Statistics Canada's Aboriginal Peoples Survey 2012. METHODS: Multinomial logistic regression models were used to examine how selected social determinants of health are associated with self-reported health among off-reserve First Nations and Métis peoples in Canada...
April 14, 2018: Public Health
Lara Campesato, Tainah Dorina Marforio, Pietro Giacinto, Matteo Calvaresi, Andrea Bottoni
We investigated the catalytic mechanism of α-1,4-glucan lyases using a full QM DFT approach based on the M06-2X functional. The reaction profile of the whole catalytic process can be divided into three phases: glycosylation, deglycosylation-elimination and tautomerization. Glycosylation is a highly asynchronous SN 1-like process with an energy barrier of 10.2 kcal mol-1 . A proton moves from the Asp665 residue to the glycosidic oxygen. Asp553 acts as a nucleophile and attacks the anomeric carbon causing the cleavage of the glycosidic bond...
April 17, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
Katherine Albutt, Rachel R Yorlets, Maria Punchak, Peter Kayima, Didacus B Namanya, Geoffrey A Anderson, Mark G Shrime
BACKGROUND: Five billion people lack access to safe, affordable, and timely surgical and anesthesia care. Significant challenges remain in the provision of surgical care in low-resource settings. Uganda is no exception. METHODS: From September to November 2016, we conducted a mixed-methods countrywide surgical capacity assessment at 17 randomly selected public hospitals in Uganda. Researchers conducted 35 semi-structured interviews with key stakeholders to understand factors related to the provision of surgical care...
2018: PloS One
Bhaskar Sen, Neil C Borle, Russell Greiner, Matthew R G Brown
This work presents a novel method for learning a model that can diagnose Attention Deficit Hyperactivity Disorder (ADHD), as well as Autism, using structural texture and functional connectivity features obtained from 3-dimensional structural magnetic resonance imaging (MRI) and 4-dimensional resting-state functional magnetic resonance imaging (fMRI) scans of subjects. We explore a series of three learners: (1) The LeFMS learner first extracts features from the structural MRI images using the texture-based filters produced by a sparse autoencoder...
2018: PloS One
Ju-Chuan Hu, Chuan-Shu Chen
OBJECTIVE: To describe the methodology of transurethral seminal vesiculoscopy and the anatomy of the seminal tract, and to report a single-surgeon experience with this procedure. METHODS: A total of 38 consecutive patients with intractable macroscopic hemospermia were enrolled from January 2010 to July 2016. A 6/7.5-Fr semirigid ureteroscope was used to enter the seminal tract by one of these two approaches: through either a trans-ejaculatory duct opening or a trans-utricle fenestration...
April 17, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
Kurt P Schulz, Beth Krone, Lenard A Adler, Anne-Claude V Bédard, Stephanie Duhoux, Juan Pedraza, Sanweda Mahagabin, Jeffrey H Newcorn
BACKGROUND: Prefrontal-limbic circuits that form the neural architecture for emotion to influence behavior have been implicated in the pathophysiology of attention-deficit/hyperactivity disorder (ADHD) and represent a potentially important target of medication treatment that has not been substantively evaluated. This study tested the effect of the psychostimulant prodrug lisdexamfetamine dimesylate on amygdala activation and connectivity during the emotional bias of response execution and inhibition...
March 19, 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Yuka Noguchi, Rikako Takeda, Keisuke Suzuki, Ken Ohmori
The first total synthesis of selligueain A (4), a plant-derived sweet polyphenol, has been achieved. The key step was the de novo synthetic approach to the selectively protected epiafzelechin unit 10, which was divergently converted to three flavan units 7, 8, and 9. These components were combined by an orthogonal activation and annulation method, enabling assembly of the characteristic trimeric structure with single and double interflavan linkages.
April 16, 2018: Organic Letters
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"