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Hepatology, HIV,

V Filingeri, S Francioso, D Sforza, F Santopaolo, F M Oddi, G Tisone
OBJECTIVE: In the last decades, liver biopsy was the reference procedure for the diagnosis and follow-up of liver disease. Aim of present retrospective analysis was to assess the prevalence of complications and risk factors after Percutaneous Liver Biopsy (PLB) performed for diagnosis and staging in patients with chronic liver disease and for monitoring the graft in liver transplanted patients PATIENTS AND METHODS: Data were collected from a total of 1.011 PLB performed with the Menghini technique between January 2004 and December 2014 at the Hepatology and Transplant Units of the University of Rome Tor Vergata...
September 2016: European Review for Medical and Pharmacological Sciences
Natalie F Shur, Yishi Tan, Stephanie Goubet, Martin Fisher, Yvonne Gilleece, Sumita Verma
Recent advances in antiviral therapy have improved outcomes in HIV-positive individuals co-infected with hepatitis B and C virus (HBV/HCV). Our aim was to assess prevalence and predictors of chronic liver disease (CLD) due to the metabolic syndrome (MS), alcohol and antiretrovirals (ARVs) use in HIV-monoinfected individuals. This was a retrospective cohort study (2005-2012). HIV-positive patients with negative HBV/HCV serology and at least two elevated alanine aminotransferase (ALT) levels six months apart were included...
June 5, 2016: AIDS Care
Amar Mahgoub, Clifford J Steer
Acute and chronic liver disease continue to result in significant morbidity and mortality of patients, along with increasing burden on their families, society and the health care system. This in part is due to increased incidence of liver disease associated factors such as metabolic syndrome; improved survival of patients with chronic predisposing conditions such as HIV; as well as advances in the field of transplantation and associated care leading to improved survival. The fact that one disease can result in different manifestations and outcomes highlights the need for improved understanding of not just genetic phenomenon predisposing to a condition, but additionally the role of epigenetic and environmental factors leading to the phenotype of the disease...
2016: Journal of Clinical Medicine
Fernando Agüero, Alejandro Forner, Christian Manzardo, Andres Valdivieso, Marino Blanes, Rafael Barcena, Antoni Rafecas, Lluis Castells, Manuel Abradelo, Julian Torre-Cisneros, Luisa Gonzalez-Dieguez, Magdalena Salcedo, Trinidad Serrano, Miguel Jimenez-Perez, Jose Ignacio Herrero, Mikel Gastaca, Victoria Aguilera, Juan Fabregat, Santos Del Campo, Itxarone Bilbao, Carlos Jimenez Romero, Asuncion Moreno, Antoni Rimola, Jose M Miro
UNLABELLED: The impact of human immunodeficiency virus (HIV) infection on patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC) is uncertain. This study aimed to assess the outcome of a prospective Spanish nationwide cohort of HIV-infected patients undergoing LT for HCC (2002-2014). These patients were matched (age, gender, year of LT, center, and hepatitis C virus (HCV) or hepatitis B virus infection) with non-HIV-infected controls (1:3 ratio). Patients with incidental HCC were excluded...
February 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Kenneth E Sherman, Juergen Rockstroh, David Thomas
UNLABELLED: Human immunodeficiency viral (HIV) infection affects approximately 1.2 million persons in the United States and 35 million worldwide. Progression to advanced liver disease remains a leading cause of death among HIV-infected persons in the United States and elsewhere. Though mortality from HIV complications has been dramatically reduced wherever effective combination antiretroviral therapy is used, there has been little impact on liver-related mortality. Causes of liver disease in the setting of HIV infection include viral hepatitis, nonalcoholic fatty liver disease/nonalcoholic steatohepatitis, drug-associated toxicities, and other metabolic/genetic disorders which interact in an environment modulated by persistent immune activation and altered cytokine display...
December 2015: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Bevin Hearn, Rachel Chasan, Kian Bichoupan, Maria Suprun, Emilia Bagiella, Douglas T Dieterich, Ponni Perumalswami, Andrea D Branch, Shirish Huprikar
BACKGROUND: In the era of combination therapy for human immunodeficiency virus (HIV), liver disease, and hepatocellular carcinoma (HCC) are major causes of death for patients coinfected with HIV and hepatitis B virus (HBV). This study compared HIV provider and hepatologist awareness of and adherence to the American Association for the Study of Liver Diseases (AASLD) practice guidelines for chronic HBV management. The primary endpoint of HIV provider adherence to HCC screening recommendations was compared to that of hepatologists at a large metropolitan academic medical center...
December 1, 2015: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Ibrahim M Sayed, Ann-Sofie Vercouter, Sayed F Abdelwahab, Koen Vercauteren, Philip Meuleman
Hepatitis E virus (HEV) is yearly responsible for approximately 20 million infections worldwide. Although most infections occur in developing countries, HEV appears to be an emerging problem in several industrialized countries, where it is mostly associated with either traveling to an HEV endemic area or contact with pigs, which represent a major reservoir of HEV. The major risk groups for HEV infection and its ensuing complications are elderly men, pregnant women, young children, immunocompromised patients, patients with preexisting liver disease, and workers that come into close contact with HEV-infected animals...
December 2015: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Giada Sebastiani, Kathleen C Rollet-Kurhajec, Costa Pexos, Norbert Gilmore, Marina B Klein
Background.  Longitudinal data on liver disease in human immunodeficiency virus (HIV) mono-infection are scarce. We used noninvasive serum biomarkers to study incidence and predictors of hepatic steatosis and fibrosis. Methods.  Hepatic steatosis was diagnosed by hepatic steatosis index ≥36. Advanced liver fibrosis was diagnosed by fibrosis-4 index >3.25. Kaplan-Meier analysis was used to estimate incidences. Cox regression analysis was used to explore predictors of hepatic steatosis and fibrosis development...
January 2015: Open Forum Infectious Diseases
Barbara J Turner, Barbara S Taylor, Joshua T Hanson, Mary Elizabeth Perez, Ludivina Hernandez, Roberto Villarreal, Poornachand Veerapaneni, Kristin Fiebelkorn
BACKGROUND/OBJECTIVE: The US Preventive Services Task Force recommends 1-time hepatitis C virus (HCV) screening of all baby boomers (born 1945-1965). However, little is known about optimal ways to implement HCV screening, counseling, and linkage to care. We developed strategies following approaches used for HIV to implement baby boomer HCV screening in a hospital setting and report results as well as costs. DESIGN/PATIENTS: Prospective cohort of 6140 baby boomers admitted to a safety-net hospital in South Texas from December 1, 2012 to January 31, 2014 and followed to December 10, 2014...
August 2015: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
V Filingeri, D Sforza, G Tisone
OBJECTIVE:   Liver biopsy is a very important investigation in Hepatology. The aim of this retrospective study was to assess the prevalence of complications after Percutaneous Liver Biopsy (PLB), performed in two groups of patients with liver transplantation or with liver disease. We compared our results with those most representative of the literature and discussed about indications, advantages and disadvantages in relation to the different modes for the execution of this procedure, with particular regard to the use of ultrasound guidance...
2015: European Review for Medical and Pharmacological Sciences
Alexis Ogdie, Wyki Gina Pang, Kimberly A Forde, Bhangle D Samir, Lakeisha Mulugeta, Kyong-Mi Chang, David E Kaplan, Valerianna K Amorosa, Jay R Kostman, Rajender K Reddy, Ralph H Schumacher, Vincent Lo Re
BACKGROUND: To determine the prevalence of patient-reported joint pain among patients with human immunodeficiency virus (HIV)/chronic hepatitis C virus (HCV) coinfection, chronic HCV monoinfection, and HIV monoinfection followed in hepatology and infectious disease outpatient practices. METHODS: Standardized interviews were performed among 79 HIV/HCV-coinfected, 93 HCV-monoinfected, and 30 HIV-monoinfected patients in a cross-sectional study within hepatology and infectious disease clinics at three centers...
2015: BMC Musculoskeletal Disorders
Timo Vesikari, Pierre Van Damme, Carlo Giaquinto, Ron Dagan, Alfredo Guarino, Hania Szajewska, Vytautas Usonis
The first evidence-based recommendations for rotavirus (RV) vaccination in Europe were prepared at the time of licensure of 2 live oral RV vaccines (Rotarix, GlaxoSmithKline Biologicals, and RotaTeq, Sanofi Pasteur MSD) in 2006 and published in 2008. Since then several countries in Europe and more globally have adopted universal RV vaccination of all healthy infants as part of their national immunization programs (NIPs). The experience from these NIPs has produced a wealth of post-introduction effectiveness data that, together with the evidence from prelicensure efficacy trials presented in the 2008 Recommendations, support the case of RV vaccination in Europe...
June 2015: Pediatric Infectious Disease Journal
Renata Fialho, Majella Keller, Alex File, Catherine Woods, Marco Pereira, Elaney Yousseff, Jeremy Tibble, Neil Harrison, Martin Fisher, Jennifer Rusted, Richard Whale
INTRODUCTION: Hepatitis C (HCV) treatment options have changed with the development of direct activity antivirals (DAAs) and the availability of triple therapies have improved HCV cure rates. A common neuropsychiatric side effect of pegylated-interferon and ribavirin treatment is major depressive disorder (MDD), however little is known about such adverse events with protease inhibitor-based triple therapy. The aim of this study was to assess the rate of MDD in co-infected HIV HCV patients undergoing different HCV treatments...
2014: Journal of the International AIDS Society
Guillaume Geri, Marianne Maynard, Eric Rosenthal, Hélène Fontaine, Karine Lacombe, Laurence Slama, Cécile Goujard, Véronique Loustaud-Ratti, Jean-François Bergmann, Philippe Morlat, Daniel Vittecoq, Laurent Alric, Patrice Cacoub
BACKGROUND & AIMS: To determine the characteristics of hepatitis C (HCV)- infected patients in 2010 and compare this survey with those reported in 1995 and 2001. PATIENTS AND METHODS: Observational multicentre study conducted in 2010 in French internal medicine, infectious diseases and hepatology departments. RESULTS: A total of 1621 HCV infected patients (mean age 50.1 ± 10.7 years; sex ratio M/F 1.8; genotype 1: 55.7%) were included. Of these, 910 (56...
October 2014: Liver International: Official Journal of the International Association for the Study of the Liver
Xi-Hong Liu, Zong-Yi Ding
The history of breast milk banks is over 100 years. Most of the milk banks were closed because of HIV in the 80's. But more and more milk banks are re-opening and new ones are being established as the composition and superiority of breast milk are recognized again. The Human Milk Banking Association of North America and European Milk Bank Association have been set up and they have established and revised the standards and guidelines of breast milk banks. There is no doubt of the clinical effects of donor human milk on preterm infants worldwide...
July 2014: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
Betsy Escobar, Victoria N Maldonado, Sofia Ansari, Juan C Sarria
PATIENT: Female, 51 FINAL DIAGNOSIS: Gastrointestinal histoplasmosis Symptoms: Abdominal pain • nausea • vomiting MEDICATION: - Clinical Procedure: - Specialty: Gastroenterology and Hepatology. OBJECTIVE: Adverse events of drug therapy. BACKGROUND: Gastrointestinal involvement in patients with disseminated histoplasmosis is considered common since the organism is identified in the GI tract of approximately 70-90% of autopsy cases...
2014: American Journal of Case Reports
Mariusz Łucejko, Anna Grzeszczuk, Magdalena Rogalska, Robert Flisiak
INTRODUCTION: According to WHO data, among patients infected with HIV, tuberculosis occurs in about 30% of patients and causes approximately 25% of deaths due to AIDS worldwide. The incidence rate of tuberculosis in the Polish population was 22.2/100,000 in 2011, while the average in European Union countries in 2011 was 14/100,000. Since 1985 to 30 April 2013 HIV infection in Poland was confirmed in 16,588 patients, while the number of reported tuberculosis cases in HIV-infected individuals in 2011 was 26...
2013: Pneumonologia i Alergologia Polska
Edward R Cachay, Lucas Hill, Craig Ballard, Bradford Colwell, Francesca Torriani, David Wyles, William C Mathews
BACKGROUND: Access to Hepatitis C (HCV) care is low among HIV-infected individuals, highlighting the need for new models to deliver care for this population. METHODS: Retrospective cohort analysis that compared the number of HIV patients who initiated HCV therapy: hepatology (2005-2008) vs. HIV primary care model (2008-2011). Logistic-regression modeling was used to ascertain factors associated with HCV therapy initiation and achievement of sustained viral response (SVR)...
2013: AIDS Research and Therapy
Ziv Ben Ari
In the recent decade the subject of general hepatology has undergone significant upgrading. Several breakthrough discoveries have lead to substantial improvement in the antiviral treatment of viral hepatitis, the therapy of hepatocellular carcinoma and the development of noninvasive diagnosis of the severity of liver disease. Nonalcoholic fatty liver disease (NAFLD] is now established as one of the most common causes of chronic liver disease in the Western world. NAFLD can progress to cirrhosis and its associated complications...
December 2012: Harefuah
Jason Grebely, Jordan J Feld, Tanya Applegate, Gail V Matthews, Margaret Hellard, Alana Sherker, Kathy Petoumenos, Geng Zang, Ineke Shaw, Barbara Yeung, Jacob George, Suzy Teutsch, John M Kaldor, Vera Cherepanov, Julie Bruneau, Naglaa H Shoukry, Andrew R Lloyd, Gregory J Dore
UNLABELLED: Systemic levels of interferon-gamma-inducible protein-10 (IP-10) are predictive of treatment-induced clearance in chronic hepatitis C virus (HCV). In the present study, factors associated with plasma IP-10 levels at the time of acute HCV detection and the association between IP-10 levels and spontaneous clearance were assessed in three cohorts of acute HCV infection. Among 299 individuals, 245 (181 male, 47 human immunodeficiency virus-positive [HIV+]) were HCV RNA+ at acute HCV detection...
June 2013: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
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