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Mesencyhmal Stem Cells

E Ragni, M Lommel, M Moro, M Crosti, C Lavazza, V Parazzi, S Saredi, S Strahl, L Lazzari
Human mesenchymal stem cells (MSC) are promising cell types in the field of regenerative medicine. Although many pathways have been dissected in the effort to better understand and characterize MSC potential, the impact of protein N- or O-glycosylation has been neglected. Deficient protein O-mannosylation is a pathomechanism underlying severe congenital muscular dystrophies (CMD) that start to develop at the embryonic developmental stage and progress in the adult, often in tissues where MSC exert their function...
January 2016: Cellular and Molecular Life Sciences: CMLS
Nimet Bölgen, Petek Korkusuz, İbrahim Vargel, Emine Kılıç, Elif Güzel, Tarık Çavuşoğlu, Duygu Uçkan, Erhan Pişkin
HEMA-Lactate-Dextran cryogel scaffolds were produced by cryogelation. Mesencyhmal stem cells (MSC) were isolated from rat bone marrow. Critical sized cranial bone defects were created in rat cranium. Stem cells were injected inside the macropores of the cryogel scaffolds prepared from HEMA-Lactate-Dextran possessing the same dimensions with the defect and placed in the cranial bone. The cryogels placed in the defect without stem cells served as control. After selected time intervals the experimental sites were removed from the animals and new bone formation and tissue integration were investigated by histological analysis...
February 2014: Artificial Cells, Nanomedicine, and Biotechnology
Adelaide M Carothers, Hira Rizvi, Rian M Hasson, Yvonne I Heit, Jennifer S Davids, Monica M Bertagnolli, Nancy L Cho
Desmoid tumors are nonmalignant neoplasms of mesenchymal origin that mainly contain fibroblast lineage cells. These tumors often occur in patients with familial adenomatous polyposis (FAP) coli who have germ line mutations in the APC gene. Given emerging data that has implicated multipotent mesencyhmal stromal cells (MSC) in the origin of mesenchymal tumors, we hypothesized that desmoid tumors may arise in patients with FAP after MSCs acquire somatic mutations during the proliferative phase of wound healing...
January 1, 2012: Cancer Research
R Seda Tiğli, Chris Cannizaro, Menemşe Gümüşderelioğlu, David L Kaplan
Tissue engineered cartilage can be grown in vitro with the use of cell-scaffold constructs and bioreactors. The present study was designed to investigate the effects of perfusion bioreactors on the chondrogenic potential of engineered constructs prepared from porous silk fibroin scaffolds seeded with human embryonic stem cell (hESC)-derived mesencyhmal stem cells (MSCs). After four weeks of incubation, constructs cultured in perfusion bioreactors showed significantly higher amounts of glycosaminoglycans (GAGs) (p < 0...
January 2011: Journal of Biomedical Materials Research. Part A
Judith A West-Mays, Dhruva J Dwivedi
Keratocytes, also known as fibroblasts, are mesencyhmal-derived cells of the corneal stroma. These cells are normally quiescent, but they can readily respond and transition into repair phenotypes following injury. Cytokines and other growth factors that provide autocrine signals for stimulating wound responses in resident cells are typically presented by platelets at the site of an injury. However, due to the avascular nature of the cornea many of the environmental cues are derived from the overlying epithelium...
2006: International Journal of Biochemistry & Cell Biology
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