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Georgi Tchernev, Yavor Grigorov, Stanislav Philipov, Anastasiya Chokoeva, Uwe Wollina, Torello Lotti, Jose Cardoso, Irina Yungareva, Ilia Lozev, Georgi Konstantinov Maximov
BACKGROUND: Subungual exostosis is a relatively uncommon, benign osteocartilaginous tumor of the distal phalanx of the toes or fingers in young adults, considered as a rare variant of osteochondroma. Differential diagnoses include subungual verruca (viral wart), pyogenic granuloma, osteochondroma, amelanotic subungual melanoma and glomus tumour. Misdiagnosis and total onychodystrophy frequently occur as a result of late treatment or inadequate treatment strategy. Dermoscopy could be a useful technique, involved in the diagnostic process, although X-ray examination and histopathology are mandatory for the diagnosis...
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
Kumail Khandwala, Adeel A Waheed, Muhammad I Alvi, Waseem A Mirza, Masood Umer, Eraj Khurshid
Osteochondroma and synovial chondromatosis are frequently reported benign bony and cartilaginous lesions. Osteochondroma is distinguished by a cartilage-capped bony exostosis on the exterior surface of the bone, whereas synovial chondromatosis is secondary to metaplasia and is characterized by multiple cartilaginous loose bodies within the synovium. We present an atypical case of synovial chondromatosis developing in a bursa sec-ondary to an underlying osteochondroma of the proximal medial tibia in a child...
December 14, 2017: Curēus
David Shahar, Mark G L Sayers
Recently we reported the development of prominent exostosis young adults' skulls (41%; 10-31 mm) emanating from the external occipital protuberance (EOP). These findings contrast existing reports that large enthesophytes are not seen in young adults. Here we show that a combination sex, the degree of forward head protraction (FHP) and age predicted the presence of enlarged EOP (EEOP) (n = 1200, age 18-86). While being a male and increased FHP had a positive effect on prominent exostosis, paradoxically, increase in age was linked to a decrease in enthesophyte size...
February 20, 2018: Scientific Reports
Guiyu Lou, Ke Yang, Litao Qin, Yuwei Zhang, Hongdan Wang, Qiaofang Hou, Miao He, Shixiu Liao
OBJECTIVE To detect potential mutations of the EXT1 and EXT2 genes in a pedigree affected with hereditary multiple exostosis (HME). METHODS For a four-generation family with 7 affected individuals from 17 family members,genomic DNA was extracted from peripheral venous blood samples. All exons of the EXT1 and EXT2 genes were screened for potential mutation by PCR and Sanger sequencing. RESULTS A novel heterozygous frameshift mutation c.1202delT (p.I401Tfs*2)was found in exon 4 of the EXT1 gene in the proband and the other 6 affected individuals...
February 10, 2018: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
V Montiel, M Alfonso, C Villas, A Valentí
BACKGROUND: Exostoses at the base of the distal phalanx of the great toe are usually asymptomatic. The literature has not generally considered them as the origin of a possible problem resulting from a pressure conflict between hallux and shoe (medial aspect) or second toe (lateral aspect) nor a potential complication of surgical correction of hallux valgus deformity. No studies, to our knowledge, have evaluated its possible correlation with other foot disorders. When one of these neglected exostoses became painful after surgical correction of hallux valgus, we decided to start a study to determine their possible origin, prevalence in daily practice and histo-pathological morphology...
November 13, 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
Khodamorad Jamshidi, Tina Shooshtarizadeh, Mehrdad Bahrabadi
Metachondromatosis which was first described in 1971 by Maroteaux is a rare genetic disease consisting of osteochondromas and enchondromas, caused by loss of function of the PTPN11 gene. It is distinct from other cartilaginous tumors such as multiple osteochondromas and hereditary multiple exostosis by the distribution and orientation of lesions, and pattern of inheritance. In Metachondromatosis osteochondromas typically occur in hands, feet, femur, and tibia while enchondromas commonly affect the pelvic bones and femurs...
December 2017: Acta Medica Iranica
Piyush Kumar, Ghuncha Alam
No abstract text is available yet for this article.
January 19, 2018: Indian Journal of Dermatology, Venereology and Leprology
Manish Kanwat, Vivek Jangira, Bhavna Sharma, Dushyant Chauhan
Osteochondroma or exostosis is the most common primary bone tumor containing both bone and cartilage. Soft tissue osteochondromas have been described at various locations, however, to the best of our knowledge, there is only a single case report of a soft tissue osteochondroma around the femoral neck. We, hereby report second such case. CASE REPORT: A forty year old female presented with swelling on medial aspect of left thigh since four years. Radiographs showed a large mass at the inferior surface of the left femoral neck...
November 2017: Journal of Clinical Orthopaedics and Trauma
Cpt Zachary L McBeth, Maj Joseph W Galvin, Ltc Justin Robbins
When insertional Achilles tendinopathy is addressed surgically via a central-Achilles splitting approach, the calcaneal osteotomy has classically been performed from distal to proximal. We describe a simple proximal to distal technique that allows optimal resection of both the calcaneal exostosis and Achilles enthesophyte, minimizes risk to the soft tissues and skin, provides a bony attachment surface parallel to the axis of the Achilles tendon, and avoids the risk of osteotomy extension into the subtalar joint...
January 1, 2018: Foot & Ankle Specialist
Hosseinali Abdolrazaghi, Azade Riyahi, Morteza Taghavi, Pezhman Farshidmehr, Abolfazl Mohammadbeigi
We report a rare case of multiple hereditary exostosis where patient presented with bilateral base of neck exostoses with concurrent compression of brachial plexus and subclavian artery and vein. The patient was a young 26-year-old woman with chief complaints of pain in the left upper extremity, paresthesia in the left ring and little finger, and weakness in hand movement and grip. On referral, history, physical examination, radiological imaging, and electrodiagnostic tests evaluated the patient. Due to severe pain and disability in performing routine activities, surgical intervention was necessary...
January 2018: Annals of Cardiac Anaesthesia
Kaili Du, Zhenkai Lou, Chunqiang Zhang, Peiyu Guo, Lingqiang Chen, Bing Wang, Dongsheng Huang
BACKGROUND: Spinal osteochondroma is a rare but recognized cause of myelopathy. Brown-Sequard syndrome is a form of severe myelopathy characterized by a clinical picture of hemisection of the spinal cord. Brown-Sequard syndrome caused by osteochondroma is extremely rare, calling for individualized surgical procedures. CASE DESCRIPTION: We reveal a 16-year-old girl with hereditary multiple exostoses as a rare case of thoracic osteochondroma causing partial Brown-Sequard syndrome...
December 16, 2017: World Neurosurgery
Giuseppe Marangi, Marilena C Di Giacomo, Serena Lattante, Daniela Orteschi, Sara Patrizi, Paolo N Doronzio, Francesco N Riviello, Alessandro Vaisfeld, Silvia Frangella, Marcella Zollino
KAT6B sequence variants have been identified in both patients with the Say-Barber-Biesecker-Young-Simpson syndrome (SBBYSS) and in the genitopatellar syndrome (GPS). In SBBYSS, they were reported to affect mostly exons 16-18 of KAT6B, and the predicted mechanism of pathogenesis was haploinsufficiency or a partial loss of protein function. Truncating variants in KAT6B leading to GPS appear to cluster within the proximal portion of exon 18, associated with a dominant-negative effect of the mutated protein, most likely...
February 2018: American Journal of Medical Genetics. Part A
S Z Tabakovic, M Mijovic, D Krasic, D Z Tabakovic, B Djerkovic
Intraosseous lipoma appears less frequently in the maxilla than in the mandible. The initial phase of tumor development is characterized by asymptomatic growth, followed by the presence of pain and paresthesia in the later stage. We report the case of a 43-year-old female patient who contacted a doctor because of periodic pains and stupor in the left side of the upper jaw. The exostosis-like formation was found by palpation, subsequently raising suspicion of an odontogenic tumor on the basis of panoramic imaging (dental orthopan)...
November 20, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
Oscar García-González, J Nicolás Mireles-Cano, Natalia Sánchez-Zavala, Miguel A Chagolla-Santillan, Segio M Orozco-Ramirez, Pedro Silva-Cerecedo, Mario Murguia-Perez, Fernando Rueda-Franco
OBJECTIVE: The purpose of the report is to describe a patient with hereditary osteochondromatosis and spinal cord compression at the thoracic level. CLINICAL FEATURES: An 8-year-old patient with hereditary osteochondromatosis inherited from his father presented paraparesis in the left foot, leading to complete paralysis in both legs. INTERVENTION: In a CT scan, a bony tumor rising from the posterior wall of the T3 body narrowing the spinal canal, and the MRI spinal cord compression at the same level and the hydrosyringomyelic cavity extended to the conus medullaris; with an anterior thoracic approach to T2-T4, the fibro-cartilaginous tumor was removed, and the stabilization was completed with bone graft and a plate...
November 11, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Ashish Kumar Singh, Srinivas Sulugodu Ramachandra, Shelly Arora, Daniel Devaprakash Dicksit, C G Kalyan, Priyanshi Singh
Introduction: Oral tori and exostosis are non-pathological bony protuberances seen on the alveolar surfaces of the jaw bones. These are commonly seen on the palatal surfaces of the maxilla [torus palatinus (TP)] and around the premolars in the lingual surface of the mandible [torus mandibularis (TM)]. The aim of this cross-sectional study was to determine the prevalence of tori/exostosis in the Malaysian population. Methodology: A total of 2666 patients were examined for the presence of tori and exostosis in the maxilla and mandible and were categorized into TP, TM, and exostosis (facial/labial)...
September 2017: Journal of Oral Biology and Craniofacial Research
Ahmed I Hammouda, Shawn C Standard, S Robert Rozbruch, John E Herzenberg
BACKGROUND: Different types of external fixators have been used for humeral lengthening with successful outcomes reported in literature. Motorized intramedullary (IM) lengthening nails have been developed as an alternative to external fixators for long bone lengthening in the lower extremity. QUESTIONS/PURPOSES: This case series reports on using the new technology of IM lengthening nails for humeral lengthening. We assessed the radiological healing and functional outcomes after using the PRECICE IM nail for humeral lengthening...
October 2017: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
Chandrakanta Nayak, Barada Prasanna Samal, Sasmita Pradhan
No abstract text is available yet for this article.
September 18, 2017: ANZ Journal of Surgery
Karel Medek, Jiří Zeman, Tomáš Honzík, Hana Hansíková, Štěpánka Švecová, Kamila Beránková, Vendula Kučerová Vidrová, Miloslav Kuklík, Jiří Chomiak, Markéta Tesařová
Hereditary multiple exostoses (HME) represents a heterogeneous group of diseases often associated with progressive skeletal deformities. Most frequently, mutations in EXT1 and EXT2 genes with autosomal dominant inheritance are responsible for HME. In our group of 9 families with HME we evaluated the clinical course of the disease and analysed molecular background using Sanger sequencing and MLPA in EXT1 and EXT2 genes. The mean age in our group of patients, when the first exostosis was recognised was 4.5 years (range 2-10 years) and the number of exostoses per one patient documented on X-ray ranged from 2 to 54...
2017: Prague Medical Report
Md Shahid Alam, Andrea Tongbram, Veena Noronha, Bipasha Mukherjee
No abstract text is available yet for this article.
August 23, 2017: Ophthalmic Plastic and Reconstructive Surgery
Ather Mirza, Justin Mirza, Chris Healy, Vishaaq Mathew, Brian Lee
BACKGROUND: The purpose of the article was to evaluate clinical and radiographic outcomes in a case series of unstable metacarpal fractures treated with flexible intramedullary nail (IMN) fixation. METHODS: A total of 55 patients with unstable metacarpal fractures between 2003 and 2010 were treated with IMN fixation and followed for a minimum of 1 year. The outcomes were assessed via a radiological study of longitudinal and angular collapse, Disabilities of the Arm, Shoulder, and Hand (DASH) score, total active range of motion (ROM) of the wrist, and grip strength testing...
March 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
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