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hypothyroidism in hemodialysis patients

Pedro Iglesias, María Auxiliadora Bajo, Rafael Selgas, Juan José Díez
Thyroid hormones influence renal development, kidney hemodynamics, glomerular filtration rate and sodium and water homeostasis. Hypothyroidism and hyperthyroidism affect renal function by direct renal effects as well as systemic hemodynamic, metabolic and cardiovascular effects. Hypothyroidism has been associated with increased serum creatinine and decreased glomerular filtration rate. The reverse effects have been reported in thyrotoxicosis. Most of renal manifestations of thyroid dysfunction are reversible with treatment...
November 18, 2016: Reviews in Endocrine & Metabolic Disorders
Connie M Rhee, Vanessa A Ravel, Elani Streja, Rajnish Mehrotra, Steven Kim, Jiaxi Wang, Danh V Nguyen, Csaba P Kovesdy, Gregory A Brent, Kamyar Kalantar-Zadeh
CONTEXT AND OBJECTIVE: End-stage renal disease patients have a higher risk of thyroid disease compared with those without kidney disease. Although thyroid dysfunction is associated with higher death risk in the general population and those undergoing hemodialysis, little is known about the effect of thyroid disease upon mortality in patients treated with peritoneal dialysis (PD). Design, Setting, Participants, and Main Outcome: We examined the association of thyroid status, assessed by serum TSH, with all-cause mortality among PD patients from a large national dialysis organization who underwent one or more TSH measurements over 5 years (January 2007 to December 2011)...
November 2016: Journal of Clinical Endocrinology and Metabolism
Maryam Pakfetrat, Mohammad Hossein Dabbaghmanesh, Zahed Karimi, Alireza Rasekhi, Leila Malekmakan, Mohammad Hossein Nikoo
INTRODUCTION: End stage renal disease (ESRD) reasons several changes in the function of thyroid gland as; lower levels of thyroid hormones, altered hormone metabolism, and increased iodine storage. The aim of this study was to evaluate the prevalence of nodular goiter and hypothyroidism in hemodialysis (HD) patients compared with normal population. METHODS: This cross-sectional study was conducted among HD patients and healthy people as the control group for thyroid function evaluation...
January 2017: Hemodialysis International
Abbas Ali Tasneem, Asad Ali Khan, Zaigham Abbas, Nasir Hassan Luck, Syed Mujahid Hassan
OBJECTIVE: To describe the causes, characteristics and factors associated with ascites in patients on maintenance hemodialysis. STUDY DESIGN: Observational study. PLACE AND DURATION OF STUDY: Department of Hepatogastroenterology, Sindh Institute of Urology and Transplantation, Karachi, from November 2007 to November 2014. METHODOLOGY: All patients on maintenance hemodialysis and age > 16 years with ascites were included...
May 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Mohammad Reza Abassi, Amin Safavi, Masoumeh Haghverdi, Babak Saedi
Kidney failure affects different aspects of normal life. Among different manifestations, sleep problem can be considered as a common complaint of ESRD (End Stage Renal Disease) patients. In this study, we aimed to investigate the interrelationship between sleep disorders in ESRD patients and their characteristics. Through a cross-sectional study (2010-2011), 88 ESRD patients undergoing maintenance hemodialysis thrice weekly were recruited to enter the study. We used a self-administered questionnaire into which the data were reflected...
March 2016: Acta Medica Iranica
Selma Jusufovic, Emir Hodzic
INTRODUCTION: Thyroid function disorders are common in patients with chronic kidney disease. The aim of this study was to compare thyroid function among patients on chronic hemodialysis (HD) and healthy participants and to assess duration of dialysis on thyroid disorders. MATERIAL AND METHODS: Prospective study included 80 participants divided in two groups. Study group included 40 patients on HD who were divided in two subgroups, according to time on dialysis (under and over 72 months)...
2011: Materia Socio-medica
Ana Beatriz B A Da Costa, Caio Pellizzari, Gisah A Carvalho, Beatriz C Sant'Anna, Rafaela L Montenegro, Roberto G Zammar Filho, Cleo O Mesa Junior, Patrícia R Hauck Prante, Marcia Olandoski, Mauricio Carvalho
Chronic kidney disease has been known to affect thyroid hormone metabolism. Low serum levels of T3 and T4 are the most remarkable laboratorial findings. A high incidence of goiter and nodules on thyroid ultrasonography has been reported in patients with end-stage renal disease (ESRD). Our objective is to evaluate the prevalence of laboratorial and morphologic alterations in the thyroid gland in a cohort of patients with ESRD on hemodialysis (HD). Sixty-one patients with ESRD on HD were selected and compared with 43 healthy subjects matched by age, gender, and weight...
January 2016: Hemodialysis International
Karim Zouaghi, Lilia Ben Fatma, Saida Hajri, Rania Khedher, Madiha Krid, Wided Smaoui, Soumaya Béji, Lamia Rais, Fatma Ben Moussa
Crow-Fukase syndrome, also known as POEMS syndrome, is a rare plasma dyscrasia characterized by monoclonal gammopathy and various combinations of polyneuropathy, organomegaly, endocrinopathy and dermatological changes, and their initials stand for the acronym POEMS. Substantial kidney involvement is rarely related to this disease. Our report is about five patients suffering from the POEMS syndrome with kidney involvement that rapidly progressed to end-stage renal disease. Our report is about three females and two males with a mean age of 60...
July 2015: Saudi Journal of Kidney Diseases and Transplantation
Alma Halilcevic, Emir Hodzic, Enisa Mesic, Senaid Trnacevic
UNLABELLED: Thyroid disorders are common in chronic kidney disease. THE AIM: The purpose of this study was to compare thyroid gland disorders among healthy participants and renal transplant patients and to assess the duration of dialysis on thyroid disorders before transplantation. MATERIAL AND METHODS: Prospective study during 12 months period included 80 participants divided into two groups. Study group of 40 patients with transplanted kidney was divided in two subgroups, according to the time spent on dialysis (i...
April 2015: Materia Socio-medica
Yahya Osman Malik, Syed Mohsin Raza, Sophia Arunselvan
INTRODUCTION: The clinical syndrome of uremia is a bedside diagnosis which mimics a wide spectrum of other clinical disorders, most commonly thyroid disease. End-stage renal disease (ESRD), as a disorder, frequently alters thyroid hormone metabolism, and this is not significantly normalized by dialysis. Although the thyroid and parathyroid glands are considered independent organs, their anatomical juxtaposition in the neck, as well as sharing a common embryological origin, might play a role in some of the possible association between thyroid and parathyroid disease...
March 2015: Nephro-urology Monthly
Maurizio Bossola, Luigi Tazza
The increased frequency of cardiovascular disease observed in hemodialysis patients is secondary to the combination of many traditional (age, male sex, hypertension, smoking, diabetes mellitus, and dyslipidemia) and novel and uremia-related (inflammation, uremic toxins, adipokine imbalance, coagulation disorders, protein-energy wasting, volume overload, endothelial dysfunction, hyperparathyroidism, and subclinical hypothyroidism) risk factors. Usually, in the latter group, oxidative stress is included. However, after decades of research, it remains essentially unknown if oxidative stress has a causative role in the development of cardiovascular disease in long-term hemodialysis patients because adequate longitudinal studies are lacking...
May 2015: Seminars in Dialysis
Connie M Rhee, Steven Kim, Daniel L Gillen, Tolga Oztan, Jiaxi Wang, Rajnish Mehrotra, Sooraj Kuttykrishnan, Danh V Nguyen, Steven M Brunelli, Csaba P Kovesdy, Gregory A Brent, Kamyar Kalantar-Zadeh
CONTEXT: Hypothyroidism is a common condition that disproportionately affects hemodialysis patients. In the general population, hypothyroidism is associated with higher mortality, particularly in populations with underlying cardiovascular risk. Despite their heightened cardiovascular mortality, the impact of hypothyroidism on the survival of hemodialysis patients remains uncertain. OBJECTIVE: To examine whether hypothyroidism is independently associated with higher mortality in hemodialysis patients...
April 2015: Journal of Clinical Endocrinology and Metabolism
Toru Sanai, Ken Okamura, Tomoya Kishi, Motoaki Miyazono, Yuji Ikeda, Takanari Kitazono
BACKGROUND/AIM: We evaluated the thyroid function in end-stage renal disease (ESRD) on maintenance hemodialysis. MATERIAL/METHODS: Thyroid function and clinical hypothyroid score were evaluated in 145 ESRD patients. RESULTS: Comparison of thyroid function between 127 ESRD patients, excluding 18 patients with suppressed or elevated serum TSH level, and age/sex-matched healthy controls (76 in midlife group aged under 65 and 51 in late-life group aged 65 or over) using a multivariate logistic regression analysis suggested significant difference (P < 0...
January 2015: Journal of Endocrinological Investigation
Klara Paudel
BACKGROUND: The prevalence of hypothyroidism in persons with chronic kidney disease is documented to be higher, compared to the normal population. However, no data is available about the prevalence rate of hypothyroidism among hemodialysis patients in Nepal. METHODS: A cross-sectional analysis was done on consecutive patients enrolled for maintenance hemodialysis in the Hemodialysis Unit of Gandaki Medical College Teaching Hospital, Pokhara, Nepal, during the period of one year (1(st) January 2011 to 31(st) December 2011)...
April 2014: Journal of Clinical and Diagnostic Research: JCDR
Erhan Tatar, Tolgay Isikyakar, Kezban Pinar Yeniay, Hasan Huseyin Uzuner, Ebru Sevinc Ok
Hypothyroidism occurs relatively common and is a significant cause of morbidity and mortality during the course of chronic kidney disease. Rhabdomyolysis is a potentially life-threatening condition characterised by necrosis of muscular tissue and rarely associates with hypothyroidism. Here we describe a case of rhabdomyolysis due to severe hypothyroidism in a 56-year-old female hemodialysis patient.
2014: Case Reports in Medicine
Gaosi Xu, Wenjun Yan, Jingzhen Li
Nonthyroidal illness syndrome (NTIS) is widely found in the patients with chronic kidney disease (CKD) or critical illness. However, the exact pathogenesis and reasonable treatment remain unclear. To identify suitable studies for inclusion in present review, a search for articles using PubMed search engine with combined terms: (thyroid OR hypothyroidism OR hyperthyroidism OR triiodothyronine) AND (glomerulonephritis OR chronic kidney disease OR chronic renal failure OR end stage renal disease OR hemodialysis OR peritoneal dialysis OR kidney transplantation OR renal transplantation) was performed...
December 2014: Clinical and Experimental Nephrology
Christiane Drechsler, Andreas Schneider, Lena Gutjahr-Lengsfeld, Matthias Kroiss, Juan Jesús Carrero, Vera Krane, Bruno Allolio, Christoph Wanner, Martin Fassnacht
BACKGROUND: In dialysis patients, the prevalence of thyroid disorders and their impact on specific cardiovascular (CV) events and mortality are largely unknown. The aim of the present study was to analyze whether subclinical thyroid disorders were associated with CV events and mortality. STUDY DESIGN: Prospective multicenter cohort study. SETTING & PARTICIPANTS: Thyroid status and clinical outcomes were explored in 1,000 diabetic hemodialysis patients from 178 centers in Germany...
June 2014: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Yee Yung Ng, Hong Da Lin, Shiao Chi Wu, Chih Yu Yang, Wu Chang Yang, Hung Hsiang Liou, Fen Hsiang Hu, Chun Cheng Hou, Su Shan Tseng, Nai Yung Ku, Nien Yung Hsiao, Wen Chieh Wu, Hsing Meng Tu, Tse-Jen Lien, Chung Ching Lee, Kwong Kee Tsang, Chen Seng Cheng, Jean Hu, Ru Ping Lin
BACKGROUND: Although thyroid diseases exist in patients with renal failure, thyroid function tests are not routine tests in patients on chronic hemodialysis (HD). Therefore, the impact of thyroid diseases on erythropoietin (EPO) dosage in HD patients is not well defined. This study evaluated the relationship between the dose of EPO and the presence or absence of thyroid dysfunction in HD patients. METHODS: This study included 1013 adult patients on HD who did not have a malignancy, liver cirrhosis, thalassemia, iron deficiency, gastrointestinal bleeding, or a major operation within 6 months...
May 2013: Thyroid: Official Journal of the American Thyroid Association
Jenn Yeu Wang, Betau Hwang, Yuh Feng Lin, Jen-Dar Chen
In this report, the clinical characteristics of a 65-year-old female patient with tricuspid regurgitation, ischemic cardiomyopathy, congestive heart failure, and chronic renal failure were retrospectively evaluated. Laboratory studies revealed cardiogenic ascites coincided with nephrogenic ascites and subclinical amiodarone-induced hypothyroidism. The ascites of the patient was responsive to management of congestive heart failure and therapeutic paracentesis during the first episode, add-on therapy with intensified hemodialysis during the second episode, and add-on therapy with low-dose eltroxin during the third episode...
2012: Renal Failure
Elif Comak, Mustafa Koyun, Bahar Kiliçarslan-Akkaya, Iffet Bircan, Sema Akman
Hypothyroidism has been reported rarely as the cause of rhabdomyolysis in adults and children. We present here a non-compliant adolescent with a diagnosis of hypothyroidism who developed rhabdomyolysis and acute renal failure with no additional predisposing factor. A 13-year-old girl with a previous history of hypothyroidism due to thyroid hypoplasia presented with generalized myalgia, malaise, vomiting, and oliguria lasting for three days. Neurological examination revealed bilateral marked weakness and tenderness of muscles of both lower and upper extremities...
September 2011: Turkish Journal of Pediatrics
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