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https://www.readbyqxmd.com/read/27880794/phylogeography-of-crimean-congo-hemorrhagic-fever-virus
#1
Alexander N Lukashev, Alexander S Klimentov, Svetlana E Smirnova, Tamara K Dzagurova, Jan Felix Drexler, Anatoly P Gmyl
Crimean Congo hemorrhagic fever virus (CCHFV) is one of the most severe viral zoonozes. It is prevalent throughout Africa, Asia and southern Europe. Limited availability of sequence data has hindered phylogeographic studies. The complete genomic sequence of all three segments of 14 Crimean Congo hemorrhagic fever virus strains isolated from 1958-2000 in Russia, Central Asia and Africa was identified. Each genomic segment was independently subjected to continuous Bayesian phylogeographic analysis. The origin of each genomic segment was traced to Africa about 1,000-5,000 years ago...
2016: PloS One
https://www.readbyqxmd.com/read/27788062/detection-of-leishmania-infantum-and-a-novel-phlebovirus-balkan-virus-from-sand-flies-in-albania
#2
Nazli Ayhan, Enkelejda Velo, Xavier de Lamballerie, Majlinda Kota, Perparim Kadriaj, Yusuf Ozbel, Remi N Charrel, Silvia Bino
OBJECTIVE: To organize entomological campaigns to trap sand flies in selected regions of Albania and to test them for the presence of existing or new phleboviruses and for leishmania DNA. METHODS: Sand flies were collected in 14 locations from May to October 2014 using three different types of traps. Pools with a maximum of 30 individuals were prepared according to gender, trapping site, and trapping date; they were tested for the presence of (1) phlebovirus RNA with three different PCR systems (2) and Leishmania DNA using two different real-time PCR assays...
December 2016: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/27667586/biosafety-standards-for-working-with-crimean-congo-hemorrhagic-fever-virus
#3
Manfred Weidmann, Tatjana Avsic-Zupanc, Silvia Bino, Michelle Bouloy, Felicity Burt, Sadegh Chinikar, Iva Christova, Isuf Dedushaj, Ahmed El-Sanousi, Nazif Elaldi, Roger Hewson, Frank T Hufert, Isme Humolli, Petrus Jansen van Vuren, Zeliha Koçak Tufan, Gülay Korukluoglu, Pieter Lyssen, Ali Mirazimi, Johan Neyts, Matthias Niedrig, Aykut Ozkul, Anna Papa, Janusz Paweska, Amadou A Sall, Connie S Schmaljohn, Robert Swanepoel, Yavuz Uyar, Friedemann Weber, Herve Zeller
In countries from which Crimean-Congo haemorrhagic fever (CCHF) is absent, the causative virus, CCHF virus (CCHFV), is classified as a hazard group 4 agent and handled in containment level (CL)-4. In contrast, most endemic countries out of necessity have had to perform diagnostic tests under biosafety level (BSL)-2 or -3 conditions. In particular, Turkey and several of the Balkan countries have safely processed more than 100 000 samples over many years in BSL-2 laboratories. It is therefore advocated that biosafety requirements for CCHF diagnostic procedures should be revised, to allow the tests required to be performed under enhanced BSL-2 conditions with appropriate biosafety laboratory equipment and personal protective equipment used according to standardized protocols in the countries affected...
November 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27538407/balkan-endemic-nephropathy-an-update-on-its-aetiology
#4
Marie Stiborová, Volker M Arlt, Heinz H Schmeiser
Balkan endemic nephropathy (BEN) is a unique, chronic renal disease frequently associated with upper urothelial cancer (UUC). It only affects residents of specific farming villages located along tributaries of the Danube River in Bosnia-Herzegovina, Croatia, Macedonia, Serbia, Bulgaria, and Romania where it is estimated that ~100,000 individuals are at risk of BEN, while ~25,000 have the disease. This review summarises current findings on the aetiology of BEN. Over the last 50 years, several hypotheses on the cause of BEN have been formulated, including mycotoxins, heavy metals, viruses, and trace-element insufficiencies...
November 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/27219907/hepatitis-a-immunity-and-region-of-origin-in-a-swiss-prison
#5
Laurent Getaz, Alejandra Casillas, Sandrine Motamed, Jean-Michel Gaspoz, Francois Chappuis, Hans Wolff
Purpose - The environmental and demographic characteristics of closed institutions, particularly prisons, precipitate morbidity during hepatitis A virus (HAV) outbreaks. Given the high prevalence of chronic liver disease and other risk factors in the prison setting, the purpose of this paper is to examine HAV-immunity and its associated factors in this population. Design/methodology/approach - The cross-sectional study was conducted in 2009: a serology screening for HAV IgG was carried out among 116 inmates in Switzerland's largest pre-trial prison...
June 13, 2016: International Journal of Prisoner Health
https://www.readbyqxmd.com/read/27184639/are-serum-quantitative-hepatitis-b-surface-antigen-levels-liver-histopathology-and-viral-loads-related-in-chronic-hepatitis-b-infected-patients
#6
Ayhan Balkan, Mustafa Namiduru, Yasemin Balkan, Ayse Ozlem Mete, Ilkay Karaoglan, Vuslat Kecik Bosnak
BACKGROUND/AIMS: Fluctuations in hepatitis B virus (HBV) DNA and alanine transaminase (ALT) levels complicate assessment of the phases of chronic hepatitis B (CHB) infection and correct identification of the inactive HBV carrier state. In this study, we aimed to examine the role of HBsAg quantification (qHBsAg) in the identification of the phases of HBV and to evaluate its association with liver histopathology. PATIENTS AND METHODS: Inactive HBV carriers (IC) (n = 104) and CHB patients (n = 100) were enrolled in the study...
May 2016: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/26800777/detection-of-puumala-virus-in-the-tissue-of-infected-naturally-rodent-hosts-in-the-area-of-central-dinarides
#7
Edina Dervović, Mirsada Hukić
Hantaviruses are the causative agents of haemorrhagic fever with renal syndrome (HFRS) in Euroasia and of hantavirus cardiopulmonary syndrome (HCPS) in the North, Central and South America. HFRS is endemic in the Balkan Peninsula, where sporadic cases or outbreaks have been reported. Puumala virus (PUUV) is the causative agent of nephropathia epidemica (NE), a mild form of HFRS. PUUV is carried by the bank voles (Myodes glareolus). In this study, we investigated viral RNA from 76 tissues samples (lung n=30, heart n=6, liver n=18 and kidney n=22) of infected naturally rodent hosts in the area of Central Dinarides caught in live traps...
April 2016: Journal of Virological Methods
https://www.readbyqxmd.com/read/26717483/spatio-temporal-identification-of-areas-suitable-for-west-nile-disease-in-the-mediterranean-basin-and-central-europe
#8
Annamaria Conte, Luca Candeloro, Carla Ippoliti, Federica Monaco, Fabrizio De Massis, Rossana Bruno, Daria Di Sabatino, Maria Luisa Danzetta, Abdennasser Benjelloun, Bouchra Belkadi, Mehdi El Harrak, Silvia Declich, Caterina Rizzo, Salah Hammami, Thameur Ben Hassine, Paolo Calistri, Giovanni Savini
West Nile virus (WNV) is a mosquito-transmitted Flavivirus belonging to the Japanese encephalitis antigenic complex of the Flaviviridae family. Its spread in the Mediterranean basin and the Balkans poses a significant risk to human health and forces public health officials to constantly monitor the virus transmission to ensure prompt application of preventive measures. In this context, predictive tools indicating the areas and periods at major risk of WNV transmission are of paramount importance. Spatial analysis approaches, which use environmental and climatic variables to find suitable habitats for WNV spread, can enhance predictive techniques...
2015: PloS One
https://www.readbyqxmd.com/read/26209519/molecular-epidemiology-and-phylogenetic-analysis-of-hepatitis-b-virus-in-a-group-of-migrants-in-italy
#9
Umbertina Villano, Alessandra Lo Presti, Michele Equestre, Eleonora Cella, Giulio Pisani, Marta Giovanetti, Roberto Bruni, Elena Tritarelli, Massimo Amicosante, Alba Grifoni, Carmelo Scarcella, Issa El-Hamad, Maria Chiara Pezzoli, Silvia Angeletti, Angeletti Silvia, Anna Rita Ciccaglione, Massimo Ciccozzi
BACKGROUND: Hepatitis B virus infection (HBV) is widespread and it is considered a major health problem worldwide. The global distribution of HBV varies significantly between countries and between regions of the world. Among the many factors contributing to the changing epidemiology of viral hepatitis, the movement of people within and between countries is a potentially important one. In Italy, the number of migrant individuals has been increasing during the past 25 years. HBV genotype D has been found throughout the world, although its highest prevalence is in the Mediterranean area, the Middle East and southern Asia...
2015: BMC Infectious Diseases
https://www.readbyqxmd.com/read/26019541/seroprevalance-of-crimean-congo-haemorrhagic-fever-in-bulgarian-livestock
#10
Robert Barthel, Emad Mohareb, Rasha Younan, Teodora Gladnishka, Nikolay Kalvatchev, Abdel Moemen, Sameh S Mansour, Cynthia Rossi, Randal Schoepp, Iva Christova
Crimean-Congo haemorrhagic fever (CCHF) is a tick-borne zoonotic disease. Over the past decade, CCHF cases in humans have emerged in Turkey and reemerged in the Balkan countries, Ukraine and Tajikistan. Occupational contact with infected livestock has been recognized as a common cause of the disease. A cross-sectional seroprevalence study in livestock was conducted in farming communities of an endemic area in Bulgaria, southeastern Europe. Overall, 72% of the tested animals were positive for IgG antibodies to CCHF virus...
May 4, 2014: Biotechnology, Biotechnological Equipment
https://www.readbyqxmd.com/read/25760444/immunization-of-knock-out-%C3%AE-%C3%AE-interferon-receptor-mice-against-high-lethal-dose-of-crimean-congo-hemorrhagic-fever-virus-with-a-cell-culture-based-vaccine
#11
Nurettin Canakoglu, Engin Berber, Sukru Tonbak, Mustafa Ertek, Ibrahim Sozdutmaz, Munir Aktas, Ahmet Kalkan, Aykut Ozdarendeli
Crimean-Congo hemorrhagic fever (CCHF) is an acute tick-borne zoonotic disease. The disease has been reported in many countries of Africa, Asia, the Middle East, and in Eurasia. During the past decade, new foci of CCHF have emerged in the Balkan Peninsula, southwest Russia, the Middle East, western China, India, Africa, and Turkey. CCHF virus produces severe hemorrhagic manifestations in humans with fatality rates up to 30%. Vaccine development efforts have been significantly hampered by a lack of animal models and therefore, no protective vaccine has been achieved...
March 2015: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/25712706/hepatitis-b-virus-genotype-and-subgenotype-prevalence-and-distribution-in-montenegro
#12
Zoran Vratnica, Gianguglielmo Zehender, Erika Ebranati, Chiara Sorrentino, Alessia Lai, Danijela Vujošević, Carla Veo, Alessandra Lo Presti, Eleonora Cella, Marta Giovanetti, Dragan Laušević, Massimo Galli, Massimo Ciccozzi, Boban Mugoša
The Mediterranean area and the Balkans in particular show the highest level of genetic heterogeneity of HBV in Europe. Data about the circulation of HBV genotypes in Montenegro are lacking. It was studied the prevalence and distribution of HBV genot/subgenotypes in a total of 150 HBV infected patients living in Montenegro. Phylogenetic analysis of 136 successfully amplified P sequences showed a high degree of genetic heterogeneity of HBV in Montenegro. Subgenotype D2 (36.8%) and D3 (32.3%) were the most prevalent, followed by genotype A (subgenotype A2 in all of the cases-19...
May 2015: Journal of Medical Virology
https://www.readbyqxmd.com/read/25538937/emergence-of-west-nile-virus-lineage-2-in-europe-a-review-on-the-introduction-and-spread-of-a-mosquito-borne-disease
#13
REVIEW
Luis M Hernández-Triana, Claire L Jeffries, Karen L Mansfield, George Carnell, Anthony R Fooks, Nicholas Johnson
West Nile virus (WNV) is transmitted by mosquitoes and causes fever and encephalitis in humans, equines, and occasionally wild birds. The virus was first isolated in sub-Saharan Africa where it is endemic. WNV lineage 1 has been responsible for repeated disease outbreaks in the countries of the Mediterranean basin over the past 50 years. This lineage was also introduced into North America in 1999 causing widespread human, equine, and avian mortality. WNV lineage 2, the first WNV lineage to be isolated, was believed to be restricted to sub-Saharan Africa causing a relatively mild fever in humans...
2014: Frontiers in Public Health
https://www.readbyqxmd.com/read/25521059/detection-of-dobrava-hantavirus-rna-in-apodemus-mice-in-bulgaria
#14
Iva Christova, Angelina Plyusnina, Teodora Gladnishka, Nikolay Kalvatchev, Iva Trifonova, Hristo Dimitrov, Vesela Mitkovska, Emad Mohareb, Alexander Plyusnin
Several Hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) in Europe: Dobrava-Belgrade virus (DOBV), Puumala, Saaremaa, Sochi, and Seoul virus. Although HFRS is endemic in Bulgaria, genome sequences of hantaviruses have never been detected in wild rodents. To identify rodent reservoirs, a total of 691 rodents from three endemic regions were trapped in 2011-2012 and screened by TaqMan RT-PCR for detection of hantaviral genomic RNA. Partial small (S) and/or large (L)-segment sequences were recovered from six Apodemus mice: five of the species A...
February 2015: Journal of Medical Virology
https://www.readbyqxmd.com/read/25037178/epidemiology-of-hbv-subgenotypes-d
#15
REVIEW
Resat Ozaras, Ilker Inanc Balkan, Mucahit Yemisen, Fehmi Tabak
The natural history of hepatitis B virus infection is not uniform and affected from several factors including, HBV genotype. Genotype D is a widely distributed genotype. Among genotype D, several subgenotypes differentiate epidemiologically and probably clinically. D1 is predominant in Middle East and North Africa, and characterized by early HBeAg seroconversion and low viral load. D2 is seen in Albania, Turkey, Brazil, western India, Lebanon, and Serbia. D3 was reported from Serbia, western India, and Indonesia...
February 2015: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/24954501/evaluating-weight-of-evidence-in-the-mystery-of-balkan-endemic-nephropathy
#16
Travis Bui-Klimke, Felicia Wu
Balkan endemic nephropathy (BEN) is a chronic, progressive wasting disease of the kidneys, endemic in certain rural regions of the Balkan nations Croatia, Serbia, Bulgaria, and Romania. It is irreversible and ultimately fatal. Though this disease was first described in the 1950s, its causes have been a mystery and a source of much academic and clinical contention. Possible etiologic agents that have been explored include exposure to metals and metalloids, viruses and bacteria, and the dietary toxins aristolochic acid (AA) and ochratoxin A (OTA)...
September 2014: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/24916721/multilocus-sequence-analysis-of-candidatus-phytoplasma-asteris-strain-and-the-genome-analysis-of-turnip-mosaic-virus-co-infecting-oilseed-rape
#17
M Seruga Musić, H Duc Nguyen, S Cerni, Ð Mamula, K Ohshima, D Skorić
AIM: Molecular characterization of a pathogenic complex infecting winter oilseed rape (Brassica napus ssp. oleifera (DC.) Metzg.) plants showing typical rape phyllody symptoms along with some atypical changes. METHODS AND RESULTS: Phytoplasma ('Candidatus Phytoplasma') presence was confirmed by PCR-RFLP and 16S rRNA gene sequencing. Phylogenetic analyses of phytoplasma amp, tufB, secY, groEL and ribosomal protein genes confirmed its affiliation to the 'Ca. P. asteris' species...
September 2014: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/24916566/predictors-of-fatality-in-pandemic-influenza-a-h1n1-virus-infection-among-adults
#18
MULTICENTER STUDY
Önder Ergönül, Servet Alan, Öznur Ak, Fatman Sargın, Arzu Kantürk, Alper Gündüz, Derya Engin, Oral Öncül, Ilker Inanc Balkan, Bahadir Ceylan, Nur Benzonana, Saadet Yazıcı, Funda Şimşek, Nuray Uzun, Asuman Inan, Eren Gulhan, Meral Ciblak, Kenan Midilli, Mustafa Ozyurt, Selim Badur, Serap Gencer, Ozcan Nazlıcan, Serdar Özer, Nail Özgüneş, Taner Yıldırmak, Turan Aslan, Pasa Göktaş, Nese Saltoğlu, Muzaffer Fincancı, Ali Ihsan Dokucu, Haluk Eraksoy
BACKGROUND: The fatality attributed to pandemic influenza A H1N1 was not clear in the literature. We described the predictors for fatality related to pandemic influenza A H1N1 infection among hospitalized adult patients. METHODS: This is a multicenter study performed during the pandemic influenza A H1N1 [A(H1N1)pdm09] outbreak which occurred in 2009 and 2010. Analysis was performed among laboratory confirmed patients. Multivariate analysis was performed for the predictors of fatality...
2014: BMC Infectious Diseases
https://www.readbyqxmd.com/read/24867363/genetic-analysis-of-dobrava-belgrade-virus-from-western-serbia-a-newly-detected-focus-in-the-balkan-peninsula
#19
G Stamenković, V Nikolić, J Blagojević, V Bugarski-Stanojević, T Adnađević, M Stanojević, M Vujošević
Dobrava-Belgrade virus (DOBV) is a hantavirus species that causes the most severe form of haemorrhagic fever with renal syndrome (HFRS) in Europe. DOBV has been detected in three Apodemus rodents: A. flavicollis, A. agrarius and A. ponticus. These emerging viruses appear throughout the Balkan Peninsula including Serbia as its central part. In this study, we examined the seroprevalence, molecular epidemiology and phylogenetics of DOBV from A. flavicollis captured at six Serbian localities. Furthermore, we applied microsatellite typing of host animal genome to analyse the role of host kinship in DOBV animal transmission...
March 2015: Zoonoses and Public Health
https://www.readbyqxmd.com/read/24789652/the-features-of-infectious-diseases-departments-and-anti-infective-practices-in-france-and-turkey-a-cross-sectional-study
#20
H Erdem, J P Stahl, A Inan, S Kilic, M Akova, C Rioux, I Pierre, A Canestri, E Haustraete, D O Engin, E Parlak, X Argemi, D Bruley, E Alp, S Greffe, S Hosoglu, S Patrat-Delon, Y Heper, M Tasbakan, V Corbin, M Hopoglu, I I Balkan, B Mutlu, E Demonchy, H Yilmaz, C Fourcade, L Toko-Tchuindzie, S Kaya, A Engin, A Yalci, C Bernigaud, H Vahaboglu, E Curlier, D Akduman, A Barrelet, S Oncu, V Korten, G Usluer, H Turgut, A Sener, O Evirgen, N Elaldi, L Gorenek
The aim of this study was to assess the infectious diseases (ID) wards of tertiary hospitals in France and Turkey for technical capacity, infection control, characteristics of patients, infections, infecting organisms, and therapeutic approaches. This cross-sectional study was carried out on a single day on one of the weekdays of June 17-21, 2013. Overall, 36 ID departments from Turkey (n = 21) and France (n = 15) were involved. On the study day, 273 patients were hospitalized in Turkish and 324 patients were followed in French ID departments...
September 2014: European Journal of Clinical Microbiology & Infectious Diseases
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