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Temporal bone carcinoma

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https://www.readbyqxmd.com/read/27591068/triple-orbital-metastases-from-prostate-cancer
#1
Kagan Tun, Turgay Bulut
Prostate carcinoma, when metastatic, typically involves bone and produces both osteoblastic and osteolytic changes. A 73-year-old man was admitted to our department because of unilateral progressive proptosis and visual blurriness for 3 months. The patient had a history of prostate adenocarcinoma diagnosis 5 years ago. We report a case of orbital involvement presented that intraorbital mass (including periocular structures), temporal bone and temporal muscle from prostate cancer. The mass was removed with total excision...
2016: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/27488595/expression-of-p53-p16-cyclin-d1-epidermal-growth-factor-receptor-and-notch1-in-patients-with-temporal-bone-squamous-cell-carcinoma
#2
Shinya Morita, Yuji Nakamaru, Akihiro Homma, Shinichiro Yasukawa, Hiromitsu Hatakeyama, Tomohiro Sakashita, Satoshi Kano, Atsushi Fukuda, Satoshi Fukuda
BACKGROUND: The aim of this study was to investigate the expression of p53, p16, cyclin D1, epidermal growth factor receptor (EGFR) and Notch1 in temporal bone squamous cell carcinoma (TBSCC) tissue samples by immunohistochemistry (IHC), and to evaluate the association between these biomarkers and clinicopathological features. METHODS: We performed a retrospective, single-institution review of 30 TBSCC patients treated with curative intent between April 2006 and March 2015...
August 3, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27466887/the-outcomes-of-surgery-and-chemoradiotherapy-for-temporal-bone-cancer
#3
Shinya Morita, Akihiro Homma, Yuji Nakamaru, Tomohiro Sakashita, Hiromitsu Hatakeyama, Satoshi Kano, Atsushi Fukuda, Satoshi Fukuda
OBJECTIVE: We aimed to evaluate the prognostic factors and efficacy of treatment modalities for patients with temporal bone cancer, and to determine if definitive chemoradiotherapy (CRT) for advanced-stage disease can provide a substitute for highly invasive surgeries. STUDY DESIGN: Retrospective case series. SETTING: Tertiary referral center. PATIENTS: Sixty-six patients with previously untreated squamous cell carcinoma of the temporal bone treated with curative intent between April 1997 and March 2015...
September 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27403358/lesion-in-scalp-and-skull-as-the-first-manifestation-of-hepatocellular-carcinoma
#4
V R Ferraz, J L Vitorino-Araújo, L Sementilli, J F Neto, J C E Veiga
Hepatocellular carcinoma (HCC) is the most common primary tumor of the liver and the fifth most common cancer in the world. The lungs, bone, and lymph nodes are frequent sites of metastasis of HCC. The purpose of the present study is show that metastases, although rare, must be among the differential diagnosis of skin lesions and that a diagnostic research based on these findings can be conducted. The authors report a rare case of metastatic hepatocellular injury to the scalp and skull treated by a radical surgical approach...
2016: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/27350919/microangiopathic-hemolytic-anemia-associated-with-metastatic-breast-cancer-case-report-and-literature-review
#5
Daisuke Takabatake, Kazuyuki Oishi
INTRODUCTION: Microangiopathic hemolytic anemia (MAHA) is a mechanical hemolytic anemia characterized by the emergence of fragmented red cells in peripheral blood. Here, we report a case of breast cancer associated with cancer-related (CR)-MAHA along with a literature review. CASE DESCRIPTION: The patient was a 54-year-old woman who made an emergency visit to our hospital because of low back pain, shoulder pain, visual impairment, and anemia. She was diagnosed with stage IV, ER-positive, PgR-positive, HER2-negative left breast cancer (invasive lobular carcinoma), with left axillary adenopathy, metastasis to the soft tissue of the orbital region, multiple bone metastases, pleural dissemination, and metastasis to the stomach and para-aortic lymph nodes...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27330424/temporal-bone-carcinoma-classical-prognostic-variables-revisited-and-modern-clinico-pathological-evidence
#6
Elisabetta Zanoletti, Gino Marioni, Sebastiano Franchella, Sara Munari, Roberto Pareschi, Antonio Mazzoni, Alessandro Martini
AIM: Prognostic factors, rational management, and the ongoing investigations regarding temporal bone squamous cell carcinoma (TBSCC) have been critically reviewed. BACKGROUND: TBSCC is an uncommon, aggressive malignancy. Although some progress has been made in treating this aggressive tumor, the prognosis in advanced cases remains poor. MATERIALS AND METHODS: A systematic search of the literature for articles published between 2009 and October 2014 was performed using the PubMed (http://www...
July 2016: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/27312487/osteopontin-expression-in-co-cultures-of-human-squamous-cell-carcinoma-derived-cells-and-osteoblastic-cells-and-its-effects-on-the-neoplastic-cell-phenotype-and-osteoclastic-activation
#7
Lucas Novaes Teixeira, Larissa Moreira Spinola de Castro Raucci, Gabriela Caroline Alonso, Ricardo Della Coletta, Adalberto Luiz Rosa, Paulo Tambasco de Oliveira
This study evaluated the temporal expression of osteopontin (OPN) in co-cultures of human osteoblastic cells (SAOS-2) and oral squamous cell carcinoma (OSCC)-derived cells (SCC9) and examined the effects of osteoblast-derived OPN on the neoplastic cell phenotype. Additionally, the effects of these co-cultures on subsequent osteoclastic activity were explored. SCC9 cells were plated on Transwell® membranes that were either coated or not coated with Matrigel and were then co-cultured with SAOS-2 cells during the peak of OPN expression...
June 16, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27241556/efficacy-of-petrosectomy-in-malignant-invasion-of-the-temporal-bone
#8
M Wierzbicka, T Kopeć, W Szyfter, A Buczkowska, Ł Borucki
We present the outcomes of lateral, subtotal, and total petrosectomies in patients with invasion of the temporal bone by specific primary cancers, with particular emphasis on survival in the advanced stages of disease. We made a retrospective study of 20 consecutive patients (squamous cell carcinoma of the temporal bone, n=11, and primary cancer of the parotid gland with infiltration of the lateral skull base, n=9) treated by total, subtotal, or lateral petrosectomy at the University Department of Otolaryngology, a tertiary referral centre, between June 2006 and December 2010...
September 2016: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/27067586/aggressive-basal-cell-carcinoma-of-the-head-and-neck-challenges-in-surgical-management
#9
Peter J F M Lohuis, Anil Joshi, Pepijn A Borggreven, Lenka Vermeeren, Biljana Zupan-Kajcovski, Abrahim Al-Mamgani, Alfons J M Balm
With exponentially increasing numbers of basal cell carcinoma (BCC) of the head and neck region, also the locally advanced BCCs are increasing in number. These tumours are associated with aggressive biological behaviour with invasion of soft tissues, organs or bone and present with wide variation in management strategies. The objectives of the study was to describe the biological behaviour of aggressive BCCs and their clinical presentation in the head and neck region with a series of cases treated in our tertiary hospital, discuss management plans of such complex cases in terms of surgical planning and reconstruction...
April 11, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/26988214/temporal-bone-squamous-cell-carcinoma-penang-experience
#10
S Y Ng, K C Pua, Z Zahirrudin
Temporal bone squamous cell carcinoma (TBSCC) is rare and poses difficulties in diagnosing, staging and management. We describe a case series with six patients who were diagnosed TBSCC, from January 2009 to June 2014, with median age of 62 years old. All patients presented with blood-stain discharge and external auditory canal mass, showing that these findings should highly alert the diagnosis of TBSCC. Three patients staged T3 and another three with T4 disease. High-resolution CT (HRCT) temporal findings were noted to be different from intraoperative findings and therefore we conclude that MRI should be done to look for middle ear involvement or other soft tissue invasion for more accurate staging...
December 2015: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/26980913/reconstruction-of-lateral-skull-base-defects-a-comparison-of-the-submental-flap-to-free-and-regional-flaps
#11
Brittany E Howard, Thomas H Nagel, David M Barrs, Carrlene B Donald, Richard E Hayden
OBJECTIVES: To compare reconstructive techniques, operative times, duration of hospitalization, and need for subsequent flap revisions between reconstructive approaches to lateral skull base defects. STUDY DESIGN: Case series with chart review. SETTING: Tertiary academic referral center. SUBJECTS: Patients (n = 31) undergoing reconstruction of composite lateral skull base defects from 2002 to 2014. METHODS: Data were analyzed for demographics, tumor characteristics, reconstructive technique, operative time, duration of hospitalization, complications, and outcomes...
June 2016: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/26901495/photoactivated-inhibition-of-cathepsin-k-in-a-3d-tumor-model
#12
Mackenzie K Herroon, Rajgopal Sharma, Erandi Rajagurubandara, Claudia Turro, Jeremy J Kodanko, Izabela Podgorski
Collagenolytic activity of cathepsin K is important for many physiological and pathological processes including osteoclast-mediated bone degradation, macrophage function and fibroblast-mediated matrix remodeling. Here, we report application of a light-activated inhibitor for controlling activity of cathepsin K in a 3D functional imaging assay. Using prostate carcinoma cell line engineered to overexpress cathepsin K, we demonstrate the utility of the proteolytic assay in living tumor spheroids for the evaluation and quantification of the inhibitor effects on cathepsin K-mediated collagen I degradation...
June 1, 2016: Biological Chemistry
https://www.readbyqxmd.com/read/26855526/neoadjuvant-chemotherapy-in-technically-unresectable-carcinoma-of-external-auditory-canal
#13
Amit Joshi, Nidhi Tandon, Vanita Noronha, Sachin Dhumal, Vijay Patil, Supreeta Arya, Shashikant Juvekar, Jaiprakash Agarwal, Anil DCruz, Prathmesh Pai, Kumar Prabhash
BACKGROUND: Carcinoma of external auditory canal (EAC) is a very rare malignancy with surgical resection as the main modality of treatment. The outcomes with nonsurgical modalities are very dismal. We present a retrospective analysis of 4 patients evaluating the role of neoadjuvant chemotherapy in technically unresectable cancers. MATERIALS AND METHODS: This is a retrospective analysis of 4 patients from our institute from 2010 to 2014 with carcinoma EAC who were deemed unfit for surgery due to extensive disease involving occipital bone with soft tissue infiltration (n = 2), temporal dura (n = 1), left temporal lobe, and extensive soft tissue involvement (n = 1)...
July 2015: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/26832631/malignant-tumors-of-the-temporal-bone-our-experience
#14
Ana Pereira da Silva, Eduardo Breda, Eurico Monteiro
INTRODUCTION: Malignant tumors of the temporal bone are rare, with an estimated incidence of about 0.8-1.0 per 1,000,000 inhabitants per year. The vast majority of these tumors are squamous cell carcinomas and their treatment is eminently surgical. OBJECTIVE: This study is an attempt at systematizing the forms of clinical presentation, the therapeutic possibilities, and oncological outcomes of patients with malignant tumors of the temporal bone in a tertiary hospital in Portugal...
July 2016: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/26825921/bulbar-paralysis-and-facial-paralysis-due-to-metastatic-hepatocellular-carcinoma-a-case-report-and-literature-review
#15
REVIEW
Min Liu, Shixin Liu, Bailong Liu, Bin Liu, Liang Guo, Xu Wang, Qiang Wang, Shuo Yang, Lihua Dong
Skull-base metastasis (SBM) from hepatocellular carcinoma (HCC) is extremely rare, and multiple cranial nerve paralysis due to SBM from HCC is also rare. We report a case of bulbar and facial paralysis due to SBM from HCC. A 46-year-old Chinese man presented with a hepatic right lobe lesion that was detected during a routine physical examination. After several failed attempts to treat the primary tumor and bone metastases, neurological examination revealed left VII, IX, X, and XI cranial nerve paralysis. Computed tomography of the skull base subsequently revealed a large mass that had destroyed the left occipital and temporal bones and invaded the adjacent structure...
January 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26824405/en-bloc-temporal-bone-resections-in-squamous-cell-carcinoma-of-the-ear-technique-principles-and-limits
#16
Antonio Mazzoni, Elisabetta Zanoletti, Gino Marioni, Alessandro Martini
CONCLUSIONS: En bloc resection should always be primarily considered in ear carcinoma, also in advanced tumors growing beyond the walls of the external auditory canal, because it achieves a full specimen for histopathological evaluation and allows a correlation between clinical, pathological features, and outcomes. OBJECTIVE AND METHODS: Dismal outcome of surgical and radiotherapic therapies for advanced ear carcinoma required a critical discussion of the oncological principles of treatment...
2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/26794337/post-radiotherapy-bilateral-external-auditory-canal-cholesteatoma
#17
Emrah Sapmaz, Battal Tahsin Somuk, Harun Soyalıç, Can Koçak, Erkan Gökçe
In this article, we report a 55-year-old female case was treated with radiotherapy due to nasopharynx carcinoma and diagnosed with bilateral external auditory canal cholesteatoma four years after radiotherapy. Persistent otorrhea was present in the patient and the diagnosis was established through noticing a soft tissue mass eroding external auditory canal anterior wall in temporal bone tomography as well as the otoscopic findings. Canaloplasty and cholesteatoma excision were administered as the surgical treatment...
2016: Kulak Burun Boğaz Ihtisas Dergisi: KBB, Journal of Ear, Nose, and Throat
https://www.readbyqxmd.com/read/26788355/intramastoid-solitary-neurofibroma-mimicking-middle-ear-carcinoma
#18
Zhenshan Shi, Qian Zhuang, Dairong Cao
We report an extremely rare case of intramastoid neurofibroma. A mass with destruction of the mastoid bone of a 51-year-old woman was examined with computed tomography. Subsequent magnetic resonance imaging demonstrated an ill-defined soft tissue mass with the opacification of mastoid air cells that had a mass effect in the same area. The patient underwent left subtotal temporal bone resection, and histological and immunohistochemical findings confirmed the lesion to be a neurofibroma. Given that similar imaging features of neurofibroma have been reported previously elsewhere in the head/neck and extremities, we suggest that it may be possible to include this tumor in the preoperative differential diagnosis...
December 2015: Acta Radiologica Open
https://www.readbyqxmd.com/read/26665451/-diagnosis-and-treatment-of-rare-malignant-tumors-in-external-auditory-canal
#19
Fangyuan Wang, Nan Wu, Zhaohui Hou, Jun Liu, Weidong Shen, Weiju Han, Shiming Yang
OBJECTIVE: To analyze the diagnosis, therapy and prognosis of the rare cases of malignant tumors in external auditory canal. METHOD: Eight cases of rare malignant tumors in external auditory canal were collected except squamous cell carcinoma and adenoid cystic carcinoma. The clinical manifestation, staging, surgical method, secondary treatment and prognosis were analysed. RESULT: There were 5 cases of basal cell carcinoma and 2 cases of mucoepidermoid carcinoma and 1 case of myoepithelial carcinoma...
August 2015: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/26549119/a-critical-look-at-persistent-problems-in-the-diagnosis-staging-and-treatment-of-temporal-bone-carcinoma
#20
REVIEW
Elisabetta Zanoletti, Andrea Lovato, Paola Stritoni, Alessandro Martini, Antonio Mazzoni, Gino Marioni
Temporal bone squamous cell carcinoma (TBSCC) is an uncommon malignancy with a distinctly poor prognosis in advanced cases. There is still much controversy surrounding the rational diagnostic/therapeutic approach to TBSCC. Diagnostic differences are due mainly to: the small number of cases reported (even in the largest available series); the inappropriate histological heterogeneity of several case series; the lack of an internationally-accepted staging system for TBSCC; the frequent absence of adequate radiological imaging to enable a malignancy's local, regional and distant extension to be studied in detail; and a non-standardized approach to final histological assessment of the surgical margins...
December 2015: Cancer Treatment Reviews
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