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Temporal bone carcinoma

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https://www.readbyqxmd.com/read/28326215/osteoradionecrosis-of-the-temporal-bone-leading-to-cerebellar-abscess
#1
Thomas B Layton
Squamous cell carcinoma of the temporal bone is a rare and destructive malignancy and represents both diagnostic and therapeutic challenge. The complex regional anatomy of the temporal bone requires equally intricate surgical techniques to adequately resect the tumour mass during surgical excision. Adjuvant radiotherapy is offered to patients with advanced disease and has been showed to confer a survival benefit in carefully selected patients. One feared complication of radiotherapy is osteoradionecrosis and is a major obstacle faced in the treatment of head and neck cancers...
2017: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/28180041/update-on-surgical-outcomes-of-lateral-temporal-bone-resection-for-ear-and-temporal-bone-malignancies
#2
Sumi Sinha, Matthew M Dedmon, Matthew R Naunheim, Jennifer C Fuller, Stacey T Gray, Derrick T Lin
Objectives Review outcomes of lateral temporal bone resections for ear and temporal bone malignancy. Design, Setting, and Participants Retrospective review of all lateral temporal bone resections performed from 2008 to 2015 at a single tertiary care center. Main Outcome Measures Patient demographics, perioperative variables, overall survival, disease-free survival (DFS), and comparison of Kaplan-Meier curves. Results Overall, 56 patients were identified with a mean follow-up period of 2.3 ± 1.8 years...
February 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28141179/pedicled-temporalis-muscle-flap-stuffing-after-a-lateral-temporal-bone-resection-for-treating-mastoid-osteoradionecrosis
#3
Junming Chen, Feng Lin, Zhen Liu, Youjun Yu, Yuejian Wang
Objective The aim of this study was to compare the outcomes of lateral temporal bone resection and pedicled temporalis muscle flap stuffing with external auditory canal closure with those of canal wall down mastoidectomy for the treatment of mastoid osteoradionecrosis. Study Design Prospective nonrandomized case-control clinical study. Setting Department of Otolaryngology of the First People's Hospital of Foshan. Subjects and Methods Seventy-seven postirradiation nasopharyngeal carcinoma patients with mastoid osteoradionecrosis were included...
April 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28131549/cortactin-and-phosphorylated-cortactin-tyr-466-expression-in-temporal-bone-carcinoma
#4
Gino Marioni, Elisabetta Zanoletti, Antonio Mazzoni, Andrea Gianatti, Elisa Valentini, Laura Girasoli, Martina Guariento, Luciano Giacomelli, Alessandro Martini, Stella Blandamura
PURPOSE: Cortactin is a multidomain protein engaged in several cellular mechanisms involving actin assembly and cytoskeletal arrangement. Cortactin overexpression in several malignancies has been associated with increased cell migration, invasion, and metastatic potential. Cortactin needs to be activated by tyrosine or serine/threonine phosphorylation. The role of cortactin and phosphorylated cortactin (residue tyr(466)) was investigated in temporal bone squamous cell carcinoma (TBSCC)...
March 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28045729/68ga-psma-pet-ct-in-a-rare-case-of-metastatic-adenocarcinoma-prostate-presenting-as-numb-chin-syndrome
#5
Arun Sasikumar, Ajith Joy, M R A Pillai, Renuka Gopal, Boben Thomas
A 68-year-old man presented with right-side facial numbness. MRI showed an extra-axial mass infiltrating the right temporal bone. It was debulked surgically, and histopathology revealed metastatic adenocarcinoma. Ga PSMA PET/CT done in view of increased PSA levels and clinically suspicious hard lesion in prostate showed primary lesion in left side of prostate with metastases to the right temporal bone. Primary carcinoma of the prostate and metastases to the right temporal bone were proven histopathologically...
March 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28044211/survival-impact-of-local-extension-sites-in-surgically-treated-patients-with-temporal-bone-squamous-cell-carcinoma
#6
Go Omura, Mizuo Ando, Yuki Saito, Osamu Fukuoka, Ken Akashi, Masafumi Yoshida, Akinobu Kakigi, Takahiro Asakage, Tatsuya Yamasoba
OBJECTIVES: Temporal bone squamous cell carcinoma (TSCC) is a rare malignancy. Due to its low incidence rate, studies involving TSCC treatment are limited. The aim of this study is to define the prognostic factors of surgery for TSCC by evaluating our clinical experience. METHODS: We reviewed the clinical charts of patients presenting at the University of Tokyo Hospital between 2001 and 2014 and identified 33 patients with TSCC who had been treated with surgery as initial curative treatment...
January 2, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27942606/a-case-of-squamous-cell-carcinoma-in-the-external-auditory-canal-previously-treated-for-verrucous-carcinoma
#7
Soo Jung Nam, Chan Joo Yang, Jong Woo Chung
Carcinoma in the external auditory canal (EAC) is a rare malignancy with an annual incidence of one per one million people, accounting for less than 0.2% of all head and neck cancers. The most common histopathological type of EAC cancer is squamous cell carcinoma. Verrucous carcinoma is a well-differentiated, low-grade variant of squamous cell carcinoma. It is a locally destructive, invasive, and slow growing tumor that rarely metastasizes. Verrucous carcinoma occurs predominantly in the oral cavity and larynx, and its occurrence in the EAC is extremely rare...
December 2016: Journal of Audiology & Otology
https://www.readbyqxmd.com/read/27591068/triple-orbital-metastases-from-prostate-cancer
#8
Kagan Tun, Turgay Bulut
Prostate carcinoma, when metastatic, typically involves bone and produces both osteoblastic and osteolytic changes. A 73-year-old man was admitted to our department because of unilateral progressive proptosis and visual blurriness for 3 months. The patient had a history of prostate adenocarcinoma diagnosis 5 years ago. We report a case of orbital involvement presented that intraorbital mass (including periocular structures), temporal bone and temporal muscle from prostate cancer. The mass was removed with total excision...
2016: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/27488595/expression-of-p53-p16-cyclin-d1-epidermal-growth-factor-receptor-and-notch1-in-patients-with-temporal-bone-squamous-cell-carcinoma
#9
Shinya Morita, Yuji Nakamaru, Akihiro Homma, Shinichiro Yasukawa, Hiromitsu Hatakeyama, Tomohiro Sakashita, Satoshi Kano, Atsushi Fukuda, Satoshi Fukuda
BACKGROUND: The aim of this study was to investigate the expression of p53, p16, cyclin D1, epidermal growth factor receptor (EGFR) and Notch1 in temporal bone squamous cell carcinoma (TBSCC) tissue samples by immunohistochemistry (IHC), and to evaluate the association between these biomarkers and clinicopathological features. METHODS: We performed a retrospective, single-institution review of 30 TBSCC patients treated with curative intent between April 2006 and March 2015...
February 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27466887/the-outcomes-of-surgery-and-chemoradiotherapy-for-temporal-bone-cancer
#10
Shinya Morita, Akihiro Homma, Yuji Nakamaru, Tomohiro Sakashita, Hiromitsu Hatakeyama, Satoshi Kano, Atsushi Fukuda, Satoshi Fukuda
OBJECTIVE: We aimed to evaluate the prognostic factors and efficacy of treatment modalities for patients with temporal bone cancer, and to determine if definitive chemoradiotherapy (CRT) for advanced-stage disease can provide a substitute for highly invasive surgeries. STUDY DESIGN: Retrospective case series. SETTING: Tertiary referral center. PATIENTS: Sixty-six patients with previously untreated squamous cell carcinoma of the temporal bone treated with curative intent between April 1997 and March 2015...
September 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27403358/lesion-in-scalp-and-skull-as-the-first-manifestation-of-hepatocellular-carcinoma
#11
V R Ferraz, J L Vitorino-Araújo, L Sementilli, J F Neto, J C E Veiga
Hepatocellular carcinoma (HCC) is the most common primary tumor of the liver and the fifth most common cancer in the world. The lungs, bone, and lymph nodes are frequent sites of metastasis of HCC. The purpose of the present study is show that metastases, although rare, must be among the differential diagnosis of skin lesions and that a diagnostic research based on these findings can be conducted. The authors report a rare case of metastatic hepatocellular injury to the scalp and skull treated by a radical surgical approach...
2016: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/27350919/microangiopathic-hemolytic-anemia-associated-with-metastatic-breast-cancer-case-report-and-literature-review
#12
Daisuke Takabatake, Kazuyuki Oishi
INTRODUCTION: Microangiopathic hemolytic anemia (MAHA) is a mechanical hemolytic anemia characterized by the emergence of fragmented red cells in peripheral blood. Here, we report a case of breast cancer associated with cancer-related (CR)-MAHA along with a literature review. CASE DESCRIPTION: The patient was a 54-year-old woman who made an emergency visit to our hospital because of low back pain, shoulder pain, visual impairment, and anemia. She was diagnosed with stage IV, ER-positive, PgR-positive, HER2-negative left breast cancer (invasive lobular carcinoma), with left axillary adenopathy, metastasis to the soft tissue of the orbital region, multiple bone metastases, pleural dissemination, and metastasis to the stomach and para-aortic lymph nodes...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27330424/temporal-bone-carcinoma-classical-prognostic-variables-revisited-and-modern-clinico-pathological-evidence
#13
Elisabetta Zanoletti, Gino Marioni, Sebastiano Franchella, Sara Munari, Roberto Pareschi, Antonio Mazzoni, Alessandro Martini
AIM: Prognostic factors, rational management, and the ongoing investigations regarding temporal bone squamous cell carcinoma (TBSCC) have been critically reviewed. BACKGROUND: TBSCC is an uncommon, aggressive malignancy. Although some progress has been made in treating this aggressive tumor, the prognosis in advanced cases remains poor. MATERIALS AND METHODS: A systematic search of the literature for articles published between 2009 and October 2014 was performed using the PubMed (http://www...
July 2016: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/27312487/osteopontin-expression-in-co-cultures-of-human-squamous-cell-carcinoma-derived-cells-and-osteoblastic-cells-and-its-effects-on-the-neoplastic-cell-phenotype-and-osteoclastic-activation
#14
Lucas Novaes Teixeira, Larissa Moreira Spinola de Castro Raucci, Gabriela Caroline Alonso, Ricardo Della Coletta, Adalberto Luiz Rosa, Paulo Tambasco de Oliveira
This study evaluated the temporal expression of osteopontin (OPN) in co-cultures of human osteoblastic cells (SAOS-2) and oral squamous cell carcinoma (OSCC)-derived cells (SCC9) and examined the effects of osteoblast-derived OPN on the neoplastic cell phenotype. Additionally, the effects of these co-cultures on subsequent osteoclastic activity were explored. SCC9 cells were plated on Transwell® membranes that were either coated or not coated with Matrigel and were then co-cultured with SAOS-2 cells during the peak of OPN expression...
September 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27241556/efficacy-of-petrosectomy-in-malignant-invasion-of-the-temporal-bone
#15
M Wierzbicka, T Kopeć, W Szyfter, A Buczkowska, Ł Borucki
We present the outcomes of lateral, subtotal, and total petrosectomies in patients with invasion of the temporal bone by specific primary cancers, with particular emphasis on survival in the advanced stages of disease. We made a retrospective study of 20 consecutive patients (squamous cell carcinoma of the temporal bone, n=11, and primary cancer of the parotid gland with infiltration of the lateral skull base, n=9) treated by total, subtotal, or lateral petrosectomy at the University Department of Otolaryngology, a tertiary referral centre, between June 2006 and December 2010...
September 2016: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/27067586/aggressive-basal-cell-carcinoma-of-the-head-and-neck-challenges-in-surgical-management
#16
Peter J F M Lohuis, Anil Joshi, Pepijn A Borggreven, Lenka Vermeeren, Biljana Zupan-Kajcovski, Abrahim Al-Mamgani, Alfons J M Balm
With exponentially increasing numbers of basal cell carcinoma (BCC) of the head and neck region, also the locally advanced BCCs are increasing in number. These tumours are associated with aggressive biological behaviour with invasion of soft tissues, organs or bone and present with wide variation in management strategies. The objectives of the study was to describe the biological behaviour of aggressive BCCs and their clinical presentation in the head and neck region with a series of cases treated in our tertiary hospital, discuss management plans of such complex cases in terms of surgical planning and reconstruction...
November 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/26988214/temporal-bone-squamous-cell-carcinoma-penang-experience
#17
S Y Ng, K C Pua, Z Zahirrudin
Temporal bone squamous cell carcinoma (TBSCC) is rare and poses difficulties in diagnosing, staging and management. We describe a case series with six patients who were diagnosed TBSCC, from January 2009 to June 2014, with median age of 62 years old. All patients presented with blood-stain discharge and external auditory canal mass, showing that these findings should highly alert the diagnosis of TBSCC. Three patients staged T3 and another three with T4 disease. High-resolution CT (HRCT) temporal findings were noted to be different from intraoperative findings and therefore we conclude that MRI should be done to look for middle ear involvement or other soft tissue invasion for more accurate staging...
December 2015: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/26980913/reconstruction-of-lateral-skull-base-defects-a-comparison-of-the-submental-flap-to-free-and-regional-flaps
#18
Brittany E Howard, Thomas H Nagel, David M Barrs, Carrlene B Donald, Richard E Hayden
OBJECTIVES: To compare reconstructive techniques, operative times, duration of hospitalization, and need for subsequent flap revisions between reconstructive approaches to lateral skull base defects. STUDY DESIGN: Case series with chart review. SETTING: Tertiary academic referral center. SUBJECTS: Patients (n = 31) undergoing reconstruction of composite lateral skull base defects from 2002 to 2014. METHODS: Data were analyzed for demographics, tumor characteristics, reconstructive technique, operative time, duration of hospitalization, complications, and outcomes...
June 2016: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/26901495/photoactivated-inhibition-of-cathepsin-k-in-a-3d-tumor-model
#19
Mackenzie K Herroon, Rajgopal Sharma, Erandi Rajagurubandara, Claudia Turro, Jeremy J Kodanko, Izabela Podgorski
Collagenolytic activity of cathepsin K is important for many physiological and pathological processes including osteoclast-mediated bone degradation, macrophage function and fibroblast-mediated matrix remodeling. Here, we report application of a light-activated inhibitor for controlling activity of cathepsin K in a 3D functional imaging assay. Using prostate carcinoma cell line engineered to overexpress cathepsin K, we demonstrate the utility of the proteolytic assay in living tumor spheroids for the evaluation and quantification of the inhibitor effects on cathepsin K-mediated collagen I degradation...
June 1, 2016: Biological Chemistry
https://www.readbyqxmd.com/read/26855526/neoadjuvant-chemotherapy-in-technically-unresectable-carcinoma-of-external-auditory-canal
#20
Amit Joshi, Nidhi Tandon, Vanita Noronha, Sachin Dhumal, Vijay Patil, Supreeta Arya, Shashikant Juvekar, Jaiprakash Agarwal, Anil DCruz, Prathmesh Pai, Kumar Prabhash
BACKGROUND: Carcinoma of external auditory canal (EAC) is a very rare malignancy with surgical resection as the main modality of treatment. The outcomes with nonsurgical modalities are very dismal. We present a retrospective analysis of 4 patients evaluating the role of neoadjuvant chemotherapy in technically unresectable cancers. MATERIALS AND METHODS: This is a retrospective analysis of 4 patients from our institute from 2010 to 2014 with carcinoma EAC who were deemed unfit for surgery due to extensive disease involving occipital bone with soft tissue infiltration (n = 2), temporal dura (n = 1), left temporal lobe, and extensive soft tissue involvement (n = 1)...
July 2015: Indian Journal of Medical and Paediatric Oncology
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