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Surgical sealant

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https://www.readbyqxmd.com/read/28051764/the-use-of-fibrin-sealant-during-non-emergency-surgery-a-systematic-review-of-evidence-of-benefits-and-harms
#1
Steven J Edwards, Fay Crawford, Michelle Helena van Velthoven, Andrea Berardi, George Osei-Assibey, Mariana Bacelar, Fatima Salih, Victoria Wakefield
BACKGROUND: Fibrin sealants are used in different types of surgery to prevent the accumulation of post-operative fluid (seroma) or blood (haematoma) or to arrest haemorrhage (bleeding). However, there is uncertainty around the benefits and harms of fibrin sealant use. OBJECTIVES: To systematically review the evidence on the benefits and harms of fibrin sealants in non-emergency surgery in adults. DATA SOURCES: Electronic databases [MEDLINE, EMBASE and The Cochrane Library (including the Cochrane Database of Systematic Reviews, the Database of Abstracts of Reviews of Effects, the Health Technology Assessment database and the Cochrane Central Register of Controlled Trials)] were searched from inception to May 2015...
December 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28043785/tissue-sealants-may-reduce-haematoma-and-complications-in-face-lifts-a-meta-analysis-of-comparative-studies
#2
REVIEW
Salvatore Giordano, Ilkka Koskivuo, Erkki Suominen, Esko Veräjänkorva
: The use of tissue sealants has increased among different surgical specialities. Face-lift and rhytidoplasty may cause several complications such as haematoma, ecchymosis, oedema, seroma, skin necrosis, wound dehiscence and wound infection. However, administration of tissue sealants may prevent the occurrence of some complications. We performed a meta-analysis of studies that compared tissue sealant use with controls to evaluate the outcomes. A systematic literature search was performed...
December 15, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28039851/in-vitro-comparison-of-two-widely-used-surgical-sealants-for-treating-alveolar-air-leak
#3
Ruoyu Zhang, Maximilian Bures, Klaus Höffler, Danny Jonigk, Axel Haverich, Marcus Krueger
No abstract text is available yet for this article.
December 31, 2016: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/28029534/the-influence-of-fellowship-training-on-the-practice-of-pancreatoduodenectomy
#4
Gregory T Kennedy, Matthew T McMillan, Michael H Sprys, Claudio Bassi, Paul D Greig, Paul D Hansen, Dhiresh R Jeyarajah, Tara S Kent, Giuseppe Malleo, Giovanni Marchegiani, Rebecca M Minter, Charles M Vollmer
BACKGROUND: There has been a proliferation of gastrointestinal surgical fellowships; however, little is known regarding their association with surgical volume and management approaches. METHODS: Surveys were distributed to members of GI surgical societies. Responses were evaluated to define relationships between fellowship training and surgical practice with pancreatoduodenectomy (PD). RESULTS: Surveys were completed by 889 surgeons, 84.1% of whom had completed fellowship training...
October 28, 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28008551/surgical-treatment-of-large-incisional-hernias-with-intraperitoneal-composite-mesh-a-cohort-study
#5
B Lasses Martínez, M J Peña Soria, J J Cabeza Gómez, D Jiménez Valladolid, M Flores Gamarra, C Fernández Pérez, A Torres García, I Delgado Lillo
PURPOSE: Patients with large incisional hernias have significant morbidity and their management is a challenge for the surgical team because of the large abdominal wall involvement. The choice of surgical technique is still controversial. The purpose of this study is to analyze the predictive factors for recurrence after intraperitoneal mesh repair in patients with large incisional hernias. METHODS: A retrospective cohort observational study with a prospectively collected database was performed in the Hospital Clinico San Carlos (Madrid, Spain)...
December 22, 2016: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/27988916/experimental-study-of-intraparenchymal-fibrinogen-and-topical-thrombin-to-seal-pleural-defects
#6
Jun Yamamoto, Mitsutomo Kohno, Naoko Izawa, Toshinari Ema, Tai Hato, Ikuo Kamiyama, Takashi Ohtsuka, Masazumi Watanabe
OBJECTIVE: Fibrin sealants are used to close surgical pleural defects, but may detach, causing a postoperative air-leak. We investigated a new means of applying fibrin glue for closing pleural defects. METHODS: Pleural defects (10-mm and 4-mm diameters, respectively) were created in swine and rats via thoracotomy. They were sealed by a) injection of a fibrinogen solution into the lung parenchyma after instillation of a thrombin solution onto the pleural defect (group A), b) fibrinogen and thrombin spray (group B), c) fibrinogen instillation and a thrombin-dipped polyglycolic acid sheet (group C), or d) fibrin glue-coated collagen fleece (group D)...
December 20, 2016: Tokai Journal of Experimental and Clinical Medicine
https://www.readbyqxmd.com/read/27972289/a-retrospective-premier-database-study-to-evaluate-differences-between-progel%C3%A2-pleural-air-leak-sealant-as-compared-with-other-sealants-in-the-inpatient-surgical-setting
#7
K Mortman, M Corral, X Zhang, I Berhane, M Bourque, N Ferko
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27972269/economic-analysis-of-evarrest-sealant-matrix-compared-with-standard-of-care-in-severe-soft-tissue-surgical-bleeding-a-france-hospital-perspective
#8
N Jamous, T N Thanh, N Ferko, A Hogan, J Batiller, R Kocharian, W Danker Iii
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27956071/solution-blow-spun-polymer-a-novel-preclinical-surgical-sealant-for-bowel-anastomoses
#9
Nora G Kern, Adam M Behrens, Priya Srinivasan, Christopher T Rossi, John L Daristotle, Peter Kofinas, Anthony D Sandler
BACKGROUND: Solution blow spinning is a technique for depositing polymer fibers with promising potential use as a surgical sealant. This study assessed the feasibility and efficacy of solution blow spun polymer (BSP) for sealing bowel perforations in a mouse model of partial cecal transection. We then evaluated its use for reinforcing a surgical anastomosis in a preclinical piglet model. METHODS: Three commercially available surgical sealants (fibrin glue, polyethylene glycol (PEG) hydrogel, and cyanoacrylate) were compared to BSP in the ability to seal partially transected cecum in mice...
December 5, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27920230/troubleshooting-for-bleeding-in-thoracoscopic-anatomic-pulmonary-resection
#10
Hitoshi Igai, Mitsuhiro Kamiyoshihara, Takashi Ibe, Natsuko Kawatani, Fumi Osawa, Ryohei Yoshikawa
INTRODUCTION: The objective of this study was to evaluate intraoperative vessel injury and assess troubleshooting during thoracoscopic anatomic pulmonary resection. METHODS: Between April 2012 and March 2016, 240 patients underwent thoracoscopic anatomic lung resection, 26 of whom were identified as having massive bleeding intraoperatively. We analyzed the injured vessel and the hemostatic procedure employed, then compared the perioperative outcomes in patients with (n = 26) and without (n = 214) vessel injury...
December 5, 2016: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/27917665/the-potential-effect-of-biological-sealants-on-colorectal-anastomosis-healing-in-experimental-research-involving-severe-diabetes
#11
K Stergios, K Kontzoglou, V Pergialiotis, L M Korou, M Frountzas, O Lalude, N Nikiteas, D N Perrea
Colorectal anastomoses continuous to pose a significant challenge in current surgical practice. Anastomotic leakage remains one of the most frequent and dramatic complications of colorectal surgery, even in centres of high specialisation. Diabetes is a well-established independent factor which results in higher anastomotic leakage rates. Fibrin sealants have been applied in experimental and clinical studies for the prevention of anastomotic dehiscence. However, little is known regarding their impact on diabetic patients...
December 5, 2016: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/27860350/enhanced-sealing-by-hydrophobic-modification-of-alaska-pollock-derived-gelatin-based-surgical-sealants-for-the-treatment-of-pulmonary-air-leaks
#12
Ryo Mizuta, Tetsushi Taguchi
Pulmonary air leaks are medical complications of thoracic surgery for which fibrin sealant is the main treatment. In this study, innovative sealants based on hydrophobically modified Alaska pollock-derived gelatin (hm-ApGltn) and a poly(ethylene)glycol-based 4-armed cross-linker (4S-PEG) have been developed and their burst strengths have been evaluated using fresh rat lung. The developed sealants show higher lung burst strength compared with the nonmodified original ApGltn (Org-ApGltn)-based sealant and a commercial fibrin sealant...
November 15, 2016: Macromolecular Bioscience
https://www.readbyqxmd.com/read/27843896/surgical-reconstruction-of-ocular-surface-tumors-using-fibrin-sealant-tissue-adhesive
#13
Aline Roseane Queiroz de Paiva, Larissa Abreu de Azevedo Fraga, Virgínia Laura Lucas Torres
PURPOSE: To evaluate the surgical outcomes of ocular surface reconstruction in corneal-conjunctival tumors using fibrin tissue adhesive. METHODS: A prospective noncomparative study was performed between May 2013 and February 2015. Patients were submitted to routine surgical procedure for corneal-conjunctival tumor excision followed by amniotic membrane graft transplantation using fibrin tissue adhesive (Evicel®, Omrix Biopharmaceuticals Ltd., Israel). Results were assessed on the 1st, 7th, 15th and 30th postoperative days to analyze subjective complaints, adhesiveness and positioning of the graft, potential complications and recurrences...
October 2016: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27836205/effectiveness-of-cyanoacrylate-microbial-sealant-in-the-reduction-of-surgical-site-infection-in-gynecologic-oncology-procedures-a-phase-iii-single-institution-prospective-randomized-trial
#14
Eric D Thomas, Elizabeth K Nugent, Matthew C MacAllister, Katherine M Moxley, Lisa Landrum, Joan L Walker, D S McMeekin, Robert S Mannel, Gerald McGwin, Kathleen N Moore
OBJECTIVES: Surgery is a cornerstone for patients with gynecologic malignancies. Surgical site infections (SSI) remain a source of post-operative morbidity. Consequences range from escalated costs, delay in adjuvant therapy, and increased morbidity. Our primary objective was to evaluate the effectiveness of a cyanoacrylate microbial sealant (CMS) to reduce post-operative SSI following laparotomy for suspected gynecologic malignancy. METHODS: Patients were randomized using a 1:1 allocation to receive either standard skin preparation or standard preparation with CMS and stratified by BMI...
January 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/27770631/click-chemistry-improved-wet-adhesion-strength-of-mussel-inspired-citrate-based-antimicrobial-bioadhesives
#15
Jinshan Guo, Gloria B Kim, Dingying Shan, Jimin P Kim, Jianqing Hu, Wei Wang, Fawzi G Hamad, Guoying Qian, Elias B Rizk, Jian Yang
For the first time, a convenient copper-catalyzed azide-alkyne cycloaddition (CuAAC, click chemistry) was successfully introduced into injectable citrate-based mussel-inspired bioadhesives (iCMBAs, iCs) to improve both cohesive and wet adhesive strengths and elongate the degradation time, providing numerous advantages in surgical applications. The major challenge in developing such adhesives was the mutual inhibition effect between the oxidant used for crosslinking catechol groups and the Cu(II) reductant used for CuAAC, which was successfully minimized by adding a biocompatible buffering agent typically used in cell culture, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), as a copper chelating agent...
January 2017: Biomaterials
https://www.readbyqxmd.com/read/27759861/dehydrated-allogenic-human-amniotic-membrane-graft-for-conjunctival-surface-reconstruction-following-removal-of-exposed-scleral-buckle
#16
Dilraj S Grewal, Tamer H Mahmoud
A 54-year-old male developed symptomatic scleral buckle exposure 16 years after placement and presented with large conjunctival defects with fibrosed edges. Following surgical removal of the buckle elements, primary conjunctival closure could not be achieved due to significant wound tension despite undermining the conjunctival edges to mobilize the conjunctiva. A dehydrated amniotic membrane graft (Ambio5; IOP Ophthalmics, Costa Mesa, CA) was placed on the scleral bed and secured in place with fibrin sealant (TISSEEL; Baxter International, Westlake Village, CA)...
October 1, 2016: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/27728942/biosurgicals-and-the-minimally-invasive-gynecologic-surgery-migs-surgeon
#17
James Dana Kondrup, Frances R Anderson, Melanie Rose Katz
Biosurgical materials (biosurgicals) have a wide array of uses for providing hemostasis, including decreasing the risk of postoperative bleeding and, intraoperatively, controling bleeding. These materials are especially useful in situations where electrocautery, sutures, or clips are not feasible. Biosurgicals have long been used in general surgery and surgical subspecialties to provide hemostasis; however, they still are not commonly used during obstetric and gynecologic procedures. Three commonly used classes of biosurgicals will be discussed in this article: oxidized regenerated cellulose, flowables, fibrin sealants, and fibrin sealant patches...
October 6, 2016: Surgical Technology International
https://www.readbyqxmd.com/read/27714778/meta-analysis-of-the-use-of-surgical-sealants-for-suture-hole-bleeding-in-arterial-anastomoses
#18
REVIEW
A C Rogers, L P Turley, K S Cross, M P McMonagle
BACKGROUND: Suture-hole bleeding in arterial anastomoses prolongs operating time and increases blood loss, particularly with the use of prosthetic grafts. Surgical sealants (such as fibrin) may be used as haemostatic adjuncts in vascular surgery. This is a systematic review and meta-analysis of published studies that investigated the utility of surgical sealants in arterial-to-prosthetic graft anastomoses. METHODS: A systematic review was undertaken of papers published until January 2015 on Embase, MEDLINE, PubMed, PubMed Central and Cochrane databases that analysed the use of surgical sealants as haemostatic adjuncts after arterial anastomoses...
December 2016: British Journal of Surgery
https://www.readbyqxmd.com/read/27703386/a-hospital-cost-analysis-of-a-fibrin-sealant-patch-in-soft-tissue-and-hepatic-surgical-bleeding
#19
Mitra Corral, Nicole Ferko, Andrew Hogan, Sarah S Hollmann, Gaurav Gangoli, Nadine Jamous, Jonathan Batiller, Richard Kocharian
BACKGROUND: Despite hemostat use, uncontrolled surgical bleeding is prevalent. Drawbacks of current hemostats include limitations with efficacy on first attempt and suboptimal ease-of-use. Evarrest(®) is a novel fibrin sealant patch that has demonstrated high hemostatic efficacy compared with standard of care across bleeding severities. The objective of this study was to conduct a hospital cost analysis of the fibrin sealant patch versus standard of care in soft tissue and hepatic surgical bleeding...
2016: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/27659639/the-undergraduate-preparation-of-dentists-confidence-levels-of-final-year-dental-students-at-the-school-of-dentistry-in-cardiff
#20
A S M Gilmour, A Welply, J G Cowpe, A D Bullock, R J Jones
Objective To investigate the self-reported confidence and preparedness of final year undergraduate students in undertaking a range of clinical procedures.Methods A questionnaire was distributed to final year dental students at Cardiff University, six months prior to graduation. Respondents rated their confidence in undertaking 39 clinical procedures using a 5-point scale (1 = can undertake on own with confidence, 5 = unable to undertake). Students also responded yes/no to experiencing four difficulties and to three statements about general preparedness...
September 23, 2016: British Dental Journal
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