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https://www.readbyqxmd.com/read/28182825/biosurgical-hemostatic-agents-in-neurosurgical-intracranial-procedures
#1
Roberto Gazzeri, Marcelo Galarza, Giorgio Callovini, Alex Alfieri
Intraoperative hemostasis during neurosurgical procedures is one of the most important aspects of intracranial surgery. Hemostasis is mandatory to keep a clean operative field and to prevent blood loss and postoperative hemorrhage. In neurosurgical practice, biosurgical hemostatic agents have proved to be extremely useful to complete the more classic use of electrocoagulation. During recent years, many biosurgical topical hemostatic agents were created. Although routinely used during neurosurgical procedures, there is still a great deal of confusion concerning optimal use of these products, because of the wide range of products, as absorbable topical agents, antifibrinolytics agents, fibrin sealants and hemostatic matrix, which perform their hemostatic action in different ways...
February 7, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28170219/on-demand-dissolution-of-chemically-cross-linked-hydrogels
#2
Marlena D Konieczynska, Mark W Grinstaff
The formation and subsequent on-demand dissolution of chemically cross-linked hydrogels is of keen interest to chemists, engineers, and clinicians. In this Account, we summarize our recent advances in the area of dissolvable chemically cross-linked hydrogels and provide a comparative discussion of other recent hydrogel systems. Using biocompatible macromonomers, we developed a library of cross-linked dendritic hydrogels that possess favorable properties, including biocompatibility, tissue adhesion, and swelling...
February 7, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28161131/use-of-low-thrombin-fibrin-sealant-glue-after-axillary-lymphadenectomy-for-breast-cancer-to-reduce-hospital-length-and-seroma
#3
Angelica Conversano, Chafika Mazouni, Anne Thomin, Amélie Gaudin, Marie Fournier, Françoise Rimareix, Julia Bonastre
BACKGROUND: Axillary lymphadenectomy for primary breast cancer produces a non-negligible rate of postoperative lymphorrhea, prolonged hospital stays, and multiple seroma punctures. We evaluated the impact of low-thrombin fibrin sealant glue on surgical wounds in patients undergoing axillary lymph node dissection for breast cancer. METHODS: We conducted an observational study of 149 patients who underwent axillary lymphadenectomy for primary breast cancer between January 2014 and December 2015...
January 10, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28133584/preservation-of-the-myofascial-cuff-during-posterior-fossa-surgery-to-reduce-the-rate-of-pseudomeningocele-formation-and-cerebrospinal-fluid-leak-a-technical-note
#4
Daniel R Felbaum, Kyle Mueller, Amjad Anaizi, Robert B Mason, Walter C Jean, Jean M Voyadzis
INTRODUCTION:  Suboccipital craniotomy is a workhorse neurosurgical operation for approaching the posterior fossa but carries a high risk of pseudomeningocele and cerebrospinal fluid (CSF) leak. We describe our experience with a simple T-shaped fascial opening that preserves the occipital myofascial cuff as compared to traditional methods to reduce this risk. METHODS:  A single institution, retrospective review of prospectively collected database was performed of patients that underwent a suboccipital craniectomy or craniotomy...
December 28, 2016: Curēus
https://www.readbyqxmd.com/read/28131944/a-novel-injectable-tissue-adhesive-based-on-oxidized-dextran-and-chitosan
#5
Biji Balakrishnan, Dawlee Soman, Umashanker Payanam, Alexandre Laurent, Denis Labarre, Athipettah Jayakrishnan
: A surgical adhesive that can be used in different surgical situations with or without sutures is a surgeons' dream and yet none has been able to fulfill many such demanding requirements. It was therefore a major challenge to develop an adhesive biomaterial that stops bleeding and bond tissues well, which at the same time is non-toxic, biocompatible and yet biodegradable, economically viable and appealing to the surgeon in terms of the simplicity of application in complex surgical situations...
January 25, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28130927/fibrin-sealants-in-soft-tissue-surgery-of-the-head-and-neck-a-systematic-review-and-meta-analysis-of-randomised-controlled-trials
#6
M S Bajwa, C Tudur-Smith, R J Shaw, A G Schache
BACKGROUND: Fibrin sealants (FS) are commercially available products used in surgical wounds as adjuncts to haemostasis and closure of dead space. The role of FS in soft-tissue head and neck surgery has not been established. OBJECTIVES: To assess if FS improves wound related outcomes in patients undergoing soft-tissue surgery of the head and neck anatomical region that would commonly require a drain. TYPE OF REVIEW: Systematic review and meta-analysis of randomised controlled trials (RCTs)...
January 28, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28124132/tranexamic-acid-versus-fibrin-sealant-in-primary-total-hip-replacement-a-comparative-study
#7
Aatif Mahmood, Seif Sawalha, Aaron Borbora, Gunasekaran Kumar, Viju Peter
BACKGROUND: The effectiveness of intravenous tranexamic acid (TA) in reducing blood loss and transfusion requirements during total hip replacement (THR) is well recognised. The aim of this study was to assess the effectiveness of a fibrin sealant in comparison to intravenous TA and a control group. PATIENTS AND METHODS: We prospectively studied 273 patients with primary hip osteoarthritis who underwent a THR between February 2012 and September 2013. The first 73 patients acted as the control group...
January 25, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28110072/structuring-of-composite-hydrogel-bioadhesives-and-its-effect-on-properties-and-bonding-mechanism
#8
Oded Pinkas, Daniella Goder, Roni Noyvirt, Sivan Peleg, Maayan Kahlon, Meital Zilberman
: Bioadhesives are polymeric hydrogels that can adhere to a tissue after crosslinking and are an essential element in nearly all surgeries worldwide. Several bioadhesives are commercially available. However, none of them are ideal. The main limitation of current tissue adhesives is the tradeoff between biocompatibility and mechanical strength, especially in wet hemorrhagic environments. Our novel bioadhesives are based on the natural polymers gelatin (coldwater fish) and alginate, crosslinked by carbodiimide (EDC)...
January 18, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28051764/the-use-of-fibrin-sealant-during-non-emergency-surgery-a-systematic-review-of-evidence-of-benefits-and-harms
#9
Steven J Edwards, Fay Crawford, Michelle Helena van Velthoven, Andrea Berardi, George Osei-Assibey, Mariana Bacelar, Fatima Salih, Victoria Wakefield
BACKGROUND: Fibrin sealants are used in different types of surgery to prevent the accumulation of post-operative fluid (seroma) or blood (haematoma) or to arrest haemorrhage (bleeding). However, there is uncertainty around the benefits and harms of fibrin sealant use. OBJECTIVES: To systematically review the evidence on the benefits and harms of fibrin sealants in non-emergency surgery in adults. DATA SOURCES: Electronic databases [MEDLINE, EMBASE and The Cochrane Library (including the Cochrane Database of Systematic Reviews, the Database of Abstracts of Reviews of Effects, the Health Technology Assessment database and the Cochrane Central Register of Controlled Trials)] were searched from inception to May 2015...
December 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28043785/tissue-sealants-may-reduce-haematoma-and-complications-in-face-lifts-a-meta-analysis-of-comparative-studies
#10
REVIEW
Salvatore Giordano, Ilkka Koskivuo, Erkki Suominen, Esko Veräjänkorva
: The use of tissue sealants has increased among different surgical specialities. Face-lift and rhytidoplasty may cause several complications such as haematoma, ecchymosis, oedema, seroma, skin necrosis, wound dehiscence and wound infection. However, administration of tissue sealants may prevent the occurrence of some complications. We performed a meta-analysis of studies that compared tissue sealant use with controls to evaluate the outcomes. A systematic literature search was performed...
December 15, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28039851/in-vitro-comparison-of-two-widely-used-surgical-sealants-for-treating-alveolar-air-leak
#11
Ruoyu Zhang, Maximilian Bures, Klaus Höffler, Danny Jonigk, Axel Haverich, Marcus Krueger
No abstract text is available yet for this article.
December 31, 2016: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/28029534/the-influence-of-fellowship-training-on-the-practice-of-pancreatoduodenectomy
#12
Gregory T Kennedy, Matthew T McMillan, Michael H Sprys, Claudio Bassi, Paul D Greig, Paul D Hansen, Dhiresh R Jeyarajah, Tara S Kent, Giuseppe Malleo, Giovanni Marchegiani, Rebecca M Minter, Charles M Vollmer
BACKGROUND: There has been a proliferation of gastrointestinal surgical fellowships; however, little is known regarding their association with surgical volume and management approaches. METHODS: Surveys were distributed to members of GI surgical societies. Responses were evaluated to define relationships between fellowship training and surgical practice with pancreatoduodenectomy (PD). RESULTS: Surveys were completed by 889 surgeons, 84.1% of whom had completed fellowship training...
October 28, 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28008551/surgical-treatment-of-large-incisional-hernias-with-intraperitoneal-composite-mesh-a-cohort-study
#13
B Lasses Martínez, M J Peña Soria, J J Cabeza Gómez, D Jiménez Valladolid, M Flores Gamarra, C Fernández Pérez, A Torres García, I Delgado Lillo
PURPOSE: Patients with large incisional hernias have significant morbidity and their management is a challenge for the surgical team because of the large abdominal wall involvement. The choice of surgical technique is still controversial. The purpose of this study is to analyze the predictive factors for recurrence after intraperitoneal mesh repair in patients with large incisional hernias. METHODS: A retrospective cohort observational study with a prospectively collected database was performed in the Hospital Clinico San Carlos (Madrid, Spain)...
December 22, 2016: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/27988916/experimental-study-of-intraparenchymal-fibrinogen-and-topical-thrombin-to-seal-pleural-defects
#14
Jun Yamamoto, Mitsutomo Kohno, Naoko Izawa, Toshinari Ema, Tai Hato, Ikuo Kamiyama, Takashi Ohtsuka, Masazumi Watanabe
OBJECTIVE: Fibrin sealants are used to close surgical pleural defects, but may detach, causing a postoperative air-leak. We investigated a new means of applying fibrin glue for closing pleural defects. METHODS: Pleural defects (10-mm and 4-mm diameters, respectively) were created in swine and rats via thoracotomy. They were sealed by a) injection of a fibrinogen solution into the lung parenchyma after instillation of a thrombin solution onto the pleural defect (group A), b) fibrinogen and thrombin spray (group B), c) fibrinogen instillation and a thrombin-dipped polyglycolic acid sheet (group C), or d) fibrin glue-coated collagen fleece (group D)...
December 20, 2016: Tokai Journal of Experimental and Clinical Medicine
https://www.readbyqxmd.com/read/27972289/a-retrospective-premier-database-study-to-evaluate-differences-between-progel%C3%A2-pleural-air-leak-sealant-as-compared-with-other-sealants-in-the-inpatient-surgical-setting
#15
K Mortman, M Corral, X Zhang, I Berhane, M Bourque, N Ferko
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27972269/economic-analysis-of-evarrest-sealant-matrix-compared-with-standard-of-care-in-severe-soft-tissue-surgical-bleeding-a-france-hospital-perspective
#16
N Jamous, T N Thanh, N Ferko, A Hogan, J Batiller, R Kocharian, W Danker Iii
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27956071/solution-blow-spun-polymer-a-novel-preclinical-surgical-sealant-for-bowel-anastomoses
#17
Nora G Kern, Adam M Behrens, Priya Srinivasan, Christopher T Rossi, John L Daristotle, Peter Kofinas, Anthony D Sandler
BACKGROUND: Solution blow spinning is a technique for depositing polymer fibers with promising potential use as a surgical sealant. This study assessed the feasibility and efficacy of solution blow spun polymer (BSP) for sealing bowel perforations in a mouse model of partial cecal transection. We then evaluated its use for reinforcing a surgical anastomosis in a preclinical piglet model. METHODS: Three commercially available surgical sealants (fibrin glue, polyethylene glycol (PEG) hydrogel, and cyanoacrylate) were compared to BSP in the ability to seal partially transected cecum in mice...
December 5, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27920230/troubleshooting-for-bleeding-in-thoracoscopic-anatomic-pulmonary-resection
#18
COMPARATIVE STUDY
Hitoshi Igai, Mitsuhiro Kamiyoshihara, Takashi Ibe, Natsuko Kawatani, Fumi Osawa, Ryohei Yoshikawa
Introduction The objective of this study was to evaluate intraoperative vessel injury and assess troubleshooting during thoracoscopic anatomic pulmonary resection. Methods Between April 2012 and March 2016, 240 patients underwent thoracoscopic anatomic lung resection, 26 of whom were identified as having massive bleeding intraoperatively. We analyzed the injured vessel and the hemostatic procedure employed, then compared the perioperative outcomes in patients with ( n = 26) and without ( n = 214) vessel injury...
January 2017: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/27917665/the-potential-effect-of-biological-sealants-on-colorectal-anastomosis-healing-in-experimental-research-involving-severe-diabetes
#19
K Stergios, K Kontzoglou, V Pergialiotis, L M Korou, M Frountzas, O Lalude, N Nikiteas, D N Perrea
Colorectal anastomoses continuous to pose a significant challenge in current surgical practice. Anastomotic leakage remains one of the most frequent and dramatic complications of colorectal surgery, even in centres of high specialisation. Diabetes is a well-established independent factor which results in higher anastomotic leakage rates. Fibrin sealants have been applied in experimental and clinical studies for the prevention of anastomotic dehiscence. However, little is known regarding their impact on diabetic patients...
December 5, 2016: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/27860350/enhanced-sealing-by-hydrophobic-modification-of-alaska-pollock-derived-gelatin-based-surgical-sealants-for-the-treatment-of-pulmonary-air-leaks
#20
Ryo Mizuta, Tetsushi Taguchi
Pulmonary air leaks are medical complications of thoracic surgery for which fibrin sealant is the main treatment. In this study, innovative sealants based on hydrophobically modified Alaska pollock-derived gelatin (hm-ApGltn) and a poly(ethylene)glycol-based 4-armed cross-linker (4S-PEG) have been developed and their burst strengths have been evaluated using fresh rat lung. The developed sealants show higher lung burst strength compared with the nonmodified original ApGltn (Org-ApGltn)-based sealant and a commercial fibrin sealant...
November 15, 2016: Macromolecular Bioscience
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