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Surgical sealant

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https://www.readbyqxmd.com/read/28927211/a-pivotal-randomized-clinical-trial-evaluating-the-safety-and-effectiveness-of-a-novel-hydrogel-dural-sealant-as-an-adjunct-to-dural-repair
#1
Michael J Strong, G Alexander West, Henry Woo, Daniel E Couture, John A Wilson, Lorenzo F Munoz, Charles L Rosen, Jeremy D Greenlee, Harry R van Loveren, Mark Iantosca, Clinton J Baird, Mark Smith, Matt McGirt, Jonathan Parish, Anthony L Asher
BACKGROUND: A watertight dural repair is critical to minimizing the risk of postoperative complications secondary to cerebrospinal fluid (CSF) leaks. OBJECTIVE: To evaluate the safety and efficacy of a novel hydrogel, Adherus Dural Sealant, when compared with control, DuraSeal Dural Sealant System, as an adjunct to standard methods of dural repair. METHODS: In this 17-center, prospective, randomized clinical trial designed as a noninferiority, single-blinded study, 124 patients received Adherus Dural Sealant (test sealant) and 126 received DuraSeal (control)...
April 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28920559/functional-mechanics-of-a-pectin-based-pleural-sealant-after-lung-injury
#2
Andrew B Servais, Cristian D Valenzuela, Arne Kienzle, Alexandra B Ysasi, Willi L Wagner, Akira Tsuda, Maximilian Ackermann, Steven J Mentzer
Pleural injury and associated air leaks are a major influence on patient morbidity and health care costs after lung surgery. Pectin, a plant-derived heteropolysaccharide, has recently demonstrated potential as an adhesive binding to the glycocalyx of visceral mesothelium. Since bioadhesion is a process likely involving the interpenetration of the pectin-based polymer with the glycocalyx, we predicted that the pectin-based polymer may also be an effective sealant for pleural injury. To explore the potential role of an equal weight % mixture of high-methoxyl pectin and carboxymethylcellulose as a pleural sealant, we compared the yield strength of the pectin-based polymer to commonly available surgical products...
September 16, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28917398/hydrogel-ocular-sealant-for-clear-corneal-incisions-in-cataract-surgery
#3
Nambi Nallasamy, Karen E Grove, Gary L Legault, Melissa B Daluvoy, Terry Kim
PURPOSE: To assess the relationship between use of a hydrogel ocular sealant (Resure) to secure clear corneal incisions (CCIs) in cataract surgery and surgeon efficiency, patient symptomatology, and postoperative results. SETTING: Duke University Eye Center, Durham, North Carolina, USA. DESIGN: Retrospective case series. METHODS: A 1:1 matched cohort of hydrogel sealant exposure-discordant eyes of cataract surgery patients was retrospectively generated...
August 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28902719/wound-closure-and-tissue-adhesives-in-clear-corneal-incision-cataract-surgery
#4
Amy Y Tong, Preeya K Gupta, Terry Kim
PURPOSE OF REVIEW: Achieving secure wound closure in clear corneal incision cataract surgery remains highly desired for its role in reducing infection risk and leak-related complications, including hypotony, corneal edema, and lens dislocation. Although classic techniques of stromal hydration or wound suturing represent traditional approaches, the introduction of newer and more effective ocular surface adhesives has increased the options that are available. This review aims to provide an update on the peer-reviewed literature regarding wound closure and the currently available and investigational tissue adhesives used to seal clear corneal incisions in cataract surgery...
September 11, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28870821/self-made-cost-reducing-hemostatic-agent-for-use-in-spine-surgery
#5
Fernando Alonso, Tarush Rustagi, Joe Iwanaga, Christian Fisahn, Rod Oskouian, R Shane Tubbs, Andrew Dailey, Jens R Chapman
Operative bleeding complications can lead to patient morbidity and mortality as well as longer and increased hospitalization costs. The use of matrix hemostatic sealants are commonly used to shorten the time to hemostasis, operative times and the need for blood transfusion. Commercially available hemostatic powders are used in spine surgery due to their ability to conform to wounds and decrease bleeding in difficult to access surgical sites. Hospital costs for these agents are variable and are dependent on negotiated institutional contracted prices...
September 1, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28867760/in-vitro-study-of-serial-changes-to-carmustine-wafers-gliadel-with-mr-imaging-and-computed-tomography
#6
Satoshi Doishita, Taro Shimono, Tetsuya Yoneda, Eiji Yamada, Taro Tsukamoto, Daichi Takemori, Daisuke Kimura, Hiroyuki Tatekawa, Shinichi Sakamoto, Yukio Miki
PURPOSE: Implantation of carmustine wafers (Gliadel) in vivo is accompanied by characteristic serial changes on magnetic resonance imaging (MRI) and computed tomography (CT), such as transient hyperintensity of the wafers on T1-weighted images (T1WIs) and considerable gas accumulation in surgical resection cavities. The purpose of this study was to evaluate intrinsic imaging changes to carmustine wafers in vitro. METHODS: Three phantoms simulating a surgical resection cavity were constructed...
September 4, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/28813710/is-endoscopic-vasectomy-just-a-dream-an-ex-vivo-study-on-feasibility-and-reliability-of-endoluminal-occlusion-of-porcine-vas-deferens
#7
Daniel Schlager, Moritz Maas, Simon Hein, Fabian Adams, Martin Schoenthaler, Bjoern Spittau, Ulrich Wetterauer, Arkadiusz Miernik
INTRODUCTION AND AIM: Surgical vasectomy remains the gold standard for fertility control in men. Endoluminal occlusion of the seminal ducts, thus avoiding an external incision, may become an appealing alternative to this approach. As our group has shown, nontraumatic endoscopic inspection of the seminal ducts is feasible in the human cadaver. We investigated the feasibility and reliability of occlusion using several commercially available medical sealing agents in the porcine vas deferens (VD)...
August 17, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28763366/does-bloodcare-powder-prevent-postoperative-chylous-ascites-after-lymphadenectomy-for-gynecological-malignancies
#8
Kemal Güngördük, Özgü Celikkol Güngördük, I Aykut Ozdemir, Mehmet Gokcu, Muzaffer Sanci
OBJECTIVE: The aim of this study was to evaluate the effect of an intraoperative hemostatic cellulose agent (BLOODCARE powder [Life Line, Brno, Czech Republic]) on reducing the incidence of postoperative chylous ascites (PCA) after complete pelvic and para-aortic lymphadenectomy (PPALN) in patients with gynecological cancers treated with laparotomy. METHODS: This case control study reviewed 150 patients with gynecological cancer who underwent PPALN. In the study group (n = 75), BLOODCARE powder was applied below the left renal vein and bilateral obturator fossa...
August 1, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28755096/analysis-of-the-hemostatic-potential-of-modern-topical-sealants-on-arterial-and-venous-anastomoses-an-experimental-porcine-study
#9
Hamidreza Fonouni, Arash Kashfi, Ali Majlesara, Oliver Stahlheber, Lukas Konstantinidis, Thomas W Kraus, Arianeb Mehrabi, Hani Oweira
One of the widely accepted adjunctive agents in the variety of surgical modalities are sealants. Our study aim was to compare four commonly used modern sealants in a standardized experimental setting to assess their feasibility, and hemostatic efficacy in vascular anastomosis. Forty landrace pigs (weight: 24.7 ± 3.8 kg) were randomized into the control (n = 8) and four sealant groups; TachoSil® (n = 8), Tissucol Duo® (n = 8), Coseal® (n = 8), and FloSeal® (n = 8). After doing a portal vein end-to-end anastomosis as well as stitches of aortic incision, the sealants were applied on anastomotic site...
September 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28736354/novel-technique-of-percutaneous-fat-graft-for-repair-of-persistent-large-pseudomeningocele
#10
Gabrielle Santangelo, Tyler Schmidt, Mithra Gonzalez, Per-Lennart Westesson, Howard Silberstein
BACKGROUND: Pseudomeningocele is an uncommon but problematic complication in lumbar spine surgery. Initial conservative measures are frequently successful but persistence requires additional management. The current surgical approach can involve a range of techniques, including blood patches, hydrogel/fibrin sealants, drains, open surgical repair of the dura or a combination of the above if symptoms persist. This report demonstrates a novel technique for repair using a percutaneous approach to deliver an autologous fat graft into the pseudomeningocele...
July 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28730275/comparative-analysis-of-open-and-robotic-transversus-abdominis-release-for-ventral-hernia-repair
#11
James G Bittner, Sameer Alrefai, Michelle Vy, Micah Mabe, Paul A R Del Prado, Natasha L Clingempeel
BACKGROUND: Transversus abdominis release (TAR) is a safe, effective strategy to repair complex ventral incisional hernia (VIH); however, open TAR (o-TAR) often necessitates prolonged hospitalization. Robot-assisted TAR (r-TAR) may benefit short-term outcomes and shorten convalescence. This study compares 90-day outcomes of o-TAR and r-TAR for VIH repair. METHODS: A single-center, retrospective review of patients who underwent o-TAR or r-TAR for VIH from 2015 to 2016 was conducted...
July 20, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28698899/methodical-endoscopic-repair-of-congenital-indirect-inguinoscrotal-hernia-in-adult-male-patients-with-completely-patent-processus-vaginalis
#12
C R Berney
PURPOSE: Indirect inguinal hernia related to the presence of a patent processus vaginalis (PPV) in adult is estimated to be around 15%. Most surgeons would favor a standard anterior hernioplasty to minimize the potential risk of damaging the spermatic cord structures that are always intimately fused to the congenital peritoneal sac. This also means overlooking the potential benefit of alternative posterior techniques such as endoscopic totally extraperitoneal (TEP) repair that is known to offer faster recovery with reduced risk of developing chronic groin pain...
July 11, 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/28695192/diagnosis-and-management-of-intraoperative-colorectal-anastomotic-leaks-a-global-retrospective-patient-chart-review-study
#13
A Schiff, S Roy, M Pignot, S K Ghosh, E J Fegelman
BACKGROUND: This targeted chart review study reports the first ever detailed global account of clinical approaches adopted to detect and manage anastomotic leaks identified during surgery in routine clinical practice. METHOD: 156 surgeons from eight countries retrospectively extracted data from surgical records of 458 patients who underwent colorectal surgery with an identified intraoperative leak at the circular anastomosis. Demographic details, procedures, and outcomes were analyzed descriptively, by country...
2017: Surgery Research and Practice
https://www.readbyqxmd.com/read/28688644/a-mussel-inspired-double-crosslinked-tissue-adhesive-on-rat-mastectomy-model-seroma-prevention-and-in%C3%A2-vivo-biocompatibility
#14
Wenzhen Zhu, Jian Yang, Jabed Iqbal, Yvonne Peck, Changjiang Fan, Dong-An Wang
BACKGROUND: Seroma formation is a common postsurgical complication of breast cancer surgery. It delays wound healing and may lead to other more serious complications. Conventional methods of reducing seroma formation through suturing or placement of surgical drainage produce inconsistent clinical outcomes. Tissue adhesives are viable alternatives but most of them are unsuitable for internal use and for large-area applications because of weak tissue adhesion strength or biocompatibility issues...
July 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28686537/far-from-standardized-using-surgical-videos-to-identify-variation-in-technique-for-laparoscopic-sleeve-gastrectomy
#15
Oliver A Varban, Adam Niemann, Amanda Stricklen, Rachel Ross, Amir A Ghaferi, Jonathan F Finks, Justin B Dimick
BACKGROUND: Video assessment is an emerging tool for understanding variation in surgical technique. METHODS: Representative videos of laparoscopic sleeve gastrectomy (LSG) were voluntarily submitted by 20 surgeons who participated in a statewide quality improvement collaborative. The amount of time required to complete the salient steps of the operation was measured and variations in the tasks performed during each step were captured. RESULTS: Twenty-two videos of LSG were submitted and 11 videos included concurrent hiatal hernia repair...
August 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28646685/a-highly-adhesive-and-naturally-derived-sealant
#16
Alexander Assmann, Andrea Vegh, Mohammad Ghasemi-Rad, Sara Bagherifard, George Cheng, Ehsan Shirzaei Sani, Guillermo U Ruiz-Esparza, Iman Noshadi, Antonio D Lassaletta, Sidhu Gangadharan, Ali Tamayol, Ali Khademhosseini, Nasim Annabi
Conventional surgical techniques to seal and repair defects in highly stressed elastic tissues are insufficient. Therefore, this study aimed to engineer an inexpensive, highly adhesive, biocompatible, and biodegradable sealant based on a modified and naturally derived biopolymer, gelatin methacryloyl (GelMA). We tuned the degree of gelatin modification, prepolymer concentration, photoinitiator concentration, and crosslinking conditions to optimize the physical properties and adhesion of the photocrosslinked GelMA sealants...
September 2017: Biomaterials
https://www.readbyqxmd.com/read/28621617/intrathoracic-meningocele-associated-with-neurofibromatosis-type-1-and-a-novel-technique-for-surgical-repair-case-report
#17
Paramita Das, Tarini Goyal, Matthew A Hunt
Neurofibromatosis Type 1 (NF1) is a neurocutaneous disorder that can have associated spinal abnormalities related to both bone and dural dysplasia. Thoracic meningoceles are one spine anomaly associated with NF1, although they are a fairly uncommon pathology. Surgical techniques to treat these meningoceles, usually undertaken only when the patient is symptomatic, are targeted at decreasing the size of the protrusion and improving lung capacity. Surgical interventions discussed in the literature include shunting the pseudomeningocele, primary repair with laminectomy, thoracoscopic plication, and reinforcement of the closure with cement, muscle, or fascia...
September 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28575349/safety-and-efficacy-of-a-novel-self-adhering-dural-substitute-in-a-canine-supratentorial-durotomy-model
#18
Kevin M Lewis, Jenifer Sweet, Scott T Wilson, Serge Rousselle, Heinz Gulle, Bernhard Baumgartner
BACKGROUND: Cerebrospinal fluid (CSF) leaks increase postoperative risk for complication, likelihood of reoperation, and costs. OBJECTIVE: To investigate a novel, self-adhering polyethylene glycol-coated collagen pad (PCC) as a dural substitute relative to Duragen XS (DGX; Integra LifeSciences Corporation, Plainsboro, New Jersey) and as a dural sealant relative to Tachosil (Takeda Austria GmbH, Linz, Austria), a fibrinogen and thrombin-coated collagen pad (FTC)...
June 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28557664/efficacy-of-laser-photobiomodulation-on-morphological-and-functional-repair-of-the-facial-nerve
#19
Daniela Vieira Buchaim, Jesus Carlos Andreo, Rui Seabra Ferreira Junior, Benedito Barraviera, Antonio de Castro Rodrigues, Mariana de Cássia Macedo, Geraldo Marco Rosa Junior, Andre Luis Shinohara, Iris Jasmin Santos German, Karina Torres Pomini, Rogerio Leone Buchaim
OBJECTIVE: Evaluate the efficacy of low-level laser therapy (LLLT) on qualitative, quantitative, and functional aspects in the facial nerve regeneration process. MATERIALS AND METHODS: Forty-two male Wistar rats were used, randomly divided into a control group (CG; n = 10), in which the facial nerve without lesion was collected, and four experimental groups: (1) suture experimental group (SEG) and (2) fibrin experimental group (FEG), consisting of 16 animals in which the buccal branch of the facial nerve was sectioned on both sides of the face; an end-to-end epineural suture was performed on the right side, and a fibrin sealant was used on the left side for coaptation of the stumps; and (3) laser suture experimental group (LSEG) and (4) laser fibrin experimental group (LFEG), consisting of 16 animals that underwent the same surgical procedures as SEG and FEG with the addition of laser application at three different points along the surgical site (pulsed laser of 830 nm wavelength, optical output power of 30 mW, power density of 0...
August 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28495063/topical-amiodarone-during-cardiac-surgery-does-epicardial-application-of-amiodarone-prevent-postoperative-atrial-fibrillation
#20
David Greenstein, Jordan Beau, Gary Gottlieb, Daniel Teller, Alexander Kulik
OBJECTIVES: Atrial fibrillation (AF) is a common complication after cardiac surgery. Topical amiodarone on the epicardium may help prevent postoperative AF while avoiding the side effects of its systemic administration. The purpose of this study was to evaluate the all-comer strategy of epicardial amiodarone application for the prevention of postoperative AF. METHODS: A retrospective observational study was performed that evaluated the incidence of new-onset AF in a consecutive series of cardiac surgery patients who were treated with either no amiodarone (historical control, n = 100), epicardial application of amiodarone mixed in a topical hydrogel (n = 50), or epicardial application of an amiodarone-soaked sealant patch (n = 50)...
September 2017: Journal of Thoracic and Cardiovascular Surgery
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