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Surgical sealant

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https://www.readbyqxmd.com/read/28646685/a-highly-adhesive-and-naturally-derived-sealant
#1
Alexander Assmann, Andrea Vegh, Mohammad Ghasemi-Rad, Sara Bagherifard, George Cheng, Ehsan Shirzaei Sani, Guillermo U Ruiz-Esparza, Iman Noshadi, Antonio D Lassaletta, Sidhu Gangadharan, Ali Tamayol, Ali Khademhosseini, Nasim Annabi
Conventional surgical techniques to seal and repair defects in highly stressed elastic tissues are insufficient. Therefore, this study aimed to engineer an inexpensive, highly adhesive, biocompatible, and biodegradable sealant based on a modified and naturally derived biopolymer, gelatin methacryloyl (GelMA). We tuned the degree of gelatin modification, prepolymer concentration, photoinitiator concentration, and crosslinking conditions to optimize the physical properties and adhesion of the photocrosslinked GelMA sealants...
June 6, 2017: Biomaterials
https://www.readbyqxmd.com/read/28621617/intrathoracic-meningocele-associated-with-neurofibromatosis-type-1-and-a-novel-technique-for-surgical-repair-case-report
#2
Paramita Das, Tarini Goyal, Matthew A Hunt
Neurofibromatosis Type 1 (NF1) is a neurocutaneous disorder that can have associated spinal abnormalities related to both bone and dural dysplasia. Thoracic meningoceles are one spine anomaly associated with NF1, although they are a fairly uncommon pathology. Surgical techniques to treat these meningoceles, usually undertaken only when the patient is symptomatic, are targeted at decreasing the size of the protrusion and improving lung capacity. Surgical interventions discussed in the literature include shunting the pseudomeningocele, primary repair with laminectomy, thoracoscopic plication, and reinforcement of the closure with cement, muscle, or fascia...
June 16, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28575349/safety-and-efficacy-of-a-novel-self-adhering-dural-substitute-in-a-canine-supratentorial-durotomy-model
#3
Kevin M Lewis, Jenifer Sweet, Scott T Wilson, Serge Rousselle, Heinz Gulle, Bernhard Baumgartner
BACKGROUND: Cerebrospinal fluid (CSF) leaks increase postoperative risk for complication, likelihood of reoperation, and costs. OBJECTIVE: To investigate a novel, self-adhering polyethylene glycol-coated collagen pad (PCC) as a dural substitute relative to Duragen XS (DGX; Integra LifeSciences Corporation, Plainsboro, New Jersey) and as a dural sealant relative to Tachosil (Takeda Austria GmbH, Linz, Austria), a fibrinogen and thrombin-coated collagen pad (FTC)...
June 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28557664/efficacy-of-laser-photobiomodulation-on-morphological-and-functional-repair-of-the-facial-nerve
#4
Daniela Vieira Buchaim, Jesus Carlos Andreo, Rui Seabra Ferreira Junior, Benedito Barraviera, Antonio de Castro Rodrigues, Mariana de Cássia Macedo, Geraldo Marco Rosa Junior, Andre Luis Shinohara, Iris Jasmin Santos German, Karina Torres Pomini, Rogerio Leone Buchaim
OBJECTIVE: Evaluate the efficacy of low-level laser therapy (LLLT) on qualitative, quantitative, and functional aspects in the facial nerve regeneration process. MATERIALS AND METHODS: Forty-two male Wistar rats were used, randomly divided into a control group (CG; n = 10), in which the facial nerve without lesion was collected, and four experimental groups: (1) suture experimental group (SEG) and (2) fibrin experimental group (FEG), consisting of 16 animals in which the buccal branch of the facial nerve was sectioned on both sides of the face; an end-to-end epineural suture was performed on the right side, and a fibrin sealant was used on the left side for coaptation of the stumps; and (3) laser suture experimental group (LSEG) and (4) laser fibrin experimental group (LFEG), consisting of 16 animals that underwent the same surgical procedures as SEG and FEG with the addition of laser application at three different points along the surgical site (pulsed laser of 830 nm wavelength, optical output power of 30 mW, power density of 0...
May 26, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28495063/topical-amiodarone-during-cardiac-surgery-does-epicardial-application-of-amiodarone-prevent-postoperative-atrial-fibrillation
#5
David Greenstein, Jordan Beau, Gary Gottlieb, Daniel Teller, Alexander Kulik
OBJECTIVES: Atrial fibrillation (AF) is a common complication after cardiac surgery. Topical amiodarone on the epicardium may help prevent postoperative AF while avoiding the side effects of its systemic administration. The purpose of this study was to evaluate the all-comer strategy of epicardial amiodarone application for the prevention of postoperative AF. METHODS: A retrospective observational study was performed that evaluated the incidence of new-onset AF in a consecutive series of cardiac surgery patients who were treated with either no amiodarone (historical control, n = 100), epicardial application of amiodarone mixed in a topical hydrogel (n = 50), or epicardial application of an amiodarone-soaked sealant patch (n = 50)...
April 13, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28492352/the-physiological-incubation-biosimulator-pibs-an-improved-ex-vivo-experimental-setup-for-the-mechanical-stability-of-biological-sealants-in-surgical-procedures
#6
Philipp Höhn, Marie Buchholz, Britta Majchrzak, Waldemar Uhl, Chris Braumann, Ansgar M Chromik
BACKGROUND: Tissue-bound fibrin sealants are used in a wide array of surgical procedures. The microenvironmental interaction between sealant and application site is often poorly evaluated due to a lack of suitable experimental models. METHODS: A physiological incubation biosimulator (PIBS) was developed to test biological sealants in an ex vivo setup under physiological conditions comparable to the microenvironment at application site (temperature, humidity, pressure)...
June 2017: Surgical Innovation
https://www.readbyqxmd.com/read/28474582/delayed-extensive-lumbar-sub-dural-effusion-following-discectomy-clinical-imaging-and-case-report
#7
Arun-Kumar Kaliya-Perumal, Meng-Ling Lu, Fu-Cheng Kao, Chi-Chien Niu
Incidental durotomy during lumbar spine surgery is a commonly reported complication. Those presenting with cerebrospinal fluid (CSF) leak are usually recognized and repaired intraoperatively. In some circumstances, it may either be unrecognised or occur as a delayed complication. Such delayed occurrences cannot be predicted and its management remain a challenge to the surgeon, especially when it presents as a subdural effusion. We report a 55-year-old man who underwent mini open lumbar discectomy through left side for a prolapsed L4-L5 disc...
March 2017: BioMedicine
https://www.readbyqxmd.com/read/28460205/cyanoacrylate-sealant-compared-to-fibrin-glue-in-staple-line-reinforcement-during-laparoscopic-sleeve-gastrectomy-pilot-prospective-observational-study
#8
G Martines, R Digennaro, M De Fazio, P Capuano
Laparoscopic Sleeve Gastrectomy (LSG) is associated with serious complications, such as staple line leaks and bleeding. This paper presents a novel approach aimed at the successful consolidation of the suture by the use of the cyanoacrylate, here compared to the use of fibrin glue. Fifty consecutive patients, recruited from October 2015 to March 2016, were submitted to laparoscopic sleeve gastrectomy by standardized surgical technique. The staple line was reinforced with cyanoacrylate or fibrin glue. There were no post-operative complications and no operative time prolongation...
January 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/28459951/localization-of-peripheral-pulmonary-lesions-to-aid-surgical-resection-a-novel-approach-for-electromagnetic-navigation-bronchoscopic-dye-marking%C3%A2
#9
Kongjia Luo, Yongbin Lin, Xiaodan Lin, Xiangyang Yu, Jing Wen, Kexing Xi, Peng Lin, Lanjun Zhang
OBJECTIVES: Video-assisted thoracoscopic sublobar resection of ultra-small, non-visible and non-palpable pulmonary lesions is challenging. The purpose of this study was to explore an alternative and efficient method for the localization of pulmonary lesions using electromagnetic navigation bronchoscopy (ENB). METHODS: Between May 2015 and April 2016, 24 consecutive patients with 30 pulmonary peripheral lesions underwent video-assisted thoracoscopic surgery for sublobar resection in our hospital...
April 28, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28449464/the-role-of-bioglue-in-thoracic-surgery-a-systematic-review
#10
Diamantis I Tsilimigras, Aspasia Antonopoulou, Ioannis Ntanasis-Stathopoulos, Davide Patrini, Kostas Papagiannopoulos, David Lawrence, Nikolaos Panagiotopoulos
BACKGROUND: BioGlue is a commonly used sealant in thoracic surgery. Prolonged air leak and presence of bronchopleural fistulae (BPF) are often encountered in clinical practice. We therefore, investigated the role and the efficacy of BioGlue in these scenarios. METHODS: A systematic review was conducted by searching Medline [1966-2016] and Cochrane Central Register of Controlled Trials (CENTRAL) [1999-2016] along with reference lists of the included studies. Included studies reported on thoracic surgery operations and use of BioGlue in thoracic surgical procedures, whereas excluded studies met at least one of the following criteria: non-English language studies, non-human population, studies on surgical specialties other than Thoracic surgery, reviews and meta-analyses and sealants other than BioGlue...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28419404/use-of-evicel-fibrin-sealant-in-optic-disc-pit-associated-macular-detachment
#11
Paulo Ricardo Chaves de Oliveira, Alan Richard Berger, David Robert Chow
Optic disc pit is a rare congenital anomaly of the optic nerve. Retinal detachment is a common complication with poor outcomes. Many surgical alternatives have been described for the treatment of this condition, producing variable results. Herein, the authors describe four cases of optic disc pit-associated macular detachment managed with pars plana vitrectomy, fluid-air exchange, drainage of subretinal fluid through the optic disc pit, temporal peripapillary laser, and application of Evicel fibrin sealant (human) (Ethicon, Bridgewater, NJ) over the optic disc head...
April 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28408847/cost-analysis-of-pulmonary-lobectomy-procedure-comparison-of-stapler-versus-precision-dissection-and-sealant
#12
Andrea Droghetti, Giuseppe Marulli, Jacopo Vannucci, Michele Giovanardi, Maria Caterina Bottoli, Mark Ragusa, Giovanni Muriana
OBJECTIVE: We aimed to evaluate the direct costs of pulmonary lobectomy hospitalization, comparing surgical techniques for the division of interlobar fissures: stapler (ST) versus electrocautery and hemostatic sealant patch (ES). METHODS: The cost comparison analysis was based on the clinical pathway and drawn up by collecting the information available from the Thoracic Surgery Division medical team at Mantova Hospital. Direct resource consumption was derived from a previous randomized controlled trial including 40 patients...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/28385501/percutaneous-embolization-of-delayed-external-carotid-artery-pseudoaneurysm-eight-years-after-partial-parathyroidectomy
#13
Antonella Laurito, Holta Kasemi, Andrea Monti, Mauro Maselli, Paola Manzo, Valeria Tavolini, Andrea Gaggiano
External carotid artery pseudoaneurysm (ECAP) is very rare. The usual mechanism is trauma or iatrogenic. We report a case of a patient with an asymptomatic, chronic ECAP secondary to partial parathyroidectomy. Percutaneous injection of the two-component Fibrin Sealant (Tisseel, Baxter int., Deerfield, IL) with the two active ingredients (Sealer Protein Solution and Thrombin Solution) was carried out with successful occlusion of the pseudoaneurysmal sac. The six-month follow up CT scan confirmed the ECAP thrombosis...
April 3, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28321657/novel-hemostatic-agents-based-on-gelatin-microbial-transglutaminase-mix
#14
Fang Lv, Xiaonan Cong, Wenshu Tang, Yiming Han, Yu Tang, Yongrui Liu, Liqiang Su, Mingyao Liu, Mingfei Jin, Zhengfang Yi
Hemostasis is a major challenge in surgical procedures and traumas. Conventional hemostatic methods have limited efficacy and may cause additional tissue damage. In this study, we designed a novel hemostatic agent based on the in situ gel formation of gelatin cross-linked by a novel microbial transglutaminase (mTGase), in which the amino acid sequences differed from commercial mTGases. The new hemostatic agent showed the same biochemical crosslinking chemistry as the final stages of the blood coagulation cascade while using gelatin as a "structural" protein (rather than fibrin) and a calcium-independent mTGase as the crosslinking catalyst (rather than factor XIIIa)...
March 17, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28293254/multiple-uses-of-fibrin-sealant-for-nervous-system-treatment-following-injury-and-disease
#15
REVIEW
Natalia Perussi Biscola, Luciana Politti Cartarozzi, Suzana Ulian-Benitez, Roberta Barbizan, Mateus Vidigal Castro, Aline Barroso Spejo, Rui Seabra Ferreira, Benedito Barraviera, Alexandre Leite Rodrigues Oliveira
Lesions to the nervous system often produce hemorrhage and tissue loss that are difficult, if not impossible, to repair. Therefore, scar formation, inflammation and cavitation take place, expanding the lesion epicenter. This significantly worsens the patient conditions and impairment, increasing neuronal loss and glial reaction, which in turn further decreases the chances of a positive outcome. The possibility of using hemostatic substances that also function as a scaffold, such as the fibrin sealant, reduces surgical time and improve postoperative recovery...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28267436/management-of-persistent-air-leaks
#16
REVIEW
Karen C Dugan, Balaji Laxmanan, Septimiu Murgu, D Kyle Hogarth
Alveolar-pleural fistulas causing persistent air leaks are associated with prolonged hospital stays and high morbidity. Prior guidelines recommend surgical repair as the gold standard for treatment, albeit a solution with limited success. In patients who have recently undergone thoracic surgery or in which surgery would be contraindicated based on severity of illness, there has been a lack of treatment options. This review describes a brief history of treatment guidelines for persistent air leaks. In the past 20 years, newer and less invasive treatment options have been developed...
March 3, 2017: Chest
https://www.readbyqxmd.com/read/28182825/biosurgical-hemostatic-agents-in-neurosurgical-intracranial-procedures
#17
Roberto Gazzeri, Marcelo Galarza, Giorgio Callovini, Alex Alfieri
Intraoperative hemostasis during neurosurgical procedures is one of the most important aspects of intracranial surgery. Hemostasis is mandatory to keep a clean operative field and to prevent blood loss and postoperative hemorrhage. In neurosurgical practice, biosurgical hemostatic agents have proved to be extremely useful to complete the more classic use of electrocoagulation. During recent years, many biosurgical topical hemostatic agents were created. Although routinely used during neurosurgical procedures, there is still a great deal of confusion concerning optimal use of these products, because of the wide range of products, as absorbable topical agents, antifibrinolytics agents, fibrin sealants and hemostatic matrix, which perform their hemostatic action in different ways...
February 7, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28170219/on-demand-dissolution-of-chemically-cross-linked-hydrogels
#18
Marlena D Konieczynska, Mark W Grinstaff
The formation and subsequent on-demand dissolution of chemically cross-linked hydrogels is of keen interest to chemists, engineers, and clinicians. In this Account, we summarize our recent advances in the area of dissolvable chemically cross-linked hydrogels and provide a comparative discussion of other recent hydrogel systems. Using biocompatible macromonomers, we developed a library of cross-linked dendritic hydrogels that possess favorable properties, including biocompatibility, tissue adhesion, and swelling...
February 21, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28161131/use-of-low-thrombin-fibrin-sealant-glue-after-axillary-lymphadenectomy-for-breast-cancer-to-reduce-hospital-length-and-seroma
#19
Angelica Conversano, Chafika Mazouni, Anne Thomin, Amélie Gaudin, Marie Fournier, Françoise Rimareix, Julia Bonastre
BACKGROUND: Axillary lymphadenectomy for primary breast cancer produces a non-negligible rate of postoperative lymphorrhea, prolonged hospital stays, and multiple seroma punctures. We evaluated the impact of low-thrombin fibrin sealant glue on surgical wounds in patients undergoing axillary lymph node dissection for breast cancer. METHODS: We conducted an observational study of 149 patients who underwent axillary lymphadenectomy for primary breast cancer between January 2014 and December 2015...
January 10, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28133584/preservation-of-the-myofascial-cuff-during-posterior-fossa-surgery-to-reduce-the-rate-of-pseudomeningocele-formation-and-cerebrospinal-fluid-leak-a-technical-note
#20
Daniel R Felbaum, Kyle Mueller, Amjad Anaizi, Robert B Mason, Walter C Jean, Jean M Voyadzis
INTRODUCTION:  Suboccipital craniotomy is a workhorse neurosurgical operation for approaching the posterior fossa but carries a high risk of pseudomeningocele and cerebrospinal fluid (CSF) leak. We describe our experience with a simple T-shaped fascial opening that preserves the occipital myofascial cuff as compared to traditional methods to reduce this risk. METHODS:  A single institution, retrospective review of prospectively collected database was performed of patients that underwent a suboccipital craniectomy or craniotomy...
December 28, 2016: Curēus
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