keyword
https://read.qxmd.com/read/38459598/detection-of-her2-expression-using-99m-tc-nm-02-nanobody-in-patients-with-breast-cancer-a-non-randomized-non-blinded-clinical-trial
#1
JOURNAL ARTICLE
Lingzhou Zhao, Yan Xing, Changcun Liu, Shaofei Ma, Wenhua Huang, Zhen Cheng, Jinhua Zhao
BACKGROUND: 99m Tc radiolabeled nanobody NM-02 (99m Tc-NM-02) is a novel single photon emission computed tomography (SPECT) probe with a high affinity and specificity for human epidermal growth factor receptor 2 (HER2). In this study, a clinical imaging trial was conducted to investigate the relationship between 99m Tc-NM-02 uptake and HER2 expression in patients with breast cancer. METHODS: Thirty patients with pathologically confirmed breast cancer were recruited and imaged with both 99m Tc-NM-02 SPECT/computed tomography (CT) and 18 F-fluorodeoxyglucose (18 F-FDG) positron emission tomography (PET)/CT...
March 8, 2024: Breast Cancer Research: BCR
https://read.qxmd.com/read/38396415/additional-value-of-fdg-pet-mri-complementary-to-sentinel-lymphonodectomy-for-minimal-invasive-lymph-node-staging-in-patients-with-endometrial-cancer-a-prospective-study
#2
JOURNAL ARTICLE
Matthias Weissinger, Lidia Bala, Sara Yvonne Brucker, Stefan Kommoss, Sascha Hoffmann, Ferdinand Seith, Konstantin Nikolaou, Christian la Fougère, Christina Barbara Walter, Helmut Dittmann
BACKGROUND: Lymph node metastases (LNM) are rare in early-stage endometrial cancer, but a diagnostic systematic lymphadenectomy (LNE) is often performed to achieve reliable N-staging. Therefore, this prospective study aimed to evaluate the benefit of [18F]-Fluorodeoxyglucose (FDG) PET/MRI complementary to SPECT/CT guided sentinel lymphonodectomy (SLNE) for a less invasive N-staging Methods: 79 patients underwent a whole-body FDG-PET/MRI, SLN mapping with 99m Tc-Nanocolloid SPECT/CT and indocyanine green (ICG) fluoroscopy followed by LNE which served as ground truth...
February 9, 2024: Diagnostics
https://read.qxmd.com/read/38342655/nuclear-medicine-and-molecular-imaging-applications-in-gynecologic-malignancies-a-comprehensive-review
#3
REVIEW
Tasnim Khessib, Priyanka Jha, Guido A Davidzon, Andrei Iagaru, Jagruti Shah
Gynecologic malignancies, consisting of endometrial, cervical, ovarian, vulvar, and vaginal cancers, pose significant diagnostic and management challenges due to their complex anatomic location and potential for rapid progression. These tumors cause substantial morbidity and mortality, often because of their delayed diagnosis and treatment. An estimated 19% of newly diagnosed cancers among women are gynecologic in origin. In recent years, there has been growing evidence supporting the integration of nuclear medicine imaging modalities in the diagnostic work-up and management of gynecologic cancers...
February 10, 2024: Seminars in Nuclear Medicine
https://read.qxmd.com/read/38255324/automatic-quantitative-assessment-for-diagnostic-and-therapeutic-response-in-rodent-myocardial-infarct-model
#4
JOURNAL ARTICLE
Kangsan Kim, Yong Jin Lee, Min Hwan Kim, Byung Hyun Byun, Sang-Keun Woo
The purpose of this study was to investigate the most appropriate methodological approach for the automatic measurement of rodent myocardial infarct polar map using histogram-based thresholding and unsupervised deep learning (DL)-based segmentation. A rat myocardial infarction model was induced by ligation of the left coronary artery. Positron emission tomography (PET) was performed 60 min after the administration of 18 F-fluoro-deoxy-glucose (18 F-FDG), and PET was performed after injecting 64 Cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone)...
January 18, 2024: Biomedicines
https://read.qxmd.com/read/38193393/synthesis-and-preliminary-study-of-99m-tc-labeled-hynic-fapi-for-imaging-of-fibroblast-activation-proteins-in-tumors
#5
JOURNAL ARTICLE
Mengshi Ma, Guangjie Yang, Min Zhao, Yao Liu, Xiaoguang Ge, Bing Jia, Shi Gao
Fibroblast activation protein (FAP) is an emerging target for cancer diagnosis. Different types of FAP inhibitor (FAPI)-based radiotracers have been developed and applied for tumor imaging. However, few FAPI tracers for single photon emission computed tomography (SPECT) imaging have been reported. SPECT imaging is less expensive and more widely distributed than positron emission tomography (PET), and thus, 99m Tc-labeled FAPIs would be more available to patients in developing regions. Herein, we developed a FAPI-04-derived radiotracer, HYNIC-FAPi-04 (HFAPi), for SPECT imaging...
January 9, 2024: Molecular Pharmaceutics
https://read.qxmd.com/read/38172001/spect-ct-pet-ct-and-pet-mri-for-response-assessment-of-bone-metastases
#6
REVIEW
Nazanin Zamani-Siahkali, Seyed Ali Mirshahvalad, Abolfazl Farbod, Ghasemali Divband, Christian Pirich, Patrick Veit-Haibach, Gary Cook, Mohsen Beheshti
Recent developments in hybrid SPECT/CT systems and the use of cadmium-zinc-telluride (CZT) detectors have improved the diagnostic accuracy of bone scintigraphy. These advancements have paved the way for novel quantitative approaches to accurate and reproducible treatment monitoring of bone metastases. PET/CT imaging using [18 F]F-FDG and [18 F]F-NaF have shown promising clinical utility in bone metastases assessment and monitoring response to therapy and prediction of treatment response in a broad range of malignancies...
January 2, 2024: Seminars in Nuclear Medicine
https://read.qxmd.com/read/38016897/pet-ct-and-spect-ct-for-infection-in-joints-and-bones-an-overview-and-future-directions
#7
REVIEW
Kgomotso M G Mokoala, Honest Ndlovu, Ismaheel Lawal, Mike Machaba Sathekge
Infections of the bones and joints, if misdiagnosed, may result in serious morbidity and even mortality. A prompt diagnosis followed by appropriate management may reduce the socioeconomic impact of bone and joint infections. Morphologic imaging such as ultrasound and plain radiographs form the first line investigations, however, in early infections findings may be negative or nonspecific. Nuclear medicine imaging techniques play a complementary role to morphologic imaging in the diagnosis of bone and joint infections...
November 27, 2023: Seminars in Nuclear Medicine
https://read.qxmd.com/read/37974617/the-preparation-and-execution-of-exploratory-human-studies-on-novel-99m-tc-labeled-glucosamine-derivatives-containing-different-phenyl-isonitriles-as-promising-tumor-imaging-agents
#8
JOURNAL ARTICLE
Qianna Wang, Qianqian Gan, Yuhao Jiang, Di Xiao, Xiaoliang Chen, Junbo Zhang
As the "molecule of the century", 2-deoxy-2-[18 F]fluoro-d-glucose ([18 F]FDG) is a radioactive 18 F-labeled glucose derivative with a wide range of applications for positron emission tomography (PET) imaging. Single photon emission computed tomography (SPECT) imaging is widely used, but there is no clinical probe comparable to [18 F]FDG. In our previous work, [99m Tc]Tc-CN5DG and [99m Tc]Tc-CN7DG were successfully developed and achieved high-quality SPECT images. However, they still have the disadvantage of low tumor uptake and/or high uptake by nontarget organs...
November 10, 2023: ACS Pharmacology & Translational Science
https://read.qxmd.com/read/37914617/functional-imaging-in-musculoskeletal-disorders-in-menopause
#9
REVIEW
Luca Filippi, Riccardo Camedda, Viviana Frantellizzi, Nicoletta Urbano, Giuseppe De Vincentis, Orazio Schillaci
Menopause-related musculoskeletal (MSK) disorders include osteoporosis, osteoarthritis (OA), sarcopenia and sarco-obesity. This review focuses on the applications of nuclear medicine for the functional imaging of the aforementioned clinical conditions. Bone Scan (BS) with 99m Tc-labeled phosphonates, alone or in combination with MRI, can identify "fresh" vertebral collapse due to age-associated osteoporosis and provides quantitative parameters characterized by a good correlation with radiological indices in patients with OA...
October 31, 2023: Seminars in Nuclear Medicine
https://read.qxmd.com/read/37899523/-99m-tc-3prgd-2-spect-ct-imaging-for-diagnosing-lymph-node-metastasis-of-primary-malignant-lung-tumors
#10
JOURNAL ARTICLE
Liming Xiao, Shupeng Yu, Weina Xu, Yishan Sun, Jun Xin
OBJECTIVE: To evaluate 99m technetium-three polyethylene glycol spacers-arginine-glycine-aspartic acid (99m Tc-3PRGD2 ) single-photon emission computed tomography (SPECT)/computed tomography (CT) imaging for diagnosing lymph node metastasis of primary malignant lung neoplasms. MATERIALS AND METHODS: We prospectively enrolled 26 patients with primary malignant lung tumors who underwent 99m Tc-3PRGD2 SPECT/CT and 18 F-fluorodeoxyglucose (18 F-FDG) positron emission tomography (PET)/CT imaging...
November 2023: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://read.qxmd.com/read/37891375/current-status-and-perspectives-of-nuclear-cardiology
#11
REVIEW
Nagara Tamaki, Osamu Manabe
Nuclear cardiology has long been used to identify myocardial ischemia for appropriate treatment strategies for stable coronary artery disease (CAD). After the Ischemia Trial, it is time to reevaluate the significance of ischemia assessment. Functional imaging continues to play pivotal role in detecting microcirculatory disturbances. PET provides a clear image of blood flow distribution and is useful for the quantitative evaluation of myocardial flow reserve (MFR), which plays an important role in predicting treatment strategies and improving prognosis in CAD...
January 2024: Annals of Nuclear Medicine
https://read.qxmd.com/read/37573346/-99m-tc-macroaggregated-albumin-spect-ct-predictive-dosimetry-and-dose-response-relationship-in-uveal-melanoma-liver-metastases-treated-with-first-line-selective-internal-radiation-therapy
#12
JOURNAL ARTICLE
Flavian Tabotta, Silvano Gnesin, Vincent Dunet, Alexandre Ponti, Antonia Digklia, Sarah Boughdad, Niklaus Schaefer, John O Prior, Nicolas Villard, Georgia Tsoumakidou, Alban Denys, Rafael Duran
First-line selective internal radiation therapy (SIRT) showed promising outcomes in patients with uveal melanoma liver metastases (UMLM). Patient survival depends on liver's disease control. SIRT planning is essential and little is known about dosimetry. We investigated whether 99m Tc-MAA-SPECT/CT dosimetry could predict absorbed doses (AD) evaluated on 90 Y-PET/CT and assess the dose-response relationship in UMLM patients treated with first-line SIRT. This IRB-approved, single-center, retrospective analysis (prospectively collected cohort) included 12 patients (median age 63y, range 43-82)...
August 12, 2023: Scientific Reports
https://read.qxmd.com/read/37527043/thyroid-segmentation-using-perithyroidal-halo-layer-on-99m-tc-pertechnetate-thyroid-spect-ct-an-easy-and-reliable-method-for-accurate-quantification-of-thyroid-activity
#13
JOURNAL ARTICLE
Youngduk Seo, Won Won Lee, Gimun Kang, Min Ho Shong, Kyong Hye Joung, Seong Min Kim, Sungmin Jun
OBJECTIVE: In previous fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT) studies, tumor segmentation using peritumoral halo layer (PHL; SegPHL) was shown to be reliable and accurate segmentation method in various malignant tumors. We found that the halo layer also was observed on the 99m Tc-pertechnetate (99m TcO4 ) thyroid single photon emission computed tomography (SPECT)/CT. In the present study, we attempted to apply thyroid segmentation using the perithyroidal halo layer (PTHL; SegPTHL) on 99m TcO4 thyroid SPECT/CT and compared SegPTHL with CT-based thyroid segmentation (SegCT)...
August 4, 2023: Hellenic Journal of Nuclear Medicine
https://read.qxmd.com/read/37456177/fluorine-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-cardiac-viability-risk-stratification-in-comparison-with-euroscore-ii-for-revascularization-in-patients-with-left-ventricular-dysfunction
#14
JOURNAL ARTICLE
Brithika Yoganayaki Thangamuthu, Indirani Elangovan, Patel Asra, Shelley Simon, Immaneni Sathyamoorthy
BACKGROUND: Diagnostic value of fluorine 18-fluorodeoxyglucose positron emission tomography/computed tomography (F18-FDG PET/CT) in the assessment of myocardial viable segments is well known; hence, it can identify patients with left ventricular (LV) systolic dysfunction who may benefit from revascularization. The presence of significant myocardial viable segments before revascularization will offer better prognosis with reduced mortality and morbidity. However, the usage of F18-FDG PET/CT myocardial viability study in the presurgical risk stratification is limited...
2023: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://read.qxmd.com/read/37454338/potential-utility-of-68-ga-dota-fapi-04-as-a-broad-spectrum-benign-disease-imaging-agent-comparison-with-18-f-fdg-and-99m-tc-mdp
#15
JOURNAL ARTICLE
Yi Li, Li Deng, Yue Feng, Lin Liu, Furong Lv, Lin Qiu
OBJECTIVES: To compare the detection performance of [68 Ga]DOTA-FAPI-04 positron emission tomography/computed tomography (PET/CT) and [18 F]FDG PET/CT for patients with various benign diseases and that of [68 Ga]DOTA-FAPI-04 PET/CT and [99m Tc]MDP single-photon emission computed tomography/computed tomography (SPECT/CT) for patients with benign bone lesions. METHODS: This prospective study included 89 patients who underwent [18 F]FDG and [68 Ga]DOTA-FAPI-04 PET/CT and 22 patients who underwent [99m Tc]MDP SPECT/CT and [68 Ga]DOTA-FAPI-04 PET/CT...
July 16, 2023: European Radiology
https://read.qxmd.com/read/37367965/how-to-combine-cta-99m-tc-wbc-spect-ct-and-18-f-fdg-pet-ct-in-patients-with-suspected-abdominal-vascular-endograft-infections
#16
JOURNAL ARTICLE
Chiara Lauri, Giuseppe Campagna, Francesco Aloisi, Alessandro Posa, Roberto Iezzi, Pasqualino Sirignano, Maurizio Taurino, Alberto Signore
PURPOSE: We aimed at comparing 99m Tc-HMPAO white blood cells (99m Tc-WBC) scintigraphy, 18fluorine-fluorodeoxyglucose ([18 F]FDG) positron emission tomography/computed tomography (PET/CT) and CT angiography (CTA) in patients with suspected abdominal vascular graft or endograft infection (VGEI). Moreover, we attempted to define a new visual score for interpreting [18 F]FDG PET/CT scans aiming at increasing its specificity. METHODS: We prospectively compared 99m Tc-WBC SPECT/CT, [18 F]FDG PET/CT, and CTA in 26 patients with suspected abdominal VGEI...
June 27, 2023: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/37306763/lymphatic-mapping-for-image-guided-radiotherapy-in-patients-with-locally-advanced-uterine-cervical-cancer-a-feasibility-study
#17
JOURNAL ARTICLE
Judit A Adam, Edwin Poel, Berthe L F van Eck-Smit, Constantijne H Mom, Lukas J A Stalpers, Jaap Stoker, Shandra Bipat
BACKGROUND: Lymph node metastasis is an important prognostic factor in locally advanced cervical cancer (LACC). No imaging method can successfully detect all (micro)metastases. This may result in (lymph node) recurrence after chemoradiation. We hypothesized that lymphatic mapping could identify nodes at risk and if radiation treatment volumes are adapted based on the lymphatic map, (micro)metastases not shown on imaging could be treated. We investigated the feasibility of lymphatic mapping to image lymph nodes at risk for (micro)metastases in LACC and assessed the radiotherapy dose on the nodes at risk...
June 12, 2023: EJNMMI Research
https://read.qxmd.com/read/37187953/diagnosis-of-fungal-infection-candida-albicans-after-heart-transplantation-in-a-pediatric-case-with-fever-of-unknown-origin-role-of-99m-tc-ubi-spect-ct-and-18-f-fdg-pet-ct
#18
Hadi Malek, Raheleh Hedayati, Mahdi Maghsudi, Nahid Yaghoobi
The diagnosis of patients with fever of unknown origin (FUO) in pediatric heart transplantation is a challenging medical problem. The physician should differentiate between rejections, infections, malignancy, adrenal insufficiency, and drug fever. Immunosuppressive therapy in these patients exposes them to a high risk of developing a post-transplantation fungal infection. In this case, we discuss the diagnostic contribution of the 99m Tc-UBI scan and 18 F-FDG PET scan for diagnosis of fungal infection causing FUO in these patients...
June 2023: Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/37057325/-predictive-value-of-the-proportion-of-hibernating-myocardium-in-total-perfusion-defect-on-reverse-remodeling-in-patients-with-hfref-underwent-coronary-artery-bypass-graft
#19
JOURNAL ARTICLE
Y Lu, J Cao, E J Zhu, M X Gao, T T Mou, Y Zhang, X F Xie, Y Tian, M K Yun, J J Meng, X B Yang, Y Q Lai, R Dong, X L Zhang
Objective: To evaluate the predictive value of the proportion of hibernating myocardium (HM) in total perfusion defect (TPD) on reverse left ventricle remodeling (RR) after coronary artery bypass graft (CABG) in patients with heart failure with reduced ejection fraction (HFrEF) by 99m Tc-methoxyisobutylisonitrile (MIBI) single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) combined with 18 F-flurodeoxyglucose (FDG) gated myocardial imaging positron emission computed tomography (PET)...
April 24, 2023: Zhonghua Xin Xue Guan Bing za Zhi
https://read.qxmd.com/read/36986521/spect-imaging-with-tc-99m-labeled-hynic-fapi-04-to-extend-the-differential-time-window-in-evaluating-tumor-fibrosis
#20
JOURNAL ARTICLE
Xiu Luo, Zhe Zhang, Chao Cheng, Tao Wang, Danzhou Fang, Changjing Zuo, Gengbiao Yuan, Rou Li, Xiao Li
The so-far used Ga-68- or F-18-labelled tracers are of a relative short time window in differentiating tumor fibrosis. SPECT applicable imaging probe, 99m Tc-HYNIC-FAPI-04, was synthesized and evaluated in tumor cells and animal models of FAP-positive glioma and FAP-negative hepatoma, and then compared with 18 F-FDG or 68 Ga-FAPI-04 PET/CT. The radio-labeling rate of 99m Tc-HYNIC-FAPI-04 was greater than 90%, and the radiochemical purity was >99% after purification with sep-pak C18 column. In vitro cell uptake experiments of 99m Tc-HYNIC-FAPI-04 showed good FAP binding specificity, and the cellular uptake significantly decreased when blocked by DOTA-FAPI-04, reflecting the similar targeting mechanism of HYNIC-FAPI-04 and DOTA-FAPI-04...
March 10, 2023: Pharmaceuticals
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