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99m Tc SPECT

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https://www.readbyqxmd.com/read/29782596/diagnostic-performance-of-hybrid-cardiac-spect-ct-imaging-for-patients-with-takotsubo-cardiomyopathy
#1
Yasuro Sugihara, Yoshimitsu Fukushima, Shin-Ichiro Kumita, Hitoshi Takano, Wataru Shimizu
Background: The diagnostic performance of SPECT-only imaging for takotsubo cardiomyopathy (TC) is limited due to the lack of coronary artery distribution information. The aim of this study was to evaluate the diagnostic performance of hybrid cardiac SPECT/CT for patients with TC or acute coronary syndrome (ACS). Methods: Twenty-two patients with apical ballooning left ventricular (LV) dysfunction who underwent cardiac perfusion SPECT using 99m Tc-methoxy-isobutyl-isonitrile (MIBI), cardiac fatty-acid metabolism SPECT using 123 I-beta-methyl-P-iodophenyl-pentadecanoic acid (BMIPP), cardiac CT, and hybrid cardiac SPECT/CT imaging were analyzed...
2018: European journal of hybrid imaging
https://www.readbyqxmd.com/read/29780044/-effect-of-misregistration-between-spect-and-ct-images-on-attenuation-correction-for-quantitative-bone-spect-imaging
#2
Mika Sakoshi, Norikazu Matsutomo, Tomoaki Yamamoto, Eisuke Sato
PURPOSE: The aim of this study was to evaluate the effect of misregistration between single-photon emission computed tomography (SPECT) and computed tomography (CT) images on bone SPECT. METHODS: We acquired SPECT and CT images of a body phantom filled with bone-equivalent solution and 99m Tc for evaluation of bone SPECT. SPECT images were reconstructed using attenuation correction maps obtained by shifting the attenuation coefficients from non-shifted values (reference)...
2018: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/29778807/-18-f-fluoride-pet-ct-and-99m-tc-mdp-spect-ct-can-detect-bone-cancer-at-early-stage-in-rodents
#3
Christiano R R Alves, Daniele de P Faria, Camila de G Carneiro, Alexandre T Garcez, Vanessa P Gutierrez, Willian das Neves, Ney R de Almeida, Yara Cury, Roger Chammas, Patricia C Brum
Noninvasive imaging using positron emission tomography/computed tomography (PET/CT) and single photon emission computed tomography/computed tomography (SPECT/CT) are considered revolutionized approaches to detect bone cancer. Both PET/CT and SPECT/CT technologies have advanced to permit miniaturization, which has provided the advantage of including animals as their own controls in longitudinal studies. The present study was designed to evaluate the potential of PET/CT and SPECT/CT as research tools to detect bone cancer in rats...
May 17, 2018: Life Sciences
https://www.readbyqxmd.com/read/29777004/development-of-a-novel-spect-tracer-to-image-c-met-expression-in-non-small-cell-lung-cancer-in-a-human-tumor-xenograft
#4
Zhaoguo Han, Yadi Xiao, Kai Wang, Ji Yan, Zunyu Xiao, Fang Fang, Zhongnan Jin, Yang Liu, Xilin Sun, Baozhong Shen
Rationale: Elevated expression of the c-Met receptor plays a crucial role in cancers. In non-small cell lung cancer (NSCLC), aberrant activation of c-Met signaling pathway contributes to tumorigenesis and cancer progression, and may mediate acquired resistance to epidermal growth factor receptor-targeted therapy. c-Met is therefore emerging as a promising therapeutic target for treating NSCLC, and the methods for noninvasive in vivo assessment of c-Met expression will improve NSCLC treatment and diagnosis. Methods: A new peptide-based (cMBP) radiotracer targeting c-Met, 99m Tc-hydrazine nicotinamide (HYNIC)-cMBP, was developed for single photon emission computed tomography (SPECT) imaging...
May 18, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29764036/-comparison-of-prognostic-value-of-18-f-fdg-pet-ct-myocardial-metabolism-imaging-and-coronary-collateral-circulation-in-patients-with-cto-lesions
#5
G Y Zhai, J L Wang, Y Y Liu, Y J Zhou
Objective: To evaluate the location, extent of viable myocardial of chronic total coronary occlusions(CTO)lesions by (18)F-FDG PET myocardial metabolism imaging and then compare with coronary collateral circulation(CCC) to evaluate the prognostic evaluation in patients with CTO lesions. Methods: A total of Sixty consecutive patients with CTO lesions referred for viability assessment from April 2016 to April 2017 in Department of Cardiology, Beijing Anzhen Hospital were included in the study. These patients underwent (99m)Tc-sestamibi ECG-gated SPECT rest myocardial perfusion imaging and ECG-gated (18)F-FDG PET/CT myocardial metabolic imaging, as well as coronary arteriography were recruited in this study...
May 8, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29736562/evaluation-of-brain-nuclear-medicine-imaging-tracers-in-a-murine-model-of-sepsis-associated-encephalopathy
#6
Dávid Szöllősi, Nikolett Hegedűs, Dániel S Veres, Ildikó Futó, Ildikó Horváth, Noémi Kovács, Bernadett Martinecz, Ádám Dénes, Daniel Seifert, Ralf Bergmann, Ondřej Lebeda, Zoltán Varga, Zoltán Kaleta, Krisztián Szigeti, Domokos Máthé
PURPOSE: The purpose of this study was to evaluate a set of widely used nuclear medicine imaging agents as possible methods to study the early effects of systemic inflammation on the living brain in a mouse model of sepsis-associated encephalopathy (SAE). The lipopolysaccharide (LPS)-induced murine systemic inflammation model was selected as a model of SAE. PROCEDURES: C57BL/6 mice were used. A multimodal imaging protocol was carried out on each animal 4 h following the intravenous administration of LPS using the following tracers: [99m Tc][2,2-dimethyl-3-[(3E)-3-oxidoiminobutan-2-yl]azanidylpropyl]-[(3E)-3-hydroxyiminobutan-2-yl]azanide ([99m Tc]HMPAO) and ethyl-7-[125 I]iodo-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate ([125 I]iomazenil) to measure brain perfusion and neuronal damage, respectively; 2-deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG) to measure cerebral glucose uptake...
May 7, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29736155/noninferiority-of-99m-tc-ethylenedicysteine-glucosamine-as-an-alternative-analogue-to-18-f-fluorodeoxyglucose-in-the-detection-and-staging-of-non-small-cell-lung-cancer
#7
Dong Dai, F David Rollo, Jerry Bryant, E Edmund Kim
Objective. 99m Tc-ethylenedicysteine-glucosamine (99m Tc-EC-G) was developed as a potential alternative to 18 F-FDG for cancer imaging. A Phase 2 study was conducted to compare 18 F-FDG PET/CT and 99m Tc-EC-G SPECT/CT in the detection and staging of patients with non-small cell lung cancer (NSCLC). This study was aimed to demonstrate that 99m Tc-EC-G SPECT/CT was not inferior to 18 F-FDG PET/CT in patients with confirmed NSCLC. Methods. Seventeen patients with biopsy proven NSCLC were imaged with 99m Tc-EC-G and 18 F-FDG to detect and stage their cancers...
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29715145/liver-function-in-areas-of-hepatic-venous-congestion-after-hepatectomy-for-liver-cancer-99m-tc-gsa-spect-ct-fused-imaging-study
#8
Morikatsu Yoshida, Toru Beppu, Shinya Shiraishi, Noriko Tsuda, Fumi Sakamoto, Kunitaka Kuramoto, Hirohisa Okabe, Hidetoshi Nitta, Katsunori Imai, Seiji Tomiguchi, Hideo Baba, Yasuyuki Yamashita
Background/Aim: The sacrifice of a major hepatic vein can cause hepatic venous congestion (HVC). We evaluated the effects of HVC on regional liver function using the liver uptake value (LUV), that was calculated from 99m Tc-labeled-galactosyl-human-serum-albumin ( 99m Tc-GSA) single-photon emission computed tomography (SPECT) /contrast-enhanced computed tomography (CE-CT) fused images. Patients and Methods: Sixty-two patients underwent 99m Tc-GSA SPECT/CE-CT prior to hepatectomy for liver cancer and at 7 days after surgery were divided into groups with (n=8) and without HVC (n=54)...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29715105/preparation-and-in-vitro-and-in-vivo-characterization-of-the-tumor-specific-antigen-derived-peptide-as-a-potential-candidate-for-targeting-human-epidermal-growth-factor-receptor-2-positive-breast-carcinomas
#9
Subhani M Okarvi, Ibrahim Aljammaz
BACKGROUND/AIM: The human epidermal growth factor receptor (HER2) is considered as one of the most well-characterized tumor-associated antigens for cancer therapy and plays an important role in the growth and progression of breast cancer. Overexpression of HER2 in various cancers and the availability of its extracellular region makes it a clinically useful target for the development of tumor-antigen specific agents. In this study, we have prepared a HER2-targeted hybrid peptide as a single-photon emission computed tomography (SPECT) imaging probe and evaluated its tumor targeting potential in subcutaneous HER2-positive breast cancer xenograft models...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29713225/utility-of-quantitative-parameters-from-single-photon-emission-computed-tomography-computed-tomography-in-patients-with-destructive-thyroiditis
#10
Ji-Young Kim, Ji Hyun Kim, Jae Hoon Moon, Kyoung Min Kim, Tae Jung Oh, Dong-Hwa Lee, Young So, Won Woo Lee
Objective: Quantitative parameters from Tc-99m pertechnetate single-photon emission computed tomography/computed tomography (SPECT/CT) are emerging as novel diagnostic markers for functional thyroid diseases. We intended to assess the utility of SPECT/CT parameters in patients with destructive thyroiditis. Materials and Methods: Thirty-five destructive thyroiditis patients (7 males and 28 females; mean age, 47.3 ± 13.0 years) and 20 euthyroid patients (6 males and 14 females; mean age, 45...
May 2018: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/29704706/a-monte-carlo-study-on-the-performance-evaluation-of-a-parallel-hole-collimator-for-a-hirespect-a-dedicated-small-animal-spect
#11
Samira Abbaspour, Kaveh Tanha, Babak Mahmoudian, Majid Assadi, Jalil Pirayesh Islamian
Collimator geometry has an important contribution on the image quality in SPECT imaging. The purpose of this study was to investigate the effect of parallel hole collimator hole-size on the functional parameters (including the spatial resolution and sensitivity) and the image quality of a HiReSPECT imaging system using SIMIND Monte Carlo program. To find a proper trade-off between the sensitivity and spatial resolution, the collimator with hole diameter ranges of 0.3-1.5 mm (in steps of 0.3 mm) were used with a fixed septal and hole thickness values (0...
April 22, 2018: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29703018/multiple-unexpected-lesions-of-metachondromatosis-detected-by-technetium-99m-methylene-diphosphonate-spect-ct-a-case-report
#12
Zi Wang, Yuting Zou, Yu Chen, Yue Chen
RATIONALE: Metachondromatosis (MC) is a very rare genetic disease, which is infrequently reported worldwide, which leads to osteochondroma and enchondromatosis. The disease has been shown to be associated with loss of function of the tumor suppressor gene "protein tyrosine phosphatase, non-receptor type 11" (PTPN11). PATIENT CONCERNS: A 12-year-old female was admitted to the hospital with pain due to an enlarged mass in her left fifth finger. DIAGNOSIS: Examination of the left hand by computed tomography (CT) revealed an expanding type of round and low-density lesion in the fifth proximal phalanx...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29700129/regional-myocardial-perfusion-disturbance-in-experimental-chronic-chagas-cardiomyopathy
#13
Luciano F L Oliveira, James T Thackeray, José A Marin Neto, Minna M D Romano, Eduardo E V Carvalho, Jorge Mejia, Denise M Tanaka, Grace K Silva, Douglas R Abdalla, Carlos Malamut, Frank M Bengel, Maria L Higuchi, André Schmidt, Edécio Cunha-Neto, Marcus V Simões
Background: Altered myocardial perfusion is a common finding in chronic Chagas cardiomyopathy (CCC), but its underlying histologic changes have not been elucidated. We investigated the occurrence of myocardial perfusion defects (MPD) and the correlated regional changes to histology in an experimental model of CCC in hamsters. Methods: Female Syrian hamsters ( n = 34) were infected with 3.5x104 to 105 trypomastigote forms of T. cruzi Y-strain and 6 to 10 months afterwards were submitted to in vivo imaging including: rest 99m Tc-sestamibi SPECT imaging, segmental and global left ventricular (LV) function assessment by using 2D-echocardiogram, and 18 F-FDG PET for evaluation of myocardial viability...
April 26, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29696485/relationship-between-microvascular-changes-autonomic-denervation-and-myocardial-fibrosis-in-chagas-cardiomyopathy-evaluation-by-mri-and-spect-imaging
#14
Gustavo Canavaci Barizon, Marcus Vinicius Simões, André Schmidt, Leonardo Pippa Gadioli, Luiz Otávio Murta Junior
BACKGROUND: The relationship between microvasculopathy, autonomic denervation, and myocardial fibrosis, in Chagas cardiomyopathy is incompletely understood. The aim of this study was to explore the relative extent and anatomic distribution of myocardial hypoperfusion, autonomic denervation, and myocardial scarring using Single-Photon Emission Computerized Tomography (SPECT) imaging and Magnetic Resonance Imaging (MRI). METHODS: Thirteen patients with Chagas disease all had Iodine-123-metaiodobenzylguanidine (MIBG) SPECT, 99m Tc-Sestamibi (MIBI) rest-stress SPECT, and gadolinium late enhancement MRI imaging within a 2-month interval...
April 25, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29696442/the-best-of-both-worlds-a-hybrid-approach-for-optimal-pre-and-intraoperative-identification-of-sentinel-lymph-nodes
#15
G H KleinJan, E van Werkhoven, N S van den Berg, M B Karakullukcu, H J M A A Zijlmans, J A van der Hage, B A van de Wiel, T Buckle, W M C Klop, S Horenblas, R A Valdés Olmos, H G van der Poel, F W B van Leeuwen
PURPOSE: Hybrid image-guided surgery technologies such as combined radio- and fluorescence-guidance are increasingly gaining interest, but their added value still needs to be proven. In order to evaluate if and how fluorescence-guidance can help realize improvements beyond the current state-of-the-art in sentinel node (SN) biopsy procedures, use of the hybrid tracer indocyanine green (ICG)-99m Tc-nancolloid was evaluated in a large cohort of patients. PATIENTS AND METHODS: A prospective trial was conducted (n = 501 procedures) in a heterogeneous cohort of 495 patients with different malignancies (skin malignancies, oral cavity cancer, penile cancer, prostate cancer and vulva cancer)...
April 25, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29689381/on-the-use-of-superparamagnetic-hydroxyapatite-nanoparticles-as-an-agent-for-magnetic-and-nuclear-in-vivo-imaging
#16
Alessio Adamiano, Michele Iafisco, Monica Sandri, Martina Basini, Paolo Arosio, Tamara Canu, Giovanni Sitia, Antonio Esposito, Vincenzo Iannotti, Giovanni Ausanio, Eirini Fragogeorgi, Maritina Rouchota, George Loudos, Alessandro Lascialfari, Anna Tampieri
The identification of alternative biocompatible magnetic NPs for advanced clinical application is becoming an important need due to raising concerns about iron accumulation in soft issues associated to the administration of superparamagnetic iron oxide nanoparticles (NPs). Here, we report on the performance of previously synthetized iron-doped hydroxyapatite (FeHA) NPs as contrast agent for magnetic resonance imaging (MRI). The MRI contrast abilities of FeHA and Endorem® (dextran coated iron oxide NPs) were assessed by 1 H nuclear magnetic resonance relaxometry and their performance in healthy mice was monitored by a 7 Tesla scanner...
April 21, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29687324/imaging-vegf-receptors-and-%C3%AE-v-%C3%AE-3-integrins-in-a-mouse-hindlimb-ischemia-model-of-peripheral-arterial-disease
#17
Yared Tekabe, Qing Li, Geping Zhang, Jordan Johnson, Ann Marie Schmidt, Marina Backer, Joseph Backer, Lynne L Johnson
PURPOSE: To compare targeted imaging of vascular endothelial growth factor (VEGF) receptors vs. αv β3 integrins in a mouse hindlimb ischemia model of peripheral artery disease. PROCEDURES: Male wild-type (WT) C57BL/6 mice (8- to 10-week old) (n = 24) underwent left femoral artery ligation. The right leg served as control. Five days later, mice were injected with either VEGF receptor targeting [99m Tc]DOTA-PEG-scVEGF ([99m Tc]scV) (n = 8) or with αv β3 -targeting tracer [99m Tc]HYNIC-cycloRGD ([99m Tc]RGD) (n = 8) and underwent single photon emission computed tomography (SPECT) x-ray computed tomography imaging...
April 23, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29684537/genetic-imaging-study-with-tc-99m-trodat-1-spect-in-adolescents-with-adhd-using-oros-methylphenidate
#18
Aynur Pekcanlar Akay, Gamze Çapa Kaya, Samet Kose, Çiğdem Eresen Yazıcıoğlu, Handan Özek Erkuran, Sevay Alşen Güney, Kaya Oğuz, Duygu Keskin, Burak Baykara, Neslihan İnal Emiroğlu, Mine Şencan Eren, Sefa Kızıldağ, Türkan Ertay, Dua Özsoylu, Süha Miral, Hatice Durak, Ali Saffet Gönül, Luis Augusto Rohde
AIM: To examine theeffects on the brain of 2-month treatment withamethylphenidate extended-release formulation (OROS-MPH) using [Tc-99m ] TRODAT-1SPECT in a sample of treatment-naïve adolescents with Attention Deficit/Hyperactivity Disorder (ADHD). In addition, to assess whether risk alleles (homozygosity for 10-repeat allele at the DAT1 gene were associated with alterations in striatal DAT availability. METHODS: Twenty adolescents with ADHD underwent brain single-photon emission computed tomography (SPECT) scans with [Tc-99m ] TRODAT-1 at baseline and two months after starting OROS-MPH treatment with dosages up to 1 mg/kg/day...
April 20, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29680396/changes-in-canine-cerebral-perfusion-after-accelerated-high-frequency-repetitive-transcranial-magnetic-stimulation-hf-rtms-a-proof-of-concept-study
#19
R Dockx, C Baeken, R Duprat, F De Vos, J H Saunders, I Polis, K Audenaert, K Peremans
Repetitive transcranial magnetic stimulation (rTMS) has been proposed as a treatment for several neuropsychiatric disorders in human beings, but the neurobiological effects of rTMS in dogs have not been investigated to date. A proof of concept study was designed to evaluate the effect of rTMS on cerebral perfusion, measured with single photon emission computed tomography (SPECT), in dogs. An accelerated high frequency (aHF)-rTMS (20Hz) protocol was applied to the canine left frontal cortex. To accurately target this area, eight dogs underwent a 3 Tesla magnetic resonance imaging (MRI) scan before stimulation...
April 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29679191/myocardial-flow-reserve-derived-by-dynamic-perfusion-single-photon-emission-computed-tomography-reflects-the-severity-of-coronary-atherosclerosis
#20
Nobuo Iguchi, Yuko Utanohara, Yasuhiro Suzuki, Makoto Suzuki, Kenichi Hagiya, Ryosuke Higuchi, Itaru Takamisawa, Tetsuya Tobaru, Tetsuya Sumiyoshi, Mitsuaki Isobe
A novel single-photon emission computed tomography (SPECT) camera was developed to evaluate dynamic myocardial perfusion flow. However, it is unclear whether myocardial flow reserve (MFR) derived by dynamic perfusion SPECT using the novel SPECT camera (D-SPECT) reflects the severity of coronary atherosclerosis. In the present study, we therefore examined the relationship between MFR using D-SPECT and severity of coronary lesions. The study population comprised 40 patients who underwent both a myocardial dynamic perfusion SPECT study and invasive coronary angiography...
April 20, 2018: International Journal of Cardiovascular Imaging
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