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https://www.readbyqxmd.com/read/28056732/development-of-a-radiolabeled-amlodipine-analog-for-l-type-calcium-channel-imaging
#1
Tahereh Firouzyar, Amir Reza Jalilian, Mohammad Reza Aboudzadeh, Hossein Sadeghpour, Mehrban Pooladi, Mahdi Shafiee-Ardestani, Ali Khalaj
PURPOSE: The non-invasive imaging and quantification of L-type calcium channels in living tissues is of great interest in diagnosis of congestive heart failure, myocardial hypertrophy, irritable bowel syndrome etc. METHODS: Technetium-<sup>99m</sup> labeled amlodipine conjugate ([<sup>99m</sup>Tc]-DTPA-AMLO) was prepared starting freshly eluted (<1 h) <sup>99m</sup>Technetium pertechnetate (86.5 MBq) and conjugated DTPA-AMLO at pH 5 in 30 min at room temperature in high radiochemical purity (>99%, RTLC; specific activity: 55-60 GBq/mmol)...
January 4, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/28050751/clinical-utility-of-18-f-fdg-positron-emission-tomography-computed-tomography-scan-vs-99m-tc-hmpao-white-blood-cell-single-photon-emission-computed-tomography-in-extra-cardiac-work-up-of-infective-endocarditis
#2
Trine K Lauridsen, Kasper K Iversen, Nikolaj Ihlemann, Philip Hasbak, Annika Loft, Anne K Berthelsen, Anders Dahl, Danijela Dejanovic, Elisabeth Albrecht-Beste, Jann Mortensen, Andreas Kjær, Henning Bundgaard, Niels Eske Bruun
The extra-cardiac work-up in infective endocarditis (IE) comprises a search for primary and secondary infective foci. Whether (18)FDG-PET/CT or WBC-SPECT/CT is superior in detection of clinically relevant extra-cardiac manifestations in IE is unexplored. The objectives of this study were to identify the numbers of positive findings detected by each imaging modality, to evaluate the clinical relevance of these findings and to define the reproducibility for extra-cardiac foci in patients with definite IE. Each modality was evaluated for numbers and location of positive extra-cardiac foci in patients with definite IE...
January 3, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28050750/a-novel-modality-for-functional-imaging-in-acute-intervertebral-disk-herniation-via-tracking-leukocyte-infiltration
#3
Li Xiao, Mengmeng Ding, Yi Zhang, Mahendra Chordia, Dongfeng Pan, Adam Shimer, Francis Shen, David Glover, Li Jin, Xudong Li
PURPOSE: Inflammation plays a key role in the progression of intervertebral disk (IVD) herniation and associated low back pain. However, real-time spatial diagnosis of inflammation associated with acute disk herniation has not been investigated. We sought to detect local neutrophil and macrophage infiltration near disk herniation via the formyl peptide receptor 1 (FPR1)-mediated molecular imaging in a disk puncture mouse model to elucidate pathophysiological process of disk herniation...
January 3, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28048559/we-ab-202-05-validation-of-lung-stress-maps-for-ct-ventilation-imaging
#4
G Cazoulat, J Kipritidis, S Siva, M Hofman, S Jolly, M Matuszak, J Balter, P Keall, K Brock
PURPOSE: To date, lung CT-ventilation imaging has been based on quantification of local breathing-induced changes in Hounsfield Units (HU) or volume. This work investigates the use of a stress map resulting from a biomechanical deformable image registration (DIR) algorithm as a metric of the ventilation function. METHOD: Eight lung cancer patients presenting different kinds of ventilation defects were retrospectively analyzed. Additionally, to the 4DCT acquired for radiotherapy planning, five of them had PET and three had SPECT imaging following inhalation of Ga-68 and Tc-99m, respectively...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048450/su-g-iep4-02-application-of-changs-attenuation-correction-technique-for-spect-partial-angle-acquisition-of-jaszczak-phantom
#5
K Saha, J Barbarits, R Humenik, J Johnson, B Murray, S Hoyt
PURPOSE: Chang's mathematical formulation is a common method of attenuation correction applied on reconstructed Jaszczak phantom images. Though Chang's attenuation correction method has been used for 360° angle acquisition, its applicability for 180° angle acquisition remains a question with one vendor's camera software producing artifacts. The objective of this work is to ensure that Chang's attenuation correction technique can be applied for reconstructed Jaszczak phantom images acquired in both 360° and 180° mode...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28043006/synthesis-and-evaluation-of-a-99m-tc-tricarbonyl-labeled-somatostatin-receptor-targeting-antagonist-peptide-for-imaging-of-neuroendocrine-tumors
#6
Lauren Radford, Fabio Gallazzi, Lisa Watkinson, Terry Carmack, Ashley Berendzen, Michael R Lewis, Silvia S Jurisson, Dionysia Papagiannopoulou, Heather M Hennkens
INTRODUCTION: A somatostatin receptor (SSTR)-targeting antagonist peptide (sst2-ANT) was radiolabeled with (99m)Tc tricarbonyl via a tridentate [N,S,N]-type ligand (L) to develop a radiodiagnostic agent, (99m)TcL-sst2-ANT, for imaging of SSTR-expressing neuroendocrine tumors. METHODS: Receptor affinity was assessed in vitro with the nonradioactive analogue, ReL-sst2-ANT, via a challenge experiment in AR42J cells with (125)I-SS-14 as the competing radioligand. Preparation of (99m)TcL-sst2-ANT was achieved via reaction of [(99m)Tc(CO)3(H2O)3](+) with L-sst2-ANT...
December 9, 2016: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28028974/myocardial-ischaemia-coronary-atherosclerosis-and-pulmonary-pressure-elevation-in-antiphospholipid-syndrome-patients
#7
Agnieszka Padjas, Wojciech Płazak, Magdalena Celińska-Lowenhoff, Adam Mazurek, Carlo Perricone, Piotr Podolec, Jacek Musiał
BACKGROUND: Thrombotic events in antiphospholipid syndrome (APS) involve venous and arterial circulation with the possible involvement of coronary or pulmonary microcirculation. OBJECTIVES: To evaluate the influence of antiphospholipid antibodies (aPL) and on myocardial ischaemia assessed by single-photon emission computerized tomography (SPECT), coronary atherosclerosis assessed by multidetector computerized tomography (MDCT) and pulmonary pressure assessed by transthoracic echocardiography (TTE) in patients with primary antiphospholipid syndrome (PAPS)...
November 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28025263/quantitative-plaque-features-from-coronary-computed-tomography-angiography-to-identify-regional-ischemia-by-myocardial-perfusion-imaging
#8
Mariana Diaz-Zamudio, Tobias A Fuchs, Piotr Slomka, Yuka Otaki, Reza Arsanjani, Heidi Gransar, Guido Germano, Daniel S Berman, Philipp A Kaufmann, Damini Dey
AIMS: We aimed to investigate whether quantitative plaque features measured from coronary CT angiography (CCTA) predict ischemia by myocardial perfusion SPECT imaging (MPI). METHODS AND RESULTS: Hundred and eighty-four consecutive patients (63% males) with suspected-coronary artery disease, undergoing hybrid CCTA, and attenuation corrected solid state (99m)Tc stress/rest MPI and single vessel ischemia were considered. Quantitative analysis of CCTA derived non-calcified plaque (NCP), low-density NCP [< 30 Hounsfield Units (HU)] (LDNCP), calcified and total plaque burdens (%, normalized to vessel volume), maximum diameter stenosis and contrast density difference (CD, maximum difference in HU/lumen area within lesion)...
December 26, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28024338/ultrasmall-biocompatible-bi2se3-nanodots-for-multimodal-imaging-guided-synergistic-radiophotothermal-therapy-against-cancer
#9
Fangxin Mao, Ling Wen, Caixia Sun, Shaohua Zhang, Guanglin Wang, Jianfeng Zeng, Yong Wang, Jianmin Ma, Mingyuan Gao, Zhen Li
Sub-3 nm ultrasmall Bi2Se3 nanodots stabilized with bovine serum albumin were successfully synthesized through a reaction of hydroxyethylthioselenide with bismuth chloride in aqueous solution under ambient conditions. These nanodots exhibit a high photothermal conversion efficiency (η = 50.7%) due to their strong broad absorbance in the near-infrared (NIR) window and serve as a nanotheranostic agent for photoacoustic imaging and photothermal cancer therapy. In addition, they also display radioenhancement with a ratio of 6% due to their sensitivity to X-rays, which makes them a potential sensitizer for radiotherapy...
December 27, 2016: ACS Nano
https://www.readbyqxmd.com/read/28012120/improvement-in-automated-quantitation-of-myocardial-perfusion-abnormality-by-using-iterative-reconstruction-image-in-combination-with-resolution-recovery-attenuation-and-scatter-corrections-for-the-detection-of-coronary-artery-disease
#10
Taiki Chono, Masahisa Onoguchi, Takayuki Shibutani, Akiyoshi Hashimoto, Tomoaki Nakata, Naoya Yama, Kazufumi Tsuchihashi, Masamitsu Hatakenaka
OBJECTIVE: An iterative reconstruction method in combination with resolution recovery, attenuation and scatter corrections (IR-RASC) can improve image quality. It, however, is undetermined whether this technique can improve the detection of coronary artery disease (CAD) when automated quantitative analysis is used. This study evaluated diagnostic values of IR-RASC in combination with automated quantitative analysis in stress myocardial perfusion imaging (MPI) in the CAD detection. METHODS: This study enrolled consecutive 64 patients (mean age 66...
December 24, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28007432/-188-re-image-performance-assessment-using-small-animal-multi-pinhole-spect-pet-ct-system
#11
Pedro L Esquinas, Cristina Rodríguez-Rodríguez, José Carlos De La Vega, Mehrdad Bokharaei, Katayoun Saatchi, Maryam Shirmohammad, Urs O Häfeli, Vesna Sossi, Anna Celler
PURPOSE: The goal of this study was to investigate the performance of a pre-clinical SPECT/PET/CT system for (188)Re imaging. METHODS: Phantom experiments were performed aiming to assess the characteristics of two multi-pinhole collimators: ultra-high resolution collimator (UHRC) and high-energy ultra high resolution collimator (HE-URHC) for imaging (188)Re. The spatial resolution, image contrast and contrast-to-noise ratio (CNR) were investigated using micro-Jaszczak phantoms...
December 19, 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/28004845/polymyalgia-rheumatica-detected-by-spect-ct-using-99m-tc-labeled-monoclonal-antibody-fab-fragments
#12
Anne Frölich, Ilka Schwarze, Christoph Neumann
No abstract text is available yet for this article.
December 22, 2016: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/28004791/free-triiodothyronine-level-correlates-with-myocardial-injury-and-prognosis-in-idiopathic-dilated-cardiomyopathy-evidence-from-cardiac-mri-and-spect-pet-imaging
#13
Wenyao Wang, Haixia Guan, Wei Fang, Kuo Zhang, A Martin Gerdes, Giorgio Iervasi, Yi-Da Tang
Thyroid dysfunction is associated with poor prognosis in heart failure, but theories of mechanisms are mainly based on animal experiments, not on human level. We aimed to explore the relation between thyroid function and myocardial injuries in idiopathic dilated cardiomyopathy (IDCM) using cardiac magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT) and positron emission tomography (PET). Myocardial fibrosis was detected by late gadolinium enhancement (LGE) MRI, and myocardial perfusion/metabolism was evaluated by (99m)Tc-MIBI SPECT /(18)F-FDG PET imaging...
December 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28000164/respiratory-average-ct-for-attenuation-correction-in-myocardial-perfusion-spect-ct
#14
Duo Zhang, Bang-Hung Yang, Nien Yun Wu, Greta Seng Peng Mok
OBJECTIVE: Cine average CT (CACT) and interpolated average CT (IACT) have been proposed to improve attenuation correction (AC) for PET/CT in oncologic and cardiac studies. This study aims to evaluate their effectiveness on myocardial perfusion SPECT/CT using computer simulation and physical phantom experiments. METHODS: We first simulated normal male with (99m)Tc-sestamibi distribution using digital XCAT phantom with respiratory motion amplitudes of 2, 3, and 4 cm...
December 20, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27992934/novel-99mtc-radiolabeled-anionic-linear-globular-peg-based-dendrimer-chlorambucil-non-invasive-method-for-in-vivo-biodistribution
#15
S M Ghoreishi, A Khalaj, A B-Rajabi, A D Azar, M S Ardestani, A Assadi
Chlorambucil (CBL) is an alkylating agent, which widely use in the treatment of various types of tumors. The main purpose of this study is to evaluate the in-vivo biodistribution of CBL conjugated to the anionic dendrimer, which has a great ability to labeled with (99m)Tc through binding to carboxylate terminate groups. Whole body scans were used to analyze the percentage of the injected dose in different times. Radiochemical purity (RCP) and in-vivo biodistribution were also calculated with the SPECT/CT instrument...
December 19, 2016: Drug Research
https://www.readbyqxmd.com/read/27987028/left-ventricular-function-in-response-to-dipyridamole-stress-head-to-head-comparison-between-82-rubidium-pet-and-99m-tc-sestamibi-spect-ecg-gated-myocardial-perfusion-imaging
#16
Maria Clementina Giorgi, Jose Claudio Meneghetti, Jose Soares, Marisa Izaki, Andréa Falcão, Rodrigo Imada, William Chalela, Marco Antonio de Oliveira, Cesar Nomura, Hein J Verberne
PURPOSE: Myocardial perfusion imaging (MPI) with (99m)Tc-sestamibi (sestamibi) SPECT and rubidium-82 ((82)Rb) PET both allow for combined assessment of perfusion and left ventricular (LV) function. We sought to compare parameters of LV function obtained with both methods using a single dipyridamole stress dose. MATERIALS AND METHODS: A group of 221 consecutive patients (65.2 ± 10.4 years, 52.9% male) underwent consecutive sestamibi and (82)Rb MPI after a single dipyridamole stress dose...
December 16, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27984781/simvastatin-augments-revascularization-and-reperfusion-in-a-murine-model-of-hind-limb-ischemia-multimodal-imaging-assessment
#17
Julian Luke Goggi, Michael Ng, Nalini Shenoy, Ramasamy Boominathan, Peter Cheng, Sakthivel Sekar, Kishore Kumar Bhakoo
INTRODUCTION: Peripheral artery disease can lead to severe disability and limb loss. Therapeutic strategies focussing on macrovascular repair have shown benefit but have not significantly reduced amputation rates in progressive PAD. Proangiogenic small molecule therapies may substantially improve vascularisation in limb ischemia. The purpose of the current study was to assess the proangiogenic effects of simvastatin in a murine model of hind limb ischemia using longitudinal multimodal imaging...
November 17, 2016: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/27977535/the-ideal-dual-isotope-imaging-combination-in-evaluating-patients-with-suspected-infection-of-pelvic-pressure-ulcers
#18
Sherif Heiba, Lewen Stempler, Timothy Sullivan, Dov Kolker, Lale Kostakoglu
INTRODUCTION: The successful management of infected pelvic pressure ulcer patients (PPUP) depends on the distinction between infections limited to soft tissue (STI) and those with underlying osteomyelitis (OM), which can be difficult to determine clinically. Dual-isotope (DI) comprehensive imaging has excellent accuracy in localizing diabetic foot infection and differentiating OM from STI with SPECT/CT utilization. In this study, we assess the accuracy and confidence of the different DI SPECT/CT imaging steps in PPUP with confirmed diagnoses...
December 13, 2016: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27941121/a-novel-copolymer-based-functional-spect-mr-imaging-agent-for-asialoglycoprotein-receptor-targeting
#19
Pu Zhang, Zhide Guo, Deliang Zhang, Chang Liu, Guibing Chen, Rongqiang Zhuang, Manli Song, Hua Wu, Xianzhong Zhang
The aim of this study is to develop a copolymer-based single-photon emission computed tomography/magnetic resonance (SPECT/MR) dual-modality imaging agent that can be labeled with both technetium-99m ((99m)Tc) and gadolinium (Gd) and target asialoglycoprotein receptor (ASGPR) via galactose. Monomers of N-p-vinylbenzyl-6-(2-(4-dimethylamino)benzaldehydehydrazono) nicotinate (VNI) for labeling of (99m)Tc, 5,8-bis(carboxymethyl)-3-oxo-11-(2-oxo-2-((4-vinylbenzyl)amino)ethyl)-1-(4-vinylphenzyl)-2,5,8,11-tetraazatridecan-13-oic acid (V2DTPA) for labeling of Gd, and vinylbenzyl-O-β-d-galactopyranosyl-d-gluconamide (VLA) for targeting ASGPR were synthesized, respectively...
2016: Molecular Imaging
https://www.readbyqxmd.com/read/27940150/cholinesterase-inhibitors-are-compatible-with-psychosocial-intervention-for-alzheimer-disease-patients-suggested-by-neuroimaging-findings
#20
Kenichi Meguro
We previously reported that the frontal lobe was stimulated by psychosocial intervention for dementia patients, and that the parietal lobe was associated with logical judgment. We hypothesized that the combined therapeutic approach with symptomatic drug treatment can directly stimulate not only attention function but also judgment function indirectly to observing other participants' behaviors. Fifty-two patients with Alzheimer disease underwent the group reminiscence approach with reality orientation, as well as the donepezil treatment...
January 30, 2017: Psychiatry Research
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