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https://www.readbyqxmd.com/read/29783101/chondrogenic-differentiation-in-vitro-of-hipscs-activates-pathways-engaged-in-limb-development
#1
Ewelina Stelcer, Katarzyna Kulcenty, Marcin Rucinski, Karol Jopek, Magdalena Richter, Tomasz Trzeciak, Wiktoria Maria Suchorska
No abstract text is available yet for this article.
May 18, 2018: Stem Cell Research
https://www.readbyqxmd.com/read/29783068/reliability-of-the-star-excursion-balance-test-and-two-new-similar-protocols-to-measure-trunk-postural-control
#2
Diego López-Plaza, Casto Juan-Recio, David Barbado, Iñaki Ruiz-Pérez, Francisco J Vera-Garcia
BACKGROUND: Although the Star Excursion Balance test (SEBT) has shown a good intra-session reliability the inter-session reliability of this test has not been deeply studied. Furthermore, there is an evident high influence of the lower-limbs in the performance of the SEBT so even if it has been used to measure core stability it is possibly not the most suitable measurement. OBJECTIVE: The aims of this study were: i) to assess the absolute and relative between-session reliability of the SEBT and two novel variations of this test to assess trunk postural control while sitting, i...
May 18, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29783059/disruption-of-medial-septum-and-diagonal-bands-of-broca-cholinergic-projections-to-the-ventral-hippocampus-disrupt-auditory-fear-memory
#3
Jennifer M Staib, Rebecca Della Valle, Dayan K Knox
In classical fear conditioning, a neutral conditioned stimulus (CS) is paired with an aversive unconditioned stimulus (US), which leads to a fear memory. If the CS is repeatedly presented without the US after fear conditioning, the formation of an extinction memory occurs, which inhibits fear memory expression. A previous study has demonstrated that selective cholinergic lesions in the medial septum and vertical limb of the diagonal bands of Broca (MS/vDBB) prior to fear and extinction learning disrupt contextual fear memory discrimination and acquisition of extinction memory...
May 18, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29783031/a-unique-all-payer-rate-setting-system-controls-the-cost-but-not-the-racial-disparity-in-lower-extremity-revascularization-procedures
#4
Besma Nejim, Robert J Beaulieu, Husain Alshaikh, Mohammed Hamouda, Joseph Canner, Mahmoud B Malas
BACKGROUND: Patients with peripheral arterial disease (PAD) often have high comorbidity burden that may complicate post-interventional course and drive increased healthcare expenditures. Racial disparity had been observed in lower extremity revascularization (LER) patterns and outcomes. In 2014, Maryland adopted an all-payer rate setting system to limit the rising hospitalization costs. This resulted in an aggregate payment system in which hospital compensation takes place as an overall per capita expenditure for hospital services...
May 18, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29783030/venous-conduits-have-superior-patency-compared-to-prosthetic-grafts-for-femoro-femoral-bypass
#5
Khanh Nguyen, Gregory Moneta, Gregory Landry
OBJECTIVE: To compare outcomes of externally supported polytetrafluoroethylene (PTFE) grafts and femoral vein as conduits for femoro-femoral crossover grafts. METHODS: This is a retrospective review of consecutive femoro-femoral crossover grafts at our institution between January 2005 and March 2016. Patient demographics, indications, complication rates, patency rates and survival rates were compared between femoro-femoral grafts created with either PTFE or femoral vein conduits, autogenous or cryopreserved...
May 18, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29782592/the-role-of-hybrid-bone-spect-ct-imaging-in-the-work-up-of-the-limping-patient-a-symptom-based-and-joint-oriented-review
#6
REVIEW
H K Mohan, K Strobel, W van der Bruggen, G Gnanasegaran, W U Kampen, T Kuwert, T Van den Wyngaert, F Paycha
A vast spectrum of lower limb bone and joint disorders (hip, knee, ankle, foot) present with a common clinical presentation: limping. Too often this symptom generates an inefficient cascade of imaging studies. This review attempts to optimise the diagnostic effectiveness of bone scintigraphy using the hybrid SPECT/CT technique in relation to the diagnostic clues provided by other imaging modalities, discusses the appropriate clinical indications, optimal scintigraphic procedures and illustrates updated image pattern-oriented reporting...
2018: Eur J Hybrid Imaging
https://www.readbyqxmd.com/read/29782494/ubiquitin-dependent-proteolysis-of-cxcl7-leads-to-posterior-longitudinal-ligament-ossification
#7
Michiyo Tsuru, Atsushi Ono, Hideaki Umeyama, Masahiro Takeuchi, Kensei Nagata
Ossification of the posterior longitudinal ligament (OPLL), a spinal ligament, reduces the range of motion in limbs. No treatment is currently available for OPLL, which is why therapies are urgently needed. OPLL occurs in obesity, is more common in men, and has an onset after 40 years of age. The mechanisms underlying OPLL remain unclear. In this study, we performed a serum proteomic analysis in both OPLL patients and healthy subjects to identify factors potentially involved in the development of OPLL, and found reduced levels of a protein that might underlie the pathology of OPLL...
2018: PloS One
https://www.readbyqxmd.com/read/29782430/novel-technique-of-distal-roux-en-y-gastric-bypass-for-insufficient-weight-loss-after-primary-procedure-personal-experience-and-primary-results-at-12-months
#8
Theodoros Thomopoulos, Vincent Tomasi, Evangelos Koliakos, Maximilien Thoma, Benoit Navez
PURPOSE: In the literature, up to 20% of patients present a failure of weight loss after primary Roux-en-Y gastric bypass (RYGBP) or other restrictive procedures. Our aim is to describe the midterm results of our novel technique of distal Roux-en-Y gastric bypass (DRYGBP) as a revisional procedure. MATERIALS AND METHODS: We performed our DRYGBP in 30 patients. The length of the common channel was 100 cm, whereas the lengths of the alimentary and the biliopancreatic limbs were 2/3 and 1/3 of the remaining bowel, respectively...
May 18, 2018: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/29782427/clinical-profile-of-levamisole-adulterated-cocaine-induced-vasculitis-vasculopathy-a-30-case-series
#9
Carlos Horacio Muñoz-Vahos, Sebastián Herrera-Uribe, Álvaro Arbeláez-Cortés, Daniel Jaramillo-Arroyave, Luis Alonso González-Naranjo, Gloria Vásquez-Duque, Mauricio Restrepo-Escobar, Luis Alfonso Correa-Londoño, Luis Fernando Arias-Restrepo, Adriana Lucía Vanegas-García
OBJECTIVES: The aims of this study were to describe clinical and laboratory manifestations of patients with levamisole-adulterated cocaine-induced vasculitis/vasculopathy and to propose a skin classification according to the distribution and severity of lesions. METHODS: We report the characteristics of 30 patients admitted with levamisole-adulterated cocaine-induced vasculitis/vasculopathy in 4 high-complexity institutions in Colombia, from December 2010 to May 2017...
May 19, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29782415/measuring-transcutaneous-oxygenation-to-validate-the-duration-required-to-achieve-electrode-equilibration
#10
Nathaniel Chiang, Jitendra K Jain, Jamie Sleigh, Thodur Vasudevan
OBJECTIVE: The transcutaneous oxygenation measurement (TCOM) system is useful in assessing tissue viability. There are no clear recommendations regarding the duration required for the electrode to equilibrate and reliably evaluate tissue oxygenation values. The objective of this study was to validate the duration required to achieve electrode equilibration in a clinical setting. METHODS: Minute-by-minute recordings using TCOM (TCOM3; Radiometer Medical ApS, Brønshøj, Copenhagen) were obtained for 82 limbs in 50 participants...
June 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29782346/claudins-and-nephrolithiasis
#11
Allein Plain, R Todd Alexander
PURPOSE OF REVIEW: The greatest risk factor for kidney stone formation is increased urinary calcium excretion. Most filtered calcium is reabsorbed from the proximal tubule and the thick ascending limb (TAL) of Henle's loop via a paracellular pathway. Claudins are tight junction proteins that confer the permeability properties of an epithelium. We review the contribution of renal claudins to nephron calcium permeability and how perturbations in these pathways cause alterations in tubular calcium transport, hypercalciuria, nephrocalcinosis, or nephrolithiasis...
May 17, 2018: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/29782306/urticarial-lesions-in-a-pregnant-woman
#12
Sergio Santos-Alarcón, Cesar Benavente-Villegas, Isabel García-Briz, Magdalena Moneva-Léniz, Celia Sanchis-Sánchez, Almudena Mateu-Puchades
Dear Editor, Gestational pemphigoid (GP) is a rare autoimmune bullous dermatosis in pregnancy. GP usually occurs during the second or third month of pregnancy. It clinically manifests as the development of either early-onset urticarial lesions or late-onset subepidermal blisters that may linger for weeks or even months. Herein we report the case of a 45-year-old woman with the distinctive clinical onset of GP. A forty-five-year-old woman, gravida I, para 0, at 27 weeks gestation, was referred for evaluation to our Department with an extensive pruritic eruption that had developed over the previous 7 days...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29782303/clindamycin-induced-maculopapular-exanthema-with-preferential-involvement-of-striae-distensae-a-koebner-phenomenon
#13
Benigno Monteagudo, Miguel Cabanillas, Pilar Iriarte, Aquilina Ramírez-Santos, Elvira León-Muinos, Daniel González-Vilas, Óscar Suárez-Amor
Clindamycin is a lincomycin-derived antibiotic useful for the treatment of anaerobic and Gram-positive aerobic bacterial infections. Cutaneous adverse reactions are usually maculopapular exanthemas, although hypersensitivity syndrome, acute generalized exanthematous pustulosis, and Stevens-Johnson syndrome have also been reported (1). We report the case of a patient with a maculopapular rash triggered by clindamycin who developed cutaneous lesions on striae distensae (SD). A 47-year-old woman was referred to our clinic for pruritic cutaneous lesions which had started 6 days earlier...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29782037/multiloculated-solitary-unicameral-bone-cyst-in-a-young-dog
#14
Sarah C Roode, Heather R Shive, Willemijn Hoorntje, Jennifer Bernard, Devorah M Stowe, Roy R Pool, Carol B Grindem
A 20-month-old female spayed Staffordshire Terrier (22.3 kg) presented to the Orthopedic Surgery Service at North Carolina State University Veterinary Teaching Hospital for evaluation of a 6-week history of toe-touching to nonweight-bearing lameness in the right hind limb. Radiographs of the right stifle revealed a multiloculated lytic lesion of the distal femur, with a large open lytic zone centrally, numerous osseous septations peripherally, and focal areas of cortical thinning and loss. An aspirate of the right distal femoral lesion yielded mildly cloudy serosanguineous fluid...
May 21, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/29781992/muscle-imbalances-testing-and-training-functional-eccentric-hamstring-strength-in-athletic-populations
#15
Petr Stastny, Michal Lehnert, James J Tufano
Many hamstring injuries that occur during physical activity occur while the muscles are lengthening, during eccentric hamstring muscle actions. Opposite of these eccentric hamstring actions are concentric quadriceps actions, where the larger and likely stronger quadriceps straighten the knee. Therefore, to stabilize the lower limbs during movement, the hamstrings must eccentrically combat against the strong knee-straightening torque of the quadriceps. As such, eccentric hamstring strength expressed relative to concentric quadricep strength is commonly referred to as the "functional ratio" as most movements in sports require simultaneous concentric knee extension and eccentric knee flexion...
May 1, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29781963/comorbidities-and-mobility-in-lower-limb-prosthesis-users
#16
Shane R Wurdeman, Phillip M Stevens, James H Campbell
OBJECTIVE: To determine the impact of comorbidities on mobility in patients with lower limb prostheses. DESIGN: Cohort database chart review examining mobility in lower limb prosthesis users grouped according to comorbidities. Regression models were used to determine significant predictor comorbidities for mobility. General linear univariate models were implemented to investigate differences in mobility among cohorts (n=596). RESULTS: Patient age and history of stroke, peripheral vascular disease, and anxiety/panic disorders were predictors of decreased mobility...
May 17, 2018: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29781960/a-peripherally-restricted-cannabinoid-1-receptor-agonist-as-a-novel-analgesic-in-cancer-induced-bone-pain
#17
Hong Zhang, Dominique M Lund, Haley A Ciccone, William D Staatz, Mohab M Ibrahim, Tally M Largent-Milnes, Herbert H Seltzman, Igor Spigelman, Todd W Vanderah
Many malignant cancers, including breast cancer, have a propensity to invade bones, leading to excruciating bone pain. Opioids are the primary analgesics used to alleviate this cancer-induced bone pain (CIBP) but are associated with numerous severe side effects, including enhanced bone degradation, which significantly impairs patients' quality of life. In contrast, agonists activating only peripheral CB1 receptors (CB1Rs) have been shown to effectively alleviate multiple chronic pain conditions with limited side effects, yet no studies have evaluated their role(s) in CIBP...
May 16, 2018: Pain
https://www.readbyqxmd.com/read/29781949/optn-vascularized-composite-allograft-vca-waiting-list-current-status-and-trends-in-the-united-states
#18
Jennifer L Wainright, Christopher L Wholley, Wida S Cherikh, Jennifer M Musick, David K Klassen
BACKGROUND: Vascularized Composite Allograft (VCA) transplantation is a developing area in the field of transplantation. METHODS: This study used Organ Procurement and Transplantation Network (OPTN) VCA waiting list and transplant data from July 3, 2014 through February 28, 2018 to characterize the OPTN VCA waiting list in terms of composition, removal patterns, waiting time, resulting transplants, and trends over time. RESULTS: Between implementation of the OPTN VCA waiting list on July 3, 2014 and February 28, 2018, 54 candidates - 53...
April 30, 2018: Transplantation
https://www.readbyqxmd.com/read/29781902/endovenous-thermal-ablation-of-recurrent-varicose-veins-due-to-residual-great-saphenous-venous-insufficiency-after-saphenous-venous-surgery-a-comparative-study
#19
Jin Ho Hwang, Sang Woo Park, Il Soo Chang, Ki Hyun Kim, Ji Hun Kang
BACKGROUND: Redo surgery for recurrent varicose veins of the great saphenous vein (GSV) is technically more challenging than the initial surgery. OBJECTIVE: To compare 980 and 1,470-nm endovenous laser ablation (EVLA) and radiofrequency ablation (RFA) for the treatment of residual GSV insufficiency after saphenofemoral ligation ± stripping. MATERIALS AND METHODS: Thirty-seven limbs in 29 patients with recurrent varicose veins were retrospectively evaluated...
May 16, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29781550/walking-gait-asymmetries-six-months-following-anterior-cruciate-ligament-reconstruction-predict-twelve-month-patient-reported-outcomes
#20
Brian Pietrosimone, J Troy Blackburn, Darin A Padua, Steven J Pfeiffer, Hope C Davis, Brittney A Luc-Harkey, Matthew S Harkey, Laura E Stanley, Barnett S Frank, R Alexander Creighton, Ganesh M Kamath, Jeffery T Spang
The study sought to determine the association between gait biomechanics (vertical ground reaction force [vGRF], vGRF loading rate [vGRF-LR]) collected six months following anterior cruciate ligament reconstruction (ACLR) with patient-reported outcomes at twelve months following ACLR. Walking gait mechanics and all subsections of the Knee Injury and Osteoarthritis Outcomes Score (KOOS) were collected at six and twelve months following ACLR, respectively, in 25 individuals with a unilateral ACLR. Peak vGRF and peak instantaneous vGRF-LR were extracted from the first 50% of the stance phase...
May 21, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
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