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Multiple sclerosis depression

Volkan Solmaz, Hatice Kose Ozlece, Aydın Him, Ayfer Güneş, Christian Cordano, Durdane Aksoy, Yahya Çelik
Purpose To investigate the frequency of sexual dysfunction (SD) in female multiple sclerosis (MS) patients and to explore its association with the location and number of demyelinating lesions. Material and Methods We evaluated 42 female patients and 41 healthy subjects. All patients underwent neurological examination and 1.5 T brain and full spinal MRI. All subjects completed the female sexual function index (FSFI), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), and Short-Form 36 Quality of Life Scale (SF-36)...
April 17, 2018: Neurological Research
Judith Dianne Pugh, Kathleen McCoy, Anne M Williams, Brenda Bentley, Leanne Monterosso
Neurological conditions represent leading causes of non-fatal burden of disease that will consume a large proportion of projected healthcare expenditure. Inconsistent access to integrated healthcare and other services for people with long-term neurological conditions stresses acute care services. The purpose of this rapid evidence assessment, conducted February-June 2016, was to review the evidence supporting community neurological nursing approaches for patients with neurological conditions post-discharge from acute care hospitals...
April 16, 2018: Health & Social Care in the Community
Raggi Alberto, Ambra Mara Giovannetti, Silvia Schiavolin, Laura Brambilla, Greta Brenna, Paolo Agostino Confalonieri, Francesca Cortese, Rita Frangiamore, Matilde Leonardi, Renato Emilio Mantegazza, Marco Moscatelli, Michela Ponzio, Valentina Torri Clerici, Paola Zaratin, Laura De Torres
PURPOSE: This cross-sectional study aims to identify the predictors of work-related difficulties in a sample of employed persons with multiple sclerosis as addressed with the Multiple Sclerosis Questionnaire for Job Difficulties. MATERIALS AND METHODS: Hierarchical linear regression analysis was conducted to identify predictors of work difficulties: predictors included demographic variables (age, formal education), disease duration and severity, perceived disability and psychological variables (cognitive dysfunction, depression and anxiety)...
April 16, 2018: Disability and Rehabilitation
Pamela Newland, John M Newland, Verna L Hendricks-Ferguson, Judith M Smith, Brant J Oliver
PURPOSE: The purpose of this article was to demonstrate the feasibility of using common data elements (CDEs) to search for information on the pediatric patient with multiple sclerosis (MS) and provide recommendations for future quality improvement and research in the use of CDEs for pediatric MS symptom management strategies Methods: The St. Louis Children's Hospital (SLCH), Washington University (WU) pediatrics data network was evaluated for use of CDEs identified from a database to identify variables in pediatric MS, including the key clinical features from the disease course of MS...
April 12, 2018: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
Yolanda Rebeca Peñaloza López, Xóchitl Daisy Orozco Peña, Santiago Jesús Pérez Ruiz
OBJECTIVE: To evaluate the central auditory processing disorders in patients with multiple sclerosis, emphasizing auditory laterality by applying psychoacoustic tests and to identify their relationship with the Multiple Sclerosis Disability Scale (EDSS) functions. METHOD: Depression scales (HADS), EDSS, and 9 psychoacoustic tests to study CAPD were applied to 26 individuals with multiple sclerosis and 26 controls. Correlation tests were performed between the EDSS and psychoacoustic tests...
April 3, 2018: Acta Otorrinolaringológica Española
Taoufik Alsaadi, Khadija El Hammasi, Tarek M Shahrour, Mustafa Shakra, Lamya Turkawi, Wassim Nasreddine, Seada Kassie, Mufeed Raoof
To study the impact of depression and anxiety on health-related quality of life (HRQOL) in patients with multiple sclerosis (pwMS) in the UAE. All consecutive patients attending the MS clinic over a fourmonth period, October 2014 through February 2015, at Sheikh Khalifa Medical city (SKMC) were asked to complete The World Health Organization quality of life abbreviated scale (WHOQOL-BREF), the Patient Health Questionnaire nine-item (PHQ-9) depression scale, and Generalized Anxiety Disorder seven-item (GAD-7) scale...
December 11, 2017: Neurology International
Stephen D Skaper, Laura Facci, Morena Zusso, Pietro Giusti
Inflammation is a complex biological response fundamental to how the body deals with injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a normally beneficial acute inflammatory response, chronic inflammation can lead to tissue damage and ultimately its destruction, and often results from an inappropriate immune response. Inflammation in the nervous system ("neuroinflammation"), especially when prolonged, can be particularly injurious. While inflammation per se may not cause disease, it contributes importantly to disease pathogenesis across both the peripheral (neuropathic pain, fibromyalgia) and central [e...
2018: Frontiers in Cellular Neuroscience
Dessislava Iancheva, Anastasiya G Trenova, Kiril Terziyski, Sevdalina Kandilarova, Stefka Mantarova
RATIONALE, AIMS, AND OBJECTIVES: Paced Auditory Serial Addition Test (PASAT) is used for assessment of information processing speed, attention, and working memory, which are the most frequently affected cognitive domains in multiple sclerosis (MS) patients, and may be significantly affected by fatigue. However, the effect of fatigue and mood on the PASAT performance in MS patients translationally validated by fMRI has not been studied yet. The aim of this study is to investigate the translational validity of the PASAT, using fMRI during a paced visual serial addition test (PVSAT) paradigm in patients with relapsing remitting MS (RRMS) and to assess the impact of fatigue and mood on test performance...
April 3, 2018: Journal of Evaluation in Clinical Practice
Elizabeth Morghen Sikes, Robert W Motl, Jayne M Ness
Purpose: Pediatric-onset multiple sclerosis (POMS) accounts for ~5% of all multiple sclerosis cases, and has a prevalence of ~10,000 children in the USA. POMS is associated with a higher relapse rate, and results in irreversible disability on average 10 years earlier than adult-onset multiple sclerosis. Other manifestations of POMS include mental and physical fatigue, cognitive impairment, and depression. We believe that the health behaviors of physical activity, diet, and sleep may have potential benefits in POMS, and present a scoping review of the existing literature...
2018: Pediatric Health, Medicine and Therapeutics
Melody N Mickens, Paul B Perrin, Adriana Aguayo, Brenda Rabago, Miguel A Macías-Islas, Juan Carlos Arango-Lasprilla
Individuals with multiple sclerosis (MS), especially those living in Latin America, often require assistance from family caregivers throughout the duration of the disease. Previous research suggests that family caregivers may experience positive and negative outcomes from providing care to individuals with MS, but few studies have examined the unmet needs of individuals providing care to family members with MS and how these unmet needs may mediate the relationship between MS symptoms and caregiver mental health...
2018: Behavioural Neurology
Quinten van Geest, Rosa E Boeschoten, Matthijs J Keijzer, Martijn D Steenwijk, Petra Jw Pouwels, Jos Wr Twisk, Johannes H Smit, Bernard Mj Uitdehaag, Jeroen Jg Geurts, Patricia van Oppen, Hanneke E Hulst
BACKGROUND: The biological mechanism of depression in multiple sclerosis (MS) is not well understood. Based on work in major depressive disorder, fronto-limbic disconnection might be important. OBJECTIVE: To investigate structural and functional fronto-limbic changes in depressed MS (DMS) and non-depressed MS (nDMS) patients. METHODS: In this retrospective study, 22 moderate-to-severe DMS patients (disease duration 8.2 ± 7.7 years), 21 nDMS patients (disease duration 15...
March 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
Adele C Viguera, Youran Fan, Nicolas R Thompson, Brittany Lapin, Alexander Chaitoff, Sandra D Griffith, Deborah M Miller, Lara Jehi, Irene L Katzan
BACKGROUND: Neurological conditions carry a high risk of depression. Given this risk, the Neurological Institute (NI) at Cleveland Clinic has initiated systematic screening for depression using the 9-item Patient Health Questionnaire-9 (PHQ-9) embedded within its electronic medical record and its data capture system, the Knowledge Program (KP)1 . OBJECTIVE: We sought to (1) estimate the prevalence of depression among patients with epilepsy, stroke, and multiple sclerosis (MS); (2) identify risk factors for depression within each disease; and (3) determine differential risks and predictors across neurological disorders...
December 13, 2017: Psychosomatics
Christoforos D Giannaki, Panagiotis Aristotelous, Manos Stefanakis, Georgios M Hadjigeorgiou, Mauro Manconi, Eleni Leonidou, Giorgos K Sakkas, Marios Pantzaris
Objectives Restless legs syndrome (RLS) symptoms are common in Multiple Sclerosis (MS) patients. The aim of the current study was to examine for the first time whether RLS could affect the functional capacity and various contributing parameters related to quality of life and fatigue in MS patients. Methods According to their RLS status, 50 relapsing-remitting MS patients were divided into the RLS (n = 10) and non-RLS groups (n = 40). Specific questionnaires were used in order to assess the health-related quality of life (HRQoL), fatigue levels, sleep quality, daily sleepiness, and depression symptoms of the patients...
March 26, 2018: Neurological Research
Katerina Ntoskou, Lambros Messinis, Grigorios Nasios, Maria Martzoukou, Giorgos Makris, Elias Panagiotopoulos, Panagiotis Papathanasopoulos
Objective: The objective of this study was to investigate the pattern and severity of cognitive and language impairment in Greek patients with Relapsing-remitting (RRMS) and Secondary Progressive Multiple Sclerosis (SPMS), relative to control participants. Method: A prospective study was conducted in 27 patients with multiple sclerosis (PwMS), ( N = 15) with RRMS, ( N = 12) with SPMS, and ( N = 12) healthy controls. All participants were assessed with a flexible comprehensive neuropsychological - language battery of tests that have been standardized in Greece and validated in Greek MS patients...
2018: Open Neurology Journal
Farhat Husain, Gabriel Pardo, Meheroz Rabadi
PURPOSE OF REVIEW: The purpose of this review was to discuss the prevalence, impact, pathophysiology, and treatment of headaches (H/As) in patients with multiple sclerosis (MS). RECENT FINDINGS: Headaches and multiple sclerosis are more common in women than in men with the ratio of female to male being 3:1. It is not entirely clear if there is a correlation or an incidental comorbidity of two neurological conditions. A review of the literature shows a variable prevalence of H/As in MS patients...
March 24, 2018: Current Treatment Options in Neurology
Arianna Rinaldi, Francesco Zaghini, Alessandro Sili
AIM: The main objective of the study was to measure caregiver burden among informal caregivers assisting people with multiple sclerosis (MS). BACKGROUND: Thirty percent of people with multiple sclerosis require some form of home assistance and 80% of such care is provided by informal caregivers. The quality of life of informal caregivers of patients with multiple sclerosis decreases with increasing physical and depressive symptoms of their loved ones. This can have effects on stress levels, physical and mental health, quality of life, and mortality of informal caregivers...
November 2017: Igiene e Sanità Pubblica
Ipek Ensari, Julia M Balto, Elizabeth A Hubbard, Lara A Pilutti, Robert W Motl
OBJECTIVE: There is evidence that motor and cognitive impairments often co-occur in multiple sclerosis (MS). There is little research on influences of cognitive-motor coupling, particularly depressive symptoms. This study examined depressive symptoms as a moderator and/or confounder of cognitive-motor coupling in persons with MS. METHOD: The sample included 131 persons with MS who were allocated into elevated and nonelevated depressive symptom groups based on a cutoff score of 8 on the Hospital Anxiety Depression Scale...
February 2018: Rehabilitation Psychology
Blathin Casey, Marcin Uszynski, Sara Hayes, Robert Motl, Stephen Gallagher, Susan Coote
OBJECTIVE: To investigate the bivariate correlations between objective physical activity (PA), self-efficacy, and a range of multiple sclerosis (MS) symptom measures. Also, to determine whether any MS symptom measures moderate the relationship between self-efficacy and PA. METHOD: Baseline analysis from a randomized control trial exercise plus a behavior change intervention was used. Fifty-nine physically inactive people with a definite diagnosis of MS were included...
February 2018: Rehabilitation Psychology
Barnaby J Proctor, Nima Moghaddam, William Vogt, Roshan das Nair
OBJECTIVE: The objective of the study was to review the evidence for the effectiveness of telephone psychotherapy on psychological outcomes in people with multiple sclerosis (MS). METHOD: We conducted a systematic search of EMBASE, PsycINFO, PsycARTICLES, MEDLINE, CINAHL, Web of Science, and hand-searched relevant journals to identify randomized controlled trials (RCTs) that evaluated the effectiveness of telephone psychotherapy on psychological outcomes in people with MS (last search completed on October 1, 2015)...
February 2018: Rehabilitation Psychology
Changqing Lu, Lihua Dong, Hui Zhou, Qianmei Li, Guojiao Huang, Shu Jun Bai, Linchuan Liao
Oligodendrocytes are the myelin-producing cells of the central nervous system (CNS). A variety of brain disorders from "classical" demyelinating diseases, such as multiple sclerosis, stroke, schizophrenia, depression, Down syndrome and autism, are shown myelination defects. Oligodendrocyte myelination is regulated by a complex interplay of intrinsic, epigenetic and extrinsic factors. Gpr17 (G protein-coupled receptor 17) is a G protein-coupled receptor, and has been identified to be a regulator for oligodendrocyte development...
March 14, 2018: Scientific Reports
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