keyword
https://read.qxmd.com/read/38541102/risk-factors-for-psychiatric-disorders-in-patients-with-multiple-sclerosis-a-single-center-study-in-the-polish-population
#1
JOURNAL ARTICLE
Hubert Mado, Michał Błachut, Anna Szczegielniak, Krzysztof Świerzy, Magdalena Zając, Katarzyna Kubicka-Bączyk, Piotr Gorczyca, Monika Adamczyk-Sowa
Aim : The aim of this study was to determine the prevalence of mental disorders in a group of patients with multiple sclerosis (MS) during outpatient treatment. Additionally, an attempt was made to assess the influence of parameters related to patients and their clinical status on the prevalence of mental disorders. Materials and Methods : This study was conducted between 2017 and 2018 in a group of 103 patients with MS who underwent treatment at the Outpatient Clinic of Neurology at the Clinical Hospital No...
February 23, 2024: Medicina
https://read.qxmd.com/read/38530606/rebistart-adherence-of-patients-with-multiple-sclerosis-to-treatment-with-subcutaneous-interferon-beta-in-the-context-of-a-patient-support-program
#2
JOURNAL ARTICLE
Matthias Schwab, Andrew Chan, Anna-Katharina Eser, Boris Kallmann, Dieter Pöhlau, Joachim Richter, Torsten B Wagner, Christoph Grothe
INTRODUCTION: Treatment adherence is a critical success factor in the disease-modifying therapy (DMT) of multiple sclerosis (MS). The REBISTART study prospectively evaluated adherence in patients using components of a patient support program (PSP). METHODS: The 12-month non-interventional multicenter study examined the real-world adherence to subcutaneously (sc) injected interferon beta-1a (Rebif® ). Patient-assessed adherence was measured by a visual analog scale (VAS) and the Morisky Medication Adherence Scale (MMAS)...
March 26, 2024: Neurology and Therapy
https://read.qxmd.com/read/38528018/treatment-satisfaction-with-disease-modifying-therapy-is-the-only-predictor-of-adherence-among-multiple-sclerosis-patients-from-upper-egypt
#3
JOURNAL ARTICLE
Eman M Khedr, Doaa M Mahmoud, Hussein B Hussein, Islam E L Malky, Sarah S Mostafa, Ayman Gamea
Despite the proven efficacy of the disease-modifying therapy (DMT) for multiple sclerosis (MS), the rates of non-adherence are frequently high. We aimed to evaluate the rate of non-adherence to the first DMT in Upper Egypt and identify different contributing factors. Out of 310 patients, ninety-seven adult patients with RRMS were recruited from three MS units located in Upper Egypt and were subjected to the following: complete clinical history, expanded disability status score (EDSS), Eight-item Morisky Medication Adherence Scale (MMAS-8), abbreviated Treatment Satisfaction Questionnaire for Medication-9 (TSQM-9), Hamilton depression scale, Fatigue Severity Scale (FSS) and the Pittsburgh Sleep Quality Index (PSQI)...
March 25, 2024: Scientific Reports
https://read.qxmd.com/read/38528009/a-systematic-review-and-meta-analysis-of-socio-cognitive-impairments-in-multiple-sclerose
#4
JOURNAL ARTICLE
Mandy Roheger, Lydia Grothe, Laura Hasselberg, Matthias Grothe, Marcus Meinzer
Socio-cognitive impairment is frequent in multiple sclerosis (MS). However, little is known about the relationship between other potentially relevant clinical symptoms (i.e., cognition, depression, fatigue) and the degree of socio-cognitive impairment, and neural mechanisms underlying socio-cognitive deficits in MS. Therefore, we meta-analytically quantified socio-cognitive impairment in MS. A systematic literature search in MEDLINE Ovid, Web of Science Core Collection, CENTRAL, and PsycInfo was conducted until December 2022...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38524897/viewpoints-sigma-1-receptor-agonist-fluvoxamine-for-multiple-sclerosis
#5
REVIEW
Kenji Hashimoto
Accumulating evidence suggests that the Epstein-Barr virus (EBV) plays a key role in the development of multiple sclerosis (MS). Additionally, depressive symptoms often precede the onset of MS. Given the role of the XBP1-sigma-1 receptor complex in the endoplasmic reticulum during EBV reactivation, the author proposes that fluvoxamine, an antidepressant with sigma-1 receptor agonism, could be a suitable therapeutic drug for MS.
May 2024: Brain, behavior, & immunity health
https://read.qxmd.com/read/38507968/the-association-of-resilience-and-positive-mental-health-in-systemic-sclerosis-a-scleroderma-patient-centered-intervention-network-spin-cohort-cross-sectional-study
#6
JOURNAL ARTICLE
Marieke A Neyer, Richard S Henry, Marie-Eve Carrier, Linda Kwakkenbos, Gabrielle Virgili-Gervais, Robyn K Wojeck, Amanda Wurz, Amy Gietzen, Karen Gottesman, Geneviève Guillot, Amanda Lawrie-Jones, Maureen D Mayes, Luc Mouthon, Warren R Nielson, Michelle Richard, Maureen Sauvé, Daphna Harel, Vanessa L Malcarne, Susan J Bartlett, Andrea Benedetti, Brett D Thombs
OBJECTIVE: A previous study using Scleroderma Patient-centered Intervention Network (SPIN) Cohort data identified five classes of people with systemic sclerosis (also known as scleroderma) based on patient-reported somatic (fatigue, pain, sleep) and mental health (anxiety, depression) symptoms and compared indicators of disease severity between classes. Across four classes ("low", "normal", "high", "very high"), there were progressively worse somatic and mental health outcomes and greater disease severity...
March 11, 2024: Journal of Psychosomatic Research
https://read.qxmd.com/read/38500270/the-presence-and-burden-of-cognitive-issues-discordance-between-the-perception-of-neurologists-and-people-living-with-multiple-sclerosis
#7
JOURNAL ARTICLE
Iris-Katharina Penner, Virginia De Las Heras, Eddie Jones, Suzannah Hetherington, Himanshu Karu, Rahul Chetlangia, Sourav Biswas, Patricia Dominguez Castro, Carol Lines
BACKGROUND AND PURPOSE: Cognitive impairment is a common symptom of multiple sclerosis (MS) and occurs in more than 40% of people living with MS (plwMS). No real-world study has assessed the perception of neurologists and plwMS on cognitive issues. METHODS: Using data from the 2011-2019 Adelphi MS Disease Specific Programme database, this real-world, retrospective, cross-sectional multi-cohort study included people aged ≥18 years with relapsing-remitting MS and secondary progressive MS from the United States, UK and the EU...
March 18, 2024: European Journal of Neurology
https://read.qxmd.com/read/38498024/exploring-the-major-barriers-to-physical-activity-in-persons-with-multiple-sclerosis-observational-longitudinal-study
#8
JOURNAL ARTICLE
Chloé Sieber, Christina Haag, Ashley Polhemus, Sarah R Haile, Ramona Sylvester, Jan Kool, Roman Gonzenbach, Viktor von Wyl
BACKGROUND: Physical activity (PA) represents a low-cost and readily available means of mitigating multiple sclerosis (MS) symptoms and alleviating the disease course. Nevertheless, persons with MS engage in lower levels of PA than the general population. OBJECTIVE: This study aims to enhance the understanding of the barriers to PA engagement in persons with MS and to evaluate the applicability of the Barriers to Health Promoting Activities for Disabled Persons (BHADP) scale for assessing barriers to PA in persons with MS, by comparing the BHADP score with self-reported outcomes of fatigue, depression, self-efficacy, and health-related quality of life, as well as sensor-measured PA...
March 18, 2024: JMIR Rehabilitation and Assistive Technologies
https://read.qxmd.com/read/38492318/characteristics-and-predictors-of-sexual-dysfunction-in-men-with-multiple-sclerosis
#9
JOURNAL ARTICLE
Ivan Adamec, Tomislav Sambolić, Mihovil Santini, Antea Karić, Anamari Junaković, Barbara Barun, Tereza Gabelić, Luka Crnošija, Magdalena Krbot Skorić, Mario Habek
PURPOSE: To validate and culturally adapt the Sexual Health Inventory for Men (IIEF-5) and the Premature Ejaculation Diagnostic Tool (PEDT), to compare the frequency and severity of erectile dysfunction (ED) and premature ejaculation (PE) in male individuals with MS (mwMS) in comparison with healthy controls (HC) and to investigate predictors of the severity of ED and PE in mwMS. METHODS: 216 consecutive mwMS and 37 HC completed IIEF-5 and PEDT. Additionally, 114 mwMS completed the Modified Fatigue Impact Scale (MFIS), Beck Depression Inventory (BDI-2), Composite Autonomic System Score-31 (COMPASS-31), and the 5-level EQ-5D questionnaire...
March 5, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38488827/a-closed-loop-digital-health-tool-to-improve-depression-care-in-multiple-sclerosis-iterative-design-and-cross-sectional-pilot-randomized-controlled-trial-and-its-impact-on-depression-care
#10
JOURNAL ARTICLE
Kyra Henderson, Jennifer Reihm, Kanishka Koshal, Jaeleene Wijangco, Narender Sara, Nicolette Miller, Marianne Doyle, Alicia Mallory, Judith Sheridan, Chu-Yueh Guo, Lauren Oommen, Katherine P Rankin, Stephan Sanders, Anthony Feinstein, Christina Mangurian, Riley Bove
BACKGROUND: People living with multiple sclerosis (MS) face a higher likelihood of being diagnosed with a depressive disorder than the general population. Although many low-cost screening tools and evidence-based interventions exist, depression in people living with MS is underreported, underascertained by clinicians, and undertreated. OBJECTIVE: This study aims to design a closed-loop tool to improve depression care for these patients. It would support regular depression screening, tie into the point of care, and support shared decision-making and comprehensive follow-up...
March 15, 2024: JMIR Formative Research
https://read.qxmd.com/read/38486131/quantifying-the-need-for-specialist-palliative-care-management-in-systemic-sclerosis
#11
JOURNAL ARTICLE
Laura Ross, Julie McDonald, Dylan Hansen, Jessica Fairley, Carolyn Wicks, Susanna Proudman, Jennifer Walker, Joanne Sahhar, Gene-Siew Ngian, Lauren Host, Wendy Stevens, Jennifer Philip, Mandana Nikpour
OBJECTIVE: The importance of early integration of palliative care in the management of complex multi-system diseases has been recognised. In this study, we aimed to quantify the need for specialist palliative care in systemic sclerosis (SSc). METHODS: Using data from 875 patients enrolled in the Australian Scleroderma Cohort Study, we defined need for palliative care as a high symptom burden at ≥2 consecutive study visits, ≥50% of overall study visits or at the study visit immediately prior to death...
March 14, 2024: Arthritis Care & Research
https://read.qxmd.com/read/38481946/factors-affecting-driving-performance-in-patients-with-multiple-sclerosis-still-an-open-question
#12
JOURNAL ARTICLE
Susan Seddiq Zai, Roshan das Nair, Christoph Heesen, Carsten Buhmann, Anya Pedersen, Jana Pöttgen
BACKGROUND AND OBJECTIVES: Research on driving ability in people with multiple sclerosis (MS) suggests that they might be at risk for unsafe driving due to MS-related motor, visual, and cognitive impairment. Our first aim was to investigate differences in driving ability and performance between people with MS (PwMS) and those without any neurologic or psychiatric disease ("controls"). Secondly, we determined disease-related factors influencing driving ability in PwMS. METHODS: We prospectively compared standardized performance in a driving simulator between 97 persons with early MS [mean (SD) = 6...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38475891/multiple-sclerosis-and-personality-traits-associations-with-depression-and-anxiety
#13
JOURNAL ARTICLE
Saeed Vaheb, Yousef Mokary, Mohammad Yazdan Panah, Aysa Shaygannejad, Alireza Afshari-Safavi, Majid Ghasemi, Vahid Shaygannejad, Elham Moases Ghaffary, Omid Mirmosayyeb
BACKGROUND: Depression and anxiety are commonly observed in people with multiple sclerosis (pwMS). There is a growing body of literature supporting the hypothesis that personality traits can influence the mood disorders. This study aimed to investigate the personality traits and their relationships with depression and anxiety among pwMS. METHODS: 234 pwMS were involved in this cross-sectional study. Personality traits, depression, and anxiety were assessed using the NEO Five-Factor Inventory (NEO-FFI) and Hospital Anxiety and Depression Scale (HADS), respectively...
March 12, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38466080/therapeutic-effects-of-line-dancing-in-people-with-multiple-sclerosis-an-evaluator-blinded-randomized-controlled-study
#14
JOURNAL ARTICLE
Sultan Baştürk, Gamze Ekici, Fatoş Kırteke, Ömer Faruk Durak, Berkay Ekici
BACKGROUND: Line dancing is a popular form of exercise shown to affect balance and mood positively. However, few studies examine its effectiveness in multiple sclerosis (MS). The study aims to investigate the effects of line dancing on balance, mood, and health-related quality of life in MS. METHODS: Participants were randomized into the line dance ( n =15) and the control groups ( n =16). Outcomes were measured using the Berg Balance Scale, Hospital Anxiety and Depression Scale, and Multiple Sclerosis Quality of Life-54 (MSQoL-54) at baseline and post intervention...
March 11, 2024: Arts & Health
https://read.qxmd.com/read/38462980/adaptation-and-validation-of-the-greek-version-of-the-communication-and-language-assessment-questionnaire-for-persons-with-multiple-sclerosis-clams
#15
JOURNAL ARTICLE
Nefeli Dimitriou, Grigorios Nasios, Anastasia Nousia, Emmanouil Anyfantis, Lambros Messinis, Georgios Dimakopoulos, Sarah El-Wahsh, Christos Bakirtzis, Vasiliki Kostadima, Spiridon Konitsiotis
OBJECTIVE: The aim of the present study was to validate the Communication and Language Assessment questionnaire for persons with Multiple Sclerosis (CLAMS) into the Greek language. METHOD: 106 Persons with Multiple Sclerosis (PwMS) and 51 healthy controls (HCs) participated in this study. We evaluated patients' cognitive abilities with the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS). All PwMS completed the CLAMS and three additional questionnaires (Speech Pathology-Specific Questionnaire for persons with Multiple Sclerosis, SMS; Stroke and Aphasia Quality of Life Scale-39, SAQOL-39; the Beck Depression Inventory Fast Screen, BDI-FS), and all HCs filled in the CLAMS...
March 9, 2024: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://read.qxmd.com/read/38460992/cognitive-rehabilitation-program-in-patients-with-multiple-sclerosis-a-pilot-study
#16
JOURNAL ARTICLE
R M Jiménez-Morales, Y Broche-Pérez, Y Macías-Delgado, C Sebrango, S Díaz-Díaz, R Castiñeira-Rodriguez, F J Pérez-González, C Forn
INTRODUCTION: In recent years, there has been an increase of studies dedicated to cognitive rehabilitation in patients with multiple sclerosis (MS); however, few of these analyze the impact on such variables as cognitive reserve. The study aims to explore the effects of a cognitive rehabilitation program comprising a combination of cognitive and physical exercises, as well as group sessions to improve cognitive performance, emotional state, and cognitive reserve index. METHOD: Fifty patients with MS were subdivided into 2 groups: the control group, which performed aerobic exercise (n=25), and the experimental group (n=25), which participated in the integrated cognitive rehabilitation program (ICRP)...
March 2024: Neurología
https://read.qxmd.com/read/38454906/neuroimaging-and-neuromodulation-of-invisible-symptoms-in-multiple-sclerosis
#17
JOURNAL ARTICLE
Samar S Ayache, Moussa A Chalah
No abstract text is available yet for this article.
2024: Frontiers in Human Neuroscience
https://read.qxmd.com/read/38436164/does-anxiety-depression-and-sleep-levels-affect-the-quality-of-life-in-patients-diagnosed-with-multiple-sclerosis
#18
JOURNAL ARTICLE
S Dogan, S Yildiz, A Kazgan Kılıçaslan, B Sirlier Emir, O Kurt, S Sehlikoğlu
OBJECTIVE: Multiple sclerosis (MS) is a chronic disease characterized by relapses and remissions, causing physical disability and affecting individuals psychosocially. In this study, we aimed to assess anxiety and depression levels, sleep, and quality of life in MS patients. PATIENTS AND METHODS: The study included 66 participants, 30 healthy controls, and 36 patients diagnosed with MS. All participants were administered the Sociodemographic and Clinical Data Form, Multiple Sclerosis Quality of Life Instrument (MSQOL-54), Pittsburgh Sleep Quality Index (PSQI), Expanded Disability Status Scale (EDSS), Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI)...
February 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38426484/prevalence-and-associated-clinical-characteristics-of-walking-related-motor-cognitive-and-fatigability-in-progressive-multiple-sclerosis-baseline-results-from-the-cogex-study
#19
JOURNAL ARTICLE
Cintia Ramari, Mieke D'hooge, Ulrik Dalgas, Anthony Feinstein, Maria Pia Amato, Giampaolo Brichetto, Jeremy Chataway, Nancy D Chiaravalloti, Gary R Cutter, John DeLuca, Rachel Farrell, Massimo Filippi, Jennifer Freeman, Matilde Inglese, Cecilia Meza, Robert W Motl, Maria A Rocca, Brian M Sandroff, Amber Salter, Daphne Kos, Peter Feys
BACKGROUND: People with progressive multiple sclerosis (PMS) present motor (eg, walking) and cognitive impairments, and report fatigue. Fatigue encompasses fatigability which is objectively measured by the capacity to sustain a motor or cognitive task. OBJECTIVE: To investigate the prevalence of walking and cognitive fatigability (CF) and the associated clinical characteristics in a large sample of PMS patients. METHODS: PMS patients (25-65 years old) were included from 11 sites (Europe and North America), having cognitive impairment (1...
March 1, 2024: Neurorehabilitation and Neural Repair
https://read.qxmd.com/read/38425686/exercise-based-gaming-in-patients-with-multiple-sclerosis-a-systematic-review-and-meta-analysis
#20
REVIEW
Amal Mohamed Elhusein, Hammad Ali Fadlalmola, Eltayeb Mohammed Awadalkareem, Ekram Yahia Mahmowd Alhusain, Soad Mohamed Alnassry, Mukhlid Alshammari, Elsadig Eltahir Abdulrahman, Doaa El Sayed Fadila, Fatma M Ibrahim, Abdalrahman Abdallatif Mohmmed Saeed, Adel Abdalla, Hassan N Moafa, Ehab I El-Amin, Daniel Mon Mamanao
BACKGROUND: Multiple sclerosis presents a significant burden, with balance disturbances impacting patients' daily living. Conventional therapies have been supplemented with technological advancements like virtual reality (VR) and exergaming, providing engaging, multisensory rehabilitation options. OBJECTIVE: This study aimed to synthesize evidence on exergaming's role in multiple sclerosis treatment, particularly to evaluate the impact of exergaming on cognitive, motor, and psychological outcomes in patients with multiple sclerosis...
2024: Belitung nursing journal
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