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https://www.readbyqxmd.com/read/28340237/pain-and-cognition-in-multiple-sclerosis
#1
R Scherder, N Kant, E Wolf, A C M Pijnenburg, E Scherder
Objective. : The goal of the present study was to examine the relationship between pain and cognition in patients with multiple sclerosis. Design. : Cross-sectional. Setting. : Nursing home and personal environment of the investigators. Subjects. : Two groups of participants were included: 91 patients with multiple sclerosis and 80 matched control participants. Methods. : The level of pain was measured by the following pain scales: Number of Words Chosen-Affective, Colored Analogue Scale for pain intensity and suffering from pain, and the Faces Pain Scale...
March 15, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28332703/predictors-of-meaningful-improvement-in-quality-of-life-after-temporal-lobe-epilepsy-surgery-a-prospective-study
#2
Carla Pauli, Marcelo Liborio Schwarzbold, Alexandre Paim Diaz, Maria Emilia Rodrigues de Oliveira Thais, Charles Kondageski, Marcelo Neves Linhares, Ricardo Guarnieri, Bianca de Lemos Zingano, Juliana Ben, Jean Costa Nunes, Hans Joachim Markowitsch, Peter Wolf, Samuel Wiebe, Katia Lin, Roger Walz
OBJECTIVES: To investigate prospectively the independent predictors of a minimum clinically important change (MCIC) in quality of life (QOL) after anterior temporal lobectomy (ATL) for drug-resistant mesial temporal lobe epilepsy related to hippocampal sclerosis (MTLE-HS) in Brazilian patients. METHODS: Multiple binary logistic regression analysis was performed to identify the clinical, demographic, radiologic, and electrophysiologic variables independently associated with MCIC in the Quality of Life in Epilepsy-31 Inventory (QOLIE-31) overall score 1 year after ATL in 77 consecutive patients with unilateral MTLE-HS...
March 23, 2017: Epilepsia
https://www.readbyqxmd.com/read/28331298/psychosocial-predictors-of-patient-adherence-to-disease-modifying-therapies-for-multiple-sclerosis
#3
Fahad D Alosaimi, Alaa AlMulhem, Hanan AlShalan, Mohammad Alqazlan, Abdulgader Aldaif, Matthew Kowgier, Janooshsheya Balasundaram, Sanjeev Sockalingam
OBJECTIVES: Our aim was to identify the impact of psychosocial predictors, specifically relationship style, depressive symptoms, anxiety symptoms, cognitive impairment, and culture-specific disease beliefs, on treatment adherence for multiple sclerosis (MS) patients. METHODS: In this cross-sectional observational study, patients from two MS clinics in Saudi Arabia completed self-reported questionnaires focused on MS treatment adherence, physical symptom burden, relationship style, cultural beliefs, depressive symptoms, anxiety, and cognitive impairment...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28327056/multiple-sclerosis-and-suicide
#4
Anthony Feinstein, Bennis Pavisian
Mortality rates are elevated in people with multiple sclerosis (MS) relative to the general population. There is, however, some uncertainty whether suicide contributes to this. Epidemiological data suggest that the standardized mortality ratio (SMR) for suicide in MS is approximately twice that of the general population with younger males in the first few years following diagnosis most at risk. Rates of suicidal intent, a potential harbinger of more self-destructive behavior, are also elevated, but the frequency with which intent is followed by suicide is not known...
March 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28315666/feasibility-and-safety-of-a-powered-exoskeleton-for-assisted-walking-for-persons-with-multiple-sclerosis-a-single-group-preliminary-study
#5
Allan J Kozlowski, Michelle Fabian, Dipan Lad, Andrew Delgado
OBJECTIVE: To examine the feasibility, safety, and secondary benefit potential of exoskeleton-assisted walking with one device for persons with multiple sclerosis (MS) DESIGN: Single-group longitudinal preliminary study with 8-week baseline, 8-week intervention, and 4-week follow-up. SETTING: Outpatient MS clinic at tertiary care hospital. PARTICIPANTS: The 13 participants were mostly female who ranged in age from 38-62 years and on Expanded Disability Status Scale scores from 5...
March 15, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28302163/matrix-metalloproteinase-activity-stimulates-n-cadherin-shedding-and-the-soluble-n-cadherin-ectodomain-promotes-classical-microglial-activation
#6
Katherine Conant, Stefano Daniele, P Lorenzo Bozzelli, Tsion Abdi, Amanda Edwards, Arek Szklarczyk, India Olchefske, David Ottenheimer, Kathleen Maguire-Zeiss
BACKGROUND: Matrix metalloproteinases (MMPs) are a family of enzymes that are typically released from intracellular stores to act on specific extracellular substrates. MMP expression and activity can be increased in a neuronal activity-dependent manner, and further increased in response to tissue injury. MMP substrates include cell adhesion molecules (CAMs) that are abundantly expressed in the brain and well positioned for membrane proximal cleavage. Importantly, CAM integrity is important to synaptic structure and axon-myelin interactions, and shed ectodomains may themselves influence cellular function...
March 17, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28298551/high-hypothetical-interest-in-physician-assisted-death-in-multiple-sclerosis
#7
Ruth Ann Marrie, Amber Salter, Tuula Tyry, Gary R Cutter, Stacey Cofield, Robert J Fox
OBJECTIVE: To assess the opinions of persons with multiple sclerosis (MS) regarding physician-assisted death (PAD). METHODS: We surveyed participants in the North American Research Committee on Multiple Sclerosis (NARCOMS) Registry regarding PAD. For each of 5 hypothetical situations, respondents indicated whether they definitely would, probably would, probably would not, or definitely would not consider PAD. They also reported their sociodemographics, disability status using Patient-Determined Disease Steps, depression status, pain status, religiosity, and degree of social support...
March 15, 2017: Neurology
https://www.readbyqxmd.com/read/28293978/piloting-an-email-based-resource-package-for-job-seekers-with-multiple-sclerosis
#8
Diana Dorstyn, Rachel Roberts, Gregory Murphy, Ian Kneebone, Christine Migliorini, Ashley Craig, Claire Hutchinson, Deborah Field
PURPOSE: Media-based rehabilitation provides a powerful opportunity to examine vocational behaviors in the disability sector. However, this research is preliminary at best. This paper reports pilot data. METHOD: Eighteen adults with multiple sclerosis (MS) accessed an email-delivered, resource-based package, Work and MS. Pre- and post-access vocational self-efficacy and identity (Job-Procurement Self Efficacy Scale, My Vocational Situation Scale- primary outcomes), life orientation and depressed mood (Life Orientation Test - revised and Patient Health Questionnaire-9 - secondary outcomes) were assessed...
May 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28283107/sexual-dysfunction-levels-in-iranian-women-suffering-from-multiple-sclerosis
#9
Nahid Dehghan-Nayeri, Zohreh Khakbazan, Faezeh Ghafoori, Seyed Massood Nabavi
OBJECTIVE: Sexual dysfunction (SD) is a common complaint in women who suffer from Multiple Sclerosis (MS), which has been categorized in three levels (primary, secondary, and tertiary) in previous studies. This study was conducted to assess the prevalence of sexual dysfunction (SD) at each level, and to identify associated factors and their impacts on SD in married women who suffer from Multiple Sclerosis. This study was conducted in Iran where the cultural barriers are recognized as important challenges in sexual function...
February 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28273778/the-impact-of-subjective-cognitive-fatigue-and-depression-on-cognitive-function-in-patients-with-multiple-sclerosis
#10
Daniel Golan, Glen M Doniger, Karl Wissemann, Myassar Zarif, Barbara Bumstead, Marijean Buhse, Lori Fafard, Idit Lavi, Jeffrey Wilken, Mark Gudesblatt
BACKGROUND: The association between subjective cognitive fatigue and objective cognitive dysfunction in patients with multiple sclerosis (PwMS) has been studied, with conflicting results. OBJECTIVE: To explore the impact of fatigue on cognitive function, while controlling for the influence of depression, disability, comorbidities, and psychotropic medications. METHODS: PwMS completed a computerized cognitive testing battery with age- and education-adjusted cognitive domain scores...
February 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28273771/revisiting-cognitive-reserve-and-cognition-in-multiple-sclerosis-a-closer-look-at-depression
#11
Viral P Patel, Lisa As Walker, Anthony Feinstein
BACKGROUND: The protective effect of cognitive reserve (CR) on cognition in people with multiple sclerosis (PwMS) has been well described. OBJECTIVE: To explore the relationship between aspects of CR, namely, leisure pursuits and depression. METHODS: In a cross-sectional study, a sample of 155 PwMS and 115 healthy controls (HC) underwent cognitive testing with the Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS) battery...
February 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28273763/the-influence-of-posterior-visual-pathway-damage-on-visual-information-processing-speed-in-multiple-sclerosis
#12
Iñigo Gabilondo, Oiane Rilo, Natalia Ojeda, Javier Pena, Ainara Gómez-Gastiasoro, Mar Mendibe Bilbao, Alfredo Rodríguez-Antigüedad, Alberto Cabrera, Ibai Diez, Naroa Ibarretxe-Bilbao
BACKGROUND: The injury of visual pathway and abnormalities of visual processing speed (VPS) are frequent in MS, but their association remains unexplored. OBJECTIVE: To evaluate the impact of posterior visual pathway structural and functional integrity on VPS of MS patients. METHODS: Cross-sectional study of 30 MS patients and 28 controls, evaluating the association of a VPS tests composite (Salthouse Perceptual Comparison test, Trail Making Test A and Symbol Digit Modalities Test) with 3T MRI visual cortex thickness, optic radiations (OR) diffusion tensor imaging indexes, and medial visual component (MVC) functional connectivity (FC) (MVC-MVC FC (iFC) and MVC-brain FC (eFC)) by linear regression, removing the effect of premorbid IQ, fatigue, and depression...
November 1, 2016: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28267811/patient-education-for-people-with-multiple-sclerosis-associated-fatigue-a-systematic-review
#13
Maria Janina Wendebourg, Christoph Heesen, Marcia Finlayson, Björn Meyer, Jana Pöttgen, Sascha Köpke
BACKGROUND: Multiple Sclerosis (MS) is an inflammatory and neurodegenerative disease often causing decreased quality of life, social withdrawal and unemployment. Studies examining the effect of pharmacological interventions demonstrated only minor effects, whereas non-pharmacological interventions as e.g. patient education programs have shown promising results. OBJECTIVE: We aim to systematically review the literature to determine the effect of patient education programs on fatigue in MS...
2017: PloS One
https://www.readbyqxmd.com/read/28245725/brain-structural-changes-in-patients-in-the-early-stages-of-multiple-sclerosis-with-depression
#14
J I Rojas, F Sanchez, L Patrucco, J Miguez, C Besada, E Cristiano
Some studies suggest an inflammatory mechanism associated with the presence of depression in multiple sclerosis (MS); however, there is little data concerning these findings. The purpose of this study was to investigate the presence of brain structural changes in patients with MS and depression and to compare them with patients suffering from MS without depression and healthy controls. METHODS: A case-control study that included patients with relapsing-remitting MS (RRMS) defined by validated criteria, over 18 years of age, with less than three years from disease onset, EDSS ≤ 3, with no history of previous depression and under immunomodulatory treatment with interferon beta, if any...
March 1, 2017: Neurological Research
https://www.readbyqxmd.com/read/28241935/remotely-engaged-lessons-from-remote-monitoring-in-multiple-sclerosis
#15
Matthew M Engelhard, Stephen D Patek, Kristina Sheridan, John C Lach, Myla D Goldman
OBJECTIVES: Evaluate web-based patient-reported outcome (wbPRO) collection in MS subjects in terms of feasibility, reliability, adherence, and subject-perceived benefits; and quantify the impact of MS-related symptoms on perceived well-being. METHODS: Thirty-one subjects with MS completed wbPROs targeting MS-related symptoms over six months using a customized web portal. Demographics and clinical outcomes were collected in person at baseline and six months. RESULTS: Approximately 87% of subjects completed wbPROs without assistance, and wbPROs strongly correlated with standard PROs (r>0...
April 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/28241776/the-effectiveness-of-robot-assisted-gait-training-versus-conventional-therapy-on-mobility-in-severely-disabled-progressive-multiple-sclerosis-patients-ragtime-study-protocol-for-a-randomized-controlled-trial
#16
Sofia Straudi, Fabio Manfredini, Nicola Lamberti, Paolo Zamboni, Francesco Bernardi, Giovanna Marchetti, Paolo Pinton, Massimo Bonora, Paola Secchiero, Veronica Tisato, Stefano Volpato, Nino Basaglia
BACKGROUND: Gait and mobility impairments affect the quality of life (QoL) of patients with progressive multiple sclerosis (MS). Robot-assisted gait training (RAGT) is an effective rehabilitative treatment but evidence of its superiority compared to other options is lacking. Furthermore, the response to rehabilitation is multidimensional, person-specific and possibly involves functional reorganization processes. The aims of this study are: (1) to test the effectiveness on gait speed, mobility, balance, fatigue and QoL of RAGT compared to conventional therapy (CT) in progressive MS and (2) to explore changes of clinical and circulating biomarkers of neural plasticity...
February 27, 2017: Trials
https://www.readbyqxmd.com/read/28239850/depressive-symptomology-in-multiple-sclerosis-disability-cardiorespiratory-fitness-and-heart-rate-variability
#17
I Ensari, L A Pilutti, R W Motl
OBJECTIVES: This study aimed to investigate whether neurological disability status, heart rate variability (HRV), cardiorespiratory fitness (CRF) explained the variance in depressive symptoms in multiple sclerosis (MS). METHODS: Associations between CRF (via maximal oxygen uptake; VO2peak ), HRV indices of normalized ultra-low (nULF) and very low frequency domains (nVLF), neurological disability status and depressive symptoms (using the Depression subscale of the Hospital Anxiety Depression Scale; HADS-D) were assessed in 53 participants with MS and 17 matched controls...
February 26, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28239781/validation-of-the-promis-%C3%A2-measures-of-self-efficacy-for-managing-chronic-conditions
#18
Ann L Gruber-Baldini, Craig Velozo, Sergio Romero, Lisa M Shulman
PURPOSE: The Patient-Reported Outcomes Measurement Information System(®) (PROMIS(®)) was designed to develop, validate, and standardize item banks to measure key domains of physical, mental, and social health in chronic conditions. This paper reports the calibration and validation testing of the PROMIS Self-Efficacy for Managing Chronic Conditions measures. METHODS: PROMIS Self-Efficacy for Managing Chronic Conditions item banks comprise five domains, Self-Efficacy for Managing: Daily Activities, Symptoms, Medications and Treatments, Emotions, and Social Interactions...
February 26, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28238679/how-does-paying-attention-improve-sexual-functioning-in-women-a%C3%A2-review-of-mechanisms
#19
REVIEW
Nikita Arora, Lori A Brotto
INTRODUCTION: Female sexual dysfunction (FSD), consisting of a constellation of distressing sexual symptoms, is highly prevalent worldwide. Given the central role played by psychological factors in the development of FSD, psychologically and in particular mindfulness-based interventions have arisen as potential treatment options for women. Although mindfulness-based interventions have been evaluated in samples of women with gynecologic cancer; a history of sexual abuse; multiple sclerosis; and spinal cord injury; and provoked vestibulodynia, the mechanisms by which mindfulness leads to improvements in sexual functioning are largely unstudied...
February 23, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28223806/efficacy-of-a-short-cognitive-training-program-in-patients-with-multiple-sclerosis
#20
María Yaiza Pérez-Martín, Montserrat González-Platas, Pablo Eguía-Del Río, Cristina Croissier-Elías, Alejandro Jiménez Sosa
BACKGROUND: Cognitive impairment is a common feature in multiple sclerosis (MS) and may have a substantial impact on quality of life. Evidence about the effectiveness of neuropsychological rehabilitation is still limited, but current data suggest that computer-assisted cognitive training improves cognitive performance. OBJECTIVE: The objective of this study was to evaluate the efficacy of combined computer-assisted training supported by home-based neuropsychological training to improve attention, processing speed, memory and executive functions during 3 consecutive months...
2017: Neuropsychiatric Disease and Treatment
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