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https://www.readbyqxmd.com/read/29036844/multiple-sclerosis-and-sexual-dysfunction-a%C3%A2-need-for-further-education-and%C3%A2-interdisciplinary-care
#1
Kate E Delaney, Jayne Donovan
BACKGROUND: Multiple sclerosis (MS) is an autoimmune condition affecting young women and men, resulting in varied disabilities, including sexual dysfunction. OBJECTIVE: This narrative review aims to describe the prevalence, pathophysiology, and impact of sexual dysfunction in people with MS (PwMS); provide a review of current assessment and treatment strategies; and offer considerations for future care. METHODS: Literature review was performed to identify primary and secondary sources discussing sexual dysfunction in PwMS...
October 8, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/29033642/the-effect-of-type-d-personality-on-quality-of-life-in-patients-with-multiple-sclerosis
#2
Seden Demirci, Kadir Demirci, Serpil Demirci
INTRODUCTION: The Type D personality was reported as an important indicator of adverse clinical outcomes and quality of life in various diseases. The objective of this study was to investigate the relationships between the Type D personality and clinical features and the effect of Type D personality on quality of life in patients with multiple sclerosis (MS). METHODS: Seventy-four patients with MS participated in this study. Clinical parameters of the patients were recorded and disability was assessed using the Expanded Disability Status Scale (EDSS)...
September 2017: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/29020113/a-systematic-review-of-the-effectiveness-of-self-management-interventions-in-people-with-multiple-sclerosis-at-improving-depression-anxiety-and-quality-of-life
#3
Tara Kidd, Nicola Carey, Freda Mold, Sue Westwood, Maria Miklaucich, Emmanouela Konstantara, Annette Sterr, Debbie Cooke
BACKGROUND: Self-management interventions have become increasingly popular in the management of long-term health conditions; however, little is known about their impact on psychological well-being in people with Multiple Sclerosis (MS). PURPOSE: To examine the effectiveness of self-management interventions on improving depression, anxiety and health related quality of life in people with MS. METHOD: A structured literature search was conducted for the years 2000 to 2016...
2017: PloS One
https://www.readbyqxmd.com/read/28989549/the-effectiveness-of-mindfulness-based-stress-reduction-on-psychological-distress-and-cognitive-functioning-in-patients-with-multiple-sclerosis-a-pilot-study
#4
Roos J Blankespoor, Melanie P J Schellekens, Sandra H Vos, Anne E M Speckens, Brigit A de Jong
Patients with multiple sclerosis (MS) often suffer from psychological distress and cognitive dysfunctioning. These factors negatively impact the health-related quality of life. Only recently behavioral therapeutic approaches are being used to treat psychological distress in MS. The aim of the present pilot study was not only to investigate the effectiveness of mindfulness-based stress reduction (MBSR) on psychological distress but also to explore whether it can improve cognitive functioning among patients with MS...
2017: Mindfulness
https://www.readbyqxmd.com/read/28987615/improving-the-quality-of-depression-and-pain-care-in-multiple-sclerosis-using-collaborative-care-the-ms-care-trial-protocol
#5
Dawn M Ehde, Kevin N Alschuler, Mark D Sullivan, Ivan P Molton, Marcia A Ciol, Charles H Bombardier, Mary C Curran, Kevin J Gertz, Annette Wundes, Jesse R Fann
BACKGROUND AND OBJECTIVES: Evidence-based pharmacological and behavioral interventions are often underutilized or inaccessible to persons with multiple sclerosis (MS) who have chronic pain and/or depression. Collaborative care is an evidence-based patient-centered, integrated, system-level approach to improving the quality and outcomes of depression care. We describe the development of and randomized controlled trial testing a novel intervention, MS Care, which uses a collaborative care model to improve the care of depression and chronic pain in a MS specialty care setting...
October 4, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28984619/the-therapeutic-use-of-non-invasive-brain-stimulation-in-multiple-sclerosis-a-review
#6
Rosa Iodice, Fiore Manganelli, Raffaele Dubbioso
BACKGROUND: Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system and a leading cause of disability in young adults. Many disabling symptoms in MS, such as spasticity, pain, depression and cognitive deficits are not fully controlled by drug treatment. Non-invasive brain stimulation (NIBS) techniques can be used as tools for modulating altered cortical excitability and plasticity MS patients, providing an improvement in disabling symptoms affecting such patients...
2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/28979791/cognitive-and-neuropsychiatric-disorders-among-ms-patients-from-latin-america
#7
REVIEW
Sandra Vanotti, Fernando J Caceres
Cognitive and neuropsychiatric disorders in patients with multiple sclerosis have been extensively documented. The focus of this review will be on cognitive and neuropsychiatric disorders in multiple sclerosis patients from Latin America, in the context of international literature. Multicentre studies carried out in Latin America have shown that 43% of the patients have cognitive impairment and 34.5% in early stages of the disease, 29% depression and 20.9% neuropsychiatric disorders. The profile of cognitive impairment corresponds to alterations in visual and verbal memory, in attention, in information processing speed and in verbal fluency...
July 2017: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/28955298/subjective-cognitive-fatigue-and-autonomic-abnormalities-in-multiple-sclerosis-patients
#8
Carina Sander, Helmut Hildebrandt, Hans-Peter Schlake, Paul Eling, Katrin Hanken
BACKGROUND: Cognitive fatigue and autonomic abnormalities are frequent symptoms in MS. Our model of MS-related fatigue assumes a shared neural network for cognitive fatigue and autonomic failures, i.e., aberrant vagus nerve activity induced by inflammatory processes. Therefore, they should occur in common. OBJECTIVE: To explore the relationship between cognitive fatigue and autonomic symptoms in MS patients, using self-reported questionnaires. METHODS: In 95 MS patients, cognitive fatigue was assessed with the Fatigue Scale for Motor and Cognitive Functions and autonomic abnormalities with the Composite Autonomic Symptom Scale-31 (COMPASS-31)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28953809/depression-sleep-disturbances-and-anxiety-in-patients-with-relapsing-remitting-multiple-sclerosis-a-longitudinal-cohort-observation
#9
Paulina Brozek, Marta Brachmanska, Katarzyna Rabiczko, Weronika Bulska, Marta Ciulkowicz, Ewa Krzystanek
BACKGROUND: Depression, sleep disturbances and anxiety may affect almost half of the population of patients with multiple sclerosis (MS) and they are major determinants of poor quality of life in young adults. The aim of our study was to assess their incidence in patients with MS in Poland, and whether they change during longitudinal observation in routine clinical practice. SUBJECTS AND METHODS: We included 53 consecutive patients with relapsing-remitting form of MS in this prospective study, who were treated in our department...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28934996/balancing-the-demands-of-two-tasks-an-investigation-of-cognitive-motor-dual-tasking-in-relapsing-remitting-multiple-sclerosis
#10
Emma Butchard-MacDonald, Lorna Paul, Jonathan J Evans
BACKGROUND: People with relapsing remitting multiple sclerosis (PwRRMS) suffer disproportionate decrements in gait under dual-task conditions, when walking and a cognitive task are combined. There has been much less investigation of the impact of cognitive demands on balance. OBJECTIVES: This study investigated whether: (1) PwRRMS show disproportionate decrements in postural stability under dual-task conditions compared to healthy controls, and (2) dual-task decrements are associated with everyday dual-tasking difficulties...
September 22, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28934025/tamec-a-new-analogue-of-cyclomyrsinol-diterpenes-decreases-anxiety-and-depression-like-behaviors-in-a-mouse-model-of-multiple-sclerosis
#11
Abdul Majid Ayatollahi, Mostafa Haji Molla Hoseini, Syed Mustafa Ghanadian, Morteza Kosari-Nasab, Fatemeh Mami, Zeinab Yazdiniapoure, Behzad Zolfaghari, Ali-Akbar Salari
Objectives There is a significant prevalence of affective disorders including depression and anxiety in people with multiple sclerosis (MS), resulting in reduced quality of life. Since the current treatments are not generally effective, further studies are needed to find appropriate drugs to alleviate anxiety and depression symptoms in these patients. Methods The effects of a new analog of cyclomyrsinol diterpenes (TAMEC) isolated from Euphorbia sogdiana on the anxiety (open field and elevated plus maze test) and depressive-like behaviors (sucrose preference test and forced swim test) in EAE-induced C57BL/6 mice (EAE; a mouse model of MS) were investigated...
September 21, 2017: Neurological Research
https://www.readbyqxmd.com/read/28933614/coping-strategies-and-adjustment-to-multiple-sclerosis-among-recently-diagnosed-patients-the-mediating-role-of-sense-of-coherence
#12
Emanuela Calandri, Federica Graziano, Martina Borghi, Silvia Bonino
OBJECTIVE: To examine the relationship between coping strategies (problem solving, emotional release, and avoidance) and adjustment (health-related quality of life, depression, and affective well-being) in a group of recently diagnosed multiple sclerosis patients (up to three years since diagnosis), and to explore the mediating role of sense of coherence between coping strategies and adjustment. DESIGN: Cross-sectional. SETTING: Multiple Sclerosis Clinic Centre...
October 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28928713/pain-in-people-with-multiple-sclerosis-associations-with-modifiable-lifestyle-factors-fatigue-depression-anxiety-and-mental-health-quality-of-life
#13
Claudia H Marck, Alysha M De Livera, Tracey J Weiland, Pia L Jelinek, Sandra L Neate, Chelsea R Brown, Keryn L Taylor, Fary Khan, George A Jelinek
BACKGROUND: People with multiple sclerosis (MS) often experience pain, which can interfere with mobility, employment, and quality of life (QOL). METHODS: This cross-sectional study explored associations between pain, demographic, disease, and modifiable lifestyle factors in an international sample of people with MS recruited online. RESULTS: Substantial pain, of moderate/severe intensity and interfering at least moderately with work/household or enjoyment of life in the past 4 weeks, was reported by 682/2,362 (28...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28915856/exercise-prescription-for-patients-with-multiple-sclerosis-potential-benefits-and-practical-recommendations
#14
Farzin Halabchi, Zahra Alizadeh, Mohammad Ali Sahraian, Maryam Abolhasani
BACKGROUND: Multiple sclerosis (MS) can result in significant mental and physical symptoms, specially muscle weakness, abnormal walking mechanics, balance problems, spasticity, fatigue, cognitive impairment and depression. Patients with MS frequently decrease physical activity due to the fear from worsening the symptoms and this can result in reconditioning. Physicians now believe that regular exercise training is a potential solution for limiting the reconditioning process and achieving an optimal level of patient activities, functions and many physical and mental symptoms without any concern about triggering the onset or exacerbation of disease symptoms or relapse...
September 16, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28913617/fingolimod-induces-neuronal-specific-gene-expression-with-potential-neuroprotective-outcomes-in-maturing-neuronal-progenitor-cells-exposed-to-hiv
#15
Rebeca Geffin, Ricardo Martinez, Alicia de Las Pozas, Biju Issac, Micheline McCarthy
Fingolimod (FTY720), a structural analogue of sphingosine, targets sphingosine-1-phosphate receptor signaling and is currently an immunomodulatory therapy for multiple sclerosis. Fingolimod accesses the central nervous system (CNS) where its active metabolite, fingolimod phosphate (FTY720-P), has pleotropic neuroprotective effects in an inflammatory microenvironment. To investigate potential neuronal-specific mechanisms of fingolimod neuroprotection, we cultured the human neuronal progenitor cell line, hNP1, in differentiation medium supplemented with HIV- or Mock-infected supernatants, with or without FTY720-P...
September 14, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/28904538/the-effect-of-group-cognitive-behavioral-therapy-on-stress-anxiety-and-depression-of-women-with-multiple-sclerosis
#16
Saeid Pahlavanzadeh, Samira Abbasi, Nasrollah Alimohammadi
BACKGROUND: One of the factors that could influence the quality of life in patients with multiple sclerosis, which is usually overlooked, is its psychological aspects. Considering the increasing acceptance of complementary medicine in the health system, this study was designed and conducted to determine the effect of group cognitive therapy on the stress, anxiety, and depression of women suffering from multiple sclerosis. MATERIALS AND METHODS: This clinical trial was conducted among 70 women suffering from multiple sclerosis who were referred to the health centers of Isfahan...
July 2017: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/28901547/cognitive-functioning-following-one-year-natalizumab-treatment-a-non-randomized-clinical-trial
#17
I Rorsman, C Petersen, P C Nilsson
OBJECTIVES: Cognitive impairment is common in multiple sclerosis (MS) and can have serious impact on social and occupational functioning. Natalizumab reduces relapse rates, magnetic resonance imaging (MRI) lesions, and progression of disability. Previous studies on cognitive functioning have not based inclusion on cognitive performance criteria. The aim of the present study was to determine any potential natalizumab-related cognitive effects on MS patients performing below normal limits on neuropsychological testing...
September 13, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28898535/characterization-of-social-cognition-impairment-in-multiple-sclerosis
#18
Mireille Neuhaus, Sara Bagutti, Özgür Yaldizli, Dominik Zwahlen, Simeon Schaub, Bettina Frey, Bettina Fischer-Barnicol, Jean-Marc Burgunder, Marie-Dominique Martory, Jana Pöttgen, Jean-Marie Annoni, Iris-Katharina Penner
BACKGROUND: Multiple sclerosis (MS) has been associated with deficits in social cognition. However, little is known about which domains of social cognition are predominantly affected and what other factors are associated with it. OBJECTIVES: 1) To characterize social cognition deficit in a group of MS outpatients. 2) To relate impairment in social cognition to overall cognitive status, depression and fatigue. METHODS: Thirty-five MS patients (mean disease duration 12...
September 12, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28894435/neuroactive-steroids-receptor-interactions-and-responses
#19
REVIEW
Kald Beshir Tuem, Tesfay Mehari Atey
Neuroactive steroids (NASs) are naturally occurring steroids, which are synthesized centrally as de novo from cholesterol and are classified as pregnane, androstane, and sulfated neurosteroids (NSs). NASs modulate many processes via interacting with gamma-aminobutyric acid (GABA), N-methyl-d-aspartate, serotonin, voltage-gated calcium channels, voltage-dependent anion channels, α-adrenoreceptors, X-receptors of the liver, transient receptor potential channels, microtubule-associated protein 2, neurotrophin nerve growth factor, and σ1 receptors...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28894432/behavioral-changes-in-patients-with-multiple-sclerosis
#20
Mirjam R Heldner, Sigal Kaufmann-Ezra, Klemens Gutbrod, Corrado Bernasconi, Sandra Bigi, Verena Blatter, Heinrich P Mattle, René M Müri, Rajeev K Verma, Christian P Kamm
BACKGROUND: Behavioral changes are common in patients with multiple sclerosis (MS), however not as readily recognized as cognitive impairments. OBJECTIVE: The aim of this study was to analyze behavioral changes and its relation to disease characteristics, disability, and cognitive impairments in patients with MS. METHOD: This is a single-center cross-sectional study. A detailed neuropsychological examination, including the Frontal Systems Behavior Scale (FrSBe), the Beck depression inventory (BDI), and the Wuerzburg Fatigue Inventory for Multiple Sclerosis (WEIMuS) test, was performed...
2017: Frontiers in Neurology
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