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https://www.readbyqxmd.com/read/28647714/the-burden-of-multiple-sclerosis-and-patients-coping-strategies
#1
Lorena Lorefice, Giuseppe Fenu, Jessica Frau, Giancarlo Coghe, Maria Giovanna Marrosu, Eleonora Cocco
OBJECTIVES: Multiple sclerosis (MS) is a chronic disease that mainly affects young people. Patients with MS experience several emotional responses to changed perceptions of themselves and manage this situation in ways focused on controlling the overall burden of disease. This present study aimed to evaluate differences between patients with MS and healthy controls (HCs) in coping styles, identifying the MS clinical features that influence adaptive responses. METHODS: Patients with MS, according to the McDonald 2010 criteria, and HCs were recruited...
June 24, 2017: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/28646860/effect-of-exercising-at-minimum-recommendations-of-the-multiple-sclerosis-exercise-guideline-combined-with-structured-education-or-attention-control-education-secondary-results-of-the-step-it-up-randomised-controlled-trial
#2
Susan Coote, Marcin Uszynski, Matthew P Herring, Sara Hayes, Carl Scarrott, John Newell, Stephen Gallagher, Aidan Larkin, Robert W Motl
BACKGROUND: Recent exercise guidelines for people with multiple sclerosis (MS) recommend a minimum of 30 min moderate intensity aerobic exercise and resistance exercise twice per week. This trial compared the secondary outcomes of a combined 10-week guideline based intervention and a Social Cognitive Theory (SCT) education programme with the same exercise intervention involving an attention control education. METHODS: Physically inactive people with MS, scoring 0-3 on Patient Determined Disease Steps Scale, with no MS relapse or change in MS medication, were randomised to 10-week exercise plus SCT education or exercise plus attention control education conditions...
June 24, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28645572/longitudinal-associations-between-mental-health-conditions-and-overactive-bladder-in-women-veterans
#3
Catherine S Bradley, Ingrid E Nygaard, Stephen L Hillis, James C Torner, Anne G Sadler
BACKGROUND: One in five recently deployed U.S. women veterans report overactive bladder symptoms. Mental health conditions such as depression and anxiety commonly co-occur in women with overactive bladder, but temporal relationships between these outcomes have not been well-studied, and the mechanism behind this association is unknown. The Women Veterans Urinary Health Study, a nationwide longitudinal study in recently deployed women veterans, was designed to better understand relationships between overactive bladder and mental health conditions...
June 20, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28638707/sexual-dysfunction-in-female-patients-with-relapsing-remitting-multiple-sclerosis
#4
Pawel Bartnik, Aleksandra Wielgoś, Joanna Kacperczyk, Katarzyna Pisarz, Iwona Szymusik, Aleksandra Podlecka-Piętowska, Beata Zakrzewska-Pniewska, Miroslaw Wielgoś
INTRODUCTION: Sexual dysfunction (SD) is one of the common symptoms of multiple sclerosis (MS) and is often underdiagnosed, especially in women. Relapsing-remitting multiple sclerosis (RRMS) is the most widespread form of the disease, but the data on SD occurrence in this particular group of patients is limited. The aim of the study was to analyze the associations between demographic factors, symptoms and signs of MS, psychiatric comorbidities and SD in female patients with RRMS. MATERIAL & METHODS: A subgroup of 86 sexually active women with RRMS out of 218 total MS respondents was analyzed...
June 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28629784/-from-paediatric-urological-care-to-adult-urology-assessment-of-a-transition-consultation-for-adolescents
#5
L Even, S Mouttalib, J Moscovici, M Soulie, P Rischmann, X Game, P Galinier, O Bouali
To provide an adequate lifelong urological care in the complex period of adolescence, a transition consultation conducted by a paediatric surgeon and an urologist was developed in our institution. As a real rite of passage, it allows the follow-up and the adapted care of urological conditions, sometimes complex, and permits the transition between childhood and the world of grown-ups. We reported our experience at the Children Hospital of our institution (paediatric surgery and urology departments). During a 6 months period (January-July 2015), forty-five young adults with a mean age of 17...
June 16, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/28620343/international-differences-in-multiple-sclerosis-health-outcomes-and-associated-factors-in-a-cross-sectional-survey
#6
Grace D Reilly, Awng Shar Mahkawnghta, Pia L Jelinek, Alysha M De Livera, Tracey J Weiland, Chelsea R Brown, Keryn L Taylor, Sandra L Neate, George A Jelinek, Claudia H Marck
Multiple sclerosis (MS) is a major cause of disability and poor quality of life (QOL). Previous studies have shown differences in MS health outcomes between countries. This study aimed to examine the associations between international regions and health outcomes in people with MS. Self-reported data were taken from the Health Outcomes and Lifestyle In a Sample of people with Multiple Sclerosis online survey collected in 2012. The 2,401 participants from 37 countries were categorized into three regions: Australasia, Europe, and North America...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28607753/a-group-delivered-self-management-program-reduces-spasticity-in-people-with-multiple-sclerosis-a-randomized-controlled-pilot-trial
#7
Cinda L Hugos, Dennis Bourdette, Yiyi Chen, Zunqiu Chen, Michelle Cameron
BACKGROUND: Spasticity affects more than 80% of people with multiple sclerosis (MS), affecting activity, participation, and quality of life. Based on an international guideline, an MS spasticity group education and stretching program, MS Spasticity: Take Control (STC), has been developed. OBJECTIVE: The objective of this paper is to determine whether STC with home stretching is associated with greater changes in spasticity than usual care (UC), consisting of an illustrated stretching booklet and home stretching but without group instruction or support, in people with MS...
January 2017: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/28602542/moderators-of-exercise-effects-on-depressive-symptoms-in-multiple-sclerosis-a-meta-regression
#8
REVIEW
Matthew P Herring, Karl M Fleming, Sara P Hayes, Robert W Motl, Susan B Coote
CONTEXT: This study examined the extent to which patient and trial characteristics moderate the effects of exercise on depressive symptoms among people with multiple sclerosis. EVIDENCE ACQUISITION: Twenty-four effects were derived from 14 articles published before August 2016 located using Google Scholar, MEDLINE, PsycINFO, PubMed, and Web of Science. Trials involved 624 people with multiple sclerosis and included both randomization to exercise training or a non-exercise control condition and measurement of depressive symptoms at baseline and at mid- and/or post-intervention...
June 8, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28600189/effect-of-high-dose-simvastatin-on-cognitive-neuropsychiatric-and-health-related-quality-of-life-measures-in-secondary-progressive-multiple-sclerosis-secondary-analyses-from-the-ms-stat-randomised-placebo-controlled-trial
#9
Dennis Chan, Sophie Binks, Jennifer M Nicholas, Chris Frost, M Jorge Cardoso, Sebastien Ourselin, David Wilkie, Richard Nicholas, Jeremy Chataway
BACKGROUND: In the 24-month MS-STAT phase 2 trial, we showed that high-dose simvastatin significantly reduced the annualised rate of whole brain atrophy in patients with secondary progressive multiple sclerosis (SPMS). We now describe the results of the MS-STAT cognitive substudy, in which we investigated the treatment effect on cognitive, neuropsychiatric, and health-related quality-of-life (HRQoL) outcome measures. METHODS: We did a secondary analysis of MS-STAT, a 24-month, double-blind, controlled trial of patients with SPMS done at three neuroscience centres in the UK between Jan 28, 2008, and Nov 4, 2011...
June 6, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28597907/mindfulness-based-cognitive-therapy-severely-fatigued-multiple-sclerosis-patients-a-waiting-list-controlled-study
#10
Alexandra E W Hoogerwerf, Yvonne Bol, Jill Lobbestael, Raymond Hupperts, Caroline M van Heugten
BACKGROUND: Fatigue is the most common symptom in multiple sclerosis. Evidence-based treatment options are scarce. OBJECTIVE: To study the feasibility and potential effectiveness of mindfulness-based cognitive therapy in severely fatigued multiple sclerosis patients. METHODS: Non-randomized pilot study with a wai-ting list control period including 59 multiple sclerosis patients with severe fatigue. PRIMARY OUTCOME MEASURE: fatigue severity subscale of the Checklist Individual Strength-20...
June 8, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28584406/the-relationship-between-psychosocial-factors-and-cognition-in-multiple-sclerosis
#11
Fahad D Alosaimi, Alaa AlMulhem, Mario Moscovici, Hanan AlShalan, Mohammad Alqazlan, Abdulgader Aldaif, Sanjeev Sockalingam
INTRODUCTION: Multiple sclerosis (MS) is a common disorder in some regions of the world, with over 2.3 million people diagnosed worldwide. Cognitive impairment is one of the earliest symptoms to present in the course of the disease and can cause significant morbidity. We proposed a study to explore the psychosocial predictors of cognitive impairment in MS patients in Saudi Arabia, a previously unexplored patient population. METHODS: Demographic data, depression scale (PHQ9), symptom burden (PHQ15), anxiety (GAD7), disease duration, and Montreal Cognitive Assessment (MOCA) scores were collected from 195 patients in a neurology clinic in Ryiadh, Saudi Arabia...
2017: Behavioural Neurology
https://www.readbyqxmd.com/read/28580876/multiple-sclerosis
#12
Dena Sadeghi Bahmani, Pasquale Calabrese, Helene Merkt, Yvonne Naegelin, Markus Gerber, Uwe Pühse, Edith Holsboer-Trachsler, Serge Brand
This study investigated the interrelatedness of physical disability, physical activity, and depression among patients with multiple sclerosis (MS). We hypothesized that self-reported physical activity would mediate the effect of disability on depressive symptoms. Twenty-seven patients with MS (mean age: 49 years; 44.5% females) completed self-rating scales covering sociodemographic variables, intake of antidepressants, physical activity, and symptoms of depression; disability was measured by the Expanded Disability Status Scale...
January 1, 2017: Perceptual and Motor Skills
https://www.readbyqxmd.com/read/28580582/modulating-inflammation-and-neuroprotection-in-multiple-sclerosis
#13
REVIEW
Heather Yong, Gabrielle Chartier, Jacqueline Quandt
Multiple sclerosis (MS) is a neurological disorder of the central nervous system with a presentation and disease course that is largely unpredictable. MS can cause loss of balance, impaired vision or speech, weakness and paralysis, fatigue, depression, and cognitive impairment. Immunomodulation is a major target given the appearance of focal demyelinating lesions in myelin-rich white matter, yet progression and an increasing appreciation for gray matter involvement, even during the earliest phases of the disease, highlights the need to afford neuroprotection and limit neurodegenerative processes that correlate with disability...
June 5, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28566173/vitamin-d3-supplementation-in-multiple-sclerosis-symptoms-and-biomarkers-of-depression
#14
Linda Rolf, Anne-Hilde Muris, Yvonne Bol, Jan Damoiseaux, Joost Smolders, Raymond Hupperts
Depressive symptoms are common in multiple sclerosis (MS), and both depression and MS have been associated with a poor vitamin D status. As cytokine-mediated inflammatory processes play a role in the pathogenesis of both disorders, we hypothesized that vitamin D3 supplementation reduces depressive symptoms in MS via its immunomodulatory properties. In this randomized pilot study relapsing remitting (RR) MS patients received either vitamin D3 supplementation (n=20; 14.000IU/day) or placebo (n=20) during 48weeks...
July 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28555454/-cognitive-training-combined-with-aerobic-exercises-in-multiple-sclerosis-patients-a-pilot-study
#15
R M Jimenez-Morales, L F Herrera-Jimenez, Y Macias-Delgado, Y T Perez-Medinilla, S M Diaz-Diaz, C Forn
INTRODUCTION: The scientific evidences associated to the effectiveness of different techniques of cognitive rehabilitation are still contradictory. AIM: To compare a program of combined training (physical and cognitive) in front of a program of physical training and to observe their effectiveness about the optimization of the cognitive functions in patients with multiple sclerosis (MS). PATIENTS AND METHODS: It was carried out an experimental study in 32 patients with MS...
June 1, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28553882/functional-brain-connectivity-of-remembered-fatigue-or-happiness-in-healthy-adults-use-of-arterial-spin-labeling
#16
Jeff Boissoneault, Landrew Sevel, Michael E Robinson, Roland Staud
INTRODUCTION: Chronic fatiguing illnesses like cancer, multiple sclerosis, chronic fatigue syndrome, or depression are frequently associated with comorbidities including depression, pain, and insomnia, making the study of their neural correlates challenging. To study fatigue without such comorbidities, functional connectivity (FC) analyses were used in healthy individuals to study brain activity during recall of a fatiguing event inside the MRI scanner. A positive mood induction served as control condition...
May 29, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28548605/changes-to-the-septo-fornical-area-might-play-a-role-in-the-pathogenesis-of-anxiety-in-multiple-sclerosis
#17
Miklos Palotai, Andrea Mike, Michele Cavallari, Erzsebet Strammer, Gergely Orsi, Brian C Healy, Katharina Schregel, Zsolt Illes, Charles Rg Guttmann
BACKGROUND: Reports on the relationships between white matter lesion load (WMLL) and fatigue and anxiety in multiple sclerosis (MS) are inconsistent. OBJECTIVE: To investigate the association of total and tract-specific WMLL with fatigue and anxiety. METHODS: Total and regional T2 WMLL was assessed for 19 tracts in 48 MS patients (30 females). ICBM-DTI-81 Atlas-based parcellation was combined with WMLL segmentation of T2-weighted magnetic resonance imaging (MRI)...
May 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28546976/a-comparison-the-effects-of-reflexology-and-relaxation-on-the-psychological-symptoms-in-women-with-multiple-sclerosis
#18
Mozhgan Soheili, Fatemeh Nazari, Vahid Shaygannejad, Mahboobeh Valiani
BACKGROUND: Multiple sclerosis (MS) occurs with a variety of physical and psychological symptoms, yet there is not a conclusive cure for this disease. Complementary medicine is a current treatment which seems is effective in relieving symptoms of patients with MS. Therefore, this study is aimed to determine and compare the effects of reflexology and relaxation on anxiety, stress, and depression in women with MS. SUBJECTS AND METHODS: This study is a randomized clinical trial that is done on 75 women with MS referred to MS Clinic of Kashani Hospital...
2017: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/28544407/no-relevant-impact-of-ambient-temperature-on-disability-measurements-in-a-large-cohort-of-patients-with-multiple-sclerosis
#19
J-P Stellmann, K L Young, E Vettorazzi, J Pöttgen, C Heesen
BACKGROUND AND PURPOSE: Many patients with multiple sclerosis (MS) report a worsening of symptoms due to high ambient temperatures, but objective data about this association are rare and contradictory. The aim of this study was to investigate the influence of ambient temperature on standard clinical tests. METHODS: We extracted the Symbol Digit Modality Test, Nine Hole Peg Test, Timed 25 Foot Walk (T25FW), Timed Tandem Walk, Expanded Disability Status Scale (EDSS) and quality-of-life items on cognition, fatigue and depression from our clinical database and matched them to historical temperatures...
June 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28540774/a-qualitative-study-of-cognitive-behavioural-therapy-in-multiple-sclerosis-experiences-of-psychotherapists
#20
Charlotte Ytterberg, Charlotte Chruzander, Gunnel Backenroth, Marie Kierkegaard, Gerd Ahlström, Kristina Gottberg
PURPOSE: To investigate how psychotherapists experience using individual, face-to-face cognitive behavioural therapy (CBT) aimed at alleviating depressive symptoms in persons with multiple sclerosis (MS). METHOD: Semi-structured interviews with three psychotherapists were conducted after CBT with 12 participants with MS, and analysed using qualitative content analysis. RESULTS: Two main themes emerged: Trusting their expertise as psychotherapists whilst lacking MS-specific knowledge, and The process of exploring the participants' readiness for CBT with modifications of content and delivery...
December 2017: International Journal of Qualitative Studies on Health and Well-being
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