keyword
https://read.qxmd.com/read/38355497/creation-of-a-rating-scale-to-teach-less-invasive-surfactant-administration-lisa-in-simulation
#21
JOURNAL ARTICLE
Hélène Rostoker, Bernard Guillois, Amaya Caradec, François Lecomte, Denis Oriot, Clément Chollat
BACKGROUND: Simulation-based training is gaining increasing prominence in neonatology training. The Less Invasive Surfactant Administration (LISA) method is starting to be taught in simulation. The aim of this educational study was to develop and validate a rating scale for teaching the LISA method in simulation. METHODS: The Downing framework was used to create this performance-rating scale. A first version of the scale was submitted to 12 French and Belgian experts to obtain their opinions...
February 14, 2024: BMC Medical Education
https://read.qxmd.com/read/38349123/disruption-of-the-sp-a-sp-r210-l-myo18a%C3%AE-pathway-prolongs-gestation-and-reduces-fetal-survival-during-lipopolysaccharide-induced-parturition-in-late-gestation
#22
JOURNAL ARTICLE
Zhiwei Guan, Brandon Worth, Todd M Umstead, Shaili Amatya, Jennifer Booth, Zissis C Chroneos
Prolonged labor can lead to infection, fetal distress, asphyxia, and life-threatening harm to both the mother and baby. Surfactant Protein A (SP-A) was shown to contribute to maintenance of pregnancy and timing of term labor. SP-A modulates the stoichiometric expression of the SP-R210L and SP-R210S isoforms of the SP-R210 receptor on alveolar macrophages (AMs). Lack of SP-R210L dysregulates macrophage inflammatory responses. We asked whether SP-A alters normal and inflammation-induced parturition through SP-R210 using SP-A- and SP-R210L -deficient mice...
February 13, 2024: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://read.qxmd.com/read/38346693/substantiating-and-adopting-lung-ultrasound-scores-to-predict-surfactant-need-in-preterm-neonates-with-respiratory-distress-syndrome-within-an-institution
#23
JOURNAL ARTICLE
Belinda Chan, Christopher Torsitano, Sasha Gordon, Olive Konana, Yogen Singh
OBJECTIVE:  Administering surfactant timely and appropriately is important to minimize lung injury but remains challenging in preterm neonates with respiratory distress syndrome. The published literature supports that lung ultrasound (LUS) score can predict surfactant need. Neonatal LUS scanning specification and parameter setting guidelines have been recently published for standardization. However, variations in scanning protocols and machine settings hinder its clinical implementation widely...
February 12, 2024: American Journal of Perinatology
https://read.qxmd.com/read/38341166/survival-without-severe-neonatal-morbidity-after-antenatal-betamethasone-dose-reduction-a-post-hoc-analysis-of-a-randomized-non-inferiority-trial
#24
JOURNAL ARTICLE
Olivier Baud, Loic Sentilhes, Moreno Ursino, Muriel Doret-Dion, Corinne Alberti, Camille Aupiais, Thomas Schmitz
BACKGROUND: Antenatal betamethasone is recommended before preterm delivery to accelerate fetal lung maturation. However, its optimal dose remains unknown. A 50% dose reduction was proposed to decrease the potential dose-related long-term neurodevelopmental side effects, including psychological development, sleep, and emotional disorders. Because non-inferiority of the half-dose on the need for exogenous surfactant was not shown in the primary analysis, its impact on survival without major neonatal morbidity needs to be investigated...
February 8, 2024: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38340014/antenatal-steroids-and-neonatal-outcomes-in-late-preterm-births-with-pregestational-diabetes
#25
JOURNAL ARTICLE
Kavisha Khanuja, Jenani Jayakumaran, Huda B Al-Kouatly, Rodney A McLaren
OBJECTIVE: To evaluate if antenatal steroid use was associated with a lower rate of respiratory complications in neonates born late preterm to patients with pregestational diabetes mellitus (PGDM). METHODS: This was a retrospective cohort study of live, singleton, non-anomalous, late preterm births complicated by PGDM using data from the Centers for Disease Control and National Vital Statistics System from 2017 to 2021. The primary (assisted ventilation use >6 h) and secondary neonatal outcomes (immediate assisted ventilation, Apgar score, neonatal intensive care unit [NICU] admission, and surfactant use) were compared between births that received steroids and those that did not...
February 10, 2024: International Journal of Gynaecology and Obstetrics
https://read.qxmd.com/read/38335761/antenatal-corticosteroid-administration-is-associated-with-lower-risk-of-severe-rop-in-preterm-twin-infants
#26
JOURNAL ARTICLE
Omer Ertekin, Buse Ozer Bekmez, Mehmet Buyuktiryaki, Mustafa Senol Akin, Evrim Alyamac Dizdar, Fatma Nur Sari
INTRODUCTION: Robust evidence revealed the impact of antenatal corticosteroid (ACS) administration on lower mortality and short-term neonatal outcomes in singleton preterm infants. We aimed to investigate the impact of ACS therapy on morbidity and mortality in preterm twin infants. METHODS: We conducted this retrospective single-center study from to the records of twin babies of 24-30 weeks of gestation admitted to the neonatal intensive care unit. The study population was grouped based on the exposure to ACS 1-7 days before birth as received or not...
January 30, 2024: Early Human Development
https://read.qxmd.com/read/38325940/early-pulmonary-hypertension-in-preterm-infants
#27
REVIEW
Srinivasan Mani, Hussnain Mirza, James Ziegler, Praveen Chandrasekharan
Pulmonary hypertension (PH) in preterm neonates has multifactorial pathogenesis with unique characteristics. Premature surfactant-deficient lungs are injured following exposure to positive pressure ventilation and high oxygen concentrations resulting in variable phenotypes of PH. The prevalence of early PH is variable and reported to be between 8% and 55% of extremely preterm infants. Disruption of the lung development and vascular signaling pathway could lead to abnormal pulmonary vascular transition. The management of early PH and the off-label use of selective pulmonary vasodilators continue to be controversial...
March 2024: Clinics in Perinatology
https://read.qxmd.com/read/38320509/coffee-to-make-lisa-a-go
#28
EDITORIAL
Kathrin Hanke, Christoph Härtel
In August of 1963, Patrick Bouvier Kennedy, the fourth child of Jackie Onassis Kennedy and John F. Kennedy, died less than 48 hours after his birth from respiratory distress syndrome (RDS) of the newborn. His tragic death inspired research into the physiology of RDS, one product of which was the development of surfactant replacement therapies which have saved millions of neonates from a similar fate. Shortly after the demonstration of its efficacy in 1980, exogenous surfactant replacement therapy became the mainstay intervention for RDS...
December 2023: NEJM Evid
https://read.qxmd.com/read/38315204/neonatal-point-of-care-lung-ultrasound-what-should-be-known-and-done-out-of-the-nicu
#29
REVIEW
Almudena Alonso-Ojembarrena, Rebeca Gregorio-Hernández, Francesco Raimondi
UNLABELLED: Lung ultrasound is rapidly becoming a useful tool in the care of neonates: its ease of use, reproducibility, low cost, and negligible side effects make it a very suitable tool for the respiratory care of all neonates. This technique has been extensively studied by different approaches in neonatal intensive care unit (NICU), both for diagnostic and prognostic aims and to guide respiratory treatments. However, many neonates are being born in level I/II hospitals without NICU facilities so all pediatricians, not just neonatal intensivists, should be aware of its potential...
February 5, 2024: European Journal of Pediatrics
https://read.qxmd.com/read/38270182/laryngeal-mask-airway-surfactant-administration-for-prevention-of-morbidity-and-mortality-in-preterm-infants-with-or-at-risk-of-respiratory-distress-syndrome
#30
REVIEW
Mohamed E Abdel-Latif, Elizabeth Walker, David A Osborn
BACKGROUND: Laryngeal mask airway surfactant administration (S-LMA) has the potential benefit of surfactant administration whilst avoiding endotracheal intubation and ventilation, ventilator-induced lung injury and bronchopulmonary dysplasia (BPD). OBJECTIVES: To evaluate the benefits and harms of S-LMA either as prophylaxis or treatment (rescue) compared to placebo, no treatment, or intratracheal surfactant administration via an endotracheal tube (ETT) with the intent to rapidly extubate (InSurE) or extubate at standard criteria (S-ETT) or via other less-invasive surfactant administration (LISA) methods on morbidity and mortality in preterm infants with or at risk of respiratory distress syndrome (RDS)...
January 25, 2024: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/38264812/-establishment-and-efficiency-test-of-a-clinical-prediction-model-of-bronchopulmonary-dysplasia-associated-pulmonary-hypertension-in-very-premature-infants
#31
JOURNAL ARTICLE
J K Cao, H Q Fan, Y B Xiao, D Wang, C G Liu, X M Peng, X R Gao, S H Tang, T Han, Y B Mei, H Y Liang, S M Wang, F Wang, Q P Li
Objective: To develop a risk prediction model for identifying bronchopulmonary dysplasia (BPD) associated pulmonary hypertension (PH) in very premature infants. Methods: This was a retrospective cohort study. The clinical data of 626 very premature infants whose gestational age <32 weeks and who suffered from BPD were collected from October 1st , 2015 to December 31st , 2021 of the Seventh Medical Center of the People's Liberation Army General Hospital as a modeling set. The clinical data of 229 very premature infants with BPD of Hunan Children's Hospital from January 1 st , 2020 to December 31st , 2021 were collected as a validation set for external verification...
January 24, 2024: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://read.qxmd.com/read/38261886/predictors-of-cpap-failure-with-ram-cannula-interface-for-primary-respiratory-support-in-preterm-neonates
#32
JOURNAL ARTICLE
Pradeep Kumar, Anita Yadav, Pratima Anand, Pradeep Debata
BACKGROUND: RAM cannula is used as interface for delivering nasal continuous positive airway pressure (nCPAP) in many neonatal care units though the bench to bedside evidence for its use in clinical settings in lacking. METHODS: In this prospective cohort study from tertiary care neonatal care unit, the primary objective was to determine the rate of CPAP failure using RAM interface, within 72 h of starting of therapy and secondary objective was to look for the incidence and severity of nasal trauma with the use of RAM interface for CPAP delivery...
2024: Medical Journal, Armed Forces India
https://read.qxmd.com/read/38249238/a-systematic-review-is-early-fluid-restriction-in-preterm-neonates-going-to-prevent-bronchopulmonary-dysplasia
#33
REVIEW
Suresh Kumar Yadav Bollaboina, Ashok Kumar Urakurva, Saritha Kamsetti, Rakesh Kotha
Preterm birth causes constant challenges, with bronchopulmonary dysplasia (BPD) being a major concern. Immediately after birth, it takes time to establish feeding between the mother and the premature baby. During this time, the telological shifting of fluid from extracellular space to intracellular space will help the baby; this transition should be smooth. Both normal physiologic changes and pathophysiologic events are capable of disrupting this delicate fluid shifting that occurs in very low-birth-weight infants during the first week of life...
December 2023: Curēus
https://read.qxmd.com/read/38242498/gestational-diabetes-and-late-preterm-birth-outcomes-with-and-without-exposure-to-antenatal-corticosteroid
#34
JOURNAL ARTICLE
Sarah A Nazeer, Han-Yang Chen, Suneet P Chauhan, Sean C Blackwell, Baha Sibai, Michal Fishel Bartal
BACKGROUND: Unlike pregestational diabetes, ACOG recommends antenatal corticosteroids in those with GDM at risk for preterm birth. However, this recommendation is based on limited data, only 10.6% of the Antenatal Late Preterm Steroids (ALPS) study sample had GDM. There is a paucity of data on the risk of neonatal respiratory and other morbidity in this population. OBJECTIVE: To examine respiratory outcomes in parturients with GDM who received antenatal corticosteroids and delivered during the late preterm period versus those who did not...
January 17, 2024: American journal of obstetrics & gynecology MFM
https://read.qxmd.com/read/38236433/decrease-in-lipid-metabolic-indexes-in-infants-with-neonatal-respiratory-distress-syndrome
#35
JOURNAL ARTICLE
Guohong Zheng, Jiansheng Zheng, Xiangrong Hu, Tang Zhu
Incomplete pulmonary function and insufficient production of pulmonary surfactant in premature infants may affect alveolar relaxation, inducing neonatal respiratory distress syndrome (NRDS). The present study was a retrospective comparison of lipid metabolism indexes and clinic information between NRDS and non-NRDS infants. Data on general information, pregnancy, clinical symptoms, family history as well as plasma biochemical and lipid metabolic indexes were retrospectively collected and statistically analyzed from 79 patients with NRDS and 44 non-NRDS infants...
February 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38236403/use-of-point-of-care-ultrasound-pocus-to-monitor-neonatal-and-pediatric-extracorporeal-life-support
#36
REVIEW
Stefania Bianzina, Yogen Singh, Roberta Iacobelli, Antonio Amodeo, Yigit Guner, Matteo Di Nardo
Extracorporeal membrane oxygenation (ECMO) is an invasive life support technique that requires a blood pump, an artificial membrane lung, and vascular cannulae to drain de-oxygenated blood, remove carbon dioxide, oxygenate, and return it to the patient. ECMO is generally used to provide advanced and prolonged cardiopulmonary support in patients with refractory acute cardiac and/or respiratory failure. After its first use in 1975 to manage a severe form of meconium aspiration syndrome with resultant pulmonary hypertension, the following years were dominated by the use of ECMO to manage neonatal respiratory failure and limited to a few centers across the world...
January 18, 2024: European Journal of Pediatrics
https://read.qxmd.com/read/38231237/synergistic-effects-of-achieving-perinatal-interventions-on-bronchopulmonary-dysplasia-in-preterm-infants
#37
JOURNAL ARTICLE
Xiang Chen, Lin Yuan, Siyuan Jiang, Xinyue Gu, Xiaoping Lei, Liyuan Hu, Tiantian Xiao, Yanping Zhu, Dan Dang, Wenli Li, Yun Cao, Lizhong Du, Shoo K Lee, Chao Chen, Wenhao Zhou, Jianguo Zhou
UNLABELLED: To investigate the effect of perinatal interventions on the risk of severe BPD (sBPD) and death in extremely preterm infants (EPIs) and their synergistic effects. This was a secondary analysis of the prospective cohort Chinese Neonatal Network (CHNN). Infants with a birth weight of 500 to 1250 g or 24-28 weeks completed gestational age were recruited. The impacts and the synergistic effects of six evidence-based perinatal interventions on the primary outcomes of sBPD and death were assessed by univariate and multivariable logistic regression modeling...
January 17, 2024: European Journal of Pediatrics
https://read.qxmd.com/read/38228632/a-clinical-study-evaluating-the-combination-of-lisa-and-snippv-for-the-treatment-of-respiratory-distress-syndrome-in-preterm-infants
#38
JOURNAL ARTICLE
Dhivya Lakshmi Permall, Yuhan Zhang, Hanyue Li, Yafei Guan, Xiaoqing Chen
To compare the therapeutic effect of less invasive surfactant administration (LISA) followed by synchronized nasal intermittent positive pressure ventilation (SNIPPV) and traditional intubate-Surfactant-Extubate (InSurE) strategy for the treatment of neonatal respiratory distress syndrome (NRDS). A single-center, non-randomized and single- blinded study Tertiary neonatal intensive care unit 89 infants enrolled were preterm with gestational age < 366/7  weeks and clinically diagnosed with neonatal RDS (NRDS) Interventions: 32 infants were assigned to the LISA + SNIPPV group and 57 infants to the InSurE + nCPAP group...
January 16, 2024: Scientific Reports
https://read.qxmd.com/read/38218082/early-red-blood-cell-transfusion-and-the-occurrence-of-intraventricular-hemorrhage-in-very-preterm-infants
#39
JOURNAL ARTICLE
Aleksandra Skubisz, Linda S de Vries, Sophie J Jansen, Hilde van der Staaij, Enrico Lopriore, Sylke J Steggerda
BACKGROUND: Preterm infants are at risk of developing both intraventricular hemorrhage (IVH) and anemia of prematurity. Several studies reported an association between early postnatal red blood cell (RBC) transfusion and IVH, however the timing and causality between these two remains unclear. AIMS: To describe the temporal sequence between administration of early RBC transfusion (within the first week of life) and diagnosis of IVH in very preterm infants. STUDY DESIGN: Retrospective single center case-series...
February 2024: Early Human Development
https://read.qxmd.com/read/38216310/heated-and-humidified-high-flow-therapy-hhhft-in-extreme-and-very-preterm-neonates-with-respiratory-distress-syndrome-rds-a-retrospective-cohort-from-a-tertiary-care-setting-in-pakistan
#40
JOURNAL ARTICLE
Vikram Kumar Kessani, Fatima Hemani, Iqrar Ali, Sana Memon, Albar Soomro, Rija Zaheer, Jai K Das, Khalid N Haque, Syed Rehan Ali
OBJECTIVE: To determine the role of heated humidified high flow therapy (HHHFT) as primary respiratory support in spontaneously breathing moderate-late, very and extreme preterm neonates with respiratory distress syndrome (RDS) at a tertiary care hospital from a developing country. DESIGN: Retrospective cohort study. SETTING: Neonatal intensive care unit of Indus Hospital and Health Network, Karachi, Pakistan. PATIENTS: All preterm neonates with RDS and who received HHHFT as primary respiratory support were included retrospectively, while neonates with orofacial anomalies, congenital heart and lung diseases other than RDS, abdominal wall defects, encephalopathy, congenital pneumonia and received continuous positive airway pressure or invasive ventilation were excluded...
January 12, 2024: BMJ Paediatrics Open
keyword
keyword
93155
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.