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https://www.readbyqxmd.com/read/28794958/saccharomyces-cerevisiae-var-boulardii-fungemia-following-probiotic-treatment
#1
Marcelo C Appel-da-Silva, Gabriel A Narvaez, Leandro R R Perez, Laura Drehmer, Jairo Lewgoy
Probiotics are commonly prescribed as an adjuvant in the treatment of antibiotic-associated diarrhea caused by Clostridium difficile. We report the case of an immunocompromised 73-year-old patient on chemotherapy who developed Saccharomyces cerevisiae var. boulardii fungemia in a central venous catheter during treatment of antibiotic-associated pseudomembranous colitis with the probiotic Saccharomyces cerevisiae var. boulardii. Fungemia was resolved after interruption of probiotic administration without the need to replace the central venous line...
December 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28678976/probiotic-therapy-reduces-inflammation-and-improves-intestinal-morphology-in-rats-with-induced-oral-mucositis
#2
Dayana Gerhard, Frederico José da Silva Simão de Sousa, Rodrigo Antonio Carvalho Andraus, Paulo Eduardo Pardo, Gisele Alborguetti Nai, Hermann Bremer Neto, Michel Reis Messora, Luciana Prado Maia
The aim of the present study was to evaluate the effect of systemic administration of probiotics (PROB) on the progression of experimentally induced oral and intestinal mucositis in rats immunosuppressed by chemotherapy (5-fluorouracil: 5-FU). Twenty-four rats were divided into the following groups (n=6): GC (control), GPROB, G5FU and G5-FU/PROB. Groups GPROB and G5-FU/PROB received 1 g of probiotic incorporated into each 100 g of feed (Bacillus subtilis, Bifidobacterium bifidum, Enterococcus faecium and Lactobacilllus acidophilus), beginning 30 days before oral mucositis induction...
July 3, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28640662/using-probiotics-in-clinical-practice-where-are-we-now-a-review-of-existing-meta-analyses
#3
Mariangela Rondanelli, Milena Anna Faliva, Simone Perna, Attilio Giacosa, Gabriella Peroni, Anna Maria Castellazzi
The scientific literature has demonstrated that probiotics have a broad spectrum of activity, although often the results are contradictory. This study provides a critical overview of the current meta-analyses that have evaluated the efficacy of probiotics in physiologic and pathological conditions, such as metabolic disease, antibiotic-associated and Clostridium difficile-associated diarrhea, IBS, constipation, IBD, chemotherapy-associated diarrhea, respiratory tract infection, ventilator-associated pneumonia, NAFLD, liver encephalopathy, periodontitis, depression, vaginosis, urinary tract infections, pancreatitis, incidence of ventilator-associated pneumonia, hospital infection and stay in ICU, mortality of post-trauma patients, necrotising enterocolitis in premature infants...
June 22, 2017: Gut Microbes
https://www.readbyqxmd.com/read/28590519/probiotic-bifidobacterium-bifidum-g9-1-attenuates-5-fluorouracil-induced-intestinal-mucositis-in-mice-via-suppression-of-dysbiosis-related-secondary-inflammatory-responses
#4
Shinichi Kato, Nahla Hamouda, Yoshitaro Kano, Yousuke Oikawa, Yoshiki Tanaka, Kenjiro Matsumoto, Kikuko Amagase, Masaki Shimakawa
Bifidobacterium, a major component of the intestinal microbiota, has been clinically used for the treatment of diarrhoea and constipation. 5-Fluorouracil (5-FU), widely used for cancer chemotherapy, is known to frequently induce intestinal mucositis accompanied by severe diarrhoea. The present study examined the effect of Bifidobacterium bifidum G9-1 (BBG9-1) on 5-FU-induced intestinal mucositis in mice. Intestinal mucositis was induced by repeated administration of 5-FU for 6 days. BBG9-1 was administered orally once daily for 9 days, beginning 3 days before the onset of 5-FU treatment...
June 7, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28588016/commensal-microbes-provide-first-line-defense-against-listeria-monocytogenes-infection
#5
Simone Becattini, Eric R Littmann, Rebecca A Carter, Sohn G Kim, Sejal M Morjaria, Lilan Ling, Yangtsho Gyaltshen, Emily Fontana, Ying Taur, Ingrid M Leiner, Eric G Pamer
Listeria monocytogenes is a foodborne pathogen that causes septicemia, meningitis and chorioamnionitis and is associated with high mortality. Immunocompetent humans and animals, however, can tolerate high doses of L. monocytogenes without developing systemic disease. The intestinal microbiota provides colonization resistance against many orally acquired pathogens, and antibiotic-mediated depletion of the microbiota reduces host resistance to infection. Here we show that a diverse microbiota markedly reduces Listeria monocytogenes colonization of the gut lumen and prevents systemic dissemination...
July 3, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28275899/spray-dried-formulation-of-5-fluorouracil-embedded-with-probiotic-biomass-in-vitro-and-in-vivo-studies
#6
Anshul Sharma, Malika Arora, Amit K Goyal, Goutam Rath
The present study is utilizing the targeted therapeutic approach and antioxidant potential of selected probiotic biomass in mitigating toxic side effects of chemotherapeutic agents. Multicomponent carrier system consisting of 5-fluorouracil (5-FU) and selected probiotic strain with higher free radical scavenging activity was prepared using spray drying technique. Prepared spray dried microparticles were characterized for various physical, pharmaceutical, and biopharmaceutical properties including particle size, moisture content, entrapment efficiency, in vitro drug release, DSC, XRD, cell uptake, histopathology, and pharmacokinetic studies...
March 8, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/28212560/use-of-complementary-and-alternative-medicine-cam-in-cancer-patients-an-italian-multicenter-survey
#7
Massimiliano Berretta, Chiara Della Pepa, Paolo Tralongo, Alberto Fulvi, Ferdinando Martellotta, Arben Lleshi, Guglielmo Nasti, Rossella Fisichella, Carmela Romano, Chiara De Divitiis, Rosaria Taibi, Francesco Fiorica, Raffaele Di Francia, Anna Di Mari, Lino Del Pup, Anna Crispo, Paolo De Paoli, Adriano Santorelli, Vincenzo Quagliariello, Rosario Vincenzo Iaffaioli, Umberto Tirelli, Gaetano Facchini
INTRODUCTION: Complementary and Alternative Medicine (CAM) include a wide range of products (herbs, vitamins, minerals, and probiotics) and medical practices, developed outside of the mainstream Western medicine. Patients with cancer are more likely to resort to CAM first or then in their disease history; the potential side effects as well as the costs of such practices are largely underestimated. PATIENTS AND METHOD: We conducted a descriptive survey in five Italian hospitals involving 468 patients with different malignancies...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28118611/the-influence-of-neoadjuvant-chemotherapy-on-gastric-cancer-patients-postoperative-infectious-complications-what-is-the-negative-role-played-by-the-intestinal-barrier-dysfunction
#8
Zhiliang Wei, Bin Tan, Shougen Cao, Shanglong Liu, Xiaojie Tan, Zengwu Yao, Na Yin, Jiante Li, Dongfeng Zhang, Yanbing Zhou
Evidence has shown that neoadjuvant chemotherapy (NACT) is correlated with patients' overall postoperative complications. But investigations on relationship between NACT and postoperative infectious complications, which is closely linked to intestinal barrier damage, were scanty. Accordingly, 90 patients with advanced gastric cancer were included in this study. The differences in postoperative infectious complications were determined between NACT group in which patients received NACT before surgery and SURG group in which received surgical treatment immediately after diagnosis...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28106826/colorectal-carcinoma-a-general-overview-and-future-perspectives-in-colorectal-cancer
#9
REVIEW
Inés Mármol, Cristina Sánchez-de-Diego, Alberto Pradilla Dieste, Elena Cerrada, María Jesús Rodriguez Yoldi
Colorectal cancer (CRC) is the third most common cancer and the fourth most common cause of cancer-related death. Most cases of CRC are detected in Western countries, with its incidence increasing year by year. The probability of suffering from colorectal cancer is about 4%-5% and the risk for developing CRC is associated with personal features or habits such as age, chronic disease history and lifestyle. In this context, the gut microbiota has a relevant role, and dysbiosis situations can induce colonic carcinogenesis through a chronic inflammation mechanism...
January 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27994577/metabiotics-one-step-ahead-of-probiotics-an-insight-into-mechanisms-involved-in-anticancerous-effect-in-colorectal-cancer
#10
REVIEW
Mridul Sharma, Geeta Shukla
Colorectal cancer is closely associated with environment, diet and lifestyle. Normally it is treated with surgery, radiotherapy or chemotherapy but increasing systemic toxicity, resistance and recurrence is prompting scientists to devise new potent and safer alternate prophylactic or therapeutic strategies. Among these, probiotics, prebiotics, synbiotics, and metabiotics are being considered as the promising candidates. Metabiotics or probiotic derived factors can optimize various physiological functions of the host and offer an additional advantage to be utilized even in immunosuppressed individuals...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27542618/probiotics-as-an-environment-friendly-approach-to-enhance-red-sea-bream-pagrus-major-growth-immune-response-and-oxidative-status
#11
Mahmoud A O Dawood, Shunsuke Koshio, Manabu Ishikawa, Mabrouk El-Sabagh, M Angeles Esteban, Amr I Zaineldin
A usual strategy in modern aquaculture to combat production bottlenecks associated with intensification is preventive health care through the use of consumer and environment-friendly alternatives including probiotics. The current study evaluates the influence of Lactobacillus rhamnosus (LR), a lyophilized probiotic bacterium, on health status and performance of red sea bream (Pagrus major). Probiotics were incorporated in the diets at four different concentrations: 0 (control diet, LR0), 10(2) (LR1), 10(4) (LR2) and 10(6) (LR3) cells g(-1) and diets were administered to the fish for a period of 8 weeks...
October 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27427511/administration-of-probiotic-mixture-dm-1-ameliorated-5-fluorouracil-induced-intestinal-mucositis-and-dysbiosis-in-rats
#12
Yan Tang, Yingtao Wu, Ziyi Huang, Weiwei Dong, Ying Deng, Fengjiao Wang, Ming Li, Jieli Yuan
OBJECTIVE: The use of probiotics to alleviate chemotherapy-induced intestinal mucositis is supported by clinical consensus. However, no studies to date, to our knowledge, have systematically analyzed the effects of a probiotic mixture on chemotherapy-induced mucositis or assessed changes in the intestinal microbiota after probiotic treatment. The aim of this study was to report the effects of a probiotic mixture, DM#1, on intestinal mucositis and dysbiosis of rats treated with 5-fluorouracil (5-FU)...
January 2017: Nutrition
https://www.readbyqxmd.com/read/27329608/the-efficacy-and-safety-of-probiotics-for-prevention-of-chemoradiotherapy-induced-diarrhea-in-people-with-abdominal-and-pelvic-cancer-a-systematic-review-and-meta-analysis
#13
REVIEW
Y-H Wang, N Yao, K-K Wei, L Jiang, S Hanif, Z-X Wang, C-X Pei
A systematic review and meta-analysis were designed to evaluate the efficacy and safety of probiotics for prevention of chemoradiotherapy-induced diarrhea in people with abdominal and pelvic cancer. We searched the Cochrane Library, PubMed, EMBASE and Web of Science up to November 2015. We also hand searched the citation lists of included studies and previously identified systematic reviews to identify further relevant trials. Odds ratio (OR) was used to compare efficacy, and the pooled OR was estimated using a random effects model; heterogeneity was assessed with Cochran's Q and the Higgins' I(2)-test...
November 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27221111/combination-therapy-of-lactobacillus-plantarum-supernatant-and-5-fluouracil-increases-chemosensitivity-in-colorectal-cancer-cells
#14
JaeJin An, Eun-Mi Ha
Colorectal cancer (CRC) is the third most common cancer in the world. Although 5-fluorouracil (5-FU) is the representative chemotherapy drug for colorectal cancer, it has therapeutic limits due to its chemoresistant characteristics. Colorectal cancer cells can develop into cancer stem cells (CSCs) with self-renewal potential, thereby causing malignant tumors. The human gastrointestinal tract contains a complex gut microbiota that is essential for the host's homeostasis. Recently, many studies have reported correlations between gut flora and the onset, progression, and treatment of CRC...
August 28, 2016: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27151581/probiotic-survey-in-cancer-patients-treated-in-the-outpatient-department-in-a-comprehensive-cancer-center
#15
Sona Ciernikova, Michal Mego, Maria Semanova, Lenka Wachsmannova, Zuzana Adamcikova, Viola Stevurkova, Lubos Drgona, Vladimir Zajac
PURPOSE: Availability without prescription restriction, low cost, and simple oral administration allow cancer patients to use probiotics without knowledge of potential risks. We present a survey of probiotic use and the association with patient tumor characteristics in cancer patients treated at the outpatient department of the National Cancer Institute in Slovakia. PATIENTS AND METHODS: Between March and December 2014, 499 patients were asked to evaluate their overall experience with probiotics by questionnaire form, including the length and method of use relative to anticancer therapy, expectations, side-effect experiences, understanding of the possible risks, dietary supplement use, and others...
June 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27144297/the-potential-role-of-probiotics-in-cancer-prevention-and-treatment
#16
Ai-Qun Yu, Lianqin Li
The human gut microbiota has a significant effect on many aspects of human physiology such as metabolism, nutrient absorption, and immune function. Imbalance of the microbiota has been implicated in many disorders including inflammatory bowel disease, obesity, asthma, psychiatric illnesses, and cancers. As a kind of functional foods, probiotics have been shown to play a protective role against cancer development in animal models. Clinical application of probiotics indicated that some probiotic strains could diminish the incidence of postoperative inflammation in cancer patients...
May 2016: Nutrition and Cancer
https://www.readbyqxmd.com/read/27137071/characterization-of-pediococcus-acidilactici-strains-isolated-from-rainbow-trout-oncorhynchus-mykiss-feed-and-larvae-safety-dna-fingerprinting-and-bacteriocinogenicity
#17
Carlos Araújo, Estefanía Muñoz-Atienza, Patrícia Poeta, Gilberto Igrejas, Pablo E Hernández, Carmen Herranz, Luis M Cintas
The use of lactic acid bacteria (LAB) as probiotics constitutes an alternative or complementary strategy to chemotherapy and vaccination for disease control in aquaculture. The objectives of this work were (1) the in vitro safety assessment of 8 Pediococcus acidilactici strains isolated from rainbow trout (Oncorhynchus mykiss, Walbaum) feed and larvae; (2) the evaluation of their genetic relatedness; (3) the study of their antimicrobial/bacteriocin activity against fish pathogens; and (4) the biochemical and genetic characterization of the bacteriocin produced by the strain displaying the greatest antimicrobial activity...
May 3, 2016: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/27133563/saccharomyces-cerevisiae-ufmg-a-905-treatment-reduces-intestinal-damage-in-a-murine-model-of-irinotecan-induced-mucositis
#18
R W Bastos, S H S P Pedroso, A T Vieira, L M C Moreira, C S França, C T Cartelle, R M E Arantes, S V Generoso, V N Cardoso, M J Neves, J R Nicoli, F S Martins
Indigenous microbiota plays a crucial role in the development of several intestinal diseases, including mucositis. Gastrointestinal mucositis is a major and serious side effect of cancer therapy, and there is no effective therapy for this clinical condition. However, some probiotics have been shown to attenuate such conditions. To evaluate the effects of Saccharomyces cerevisiae UFMG A-905 (Sc-905), a potential probiotic yeast, we investigated whether pre- or post-treatment with viable or inactivated Sc-905 could prevent weight loss and intestinal lesions, and maintain integrity of the mucosal barrier in a mucositis model induced by irinotecan in mice...
September 2016: Beneficial Microbes
https://www.readbyqxmd.com/read/27003991/vaccine-against-helicobacter-pylori-inevitable-approach
#19
REVIEW
Amin Talebi Bezmin Abadi
Over three decades have passed since the discovery of Helicobacter pylori (H. pylori), and yet many questions about its treatment remain unanswered. For example, there is no certainty regarding continued use of current antibiotic therapy against H. pylori. The bad news is that even combined regimens are also unable to eradicate bacterial colonization. The worst problem with H. pylori chemotherapy is that even if we identify the most successful regimen, it cannot eliminate the risk of re-infection. This problem is further complicated by the fact that clinicians have no information as to whether probiotics are useful or not...
March 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26782606/evolving-roles-of-probiotics-in-cancer-prophylaxis-and-therapy
#20
Seema Patel, Arun Goyal
In nutraceutical science, the ingestible live microbes 'probiotics' are regarded for their ability to confer multiplicity of health benefits on the consumers. Wide spectrum impact of these friendly microbes on the host health has been proved very frequently. They have been confirmed to boost immunity, aid in digestion, eliminate pathogens, curb inflammatory bowel diseases, moderate side effects of antibiotic therapy, lower cholesterol and blood glycemic index and produce vitamins. This review, however, focuses on the incipient, but promising area of probiotic diet-based prevention and remedy of cancer...
March 2013: Probiotics and Antimicrobial Proteins
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