Regina Lucia Dos Santos Silva, Thae Lanne Barbosa Gama Lins, Alane Pains Oliveira do Monte, Kíscyla Oliveira de Andrade, Ricássio de Sousa Barberino, Gizele Augusta Lemos Silva, Daniela da Silva Pereira Campinho, Raimundo Campos Palheta Junior, Maria Helena Tavares de Matos
The aims of the present study were to evaluate the protective effects of gallic acid against doxorubicin-induced ovarian toxicity in mice, and to verify the possible involvement of PI3K and mTOR signaling pathway members (PTEN, Akt, FOXO3a and rpS6) in the gallic acid protective actions. Mice were pretreated with NaCl (0.15M, p.o.) (control and doxorubicin groups) or gallic acid (50, 100 or 200mg/kg body weight, p.o.) once daily, for 5 days, and on the third day of treatment, after 1h of treatment administration, the mice received saline solution (i...
December 23, 2022: Reproductive Toxicology