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https://www.readbyqxmd.com/read/27936497/pro-inflammatory-cytokine-ifn%C3%AE-and-microbiome-derived-metabolites-dictate-epigenetic-switch-between-foxp3-isoforms-in-celiac-disease-regulation-of-foxp3-isoforms-in-celiac-disease
#1
Gloria Serena, Shu Yan, Stephanie Camhi, Shilpi Patel, Rosiane S Lima, Anna Sapone, Maureen M Leonard, Rupa Mukherjee, Barbara J Nath, Karen M Lammers, Alessio Fasano
Celiac disease (CD) is an autoimmune enteropathy triggered by gluten and characterized by a strong Th1/Th17 immune response in the small intestine. Treg cells are CD4(+) CD25(++) FOXP3(+) cells that regulate the immune response. Conversely to its counterpart, FOXP3 full length (FL), the alternatively spliced isoform FOXP3 Δ2 cannot properly down-regulate Th17 driven immune response. Since the active state of CD has been associated with impairments in Treg cell function, we aimed at determining whether imbalances between FOXP3 isoforms may be associated with the disease...
December 9, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27936420/myofibroblastoma-of-the-male-breast-a-rare-entity-with-radiologic-pathologic-correlation
#2
John D Comer, Xiaoyan Cui, Carolyn Sharyn Eisen, Genevieve Abbey, Elizabeth Kagan Arleo
A 73-year old man with a history of multiple genitourinary malignancies was found to have a left retroareolar soft tissue mass on CT assessment of disease, and dedicated breast imaging was recommended. Diagnostic mammography and ultrasonography confirmed a solid mass, for which biopsy was recommended. Pathologic analysis demonstrated a spindle cell neoplasm with an immunoreactivity pattern consistent with myofibroblastoma. While this entity is benign, nonspecific imaging features necessitate tissue sampling for pathologic diagnosis, and, given pathologic rarity, open communication between the radiologist and pathologist is important to establish the correct diagnosis and to recommend appropriate management...
November 30, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27936419/unexplained-gastrointestinal-bleed-due-to-arteriobiliary-fistula-after-percutaneous-liver-biopsy
#3
John Smirniotopoulos, Paul Barone, Marc Schiffman
We represent a case of a 54-year-old male who presented to the emergency department with right upper quadrant abdominal pain and melena three weeks after percutaneous liver biopsy. He was found to have anemia secondary to an upper gastrointestinal hemorrhage, unresponsive to multiple blood transfusions. Angiography later revealed an arteriobiliary fistula with contrast extravasation entering the duodenum. The fistula was successfully embolized and the patient was discharged without complication. This report demonstrates the importance in considering a vascular intrahepatic fistula in patients with right upper quadrant abdominal pain after remote liver biopsy...
December 5, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27936280/application-of-the-combined-fibrometer-vcte-algorithm-in-chinese-patients-with-nonalcoholic-fatty-liver-disease
#4
Thomson Chi-Wang Loong, Jeremy Lok Wei, Jonathan Chung-Fai Leung, Grace Lai-Hung Wong, Sally She-Ting Shu, Angel Mei-Ling Chim, Anthony Wing-Hung Chan, Paul Cheung-Lung Choi, Yee-Kit Tse, Henry Lik-Yuen Chan, Vincent Wai-Sun Wong
BACKGROUND AND AIM: The FM VCTE is a new formula combining the serum test FibroMeter (FM) and liver stiffness measurement (LSM) by vibration controlled transient elastography (VCTE). We tested the accuracy and utility of FM VCTE for fibrosis staging in patients with non-alcoholic fatty liver disease (NAFLD). METHODS: 215 NAFLD patients with LSM, FM NAFLD, FM VCTE and other serum tests (aspartate aminotransferase [AST]-to-platelet ratio index, FIB-4 index, BARD score, NAFLD fibrosis score and AST-to-alanine aminotransferase ratio) performed 1 day before liver biopsy were evaluated...
December 9, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27936121/impact-of-reclassification-on-thyroid-nodules-with-architectural-atypia-from-non-invasive-encapsulated-follicular-variant-papillary-thyroid-carcinomas-to-non-invasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features
#5
Min Ji Jeon, Dong Eun Song, Chan Kwon Jung, Won Gu Kim, Hyemi Kwon, Yu-Mi Lee, Tae-Yon Sung, Jong Ho Yoon, Ki-Wook Chung, Suck Joon Hong, Jung Hwan Baek, Jeong Hyun Lee, Tae Yong Kim, Young Kee Shong, Won Bae Kim
BACKGROUND: The follicular variant of papillary thyroid cancer (FVPTC), especially the encapsulated non-invasive subtype, is a controversial entity. Recent study suggested using 'non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)' for these indolent carcinomas. We evaluated the impact of reclassification from non-invasive encapsulated FVPTCs (EFVPTCs) to NIFTPs in the diagnosis of thyroid nodules with architectural atypia. METHODS: We reviewed 1301 thyroid nodules with architectural atypia in core needle biopsy (CNB) specimens obtained from March 2012 to February 2013...
2016: PloS One
https://www.readbyqxmd.com/read/27936091/development-of-serum-marker-models-to-increase-diagnostic-accuracy-of-advanced-fibrosis-in-nonalcoholic-fatty-liver-disease-the-new-linki-algorithm-compared-with-established-algorithms
#6
Byron Lykiardopoulos, Hannes Hagström, Mats Fredrikson, Simone Ignatova, Per Stål, Rolf Hultcrantz, Mattias Ekstedt, Stergios Kechagias
BACKGROUND AND AIM: Detection of advanced fibrosis (F3-F4) in nonalcoholic fatty liver disease (NAFLD) is important for ascertaining prognosis. Serum markers have been proposed as alternatives to biopsy. We attempted to develop a novel algorithm for detection of advanced fibrosis based on a more efficient combination of serological markers and to compare this with established algorithms. METHODS: We included 158 patients with biopsy-proven NAFLD. Of these, 38 had advanced fibrosis...
2016: PloS One
https://www.readbyqxmd.com/read/27935989/brcaness-and-prognosis-in-triple-negative-breast-cancer-patients-treated-with-neoadjuvant-chemotherapy
#7
Hirokazu Tanino, Yoshimasa Kosaka, Hiroshi Nishimiya, Youko Tanaka, Naoko Minatani, Mariko Kikuchi, Akiko Shida, Mina Waraya, Hiroshi Katoh, Takumo Enomoto, Norihiko Sengoku, Sabine Kajita, Robert M Hoffman, Masahiko Watanabe
BRCAness is defined as the set of traits in which BRCA1 dysfunction, arising from gene mutation, methylation or deletion, results in DNA repair deficiency. In the present study, we addressed BRCAness, therapeutic efficacy, recurrence, and survival in patients with triple negative breast cancer (TNBC) who were treated with neoadjuvant chemotherapy at Kitasato University Hospital, Japan, between April 2006 and October 2012. BRCAness was determined by preoperative core needle biopsy (CNB) specimens and surgical specimens...
2016: PloS One
https://www.readbyqxmd.com/read/27935932/early-recognition-of-fibrodysplasia-ossificans-progressiva-important-for-the-clinician
#8
A Singh, G Pradhan, C Kumari, S Kapoor
Fibrodysplasia ossificans progressiva is a rare disorder of heterotopic ossification. Procedures like biopsy and surgery are known to be aggravating factors in promoting heterotopic ossification Clues to clinical diagnosis may therefore be a great advantage to treating orthopedician. Valgus deformity of great toe is an important diagnostic clue for treating physicians and thus aids in preventing the clinicians from subjecting the patients to unnecessary invasive and traumatic procedures. Hence clinical clues to early diagnosis are important in establishing the correct diagnosis and directing future management...
April 2016: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/27935919/hysteroscopy-in-abnormal-uterine-bleeding-vs-ultrasonography-and-histopathology-report-in-perimenopausal-and-postmenopausal-women
#9
J Sharma, S Tiwari
INTRODUCTION: Abnormal uterine bleeding is one of the most common morbidity landing women to attend medical attention in gynecology outpatient department. This study aims to evaluate the hysteroscopy finding in diagnosis of AUB and its correlation with ultrasonography finding and histopathological reports. METHODS: This was a prospective comparative study in which ultrasonography was performed in fifty patients with abnormal uterine bleeding attending OPD then hysteroscopy was performed...
July 2016: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/27935910/ascites-and-adnexal-mass-with-raised-ca125-how-arduous-can-be-the-path-of-diagnosis
#10
D Pannu, S Malik, S Shamsunder, A Bhatnagar
Ascites, adnexal mass and elevated CA125 levels almost always suggest advanced ovarian carcinoma. We present a case of a 37 years old multiparous lady who presented with such a classical picture. Radiological picture was suggestive of ovarian carcinoma with peritoneal metastasis. However, ascitic fluid cytology was negative for malignant cells. A differential diagnosis of tubercular mass was made. Ascitic fluid was sent for adenosine deaminase test that was negative. Fine needle aspiration cytology failed to reveal any sufficient sample for evaluation...
January 2016: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/27935521/leucine-supplementation-enhances-integrative-myofibrillar-protein-synthesis-in-free-living-older-men-consuming-lower-and-higher-protein-diets-a-parallel-group-crossover-study
#11
Caoileann H Murphy, Nelson I Saddler, Michaela C Devries, Chris McGlory, Steven K Baker, Stuart M Phillips
BACKGROUND: Leucine co-ingestion with lower-protein (LP)-containing meals may overcome the blunted muscle protein synthetic response to food intake in the elderly but may be effective only in individuals who consume LP diets. OBJECTIVE: We examined the impact of leucine co-ingestion with mixed macronutrient meals on integrated 3-d rates of myofibrillar protein synthesis (MyoPS) in free-living older men who consumed higher protein (HP) (1.2 g · kg(-1) · d(-1)) or LP (0...
December 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27935335/pediatric-chondromyxoid-fibroma-like-osteosarcoma
#12
Matthew Stark, Stephen D Heinrich, Raju Sivashanmugam, Dane Mackey, Ewa Wasilewska, Randall Craver
Chondromyxoid fibroma-like osteosarcoma (CMF-OS) is a low-grade osteosarcoma, often misdiagnosed on initial biopsy as a benign lesion, with five cases previously described. We report a 13-year-old male with an intramedullary lytic CMF-OS of the right tibial proximal metaphysis with cortical destruction and soft tissue extension. Diagnosis was based on malignant new bone formation, increased mitotic figures, lamellar bone permeation with bony destruction, and correlation with imaging studies. There were no metastasis at presentation and the tumor showed good response to standard chemotherapy with >95% necrosis...
December 9, 2016: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/27935231/prolonged-tacrolimus-use-for-pediatric-gastrointestinal-disorder-a-double-edged-sword
#13
Kenji Hosoi, Katsuhiro Arai, Kentaro Matsuoka, Hirotaka Shimizu, Koichi Kamei, Atsuko Nakazawa, Toshiaki Shimizu, Julian Tang, Shuichi Ito
BACKGROUND: Although tacrolimus (TAC) appeared useful in inducing remission in children with refractory inflammatory bowel disease (IBD) or autoimmune gastroenteropathy (AGE), its use in maintenance therapy remains controversial. The aim of this study was to reveal the potential nephrotoxic nature of prolonged TAC use. METHODS: This retrospective study reviews children with gastrointestinal disorder who underwent kidney biopsy for the evaluation of renal damage during TAC therapy of over one year...
December 9, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27935172/acl-injury-reduces-satellite-cell-abundance-and-promotes-fibrogenic-cell-expansion-within-skeletal-muscle
#14
Christopher S Fry, Darren L Johnson, Mary Lloyd Ireland, Brian Noehren
Anterior cruciate ligament (ACL) injuries are associated with significant loss of strength in knee extensor muscles that persists despite physical therapy. The underlying mechanisms responsible for this protracted muscle weakness are poorly understood; however, we recently showed significant myofiber atrophy and altered muscle phenotype following ACL injury. We sought to further explore perturbations in skeletal muscle morphology and progenitor cell activity following an ACL injury. Muscle biopsies were obtained from the injured and non-injured vastus lateralis of young adults (n = 10) following ACL injury, and histochemical/immunohistochemical analyses were undertaken to determine collagen content, abundance of connective tissue fibroblasts, fibrogenic/adipogenic progenitor (FAP) cells, satellite cells, in addition to indices of muscle fiber denervation and myonuclear apoptosis...
December 9, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27935120/prevalence-of-high-risk-human-papillomavirus-infection-among-women-in-shaanxi-province-of-china-a-hospital-based-investigation
#15
Di Cao, Shaohua Zhang, Qian Zhang, Xing Wei, Minyi Zhao, Qian Ma, Yang Li, Li Wang, Meili Pei, Ting Yang, Juan Zhao, Xiaofeng Yang
OBJECTIVE: To investigate the characteristics of female high-risk human papillomavirus (HR-HPV) infection in Shaanxi province of China. METHODS: A total of 14,111 women were enrolled for HPV genotyping test, and a cytology and/or cervix biopsy were performed in partial women. RESULTS: Of these women, the HPV infection rate was 30.21%, and 26.73% were caused by HR-HPV. The most common HR-HPV genotypes were HPV-16, HPV-58, HPV-52, HPV-18 and HPV-31...
December 9, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27935086/exercise-responses-in-patients-with-chronically-high-creatine-kinase-levels
#16
Christopher B Cooper, Brett A Dolezal, Eric V Neufeld, Perry Shieh, John R Jenner, Marshall Riley
INTRODUCTION: Elevated serum creatine kinase (CK) is often taken to reflect muscle disease, but many individuals have elevated CK without a specific diagnosis. How elevated CK reflects muscle metabolism during exercise is not known. METHODS: Participants (46 men, 48 women) underwent incremental exercise testing to assess aerobic performance, cardiovascular response, and ventilatory response. Serum lactate, ammonia, and CK were measured at rest, 4 minutes into exercise, and 2 minutes into recovery...
December 9, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27935078/ischemic-myopathy-revealing-systemic-calciphylaxis
#17
Jessie Aouizerate, Laurence Valleyrie-Allanore, Nicolas Limal, S Samar Ayache, Romain K Gherardi, Vincent Audard, François Jérôme Authier
INTRODUCTION: Patients with renal failure who are being treated with dialysis frequently develop neuromuscular manifestations. Renal failure-associated calciphylaxis, also termed calcific uremic arteriolopathy (CUA), is a life-threatening condition usually observed in patients with end-stage renal disease on chronic dialysis or following renal transplantation. METHODS: We describe a hemodialyzed patient who presented with rapidly progressive unexplained systemic vasculopathy, muscle atrophy, and proximal weakness, that unexpectedly proved to be caused by calciphylaxis...
December 9, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27935036/sentinel-node-metastasis-mitotic-rate-sn-mmr-as-a-prognostic-indicator-of-rapidly-progressing-disease-in-patients-with-sentinel-node-positive-melanomas
#18
Cornelia Baum, Christel Weiss, Christoffer Gebhardt, Jochen Utikal, Alexander Marx, Wolfgang Koenen, Cyrill Géraud
Risk stratification of sentinel lymph node biopsy (SNB)-positive patients with malignant melanoma differs among current classification systems. To improve classification of patients with rapidly progressive disease who may profit from adjuvant therapy with novel immune or targeted treatment modalities, a single-center retrospective analysis was performed including all melanoma patients diagnosed with a positive SN at a university-based skin cancer center over a 10-year period (2002-2012) (96 of 419 patients)...
December 9, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27934896/transient-appearance-of-circulating-tumor-dna-associated-with-de-novo-treatment
#19
Kikuya Kato, Junji Uchida, Yoji Kukita, Toru Kumagai, Kazumi Nishino, Takako Inoue, Madoka Kimura, Fumio Imamura
The limitation of circulating tumor DNA (ctDNA) is its inability to detect cancer cell subpopulations with few or no dying cells. Lung cancer patients subjected to the EGFR tyrosine kinase inhibitor (EGFR-TKI) treatment were prospectively collected, and ctDNA levels represented by the activating and T790M mutations were measured. The first data set (21 patients) consisting of samples collected in the period from before initiation of EGFR-TKI to at least 2 weeks after initiation: the ctDNA dynamics generally exhibited a rapid decrease and/or a transient increase...
December 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27934876/immunohistochemistry-for-p53-is-a-useful-tool-to-identify-cases-of-acute-myeloid-leukemia-with-myelodysplasia-related-changes-that-are-tp53-mutated-have-complex-karyotype-and-have-poor-prognosis
#20
Sebastian Fernandez-Pol, Lisa Ma, Robert S Ohgami, Daniel A Arber
In this study, we evaluate the expression of p53 in core biopsies with acute myeloid leukemia and correlate the level of expression with acute myeloid leukemia subtype, TP53 mutation status, karyotype, and survival. Of the 143 cases evaluated, 71 fulfilled the WHO 2016 criteria for acute myeloid leukemia with myelodysplasia-related changes, 40 were acute myeloid leukemia-not otherwise specified, 25 were acute myeloid leukemia with recurrent genetic abnormalities, and 7 were therapy-related acute myeloid leukemia...
December 9, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
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