Xiao-Yu Bai, Xue-Qiong Zhang, Yong-He Zhang, Song Wu, Ling-Hua Hao, Rui Liu, Zhong-Lin Huang, Wei-Ku Zhang, Zong-Miao Sun, Guan-Hua Du
To characterize the sedative and hypnotic profile of the novel adenosine derivative ((3S,4R,5R)-3,4-dihydroxy-5-(6-((4-hydroxy-3-methoxybenzyl)amino)-9H-purin-9-yl)tetrahydrofuran-2-yl) methyl diaconate (WS0701), we performed a variety of behavioural tests and investigated the influence of WS0701 on various sleep stages. In mice, WS0701 significantly increased the number of entries and time spent in open arms in the elevated plus maze test, indicating an anxiolytic effect. WS0701 decreased locomotor activity counts and head dips in the hole-board test and enhanced sodium pentobarbital-induced hypnosis...
October 2014: Behavioural Pharmacology