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willms tumor

Eduard Willms, Carlos Cabañas, Imre Mäger, Matthew J A Wood, Pieter Vader
Cells release membrane enclosed nano-sized vesicles termed extracellular vesicles (EVs) that function as mediators of intercellular communication by transferring biological information between cells. Tumor-derived EVs have emerged as important mediators in cancer development and progression, mainly through transfer of their bioactive content which can include oncoproteins, oncogenes, chemokine receptors, as well as soluble factors, transcripts of proteins and miRNAs involved in angiogenesis or inflammation...
2018: Frontiers in Immunology
Karen Legler, Charlotte Hauser, Jan-Hendrik Egberts, Anna Willms, Carola Heneweer, Susann Boretius, Christoph Röcken, Claus-Christian Glüer, Thomas Becker, Michael Kluge, Oliver Hill, Christian Gieffers, Harald Fricke, Holger Kalthoff, Johannes Lemke, Anna Trauzold
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has raised attention as a novel anticancer therapeutic as it induces apoptosis preferentially in tumor cells. However, first-generation TRAIL-receptor agonists (TRAs), comprising recombinant TRAIL and agonistic receptor-specific antibodies, have not demonstrated anticancer activity in clinical studies. In fact, cancer cells are often resistant to conventional TRAs. Therefore, in addition to TRAIL-sensitizing strategies, next-generation TRAs with superior apoptotic activity are warranted...
April 18, 2018: Cell Death & Disease
A Fucic, V Guszak, A Mantovani
Biological responses to carcinogens from environmental exposure during adulthood are modulated over years or decades. Conversely, during transplacental exposure, the effects on the human foetus change within weeks, intertwining with developmental mechanisms: even short periods of transplacental exposure may be imprinted in the organism for a lifetime. The pathways leading to childhood and juvenile cancers, such as leukaemias, neuroblastoma/brain tumours, hepatoblastoma, and Willm's tumour involve prenatally-induced genomic, epigenomic and/or non-genomic effects caused by xenobiotics...
June 15, 2017: Reproductive Toxicology
Christoph Willmes, Rajiv Kumar, Jürgen C Becker, Isabella Fried, P Sivaramakrishna Rachakonda, Lidia M Poppe, Sonja Hesbacher, Dirk Schadendorf, Antje Sucker, David Schrama, Selma Ugurel
Despite of highly effective new therapeutic strategies, chemotherapy still is an important treatment option in metastatic melanoma. Since predictors of chemotherapy response are rare, drugs and regimens are currently chosen arbitrarily. The present study was aimed at the identification of molecular markers predicting the outcome of chemotherapy in melanoma. Tumor biopsies from metastatic lesions were collected from 203 stage IV melanoma patients prior to chemotherapy onset and used for gene expression profiling (n = 6; marker identification set), quantitative real-time PCR (n = 127; validation set 1), and immunohistochemistry on tissue microarrays (n = 70; validation set 2)...
March 1, 2016: Oncotarget
Henrike Julich, Arnulf Willms, Veronika Lukacs-Kornek, Miroslaw Kornek
Cell-derived vesicles in particular extracellular vesicles (EVs) such as microparticles (MPs) and microvesicles besides exosomes are raising more and more attention as a novel and unique approach to detect diseases. It has recently become apparent that disease specific MP signatures or profiles might be beneficial to differentiate chronic liver diseases such as non-alcoholic fatty liver disease and chronic hepatitis C, to monitor their progression or possibly to assess treatment outcome. Therefore EVs might serve as a novel inexpensive and minimally invasive method to screen risk patients for the outbreak of a disease even before the initial symptoms, to follow up treatment complications and disease relapse...
2014: Frontiers in Immunology
Kelly G Paulson, Andrew Tegeder, Christoph Willmes, Jayasri G Iyer, Olga K Afanasiev, David Schrama, Shinichi Koba, Renee Thibodeau, Kotaro Nagase, William T Simonson, Aaron Seo, David M Koelle, Margaret Madeleine, Shailender Bhatia, Hideki Nakajima, Shigetoshi Sano, James S Hardwick, Mary L Disis, Michele A Cleary, Jürgen C Becker, Paul Nghiem
Merkel cell carcinoma (MCC) is an aggressive, polyomavirus-associated skin cancer. Robust cellular immune responses are associated with excellent outcomes in patients with MCC, but these responses are typically absent. We determined the prevalence and reversibility of major histocompatibility complex class I (MHC-I) downregulation in MCC, a potentially reversible immune-evasion mechanism. Cell-surface MHC-I expression was assessed on five MCC cell lines using flow cytometry as well as immunohistochemistry on tissue microarrays representing 114 patients...
November 2014: Cancer Immunology Research
A Willms, S Schaaf, C Güsgen, S Waldeck, R Schwab
Abdominal actinomycosis is a rare, chronic and slowly progressive granulomatous disease. The clinical presentation of abdominal actinomycosis shows a great variability and it often mimics other intraabdominal pathologies like chronic inflammatory bowel diseases or malignancies. A correct diagnosis can rarely be established before radical surgery especially in patients with advanced tumors and an acute clinical presentation. Actinomyces are considered to be residential saprophytes in the gastroinstetinal tract and require a mucosal lesion to cause an opportunistic infection...
June 2014: Zeitschrift Für Gastroenterologie
Manfred Fischer, Willm U Kampen
The skeleton is a potential metastatic target of many malignant tumors. Up to 85% of prostate and breast cancer patients may develop bone metastases causing severe pain syndromes in many of them. In patients suffering from multilocular, mainly osteoblastic lesions and pain syndrome, radionuclide therapy is recommended for pain palliation. Low-energy beta-emitting radionuclides ((153)samarium-ethylenediaminetetrameth-ylenephosphonate (EDTMP) and (89)strontium) deliver high radiation doses to bone metastases and micrometastases in the bone marrow, but only negligible doses to the hematopoietic marrow...
April 2012: Breast Care
David C Willms, Ruben Mendez, Vanjah Norman, Joseph H Chammas
A 39-year-old man experienced total obstruction of a distal tracheal plastic stent by a tumor mass, preventing effective ventilation and resulting in cardiac arrest. Resuscitation by emergency bedside venoarterial extracorporeal membrane oxygenation (ECMO) permitted time to physically remove the obstructing tumor and reestablish successful ventilation and liberation from ventilatory support. We review several other reported cases of emergency ECMO to resuscitate patients with acute airway obstruction.
April 2012: Respiratory Care
Christoph Willmes, Christian Adam, Miriam Alb, Lena Völkert, Roland Houben, Jürgen C Becker, David Schrama
Merkel cell carcinoma (MCC) is a rare and highly aggressive skin cancer associated with the Merkel cell polyomavirus (MCV). As MCC cell lines show oncogene addiction to the MCV T antigens, pharmacologic interference of the large T antigen (LTA) may represent an effective therapeutic approach for this deadly cancer. In this study, we investigated the effects of IFNs on MCC cell lines, especially on MCV-positive (MCV(+)) lines. Type I IFNs (i.e., Multiferon, a mix of different IFN-α subtypes, and IFN-β) strongly inhibited the cellular viability...
April 15, 2012: Cancer Research
Michael Wenzel, Michael Wunderlich, Robert Besch, Hendrik Poeck, Simone Willms, Astrid Schwantes, Melanie Kremer, Gerd Sutter, Stefan Endres, Andreas Schmidt, Simon Rothenfusser
A key host response to limit microbial spread is the induction of cell death when foreign nucleic acids are sensed within infected cells. In mouse macrophages, transfected DNA or infection with modified vaccinia virus Ankara (MVA) can trigger cell death via the absent in melanoma 2 (AIM2) inflammasome. In this article, we show that nonmyeloid human cell types lacking a functional AIM2 inflammasome still die in response to cytosolic delivery of different DNAs or infection with MVA. This cell death induced by foreign DNA is independent of caspase-8 and carries features of mitochondrial apoptosis: dependence on BAX, APAF-1, and caspase-9...
January 1, 2012: Journal of Immunology: Official Journal of the American Association of Immunologists
Frank R Datema, Ana Moya, Peter Krause, Thomas Bäck, Lars Willmes, Ton Langeveld, Robert J Baatenburg de Jong, Henk M Blom
BACKGROUND: Electronic patient files generate an enormous amount of medical data. These data can be used for research, such as prognostic modeling. Automatization of statistical prognostication processes allows automatic updating of models when new data is gathered. The increase of power behind an automated prognostic model makes its predictive capability more reliable. Cox proportional hazard regression is most frequently used in prognostication. Automatization of a Cox model is possible, but we expect the updating process to be time-consuming...
January 2012: Head & Neck
Marcus H T Reinges, Timo Krings, Veit Rohde, Franz-Josef Hans, Klaus Willmes, Armin Thron, Joachim M Gilsbach
The effect of newly acquired central pareses on functional MRI (fMRI) signal pattern is not known, since up to now all investigated patients were examined while they already experienced the motor weakness. We describe the first prospective and controlled study demonstrating the impact of new, acquired central pareses on fMRI motor activation pattern. Six patients suffering from a new central paresis after resection of a brain tumor infiltrating the central region were prospectively compared with a control group of five patients without postoperative paresis and a group of six healthy, age-matched controls who were investigated at two time points...
February 15, 2005: NeuroImage
B Pozo Mengual, I Pérez Bustamante, E Fernández Fernández, R Mialdea Fernández, G Briones Mardones, M García-Cosio Piqueras, A Escudero Barrilero
We report a case of benign retroperitoneal schwannoma diagnosed casual in a 23 years old woman treated of a Wilm's tumour twenty years ago. A review of the on this unusual tumour is included.
May 2003: Actas Urologicas Españolas
Canan Akyüz, Kudret CaClar, Suna Emir, Münevver Büyükpamukçu
Veno-occlusive disease (VOD) is a rare complication of chemotherapy in children with cancer. In the literature successful treatment of severe VOD has not been well determined. The authors report a 5-year-old boy with Willms tumor whose condition was complicated with VOD while receiving chemotherapy. He was treated successfully with high-dose methylprednisolone. After therapy, the clinical signs of VOD, such as abdominal ascites, oliguria, and jaundice, disappeared without any adverse effects of therapy.
June 2003: Pediatric Hematology and Oncology
T Krings, R Töpper, K Willmes, M H T Reinges, J M Gilsbach, A Thron
OBJECTIVE: To demonstrate whether cortical activation within different cortical motor regions in neurosurgical patients varies with the degree of paresis induced by mass lesions near the central region. METHODS: A total of 110 patients with brain tumors infiltrating the central region and with varying degrees of paresis were investigated employing fMRI during the performance of hand motor tasks. The percent signal change between rest and activation was calculated for four cortical regions: primary motor cortex (M1), supplementary motor area, premotor area, and superior parietal lobule...
February 12, 2002: Neurology
M Roux, E Hervet, P Delavierre, M Audry
No abstract text is available yet for this article.
June 14, 1973: La Semaine des Hôpitaux: Organe Fondé Par L'Association D'enseignement Médical des Hôpitaux de Paris
H Frerichs, B Willms, W Creutzfeldt
No abstract text is available yet for this article.
March 1969: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
D Hans, C Bressac, R Amalric, F Santamaria, H Brandone, Y Ayme, P M Martin, J Jacquemier, J C Pietra, C Willm
Prognosis was analyzed as a function of histologic grade, axillary gland spread and hormonal receptors in a consecutive series of 1000 patients with breast cancer (stages I and II) treated by conservative tumorectomy and axillary curettage, combined with radiotherapy, and followed up for between 3 and 12 years. The three factors analyzed are of major importance in that they constituted a veritable tumoral identity card. Grade I tumors, the absence of glandular spread and the presence of hormonal receptors are correlated with cancer of good prognosis, whereas grade III tumors, major axillary spread and absence of hormonal receptors are related to a poor prognosis...
November 1987: Journal de Chirurgie
M Rosenfeld, B M Rodgers, J L Talbert
Acute abdominal pain is the presenting manifestation in approximately 30% of all patients with Willms' tumor. In a small proportion of these patients this pain is significant enough to engender a diagnosis of an acute surgical abdomen. Six of 38 patients with Wilms' tumors treated between the years 1965 and 1975 at the Shands Teaching Hospital of the University of Florida Medical Center have had significant pain. Our experience with these patients emphasizes the importance of thoroughly palpating the abdomen of any child with a suspected acute surgical condition, following induction of anesthesia and prior to initiating the operation...
September 1977: Archives of Surgery
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