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R Welte, P Eller, I Lorenz, M Joannidis, R Bellmann
Anidulafungin concentrations were quantified with high pressure liquid chromatography (HPLC) and UV detection in ascites and in pleural effusion of ten adult critically ill patients. Samples were collected from ascites and from pleural drains or during paracentesis and thoracentesis, respectively. Anidulafungin levels in ascites (0.12-0.99 μg/ml) and in pleural effusion (0.32-2.02 μg/ml) were below the simultaneous plasma levels (1.04-7.70 and 2.48-13.36 μg/ml, respectively) and below the MIC values of several pathogenic Candida strains...
February 12, 2018: Antimicrobial Agents and Chemotherapy
Sabine Zenz, Julia K Mader, Werner Regittnig, Martina Brunner, Stefan Korsatko, Beate Boulgaropoulos, Christoph Magnes, Reingard Raml, Sophie H Narath, Philipp Eller, Thomas Augustin, Thomas R Pieber
Context: Complete loss of beta-cell function in type 1 diabetes (T1DM) patients may lead to an increased risk of severe hypoglycaemia. Objective: We aimed to determine the impact of C-peptide status on glucagon response and endogenous glucose production (EGP) during hypoglycaemia in T1DM patients. Design/ Setting: We conducted an open, comparative trial. Patients: 10 C-peptide positive (C-pos) and 11 matched C-peptide negative (C-neg) T1DM patients were enrolled...
February 1, 2018: Journal of Clinical Endocrinology and Metabolism
Janet Prvu Bettger, Vu Q C Nguyen, J George Thomas, Tami Guerrier, Qing Yang, Mark A Hirsch, Terrence Pugh, Gabrielle Harris, Mary Ann Eller, Carol Pereira, Deanna Hamm, Eric A Rinehardt, Matthew Shall, Janet P Niemeier
Attention to healthcare quality and safety has increased dramatically. The focus internally within an organization is not without influence from external policy and research findings. Compared with other specialties, efforts to align and advance rehabilitation research, practice and policy using electronic health record data are in the early stages. In this special communication we define quality, apply the dimensions of quality to rehabilitation, and illustrate the feasibility and utility of electronic health record data for research on rehabilitation care quality and outcomes...
January 30, 2018: Archives of Physical Medicine and Rehabilitation
Sherily Pereira-Morales, Carmen Mabel Arroyo-Novoa, Annete Wysocki, Lucille Sanzero Eller
CONTEXT: Acute postoperative pain remains inadequately assessed and managed. A valid instrument that assesses acute pain in sedated Post-Anesthesia Care Unit (PACU) patients is needed. OBJECTIVES: Two behavioral pain assessment instruments, the Non-Verbal Pain Scale Revised (NVPS-R) and Critical Care Pain Observation Tool (CPOT), were used to determine if these instruments adequately assess acute pain in the PACU. METHODS: A crossover study design was used...
February 5, 2018: Clinical Journal of Pain
A S Senders, A Ruiz Oropeza, B Kristensen, E Eller, H F Kjaer, C Bindslev-Jensen, C G Mortz
No abstract text is available yet for this article.
January 31, 2018: Journal of Allergy and Clinical Immunology in Practice
Mara Rose de Oliveira, Thaís Jordânia Silva, Edvaldo Barros, Valéria Monteze Guimarães, Maria Cristina Baracat-Pereira, Monique Renon Eller, Jane Sélia Dos Reis Coimbra, Eduardo Basílio de Oliveira
This review is focused on the state-of-art of peptides with inhibitory activity towards angiotensin I-converting enzyme (ACE) - thus, with anti-hypertensive potential - derived from enzymatic hydrolysis of caseins. Firstly, molecular characteristics of caseins relevant to a better understanding of this subject were concisely commented. Next, a brief description of the pathophysiology of hypertension was explained, focusing on the ACE role in regulation of blood pressure in human body. Then, casein-derived peptides with ACE inhibitory capacity were specifically addressed...
January 25, 2018: Applied Biochemistry and Biotechnology
Cristina Eller-Vainicher, Serena Palmieri, Elisa Cairoli, Giovanni Goggi, Alfredo Scillitani, Maura Arosio, Alberto Falchetti, Iacopo Chiodini
OBJECTIVES: To determine the effect of denosumab, which is used in primary osteoporosis (PO), in primary hyperparathyroidism (PHPT)-related osteoporosis. DESIGN: Retrospective, longitudinal study. SETTING: Outpatient osteoporosis clinic. PARTICIPANTS: Older women with PHPT (78.6 ± 5.5) (n = 25) and PO (78.8 ± 5.2) (n = 25) matched on age, body mass index, familial history of hip fracture, femoral bone mineral density (BMD), and personal history of fragility fractures...
January 24, 2018: Journal of the American Geriatrics Society
Barbieri Anna Maria, Chiodini Iacopo, Ragni Enrico, Colaianni Graziana, Gadda Franco, Locatelli Marco, Lampertico Pietro, Spada Anna Maria, Eller-Vainicher Cristina
Tenofovir disoproxil fumarate (TDF) is an antiretroviral drug commonly used for the management of Human Immunodeficiency Virus (HIV) in highly active antiretroviral therapy (HAART) and of chronic Hepatitis B Virus (HBV) infections. Long-term TDF-treated subjects present decrease of bone mineral density and rarely severe osteomalacia. Although these adverse effects have been attributed to the impaired proximal tubule function, a possible direct involvement of TDF on osteoblasts should be taken into account. The aim of this study was to evaluate whether sodium phosphate transporters NPT2A (sodium-dependent phosphate transport protein 2A), NPT2C (sodium-dependent phosphate transport protein 2C), PIT1 (sodium-dependent phosphate transporter 1) and PIT2 (sodium-dependent phosphate transporter 2) were expressed in primary human osteoblasts (HOBs), whether their expression was related to HOBs differentiation and whether TDF could affect mineralization and gene expression...
January 24, 2018: Journal of Cellular Biochemistry
E Cairoli, S Palmieri, G Goggi, L Roggero, M Arosio, I Chiodini, C Eller-Vainicher
PURPOSE: To compare the response to denosumab (DMAb) therapy with that of oral bisphosphonate (BISPH) treatment in postmenopausal women with primary osteoporosis (PO). METHODS: In this retrospective study, we compared data of 75 PO female patients treated for 24 months with DMab (DMAb Group, age 72.6 ± 8.9 years) with those of 75 PO patients treated with oral bisphosphonates (BISPH Group), matched for age, body mass index, femoral bone mineral density (BMD), prevalent fragility fractures and familiar history of hip fracture...
January 16, 2018: Journal of Endocrinological Investigation
J Bousquet, S Arnavielhe, A Bedbrook, G Alexis-Alexandre, M van Eerd, R Murray, G W Canonica, M Illario, E Menditto, G Passalacqua, C Stellato, M Triggiani, P Carreiro-Martins, J Fonseca, M Morais Almeida, L Nogueira-Silva, A M Pereira, A Todo Bom, I Bosse, D Caimmi, P Demoly, P Devillier, J F Fontaine, J Just, G L Onorato, M L Kowalski, P Kuna, B Samolinski, J M Anto, J Mullol, A Valero, P V Tomazic, K C Bergmann, T Keil, L Klimek, R Mösgues, S Shamai, T Zuberbier, E Murphy, Peter McDowall, D Price, D Ryan, A Sheikh, N H Chavannes, W J Fokkens, V Kvedariene, A Valiulis, C Bachert, P W Hellings, I Kull, E Melén, M Wickman, C Bindslev-Jensen, E Eller, T Haahtela, E Valovirta, N G Papadopoulos, I Annesi-Maesano, M Bewick, S Bosnic-Anticevich, A A Cruz, G De Vries, B Gemicioglu, D Larenas-Linnemann, D Laune, E Mathieu-Dupas, R E O'Hehir, F Portejoie, V Siroux, O Spranger, O VandenPlas, A Yorgancioglu
BACKGROUND: Large observational implementation studies are needed to triangulate the findings from randomized control trials (RCTs) as they reflect "real world" everyday practice. In a pilot study, we attempted to provide additional and complementary insights on the real life treatment of allergic rhinitis using mobile technology. METHODS: A mobile phone app (Allergy Diary, freely available Google Play and Apple App stores) collects the data of daily visual analogue scales (VAS) for (i) overall allergic symptoms, (ii) nasal, ocular and asthma symptoms, (iii) work, as well as (iv) medication use using a treatment scroll list including all medications (prescribed and over the counter (OTC)) for rhinitis customized for 15 countries...
January 15, 2018: Allergy
Antonella Muraro, Montserrat Fernandez-Rivas, Kirsten Beyer, Victòria Cardona, Andrew Clark, Esben Eller, Jonathan O'B Hourihane, Marek Jutel, Aziz Sheikh, Ioana Agache, Katrina J Allen, Liz Angier, Barbara Ballmer-Weber, Maria Beatrice Bilò, Carsten Bindslev-Jensen, Carlos A Camargo, Antonella Cianferoni, Audrey DunnGalvin, Philippe A Eigenmann, Susanne Halken, Karin Hoffmann-Sommergruber, Susanne Lau, Caroline Nilsson, Lars K Poulsen, Franziska Rueff, Jonathan Spergel, Gunter Sturm, Frans Timmermans, Maria J Torres, Paul Turner, Ronald van Ree, Magnus Wickman, Margitta Worm, E N Clare Mills, Graham Roberts
The accurate assessment and communication of the severity of acute allergic reactions is important to patients, clinicians, researchers, the food industry, public health and regulatory authorities. Severity has different meanings to different stakeholders with patients and clinicians rating the significance of particular symptoms very differently. Many severity scoring systems have been generated, most focusing on the severity of reactions following exposure to a limited group of allergens. They are heterogeneous in format, none has used an accepted developmental approach and none has been validated...
January 13, 2018: Allergy
Thomas Houmann Petersen, Charlotte Gotthard Mortz, Carsten Bindslev-Jensen, Esben Eller
BACKGROUND: Cow's milk allergy (CMA) affects 2% of all children. This study investigatescomponent-resolved diagnostics(CRD) to cow's milk proteins in children suspected of CMA, by correlating the level of CRD with outcome of the oral challenge. Furthermore, we evaluate the ability of serial CRD measurements to distinguish children with persistent CMA from children developing tolerance. METHODS: We included data from 78 children referred to the Allergy Centre during a 13-year period...
January 4, 2018: Pediatric Allergy and Immunology
Margret Leineweber, Katrin Spekker-Bosker, Vanessa Ince, Gereon Schares, Andrew Hemphill, Silvia K Eller, Walter Däubener
The obligate intracellular apicomplexan parasite Neospora caninum (N. caninum) is closely related to Toxoplasma gondii (T. gondii). The dense granules, which are present in all apicomplexan parasites, are important secretory organelles. Dense granule (GRA) proteins are released into the parasitophorous vacuole (PV) following host cell invasion and are known to play important roles in the maintenance of the host-parasite relationship and in the acquisition of nutrients. Here, we provide a detailed characterization of the N...
2017: BioMed Research International
Franziska Eller, Hana Skálová, Joshua S Caplan, Ganesh P Bhattarai, Melissa K Burger, James T Cronin, Wen-Yong Guo, Xiao Guo, Eric L G Hazelton, Karin M Kettenring, Carla Lambertini, Melissa K McCormick, Laura A Meyerson, Thomas J Mozdzer, Petr Pyšek, Brian K Sorrell, Dennis F Whigham, Hans Brix
Phragmites australis is a cosmopolitan grass and often the dominant species in the ecosystems it inhabits. Due to high intraspecific diversity and phenotypic plasticity, P. australis has an extensive ecological amplitude and a great capacity to acclimate to adverse environmental conditions; it can therefore offer valuable insights into plant responses to global change. Here we review the ecology and ecophysiology of prominent P. australis lineages and their responses to multiple forms of global change. Key findings of our review are that: (1) P...
2017: Frontiers in Plant Science
Teri G Lindgren, Darcel Reyes, Lucille Eller, Dean Wantland, Carmen Portillo, William L Holzemer, Ellah Matshediso, Inge Corless, Jeanne Kemppainen, K Dintle Mogobe, Allison Webel, Kathleen Nokes, Patrice Nicholas, Marta Rivero Mendez, Paula Reid, Solymar Solis Baez, Mallory O Johnson, Yvette Cuca, Carol Dawson Rose
Health literacy, including people's abilities to access, process, and comprehend health-related information, has become an important component in the management of complex and chronic diseases such as HIV infection. Clinical measures of health literacy that focus on patients' abilities to follow plans of care ignore the multidimensionality of health literacy. Our thematic analysis of 28 focus groups from a qualitative, multisite, multinational study exploring information practices of people living with HIV (PLWH) demonstrated the importance of location as a dimension of health literacy...
November 8, 2017: Journal of the Association of Nurses in AIDS Care: JANAC
Maura P Alves, Rafael L Salgado, Monique R Eller, Roberto Sousa Dias, Sérgio Oliveira de Paula, Antonio Fernandes de Carvalho
This work evaluated the expression and activity of a metalloprotease released by Pseudomonas fluorescens 07A in milk. Low relative expression of the protease by the strain was observed after incubation for 12 h at 25°C while the strain was in the logarithmic growth phase. After 24 h, protease production significantly increased (P < 0.05) and remained constant for up to 48 h, a time range during which the strain remained in the stationary phase. Conversely, at refrigeration temperatures, at 12 h the strain was still in the lag phase and expressed the protease at higher levels than when the logarithmic phase was reached...
December 13, 2017: Journal of Dairy Science
Oscar Franken, Milou Huizinga, Jacintha Ellers, Matty P Berg
Temperature extremes are predicted to increase in frequency, intensity and duration under global warming and are believed to significantly affect community composition and functioning. However, the effect of extreme climatic events on communities remains difficult to predict, especially because species can show dissimilar responses to abiotic changes, which may affect the outcome of species interactions. To anticipate community responses we need knowledge on within and among species variation in stress tolerance...
December 9, 2017: Oecologia
Elias Atallah, Hassan Saad, Kimon Bekelis, Nohra Chalouhi, Stavropoula Tjoumakaris, David Hasan, Jorge Eller, David Stidd, Robert H Rosenwasser, Pascal Jabbour
OBJECTIVE Thromboembolic complications continue to be encountered with Pipeline embolization devices (PEDs) despite routine clopidogrel/aspirin antiplatelet therapy. This study examined the safety and efficacy of prasugrel in the management of clopidogrel-resistant patients treated for cerebral aneurysms. METHODS Four hundred thirty-seven consecutive patients were identified between January 2011 and May 2016. Patients allergic, or having less than 30% platelet inhibition, to a daily 75-mg dose of clopidogrel received 10 mg of prasugrel daily (n = 20) or 90 mg of ticagrelor twice daily (n = 2)...
December 8, 2017: Journal of Neurosurgery
Cleiton B Eller, Fernanda de V Barros, Paulo R L Bittencourt, Lucy Rowland, Maurizio Mencuccini, Rafael S Oliveira
Faster growth in tropical trees is usually associated with higher mortality rates, but the mechanisms underlying this relationship are poorly understood. In this study, we investigate how tree growth patterns are linked with environmental conditions and hydraulic traits, by monitoring the cambial growth of nine tropical cloud forest tree species coupled with numerical simulations using a optimization model. We find that fast-growing trees have lower xylem safety margins than slow-growing trees and this pattern is not necessarily linked to differences in stomatal behaviour or environmental conditions when growth occurs...
December 6, 2017: Plant, Cell & Environment
Wouter Halfwerk, Judith A H Smit, Hugo Loning, Amanda M Lea, Inga Geipel, Jacintha Ellers, Michael J Ryan
Animals choosing particular display sites often balance sexual and natural selection pressures. Here we assess how physical properties of display sites can alter this balance by influencing signal production and attractiveness of the túngara frog (Physalaemus pustulosus). Males that call from very shallow water bodies (few mm depth) benefit from reduced predation risk, but by manipulating water levels, we show that this comes at a cost of reduced attractiveness to females. Our data show that calling from shallower water reduces a male's ability to float, limits the inflation of his vocal sac, and consequently reduces signal conspicuousness in terms of amplitude and complexity...
December 1, 2017: Nature Communications
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