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https://www.readbyqxmd.com/read/29662622/quantitative-parameters-in-dynamic-contrast-enhanced-magnetic-resonance-imaging-for-the-detection-and-characterization-of-prostate-cancer
#1
Cheng Wei, Bowen Jin, Magdalena Szewczyk-Bieda, Stephen Gandy, Stephen Lang, Yilong Zhang, Zhihong Huang, Ghulam Nabi
Objectives: to assess the diagnostic accuracy of quantitative parameters of DCE-MRI in multi-parametric MRI (mpMRI) in comparison to the histopathology (including Gleason grade) of prostate cancer. Patients and methods: 150 men with suspected prostate cancer (abnormal digital rectum examination and or elevated prostate-specific antigen) received pre-biopsy 3T mpMRI and were recruited into peer-reviewed, protocol-based prospective study. The DCE-MRI quantitative parameters ( Ktrans (influx transfer constant) and kep (efflux rate constant)) of the cancerous and normal areas were recorded using four different kinetic models employing Olea Sphere (Olea Medical, La Ciotat, France)...
March 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29661160/characterizing-the-experience-of-agitation-in-patients-with-bipolar-disorder-and-schizophrenia
#2
Jenna Roberts, Alfredo Gracia Canales, Sophee Blanthorn-Hazell, Anca Craciun Boldeanu, Davneet Judge
BACKGROUND: Agitation is a common manifestation of bipolar disorder and schizophrenia which includes symptoms ranging from inner tension and unease to violence and aggression. Much of the existing literature has focused on agitation in the acute setting, with the patient experience poorly defined. Thus, the aim of this study was to characterize agitation and its management from a patient perspective, with the focus on those who reside in the community. METHODS: Surveys were completed across Germany, Spain and the UK by 583 community dwelling patients with schizophrenia or bipolar disorder who experienced episodes of agitation...
April 16, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29660933/medical-comorbidity-in-alzheimer-s-disease-a-nested-case-control-study
#3
Jen-Hung Wang, Ya-Ju Wu, Boon Lead Tee, Raymond Y Lo
BACKGROUND: Little is known about the distribution of medical comorbidities in Alzheimer's disease (AD). OBJECTIVE: We aimed to describe the comorbidity pattern of AD in a nested case-control study. METHODS: Incident AD cases were identified by International Classification of Diseases codes in a random sample of 2 million individuals in Taiwan National Health Insurance program during 2001-2011. We further restricted cases to those treated with AD drugs of approved reimbursement...
April 11, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29658792/scandium-and-terbium-radionuclides-for-radiotheranostics-current-state-of-development-towards-clinical-application
#4
Cristina Müeller, Katharina A Domnanich, Christoph A Umbricht, Nicholas P van der Meulen
Currently, different radiometals are in use for imaging and therapy in nuclear medicine: 68 Ga and 111 In are examples of nuclides for positron emission tomography (PET) and single photon emission computed tomography (SPECT), respectively, while 177 Lu and 225 Ac are used for β- - and α-radionuclide therapy. The application of diagnostic and therapeutic radionuclides of the same element (radioisotopes) would utilize chemically-identical radiopharmaceuticals for imaging and subsequent treatment, thereby enabling the radiotheranostic concept...
April 16, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29644946/the-incidence-risk-factors-and-chronobiology-of-acute-myocardial-infarction-ten-years-after-hurricane-katrina
#5
John C Moscona, Matthew N Peters, Rohit Maini, Paul Katigbak, Bradley Deere, Holly Gonzales, Christopher Westley, Hassan Baydoun, Kapil Yadav, Patrick Ters, Ahmad Jabbar, Alaa Boulad, Indrajeet Mahata, Taraka V Gadiraju, Ryan Nelson, Sudesh Srivastav, Anand Irimpen
OBJECTIVE: The purpose of this study was to investigate the 10-year impact of Hurricane Katrina on the incidence of acute myocardial infarction (AMI) along with contributing risk factors and any alteration in chronobiology of AMI. METHODS: A single-center, retrospective, comparison study of AMI incidence was performed at Tulane University Health Sciences Center from 2 years before Hurricane Katrina to 10 years after Hurricane Katrina. A 6-year, pre-Katrina and 10-year, post-Katrina cohort were also compared according to pre-specified demographic, clinical, and chronobiological data...
April 12, 2018: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/29630013/intrauterine-device-insertion-before-and-after-mandated-health-care-coverage-the-importance-of-baseline-costs
#6
Erica Heisel, Giselle E Kolenic, Michelle M Moniz, Emily K Kobernik, Leah Minadeo, Neil S Kamdar, Vanessa K Dalton
OBJECTIVE: To evaluate changes in out-of-pocket cost for intrauterine device (IUD) placement before and after mandated coverage of contraceptive services and to examine how changes in out-of-pocket cost influence IUD insertion as a function of baseline cost. METHODS: We conducted a cross-sectional pre-post analysis at the plan level using a large deidentified medical claims database to analyze our primary outcome, new IUD insertions among women enrolled in employer-sponsored health plans in 2009 and 2014, and our secondary outcome, out-of-pocket cost...
April 6, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29605344/development-and-validation-of-a-quality-of-life-instrument-for-patients-with-laryngeal-cleft
#7
Alexandria L Irace, Ryan D Walker, Kosuke Kawai, Meaghan Maddock, Natasha D Dombrowski, Georgios Sideridis, Lynne Ferrari, Reza Rahbar
OBJECTIVE: To develop and validate a novel pediatric health-related quality of life (HR-QoL) instrument for patients with laryngeal cleft and their families. METHODS: We surveyed primary caregivers of patients that underwent endoscopic repair of Type I or II laryngeal cleft. The proposed HR-QoL instrument consists of 40 items representing four domains, assessing the patient's physical symptoms, the patient's and family's social functioning, and the family's emotions regarding the patient's illness pre- and post-operatively...
May 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29603900/men-who-have-sex-with-men-more-often-chose-daily-than-event-driven-use-of-pre-exposure-prophylaxis-baseline-analysis-of-a-demonstration-study-in-amsterdam
#8
Elske Hoornenborg, Roel Ca Achterbergh, Maarten F Schim van der Loeff, Udi Davidovich, Jannie J van der Helm, Arjan Hogewoning, Yvonne Thp van Duijnhoven, Gerard Jb Sonder, Henry Jc de Vries, Maria Prins
INTRODUCTION: The Amsterdam PrEP project is a prospective, open-label demonstration study at a large sexually transmitted infection (STI) clinic. We examined the uptake of PrEP; the baseline characteristics of men who have sex with men (MSM) and transgender persons initiating PrEP; their choices of daily versus event-driven PrEP and the determinants of these choices. METHODS: From August 2015 through May 2016, enrolment took place at the STI clinic of the Public Health Service of Amsterdam, the Netherlands...
March 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29582748/airway-management-changes-associated-with-rising-radiologic-incidence-of-external-laryngotracheal-injury
#9
Derrick R Randall, Luke Rudmik, Chad G Ball, J Douglas Bosch
BACKGROUND: Traumatic laryngeal injuries are uncommon life-threatening injuries that require prompt, rational management of a potentially precarious airway. It is unclear whether the current incidence of laryngotracheal injury is due to enhanced injury detection or increased occurrence. The objective of this study was to evaluate the relations between diagnostic imaging with both initial airway management and surgical treatment in patients with external laryngotracheal injuries (ELTIs) in Alberta...
April 2018: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/29579074/prevalence-and-determinants-of-self-medication-practice-among-selected-households-in-addis-ababa-community
#10
Mensur Shafie, Mebrahtu Eyasu, Kedija Muzeyin, Yoseph Worku, Sagrario Martín-Aragón
BACKGROUND AND AIM: Self-medication (SM) is one part of self-care which is known to contribute to primary health care. If practiced appropriately, it has major benefits for the consumers such as self-reliance and decreased expense. However, inappropriate practice can have potential dangers such as incorrect self-diagnosis, dangerous drug-drug interactions, incorrect manner of administration, incorrect dosage, incorrect choice of therapy, masking of a severe disease, and/or risk of dependence and abuse...
2018: PloS One
https://www.readbyqxmd.com/read/29570736/medical-expenditure-and-unmet-need-of-the-pre-elderly-and-the-elderly-according-to-job-status-in-korea-are-the-elderly-indeed-most-vulnerable
#11
Hwa-Young Lee, Naoki Kondo, Juhwan Oh
Increase in the elderly population and early retirement imposes immense economic burden on societies. Previous studies on the association between medical expenditure and working status in the elderly population have not adequately addressed reverse causality problem. In addition, the pre-elderly group has hardly been discussed in this regard. This study assessed possible causal association between employment status and medical expenditure as well as employment status and medical unmet needs in a representative sample of the Korean elderly (aged≧65) and the pre-elderly (aged ≧50 and < 65) adults from the Korea Health Panel Data (KHP)...
2018: PloS One
https://www.readbyqxmd.com/read/29560809/mbrrace-in-simulation-an-evaluation-of-a-multi-disciplinary-simulation-training-for-medical-emergencies-in-obstetrics-memo
#12
Mary Lavelle, Jennifer Abthorpe, Thomas Simpson, Gabriel Reedy, Fiona Little, Anita Banerjee
The majority of maternal deaths in the UK are due to pre-existing or new-onset medical conditions, known as 'indirect deaths'. The MBRRACE report identified serious gaps in clinicians' human factors skills, including communication, leadership and teamwork, which contributed to maternal death. In response, we developed the first multi-disciplinary simulation-based training programme designed to address Medical Emergencies in Obstetrics (MEmO). Employing a mixed methods design, this study evaluated the educational impact of this training programme on the healthcare staff (n = 140), including the medical doctors (n = 91) and the midwives (n = 49)...
March 21, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29549460/success-rates-of-pre-hospital-difficult-airway-management-a-quality-control-study-evaluating-an-in-hospital-training-program
#13
Helmut Trimmel, Christoph Beywinkler, Sonja Hornung, Janett Kreutziger, Wolfgang G Voelckel
BACKGROUND: Competence in emergency airway management is key in order to improve patient safety and outcome. The scope of compulsory training for emergency physicians or paramedics is quite limited, especially in Austria. The purpose of this study was to review the difficult airway management performance of an emergency medical service (EMS) in a region that has implemented a more thorough training program than current regulations require, comprising 3 months of initial training and supervised emergency practice and 3 days/month of on-going in-hospital training as previously reported...
March 16, 2018: International Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29548604/effect-of-influenza-vaccine-on-tumor-necrosis-factor-like-weak-inducer-of-apoptosis-tweak-in-older-adults
#14
Maryam Keshtkar-Jahromi, Min Ouyang, Marzieh Keshtkarjahromi, Samah Almed, Huifen Li, Jeremy D Walston, Rebeca Rios, Sean X Leng
Influenza immunization is recommended for older adults annually, and has been reported to have cardiovascular protective effects. TNF-related weak inducer of apoptosis (TWEAK), an inflammatory mediator implicated in the development of cardiovascular diseases, could be a mechanism for such effect. The objective of this study was to evaluate the effect of influenza vaccine on TWEAK levels. Older persons over 70 years of age were recruited during 2007-2008 influenza season and immunized with the standard dose trivalent inactivated influenza vaccine...
March 13, 2018: Vaccine
https://www.readbyqxmd.com/read/29540886/use-of-internet-by-the-teaching-faculty-of-peshawar-medical-college-peshawar-khyber-pakhtunkhwa-pakistan
#15
Saeedullah Jan, Abid Hussain, Muhammad Ibrahim, Sarah Saeed
This study was planned to examine the hard and soft form of learning resources available on the internet accessed by the teaching faculty. This study was conducted at the Peshawar Medical College, Peshawar, Pakistan from January 2to April 2017. As the target population was not too large, no sampling technique was employed and census-based approach was adopted. For data collection, the pre-tested questionnaire was distributed among 115 faculty members of both basic and clinical sciences groups with a response rate of 66(57...
March 2018: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/29535259/high-frequency-airway-oscillating-device-for-respiratory-muscle-training-in-subjects-with-copd
#16
Enya Daynes, Neil J Greening, Theresa C Harvey-Dunstan, Sally J Singh
BACKGROUND: COPD is characterized by expiratory flow limitation, which results in symptomatic dyspnea and reduced exercise capacity. Changes in breathing mechanics mean the respiratory muscles are unable to respond to the ventilatory demands, increasing the sensation of dyspnea. A high-frequency oscillating device has been developed to improve dyspnea in patients with COPD. We conducted a feasibility trial to gain insight into the potential for recruitment, retention, and study design for a future randomized controlled trial...
March 13, 2018: Respiratory Care
https://www.readbyqxmd.com/read/29531048/the-great-recession-worsened-blood-pressure-and-blood-glucose-levels-in-american-adults
#17
Teresa Seeman, Duncan Thomas, Sharon Stein Merkin, Kari Moore, Karol Watson, Arun Karlamangla
Longitudinal, individual-specific data from the Multi-Ethnic Study of Atherosclerosis (MESA) provide support for the hypothesis that the 2008 to 2010 Great Recession (GR) negatively impacted the health of US adults. Results further advance understanding of the relationship by ( i ) illuminating hypothesized greater negative impacts in population subgroups exposed to more severe impacts of the GR and ( ii ) explicitly controlling for confounding by individual differences in age-related changes in health over time...
March 27, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29509763/clinical-and-cost-effectiveness-of-non-medical-prescribing-a-systematic-review-of-randomised-controlled-trials
#18
Timothy Noblet, John Marriott, Emma Graham-Clarke, Debra Shirley, Alison Rushton
OBJECTIVE: To evaluate the clinical and cost-effectiveness of non-medical prescribing (NMP). DESIGN: Systematic review. Two reviewers independently completed searches, eligibility assessment and assessment of risk of bias. DATA SOURCES: Pre-defined search terms/combinations were utilised to search electronic databases. In addition, hand searches of reference lists, key journals and grey literature were employed alongside consultation with authors/experts...
2018: PloS One
https://www.readbyqxmd.com/read/29506682/obtaining-a-follow-up-appointment-before-discharge-protects-against-readmission-for-patients-with-acute-coronary-syndrome-and-heart-failure-a-quality-improvement-project
#19
Vidagay Baky, Dane Moran, Tessa Warwick, Alice George, Tammy Williams, Eric McWilliams, Joseph E Marine
BACKGROUND: Cardiac patients have a high risk of readmission following hospital discharge. The aim of our project was to examine the factors associated with increased readmission rate, with a view to eventually decrease the rate of readmission for patients admitted to the hospital due to acute coronary syndrome (ACS) or heart failure. METHODS: Patients admitted to the cardiac step-down unit at a single private hospital from 2015 to 2016 were included in our study...
April 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29501249/laboratory-animal-allergy-reduction-from-2001-to-2016-an-intervention-study
#20
Francesca Larese Filon, Anna Drusian, Marcella Mauro, Corrado Negro
Exposure to laboratory animals (LA) can cause allergic sensitization and symptoms as rhinitis, conjunctivitis, asthma, anaphylaxis and dermatitis. In 2000, a program was instituted at Trieste Universities to decrease LA allergy among scientists and technicians working with animals. The aim of our study was to investigate LA allergy in workers exposed to LA from 2001 to 2016, and to verify the effects of a preventive program. Four hundred sixty seven people underwent pre-employment screening for a job with laboratory animals at Universities of Trieste consisting in a medical examination, a full respiratory and allergy anamnesis, using a standardized questionnaire, skin prick test with common and occupational allergens, and spirometry...
March 2018: Respiratory Medicine
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