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Brian smith

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https://www.readbyqxmd.com/read/28646704/location-and-characterization-of-lignin-in-tracheid-cell-walls-of-radiata-pine-pinus-radiata-d-don-compression-woods
#1
Miao Zhang, Catherine Lapierre, Noor Liyana Nouxman, Michel K Nieuwoudt, Bronwen G Smith, Ramesh R Chavan, Brian H McArdle, Philip J Harris
Tilted stems of softwoods form compression wood (CW) and opposite wood (OW) on their lower and upper sides, respectively. More is known about the most severe form of CW, severe CW (SCW), but mild CWs (MCWs) also occur widely. Two grades of MCWs, MCW1 and MCW2, as well as SCW and OW were identified in the stems of radiata pine (Pinus radiata) that had been slightly tilted. The four wood types were identified by the distribution of lignin in the tracheid walls determined by fluorescence microscopy. A solution of the fluorescent dye acridine orange (AO) (0...
June 15, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28637922/targeting-factor-d-of-the-alternative-complement-pathway-reduces-geographic-atrophy-progression-secondary-to-age-related-macular-degeneration
#2
Brian L Yaspan, David F Williams, Frank G Holz, Carl D Regillo, Zhengrong Li, Amy Dressen, Menno van Lookeren Campagne, Kha N Le, Robert R Graham, Tatiana Beres, Tushar R Bhangale, Lee A Honigberg, Ashley Smith, Erin C Henry, Carole Ho, Erich C Strauss
Geographic atrophy is an advanced form of age-related macular degeneration (AMD) and a leading cause of vision loss for which there are no approved treatments. Genetic studies in AMD patients have implicated dysregulation of the alternative complement pathway in the pathogenesis of geographic atrophy. Lampalizumab is a potential therapeutic that targets complement factor D, a pivotal activator of the alternative complement pathway. The MAHALO phase 2 clinical trial was a multicenter, randomized, controlled study that evaluated lampalizumab administered by intravitreal injection monthly (n = 42) and every other month (n = 41) versus sham control (n = 40) in patients with geographic atrophy secondary to AMD...
June 21, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28636072/using-chief-complaint-in-addition-to-diagnosis-codes-to-identify-falls-in-the-emergency-department
#3
Brian W Patterson, Maureen A Smith, Michael D Repplinger, Michael S Pulia, James E Svenson, Michael K Kim, Manish N Shah
OBJECTIVES: To compare incidence of falls in an emergency department (ED) cohort using a traditional International Classification of Diseases, Ninth Revision (ICD-9) code-based scheme and an expanded definition that included chief complaint information and to examine the clinical characteristics of visits "missed" in the ICD-9-based scheme. DESIGN: Retrospective electronic record review. SETTING: Academic medical center ED. PARTICIPANTS: Individuals aged 65 and older seen in the ED between January 1, 2013, and September 30, 2015...
June 21, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28634199/characterising-cis-regulatory-variation-in-the-transcriptome-of-histologically-normal-and-tumour-derived-pancreatic-tissues
#4
Mingfeng Zhang, Soren Lykke-Andersen, Bin Zhu, Wenming Xiao, Jason W Hoskins, Xijun Zhang, Lauren M Rost, Irene Collins, Martijn van de Bunt, Jinping Jia, Hemang Parikh, Tongwu Zhang, Lei Song, Ashley Jermusyk, Charles C Chung, Bin Zhu, Weiyin Zhou, Gail L Matters, Robert C Kurtz, Meredith Yeager, Torben Heick Jensen, Kevin M Brown, Halit Ongen, William R Bamlet, Bradley A Murray, Mark I McCarthy, Stephen J Chanock, Nilanjan Chatterjee, Brian M Wolpin, Jill P Smith, Sara H Olson, Gloria M Petersen, Jianxin Shi, Laufey Amundadottir
OBJECTIVE: To elucidate the genetic architecture of gene expression in pancreatic tissues. DESIGN: We performed expression quantitative trait locus (eQTL) analysis in histologically normal pancreatic tissue samples (n=95) using RNA sequencing and the corresponding 1000 genomes imputed germline genotypes. Data from pancreatic tumour-derived tissue samples (n=115) from The Cancer Genome Atlas were included for comparison. RESULTS: We identified 38 615 cis-eQTLs (in 484 genes) in histologically normal tissues and 39 713 cis-eQTL (in 237 genes) in tumour-derived tissues (false discovery rate <0...
June 20, 2017: Gut
https://www.readbyqxmd.com/read/28630741/the-reliability-of-commonly-used-arthroscopic-classifications-of-ligamentum-teres-pathology
#5
Brian M Devitt, Bjorn Smith, Robert Stapf, Suenghwan Jo, John M O'Donnell
The importance of the ligamentum teres (LT) in the hip is increasingly being recognized. However, the incidence of LT tears in the literature is extremely variable. Although classification systems exist their reliability in classifying LT pathology arthroscopically has not been well defined. To determine the inter- and intra-observer reliability of two existing classifications systems for the diagnosis of LT pathology at hip arthroscopy. Second, to identify key pathological findings currently not included. Four experienced hip-arthroscopists reviewed 40 standardized arthroscopic videos...
July 2017: Journal of Hip Preservation Surgery
https://www.readbyqxmd.com/read/28630717/arthroscopic-hip-preservation-surgery-practice-patterns-an-international-survey
#6
Kevin M Smith, Brayden J Gerrie, Patrick C McCulloch, Brian D Lewis, R Chad Mather, Geoffrey Van Thiel, Shane J Nho, Joshua D Harris
To design and conduct a survey analyzing pre-, intra- and post- hip arthroscopy practice patterns among hip arthroscopists worldwide. A 21-question, IRB-exempt, HIPAA-compliant, cross-sectional survey was conducted via email using SurveyMonkey to examine pre-operative evaluation, intra-operative techniques and post-operative management. The survey was administered internationally to 151 hip arthroscopists identified from publicly available sources. Seventy-five respondents completed the survey (151 ± 116 hip arthroscopy procedures per year; 8...
January 2017: Journal of Hip Preservation Surgery
https://www.readbyqxmd.com/read/28628811/evaluating-pedestrian-behavior-at-crosswalks-validation-of-a-pedestrian-behavior-questionnaire-for-the-u-s-population
#7
Shuchisnigdha Deb, Lesley Strawderman, Janice DuBien, Brian Smith, Daniel W Carruth, Teena M Garrison
The aim of this study was to develop and validate a self-reporting Pedestrian Behavior Questionnaire (PBQ) for the U.S. population to measure frequency of risky behaviors among pedestrians. The PBQ includes 50 survey items that allow respondents to rate the frequency with which they engage in different types of road-using behaviors as pedestrians. The validation study was conducted on 425 participants (228 males and 197 females) between the ages of 18 and 71. Confirmatory factor analysis differentiated pedestrian behaviors into five factor categories: violations, errors, lapses, aggressive behaviors, and positive behaviors...
June 16, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28625190/association-between-early-echocardiography-therapy-for-patent-ductus-arteriosus-and-outcomes-in-very-low-birth-weight-infants
#8
Jan Hau Lee, Rachel G Greenberg, Bin H Quek, Reese H Clark, Matthew M Laughon, P Brian Smith, Christoph P Hornik
BACKGROUND: In very low birth weight infants, persistence of a patent ductus arteriosus results in morbidity and mortality. Therapies to close the ductus are effective, but clinical outcomes may depend on the accuracy of diagnosis and the timing of administration. The objective of the present study was to characterise the association between early echocardiography, therapy for patent ductus arteriosus, and outcomes in very low birth weight infants. METHODS: This retrospective cohort study used electronic health record data on inborn infants of gestational age ⩽28 weeks and birth weight <1500 g who were discharged after day of life 7 from 362 neonatal ICU from 1997 to 2013...
June 19, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28619532/major-physical-health-conditions-and-risk-of-suicide
#9
Brian K Ahmedani, Edward L Peterson, Yong Hu, Rebecca C Rossom, Frances Lynch, Christine Y Lu, Beth E Waitzfelder, Ashli A Owen-Smith, Samuel Hubley, Deepak Prabhakar, L Keoki Williams, Nicole Zeld, Elizabeth Mutter, Arne Beck, Dennis Tolsma, Gregory E Simon
INTRODUCTION: Most individuals make healthcare visits before suicide, but many do not have a diagnosed mental health condition. This study seeks to investigate suicide risk among patients with a range of physical health conditions in a U.S. general population sample and whether risk persists after adjustment for mental health and substance use diagnoses. METHODS: This study included 2,674 individuals who died by suicide between 2000 and 2013 along with 267,400 controls matched on year and location in a case-control study conducted in 2016 across eight Mental Health Research Network healthcare systems...
June 7, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28617434/lispro-mitigates-%C3%AE-amyloid-and-associated-pathologies-in-alzheimer-s-mice
#10
Ahsan Habib, Darrell Sawmiller, Song Li, Yang Xiang, David Rongo, Jun Tian, Huayan Hou, Jin Zeng, Adam Smith, Shengnuo Fan, Brian Giunta, Takashi Mori, Glenn Currier, Douglas Ronald Shytle, Jun Tan
Lithium has been marketed in the United States of America since the 1970s as a treatment for bipolar disorder. More recently, studies have shown that lithium can improve cognitive decline associated with Alzheimer's disease (AD). However, the current United States Food and Drug Administration-approved lithium pharmaceutics (carbonate and citrate chemical forms) have a narrow therapeutic window and unstable pharmacokinetics that, without careful monitoring, can cause serious adverse effects. Here, we investigated the safety profile, pharmacokinetics, and therapeutic efficacy of LISPRO (ionic co-crystal of lithium salicylate and l-proline), lithium salicylate, and lithium carbonate (Li2CO3)...
June 15, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28612386/impact-of-comorbidities-on-outcomes-of-elderly-patients-with-diffuse-large-b-cell-lymphoma
#11
Caner Saygin, Xuefei Jia, Brian Hill, Robert Dean, Brad Pohlman, Mitchell R Smith, Deepa Jagadeesh
International prognostic index (IPI) has remained the primary prognostic tool in diffuse large B cell lymphoma (DLBCL) for more than 20 years. Even though the disease is more common in older population, the impact of comorbidities, dose reductions, and treatment-related adverse events (TAEs) on the outcome in elderly DLBCL patients has not been well established. We studied 413 consecutive patients aged ≥ 60 years who were treated at the Cleveland Clinic. The median age at diagnosis was 69 years, 58% of patients had high IPI score, and 85% had low Charlson comorbidity index (CCI)...
June 13, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28610934/boarding-icu-patients-are-our-rounding-practices-subpar
#12
Andrew M Nunn, Justin S Hatchimonji, Daniel N Holena, Mark J Seamon, Brian P Smith, Lewis J Kaplan, Niels D Martin, Patrick M Reilly, C William Schwab, Jose L Pascual
INTRODUCTION: Surgical Intensive Care Unit (SICU) patients "boarding" in ICUs other than the designated home unit have been shown to suffer increased rates of complications. We hypothesized that ICU rounding practices are different when SICU patients are housed in home vs. boarding ICUs. MATERIAL AND METHODS: SICU rounds were observed at an academic quaternary medical center. Individual patient rounding time and order seen on rounds along with patient data and demographics were recorded...
June 10, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28608680/correction-to-elucidating-proteoform-families-from-proteoform-intact-mass-and-lysine-count-measurements
#13
Michael R Shortreed, Brian L Frey, Mark Scalf, Rachel A Knoener, Anthony J Cesnik, Lloyd M Smith
No abstract text is available yet for this article.
June 13, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28608158/surface-water-mitigates-the-anti-metamorphic-effects-of-elevated-perchlorate-concentrations-in-new-mexico-spadefoot-toad-larvae-spea-multiplicata
#14
Melissa A Sandoz, Mike Wages, Kim J Wooten, Sheree L Clendening, Lucas R Smith, Brian Mulhearn, Philip N Smith
Perchlorate (ClO4(-)) has potential to negatively impact amphibian populations by inhibiting thyroid hormone production, and thus metamorphosis in developing larvae. However, variability exists in species sensitivity, and there is evidence suggesting that natural surface waters can mitigate the anti-metamorphic potential of perchlorate. New Mexico spadefoot toad tadpoles, Spea multiplicata, were exposed to natural surface waters spiked with nominal concentrations of 0, 1000, 1350, 1710, 3000, 5110, and 8000 μg/L perchlorate ion for up to 42 days...
June 12, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28601508/design-synthesis-and-biological-evaluation-of-renin-inhibitors-guided-by-simulated-annealing-of-chemical-potential-simulations
#15
Ian S Cloudsdale, John K Dickson, Thomas E Barta, Brian S Grella, Emilie D Smith, John L Kulp, Frank Guarnieri, John L Kulp
We have applied simulated annealing of chemical potential (SACP) to a diverse set of ∼150 very small molecules to provide insights into new interactions in the binding pocket of human renin, a historically difficult target for which to find low molecular weight (MW) inhibitors with good bioavailability. In one of its many uses in drug discovery, SACP provides an efficient, thermodynamically principled method of ranking chemotype replacements for scaffold hopping and manipulating physicochemical characteristics for drug development...
May 19, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28599198/hypoalbuminemia-systemic-inflammatory-response-syndrome-and-functional-outcome-in-intracerebral-hemorrhage
#16
Mario Di Napoli, Réza Behrouz, Christopher H Topel, Vivek Misra, Fulvio Pomero, Alessia Giraudo, Paolo Pennati, Luca Masotti, Floris H B M Schreuder, Julie Staals, Catharina J M Klijn, Craig J Smith, Adrian R Parry-Jones, Mark A Slevin, Brian Silver, Joshua Z Willey, Mahmoud R Azarpazhooh, Jaime Masjuán Vallejo, Hipólito Nzwalo, Aurel Popa-Wagner, Daniel A Godoy
PURPOSE: Hypoalbuminemia and systemic inflammatory response syndrome (SIRS) are reported in critically-ill patients, but their relationship is unclear. We sought to determine the association of admission serum albumin and SIRS with outcomes in patients with intracerebral hemorrhage (ICH). METHODS: We used a multicenter, multinational registry of ICH patients to select patients in whom SIRS parameters and serum albumin levels had been determined on admission. Hypoalbuminemia was defined as the lowest standardized quartile of albumin; SIRS according to standard criteria...
June 1, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28581996/in-hospital-st-elevation-myocardial-infarction-clinical-characteristics-management-challenges-and-outcome
#17
REVIEW
Xuming Dai, Ross F Garberich, Brian E Jaski, Sidney C Smith, Timothy D Henry
Timely reperfusion therapy reduces complications and improves survival in ST elevation myocardial infarction (STEMI). An effective chain of survival has been established for STEMIs occur in the community (outpatient STEMI). Recent studies have identified a subgroup of patients who develop STEMI while hospitalized for primary conditions, often not directly related to coronary artery disease (in-hospital STEMI or inpatient STEMI). This article summarizes current understanding of patient demographics, clinical characteristics, care delivery system and outcomes of in-hospital STEMI, comparing with outpatient STEMI...
October 2016: Interventional cardiology clinics
https://www.readbyqxmd.com/read/28578629/chaetomiaceae-fungi-novel-pathogens-of-equine-neurotropic-phaeohyphomycosis
#18
Quinci Plumlee, Courtney Meason-Smith, Alexandra Dieterly, Gabriel Gomez, Brian F Porter, Aline Rodrigues Hoffmann
Many previously unrecognized fungi are emerging as potential pathogens. One such group is dematiaceous fungi of the Chaetomiaceae family (phylum Ascomycota, class Sordariomycetes). These fungi are rare causes of opportunistic, neurotropic phaeohyphomycosis in humans but are not known to cause similar infections in animals. The aims of this study were to investigate equine hyphal mycotic encephalitis, characterize key histopathologic features, and classify causative organisms with molecular diagnostic techniques...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28578312/a-next-generation-trk-kinase-inhibitor-overcomes-acquired-resistance-to-prior-trk-kinase-inhibition-in-patients-with-trk-fusion-positive-solid-tumors
#19
Alexander Drilon, Ramamoorthy Nagasubramanian, James F Blake, Nora Ku, Brian B Tuch, Kevin Ebata, Steve Smith, Veronique Lauriault, Gabrielle R Kolakowski, Barbara J Brandhuber, Paul D Larsen, Karyn S Bouhana, Shannon L Winski, Robyn Hamor, Wen-I Wu, Andrew Parker, Tony H Morales, Francis X Sullivan, Walter E Dewolf, Lance A Wollenberg, Paul R Gordon, Dorothea N Douglas-Lindsay, Maurizio Scaltriti, Ryma Benayed, Sandeep Raj, Bethany Hanusch, Alison M Schram, Philip Jonsson, Michael F Berger, Jaclyn F Hechtman, Barry S Taylor, Steve Andrews, S Michael Rothenberg, David M Hyman
Larotrectinib, a selective TRK tyrosine kinase inhibitor (TKI), has demonstrated histology-agnostic efficacy in patients with TRK fusion-positive cancers. While responses to TRK inhibition can be dramatic and durable, duration of response may eventually be limited by acquired resistance. LOXO-195 is a novel, selective TRK TKI designed to overcome acquired resistance mediated by recurrent kinase domain (solvent front and xDFG) mutations identified in multiple patients who have developed resistance to TRK TKIs...
June 3, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28574669/cross-site-randomized-control-trial-of-the-social-abcs-caregiver-mediated-intervention-for-toddlers-with-autism-spectrum-disorder
#20
Jessica A Brian, Isabel M Smith, Lonnie Zwaigenbaum, Susan E Bryson
To evaluate the efficacy of the Social ABCs parent-mediated intervention for toddlers with suspected or confirmed autism spectrum disorder (ASD), through a cross-site randomized control trial, sixty-three parent-toddler dyads (toddler age: 16-30 months) were randomized into treatment (Social ABCs) or control (service-as-usual) conditions. Video data were obtained at three key time-points: Baseline; Post-training (PT; week 12); and Follow-Up (week 24). Analyses included 62 dyads. Treatment allocation significantly accounted for PT gains, all favouring the Treatment group, in (1) child functional vocal responsiveness to parent prompts (R(2)  = 0...
June 2, 2017: Autism Research: Official Journal of the International Society for Autism Research
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