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Brian smith

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https://www.readbyqxmd.com/read/28918054/rapid-and-sensitive-detection-of-breast-cancer-cells-in-patient-blood-with-nuclease-activated-probe-technology
#1
Sven Kruspe, David D Dickey, Kevin T Urak, Giselle N Blanco, Matthew J Miller, Karen C Clark, Elliot Burghardt, Wade R Gutierrez, Sneha D Phadke, Sukriti Kamboj, Timothy Ginader, Brian J Smith, Sarah K Grimm, James Schappet, Howard Ozer, Alexandra Thomas, James O McNamara, Carlos H Chan, Paloma H Giangrande
A challenge for circulating tumor cell (CTC)-based diagnostics is the development of simple and inexpensive methods that reliably detect the diverse cells that make up CTCs. CTC-derived nucleases are one category of proteins that could be exploited to meet this challenge. Advantages of nucleases as CTC biomarkers include: (1) their elevated expression in many cancer cells, including cells implicated in metastasis that have undergone epithelial-to-mesenchymal transition; and (2) their enzymatic activity, which can be exploited for signal amplification in detection methods...
September 15, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28916704/delayed-neutrophil-apoptosis-enhances-net-formation-in-cystic-fibrosis
#2
Robert D Gray, Gareth Hardisty, Kate H Regan, Maeve Smith, Calum T Robb, Rodger Duffin, Annie Mackellar, Jennifer M Felton, Lily Paemka, Brian N McCullagh, Christopher D Lucas, David A Dorward, Edward F McKone, Gordon Cooke, Seamas C Donnelly, Pradeep K Singh, David A Stoltz, Christopher Haslett, Paul B McCray, Moira K B Whyte, Adriano G Rossi, Donald J Davidson
BACKGROUND: Cystic fibrosis (CF) lung disease is defined by large numbers of neutrophils and associated damaging products in the airway. Delayed neutrophil apoptosis is described in CF although it is unclear whether this is a primary neutrophil defect or a response to chronic inflammation. Increased levels of neutrophil extracellular traps (NETs) have been measured in CF and we aimed to investigate the causal relationship between these phenomena and their potential to serve as a driver of inflammation...
September 15, 2017: Thorax
https://www.readbyqxmd.com/read/28914144/impaired-disengagement-of-attention-and-its-relationship-to-emotional-distress-in-infants-at-high-risk-for-autism-spectrum-disorder
#3
Susan Bryson, Nancy Garon, Tracey McMullen, Jessica Brian, Lonnie Zwaigenbaum, Vickie Armstrong, Wendy Roberts, Isabel Smith, Peter Szatmari
INTRODUCTION: We provide data on visual orienting and emotional distress in infants at high and low risk for autism spectrum disorder (ASD). METHOD: Participants included 83 high-risk (HR) infants with an older sibling with ASD and 53 low-risk (LR) control infants with no family history of ASD. Infants were assessed on the gap-overlap task and a parent-completed temperament questionnaire at 6 and 12 months of age. At 36 months of age, an independent, gold standard diagnostic assessment for ASD was conducted...
September 15, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28912790/development-and-evaluation-of-glycine-max-germplasm-lines-with-quantitative-resistance-to-sclerotinia-sclerotiorum
#4
Megan McCaghey, Jaime Willbur, Ashish Ranjan, Craig R Grau, Scott Chapman, Brian Diers, Carol Groves, Mehdi Kabbage, Damon L Smith
Sclerotinia sclerotiorum, the causal agent of Sclerotinia stem rot, is a devastating fungal pathogen of soybean that can cause significant yield losses to growers when environmental conditions are favorable for the disease. The development of resistant varieties has proven difficult. However, poor resistance in commercial cultivars can be improved through additional breeding efforts and understanding the genetic basis of resistance. The objective of this project was to develop soybean germplasm lines that have a high level of Sclerotinia stem rot resistance to be used directly as cultivars or in breeding programs as a source of improved Sclerotinia stem rot resistance...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28910473/optimization-of-simulation-and-moulage-in-military-related-medical-training
#5
Christopher Petersen, Stephen C Rush, Isabelle Gallo, Bryan Dalere, Brian Staak, Litt Moore, Win Kerr, Matthew Chandler, Will Smith
Preparation of Special Operations Forces (SOF) Medics as first responders for the battle space and austere environments is critical to optimize survival and quality of life for our Operators who may sustain serious and complex wounding patterns and illnesses. In the absence of constant clinical exposure for these medics, it is necessary to maximize all available training opportunities. The incorporation of scenario-based training helps weave together teamwork and the ability to practice treatment protocols in a tactical, controlled training environment to reproduce, to some degree, the environment in and stressors under which care will need to be delivered...
2017: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://www.readbyqxmd.com/read/28903057/failure-of-non-vacuum-steam-sterilization-processes-for-dental-handpieces
#6
S Winter, Andrew Smith, David Lappin, George McDonagh, Brian Kirk
BACKGROUND: Dental handpieces are used in critical and semi-critical operative interventions. Although a number of dental professional bodies recommend that dental handpieces are sterilized between patient use there is a lack of clarity and understanding of the effectiveness of different steam sterilization processes. The internal mechanisms of dental handpieces contain narrow lumens (0·8-2·3mm) which can impede the removal of air and ingress of saturated steam required to achieve sterilization conditions...
September 10, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28895928/collaborative-visual-analytics-a-health-analytics-approach-to-injury-prevention
#7
Samar Al-Hajj, Brian Fisher, Jennifer Smith, Ian Pike
Background: Accurate understanding of complex health data is critical in order to deal with wicked health problems and make timely decisions. Wicked problems refer to ill-structured and dynamic problems that combine multidimensional elements, which often preclude the conventional problem solving approach. This pilot study introduces visual analytics (VA) methods to multi-stakeholder decision-making sessions about child injury prevention; Methods: Inspired by the Delphi method, we introduced a novel methodology-group analytics (GA)...
September 12, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28893774/external-evaluation-of-two-fluconazole-infant-population-pharmacokinetic-models
#8
Michael F Hwang, Ryan J Beechinor, Kelly C Wade, Daniel K Benjamin, P Brian Smith, Christoph P Hornik, Edmund V Capparelli, Shahnaz Duara, Kathleen A Kennedy, Michael Cohen-Wolkowiez, Daniel Gonzalez
Fluconazole is an antifungal agent used for the treatment of invasive candidiasis, a leading cause of morbidity and mortality in premature infants. Population pharmacokinetics (PK) models of fluconazole in infants have been previously published by Wade et al. and Momper et al. Here we report the results of the first external evaluation of the predictive performance of both models. We used patient level data from both studies to externally evaluate both PK models. The predictive performance of each model was evaluated using the model prediction error (PE), mean prediction error (MPE), mean absolute prediction error (MAPE), prediction-corrected visual predictive check (pcVPC), and normalized prediction distribution errors (NPDE)...
September 11, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28893635/emendation-and-new-species-of-hapalorhynchus-stunkard-1922-digenea-schistosomatoidea-from-musk-turtles-kinosternidae-sternotherus-in-alabama-and-florida-rivers
#9
Jackson R Roberts, Kenneth M Halanych, Cova R Arias, Brian Folt, Jeffrey M Goessling, Stephen A Bullard
Hapalorhynchus Stunkard, 1922 is emended based on morphological study of existing museum specimens (type and voucher specimens) and newly-collected specimens infecting musk turtles (Testudines: Kinosternidae: Sternotherus spp.) from rivers in Alabama and Florida (USA). Hapalorhynchus conecuhensis n. sp. is described from an innominate musk turtle, Sternotherus cf. minor, (type host) from Blue Spring (31°5'27.64″N, 86°30'53.21″W; Pensacola Bay Basin, Alabama) and the loggerhead musk turtle, Sternotherus minor (Agassiz, 1857) from the Wacissa River (30°20'24...
September 8, 2017: Parasitology International
https://www.readbyqxmd.com/read/28892249/mandatory-reporting-by-doctors-of-medically-unsafe-drivers-is-unpopular-and-poorly-adhered-to-a-survey-of-sleep-physicians-and-electro-physicians
#10
Nathan J Elgar, Brian J Smith
BACKGROUND: Medical fitness to drive is one way governments control the issuing and renewal of driving licences and some jurisdictions demand mandatory reporting of unsafe drivers by doctors. AIM: We wished to determine the views, adherence rate and experiences of sleep physicians and electro-physicians with regard to South Australia's mandatory reporting law. METHODS: Self-administered surveys were delivered by post and e-mail to all South Australian Medical Board registered sleep physicians (n=49) and electro-physicians (n=11)...
September 11, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28891153/a-randomized-trial-of-off-site-collaborative-care-for-depression-in-chronic-hepatitis-c-virus
#11
Fasiha Kanwal, Jeffrey M Pyne, Shahriar Tavakoli-Tabasi, Susan Nicholson, Brian Dieckgraefe, Erma Storay, Matthew Bidwell Goetz, Jennifer R Kramer, Donna Smith, Shubhada Sansgiry, Aylin Tansel, Allen L Gifford, Steven M Asch
OBJECTIVE: To test the effectiveness of a collaborative depression care model in improving depression and hepatitis C virus (HCV) care. DATA SOURCES/STUDY SETTING: Hepatitis C virus clinic patients who screened positive for depression at four Veterans Affairs Hospitals. STUDY DESIGN: We compared off-site depression collaborative care (delivered by depression care manager, pharmacist, and psychiatrist) with usual care in a randomized trial...
September 11, 2017: Health Services Research
https://www.readbyqxmd.com/read/28890204/early-caffeine-prophylaxis-and-risk-of-failure-of-initial-continuous-positive-airway-pressure-in-very-low-birth-weight-infants
#12
Ravi M Patel, Kanecia Zimmerman, David P Carlton, Reese Clark, Daniel K Benjamin, P Brian Smith
OBJECTIVE: To test the hypothesis that early caffeine treatment on the day of birth, compared with later treatment in very low birth weight (VLBW, <1500 g) infants receiving continuous positive airway pressure (CPAP) therapy, is associated with a decreased risk of CPAP failure in the first week of life. STUDY DESIGN: Multicenter, observational cohort study in 366 US neonatal intensive care units. We evaluated inborn, VLBW infants discharged from 2000 to 2014, who received only CPAP therapy without surfactant treatment on day of life (DOL) 0, had a 5-minute Apgar ≥3, and received caffeine in first week of life...
September 7, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28890116/dermatologic-conditions-and-risk-of-suicide-a-case-control-study
#13
Deepak Prabhakar, Edward L Peterson, Yong Hu, Rebecca C Rossom, Frances L Lynch, Christine Y Lu, Beth E Waitzfelder, Ashli A Owen-Smith, L Keoki Williams, Arne Beck, Gregory E Simon, Brian K Ahmedani
BACKGROUND: Patients diagnosed with skin conditions have a higher risk of comorbid psychiatric conditions and suicide-related outcomes such as suicidal ideations and behaviors. There is paucity of evidence in the US general population about the risk of suicide death in patients with dermatologic conditions. METHODS: We conducted a retrospective case-control study to investigate the risk of suicide death in patients receiving care for dermatologic conditions. This study involved 8 US health systems...
August 4, 2017: Psychosomatics
https://www.readbyqxmd.com/read/28888403/transitioning-from-a-level-ii-to-level-i-trauma-center-increases-resident-patient-exposure
#14
Brian Carpenter, Lena Levine, Tim Niacaris, Sumihiro Suzuki
Increased patient exposure has been shown to improve residency training as determined by better patient outcomes. The transition of John Peter Smith Hospital from a level II to a level I trauma center in 2009 provided a unique opportunity to investigate the direct effects of increased patient exposure on residency training in a relatively controlled setting. We evaluated the effect of the transition to a level I trauma center on residency training. In 2014, we examined the annual facility reports and separated the data into 2 groups: level II (2001 to 2008) and level I (2010 to 2013)...
September 6, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28883928/cpap-impact-a-protocol-for-a-randomised-trial-of-bubble-continuous-positive-airway-pressure-versus-standard-care-for-high-risk-children-with-severe-pneumonia-using-adaptive-design-methods
#15
Andrew G Smith, Michelle Eckerle, Tisungane Mvalo, Brian Weir, Francis Martinson, Alfred Chalira, Norman Lufesi, Innocent Mofolo, Mina Hosseinipour, Eric D McCollum
INTRODUCTION: Pneumonia is a leading cause of mortality among children in low-resource settings. Mortality is greatest among children with high-risk conditions including HIV infection or exposure, severe malnutrition and/or severe hypoxaemia. WHO treatment recommendations include low-flow oxygen for children with severe pneumonia. Bubble continuous positive airway pressure (bCPAP) is a non-invasive support modality that provides positive end-expiratory pressure and oxygen. bCPAP is effective in the treatment of neonates in low-resource settings; its efficacy is unknown for high-risk children with severe pneumonia in low-resource settings...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/28881006/simple-aspiration-versus-intercostal-tube-drainage-for-primary-spontaneous-pneumothorax-in-adults
#16
REVIEW
Kristin V Carson-Chahhoud, Abel Wakai, Joseph Em van Agteren, Brian J Smith, Grainne McCabe, Malcolm P Brinn, Ronan O'Sullivan
BACKGROUND: For management of pneumothorax that occurs without underlying lung disease, also referred to as primary spontaneous pneumothorax, simple aspiration is technically easier to perform than intercostal tube drainage. In this systematic review, we seek to compare the clinical efficacy and safety of simple aspiration versus intercostal tube drainage for management of primary spontaneous pneumothorax. This review was first published in 2007 and was updated in 2017. OBJECTIVES: To compare the clinical efficacy and safety of simple aspiration versus intercostal tube drainage for management of primary spontaneous pneumothorax...
September 7, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28880104/intimate-relationships-individual-adjustment-and-coronary-heart-disease-implications-of-overlapping-associations-in-psychosocial-risk
#17
Timothy W Smith, Brian R W Baucom
Being married or involved in a similar intimate relationship is associated with reduced risk of coronary heart disease (CHD). However, the quality of these relationships matters, as strain and disruption are associated with increased risk. These effects are typically studied separately from well-established psychosocial factors for CHD that are aspects of personality and emotional adjustment, even though discord and disruption in intimate relationships are related to these same individual characteristics. Thus, research to date tends to parse correlated risks, often taking a piecemeal approach by focusing on intimate relationships without considering aspects of personality and emotional adjustment that contribute to risk and protection, or focusing on individual-level risks while largely ignoring closely related health-relevant relationships...
September 2017: American Psychologist
https://www.readbyqxmd.com/read/28879629/feasibility-of-coping-effectiveness-training-for-caregivers-of-children-with-autism-spectrum-disorder-a-genetic-counseling-intervention
#18
Christy Haakonsen Smith, Erin Turbitt, John Muschelli, Lori Leonard, Katie L Lewis, Brian Freedman, Michelle Muratori, Barbara B Biesecker
Caregivers of children with autism spectrum disorder (ASD) may find it difficult to feel a sense of control and to cope with the overall physical and emotional demands of caring for their child. While caregivers are able to successfully cope with a high level of stress, there are limits to their resources and abilities to cope over time. Genetic counselors working with affected families may be able to help parents more effectively manage stress related to the disorder. Few short-term interventions have been reported in genetic counseling yet implementation of evidence-based examples may be achievable...
September 6, 2017: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/28878985/task-allocation-and-site-fidelity-jointly-influence-foraging-regulation-in-honeybee-colonies
#19
Thiago Mosqueiro, Chelsea Cook, Ramon Huerta, Jürgen Gadau, Brian Smith, Noa Pinter-Wollman
Variation in behaviour among group members often impacts collective outcomes. Individuals may vary both in the task that they perform and in the persistence with which they perform each task. Although both the distribution of individuals among tasks and differences among individuals in behavioural persistence can each impact collective behaviour, we do not know if and how they jointly affect collective outcomes. Here, we use a detailed computational model to examine the joint impact of colony-level distribution among tasks and behavioural persistence of individuals, specifically their fidelity to particular resource sites, on the collective trade-off between exploring for new resources and exploiting familiar ones...
August 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28875166/observation-of-prethermalization-in-long-range-interacting-spin-chains
#20
Brian Neyenhuis, Jiehang Zhang, Paul W Hess, Jacob Smith, Aaron C Lee, Phil Richerme, Zhe-Xuan Gong, Alexey V Gorshkov, Christopher Monroe
Although statistical mechanics describes thermal equilibrium states, these states may or may not emerge dynamically for a subsystem of an isolated quantum many-body system. For instance, quantum systems that are near-integrable usually fail to thermalize in an experimentally realistic time scale, and instead relax to quasi-stationary prethermal states that can be described by statistical mechanics, when approximately conserved quantities are included in a generalized Gibbs ensemble (GGE). We experimentally study the relaxation dynamics of a chain of up to 22 spins evolving under a long-range transverse-field Ising Hamiltonian following a sudden quench...
August 2017: Science Advances
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