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JOURNAL ARTICLE
Anne Pelletier Cameron, Doreen E Chung, Elodi J Dielubanza, Ekene Enemchukwu, David A Ginsberg, Brian T Helfand, Penny Holland, Brian J Linder, Leila Rahimi, W Stuart Reynolds, Eric S Rovner, Lesley Souter, Anne M Suskind, Elizabeth Takacs, Blayne Welk, Ariana L Smith
PURPOSE: The purpose of this guideline is to provide evidence-based guidance to clinicians of all specialties on the evaluation, management, and treatment of idiopathic overactive bladder (OAB). The guideline informs the reader on valid diagnostic processes and provides an approach to selecting treatment options for patients with OAB through the shared decision-making process that will maximize symptom control and quality of life, while minimizing adverse events and burden of disease...
April 23, 2024: Journal of Urology
#2
JOURNAL ARTICLE
Julia R Port, Jade C Riopelle, Samuel G Smith, Lara Myers, Franziska K Kaiser, Matthew C Lewis, Shane Gallogly, Atsushi Okumura, Trent Bushmaker, Jonathan E Schulz, Rebecca Rosenke, Jessica Prado-Smith, Aaron Carmody, Sidy Bane, Brian J Smith, Greg Saturday, Heinz Feldmann, Kyle Rosenke, Vincent J Munster
The 2022 mpox virus (MPXV) outbreak was sustained by human-to-human transmission; however, it is currently unclear which factors lead to sustained transmission of MPXV. Here we present Mastomys natalensis as a model for MPXV transmission after intraperitoneal, rectal, vaginal, aerosol and transdermal inoculation with an early 2022 human outbreak isolate (Clade IIb). Virus shedding and tissue replication were route dependent and occurred in the presence of self-resolving localized skin, lung, reproductive tract or rectal lesions...
April 22, 2024: Nature Microbiology
#3
JOURNAL ARTICLE
Michael J Turnbull, Iwen Grigsby, Karl Unertl, Kerry Sokol, Tera Nordby, Cedric Liu, Anna Bailey, Brian Spiewak, Graham Smith, Amy K McNulty
BACKGROUND: Medical tapes can lead to skin damage upon removal in susceptible patients with fragile skin and at higher risk of developing tissue injury. PURPOSE: We compared the effect of medical tapes with silicone-based versus acrylate-based adhesives on the back or volar forearm stratum corneum using analytical techniques to assess skin condition and potential damage post product removal on 88 healthy volunteers. METHODS: Two studies were conducted in separate facilities (Study 1: 3M In-house Clinical Facility, St...
March 2024: Curēus
#4
Nick Shrine, Anna L Guyatt, A Mesut Erzurumluoglu, Victoria E Jackson, Brian D Hobbs, Carl A Melbourne, Chiara Batini, Katherine A Fawcett, Kijoung Song, Phuwanat Sakornsakolpat, Xingnan Li, Ruth Boxall, Nicola F Reeve, Ma'en Obeidat, Jing Hua Zhao, Matthias Wielscher, Stefan Weiss, Katherine A Kentistou, James P Cook, Benjamin B Sun, Jian Zhou, Jennie Hui, Stefan Karrasch, Medea Imboden, Sarah E Harris, Jonathan Marten, Stefan Enroth, Shona M Kerr, Ida Surakka, Veronique Vitart, Terho Lehtimäki, Richard J Allen, Per S Bakke, Terri H Beaty, Eugene R Bleecker, Yohan Bossé, Corry-Anke Brandsma, Zhengming Chen, James D Crapo, John Danesh, Dawn L DeMeo, Frank Dudbridge, Ralf Ewert, Christian Gieger, Amund Gulsvik, Anna L Hansell, Ke Hao, Joshua D Hoffman, John E Hokanson, Georg Homuth, Peter K Joshi, Philippe Joubert, Claudia Langenberg, Xuan Li, Liming Li, Kuang Lin, Lars Lind, Nicholas Locantore, Jian'an Luan, Anubha Mahajan, Joseph C Maranville, Alison Murray, David C Nickle, Richard Packer, Margaret M Parker, Megan L Paynton, David J Porteous, Dmitry Prokopenko, Dandi Qiao, Rajesh Rawal, Heiko Runz, Ian Sayers, Don D Sin, Blair H Smith, María Soler Artigas, David Sparrow, Ruth Tal-Singer, Paul R H J Timmers, Maarten Van den Berge, John C Whittaker, Prescott G Woodruff, Laura M Yerges-Armstrong, Olga G Troyanskaya, Olli T Raitakari, Mika Kähönen, Ozren Polašek, Ulf Gyllensten, Igor Rudan, Ian J Deary, Nicole M Probst-Hensch, Holger Schulz, Alan L James, James F Wilson, Beate Stubbe, Eleftheria Zeggini, Marjo-Riitta Jarvelin, Nick Wareham, Edwin K Silverman, Caroline Hayward, Andrew P Morris, Adam S Butterworth, Robert A Scott, Robin G Walters, Deborah A Meyers, Michael H Cho, David P Strachan, Ian P Hall, Martin D Tobin, Louise V Wain
No abstract text is available yet for this article.
April 19, 2024: Nature Genetics
#5
JOURNAL ARTICLE
Shannon T Smith, Jackson B Cassada, Lukas Von Bredow, Kevin Erreger, Emma M Webb, Trevor A Trombley, Jacob J Kalbfleisch, Brian J Bender, Irene Zagol-Ikapitte, Valerie M Kramlinger, Jacob L Bouchard, Sidnee G Mitchell, Maik Tretbar, Brian K Shoichet, Craig W Lindsley, Jens Meiler, Heidi E Hamm
Here, we demonstrate a structure-based small molecule virtual screening and lead optimization pipeline using a homology model of a difficult-to-drug G-protein-coupled receptor (GPCR) target. Protease-activated receptor 4 (PAR4) is activated by thrombin cleavage, revealing a tethered ligand that activates the receptor, making PAR4 a challenging target. A virtual screen of a make-on-demand chemical library yielded a one-hit compound. From the single-hit compound, we developed a novel series of PAR4 antagonists...
April 12, 2024: ACS Pharmacology & Translational Science
#6
JOURNAL ARTICLE
Sung-Mok Jung, Sara L Loo, Emily Howerton, Lucie Contamin, Claire P Smith, Erica C Carcelén, Katie Yan, Samantha J Bents, John Levander, Jessi Espino, Joseph C Lemaitre, Koji Sato, Clifton D McKee, Alison L Hill, Matteo Chinazzi, Jessica T Davis, Kunpeng Mu, Alessandro Vespignani, Erik T Rosenstrom, Sebastian A Rodriguez-Cartes, Julie S Ivy, Maria E Mayorga, Julie L Swann, Guido España, Sean Cavany, Sean M Moore, T Alex Perkins, Shi Chen, Rajib Paul, Daniel Janies, Jean-Claude Thill, Ajitesh Srivastava, Majd Al Aawar, Kaiming Bi, Shraddha Ramdas Bandekar, Anass Bouchnita, Spencer J Fox, Lauren Ancel Meyers, Przemyslaw Porebski, Srini Venkatramanan, Aniruddha Adiga, Benjamin Hurt, Brian Klahn, Joseph Outten, Jiangzhuo Chen, Henning Mortveit, Amanda Wilson, Stefan Hoops, Parantapa Bhattacharya, Dustin Machi, Anil Vullikanti, Bryan Lewis, Madhav Marathe, Harry Hochheiser, Michael C Runge, Katriona Shea, Shaun Truelove, Cécile Viboud, Justin Lessler
BACKGROUND: Coronavirus Disease 2019 (COVID-19) continues to cause significant hospitalizations and deaths in the United States. Its continued burden and the impact of annually reformulated vaccines remain unclear. Here, we present projections of COVID-19 hospitalizations and deaths in the United States for the next 2 years under 2 plausible assumptions about immune escape (20% per year and 50% per year) and 3 possible CDC recommendations for the use of annually reformulated vaccines (no recommendation, vaccination for those aged 65 years and over, vaccination for all eligible age groups based on FDA approval)...
April 17, 2024: PLoS Medicine
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JOURNAL ARTICLE
Liana R Andronescu, Stephanie A Richard, Ann I Scher, David A Lindholm, Katrin Mende, Anuradha Ganesan, Nikhil Huprikar, Tahaniyat Lalani, Alfred Smith, Rupal M Mody, Milissa U Jones, Samantha E Bazan, Rhonda E Colombo, Christopher J Colombo, Evan Ewers, Derek T Larson, Ryan C Maves, Catherine M Berjohn, Carlos J Maldonado, Caroline English, Margaret Sanchez Edwards, Julia S Rozman, Jennifer Rusiecki, Celia Byrne, Mark P Simons, David Tribble, Timothy H Burgess, Simon D Pollett, Brian K Agan
BACKGROUND: Chronic neuropsychological sequelae following SARS-CoV-2 infection, including depression, anxiety, fatigue, and general cognitive difficulties, are a major public health concern. Given the potential impact of long-term neuropsychological impairment, it is important to characterize the frequency and predictors of this post-infection phenotype. METHODS: The Epidemiology, Immunology, and Clinical Characteristics of Emerging Infectious Diseases with Pandemic Potential (EPICC) study is a longitudinal study assessing the impact of SARS-CoV-2 infection in U...
2024: PloS One
#8
JOURNAL ARTICLE
Coral L Shuster, Patricia A Brennan, Brian S Carter, Jennifer Check, Viren D'Sa, Joyce C Graff, Jennifer Helderman, Julie A Hofheimer, Robert M Joseph, Laura E Murphy, Thomas G O'Connor, T Michael O'Shea, Michelle Pievsky, Stephen J Sheinkopf, Lauren C Shuffrey, Lynne M Smith, Pei-Chi Wu, Barry M Lester
BACKGROUND: The Modified Checklist for Autism in Toddlers (M-CHAT) is a common pediatric screening tool with mixed accuracy findings. Prior evidence supports M-CHAT screening for developmental concerns, especially in toddlers born preterm. This study examined M-CHAT accuracy in a large, nationwide sample. METHODS: 3393 participants from the Environmental influences on Child Health Outcomes (ECHO) program were included. Harmonized M-CHAT (M-CHAT-H) results were compared with parent-reported autism diagnosis and autism-related characteristics to assess accuracy for term and preterm children, together and separately...
April 15, 2024: Pediatric Research
#9
JOURNAL ARTICLE
Lori A Devlin, Zhuopei Hu, Stephanie L Merhar, Songthip T Ounpraseuth, Alan E Simon, Jeannette Y Lee, Abhik Das, Margaret M Crawford, Rachel G Greenberg, P Brian Smith, Rosemary D Higgins, Michele C Walsh, Ward Rice, David A Paul, Jessie R Maxwell, Camille M Fung, Tanner Wright, Julie Ross, Jennifer M McAllister, Moira Crowley, Sophie K Shaikh, Lori Christ, Jaime Brown, Julie Riccio, Kara Wong Ramsey, Erica F Braswell, Lauren Tucker, Karen McAlmon, Krishna Dummula, Julie Weiner, Jessica R White, Sarah Newman, Jessica N Snowden, Leslie W Young
IMPORTANCE: The function-based eat, sleep, console (ESC) care approach substantially reduces the proportion of infants who receive pharmacologic treatment for neonatal opioid withdrawal syndrome (NOWS). This reduction has led to concerns for increased postnatal opioid exposure in infants who receive pharmacologic treatment. However, the effect of the ESC care approach on hospital outcomes for infants pharmacologically treated for NOWS is currently unknown. OBJECTIVE: To evaluate differences in opioid exposure and total length of hospital stay (LOS) for pharmacologically treated infants managed with the ESC care approach vs usual care with the Finnegan tool...
April 15, 2024: JAMA Pediatrics
#10
JOURNAL ARTICLE
Rachel L Zelkowitz, Kelsey N Serier, Brian N Smith, Shannon Kehle-Forbes, Dawne S Vogt, Karen S Mitchell
OBJECTIVE: Comorbidity between posttraumatic stress disorder (PTSD) and disordered eating (DE) symptoms is common, reflecting a possible reciprocal relationship between these disorders. Network analysis may reveal candidate mechanisms underlying their comorbidity and highlight important treatment targets. METHOD: Two national samples of U.S. veterans endorsing trauma exposure self-reported PTSD and DE symptoms. The discovery sample included veterans from all service eras ( n = 434)...
April 15, 2024: Psychological Trauma: Theory, Research, Practice and Policy
#11
JOURNAL ARTICLE
Rachel A Jones Lipinski, Jennifer S Stancill, Raymundo Nuñez, Sarah L Wynia-Smith, Daniel J Sprague, Joshua A Nord, Amir Bird, John A Corbett, Brian C Smith
Inhibition of the bromodomain and extraterminal domain (BET) protein family is a potential strategy to prevent and treat diabetes; however, the clinical use of BET bromodomain inhibitors (BETi) is associated with adverse effects. Here, we explore a strategy for targeting BETi to β-cells by exploiting the high zinc (Zn2+ ) concentration in β-cells relative to other cell types. We report the synthesis of a novel, Zn2+ -chelating derivative of the pan-BETi (+)-JQ1, (+)-JQ1-DPA, in which (+)-JQ1 was conjugated to dipicolyl amine (DPA)...
April 15, 2024: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
#12
JOURNAL ARTICLE
Matheus Sewastjanow-Silva, Lianchun Xiao, Graciela N Gonzalez, Xuemei Wang, Wayne Hofstetter, Stephen Swisher, Reza Mehran, Boris Sepesi, Manoop S Bhutani, Brian Weston, Emmanuel Coronel, Rebecca E Waters, Jane E Rogers, Jackie Smith, Larry Lyons, Norelle Reilly, James C Yao, Jaffer A Ajani, Mariela Blum Murphy
Efforts to improve the prognosis for patients with locally advanced esophageal or gastroesophageal junction (GEJ) adenocarcinoma have focused on neoadjuvant approaches to increase the pathological complete response (pathCR) rate, improve surgical resection, and prolong event-free and overall survival (OS). Building on the recent evidence that PD-1 inhibition plus chemotherapy improves the OS of patients with metastatic GEJ adenocarcinoma, we evaluated whether the application of this strategy in the neoadjuvant setting would improve the pathological response...
March 31, 2024: Cancers
#13
JOURNAL ARTICLE
Hannah E Cabre, Alex N Ladan, Sam R Moore, Kelly E Joniak, Malia N M Blue, Brian G Pietrosimone, Anthony C Hackney, Abbie E Smith-Ryan
Cabre, HE, Ladan, AN, Moore, SR, Joniak, KE, Blue, MNM, Pietrosimone, BG, Hackney, AC, and Smith-Ryan, AE. Effects of hormonal contraception and the menstrual cycle on fatigability and recovery from an anaerobic exercise test. J Strength Cond Res XX(X): 000-000, 2024-This study sought to evaluate the effects of oral contraceptive (OC) and hormonal intrauterine device (H-IUD) use, compared with a eumenorrheic (EUM) cycle, on fatigability and recovery between hormone the phases. Peak power (PP), average power (AP), fatigue index (FI), blood lactate, vessel diameter, and blood flow (BF) were measured from a repeated sprint cycle test (10 × 6 seconds) in 60, healthy, active women (mean ± SD; age: 26...
April 9, 2024: Journal of Strength and Conditioning Research
#14
JOURNAL ARTICLE
Urszula N Wasko, Jingjing Jiang, Tanner C Dalton, Alvaro Curiel-Garcia, A Cole Edwards, Yingyun Wang, Bianca Lee, Margo Orlen, Sha Tian, Clint A Stalnecker, Kristina Drizyte-Miller, Marie Menard, Julien Dilly, Stephen A Sastra, Carmine F Palermo, Marie C Hasselluhn, Amanda R Decker-Farrell, Stephanie Chang, Lingyan Jiang, Xing Wei, Yu C Yang, Ciara Helland, Haley Courtney, Yevgeniy Gindin, Karl Muonio, Ruiping Zhao, Samantha B Kemp, Cynthia Clendenin, Rina Sor, William P Vostrejs, Priya S Hibshman, Amber M Amparo, Connor Hennessey, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Jens Brodbeck, Lorenzo Tomassoni, Basil Bakir, Nicholas D Socci, Laura E Herring, Natalie K Barker, Junning Wang, James M Cleary, Brian M Wolpin, John A Chabot, Michael D Kluger, Gulam A Manji, Kenneth Y Tsai, Miroslav Sekulic, Stephen M Lagana, Andrea Califano, Elsa Quintana, Zhengping Wang, Jacqueline A M Smith, Matthew Holderfield, David Wildes, Scott W Lowe, Michael A Badgley, Andrew J Aguirre, Robert H Vonderheide, Ben Z Stanger, Timour Baslan, Channing J Der, Mallika Singh, Kenneth P Olive
Broad-spectrum RAS inhibition holds the potential to benefit roughly a quarter of human cancer patients whose tumors are driven by RAS mutations1,2 . RMC-7977 is a highly selective inhibitor of the active GTP-bound forms of KRAS, HRAS, and NRAS, with affinity for both mutant and wild type (WT) variants (RAS(ON) multi-selective)3 . As >90% of human pancreatic ductal adenocarcinoma (PDAC) cases are driven by activating mutations in KRAS4 , we assessed the therapeutic potential of the RAS(ON) multi-selective inhibitor RMC-7977 in a comprehensive range of PDAC models...
April 8, 2024: Nature
#15
JOURNAL ARTICLE
Afua O Asare, Brian C Stagg, Nasser Sharareh, Carole Stipelman, Guilherme Del Fiol, Justin D Smith
The aim of this study was to determine whether immigrant generation is associated with caregiver-reported vision loss in children adjusting for sociodemographic characteristics. Nationally representative data from the National Survey of Children's Health (2018-2020) was used. The primary exposure was immigrant generation defined as: first (child and all reported parents were born outside the United States); second (child was born in the United States and at least one parent was born outside the United States); third or higher (all parents in the household were born in the United States)...
April 6, 2024: Journal of Immigrant and Minority Health
#16
JOURNAL ARTICLE
Elie Massaad, William J Smith, Joseph Bradley, Eric Esposito, Mihir Gupta, Evan Burns, Ryan Burns, José K Velarde, Inka K Berglar, Rajiv Gupta, Maria Martinez-Lage, Jorg Dietrich, Jochen K Lennerz, Gavin P Dunn, Pamela S Jones, Bryan D Choi, Albert E Kim, Matthew Frosch, Fred G Barker, William T Curry, Bob S Carter, Brian V Nahed, Daniel P Cahill, Ganesh M Shankar
BACKGROUND: Survival is variable in patients with glioblastoma IDH wild-type (GBM), even after comparable surgical resection of radiographically-detectable disease, highlighting the limitations of radiographic assessment of infiltrative tumor anatomy. The majority of post-surgical progressive events are failures within 2cm of the resection margin, motivating supramaximal resection strategies to improve local control. However, which patients benefit from such radical resections remains unknown...
April 6, 2024: Neuro-oncology
#17
JOURNAL ARTICLE
Michael Gofeld, Kevin J Smith, Anuj Bhatia, Vladimir Djuric, Suzanne Leblang, Niv Rebhun, Ron Aginsky, Eric Miller, Brian Skoglind, Arik Hananel
OBJECTIVE: The objective of this study is to investigate safety and effectiveness of a fluoroscopy-guided high-intensity focused ultrasound (HIFU) system for thermal ablation of the lumbar medial branch nerves. METHODS: This dual center prospective cohort study enrolled 30 participants with lumbar zygapophyseal joint syndrome. Each participant previously had a positive response to either a single diagnostic analgesic block or radiofrequency ablation (RFA). The primary effectiveness outcome was individual responder rate, defined as a reduction of two points or more on the pain intensity numerical rating scale without an increase in opioid intake, or a reduction in opioid intake without an increase in pain at 6 months after the intervention...
April 5, 2024: Regional Anesthesia and Pain Medicine
#18
Christopher J Ricketts, Aguirre A De Cubas, Huihui Fan, Christof C Smith, Martin Lang, Ed Reznik, Reanne Bowlby, Ewan A Gibb, Rehan Akbani, Rameen Beroukhim, Donald P Bottaro, Toni K Choueiri, Richard A Gibbs, Andrew K Godwin, Scott Haake, A Ari Hakimi, Elizabeth P Henske, James J Hsieh, Thai H Ho, Rupa S Kanchi, Bhavani Krishnan, David J Kwiatkowski, Wenbin Liu, Maria J Merino, Gordon B Mills, Jerome Myers, Michael L Nickerson, Victor E Reuter, Laura S Schmidt, C Simon Shelley, Hui Shen, Brian Shuch, Sabina Signoretti, Ramaprasad Srinivasan, Pheroze Tamboli, George Thomas, Benjamin G Vincent, Cathy D Vocke, David A Wheeler, Lixing Yang, William Y Kim, A Gordon Robertson, Paul T Spellman, W Kimryn Rathmell, W Marston Linehan
No abstract text is available yet for this article.
April 3, 2024: Cell Reports
#19
JOURNAL ARTICLE
Prashant D Tailor, Timothy T Xu, Blake H Fortes, Raymond Iezzi, Timothy W Olsen, Matthew R Starr, Sophie J Bakri, Brittni A Scruggs, Andrew J Barkmeier, Sanjay V Patel, Keith H Baratz, Ashlie A Bernhisel, Lilly H Wagner, Andrea A Tooley, Gavin W Roddy, Arthur J Sit, Kristi Y Wu, Erick D Bothun, Sasha A Mansukhani, Brian G Mohney, John J Chen, Michael C Brodsky, Deena A Tajfirouz, Kevin D Chodnicki, Wendy M Smith, Lauren A Dalvin
OBJECTIVE: To determine the appropriateness of ophthalmology recommendations from an online chat-based artificial intelligence model to ophthalmology questions. PATIENTS AND METHODS: Cross-sectional qualitative study from April 1, 2023, to April 30, 2023. A total of 192 questions were generated spanning all ophthalmic subspecialties. Each question was posed to a large language model (LLM) 3 times. The responses were graded by appropriate subspecialists as appropriate, inappropriate, or unreliable in 2 grading contexts...
March 2024: Mayo Clin Proc Digit Health
#20
Satish K Mehta, Rahul Suresh, Keith Brandt, Douglass M Diak, Scott M Smith, Sara R Zwart, Grace Douglas, Mayra Nelman-Gonzalez, Simon Clemett, Tyson Brunstetter, Brian E Crucian
A case report detailing, for the first time, a case of laboratory-confirmed zoster in an astronaut on board the International Space Station is presented. The findings of reduced T-cell function, cytokine imbalance, and increased stress hormones which preceded the event are detailed. Relevance for deep space countermeasures is discussed.
May 2024: J Allergy Clin Immunol Glob
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