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https://www.readbyqxmd.com/read/28526253/racial-ethnic-differences-in-sleep-quality-among-older-adults-with-osteoarthritis
#1
Patricia A Parmelee, Brian S Cox, Jason A DeCaro, Francis J Keefe, Dylan M Smith
OBJECTIVE: To examine racial/ethnic differences in sleep quality and the pain-sleep association among older adults with osteoarthritis of the knee. DESIGN: Baseline interview followed by a 7-day microlongitudinal study using accelerometry and self-reports. SETTING: Participants were community residents in western Alabama and Long Island, NY. PARTICIPANTS: Ninety-six African Americans (AAs) and 128 non-Hispanic whites (NHWs) with physician-diagnosed knee osteoarthritis, recruited from a variety of clinical and community settings...
June 2017: Sleep Health
https://www.readbyqxmd.com/read/28515359/t-cell-progenitor-therapy-facilitated-thymopoiesis-depends-upon-thymic-input-and-continued-thymic-microenvironment-interaction
#2
Michelle J Smith, Dawn K Reichenbach, Sarah L Parker, Megan J Riddle, Jason Mitchell, Kevin C Osum, Mahmood Mohtashami, Heather E Stefanski, Brian T Fife, Avinash Bhandoola, Kristin A Hogquist, Georg A Holländer, Juan Carlos Zúñiga-Pflücker, Jakub Tolar, Bruce R Blazar
Infusion of in vitro-derived T cell progenitor (proT) therapy with hematopoietic stem cell transplant aids the recovery of the thymus damaged by total body irradiation. To understand the interaction between proTs and the thymic microenvironment, WT mice were lethally irradiated and given T cell-deficient (Rag1-/-) marrow with WT in vitro-generated proTs, limiting mature T cell development to infused proTs. ProTs within the host thymus led to a significant increase in thymic epithelial cells (TECs) by day 21 after transplant, increasing actively cycling TECs...
May 18, 2017: JCI Insight
https://www.readbyqxmd.com/read/28505268/pharmacodynamics-of-dose-escalated-front-loading-polymyxin-b-regimens-against-polymyxin-resistant-mcr-1-harbouring-escherichia-coli
#3
Nicholas M Smith, Zackery P Bulman, Arthur O Sieron, Jürgen B Bulitta, Patricia N Holden, Roger L Nation, Jian Li, Gerard D Wright, Brian T Tsuji
Objectives: Gram-negative bacteria harbouring the mcr-1 plasmid are resistant to the 'last-line' polymyxins and have been reported worldwide. Our objective was to define the impact of increasing the initial polymyxin B dose intensity against an mcr-1 -harbouring strain to delineate the impact of plasmid-mediated polymyxin resistance on the dynamics of bacterial killing and resistance. Methods: A hollow fibre infection model (HFIM) was used to simulate polymyxin B regimens against an mcr-1 -harbouring Escherichia coli (MIC 8 mg/L) over 10 days...
May 15, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28501511/identification-of-quinazoline-based-inhibitors-of-irak4-for-the-treatment-of-inflammation
#4
Graham F Smith, Michael D Altman, Brian Andresen, James Baker, Jason D Brubaker, Hongmin Chen, Yiping Chen, Matthew Childers, Anthony Donofrio, Heidi Ferguson, Christian Fischer, Thierry O Fischmann, Craig Gibeau, Alexander Hicks, Sue Jin, Sam Kattar, Melanie A Kleinschek, Erica Leccese, Charles Lesburg, Chaomin Li, Jongwon Lim, Duan Liu, John K F Maclean, Faruk Mansoor, Lilly Y Moy, Erin F Mulrooney, Antoaneta S Necheva, Jeremy Presland, Larissa Rakhilina, Ruojing Yang, Luis Torres, Jie Zhang-Hoover, Alan Northrup
Interleukin-1 receptor associated kinase 4 (IRAK4) has been implicated in IL-1R and TLR based signaling. Therefore selective inhibition of the kinase activity of this protein represents an attractive target for the treatment of inflammatory diseases. Medicinal chemistry optimization of high throughput screening (HTS) hits with the help of structure based drug design led to the identification of orally-bioavailable quinazoline based IRAK4 inhibitors with excellent pharmacokinetic profile and kinase selectivity...
April 18, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28493744/does-menthol-cigarette-use-moderate-the-effect-of-nicotine-metabolism-on-short-term-smoking-cessation
#5
Nancy C Jao, Anna K Veluz-Wilkins, Matthew J Smith, Allison J Carroll, Sonja Blazekovic, Frank T Leone, Rachel F Tyndale, Robert A Schnoll, Brian Hitsman
The nicotine metabolite ratio (NMR) has been shown to predict response to the transdermal nicotine patch, such that faster nicotine metabolism is associated with a lower abstinence rate. Menthol cigarette use, versus nonmenthol cigarette use, slows nicotine metabolism and therefore may attenuate the effect of NMR on smoking abstinence. In this study, we evaluated whether cigarette type (menthol vs. nonmenthol) modified the association between NMR and short-term abstinence. This was a secondary analysis examining treatment in the first 8 weeks of 21 mg/day nicotine patch therapy in a completed clinical trial (n = 474)...
June 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28491071/exploring-blueberry-aroma-complexity-by-chromatographic-and-direct-injection-spectrometric-techniques
#6
Brian Farneti, Iuliia Khomenko, Marcella Grisenti, Matteo Ajelli, Emanuela Betta, Alberto Alarcon Algarra, Luca Cappellin, Eugenio Aprea, Flavia Gasperi, Franco Biasioli, Lara Giongo
Blueberry (Vaccinium spp.) fruit consumption has increased over the last 5 years, becoming the second most important soft fruit species after strawberry. Despite the possible economic and sensory impact, the blueberry volatile organic compound (VOC) composition has been poorly investigated. Thus, the great impact of the aroma on fruit marketability stimulates the need to step forward in the understanding of this quality trait. Beside the strong effect of ripening, blueberry aroma profile also varies due to the broad genetic differences among Vaccinium species that have been differently introgressed in modern commercial cultivars through breeding activity...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28490509/vitamin-d-and-calcium-intake-and-risk-of-early-menopause
#7
Alexandra C Purdue-Smithe, Brian W Whitcomb, Kathleen L Szegda, Maegan E Boutot, JoAnn E Manson, Susan E Hankinson, Bernard A Rosner, Lisa M Troy, Karin B Michels, Elizabeth R Bertone-Johnson
Background: Early menopause, defined as the cessation of ovarian function before the age of 45 y, affects ∼10% of women and is associated with higher risk of cardiovascular disease, osteoporosis, and other conditions. Few modifiable risk factors for early menopause have been identified, but emerging data suggest that high vitamin D intake may reduce risk.Objective: We evaluated how intakes of vitamin D and calcium are associated with the incidence of early menopause in the prospective Nurses' Health Study II (NHS2)...
May 10, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28486870/long-term-cardiac-morbidity-and-mortality-in-patients-with-aortic-valve-disease-following-liver-transplantation-a-case-matching-study
#8
Ramona Nicolau-Raducu, Thomas Marshall, Hamang Patel, Kelly Ural, Joseph Koveleskie, Susan Smith, Donald Ganier, Bryan Evans, Brian Fish, William Daly, Ari J Cohen, George Loss, Amjad Bokhari, Bobby Nossaman
INTRODUCTION: This retrospective study examined the role of aortic valve (AV) disease in patients who underwent orthotopic liver transplantation (OLT) to determine the incidence of postoperative cardiac morbidity and mortality when compared with a matched control group without AV disease. METHODS: Patients were included in the AV group if diagnosed with aortic stenosis (AS) or aortic regurgitation or had received AV replacement prior to OLT. The AV group (n = 53) was matched to a control group (n = 212) with the following preoperative variables: type of organ transplanted, age, gender, race, body mass index, MELD, redo-transplantation, preoperative renal replacement therapy, nonalcoholic steatohepatitis, viral hepatitis, diabetes, and coronary artery disease...
May 1, 2017: Seminars in Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28481036/generation-and-characterization-of-a-conditional-allele-of-interferon-regulatory-factor-6
#9
Arianna L Smith, Youssef A Kousa, Akira Kinoshita, Kate Fodor, Baoli Yang, Brian C Schutte
Interferon Regulatory Factor 6 (IRF6) is a critical regulator of differentiation, proliferation and migration of keratinocytes. Mutations in IRF6 cause two autosomal dominant disorders characterized by cleft lip with or without cleft palate. In addition, DNA variation in IRF6 confers significant risk for non-syndromic cleft lip and palate. IRF6 is also implicated in adult onset development and disease processes, including mammary gland development and squamous cell carcinoma. Mice homozygous for a null allele of Irf6 die shortly after birth due to severe skin, limb, and craniofacial defects, thus impeding the study of gene function after birth...
May 8, 2017: Genesis: the Journal of Genetics and Development
https://www.readbyqxmd.com/read/28480022/long-term-continental-changes-in-wing-length-but-not-bill-length-of-a-long-distance-migratory-shorebird
#10
David B Lank, Cailin Xu, Brian A Harrington, Richard I Guy Morrison, Cheri L Gratto-Trevor, Peter W Hicklin, Brett K Sandercock, Paul Allen Smith, Eunbi Kwon, Jennie Rausch, Lisa D Pirie Dominix, Diana J Hamilton, Julie Paquet, Sydney E Bliss, Sarah G Neima, Christian Friis, Scott A Flemming, Alexandra M Anderson, Ronald C Ydenberg
We compiled a >50-year record of morphometrics for semipalmated sandpipers (Calidris pusilla), a shorebird species with a Nearctic breeding distribution and intercontinental migration to South America. Our data included >57,000 individuals captured 1972-2015 at five breeding locations and three major stopover sites, plus 139 museum specimens collected in earlier decades. Wing length increased by ca. 1.5 mm (>1%) prior to 1980, followed by a decrease of 3.85 mm (nearly 4%) over the subsequent 35 years...
May 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28463927/population-health-management-is-there-any-role-for-orthopaedics-an-aoa-critical-issues-symposium
#11
Scott D Boden, Brian T Smith, Matthew Handley
The next phase of health-care reform will accelerate the formation of integrated delivery systems and the creation of value and savings through population health management. Accomplishing this goal requires 3 key factors, including (1) enabling groups of physicians and hospitals to legally work together to cover a broad geographic area, (2) the formation of integrated delivery systems that cover the low to high-acuity and post-acute care spectrums, and (3) identifying mechanisms through which a subspecialty can impact the health of a population of patients...
May 3, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28462450/oxidative-stress-contributes-to-status-epilepticus-associated-mortality
#12
Jennifer N Pearson-Smith, Li-Ping Liang, Shane D Rowley, Brian J Day, Manisha Patel
Status epilepticus is a common manifestation of nerve agent toxicity and represents a serious medical emergency with high rates of mortality and neurologic injury in those that survive. The aim of the current study was to determine if targeting oxidative stress with the catalytic antioxidant, AEOL10150, would reduce pilocarpine-induced mortality and attenuate neuronal death and neuroinflammation. We found that treatment with AEOL10150 in conjunction with scopolamine and diazepam following pilocarpine-induced SE was able to significantly reduce mortality compared to treatment with just scopolamine and diazepam...
May 2, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28460689/a-new-4-variable-formula-to-differentiate-normal-variant-st-segment-elevation-in-v2-v4-early-repolarization-from-subtle-left-anterior-descending-coronary-occlusion-adding-qrs-amplitude-of-v2-improves-the-model
#13
Brian E Driver, Ayesha Khalil, Timothy Henry, Faraz Kazmi, Amina Adil, Stephen W Smith
INTRODUCTION: Precordial normal variant ST elevation (NV-STE), previously often called "early repolarization," may be difficult to differentiate from subtle ischemic STE due to left anterior descending (LAD) occlusion. We previously derived and validated a logistic regression formula that was far superior to STE alone for differentiating the two entities on the ECG. The tool uses R-wave amplitude in lead V4 (RAV4), ST elevation at 60 ms after the J-point in lead V3 (STE60V3) and the computerized Bazett-corrected QT interval (QTc-B)...
April 19, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28457346/a-multi-institution-analysis-of-general-surgery-resident-peer-reviewed-publication-trends
#14
Joseph D Forrester, Parswa Ansari, Chandrakanth Are, Edward Auyang, Joseph M Galante, Benjamin T Jarman, Brian R Smith, Anthony C Watkins, Marc L Melcher
BACKGROUND: The process of taking a research project from conception to publication is one way to encourage surgeons to communicate hypothesis, critically assess literature and data, and defend research conclusions to a broad audience. The goal of this study was to define surgery resident publishing epidemiology and identify characteristics of residents and residency programs that might predict increased publication productivity. MATERIALS AND METHODS: A survey was administered to eight general surgery residency programs to collect residency and resident variables from 1993-2013...
April 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28455300/a-case-of-unusual-drug-screening-results
#15
Brian N Chang, Michael P Smith
No abstract text is available yet for this article.
May 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28453837/borrelia-burgdorferi-bbi39-paralogs-targets-of-protective-immunity-reduce-pathogen-persistence-either-in-hosts-or-in-the-vector
#16
Preeti Singh, Deepshikha Verma, Brian T Backstedt, Simarjot Kaur, Manish Kumar, Alexis A Smith, Kavita Sharma, Xiuli Yang, José F Azevedo, Maria Gomes-Solecki, Ozlem Buyuktanir, Utpal Pal
Borrelia burgdorferi genome harbors several paralogous gene families (pgf) that can encode immunogenic proteins of unknown function. Protein-protein interaction assays using a transmission-blocking vaccine candidate, BBA52, as bait identified an interacting partner in spirochetes-a member of pgf 54, annotated as BBI39. We show that BBI39 is a surface-exposed membrane antigen that is immunogenic during spirochete infection, despite the gene being primarily transcribed in the vector with a transient expression in the host only at tick-bite sites...
March 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28452534/first-demonstration-of-electrostatic-damping-of-parametric-instability-at-advanced-ligo
#17
Carl Blair, Slawek Gras, Richard Abbott, Stuart Aston, Joseph Betzwieser, David Blair, Ryan DeRosa, Matthew Evans, Valera Frolov, Peter Fritschel, Hartmut Grote, Terra Hardwick, Jian Liu, Marc Lormand, John Miller, Adam Mullavey, Brian O'Reilly, Chunnong Zhao, B P Abbott, T D Abbott, C Adams, R X Adhikari, S B Anderson, A Ananyeva, S Appert, K Arai, S W Ballmer, D Barker, B Barr, L Barsotti, J Bartlett, I Bartos, J C Batch, A S Bell, G Billingsley, J Birch, S Biscans, C Biwer, R Bork, A F Brooks, G Ciani, F Clara, S T Countryman, M J Cowart, D C Coyne, A Cumming, L Cunningham, K Danzmann, C F Da Silva Costa, E J Daw, D DeBra, R DeSalvo, K L Dooley, S Doravari, J C Driggers, S E Dwyer, A Effler, T Etzel, T M Evans, M Factourovich, H Fair, A Fernández Galiana, R P Fisher, P Fulda, M Fyffe, J A Giaime, K D Giardina, E Goetz, R Goetz, C Gray, K E Gushwa, E K Gustafson, R Gustafson, E D Hall, G Hammond, J Hanks, J Hanson, G M Harry, M C Heintze, A W Heptonstall, J Hough, K Izumi, R Jones, S Kandhasamy, S Karki, M Kasprzack, S Kaufer, K Kawabe, N Kijbunchoo, E J King, P J King, J S Kissel, W Z Korth, G Kuehn, M Landry, B Lantz, N A Lockerbie, A P Lundgren, M MacInnis, D M Macleod, S Márka, Z Márka, A S Markosyan, E Maros, I W Martin, D V Martynov, K Mason, T J Massinger, F Matichard, N Mavalvala, R McCarthy, D E McClelland, S McCormick, G McIntyre, J McIver, G Mendell, E L Merilh, P M Meyers, R Mittleman, G Moreno, G Mueller, J Munch, L K Nuttall, J Oberling, P Oppermann, Richard J Oram, D J Ottaway, H Overmier, J R Palamos, H R Paris, W Parker, A Pele, S Penn, M Phelps, V Pierro, I Pinto, M Principe, L G Prokhorov, O Puncken, V Quetschke, E A Quintero, F J Raab, H Radkins, P Raffai, S Reid, D H Reitze, N A Robertson, J G Rollins, V J Roma, J H Romie, S Rowan, K Ryan, T Sadecki, E J Sanchez, V Sandberg, R L Savage, R M S Schofield, D Sellers, D A Shaddock, T J Shaffer, B Shapiro, P Shawhan, D H Shoemaker, D Sigg, B J J Slagmolen, B Smith, J R Smith, B Sorazu, A Staley, K A Strain, D B Tanner, R Taylor, M Thomas, P Thomas, K A Thorne, E Thrane, C I Torrie, G Traylor, G Vajente, G Valdes, A A van Veggel, A Vecchio, P J Veitch, K Venkateswara, T Vo, C Vorvick, M Walker, R L Ward, J Warner, B Weaver, R Weiss, P Weßels, B Willke, C C Wipf, J Worden, G Wu, H Yamamoto, C C Yancey, Hang Yu, Haocun Yu, L Zhang, M E Zucker, J Zweizig
Interferometric gravitational wave detectors operate with high optical power in their arms in order to achieve high shot-noise limited strain sensitivity. A significant limitation to increasing the optical power is the phenomenon of three-mode parametric instabilities, in which the laser field in the arm cavities is scattered into higher-order optical modes by acoustic modes of the cavity mirrors. The optical modes can further drive the acoustic modes via radiation pressure, potentially producing an exponential buildup...
April 14, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28451620/generalized-joint-hypermobility-is-predictive-of-hip-capsular-thickness
#18
Brian M Devitt, Bjorn N Smith, Robert Stapf, Mark Tacey, John M O'Donnell
BACKGROUND: The pathomechanics of hip microinstability are not clearly defined but are thought to involve anatomical abnormalities, repetitive forces across the hip, and ligamentous laxity. PURPOSE/HYPOTHESIS: The purpose of this study was to explore the relationship between generalized joint hypermobility (GJH) and hip capsular thickness. The hypothesis was that GJH would be predictive of a thin hip capsule. STUDY DESIGN: Cross-sectional study; Level of evidence, 3...
April 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28447624/wireless-power-transfer-to-millimeter-sized-gastrointestinal-electronics-validated-in-a-swine-model
#19
Abubakar Abid, Jonathan M O'Brien, Taylor Bensel, Cody Cleveland, Lucas Booth, Brian R Smith, Robert Langer, Giovanni Traverso
Electronic devices placed in the gastrointestinal (GI) tract for prolonged periods have the potential to transform clinical evaluation and treatment. One challenge to the deployment of such gastroresident electronics is the difficulty in powering millimeter-sized electronics devices without using batteries, which compromise biocompatibility and long-term residence. We examined the feasibility of leveraging mid-field wireless powering to transfer power from outside of the body to electronics at various locations along the GI tract...
April 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28445246/single-delivery-of-high-diversity-fecal-microbiota-preparation-by-colonoscopy-is-safe-and-effective-in-increasing-microbial-diversity-in-active-ulcerative-colitis
#20
Vinita Jacob, Carl Crawford, Shirley Cohen-Mekelburg, Monica Viladomiu, Gregory G Putzel, Yecheskel Schneider, Fatiha Chabouni, Sarah OʼNeil, Brian Bosworth, Viola Woo, Nadim J Ajami, Joseph F Petrosino, Ylaine Gerardin, Zain Kassam, Mark Smith, Iliyan D Iliev, Gregory F Sonnenberg, David Artis, Ellen Scherl, Randy S Longman
BACKGROUND: Recent trials suggest fecal microbiota transplantation (FMT) with repeated enemas and high-diversity FMT donors is a promising treatment to induce remission in ulcerative colitis. METHODS: We designed a prospective, open-label pilot study to assess the safety, clinical efficacy, and microbial engraftment of single FMT delivery by colonoscopy for active ulcerative colitis using a 2-donor fecal microbiota preparation (FMP). Safety and clinical endpoints of response, remission, and mucosal healing at week 4 were assessed...
April 25, 2017: Inflammatory Bowel Diseases
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