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antitetanus immunity

Rachelle L Stammen, Joyce K Cohen, Tracy L Meeker, Maria M Crane, Rama R Amara, Sakeenah L Hicks, Jerrold S Meyer, Kelly F Ethun
Because tetanus can cause significant morbidity and mortality in NHP, colonywide vaccination with tetanus toxoid is recommendedfor outdoor breeding colonies of rhesus macaques, with primary immunizations commonly given to infants at 6 mo of age followed by booster vaccines every 10 y. Maternal antibodies are thought to offer protective immunity to infants younger than 6 mo. However, historical colony data from the Yerkes National Primate Research Center show a higher incidence of tetanus among infants (≤ 6 mo old) born to subordinate dams...
May 15, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
Boushab Mohamed Boushab, Fatim-Zahra Fall-Malick, Mamoudou Savadogo, Leonardo K Basco
Tetanus has become rare in countries with high levels of vaccination coverage and hygiene but may still occur in adults without booster vaccination. In addition to the expanded program on immunization for children and maternal immunization against neonatal tetanus, a systematic vaccination of the population, including boosters, is recommended.
May 2018: Clinical Case Reports
Christian von Hehn, Jonathan Howard, Shifang Liu, Ven Meka, Joe Pultz, Devangi Mehta, Claudia Prada, Soma Ray, Michael R Edwards, Sarah I Sheikh
Objectives: To investigate the immune response to vaccinations in patients with relapsing forms of MS treated with delayed-release dimethyl fumarate (DMF) vs nonpegylated interferon (IFN). Methods: In this open-label, multicenter study, patients received 3 vaccinations: (1) tetanus-diphtheria toxoid (Td) to test T-cell-dependent recall response, (2) pneumococcal vaccine polyvalent to test T-cell-independent humoral response, and (3) meningococcal (groups A, C, W-135, and Y) oligosaccharide CRM197 conjugate to test T-cell-dependent neoantigen response...
January 2018: Neurology® Neuroimmunology & Neuroinflammation
Reginald Gorczynski, Geoffrey Hoffmann
BACKGROUND: The symmetrical immune network theory, developed in 1975, is based on the existence of specific T cell factors and hypothesizes that normal IgG immune responses comprise the production of 2 kinds of antibodies, namely antigen-specific antibodies and anti-idiotypic antibodies. OBJECTIVE: The aim of this study was to confirm the existence of specific T cells factors and to show that immunization of C3H mice with BL/6 skin or using nominal antigen for immunization (Tetanus Toxoid) induced production of antigen-specific (anti-BL/6 or antitetanus) antibodies plus anti-idiotypic antibodies (C3H anti-anti-C3H)...
July 5, 2017: Interactive Journal of Medical Research
Çiğdem Kader, Mehmet Balci, Ayşe Erbay
BACKGROUND/AIM: To assess the immune status against tetanus in relation to self-declared vaccination status among an adult population in Yozgat, Turkey. METHODS: Questionnaires and blood specimens were collected from 267 individuals over 18 years of age in Yozgat, Turkey. Antitetanus antibodies were determined quantitatively by enzyme-linked immunosorbent assay. RESULTS: Among the 267 subjects (mean age 43.4 ± 15.6; male:female, 133:134) 168 (62...
2016: Turkish Journal of Medical Sciences
Ray Borrow, Yuxiao Tang, Ahmadu Yakubu, Prasad S Kulkarni, F Marc LaForce
BACKGROUND: The group A meningococcal conjugate vaccine, PsA-TT, uses tetanus toxoid (TT) as a carrier protein (PsA-TT). TT as a carrier protein in other conjugate vaccines is known to be immunogenic and generates a robust anti-TT response. METHODS: Clinical studies in Africa assessed whether PsA-TT generated tetanus serologic responses when tested in African populations (toddlers to adults). Second, the high acceptance of PsA-TT mass immunization campaigns in the 1- to 29-year age group meant that a sizeable fraction of women of reproductive age received PsA-TT...
November 15, 2015: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Isabel Garcia de la Fuente, Noémie Wagner, Claire-Anne Siegrist, Klara M Posfay-Barbe
BACKGROUND: Data on vaccination coverage in recently arrived refugee children are essential to formulate catch-up recommendations. "Overimmunizing" is costly and associated with risks of hyperimmunization, whereas assuming up-to-date immunizations may be misleading. METHODS: We retrospectively collected data from 92 migrant children referred to our hospital between January 2009 and May 2010. RESULTS: According to our guidelines, 68 (73.9%) children without evidence of up-to-date immunizations received a booster dose of an age-appropriate tetanus-containing vaccine...
March 2013: Pediatric Infectious Disease Journal
Christian Pötschke, Sixten Selleng, Barbara M Bröker, Andreas Greinacher
Cardiopulmonary bypass surgery (CPB) is associated with a high incidence of IgG Abs against platelet factor 4/heparin (PF4/H) complexes by day 6 after surgery. These Abs are associated with an immune-mediated adverse drug reaction, heparin-induced thrombocytopenia. Although the early onset of the anti-PF4/H IgG response is compatible with a secondary immune response, the rapid decline of Ab titers thereafter is not. To shed light on the origin of these Abs, in the present study, we prospectively compared the kinetics of these Abs with that of Abs against 2 recall Ags and to that of autoantibodies in 166 CPB patients over 4 months...
November 15, 2012: Blood
J Carbone, E Sarmiento, N Del Pozo, J J Rodriguez-Molina, J Navarro, J Fernandez-Yañez, J Palomo, A Villa, P Muñoz, E Fernandez-Cruz
IgG hypogammaglobulinemia is a risk factor for infection in heart recipients. We assessed reconstitution of humoral immunity after non-specific intravenous immunoglobulin (IVIg) replacement therapy administered to treat secondary IgG hypogammaglobulinemia in heart recipients with severe infections. The study population comprised 55 heart recipients who were administered IVIg (IVIg group) and 55 heart recipients with no severe infectious complications (control group). An event was defined as a severe infection requiring intravenous drug therapy during the first year after transplantation...
May 2012: Clinical Transplantation
A A Savis'ko, G G Kharseeva, E P Moskalenko
To define the likelihood of development of adverse reactions and complications due to vaccination, the authors conducted clinical and laboratory studies of 115 children aged 1 to 15 years with chronic pathology (allergic diseases, pyelonephritis, immunodeficiency states), vaccinated with diphtheria and tetanus toxoids and pertussis vaccine and diphtheria and tetanus-M anatoxin and revaccinated with diphtheria and tetanus-M anatoxin. The results of the study suggested the prognostic value of allergic reaction indicators (total IgE, DA- and CA-specific IgE, vaccine sensitization detected by the basophil degranulation test) against adverse events and complications of immunization...
February 2011: Klinicheskaia Laboratornaia Diagnostika
Christine E Jones, Shalena Naidoo, Corena De Beer, Monika Esser, Beate Kampmann, Anneke C Hesseling
CONTEXT: Altered immune responses might contribute to the high morbidity and mortality observed in human immunodeficiency virus (HIV)-exposed uninfected infants. OBJECTIVE: To study the association of maternal HIV infection with maternal- and infant-specific antibody levels to Haemophilus influenzae type b (Hib), pneumococcus, Bordetella pertussis antigens, tetanus toxoid, and hepatitis B surface antigen. DESIGN, SETTING, AND PARTICIPANTS: A community-based cohort study in Khayelitsha, Western Cape Province, South Africa, between March 3, 2009, and April 28, 2010, of 109 HIV-infected and uninfected women and their infants...
February 9, 2011: JAMA: the Journal of the American Medical Association
Zoran Golubovic, Predrag Stojiljković, Milorad Mitković, Srbobran Trenkić, Zoran Vukasinović, Aleksandar Lesic, Milomir Kosutić, Dragan Milić, Stevo Najman, Ivan Golubović, Aleksandar Visnjić
INTRODUCTION: Aircraft cluster bombs can cause severe fractures characterized by extensive destruction of affected tissues and organs. CASE OUTLINE: We present the methods and results of treatment of multiple fractures (left supracondilar humeral fracture, comminuted fracture of the distal right tibia, fracture of right trochanter major without dislocation and fracture of the right second metacarpal bone) in a 24-year old soldier after multiple wounding by a cluster bomb...
May 2010: Srpski Arhiv za Celokupno Lekarstvo
Clifton O Bingham, R John Looney, Atul Deodhar, Neal Halsey, Maria Greenwald, Christine Codding, Benjamin Trzaskoma, Flavius Martin, Sunil Agarwal, Ariella Kelman
OBJECTIVE: To examine immunization responses in patients with rheumatoid arthritis (RA) treated with rituximab and to investigate the effects of rituximab-induced CD20+ B cell depletion on immune responses to tetanus toxoid (T cell-dependent antigen), pneumococcal polysaccharide (T cell-independent antigen), and keyhole limpet hemocyanin (KLH) (neoantigen) and on delayed-type hypersensitivity (DTH). METHODS: In a controlled trial, we enrolled 103 patients with active RA receiving a stable dose of methotrexate (MTX)...
January 2010: Arthritis and Rheumatism
Mohammad Mahdi Sagheb, Sharareh Sajjadi, Golmehr Sajjady
Patients with end stage renal disease suffer from a high incidence of infectious diseases believed to be related to their impaired immune system. To determine the antitetanus and antidiphtheria IgG antibody levels in Iranian hemodialysis patients with end stage renal disease, as well as its association with sex, age, hemoglobin, zinc serum level, serum albumin, duration of dialysis, number of dialysis per week, dialysis adequacy, erythropoietin or iron supplements such as venofer, body mass index (BMI), and underlying renal disorder, we conducted a cross-sectional study on a total of 112 hemodialysis patients with end stage renal disorder (60 male, 52 female ) and 36 healthy individuals in the control group (14 male, 22 female)...
2009: Renal Failure
Dennis R Ownby, Megan E Partridge, Ganesa R Wegienka, Kimberley J Woodcroft, Edward L Peterson, Christine L M Joseph, L Keoki Williams, Christine C Johnson
BACKGROUND: Previous studies suggest that small antigen doses given frequently are more likely to induce IgE production than are large antigen doses given infrequently. OBJECTIVE: To compare the prevalence of antitetanus IgE resulting from the relatively large dose of tetanus toxoid delivered by standard immunizations at 2, 4, 6, and 18 months of age with the previously reported prevalence of anti-fire ant venom IgE resulting from the relatively small dose of venom delivered sporadically by accidental fire ant stings in children younger than 5 years...
October 2009: Annals of Allergy, Asthma & Immunology
Mutsumi Fujii, Mitsuhiko Hokari, Akiko Yokoyama, Hiroki Miyashita, Akiko Ishihara, Taro Fujikawa
A 77-year-old man non-immunized to tetanus suffered head trauma on the right side when he tumbled from a height of approximately 2m. Five days later, he experienced difficulty in opening his mouth and developed right ptosis. He was referred to our hospital 2 days post-ictus. The patient suffered trismus, and developed right Horner's syndrome with in a week. Symptoms due to multiple cranial nerve palsies were observed: right inferior oblique muscle weakness, reduced right corneal reflex, right facial palsy, dysphagia, and abnormal tongue movements...
August 2009: Brain and Nerve, Shinkei Kenkyū No Shinpo
Elham Hossny, Hanaa El-Awady, Mervat El-Feky, Rasha El-Owaidy
BACKGROUND: Primary immunodeficiency diseases are underdiagnosed in developing countries. The aim of this study was to identify primary B- and T-cell immune defects in Egyptian infants and children with clinical criteria indicating primary immunodeficiency disease. MATERIAL/METHODS: We enrolled 100 consecutive infants and children clinically suspected to have primary immunodeficiency disease. Subjects were evaluated with respect to immunodeficiency-related score, complete blood count, erythrocyte sedimentation rate, serum immunoglobulin (Ig) A and tetanus IgG antibody estimation, and Candida and tuberculin intradermal testing...
May 2009: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Markus Knuf, Leszek Szenborn, Masnuel Moro, Christian Petit, Nancy Bermal, Laurence Bernard, Ilse Dieussaert, Lode Schuerman
BACKGROUND: The choice of non-typeable Haemophilus influenzae Protein D as main carrier protein in the candidate 10-valent pneumococcal conjugate vaccine (PHiD-CV, GlaxoSmithKline Biologicals), was driven in part to avoid carrier-mediated suppression and possible bystander interference with coadministered vaccines. Immunogenicity data from 3 primary and 2 booster vaccination studies were assessed for possible impacts of PHiD-CV coadministration on immune responses to routinely administered childhood vaccines, in comparison to 7-valent pneumococcal conjugate vaccine (7vCRM) coadministration...
April 2009: Pediatric Infectious Disease Journal
Mohammed-Jafar Saffar, Ali-Rezas Khalilian, Abolghasem Ajami, Hiva Saffar, Abbas Qaheri
BACKGROUND: This study was designed to determine the levels of immunity against diphtheria and tetanus in 110 mothers with/without diphtheria-tetanus toxoid (dT) vaccination during pregnancy and their two-month-old infants before diphtheria-tetanus-pertussis (DTP) immunisation, and also to assess the influence of pre-vaccination passive immunity on the infants' immune response to three doses of DTP vaccination. SUBJECTS AND METHODS: Sera from 110 mother-infant pairs before DTP vaccination and from 69 infants after receipt of three doses of DTP vaccine were tested to measure antidiphtheria-antitetanus toxin IgG levels, using a commercial enzyme immunoassay...
May 3, 2008: Swiss Medical Weekly
Emanuela Turillazzi, Margherita Neri, Cristoforo Pomara, Irene Riezzo, Vittorio Fineschi
A 65-year-old man fell in his garden and sustained a right pre-radial cutaneous laceration associated with a Colles' fracture. His status for tetanus immunization was uncertain; so a course of antitetanus treatment was immediately started. Two days after admission the man suddenly developed severe nucal pain, rigidity and dysphagia. A brain CT scan was negative. His condition progressively worsened and then he developed trismus. Cultures from the wound were negative for Clostridium tetani; the CSF analysis was negative...
February 2009: Neuropathology: Official Journal of the Japanese Society of Neuropathology
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