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https://www.readbyqxmd.com/read/29621739/incidence-of-hypersensitivity-and-anaphylaxis-with-sugammadex
#1
K Chris Min, Tiffany Woo, Christopher Assaid, Jacqueline McCrea, Deborah M Gurner, Christine McCrary Sisk, Franklin Adkinson, W Joseph Herring
STUDY OBJECTIVE: To evaluate the incidence of hypersensitivity and anaphylaxis after administration of sugammadex. DESIGN: Retrospective analysis. SETTING: Sugammadex clinical development program and post-marketing experience. PATIENTS: Surgical patients and healthy volunteers who received sugammadex or placebo/comparator with anesthesia and/or neuromuscular blockade (NMB). INTERVENTIONS: Sugammadex administered as 2...
April 2, 2018: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/29605039/activation-of-mammalian-target-of-rapamycin-induces-lipid-accumulation-in-the-diaphragm-of-ventilated-rats-and-hypoxia-treated-c2c12-cells
#2
Tao Yu, Mengli Wang, Yadong Wen, Yingya Cao, Guanggui Shen, Xiaogan Jiang, Jingyi Wu, Weihua Lu, Xiaoju Jin
BACKGROUND: Our previous study demonstrated that ventilators increase diaphragmatic lipid accumulation in rabbits, but their cellular mechanism is poorly understood. Mammalian target of rapamycin (mTOR) plays an important role in atherosclerosis in rat vascular smooth muscle cells. The present study investigated the role of mTOR pathway activation in the diaphragmatic muscle of ventilated rats and hypoxia-induced C2C12 cells. MATERIALS AND METHODS: Male Sprague-Dawly rats were randomized into a control group (n = 8), controlled mechanical ventilation (CMV) group (n = 8), and CMV + Rapa group (n = 8)...
May 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29509579/does-equi-minimum-alveolar-concentration-value-ensure-equivalent-analgesic-or-hypnotic-potency-a-comparison-between-desflurane-and-sevoflurane
#3
Kyoung-Ho Ryu, Keulame Song, Tae-Young Lim, Won-Jun Choi, Yun-Hong Kim, Hyun-Soo Kim
BACKGROUND: Minimum alveolar concentration (MAC) has traditionally been used to compare the potency of volatile anesthetics. However, as it reflects the spinal mechanism of immobility rather than the cerebral mechanism of analgesia and hypnosis, it is doubtful that equi-MAC connotes equivalent analgesic or hypnotic potency. The level of analgesia and hypnosis can be assessed using surgical pleth index and bispectral index (BIS) values, respectively. This study was designed to compare the surgical pleth index and BIS values produced by equi-MAC of desflurane and sevoflurane in patients undergoing single-agent volatile anesthesia...
March 6, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29476695/morphological-and-functional-analyses-of-skeletal-muscles-from-an-immunodeficient-animal-model-of-limb-girdle-muscular-dystrophy-type-2e
#4
Gaia Giovannelli, Giorgia Giacomazzi, Hanne Grosemans, Maurilio Sampaolesi
Introduction - Limb-girdle muscular dystrophy type 2E (LGMD 2E) is caused by mutations in the β-sarcoglycan gene, which is expressed in skeletal, cardiac and smooth muscle. β-sarcoglycan deficient (Sgcb-null) mice develop severe muscular dystrophy and cardiomyopathy with focal areas of necrosis. Methods - We performed morphological (histological and cellular characterization) and functional (isometric tetanic force and fatigue) analyses in dystrophic mice. Comparisons studies were carried out in 1-month-old (clinical onset of the disease) and 7-month-old mice among controls (C57/BL6, Rag2/γc-null), immunocompetent and immunodeficient dystrophic mice (Sgcb-null, Sgcb/Rag2/γc-null mice respectively)...
February 24, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29474954/orexin-1-and-orexin-2-receptor-antagonism-in-the-basolateral-amygdala-modulate-long-term-potentiation-of-the-population-spike-in-the-perforant-path-dentate-gyrus-evoked-field-potential-in-rats
#5
Motahareh Rouhi Ardeshiri, Narges Hosseinmardi, Esmaeil Akbari
Involvement of amygdalo-hippocampal substructures in patients with narcolepsy due to deficiencies in the orexinergic system, and the presence of hippocampus-dependent memory impairments in this disorder, have led us to investigate the effects of orexin 1 and 2 receptor antagonism in the basolateral amygdala (BLA) on long-term potentiation (LTP) of dentate gyrus (DG) granular cells. We used a 200-Hz high-frequency stimulation protocol in anesthetized rats. We studied the long-term synaptic plasticity of perforant path-dentate gyrus granule cells following the inactivation of orexin receptors before and after tetanic stimulation...
March 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29452288/repetitive-tlr-3-activation-in-the-lung-induces-skeletal-muscle-adaptations-and-cachexia
#6
Ted G Graber, Brandy L Rawls, Bing Tian, William J Durham, Camille R Brightwell, Allan R Brasier, Blake B Rasmussen, Christopher S Fry
Due to immunosenescence, older adults are particularly susceptible to lung-based viral infections, with increased severity of symptoms in those with underlying chronic lung disease. Repeated respiratory viral infections produce lung maladaptations, accelerating pulmonary dysfunction. Toll like 3 receptor (TLR3) is a membrane protein that senses exogenous double-stranded RNA to activate the innate immune response to a viral infection. Polyinosinic-polycytidylic acid [poly(I:C)] mimics double stranded RNA and has been shown to activate TLR3...
February 13, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29451212/is-it-necessary-to-use-the-entire-root-as-a-donor-when-transferring-contralateral-c-7-nerve-to-repair-median-nerve
#7
Kai-Ming Gao, Jie Lao, Wen-Jie Guan, Jing-Jing Hu
If a partial contralateral C 7 nerve is transferred to a recipient injured nerve, results are not satisfactory. However, if an entire contralateral C 7 nerve is used to repair two nerves, both recipient nerves show good recovery. These findings seem contradictory, as the above two methods use the same donor nerve, only the cutting method of the contralateral C 7 nerve is different. To verify whether this can actually result in different repair effects, we divided rats with right total brachial plexus injury into three groups...
January 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29411483/extraocular-muscle-architecture-in-hawks-and-owls
#8
Jeffrey H Plochocki, Tamar Segev, Wade Grow, Margaret I Hall
OBJECTIVE: A complete and accurate understanding of extraocular muscle function is important to the veterinary care of the avian eye. This is especially true for birds of prey, which rely heavily on vision for survival and yet are prone to ocular injury and disease. To better understand the function of extraocular muscles in birds of prey, we studied extraocular muscle architecture grossly and histologically. ANIMALS STUDIED: This sample was composed of two each of the following species: red-tailed hawk (Buteo jamaicensis), Harris's hawk (Parabuteo unicinctus), great horned owl (Bubo virginianus), and barn owl (Tyto alba)...
February 6, 2018: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29329332/co-delivery-of-a-laminin-111-supplemented-hyaluronic-acid-based-hydrogel-with-minced-muscle-graft-in-the-treatment-of-volumetric-muscle-loss-injury
#9
Stephen M Goldman, Beth E P Henderson, Thomas J Walters, Benjamin T Corona
Minced muscle autografting mediates de novo myofiber regeneration and promotes partial recovery of neuromuscular strength after volumetric muscle loss injury (VML). A major limitation of this approach is the availability of sufficient donor tissue for the treatment of relatively large VMLs without inducing donor site morbidity. This study evaluated a laminin-111 supplemented hyaluronic acid based hydrogel (HA+LMN) as a putative myoconductive scaffolding to be co-delivered with minced muscle grafts. In a rat tibialis anterior muscle VML model, delivery of a reduced dose of minced muscle graft (50% of VML defect) within HA+LMN resulted in a 42% improvement of peak tetanic torque production over unrepaired VML affected limbs...
2018: PloS One
https://www.readbyqxmd.com/read/29305235/validation-of-isometric-tetanic-force-as-a-measure-of-muscle-recovery-after-nerve-injury-in-the-rabbit-biceps
#10
Kathleen M Kollitz, Guilherme Giusti, Patricia F Friedrich, Allen T Bishop, Alexander Y Shin
PURPOSE: The purpose of this study was to describe and validate a technique for measurement of isometric tetanic force (ITF) in the rabbit biceps muscle. MATERIALS AND METHODS: Eighteen New Zealand White rabbits were randomized to test either the right side or the left side first. Under propofol anesthesia, the brachial plexus and biceps brachii were exposed. The middle trunk (C6, C7) was secured in a bipolar electrode. Compound muscle action potential (CMAP) was measured...
January 3, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29297989/increased-temperature-accelerates-glycogen-synthesis-and-delays-fatigue-in-isolated-mouse-muscle-during-repeated-contractions
#11
E Hanya, A Katz
AIM: Elevated glycogen content in muscle delays fatigue during exercise. We examined if increasing muscle temperature during recovery from exercise affects glycogen synthesis and muscle performance during a subsequent bout of exercise. METHODS: Isolated mouse extensor digitorum longus muscles were stimulated electrically to perform repeated tetanic contractions until force decreased to 40% of initial at 25°C. Thereafter, muscles recovered for 120 minutes at 25°C (control), 120 minutes at 35°C or 60 minutes at 35°C followed by 60 minutes at 25°C...
January 3, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29280493/the-effects-of-concurrent-chemoradiation-therapy-to-the-base-of-tongue-in-a-preclinical-model
#12
Peter A Benedict, Ryan Ruiz, Avanti Verma, Gregory R Dion, Philmo Oh, Binhuan Wang, Omar H Ahmed, Nao Hiwatashi, Renjie Bing, Kristen Victor, Kenneth S Hu, Aaron Johnson, Ryan C Branski, Milan R Amin
OBJECTIVES/HYPOTHESIS: To develop a clinically relevant model of oropharyngeal concurrent chemoradiation therapy (CCRT) in order to quantify the effects of CCRT on tongue function and structure. CCRT for advanced oropharyngeal cancer commonly leads to tongue base dysfunction and dysphagia. However, no preclinical models currently exist to study the pathophysiology of CCRT-related morbidity, thereby inhibiting the development of targeted therapeutics. STUDY DESIGN: Animal model...
December 27, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29280475/the-comparative-efficacy-and-safety-of-sugammadex-and-neostigmine-in-reversing-neuromuscular-blockade-in-adults-a-cochrane-systematic-review-with-meta-analysis-and-trial-sequential-analysis
#13
REVIEW
A-M Hristovska, P Duch, M Allingstrup, A Afshari
We compared the efficacy and safety of sugammadex and neostigmine in reversing neuromuscular blockade in adults. Our outcomes were: recovery time from second twitch to train-of-four ratio > 0.9; recovery time from post-tetanic count 1-5 to train-of-four ratio > 0.9; and risk of composite adverse and serious adverse events. We searched for randomised clinical trials irrespective of publication status and date, blinding status, outcomes reported or language. We included 41 studies with 4206 participants...
December 27, 2017: Anaesthesia
https://www.readbyqxmd.com/read/29239154/neuromuscular-block-in-laparoscopic-surgery
#14
Thomas Fuchs-Buder, Edoardo DE Robertis, Laurent Brunaud
BACKGROUND: There is an increased interest in the current literature to evaluate the potential clinical benefit of a sustained deep neuromuscular blockade ( i.e. a post-tetanic count ≤ 3) during various laparoscopic surgical procedures. This deep block concept represents a new area of clinical research, which concerns both, anesthesiologists and surgeons. METHODS: We reviewed a selection of recent publications about the indications and the potential benefits of a maintained deep neuromuscular blockade during different laparoscopic procedures...
December 13, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29238473/the-effects-of-cck-8s-on-spatial-memory-and-long-term-potentiation-at-ca1-during-induction-of-stress-in-rats
#15
Malihe Sadeghi, Parham Reisi, Maryam Radahmadi
Objectives: Cholecystokinin (CCK) has been proposed as a mediator in stress. However, it is still not fully documented what are its effects. We aimed to evaluate the effects of systemic administration of CCK exactly before induction of stress on spatial memory and synaptic plasticity at CA1 in rats. Materials and Methods: Male Wistar rats were divided into 4 groups: the control, the control-CCK, the stress and the stress-CCK. Restraint stress was induced 6 hr per day, for 24 days...
December 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29189318/standardised-noxious-stimulation-guided-individual-adjustment-of-remifentanil-target-controlled-infusion-to-prevent-haemodynamic-responses-to-laryngoscopy-and-surgical-incision-a-randomised-controlled-trial
#16
Aline Defresne, Luc Barvais, François Clement, Vincent Bonhomme
BACKGROUND: The surgical plethysmographic index (SPI) is one of the available indexes of the nociception-antinociception (NAN) balance. Individually adjusting the NAN balance to prevent somatic responses to noxious stimulation remains a challenge. OBJECTIVES: To assess whether guiding remifentanil administration according to the SPI response to a calibrated noxious stimulus (NANCAL) can blunt the haemodynamic response to tracheal intubation and surgical incision...
March 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29186696/a-highly-sensitive-fret-biosensor-for-ampk-exhibits-heterogeneous-ampk-responses-among-cells-and-organs
#17
Yumi Konagaya, Kenta Terai, Yusuke Hirao, Kanako Takakura, Masamichi Imajo, Yuji Kamioka, Norio Sasaoka, Akira Kakizuka, Kenta Sumiyama, Tomoichiro Asano, Michiyuki Matsuda
AMP-activated protein kinase (AMPK), a master regulator of cellular metabolism, is a potential target for type 2 diabetes. Although extensive in vitro studies have revealed the complex regulation of AMPK, much remains unknown about the regulation in vivo. We therefore developed transgenic mice expressing a highly sensitive fluorescence resonance energy transfer (FRET)-based biosensor for AMPK, called AMPKAR-EV. AMPKAR-EV allowed us to readily examine the role of LKB1, a canonical stimulator of AMPK, in drug-induced activation and inactivation of AMPK in vitro...
November 28, 2017: Cell Reports
https://www.readbyqxmd.com/read/29182615/effects-of-individual-stressors-used-in-a-battery-of-chronic-unpredictable-stress-on-long-term-plasticity-in-the-hippocampus-of-juvenile-rats
#18
Alexandra A Gorbunova, Irina V Kudryashova, Anna O Manolova, Margarita R Novikova, Mikhail Yu Stepanichev, Natalia V Gulyaeva
We have studied alterations in the properties of long-term potentiation (LTP) in hippocampal slices of juvenile rats induced by the exposure of animals to different individual stressors usually used in batteries of chronic unpredictable stress (CUS), a widely used model of depression. Social isolation for 16 h did substantially affect neither the magnitude and nor the development of LTP. The effects of stroboscopic illumination and water deprivation appeared most severe, though opposite: the first stressor had activating effect, whereas the second one inhibited the development of LTP...
2017: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/29178460/the-adequate-rocuronium-dose-required-for-complete-block-of-the-adductor-muscles-of-the-thigh
#19
M Fujimoto, K Kawano, T Yamamoto
BACKGROUND: Rocuronium can prevent the obturator jerk during transurethral resection of bladder tumors. We investigated the adequate rocuronium dose required for complete block of the thigh adductor muscles, and its correlation with individual responses of the adductor pollicis muscle to rocuronium. METHODS: Eleven patients scheduled for transurethral resection of bladder tumors under general anesthesia were investigated. After general anesthesia induction, neuromuscular monitoring of the adductor pollicis muscle and ultrasonography-guided stimulation of the obturator nerve was commenced...
March 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29162949/neuromuscular-electrical-stimulation-for-treatment-of-muscle-impairment-critical-review-and-recommendations-for-clinical-practice
#20
Ethne L Nussbaum, Pamela Houghton, Joseph Anthony, Sandy Rennie, Barbara L Shay, Alison M Hoens
Purpose: In response to requests from physiotherapists for guidance on optimal stimulation of muscle using neuromuscular electrical stimulation (NMES), a review, synthesis, and extraction of key data from the literature was undertaken by six Canadian physical therapy (PT) educators, clinicians, and researchers in the field of electrophysical agents. The objective was to identify commonly treated conditions for which there was a substantial body of literature from which to draw conclusions regarding the effectiveness of NMES...
2017: Physiotherapy Canada. Physiothérapie Canada
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