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potassium new england journal medicine

Michelle L Gumz, Lawrence Rabinowitz, Charles S Wingo
New England Journal of Medicine, Volume 373, Issue 1, Page 60-72, July 2015.
July 2, 2015: New England Journal of Medicine
Mark A Knepper, Tae-Hwan Kwon, Soren Nielsen
New England Journal of Medicine, Volume 372, Issue 14, Page 1349-1358, April 2015.
April 2, 2015: New England Journal of Medicine
Ewout J Hoorn
This commentary discusses two recent publications by Weir et al. and Packham et al. in The New England Journal of Medicine on the efficacy of two novel potassium binders, sodium zirconium cyclosilicate and patiromer. In a similar manner to existing potassium binders, these drugs exchange dietary potassium for either sodium or calcium in the gut, thereby preventing absorption of potassium. Both drugs were tested against placebo in patients with chronic kidney disease who developed hyperkalaemia because they were also using renin-angiotensin-aldosterone system (RAAS) inhibitors...
2015: Nederlands Tijdschrift Voor Geneeskunde
David K Packham, Henrik S Rasmussen, Philip T Lavin, Mohamed A El-Shahawy, Simon D Roger, Geoffrey Block, Wajeh Qunibi, Pablo Pergola, Bhupinder Singh
BACKGROUND: Hyperkalemia (serum potassium level, >5.0 mmol per liter) is associated with increased mortality among patients with heart failure, chronic kidney disease, or diabetes. We investigated whether sodium zirconium cyclosilicate (ZS-9), a novel selective cation exchanger, could lower serum potassium levels in patients with hyperkalemia. METHODS: In this multicenter, two-stage, double-blind, phase 3 trial, we randomly assigned 753 patients with hyperkalemia to receive either ZS-9 (at a dose of 1...
January 15, 2015: New England Journal of Medicine
Matthew R Weir, George L Bakris, David A Bushinsky, Martha R Mayo, Dahlia Garza, Yuri Stasiv, Janet Wittes, Heidi Christ-Schmidt, Lance Berman, Bertram Pitt
BACKGROUND: Hyperkalemia increases the risk of death and limits the use of inhibitors of the renin-angiotensin-aldosterone system (RAAS) in high-risk patients. We assessed the safety and efficacy of patiromer, a nonabsorbed potassium binder, in a multicenter, prospective trial. METHODS: Patients with chronic kidney disease who were receiving RAAS inhibitors and who had serum potassium levels of 5.1 to less than 6.5 mmol per liter received patiromer (at an initial dose of 4...
January 15, 2015: New England Journal of Medicine
Nicholas I Paton, Cissy Kityo, Anne Hoppe, Andrew Reid, Andrew Kambugu, Abbas Lugemwa, Joep J van Oosterhout, Mary Kiconco, Abraham Siika, Raymond Mwebaze, Mary Abwola, George Abongomera, Aggrey Mweemba, Hillary Alima, Dickens Atwongyeire, Rose Nyirenda, Justine Boles, Jennifer Thompson, Dinah Tumukunde, Ennie Chidziva, Ivan Mambule, Jose R Arribas, Philippa J Easterbrook, James Hakim, A Sarah Walker, Peter Mugyenyi
BACKGROUND: The efficacy and toxic effects of nucleoside reverse-transcriptase inhibitors (NRTIs) are uncertain when these agents are used with a protease inhibitor in second-line therapy for human immunodeficiency virus (HIV) infection in resource-limited settings. Removing the NRTIs or replacing them with raltegravir may provide a benefit. METHODS: In this open-label trial in sub-Saharan Africa, we randomly assigned 1277 adults and adolescents with HIV infection and first-line treatment failure to receive a ritonavir-boosted protease inhibitor (lopinavir-ritonavir) plus clinician-selected NRTIs (NRTI group, 426 patients), a protease inhibitor plus raltegravir in a superiority comparison (raltegravir group, 433 patients), or protease-inhibitor monotherapy after 12 weeks of induction therapy with raltegravir in a noninferiority comparison (monotherapy group, 418 patients)...
July 17, 2014: New England Journal of Medicine
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