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https://www.readbyqxmd.com/read/28231402/ex-vivo-visualization-of-human-ciliated-epithelium-and-quantitative-analysis-of-induced-flow-dynamics-by-using-optical-coherence-tomography
#1
Yuye Ling, Xinwen Yao, Ute A Gamm, Emilio Arteaga-Solis, Charles W Emala, Michael A Choma, Christine P Hendon
BACKGROUND AND OBJECTIVE: Cilia-driven mucociliary clearance is an important self-defense mechanism of great clinical importance in pulmonary research. Conventional light microscopy possesses the capability to visualize individual cilia and its beating pattern but lacks the throughput to assess the global ciliary activities and flow dynamics. Optical coherence tomography (OCT), which provides depth-resolved cross-sectional images, was recently introduced to this area. MATERIALS AND METHODS: Fourteen de-identified human tracheobronchial tissues are directly imaged by two OCT systems: one system centered at 1,300 nm with 6...
February 23, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28231235/near-real-time-surveillance-of-u-s-norovirus-outbreaks-by-the-norovirus-sentinel-testing-and-tracking-network-united-states-august-2009-july-2015
#2
Minesh P Shah, Mary E Wikswo, Leslie Barclay, Anita Kambhampati, Kayoko Shioda, Umesh D Parashar, Jan Vinjé, Aron J Hall
Norovirus is the leading cause of endemic and epidemic acute gastroenteritis in the United States (1). New variant strains of norovirus GII.4 emerge every 2-4 years (2-4) and are often associated with increased disease and health care visits (5-7). Since 2009, CDC has obtained epidemiologic data on norovirus outbreaks from state health departments through the National Outbreak Reporting System (NORS) (8) and laboratory data through CaliciNet (9). NORS is a web-based platform for reporting waterborne, foodborne, and enteric disease outbreaks of all etiologies, including norovirus, to CDC...
February 24, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28228492/neisseria-gonorrhoeae-sequence-typing-for-antimicrobial-resistance-ng-star-a-novel-antimicrobial-resistance-multilocus-typing-scheme-for-tracking-the-global-dissemination-of-n-gonorrhoeae-strains
#3
W Demczuk, S Sidhu, M Unemo, D M Whiley, V G Allen, J R Dillon, M Cole, C Seah, E Trembizki, D L Trees, E N Kersh, A J Abrams, H J C de Vries, A P van Dam, I Medina, A Bharat, M R Mulvey, G Van Domselaar, I Martin
A curated web-based user-friendly sequence typing tool based on antimicrobial resistance determinants in Neisseria gonorrhoeae was developed and is publicly accessible at https://ngstar.canada.ca The N. gonorrhoeae Sequence Typing for Antimicrobial Resistance (NG-STAR) molecular typing scheme uses the DNA sequences of 7 genes (penA, mtrR, porB, ponA, gyrA, parC, 23S rRNA) associated with resistance to β-lactam antimicrobials, macrolides, or fluoroquinolones. NG-STAR uses the entire penA sequence combining the historical nomenclature for penA types I-XXXVIII with novel nucleotide sequence designations; the full mtrR sequence and a portion of its promoter region; portions of ponA, porB, gyrA and parC; and 23S rRNA sequences...
February 22, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28227956/a-wirelessly-powered-homecage-with-animal-behavior-analysis-and-closed-loop-power-control
#4
Yaoyao Jia, Zheyuan Wang, Daniel Canales, Morgan Tinkler, Chia-Chun Hsu, Teresa E Madsen, S Abdollah Mirbozorgi, Donald Rainnie, Maysam Ghovanloo, Yaoyao Jia, Zheyuan Wang, Daniel Canales, Morgan Tinkler, Chia-Chun Hsu, Teresa E Madsen, S Abdollah Mirbozorgi, Donald Rainnie, Maysam Ghovanloo, Donald Rainnie, Chia-Chun Hsu, Teresa E Madsen, Morgan Tinkler, Daniel Canales, Zheyuan Wang, S Abdollah Mirbozorgi, Maysam Ghovanloo, Yaoyao Jia
This paper presents a new EnerCage-homecage system, EnerCage-HC2, for longitudinal electrophysiology data acquisition experiments on small freely moving animal subjects, such as rodents. EnerCage-HC2 is equipped with multi-coil wireless power transmission (WPT), closed-loop power control, bidirectional data communication via Bluetooth Low Energy (BLE), and Microsoft Kinect® based animal behavior tracking and analysis. The EnerCage-HC2 achieves a homogeneous power transfer efficiency (PTE) of 14% on average, with ~42 mW power delivered to the load (PDL) at a nominal height of 7 cm by the closed-loop power control mechanism...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227942/unified-phase-variables-of-relative-degree-two-for-human-locomotion
#5
Dario J Villarreal, Robert D Gregg, Dario J Villarreal, Robert D Gregg, Robert D Gregg, Dario J Villarreal
A starting point to achieve stable locomotion is synchronizing the leg joint kinematics during the gait cycle. Some biped robots parameterize a nonlinear controller (e.g., input-output feedback linearization) whose main objective is to track specific kinematic trajectories as a function of a single mechanical variable (i.e., a phase variable) in order to allow the robot to walk. A phase variable capable of parameterizing the entire gait cycle, the hip phase angle, has been used to control wearable robots and was recently shown to provide a robust representation of the phase of human gait...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227597/long-term-vital-sign-measurement-using-a-non-contact-vital-sign-sensor-inside-an-office-cubicle-setting
#6
T Hall, N A Malone, J Tsay, J Lopez, T Nguyen, R E Banister, D Y C Lie, T Hall, N A Malone, J Tsay, J Lopez, T Nguyen, R E Banister, D Y C Lie, T Hall, J Lopez, N A Malone, T Nguyen, J Tsay, D Y C Lie, R E Banister
Heart and respiration rates can be wirelessly measured by extracting the phase shift caused by the periodic displacement of a patient's chest wall. We have developed a phased-array Doppler-based non-contact vital sign (NCVS) sensor capable of long-term vital signs monitoring using an automatic patient tracking and movement detection algorithm. Our NCVS sensor achieves non-contact heart rate monitoring with accuracies of over 90% (i.e, within ±5 Beats-Per-Minute vs. a reference sensor) across a large number of data points collected over various days of the week inside a typical office cubicle setting at a distance of 1...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227593/an-rf-based-wearable-sensor-system-for-indoor-tracking-to-facilitate-efficient-healthcare-management
#7
Yuzhe Ouyang, Kai Shan, Francis Minhthang Bui, Yuzhe Ouyang, Kai Shan, Francis Minhthang Bui, Yuzhe Ouyang, Kai Shan, Francis Minhthang Bui
To understand the utilization of clinical resources and improve the efficiency of healthcare, it is often necessary to accurately locate patients and doctors in a healthcare facility. However, existing tracking methods, such as GPS, Wi-Fi and RFID, have technological drawbacks or impose significant costs, thus limiting their applications in many clinical environments, especially those with indoor enclosures. This paper proposes a low-cost and flexible tracking system that is well suited for operating in an indoor environment...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227346/respiratory-rate-estimation-from-multilead-directions-based-on-ecg-delineation
#8
M Noriega, E J Maranon, D Romero, M Orini, R Almeida, M Noriega, E J Maranon, D Romero, M Orini, R Almeida, M Orini, M Noriega, R Almeida, D Romero, E J Maranon
Estimating the instantaneous respiratory rate (Rr) from the electrocardiogram (ECG) is of interest as respiration direct measurement in clinical situations is often cumbersome. In this study, the Rr was estimated from the same Final Directions of maximum projection (FD) used for multi lead ECG automatic delineation. Power spectral analysis over the directions based on QRS complex main peak and T wave onset, peak and end spatial loops was used for Rr estimation. On a subset of the Physionet MGH/MF dataset, the proposed method yielded more accurate Rr estimates (minimum mean absolute error (MAE), 2...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227240/measurement-of-shank-angle-during-stance-using-laser-range-finders
#9
Pouya Amiri, Luke J MacLean, Robert E Kearney, Pouya Amiri, Luke J MacLean, Robert E Kearney, Robert E Kearney, Luke J MacLean, Pouya Amiri
Ankle joint stiffness, the dynamic relationship between the joint angle and the torque acting about it, plays an important role in the control of upright stance. In order to identify the contribution of ankle joint stiffness to stance control, ankle joint must be perturbed externally. One way to do this is to displace the foot that will cause shank movement. For identification, the ankle angle must be measured with high accuracy, for which we need to measure both foot and shank angles. However, most motion capture systems do not have the resolution and accuracy needed to measure the small ankle joint movements that occur during stance...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226979/quantitative-assessment-of-arm-tremor-in-people-with-neurological-disorders
#10
Jeonghee Kim, Claire Parnell, Thomas Wichmann, Stephen P DeWeerth, Jeonghee Kim, Claire Parnell, Thomas Wichmann, Stephen P DeWeerth, Claire Parnell, Thomas Wichmann, Stephen P DeWeerth, Jeonghee Kim
Abnormal oscillatory movement (i.e. tremor) is usually evaluated with qualitative assessment by clinicians, and quantified with subjective scoring methods. These methods are often inaccurate. We utilized a quantitative and standardized task based on the Fitts' law to assess the performance of arm movement with tremor by controlling a gyration mouse on a computer. The experiment included the center-out tapping (COT) and rectangular track navigation (RTN) tasks. We report the results of a pilot study in which we collected the performance for healthy participants in whom tremor was simulated by imposing oscillatory movements to the arm with a vibration motor...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226551/beat-to-beat-heart-rate-detection-by-smartphone-s-accelerometers-validation-with-ecg
#11
F Landreani, A Martin-Yebra, C Casellato, C Frigo, E Pavan, P-F Migeotte, E G Caiani, F Landreani, A Martin-Yebra, C Casellato, C Frigo, E Pavan, P-F Migeotte, E G Caiani, A Martin-Yebra, P-F Migeotte, Eg Caiani, F Landreani, C Casellato, C Frigo, E Pavan
: Mobile phones offer the possibility to monitor and track health parameters. Our aim was to test the feasibility and accuracy of measuring beat-to-beat heart rate using smartphone accelerometers by recording the vibrations generated by the heart during its function and transmitted to the chest wall, i.e. the so-called seismocardiographic signal (SCG). METHODS: 9 healthy male volunteers were studied in supine (SUP) and in standing (ST) posture. A smartphone (iPhone6, Apple) was positioned on the thorax (POS1) to acquire SCG signal...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225732/integrating-and-assessing-structural-competency-in-an-innovative-prehealth-curriculum-at-vanderbilt-university
#12
Jonathan M Metzl, JuLeigh Petty
PROBLEM: Structural competency is a framework for conceptualizing and addressing health-related social justice issues that emphasizes diagnostic recognition of economic and political conditions producing and racializing inequalities in health. Strategies are needed to teach prehealth undergraduate students concepts central to structural competency (e.g., structural inequity, structural racism, structural stigma) and to evaluate their impact. APPROACH: The curriculum for Vanderbilt University's innovative prehealth major in medicine, health, and society (MHS) was reshaped in 2013 to incorporate structural competency concepts and skills into undergraduate courses...
March 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28224116/persistence-of-functional-protein-domains-in-mycoplasma-species-and-their-role-in-host-specificity-and-synthetic-minimal-life
#13
Tjerko Kamminga, Jasper J Koehorst, Paul Vermeij, Simen-Jan Slagman, Vitor A P Martins Dos Santos, Jetta J E Bijlsma, Peter J Schaap
Mycoplasmas are the smallest self-replicating organisms and obligate parasites of a specific vertebrate host. An in-depth analysis of the functional capabilities of mycoplasma species is fundamental to understand how some of simplest forms of life on Earth succeeded in subverting complex hosts with highly sophisticated immune systems. In this study we present a genome-scale comparison, focused on identification of functional protein domains, of 80 publically available mycoplasma genomes which were consistently re-annotated using a standardized annotation pipeline embedded in a semantic framework to keep track of the data provenance...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28223475/reduced-first-phase-ejection-fraction-and-sustained-myocardial-wall-stress-in-hypertensive-patients-with-diastolic-dysfunction-a-manifestation-of-impaired-shortening-deactivation-that-links-systolic-to-diastolic-dysfunction-and-preserves-systolic-ejection-fraction
#14
Haotian Gu, Ye Li, Henry Fok, John Simpson, Jonathan C Kentish, Ajay M Shah, Philip J Chowienczyk
Impaired shortening deactivation of cardiac myocytes could sustain myocardial contraction, preserving ejection fraction at the expense of diastolic dysfunction. We examined the relationship between first-phase ejection fraction (EF1), the fraction of left ventricular volume ejected from the start of systole to the time of the first peak in left ventricular pressure (corresponding to the time of maximal ventricular shortening) to the duration of myocardial contraction and diastolic function in patients with hypertension (n=163), and varying degrees of diastolic dysfunction...
February 21, 2017: Hypertension
https://www.readbyqxmd.com/read/28222749/the-impact-of-trans-catheter-aortic-valve-replacement-induced-left-bundle-branch-block-on-cardiac-reverse-remodeling
#15
Laura E Dobson, Tarique A Musa, Akhlaque Uddin, Timothy A Fairbairn, Owen J Bebb, Peter P Swoboda, Philip Haaf, James Foley, Pankaj Garg, Graham J Fent, Christopher J Malkin, Daniel J Blackman, Sven Plein, John P Greenwood
BACKGROUND: Left bundle branch block (LBBB) is common following trans-catheter aortic valve replacement (TAVR) and has been linked to increased mortality, although whether this is related to less favourable cardiac reverse remodeling is unclear. The aim of the study was to investigate the impact of TAVR induced LBBB on cardiac reverse remodeling. METHODS: 48 patients undergoing TAVR for severe aortic stenosis were evaluated. 24 patients with new LBBB (LBBB-T) following TAVR were matched with 24 patients with a narrow post-procedure QRS (nQRS)...
February 22, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28222095/delays-and-loss-to-follow-up-before-treatment-of-drug-resistant-tuberculosis-following-implementation-of-xpert-mtb-rif-in-south-africa-a-retrospective-cohort-study
#16
Helen Cox, Lindy Dickson-Hall, Norbert Ndjeka, Anja Van't Hoog, Alison Grant, Frank Cobelens, Wendy Stevens, Mark Nicol
BACKGROUND: South Africa has a large burden of rifampicin-resistant tuberculosis (RR-TB), with 18,734 patients diagnosed in 2014. The number of diagnosed patients has increased substantially with the introduction of the Xpert MTB/RIF test, used for tuberculosis (TB) diagnosis for all patients with presumptive TB. Routine aggregate data suggest a large treatment gap (pre-treatment loss to follow-up) between the numbers of patients with laboratory-confirmed RR-TB and those reported to have started second-line treatment...
February 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28222083/patients-experiences-with-multiple-myeloma-a-meta-aggregation-of-qualitative-studies
#17
Brynja Hauksdóttir, Marianne E Klinke, Sigríður Gunnarsdóttir, Kristín Björnsdóttir
PROBLEM IDENTIFICATION: To systematically review qualitative evidence regarding patients' experiences of living with multiple myeloma. The main objective was to gain structured understanding of this experience, which is a prerequisite for advancing nursing care and ensuring it is effective.
. LITERATURE SEARCH: Qualitative research articles from January 2005 to March 2016 were located in CINAHL®, PubMed, and Scopus. Supplementary resources were found by scrutinizing reference lists and performing citation tracking...
March 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28221896/accuracy-and-thoroughness-of-treatment-summaries-provided-as-part-of-survivorship-care-plans-prepared-by-two-cancer-centers
#18
Amye J Tevaarwerk, William G Hocking, Jamie L Zeal, Mindy Gribble, Lori Seaborne, Kevin A Buhr, Kari B Wisinski, Mark E Burkard, Douglas A Wiegmann, Mary E Sesto
PURPOSE: Treatment summaries prepared as part of survivorship care planning should correctly and thoroughly report diagnosis and treatment information. METHODS: As part of a clinical trial, summaries were prepared for patients with stage 0 to III breast cancer at two cancer centers. Summaries were prepared per the standard of care at each center via two methods: using the electronic health record (EHR) to create and facilitate autopopulation of content or using manual data entry into an external software program to create the summary...
February 21, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28221383/influence-of-surface-states-and-size-effects-on-the-seebeck-coefficient-and-electrical-resistance-of-bi1-xsbx-nanowire-arrays
#19
M Cassinelli, S Müller, K-O Voss, C Trautmann, F Völklein, J Gooth, K Nielsch, M E Toimil-Molares
The Seebeck coefficient and electrical resistance of Bi1-xSbx nanowire arrays electrodeposited in etched ion-track membranes have been investigated as a function of wire diameter (40-750 nm) and composition (0 ≤ x ≤ 1). The experimental data reveal a non-monotonic dependence between thermopower and wire diameter for three different compositions. Thus, the thermopower values decrease with decreasing wire diameter, exhibiting a minimum around ∼60 nm. This non-monotonic dependence of the Seebeck coefficient is attributed to the interplay of surface and bulk states...
February 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/28219878/features-of-a-mobile-support-app-for-patients-with-chronic-obstructive-pulmonary-disease-literature-review-and-current-applications
#20
Drishty D Sobnath, Nada Philip, Reem Kayyali, Shereen Nabhani-Gebara, Barbara Pierscionek, Anouk W Vaes, Martijn A Spruit, Evangelos Kaimakamis
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a serious long-term lung disease in which the airflow from the lungs is progressively reduced. By 2030, COPD will become the third cause of mortality and seventh cause of morbidity worldwide. With advances in technology and mobile communications, significant progress in the mobile health (mHealth) sector has been recently observed. Mobile phones with app capabilities (smartphones) are now considered as potential media for the self-management of certain types of diseases such as asthma, cancer, COPD, or cardiovascular diseases...
February 20, 2017: JMIR MHealth and UHealth
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