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https://www.readbyqxmd.com/read/28808201/thalamic-paramagnetic-iron-by-t2-relaxometry-correlates-with-severity-of-multiple-sclerosis
#1
Eva Baranovicova, Ema Kantorova, Dagmar Kalenska, Lucia Lichardusova, Michal Bittsan-Sky, Dusan Dobrota
Iron can contribute to the pathogenesis and progression of multiple sclerosis (MS) due to its accumulation in the human brain. We focus on the thalamus as an information transmitter between various subcortical and cortical areas. Thalamic iron seems to follow different rules than iron in other deep gray matter structures and its relation to the clinical outcomes of MS is still indistinct. In our study, we investigated a connection between thalamic iron and patients' disability and course of the disease. The presence of paramagnetic substances in the tissues was tracked by T2* quantification...
July 13, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28798782/evaluation-of-local-carotid-stiffness-and-inflammatory-biomarkers-in-stable-angina-pectoris
#2
Abdullah Nabi Aslan, Ayşe Nur Özcan, Hüseyin Ayhan, Serkan Sivri, Filiz Çelebi, Karabekir Ercan, Tahir Durmaz
INTRODUCTION: Arterial stiffness (AS) is a well-accepted and reliable predictor of atherosclerotic diseases. Inflammation plays an important role in the development of AS. AIM: To evaluate local carotid stiffness (CS) together with fibrinogen and high-sensitivity C-reactive protein (hsCRP) levels in stable angina pectoris (SAP) patients. MATERIAL AND METHODS: The study consisted of 353 consecutive patients with SAP. All underwent coronary angiography (CAG) after the evaluation of local CS parameters and carotid intima-media thickness (IMT) from both common carotid arteries by a real-time echo-tracking system...
2017: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/28774377/association-of-estimated-sodium%C3%A2-intake%C3%A2-with-adverse-cardiac-structure-and%C3%A2-function-from-the-hypergen-study
#3
Senthil Selvaraj, Luc Djoussé, Frank G Aguilar, Eva E Martinez, Vincenzo B Polsinelli, Marguerite R Irvin, Donna K Arnett, Sanjiv J Shah
BACKGROUND: The optimal level of sodium intake remains controversial. OBJECTIVES: This study sought to determine whether examination of left ventricular longitudinal strain (LS), circumferential strain, and e' velocity can provide insight into thresholds for the detrimental effects of estimated sodium intake (ESI) on subclinical cardiovascular disease. METHODS: We performed speckle-tracking analysis on HyperGEN (Hypertension Genetic Epidemiology Network) study echocardiograms with available urinary sodium data (N = 2,996)...
August 8, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28771792/diaphragm-position-can-be-accurately-estimated-from-the-scattering-of-a-parallel-transmit-rf-coil-at-7-t
#4
Aaron T Hess, Elizabeth M Tunnicliffe, Christopher T Rodgers, Matthew D Robson
PURPOSE: To evaluate the use of radiofrequency scattering of a parallel transmit coil to track diaphragm motion. METHODS: Measurements made during radiofrequency excitation on an 8-channel parallel transmit coil by the directional couplers of the radiofrequency safety monitor were combined and converted into diaphragm position. A 30-s subject-specific calibration with an MRI navigator was used to determine a diaphragm estimate from each directional-coupler measure...
August 3, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28764967/ultrasound-imaging-of-muscle-contraction-of-the-tibialis-anterior-in-patients-with-facioscapulohumeral-dystrophy
#5
Kaj Gijsbertse, Rianne Goselink, Saskia Lassche, Maartje Nillesen, André Sprengers, Nico Verdonschot, Nens van Alfen, Chris de Korte
A need exists for biomarkers to diagnose, quantify and longitudinally follow facioscapulohumeral muscular dystrophy (FSHD) and many other neuromuscular disorders. Furthermore, the pathophysiological mechanisms leading to muscle weakness in most neuromuscular disorders are not completely understood. Dynamic ultrasound imaging (B-mode image sequences) in combination with speckle tracking is an easy, applicable and patient-friendly imaging tool to visualize and quantify muscle deformation. This dynamic information provides insight in the pathophysiological mechanisms and may help to distinguish the various stages of diseased muscle in FSHD...
July 29, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28752782/the-feasibility-of-substituting-left-atrial-wall-strain-for-flow-velocity-of-left-atrial-appendage
#6
Akihito Miyoshi, Yoichi Nakamura, Yukio Kazatani, Hiroshi Ito
OBJECTIVE: Non-valvular atrial fibrillation (NVAF) is frequently complicated by thromboembolism. Left atrial appendage (LAA) flow is a predictor of LAA thrombosis. LAA flow is measured by transesophageal echocardiography (TEE), which is a semi-invasive diagnostic tool. Recently, speckle-tracking methods have been adapted for the evaluation of local cardiac function. We hypothesised that if we could determine LAA wall motion utilising a speckle tracking technique, we could non-invasively analyse LAA flow...
July 28, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28752570/a-preliminary-comparison-of-two-dimensional-speckle-tracking-echocardiography-and-pressure-volume-loop-analysis-in-patients-with-fontan-physiology-the-role-of-ventricular-morphology
#7
David Steflik, Ryan J Butts, George H Baker, Varsha Bandisode, Andrew Savage, Andrew M Atz, Shahryar M Chowdhury
OBJECTIVE: Speckle tracking echocardiography (STE) may be a useful modality for assessing ventricular performance in patients with single ventricle physiology. However, STE's ability to accurately assess ventricular performance in this population is unknown. The objective of this study was to perform a preliminary comparison of STE measures of myocardial deformation to reference standard measures of function derived from pressure-volume loop (PVL) analysis. DESIGN: This was a secondary analysis of a prospective study investigating PVLs in patients with Fontan physiology...
July 28, 2017: Echocardiography
https://www.readbyqxmd.com/read/28748092/a-focused-ultrasound-treatment-system-for-moving-targets-part-i-generic-system-design-and-in-silico-first-stage-evaluation
#8
Michael Schwenke, Jan Strehlow, Daniel Demedts, Sabrina Haase, Diego Barrios Romero, Sven Rothlübbers, Caroline von Dresky, Stephan Zidowitz, Joachim Georgii, Senay Mihcin, Mario Bezzi, Christine Tanner, Giora Sat, Yoav Levy, Jürgen Jenne, Matthias Günther, Andreas Melzer, Tobias Preusser
BACKGROUND: Focused ultrasound (FUS) is entering clinical routine as a treatment option. Currently, no clinically available FUS treatment system features automated respiratory motion compensation. The required quality standards make developing such a system challenging. METHODS: A novel FUS treatment system with motion compensation is described, developed with the goal of clinical use. The system comprises a clinically available MR device and FUS transducer system...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/28740456/carotid-artery-stiffness-digital-endothelial-function-and-coronary-calcium-in-patients-with-essential-thrombocytosis-free-of-overt-atherosclerotic-disease
#9
Matjaz Vrtovec, Ajda Anzic, Irena Preloznik Zupan, Katja Zaletel, Ales Blinc
BACKGROUND: Patients with myeloproliferative neoplasms (MPNs) are at increased risk for atherothrombotic events. Our aim was to determine if patients with essential thrombocytosis (ET), a subtype of MPNs, free of symptomatic atherosclerosis, have greater carotid artery stiffness, worse endothelial function, greater coronary calcium and carotid plaque burden than control subjects. PATIENTS AND METHODS: 40 ET patients without overt vascular disease, and 42 apparently healthy, age and sex-matched control subjects with comparable classical risk factors for atherosclerosis and Framingham risk of coronary disease were enrolled...
June 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/28722247/left-ventricular-function-and-regional-strain-with-subtly-tagged-steady-state-free-precession-feature-tracking
#10
Eric M Schrauben, Brett R Cowan, Andreas Greiser, Alistair A Young
PURPOSE: To provide regional strain and ventricular volume from a single acquisition, using subtly tagged steady-state free precession (SubTag SSFP) feature tracking. MATERIALS AND METHODS: The effects on regional strain of tag strength in gradient recalled echo (GRE) tagging, flip angle in untagged balanced SSFP, and both in SubTag SSFP were examined in the mid left ventricle of 15 healthy volunteers at 3T. Optimal parameters were determined from varying both tag strength and SSFP flip angle using full tag saturation GRE as the reference standard...
July 19, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28716687/measures-of-ventricular-arterial-coupling-and-incident-heart-failure-with-preserved-ejection-fraction-a-matched-case-control-analysis
#11
Carolyn L Lekavich, Debra J Barksdale, Jia-Rong Wu, Virginia Neelon, Jamie Crandell, Eric J Velazquez
BACKGROUND: Evidence continues to demonstrate increasing prevalence, cost, and mortality implications of heart failure with preserved ejection fraction (HFpEF), but clearly defined parameters that distinguish between control subjects and HFpEF have not been established. OBJECTIVES: This study was designed to detect differences in markers associated with Ventricular-arterial coupling and HFpEF when comparing matched case and control groups. METHODS: A study cohort of case (incident patients with HFpEF; n = 155) and matched control (patients with no prior heart failure; n = 155) groups was retrospectively identified...
July 14, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28678927/global-longitudinal-strain-or-left-ventricular-twist-and-torsion-which-correlates-best-with-ejection-fraction
#12
Marcio Silva Miguel Lima, Hector R Villarraga, Maria Cristina Donadio Abduch, Marta Fernandes Lima, Cecilia Beatriz Bittencourt Viana Cruz, João Cesar Nunes Sbano, Mariana Callil Voos, Wilson Mathias, Jeane Mike Tsutsui
Background: Estimative of left ventricular ejection fraction (LVEF) is a major indication for echocardiography. Speckle tracking echocardiography (STE) allows analysis of LV contraction mechanics which includes global longitudinal strain (GLS) and twist/torsion, both the most widely used. Direct comparison of correlations between these novel parameters and LVEF has never been done before. Objective: This study aims to check which one has the highest correlation with LVEF...
July 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28669395/afterload-dependence-of-right-ventricular-myocardial-strain
#13
Leah Wright, Kazuaki Negishi, Nathan Dwyer, Sudhir Wahi, Thomas H Marwick
BACKGROUND: Right ventricular (RV) free wall strain (RVFWS) is a feasible method for quantitation and follow-up of RV function and may have benefits over traditional markers such as fractional area change. However, like all ejection phase parameters, RVFWS is difficult to assess in the presence of changing afterload. The aim of this study was to compare RVFWS and traditional RV function parameters for tracking progress of RV function in patients with pulmonary arterial hypertension (PAH) over a range of pulmonary artery systolic pressure (PASPs)...
July 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28664568/circulating-microrna-in-patients-with-repaired-tetralogy-of-fallot
#14
Clare T M Lai, Enders K O Ng, Pak-Cheong Chow, Ava Kwong, Yiu-Fai Cheung
BACKGROUND: Emerging data suggest that heart-related microRNAs (miRs) may serve as circulating biomarkers of myocardial injury. We aimed to determine the circulating profile of miRs in patients with volume-overloaded right ventricles after repair of tetralogy (TOF). MATERIALS AND METHODS: A total of 104 TOF patients and 70 controls were recruited. The study was conducted in two phases: (1) determination of circulating heart-related miRs described in left heart diseases (miR-1, miR-133a, miR-208a, miR-208b and miR423-5p) by quantitative real-time PCR in 49 patients and 30 controls and followed by validation in an independent cohort of 55 patients and 40 controls; (2) expression profiling of serum samples from eight patients and eight controls, followed by validation...
June 29, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28664480/usefulness-of-left-ventricular-speckle-tracking-echocardiography-and-novel-measures-of-left-atrial-structure-and-function-in-diagnosing-paroxysmal-atrial-fibrillation-in-ischemic-stroke-and-transient-ischemic-attack-patients
#15
Kristoffer Grundtvig Skaarup, Hanne Christensen, Nis Høst, Masti Mahdy Mahmoud, Christian Ovesen, Flemming Javier Olsen, Jan Skov Jensen, Tor Biering-Sørensen
Asymptomatic paroxysmal atrial fibrillation (PAF) is often assumed to be the cause of cryptogenic ischemic strokes (IS) and transient ischemic attacks (TIA). We examined the usefulness of measures obtained by 2D speckle tracking echocardiography and novel left atrial measurements, in the diagnosis of PAF in patients with IS and TIA. We retrospectively included 205 patients who after acute IS or TIA underwent an echocardiogram in sinus rhythm. Patients were designated as PAF-patients if they had one or more reported incidents of AF before or after their echocardiographic examination...
June 29, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28655468/revisiting-the-cram%C3%A3-r-rao-lower-bound-for-elastography-predicting-the-performance-of-axial-lateral-and-polar-strain-elastograms
#16
Prashant Verma, Marvin M Doyley
We derived the Cramér Rao lower bound for 2-D estimators employed in quasi-static elastography. To illustrate the theory, we modeled the 2-D point spread function as a sinc-modulated sine pulse in the axial direction and as a sinc function in the lateral direction. We compared theoretical predictions of the variance incurred in displacements and strains when quasi-static elastography was performed under varying conditions (different scanning methods, different configuration of conventional linear array imaging and different-size kernels) with those measured from simulated or experimentally acquired data...
June 24, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28648418/longitudinal-ventricular-systolic-dysfunction-in-patients-with-very-severe-obstructive-sleep-apnea-a-case-control-study-using-speckle-tracking-imaging
#17
Mithun Jacob Varghese, Gautam Sharma, Garima Shukla, Sandeep Seth, Sundeep Mishra, Anupama Gupta, Vinay Kumar Bahl
OBJECTIVE: Obstructive sleep apnea (OSA) is a prevalent condition that is increasingly recognized to be associated with cardiovascular disease. We aimed to investigate the subclinical systolic ventricular dysfunction of patients with OSA using novel speckle tracking echocardiographic (STE) techniques. METHODS: This study included 31 patients of polysomnography proven very severe OSA [Apnea Hypopnea Index(AHI) >40] and an equal number of matched population with no OSA as controls...
May 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28647901/in-vivo-visualization-of-the-locus-coeruleus-in-humans-quantifying-the-test-retest-reliability
#18
Klodiana-Daphne Tona, Max C Keuken, Mischa de Rover, Egbert Lakke, Birte U Forstmann, Sander Nieuwenhuis, Matthias J P van Osch
The locus coeruleus (LC) is a brainstem nucleus involved in important cognitive functions. Recent developments in neuroimaging methods and scanning protocols have made it possible to visualize the human LC in vivo by utilizing a T1-weighted turbo spin echo (TSE) scan. Despite its frequent use and its application as a biomarker for tracking the progress of monoaminergic-related neurodegenerative diseases, no study to date has investigated the reproducibility and inter-observer variability of LC identification using this TSE scan sequence...
June 24, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28647400/intraoperative-registered-ultrasound-and-fluoroscopy-iruf-for-dose-calculation-during-prostate-brachytherapy-improved-accuracy-compared-to-standard-ultrasound-based-dosimetry
#19
Junghoon Lee, Omar Y Mian, Yi Le, Hee Joon Bae, E Clif Burdette, Theodore L DeWeese, Jerry L Prince, Daniel Y Song
BACKGROUND AND PURPOSE: Intraoperative transrectal ultrasound dosimetry during low-dose-rate prostate brachytherapy is imprecise due to sonographic distortion caused by seed echoes and needle tracks that obscure seed positions or create false signals as well as traumatic edema. Here we report the results of a pilot study comparing a combined ultrasound and fluoroscopy-based seed localization method (iRUF) to standard ultrasound-based dosimetry (USD). MATERIAL AND METHODS: Eighty patients undergoing permanent Pd-103 seed implantation for prostate cancer were prospectively enrolled...
July 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28643530/assessment-of-local-carotid-stiffness-in-seronegative-and-seropositive-rheumatoid-arthritis
#20
Abdullah Nabi Aslan, Ayşe Nur Şirin Özcan, Şükran Erten, Yakup Alsancak, Tahir Durmaz
OBJECTIVES: Rheumatoid arthritis (RA) is a chronic, inflammatory disease associated with increased risk of cardiovascular (CV) disease. Arterial stiffness (AS) is an independent predictor of CV events. This study aimed to analyse local carotid AS parameters in seronegative and seropositive RA patients. DESIGN: Of 347 consecutive RA patients, we selected specifically those who were free of established CV diseases and risk factors. As a result, 140 patients (126 women, 52...
June 23, 2017: Scandinavian Cardiovascular Journal: SCJ
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