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https://www.readbyqxmd.com/read/29925575/implementation-of-duchenne-muscular-dystrophy-care-considerations
#1
Jennifer G Andrews, Kristin Conway, Christina Westfield, Christina Trout, F John Meaney, Katherine Mathews, Emma Ciafaloni, Christopher Cunniff, Deborah J Fox, Dennis Matthews, Shree Pandya
BACKGROUND: Duchenne muscular dystrophy (DMD) is an X-linked disorder characterized by progressive muscle weakness and multisystem involvement. Recent advances in management of individuals with DMD have prolonged survival. Lack of standardized care spurred an international collaboration to develop consensus-based care considerations for diagnosis and management. In this study, we evaluate adherence to considerations at selected sites. METHODS: We collaborated with the Muscular Dystrophy Surveillance, Tracking, and Research Network...
June 20, 2018: Pediatrics
https://www.readbyqxmd.com/read/29888525/consistency-of-novel-ultrasound-equations-for-estimating-percent-intramuscular-fat
#2
Adam M Burton, Matt S Stock
INTRODUCTION: Echo intensity reflects both intramuscular adiposity and fibrous tissue content. Recently, equations that allow investigators to estimate the percentage of intramuscular fat for individual muscles via measurements of echo intensity and subcutaneous fat were created. However, as the trial-to-trial consistency of these values has not been reported in the literature, it is unclear if they can be used to track changes during physical activity and/or nutritional interventions...
June 11, 2018: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/29864851/a-digital-constant-frequency-pulsed-phase-locked-loop-instrument-for-real-time-absolute-ultrasonic-phase-measurements
#3
H A Haldren, D F Perey, W T Yost, K E Cramer, M C Gupta
A digitally controlled instrument for conducting single-frequency and swept-frequency ultrasonic phase measurements has been developed based on a constant-frequency pulsed phase-locked-loop (CFPPLL) design. This instrument uses a pair of direct digital synthesizers to generate an ultrasonically transceived tone-burst and an internal reference wave for phase comparison. Real-time, constant-frequency phase tracking in an interrogated specimen is possible with a resolution of 0.000 38 rad (0.022°), and swept-frequency phase measurements can be obtained...
May 2018: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29848216/method-for-recovering-lost-ultrasonic-information-using-the-echo-intensity-mean
#4
Sara Bahramian, Craig K Abbey, Michael F Insana
The axial resolution of a B-mode (or intensity) image is limited by the bandwidth of the pulse envelope. In this report, we investigate the source of this limitation by examining the transfer of high-resolution information from the tissue impedance variance throughout the imaging process. For that purpose, we express the mean and variance of the echo-intensity signal as a linear system to track the flow of object information along the image-formation chain. The results reveal how demodulation influences the available information by discarding high spatial-frequency information...
May 1, 2018: Ultrasonic Imaging
https://www.readbyqxmd.com/read/29808387/findings-on-3d-speckle-tracking-echocardiography-in-asymptomatic-methamphetamine-abusers
#5
Li-Juan Zhang, Ke-Qi Chen, Yun-Yan Shi, Xiao-Ling Qiao, Lian-You Wang, Xiao-Zhi Zheng
To detect potential cardiac abnormalities in asymptomatic methamphetamine abusers using three-dimensional speckle tracking echocardiography (3D STE). Fifty-three male methamphetamine abusers, free of cardiac symptoms/signs, were enrolled in this study. A control group of 53 age-matched male normal subjects was studied for comparison. Standard 3D, flow and tissue Doppler echo with measurements of left ventricular end-diastolic volume (LVEDV), end-systolic volume (LVESV), ejection fraction (LVEF), the ratio of the early to late diastolic transmitral filling velocity (E/A), the ratio of the early diastolic transmitral filling velocity to the early diastolic septal tissue velocity (E/E') and 3D STE with measurements of global area strain (GAS), global longitudinal strain (GLS), global circumferential strain (GCS) and global radial strain (GRS) were performed, respectively...
May 28, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29789916/two-dimensional-speckle-tracking-echocardiography-derived-strain-measurements-in-survivors-of-childhood-cancer-on-angiotensin-converting-enzyme-inhibition-or-receptor-blockade
#6
Jamie K Harrington, Marc E Richmond, Arielle W Fein, Serge Kobsa, Prakash Satwani, Amee Shah
Speckle tracking echocardiography (STE)-derived strain indices are believed to detect early cardiac dysfunction in survivors of childhood cancer and have potential to identify patients who may benefit from early heart failure treatment. However, effects of heart failure treatment on STE-derived strain measurements in this population are unknown. The aim of this study was to assess STE-derived strain measurements in survivors of childhood cancer treated with angiotensin converting enzyme inhibition or receptor blockade (ACEi/ARB)...
May 22, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29784436/a-3-d-region-growing-motion-tracking-method-for-ultrasound-elasticity-imaging
#7
Yuqi Wang, Jingfeng Jiang, Timothy J Hall
A 3-D region-growing motion-tracking (RGMT) method for ultrasound elasticity imaging is described. This 3-D RGMT method first estimates the displacements at a sparse subset of points, called seeds; uses an objective measure to determine, among those seeds, which displacement estimates to trust; and then performs RGMT in three dimensions to estimate displacements for the remaining points in the field. During the growing process in three dimensions, the displacement estimate at one grid point is employed to guide the displacement estimation of its neighboring points using a 3-D small search region...
May 18, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29763816/design-of-a-phase-3-trial-of-intracoronary-administration-of-human-adenovirus-5-encoding-human-adenylyl-cyclase-type-6-rt-100-gene-transfer-in-patients-with-heart-failure-with-reduced-left-ventricular-ejection-fraction-the-flourish-clinical-trial
#8
William F Penny, Timothy D Henry, Matthew W Watkins, Amit N Patel, H Kirk Hammond
The prognosis of patients with HFrEF remains poor despite the use of current medical and device therapies. Preclinical studies of HFrEF using IC delivery of RT-100, a replication deficient, E1/E3-deleted human adenovirus 5 encoding human AC6 was associated with favorable effects on LV function and remodeling. A recent multicenter, double-blind, placebo-controlled, phase 2 study demonstrated the safety of IC delivery of RT-100 in HFrEF patients and potential efficacy at the higher doses. This phase 2 dose finding study, which included doses not expected to be effective, identified a potential reduction in congestive heart failure admissions in the AC6-treated group one year after randomization...
April 6, 2018: American Heart Journal
https://www.readbyqxmd.com/read/29752666/lung-water-assessment-from-gravimetry-to-wearables
#9
Frederic Michard
Several techniques are now available to detect and quantify pulmonary edema, from the laboratory postmortem method (gravimetry) to non-invasive wearable sensors. In critically ill patients with adult respiratory distress syndrome (ARDS), computed tomography scans are often performed to visualize lung lesions and quantify lung aeration, but their value seems somewhat limited to quantify pulmonary edema on a routine basis and of course to track changes with therapy. In this context, transpulmonary thermodilution is a convenient technique...
May 11, 2018: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29750540/read-out-segmented-echo-planar-diffusion-imaging-of-the-female-pelvis-utility-in-endometrial-carcinoma-a-preliminary-experience
#10
Adarsh Ghosh, Tulika Singh, Veenu Singla, Rashmi Bagga, Radhika Srinivasan, Niranjan Khandelwal
OBJECTIVE: Susceptibility artefacts from bones and bowel, geometric distortion make diffusion imaging of the pelvis difficult. We discuss the difficulties of single-shot-echoplanar[ss-ep ]DWI and evaluate a new diffusion-weighted imaging technique - readout segmented echo planar[ rs-ep]DWI in endometrial carcinoma and discuss the imaging physics. METHODS: IRB approval was obtained and five consecutive patients underwent both rs-ep and ss-ep-DWI of the female pelvis and two radiologists compared the images...
May 11, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29749652/evolution-of-echocardiography-in-subclinical-detection-of-cancer-therapy-related-cardiac-dysfunction
#11
REVIEW
Rohit Moudgil, Saamir Hassan, Nicolas Palaskas, Juan Lopez-Mattei, Jose Banchs, Syed Wamique Yusuf
Cancer therapies have resulted in increased survivorship in oncological patients. However, the benefits have been marred by the development of premature cardiovascular disease. The current definition outlines measurement of ejection fraction as a mean to diagnose cancer therapeutic-related cardiac dysfunction (CTRCD); however, up to 58% of the patients do not regain their cardiac function after the CTRCD diagnosis, despite therapeutic interventions. Therefore, there has been a growing interest in the markers for early myocardial changes (ie, changes with normal left ventricular ejection fraction [LVEF]) that may predict the development of subsequent left ventricular ejection fraction reduction or progression to heart failure...
May 11, 2018: Echocardiography
https://www.readbyqxmd.com/read/29744621/carotid-artery-intima-media-thickness-measurement-in-children-with-normal-and-increased-body-mass-index-a-comparison-of-three-techniques
#12
Ramy El Jalbout, Guy Cloutier, Marie-Hélène Roy Cardinal, Mélanie Henderson, Chantale Lapierre, Gilles Soulez, Josée Dubois
BACKGROUND: Common carotid artery intima-media thickness is a marker of subclinical atherosclerosis. In children, increased intima-media thickness is associated with obesity and the risk of cardiovascular events in adulthood. OBJECTIVE: To compare intima-media thickness measurements using B-mode ultrasound, radiofrequency (RF) echo tracking, and RF speckle probability distribution in children with normal and increased body mass index (BMI). MATERIALS AND METHODS: We prospectively measured intima-media thickness in 120 children randomly selected from two groups of a longitudinal cohort: normal BMI and increased BMI, defined by BMI ≥85th percentile for age and gender...
May 9, 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29735558/statistics-of-natural-communication-signals-observed-in-the-wild-identify-important-yet-neglected-stimulus-regimes-in-weakly-electric-fish
#13
Jörg Henninger, Rüdiger Krahe, Frank Kirschbaum, Jan Grewe, Jan Benda
Sensory systems evolve in the ecological niches each species is occupying. Accordingly, encoding of natural stimuli by sensory neurons is expected to be adapted to the statistics of these stimuli. For a direct quantification of sensory scenes we tracked natural communication behavior of male and female weakly electric fish, Apteronotus rostratus , in their Neotropical rainforest habitat with high spatio-temporal resolution over several days. In the context of courtship we observed large quantities of electrocommunication signals...
May 7, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29724583/evaluation-of-tricuspid-annular-plane-systolic-excursion-measured-by-two-dimensional-echocardiography-in-healthy-dogs-repeatability-reference-intervals-and-comparison-with-m-mode-assessment
#14
L C Visser, D J Sintov, M S Oldach
INTRODUCTION: We sought to determine the feasibility, measurement variability, and within-day repeatability of tricuspid annular plane systolic excursion (TAPSE) measured by two-dimensional echocardiography (2D TAPSE), generate reference intervals for 2D TAPSE, assess agreement and correlation between 2D TAPSE and the conventional TAPSE measured by M-mode echocardiography (MM TAPSE), and to assess the ability of 2D TAPSE to track a drug-induced decrease in right ventricular (RV) function compared with MM TAPSE...
April 30, 2018: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/29700783/modeling-right-ventricle-failure-after-continuous-flow-left-ventricular-assist-device-a-biventricular-finite-element-and-lumped-parameter-analysis
#15
Francesco Scardulla, Valentina Agnese, Giuseppe Romano, Gabriele Di Gesaro, Sergio Sciacca, Diego Bellavia, Francesco Clemenza, Michele Pilato, Salvatore Pasta
The risk of right ventricle (RV) failure remains a major contraindication for continuous-flow left ventricular assist device (CF-LVAD) implantation in patients with heart failure. It is therefore critical to identify the patients who will benefit from early intervention to avoid adverse outcomes. We sought to advance the computational modeling description of the mechanisms underlying RV failure in LVAD-supported patients. RV failure was studied by computational modeling of hemodynamic and cardiac mechanics using lumped-parameter and biventricular finite element (FE) analysis...
April 26, 2018: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/29693582/ultrasound-pulse-echo-coupled-with-a-tracking-technique-for-simultaneous-measurement-of-multiple-bubbles
#16
Antonin Povolny, Hiroshige Kikura, Tomonori Ihara
Bubbly flows are commonly used in various applications and their measurement is an important research topic. The ultrasound pulse-echo technique allows for the detection of each bubble and the measurement of the position of its surface. However, so far it has been used only to measure single bubbles. This paper investigates whether the pulse-echo technique can be applied for measuring multiple bubbles concurrently. The ultrasonic transducer wavelength and diameter were selected based on expected bubble diameters so that each bubble produced a strong reflection...
April 25, 2018: Sensors
https://www.readbyqxmd.com/read/29691224/echo-and-heart-failure-when-do-people-need-an-echo-and-when-do-they-need-natriuretic-peptides
#17
REVIEW
Daniel Modin, Ditte Madsen Andersen, Tor Biering-Sørensen
Heart failure (HF) is a threat to public health. Heterogeneities in aetiology and phenotype complicate the diagnosis and management of HF. This is especially true when considering HF with preserved ejection fraction (HFpEF), which makes up 50% of HF cases. Natriuretic peptides may aid in establishing a working diagnosis in patients suspected of HF, but echocardiography remains the optimal choice for diagnosing HF. Echocardiography provides important prognostic information in both HF with reduced ejection fraction (HFrEF) and HFpEF...
June 2018: Echo Research and Practice
https://www.readbyqxmd.com/read/29680337/t1-mapping-by-cardiac-magnetic-resonance-and-multidimensional-speckle-tracking-strain-by-echocardiography-for-the-detection-of-acute-cellular-rejection-in-cardiac-allograft-recipients
#18
Leyla Elif Sade, Tuncay Hazirolan, Hatice Kozan, Handan Ozdemir, Mutlu Hayran, Serpil Eroglu, Bahar Pirat, Atilla Sezgin, Haldun Muderrisoglu
OBJECTIVES: The aim of this study was to test the hypothesis that echocardiographic strain imaging, by tracking subtle alterations in myocardial function, and cardiac magnetic resonance T1 mapping, by quantifying tissue properties, are useful and complement each other to detect acute cellular rejection in heart transplant recipients. BACKGROUND: Noninvasive alternatives to endomyocardial biopsy are highly desirable to monitor acute cellular rejection. METHODS: Surveillance endomyocardial biopsies, catheterizations, and echocardiograms performed serially according to institutional protocol since transplantation were retrospectively reviewed...
April 14, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29669563/a-comparison-of-both-dense-and-feature-tracking-techniques-with-tagging-for-the-cardiovascular-magnetic-resonance-assessment-of-myocardial-strain
#19
J Jane Cao, Nora Ngai, Lynette Duncanson, Joshua Cheng, Kathleen Gliganic, Qizhi Chen
BACKGROUND: Myocardial strain is increasingly recognized as an important assessment for myocardial function. In addition, it also improves outcome prediction. However, there is lack of standardization in strain evaluation by cardiovascular magnetic resonance (CMR). In this study we compared strain values using multiple techniques and multiple vendor products. METHODS: Prospectively recruited patients with cardiomyopathy of diverse etiology (N = 77) and healthy controls (N = 10) underwent CMR on a 1...
April 19, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29661525/a-preliminary-study-of-left-ventricular-rotational-mechanics-in-children-with-noncompaction-cardiomyopathy-do-they-influence-ventricular-function
#20
Hythem M Nawaytou, Andrea E Montero, Putri Yubbu, Renzo J C Calderón-Anyosa, Tomoyuki Sato, Matthew J O'Connor, Kelley D Miller, Philip C Ursell, Julien I E Hoffman, Anirban Banerjee
BACKGROUND: Current diagnostic criteria for noncompaction cardiomyopathy (NCC) lack specificity, and the disease lacks prognostic indicators. Reverse apical rotation (RAR) with abnormal rotation of the cardiac apex in the same clockwise direction as the base has been described in adults with NCC. The aim of this study was to test the hypothesis that RAR might differentiate between symptomatic NCC and benign hypertrabeculations and might be associated with ventricular dysfunction. METHODS: Echocardiograms from 28 children with NCC without cardiac malformations were prospectively compared with those from 29 age-matched normal control subjects...
April 13, 2018: Journal of the American Society of Echocardiography
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