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https://www.readbyqxmd.com/read/29621136/complex-regulatory-networks-governing-production-of-the-glycopeptide-a40926
#1
REVIEW
Rosa Alduina, Margherita Sosio, Stefano Donadio
Glycopeptides (GPAs) are an important class of antibiotics, with vancomycin and teicoplanin being used in the last 40 years as drugs of last resort to treat infections caused by Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus . A few new GPAs have since reached the market. One of them is dalbavancin, a derivative of A40926 produced by the actinomycete Nonomuraea sp. ATCC 39727, recently classified as N. gerenzanensis . This review summarizes what we currently know on the multilevel regulatory processes governing production of the glycopeptide A40926 and the different approaches used to increase antibiotic yields...
April 5, 2018: Antibiotics
https://www.readbyqxmd.com/read/29535547/effects-of-resistant-maltodextrin-on-bowel-movements-a-systematic-review-and-meta-analysis
#2
REVIEW
Norikazu Watanabe, Masataka Suzuki, Yoshitake Yamaguchi, Yukari Egashira
It is well known that dietary fiber helps to relieve and prevent constipation, and there are a number of scientific papers, including systematic reviews and meta-analyses on the effects of naturally derived dietary fiber on bowel movements. In recent years, there has been an increase in the manufacture of dietary fiber ingredients obtained from food raw materials, and these are now commonly available in the market. Resistant maltodextrin (RMD), a soluble dietary fiber, is manufactured from starch, and industrially produced soluble dietary fiber is used worldwide...
2018: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/29532291/the-effect-of-cyp1a2-genotype-on-the-ergogenic-properties-of-caffeine-during-resistance-exercise-a-randomized-double-blind-placebo-controlled-crossover-study
#3
Rahman Rahimi
AIM: The purpose of this study was to examine the effect of CYP1A2 -163C>A polymorphism on the ergogenic effects of caffeine supplementation during a resistance exercise (RE) session. METHODS: In a randomized, double-blind, placebo (PL)-controlled, crossover study, 30 resistance-trained men took part in two RE sessions (three sets to failure at 85% of one repetition maximum, 2-min rest between sets), including bench press (BP), leg press (LP), seated cable row, and shoulder press (SP) following caffeine (CAF) (6 mg kg-1 ) or PL (6 mg kg-1 of maltodextrin) ingestion 1 h prior to the trial...
March 12, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29480399/the-effect-of-resistant-dextrin-as-a-prebiotic-on-metabolic-parameters-and-androgen-level-in-women-with-polycystic-ovarian-syndrome-a-randomized-triple-blind-controlled-clinical-trial
#4
Sevda Gholizadeh Shamasbi, Parvin Dehgan, Sakineh Mohammad-Alizadeh Charandabi, Akbar Aliasgarzadeh, Mojgan Mirghafourvand
INTRODUCTION: Polycystic ovary syndrome (PCOS) is one of the most common abnormalities in women of reproductive age that can lead to a variety of metabolic and reproductive disorders. Studies reveal that a healthy diet is the most effective way for treating the risk factors associated with metabolic disorders and place greater emphasis on the consumption of prebiotic foods. The present study aims to determine the effect of resistant Dextrin on metabolic parameters, including lipid profile, fasting blood glucose (FBS) and high sensitivity C-reactive protein (hsCRP), and androgen levels, including serum levels of dehydroepiandrosterone sulfate (DHEA-S) and free testosterone, as the primary outcomes, and manifestations of PCOS including menstrual cycle irregularity and hirsutism, as the secondary outcomes...
February 26, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29460278/structural-and-metabolic-responses-of-staphylococcus-aureus-biofilms-to-hyperosmotic-and-antibiotic-stress
#5
Mia Mae Kiamco, Abdelrhman Mohamed, Patrick Reardon, Carrie Marean-Reardon, Wrya Moh Aframehr, Douglas R Call, Haluk Beyenal, Ryan Renslow
Biofilms alter their metabolism in response to environmental stress. This study explores the effect of a hyperosmotic agent-antibiotic treatment on the metabolism of Staphylococcus aureus biofilms through the use of nuclear magnetic resonance (NMR) techniques. To determine the metabolic activity of S. aureus, we quantified the concentrations of metabolites in spent medium using high-resolution NMR spectroscopy. Biofilm porosity, thickness, biovolume, and relative diffusion coefficient depth profiles were obtained using NMR microimaging...
February 20, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29356594/proteomic-analysis-of-alterations-in-aeromonas-hydrophila-outer-membrane-proteins-in-response-to-oxytetracycline-stress
#6
Ling Lin, Lina Sun, Farman Ali, Zhuang Guo, Liang Zhang, Wenxiong Lin, Xiangmin Lin
In Gram-negative bacteria, the outer membrane proteins (OMPs) perform a crucial role in antibiotic resistance, but it is largely unknown how they behave in response to antibiotic stress. In this study, we treated Aeromonas hydrophila with two different doses of oxytetracycline (OXY) to induce antibiotic stress. Proteins were isolated from sarcosine-insoluble fractions and quantitatively examined by using tandem mass tag labeling-based mass spectrometry to identify differentially expressed proteins. As a result, we identified 125 differential proteins in the 5 μg/ml OXY treatment group, including 20 OMPs, and 150 proteins from the 10 μg/ml OXY group, including 22 OMPs...
January 22, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29191195/maternal-dietary-free-or-bound-fructose-diversely-influence-developmental-programming-of-lipogenesis
#7
Armagan Aytug Yuruk, Reyhan Nergiz-Unal
BACKGROUND: Maternal dietary choices throughout preconception, pregnancy, and lactation irreversibly affect the development of fetal tissues and organs, known as fetal programming. Recommendations tend to emphasize reducing added sugars. However, the impact of maternal dietary free or bound fructose in added sugars on developmental programming of lipogenesis is unknown. METHODS: Virgin Sprague-Dawley rats were randomly divided into five groups. Rats were given feed and plain water (control) or water containing maltodextrin (vehicle), fructose, high-fructose corn syrup (HFCS) containing 55% fructose, sucrose (20% w/v) for 12 weeks before mating and throughout the pregnancy and lactation periods...
December 1, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29173029/enzymatically-synthesized-megalo-type-isomaltosaccharides-enhance-the-barrier-function-of-the-tight-junction-in-the-intestinal-epithelium
#8
Hiroshi Hara, Shunsuke Kume, Takahisa Iizuka, Yoshinori Fujimoto, Atsuo Kimura
Megalo-type isomaltosaccharides are an enzymatically synthesized foodstuff produced by transglucosylation from maltodextrin, and they contain a mid-chain length polymer of D-glucose with α-1,6-glycoside linkages. The injection of a solution of megalo-type isomaltosaccharides (1-4%(w/v), average DP = 12.6), but not oligo-type isomaltosaccharides (average DP = 3.3), into the intestinal lumen dose-dependently reduced the transport rates of tight junction permeable markers in a ligated loop of the anesthetized rat jejunum...
November 27, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29155076/genotoxicity-and-28-day-oral-toxicity-studies-of-a-functional-food-mixture-containing-maltodextrin-white-kidney-bean-extract-mulberry-leaf-extract-and-niacin-bound-chromium-complex
#9
Cheng-Tien Wu, Chen-Yuan Chiu, Chun-Fa Huang, Fu-Chuo Peng, Shing-Hwa Liu
Steady-fiber granule (SFG) is a functional food mixture that is composed of four major ingredients, resistant maltodextrin, white kidney bean (Phaseolus vulgaris) extract, mulberry leaf (Morus alba L.) extract, and niacin-bound chromium complex. This study focused on determining the safety of SFG. Genotoxicity and 28-day oral toxicity were evaluated. SFG did not induce mutagenicity in the bacterial reverse mutation assay using five Salmonella typhimurium strains (TA98, TA100, TA102, TA1535, and TA1537) in the presence or absence of metabolic activation (S9 system)...
February 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29128103/the-benefits-of-a-low-dose-complex-carbohydrate-citrulline-electrolyte-solution-for-preoperative-carbohydrate-loading-focus-on-glycemic-variability
#10
Barrett A Kielhorn, Anthony J Senagore, Theodor Asgeirsson
BACKGROUND: Perioperative insulin resistance is associated with significant hyperglycemia-related morbidity in patients undergoing major surgery. We sought to assess the effect of preoperative loading with a low-dose maltodextrin/citrulline solution compared to a commercially available sports drink on glycemic levels in an established colorectal enhanced recovery program. METHODS: Retrospective analysis was undertaken of elective non-diabetic colectomies and enterectomies from January 2016-March 2017...
November 8, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28963124/effect-of-light-load-resistance-exercise-on-postprandial-amino-acid-transporter-expression-in-elderly-men
#11
Jakob Agergaard, Jacob Bülow, Jacob K Jensen, Søren Reitelseder, Andreas Bornø, Micah J Drummond, Peter Schjerling, Lars Holm
An impaired amino acid sensing is associated with age-related loss of skeletal muscle mass. We tested whether light-load resistance exercise (LL-RE) affects postprandial amino acid transporter (AAT) expression in aging skeletal muscle. Untrained, healthy men (age: +65 years) were subjected to 13 h of supine rest. After 2 1/2 h of rest, unilateral LL-RE was conducted (leg extensions, 10 sets of 36 repetitions) at 16% 1RM Thereafter, the subjects were randomized into groups that orally ingested 40 g of whey protein either as hourly drinks (4 g per drink) (PULSE, N = 10) or two boluses (28 g at 0 h and 12 g at 7 h) (BOLUS, N = 10), or hourly isocaloric maltodextrin drinks (placebo, N = 10)...
September 2017: Physiological Reports
https://www.readbyqxmd.com/read/28959158/effects-of-a-pre-workout-supplement-on-hyperemia-following-leg-extension-resistance-exercise-to-failure-with-different-resistance-loads
#12
Jeffrey S Martin, Petey W Mumford, Cody T Haun, Micheal J Luera, Tyler W D Muddle, Ryan J Colquhoun, Mary P Feeney, Cameron S Mackey, Paul A Roberson, Kaelin C Young, David D Pascoe, Jason M DeFreitas, Nathaniel D M Jenkins, Michael D Roberts
BACKGROUND: We sought to determine if a pre-workout supplement (PWS), containing multiple ingredients thought to enhance blood flow, increases hyperemia associated with resistance training compared to placebo (PBO). Given the potential interaction with training loads/time-under-tension, we evaluated the hyperemic response at two different loads to failure. METHODS: Thirty males participated in this double-blinded study. At visit 1, participants were randomly assigned to consume PWS (Reckless™) or PBO (maltodextrin and glycine) and performed four sets of leg extensions to failure at 30% or 80% of their 1-RM 45-min thereafter...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28911684/a-randomized-double-blind-clinical-study-to-determine-the-effect-of-ankascin-568-plus-on-blood-glucose-regulation
#13
RANDOMIZED CONTROLLED TRIAL
Yin-Ruei Wang, Sheng-Fu Liu, You-Cheng Shen, Chien-Li Chen, Chine-Ning Huang, Tzu-Ming Pan, Chin-Kun Wang
Diabetes is the fourth major cause of death in Taiwan. High blood glucose can lead to macrovascular diseases, small vessel diseases (retinopathy, kidney disease), and neuropathy. This study aimed to investigate whether Monascus-fermented products (ANKASCIN 568 plus) can regulate blood glucose and blood lipids. This study enrolled 39 patients with a fasting blood glucose level between 100 mg/dL and 180 mg/dL, and a glycated hemoglobin (HbA1c) level of <9%. All patients were randomly divided into placebo (n=20) and experimental (n=19) groups...
April 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28869573/effects-of-whey-soy-or-leucine-supplementation-with-12-weeks-of-resistance-training-on-strength-body-composition-and-skeletal-muscle-and-adipose-tissue-histological-attributes-in-college-aged-males
#14
C Brooks Mobley, Cody T Haun, Paul A Roberson, Petey W Mumford, Matthew A Romero, Wesley C Kephart, Richard G Anderson, Christopher G Vann, Shelby C Osburn, Coree D Pledge, Jeffrey S Martin, Kaelin C Young, Michael D Goodlett, David D Pascoe, Christopher M Lockwood, Michael D Roberts
We sought to determine the effects of L-leucine (LEU) or different protein supplements standardized to LEU (~3.0 g/serving) on changes in body composition, strength, and histological attributes in skeletal muscle and adipose tissue. Seventy-five untrained, college-aged males (mean ± standard error of the mean (SE); age = 21 ± 1 years, body mass = 79.2 ± 0.3 kg) were randomly assigned to an isocaloric, lipid-, and organoleptically-matched maltodextrin placebo (PLA, n = 15), LEU (n = 14), whey protein concentrate (WPC, n = 17), whey protein hydrolysate (WPH, n = 14), or soy protein concentrate (SPC, n = 15) group...
September 4, 2017: Nutrients
https://www.readbyqxmd.com/read/28860165/influence-of-nutrient-ingestion-on-amino-acid-transporters-and-protein-synthesis-in-human-skeletal-muscle-after-sprint-exercise
#15
Håkan C Rundqvist, Mona Esbjörnsson, Olav Rooyackers, Ted Österlund, Marcus Moberg, William Apro, Eva Blomstrand, Eva Jansson
Nutrient ingestion is known to increase the exercise-induced stimulation of muscle protein synthesis following resistance exercise. Less is known about the effect of nutrients on muscle protein synthesis following sprint exercise. At two occasions separated by 1 mo, 12 healthy subjects performed three 30-s sprints with 20-min rest between bouts. In randomized order, they consumed a drink with essential amino acids and maltodextrin (nutrient) or flavored water (placebo). Muscle biopsies were obtained 80 and 200 min after the last sprint, and blood samples were taken repeatedly during the experiment...
December 1, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28669666/a-randomized-controlled-trial-on-the-efficacy-of-resistant-dextrin-as-functional-food-in-women-with-type-2-diabetes-targeting-the-hypothalamic-pituitary-adrenal-axis-and-immune-system
#16
Mahdieh Abbasalizad Farhangi, Ahmad Zare Javid, Bahareh Sarmadi, Poran Karimi, Parvin Dehghan
OBJECTIVE: The aim of this trial was to determine the efficacy of a resistant dextrin on immune-mediated inflammation and hypothalamic-pituitary-adrenal axis in women with type 2 diabetes mellitus (T2DM). METHODS: Females (n = 55) with T2DM were randomly allocated into intervention group (n = 30) and control group (n = 25), in which they received 10 g/d of Nutriose(®)06 (a resistant dextrin) or maltodextrin for 8 weeks, respectively. Fasting blood samples were taken to measure immune system related parameters like white blood cell count, CD4, CD8, interferon-γ (IFNγ), interleukins (IL12, IL4, IL10), cortisol, tryptophan (TRP), ACTH (Adrenocorticotropic hormone), Kynurenine (KYN) and plasma lipopolysaccharide (LPS) at the beginning and end of trial...
June 10, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28604135/adding-soy-protein-to-milk-enhances-the-effect-of-resistance-training-on-muscle-strength-in-postmenopausal-women
#17
Fábio L Orsatti, Nailza Maestá, Erick P de Oliveira, Jorge Nahas Neto, Roberto C Burini, Paulo R P Nunes, Aletéia P Souza, Fernanda M Martins, Eliana P Nahas
Resistance training (RT) and high-quality protein ingestion improves muscle mass (MM) and strength (MS). However, no study has evaluated the effect of ingesting milk plus soy protein (SOY) on MM and MS in postmenopausal women (PW). Thus, the aim of this study was to evaluate the effects of adding SOY to milk on MM and MS after 16 weeks of RT. Thirty-two PW were randomized and allocated into two groups: placebo and RT (PL+RT, n = 16) and SOY and RT (SOY+RT, n = 16). The SOY+RT received 25 g of SOY while the PL+RT received 25 g of maltodextrin (placebo)...
June 12, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28530448/carbohydrates-alone-or-mixing-with-beef-or-whey-protein-promote-similar-training-outcomes-in-resistance-training-males-a-double-blind-randomized-controlled-clinical-trial
#18
Fernando Naclerio, Marco Seijo-Bujia, Eneko Larumbe-Zabala, Conrad P Earnest
Beef powder is a new high-quality protein source scarcely researched relative to exercise performance. The present study examined the impact of ingesting hydrolyzed beef protein, whey protein, and carbohydrate on strength performance (1RM), body composition (via plethysmography), limb circumferences and muscular thickness (via ultrasonography), following an 8-week resistance-training program. After being randomly assigned to one of the following groups: Beef, Whey, or Carbohydrate, twenty four recreationally physically active males (n = 8 per treatment) ingested 20 g of supplement, mixed with orange juice, once a day (immediately after workout or before breakfast)...
October 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/28528092/structural-strength-analysis-of-amorphous-trehalose-maltodextrin-systems
#19
V A Maidannyk, B Nurhadi, Y H Roos
Fundamental knowledge of physical state of materials gives practically important information for food, biological and pharmaceutical industry. Based on Williams-Landel-Ferry (WLF) equation, the strength concept was introduced. This concept provides a simple parameter, S, to express resistance of solids to flow above the glass transition temperature. To develop this approach, miscible trehalose-maltodextrin (0:100; 20:80; 40:60; 60:40; 80:20 and 100:0) systems with different ratios of components were used in the present study...
June 2017: Food Research International
https://www.readbyqxmd.com/read/28492492/the-effect-of-dietary-glycemic-properties-on-markers-of-inflammation-insulin-resistance-and-body-composition-in-postmenopausal-american-women-an-ancillary-study-from-a-multicenter-protein-supplementation-trial
#20
Violeta Stojkovic, Christine A Simpson, Rebecca R Sullivan, Anna Maria Cusano, Jane E Kerstetter, Anne M Kenny, Karl L Insogna, Jessica D Bihuniak
Controversy exists as to whether high glycemic index/glycemic load (GI/GL) diets increase the risk of chronic inflammation, which has been postulated as a pathogenic intermediary between such diets and age-related alterations in body composition and insulin resistance. We conducted an ancillary study to a randomized, double-blind trial comparing the effects of a whey protein supplement (PRO, n = 38) and a maltodextrin supplement (CHO, n = 46) on bone density to evaluate the impact of a calibrated increase in GI/GL on inflammation, insulin resistance, and body composition in a healthy aging population...
May 11, 2017: Nutrients
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