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Sepsis biomarkers

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https://www.readbyqxmd.com/read/29241305/serum-glutamine-levels-as-a-potential-diagnostic-biomarker-in-sepsis-following-surgery-for-peritonitis
#1
Chun-Ju Yang, Ting-Shuo Huang, Tung-Liang Lee, Kang-Chung Yang, Shin-Sheng Yuan, Ruey-Hwa Lu, Chung-Ho Hsieh, Yu-Chiau Shyu
Few diagnostic biomarkers for sepsis after emergency peritonitis surgery are available to clinicians, and, thus, it is important to develop new biomarkers for patients undergoing this procedure. We investigated whether serum glutamine and selenium levels could be diagnostic biomarkers of sepsis in individuals recovering from emergency peritonitis surgery. From February 2012 to March 2013, patients who had peritonitis diagnosed at the emergency department and underwent emergency surgery were screened for eligibility...
December 15, 2017: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/29240645/resveratrol-downregulates-biomarkers-of-sepsis-via-inhibition-of-proteasome-s-proteases
#2
Neerupma Silswal, Nidhi S Reddy, Asaf A Qureshi, Nilofer Qureshi
LPS is the main agonist of Gram-negative bacteria and initiates inflammation. We recently reported that plasmas from sepsis patients revealed increased levels of following group of biomarkers; VCAM-1, ICAM1, CRP, resistin, and proteasome LMP subunits. Our objective here was to compare effects of resveratrol (shown to be a non-specific proteasome inhibitor by us) and a known LMP7 inhibitor (ONX-0914, specific inhibitor) on proteasome's activities, as well as on inflammatory markers mentioned above in human blood monocytes...
December 13, 2017: Shock
https://www.readbyqxmd.com/read/29239264/clinical-significance-of-plasma-presepsin-levels-in-patients-with-systemic-lupus-erythematosus
#3
Shun Tanimura, Yuichiro Fujieda, Michihiro Kono, Yuhei Shibata, Ryo Hisada, Eri Sugawara, Hiroyuki Nakamura, Kazumasa Ohmura, Sanae Shimamura, Asako Mitani, Haruki Shida, Toshiyuki Watanabe, Masaru Kato, Kenji Oku, Toshiyuki Bohgaki, Olga Amengual, Shinsuke Yasuda, Chikara Shimizu, Tatsuya Atsumi
OBJECTIVES: Presepsin (PSEP: soluble CD14 subtype) is produced from bacteria-stimulated monocytes or neutrophils, thus recognized as a biomarker of sepsis. Aberrant functions in monocyte or neutrophils are increasingly recognized in systemic lupus erythematosus (SLE). We investigated whether plasma PSEP reflects disease activity in patients with SLE. METHODS: This retrospective study comprised 35 patients with SLE and 72 with non-SLE autoimmune diseases who visited our facility during the period from August 2012 to September 2015...
December 14, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/29238336/combination-of-classifiers-identifies-fungal-specific-activation-of-lysosome-genes-in-human-monocytes
#4
João P Leonor Fernandes Saraiva, Cristina Zubiria-Barrera, Tilman E Klassert, Maximilian J Lautenbach, Markus Blaess, Ralf A Claus, Hortense Slevogt, Rainer König
Blood stream infections can be caused by several pathogens such as viruses, fungi and bacteria and can cause severe clinical complications including sepsis. Delivery of appropriate and quick treatment is mandatory. However, it requires a rapid identification of the invading pathogen. The current gold standard for pathogen identification relies on blood cultures and these methods require a long time to gain the needed diagnosis. The use of in situ experiments attempts to identify pathogen specific immune responses but these often lead to heterogeneous biomarkers due to the high variability in methods and materials used...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29236864/biomarkers-as-predictors-of-mortality-in-critically-ill-patients-with-solid-tumors
#5
Audrey M Dos Reis, Ana V G Fruchtenicht, Luiza C DE Athaydes, Sérgio Loss, Luis Fernando Moreira
Biochemical markers produced by the affected organ or body in response to disease have gained high clinical value due to assess disease development and being excellent predictors of morbidity and mortality. The aim of this study is to analyze different biochemical markers in critically cancer patients and to determine which of them can be used as predictors of mortality. This is a prospective, cross-sectional study conducted at a University Hospital in Porto Alegre - RS. Screening was done to include patients in the study...
December 11, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29234495/response-of-letter-to-the-editor-on-procalcitonin-a-promising-diagnostic-marker-for-sepsis-and-antibiotic-therapy
#6
R Saikant, Shilpa Ravindran, Ashitha Vijayan, Vani Maya, S Lakshmi, R Kartik, Manoj G
In a letter to the editor, Raineri SM et al. have given an insight of another dimension of procalcitonin (PCT) use as a diagnostic tool in invasive candidiasis. But based on our preliminary information, PCT is reported as unconventional modes of diagnosis approach which yet to prove its stand-alone biomarker properties for invasive candidiasis.
2017: Journal of Intensive Care
https://www.readbyqxmd.com/read/29226922/a-polymyxin-b-silver-nanoparticle-colloidal-system-and-the-application-of-lipopolysaccharide-analysis
#7
Tao Liu, Liqian Gao, Jing Zhao, Ya Cao, Yuguo Tang, Peng Miao
Polymyxin B (PMB) is a small cyclic polycationic lipopeptide, which can be used as an antibiotic drug against Gram-negative bacteria. In this work, the interaction between citrate capped silver nanoparticles (AgNPs) and PMB is studied. Experimental results show that the association constant is extremely high and the binding event leads to a significant variation in the localized surface plasmon resonance (LSPR) of AgNPs. Moreover, the PMB-AgNP colloidal system can be further exploited as a sensitive analytical platform...
December 11, 2017: Analyst
https://www.readbyqxmd.com/read/29225343/advances-in-the-understanding-and-treatment-of-sepsis-induced-immunosuppression
#8
REVIEW
Fabienne Venet, Guillaume Monneret
Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated host response to infection. Sepsis can induce acute kidney injury and multiple organ failures and represents the most common cause of death in the intensive care unit. Sepsis initiates a complex immune response that varies over time, with the concomitant occurrence of both pro-inflammatory and anti-inflammatory mechanisms. As a result, most patients with sepsis rapidly display signs of profound immunosuppression, which is associated with deleterious consequences...
December 11, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29212619/zinc-protoporphyrin-to-heme-ratio-and-ferritin-as-measures-of-iron-sufficiency-in-the-neonatal-intensive-care-unit
#9
Kendell German, Phuong T Vu, Kimberly N Grelli, Christopher Denton, Gina Lee, Sandra E Juul
OBJECTIVES: To evaluate ferritin and zinc protoporphyrin-to-heme (ZnPP/H) ratios as biomarkers of iron status in neonates, determine how specific clinical events affected these measures, and assess how iron status changed during hospitalization. STUDY DESIGN: We performed a retrospective study of all infants with paired ferritin and ZnPP/H measurements between October 2014 and May 2016. Concordance of these measurements, effects of sepsis, red blood cell transfusion, erythropoietin treatment, and iron supplementation were assessed...
December 4, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29212183/role-of-il-17-in-lps-induced-acute-lung-injury-an-in-vivo-study
#10
Qi Ding, Gao-Qin Liu, Yuan-Yuan Zeng, Jian-Jie Zhu, Ze-Yi Liu, Xueguang Zhang, Jian-An Huang
To assess the clinical significance of IL-17 in patients with sepsis-induced acute respiratory distress syndrome (ARDS) and to investigate the effects of IL-17 blocking in a mouse model of acute lung injury (ALI). Significantly increased IL-17 level was found in patients with sepsis-related ARDS compared to healthy controls, whereas significantly increased plasma IL-17 level was also observed in non-survivors compared to that in survivors. According to the data from the mouse ALI model, we found significantly increased IL-17 level in lung tissue lysates, mouse bronchoalveolar lavage fluid (mBALF) and plasma at 6, 12 and 24 h after ALI...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29207683/non-coding-rna-a-potential-biomarker-and-therapeutic-target-for-sepsis
#11
REVIEW
Tie-Ning Zhang, Da Li, Jing Xia, Qi-Jun Wu, Ri Wen, Ni Yang, Chun-Feng Liu
Sepsis, a syndrome of physiologic, pathologic, and biochemical abnormalities caused by an altered systemic host response to infection, has become the main cause of death among patients admitted to the intensive care units. Recently, genome-wide expression analysis revealed that over 80% of the essential genetic elements were altered in critically ill patients. Notably, non-coding RNAs, including microRNAs, long non-coding RNAs and circular RNAs, have been proven to play essential roles in innate immunity, mitochondrial dysfunction and organ dysfunction...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29205640/presepsin-as-a-predictor-of-positive-blood-culture-among-newborns-suspected-sepsis
#12
Yukihide Miyosawa, Yohei Akazawa, Motoko Kamiya, Chizuko Nakamura, Yusuke Takeuchi, Mai Kusakari, Tomohiko Nakamura
BACKGROUND: Although the incidence of neonatal sepsis is decreasing, neonatal sepsis remains a severe life-threatening disease. No current biochemical marker can provide perfect diagnostic accuracy for neonatal sepsis. OBJECTIVES: We evaluated the accuracy of presepsin (P-SEP) as a novel biomarker of bacterial infection for neonatal sepsis diagnosis. METHODS: We prospectively studied newborns with sepsis (sepsis group n=13) during the first 30 days after birth and compared them with control preterm newborns (control group n=18)...
December 5, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29204871/bone-marrow-mesenchymal-stem-cells-combat-lipopolysaccharide-induced-sepsis-in-rats-via-amendment-of-p38-mapk-signaling-cascade
#13
Omnia S Zaki, Marwa M Safar, Afaf A Ain-Shoka, Laila A Rashed
Sepsis is a systemic inflammatory disorder which often occurs during extremely stressful conditions such as trauma, burn, shock, and infection. This study investigated the curative effects of bone marrow-derived mesenchymal stem cells (BM-MSCs) against hepatic, renal, and pulmonary responses caused by a single administration of lipopolysaccharide (LPS) (10 mg/kg, i.p) in rats. Treatment with BM-MSCs (5 × 105 in 0.1 ml PBS, i.p.) 3 h after LPS antagonized the LPS-induced increment of the liver enzymes (ALT, AST) and kidney functions (BUN, sCr)...
December 4, 2017: Inflammation
https://www.readbyqxmd.com/read/29204105/treatment-with-24%C3%A2-h-delayed-normo-and-hyperbaric-oxygenation-in-severe-sepsis-induced-by-cecal-ligation-and-puncture-in-rats
#14
Nina Falcon Bærnthsen, Marco Bo Hansen, Anna Mygind Wahl, Ulf Simonsen, Ole Hyldegaard
Background: Septic shock remains a leading cause of death worldwide. Hyperbaric oxygen treatment (HBO2) has been shown to alter the inflammatory response during sepsis and to reduce mortality. A therapeutic window of HBO2 treatment has been demonstrated experimentally, but optimal timing remains uncertain. We investigated the effects of 24 h delayed normobaric oxygen (NBO2) and HBO2 treatment on the endogenous production of the inflammatory markers interleukin (IL)-6, tumor necrosis factor (TNF)-α and IL-10, and on mortality in rats with cecal ligation and puncture (CLP) induced sepsis...
2017: Journal of Inflammation
https://www.readbyqxmd.com/read/29200137/early-prediction-of-persistent-organ-failure-by-circulating-endothelial-progenitor-cells-in-patients-with-acute-pancreatitis
#15
Jun Liu, Gui-Juan Zou, Long Yang, Shu Rong, Bai-Qiang Li, Zhi-Hui Tong, Wei-Qin Li, Jie-Shou Li
INTRODUCTION: Increased circulating endothelial progenitor cells (cEPC) have been observed in patients with vascular injury associated with sepsis and acute lung injury. However, a role for cEPC in severe acute pancreatitis (SAP) remains unclear. We therefore conducted a prospective study to study whether the quantities of cEPC can predict persistent organ failure (POF) in patients with predicted SAP. METHODS: A total of 42 predicted SAP patients who were admitted within 24 hours after symptom onset and 10 healthy control subjects were enrolled in our study...
December 1, 2017: Shock
https://www.readbyqxmd.com/read/29198774/serum-melatonin-levels-during-the-first-seven-days-of-severe-sepsis-diagnosis-are-associated-with-sepsis-severity-and-mortality
#16
Leonardo Lorente, María M Martín, Pedro Abreu-González, Antonia Pérez-Cejas, Raquel Ortiz López, José Ferreres, Jordi Solé-Violán, Lorenzo Labarta, César Díaz, Celina Llanos, Alejandro Jiménez
OBJECTIVE: Higher serum melatonin levels have previously been found in patients with severe sepsis who died within 30 days of diagnosis than in survivors. The objective of our study were to determine whether serum melatonin levels during the first seven days of severe sepsis diagnosis could be associated with sepsis severity and mortality. METHODS: Multicentre study in eight Spanish Intensive Care Units which enrolled 308 patients with severe sepsis. We determined serum levels of melatonin, malondialdehyde (as biomarker of lipid peroxidation) and tumor necrosis factor-alpha at days 1, 4 and 8 of severe sepsis diagnosis...
November 30, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29185950/procalcitonin-and-neonatal-sepsis-is-this-the-biomarker-we-are-looking-for
#17
Susan Givens Bell
Researchers estimate the incidence of early onset sepsis as 0.77-1/1,000 live births. It remains as one of the leading causes of neonatal deaths. Clinicians and researchers continue to search for biomarkers for specific neonatal disease processes. Clinicians frequently trend C-reactive protein levels during evaluation for neonatal sepsis. Recently, researchers have begun to explore procalcitonin as a potentially useful diagnostic marker for neonatal sepsis.
November 1, 2017: Neonatal Network: NN
https://www.readbyqxmd.com/read/29180833/growth-differentiation-factor-15-is-a-predictor-of-mortality-in-critically-ill-patients-with-sepsis
#18
Lukas Buendgens, Eray Yagmur, Jan Bruensing, Ulf Herbers, Christer Baeck, Christian Trautwein, Alexander Koch, Frank Tacke
Growth differentiation factor-15 (GDF-15) is a member of the transforming growth factor-β superfamily related to inflammation and macrophage activation. Serum concentrations of GDF-15 can predict poor survival in chronic diseases, but its role in sepsis is obscure. Therefore, we investigated GDF-15 as a prognostic biomarker in critically ill patients. We measured GDF-15 levels in 219 critically ill patients (146 with sepsis, 73 without sepsis) upon admission to the intensive care unit (ICU), in comparison to 66 healthy controls...
2017: Disease Markers
https://www.readbyqxmd.com/read/29176018/diagnostic-and-prognostic-value-of-presepsin-vs-established-biomarkers-in-critically-ill-patients-with-sepsis-or-systemic-inflammatory-response-syndrome
#19
Helena Brodska, Jiri Valenta, Kveta Pelinkova, Zdenek Stach, Robert Sachl, Martin Balik, Tomas Zima, Tomas Drabek
BACKGROUND: Inflammatory biomarkers may aid to distinguish between systemic inflammatory response syndrome (SIRS) vs. sepsis. We tested the hypotheses that (1) presepsin, a novel biomarker, can distinguish between SIRS and sepsis, and (2) higher presepsin levels will be associated with increased severity of illness and (3) with 28-day mortality, outperforming traditional biomarkers. METHODS: Procalcitonin (PCT), C-reactive protein (CRP), presepsin, and lactate were analyzed in 60 consecutive patients (sepsis and SIRS, n=30 per group) on day 1 (D1) to D3 (onset sepsis, or after cardiac surgery)...
November 25, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29175046/serum-anion-gap-predicts-lactate-poorly-but-may-be-used-to-identify-sepsis-patients-at-risk-for-death-a-cohort-study
#20
Nicholas M Mohr, J Priyanka Vakkalanka, Brett A Faine, Brian Skow, Karisa K Harland, Ryan Dick-Perez, Brian M Fuller, Azeemuddin Ahmed, Steven Q Simson
PURPOSE: (1) To test whether serum bicarbonate or anion gap can be used to predict elevated lactate or mortality in emergency department (ED) patients with sepsis, and (2) to define thresholds that may predict elevated lactate and mortality. METHODS: Retrospective diagnostic-validation study of adults with sepsis treated in a 60,000-visit Midwestern university ED (2010-2015). In the derivation sample, 8 experts selected thresholds based on objective measures to optimize clinical utility...
October 31, 2017: Journal of Critical Care
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