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https://www.readbyqxmd.com/read/29148568/intrathecal-baclofen-in-dyskinetic-cerebral-palsy-effects-on-function-and-activity
#1
Meta N Eek, Kristina Olsson, Karin Lindh, Berit Askljung, Magnus Påhlman, Olle Corneliusson, Kate Himmelmann
AIM: To investigate the effect of intrathecal baclofen (ITB) on function and activity in dyskinetic cerebral palsy (CP). METHOD: A retrospective cohort study of records from 25 children (15 males, 10 females; mean age 10y 11mo, SD 4y 9mo). Five were classified in Gross Motor Function Classification level IV and 20 in level V. Parents were interviewed about activities in daily life, sitting, communication, pain, sleep, and gross and fine motor function. Differences before and 1 year after ITB were graded as positive, no change, or negative...
November 17, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29147730/on-the-skilled-plantar-flexor-motor-action-and-unique-electromyographic-activity-of-ballet-dancers
#2
Sakiko Saito, Hiroki Obata, Mayumi Kuno-Mizumura, Kimitaka Nakazawa
The study aimed to compare the ability of dance and non-dance subjects to perform fine control of a simple heel-raising/lowering movement, and to determine if there are any differences in motor unit activity in the primary plantar flexor muscles during the movement. Subjects were instructed to accurately track a sinusoidal trace with a heel-raising and lowering movement at four controlled frequencies (1, 0.5, 0.25, and 0.125 Hz). The ankle joint angle was used to characterize movement errors from the target...
November 16, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29136419/occupational-exposure-to-manganese-and-fine-motor-skills-in-elderly-men-results-from-the-heinz-nixdorf-recall-study
#3
Beate Pesch, Swaantje Casjens, Tobias Weiss, Benjamin Kendzia, Marina Arendt, Lewin Eisele, Thomas Behrens, Nadin Ulrich, Noreen Pundt, Anja Marr, Sibylle Robens, Christoph Van Thriel, Rainer Van Gelder, Michael Aschner, Susanne Moebus, Nico Dragano, Thomas Brüning, Karl-Heinz Jöckel
Objectives: Exposure to manganese (Mn) may cause movement disorders, but less is known whether the effects persist after the termination of exposure. This study investigated the association between former exposure to Mn and fine motor deficits in elderly men from an industrial area with steel production. Methods: Data on the occupational history and fine motor tests were obtained from the second follow-up of the prospective Heinz Nixdorf Recall Study (2011-2014)...
November 10, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/29133437/abnormal-microglia-and-enhanced-inflammation-related-gene-transcription-in-mice-with-conditional-deletion-of-ctcf-in-camk2a-cre-expressing-neurons
#4
Bryan E McGill, Ruteja A Barve, Susan E Maloney, Amy Strickland, Nicholas Rensing, Peter Wang, Michael Wong, Richard Head, David F Wozniak, Jeffrey Milbrandt
CCCTC-binding factor (CTCF) is an 11 zinc finger DNA-binding domain protein that regulates gene expression by modifying three dimensional chromatin structure. Human mutations in CTCF cause intellectual disability and autistic features. Knocking out Ctcf in mouse embryonic neurons is lethal by neonatal age, but the effects of CTCF deficiency in postnatal neurons are less well studied. We knocked out Ctcf postnatally in glutamatergic forebrain neurons under the control of Camk2a-CreCtcf(loxP/loxP) ;Camk2a-Cre+ (Ctcf CKO) mice of both sexes were viable and exhibited profound deficits in spatial learning/memory, impaired motor co-ordination, and decreased sociability by 4 months of age...
November 13, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29126862/cortical-activity-in-fine-motor-tasks-in-children-with-developmental-coordination-disorder-a-preliminary-fnirs-study
#5
Priscila Caçola, Nancy Getchell, Dhivya Srinivasan, Georgios Alexandrakis, Hanli Liu
Developmental Coordination Disorder (DCD) is as a neurodevelopmental condition characterized by poor motor proficiency, which impacts academic performance and activities of daily living. Several studies have determined that children with DCD activate different regions of the brain when performing motor skills in comparison to typically developing (TD) children. However, none have used Functional Near-Infrared Spectroscopy (fNIRS) to explore cortical activation in this population. With that, the goal of this preliminary study was to investigate cortical activation using fNIRS in six children with DCD and six TD children between ages of 8 and 12 years...
November 7, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29125508/urologic-self-management-through-intermittent-self-catheterization-among-individuals-with-spina-bifida-a-journey-to-self-efficacy-and-autonomy
#6
Jonathan Castillo, Kathryn K Ostermaier, Ellen Fremion, Talia Collier, Huirong Zhu, Gene O Huang, Duong Tu, Heidi Castillo
PURPOSE: To describe the age of independence in intermittent self-catheterization (ISC) in a diverse patient population and identify factors associated with ISC in individuals with spina bifida. METHODS: Two hundred patients with myelomeningocele or lipomyelomeningocele, who were ⩾ 3 years of age and utilized catheterization for bladder management were included. Data regarding diagnosis, functional level of lesion, race, ethnicity, presence of shunt, method of catheterization, self-management skills, fine motor skills, and cognitive abilities were collected...
October 20, 2017: Journal of Pediatric Rehabilitation Medicine
https://www.readbyqxmd.com/read/29121516/comparing-motor-performance-praxis-coordination-and-interpersonal-synchrony-between-children-with-and-without-autism-spectrum-disorder-asd
#7
Maninderjit Kaur, Sudha M Srinivasan, Anjana N Bhat
Children with Autism Spectrum Disorder (ASD) have basic motor impairments in balance, gait, and coordination as well as autism-specific impairments in praxis/motor planning and interpersonal synchrony. Majority of the current literature focuses on isolated motor behaviors or domains. Additionally, the relationship between cognition, symptom severity, and motor performance in ASD is unclear. We used a comprehensive set of measures to compare gross and fine motor, praxis/imitation, motor coordination, and interpersonal synchrony skills across three groups of children between 5 and 12 years of age: children with ASD with high IQ (HASD), children with ASD with low IQ (LASD), and typically developing (TD) children...
November 6, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29110618/cognitive-effects-of-nicotine-recent-progress
#8
Gerald Valentine, Mehmet Sofuoglu
Cigarette smoking is the main cause of preventable death in developed countries. Given the limited effectiveness of currently available treatments, there is a great need to identify new treatment approaches for tobacco use disorder (TUD). While the direct positive behavioral reinforcing effect of nicotine has historically been considered the primary mechanism driving the development of TUD, accumulating contemporary research suggests that the cognitive-enhancing effects of nicotine may also significantly contribute to the initiation and maintenance of TUD, especially in individuals with pre-existing cognitive deficits...
November 3, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/29108966/dual-task-of-fine-motor-skill-and-problem-solving-in-individuals-with-multiple-sclerosis-a-pilot-study
#9
Y Goverover, B M Sandroff, J DeLuca
OBJECTIVE: To examine and compare dual-task performance in patients with Multiple Sclerosis (MS) and healthy controls (HC) using mathematical problem-solving questions that included an everyday competence component while performing an upper extremity fine motor task. Additionally, it examined whether difficulties in dual-task performance are associated with problems in performing an everyday internet task. DESIGN: Pilot study, mixed-design with both a within and between subjects' factor PARTICIPANTS: and Setting: Participants included 19 persons with MS and 19 HC who were recruited from a nonprofit rehabilitation research institution and from the community...
November 3, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29107829/evaluating-rodent-motor-functions-which-tests-to-choose
#10
REVIEW
Lisa-Maria Schönfeld, Dearbhaile Dooley, Ali Jahanshahi, Yasin Temel, Sven Hendrix
Damage to the motor cortex induced by stroke or traumatic brain injury (TBI) can result in chronic motor deficits. For the development and improvement of therapies, animal models which possess symptoms comparable to the clinical population are used. However, the use of experimental animals raises valid ethical and methodological concerns. To decrease discomfort by experimental procedures and to increase the quality of results, non-invasive and sensitive rodent motor tests are needed. A broad variety of rodent motor tests are available to determine deficits after stroke or TBI...
October 28, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29096181/improvement-in-children-s-fine-motor-skills-following-a-computerized-typing-intervention
#11
Hannah L McGlashan, Caroline C V Blanchard, Nicole J Sycamore, Rachel Lee, Blandine French, Nicholas P Holmes
Children spend a large proportion of their school day engaged in tasks that require manual dexterity. If children experience difficulties with their manual dexterity skills it can have a consequential effect on their academic achievement. The first aim of this paper was to explore whether an online interactive typing intervention could improve children's scores on a standardised measure of manual dexterity. The second aim was to implement a serial reaction time tapping task as an index of children's finger movement learning, and to see whether performance on this task would improve after the intervention...
October 31, 2017: Human Movement Science
https://www.readbyqxmd.com/read/29096178/association-between-fine-motor-skills-and-binocular-visual-function-in-children-with-reading-difficulties
#12
Ewa Niechwiej-Szwedo, Fatimah Alramis, Lisa W Christian
Performance of fine motor skills (FMS) assessed by a clinical test battery has been associated with reading achievement in school-age children. However, the nature of this association remains to be established. The aim of this study was to assess FMS in children with reading difficulties using two experimental tasks, and to determine if performance is associated with reduced binocular function. We hypothesized that in comparison to an age- and sex-matched control group, children identified with reading difficulties will perform worse only on a motor task that has been shown to rely on binocular input...
October 27, 2017: Human Movement Science
https://www.readbyqxmd.com/read/29071796/counting-on-fine-motor-skills-links-between-preschool-finger-dexterity-and-numerical-skills
#13
Ursula Fischer, Sebastian P Suggate, Judith Schmirl, Heidrun Stoeger
Finger counting is widely considered an important step in children's early mathematical development. Presumably, children's ability to move their fingers during early counting experiences to aid number representation depends in part on their early fine motor skills (FMS). Specifically, FMS should link to children's procedural counting skills through consistent repetition of finger-counting procedures. Accordingly, we hypothesized that (a) FMS are linked to early counting skills, and (b) greater FMS relate to conceptual counting knowledge (e...
October 26, 2017: Developmental Science
https://www.readbyqxmd.com/read/29070031/17q23-2q23-3-de-novo-duplication-in-association-with-speech-and-language-disorder-learning-difficulties-incoordination-motor-skill-impairment-and-behavioral-disturbances-a-case-report
#14
Karen Wessel, Jehan Suleiman, Tamam E Khalaf, Shivendra Kishore, Arndt Rolfs, Ayman W El-Hattab
BACKGROUND: Chromosomal rearrangements involving 17q23 have been described rarely. Deletions at 17q23.1q23.2 have been reported in individuals with developmental delay and growth retardation, whereas duplications at 17q23.1q23.2 appear to segregate with clubfoot. Dosage alterations in the TBX2 and TBX4 genes, located in 17q23.2, have been proposed to be responsible for the phenotypes observed in individuals with 17q23.1q23.2 deletions and duplications. In this report, we present the clinical phenotype of a child with a previously unreported de novo duplication at 17q23...
October 25, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/29065345/myelin-dynamics-protecting-and-shaping-neuronal-functions
#15
REVIEW
Aiman S Saab, Klaus-Armin Nave
Myelinating glial cells are well-known to insulate axons and to speed up action potential propagation. Through adjustments in the axonal coverage with myelin, myelin sheath thickness and possibly nodal/internode length oligodendrocytes are involved in fine-tuning the brain's computational power throughout life. Be it motor skill learning or social behaviors in higher vertebrates, proper myelination is critical in shaping brain functions. Neurons rely on their myelinating partners not only for setting conduction speed, but also for regulating the ionic environment and fueling their energy demands with metabolites...
October 21, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/29065156/motor-skill-delays-in-pre-school-children-with-leukemia-one-year-after-treatment-hematopoietic-stem-cell-transplantation-therapy-as-an-important-risk-factor
#16
Livia Taverna, Marta Tremolada, Sabrina Bonichini, Barbara Tosetto, Giuseppe Basso, Chiara Messina, Marta Pillon
CNS-directed therapies for the treatment of leukemia can adversely affect the acquisition of new skills, such as reading/writing and math. Two years after the end of treatments, children show gross and fine motor skill delays that may persist even when patients are considered healed. The goal of the present study was to assess motor skills difficulties in pre-school children with leukemia one year after treatment. Particular attention has been paid to those patients who had undergone Hematopoietic Stem Cell Transplantation (HSCT) and to the relationship between motor delays and age bands...
2017: PloS One
https://www.readbyqxmd.com/read/29064292/psychophysiological-response-and-fine-motor-skills-in-high-altitude-parachute-jumps
#17
Vicente Javier Clemente-Suárez, José Juan Robles-Pérez, Ketty Herrera-Mendoza, Beliña Herrera-Tapias, Jesús Fernández-Lucas
Clemente-Suárez, Vicente Javier, José Juan Robles-Pérez, Ketty Herrera-Mendoza, Beliña Herrera-Tapias, and Jesús Fernández-Lucas. Psychophysiological response and fine motor skills in high-altitude parachute jumps. High Alt Med Biol 00:000-000, 2017.-We analyzed the psychophysiological response and specific fine motor skill of an experienced jumper in HALO (high altitude low opening) and HAHO (high altitude high opening) parachute jumps. Eight HALO and eight HAHO jumpers were analyzed. They jumped at 5500 m, HALO jumpers opened the parachute at 500 m and HAHO jumpers at 4300 m of altitude...
October 24, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29060181/a-new-hand-function-assessment-method-using-an-infrared-imaging-device
#18
Qinag Fang, Xudong Gu
Many post-stroke patients suffer various degrees of hand function and fine motor skills impairment. Both passive and active hand rehabilitation training are beneficial in improving strength and dexterity of hands. However, hand rehabilitation programs should be prescribed, based on an accurate assessment of hand function. Here we propose a novel method for hand function assessment that can accurately measure multiple joint angles of a hand simultaneously using a portable infrared imaging device. Different from the traditional assessment methods that are often based on clinicians' subjective observation and ordinal charts, this method provides an accurate, fast and objective evaluation using infrared imaging sensors...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29045480/quantitative-assessment-of-finger-motor-performance-normative-data
#19
Alessio Signori, Maria Pia Sormani, Irene Schiavetti, Ambra Bisio, Marco Bove, Laura Bonzano
BACKGROUND: Finger opposition movements are the basis of many daily living activities and are essential in general for manipulating objects; an engineered glove quantitatively assessing motor performance during sequences of finger opposition movements has been shown to be useful to provide reliable measures of finger motor impairment, even subtle, in subjects affected by neurological diseases. However, the obtained behavioral parameters lack published reference values. OBJECTIVE: To determine mean values for different motor behavioral parameters describing the strategy adopted by healthy people in performing repeated sequences of finger opposition movements, examining associations with gender and age...
2017: PloS One
https://www.readbyqxmd.com/read/29032428/usability-operations-on-touch-mobile-devices-for-users-with-autism
#20
Angeles Quezada, Reyes Juárez-Ramírez, Samantha Jiménez, Alan Ramírez Noriega, Sergio Inzunza, Arnulfo Alanis Garza
The Autistic Spectrum Disorder is a cognitive disorder that affects the cognitive and motor skills; due that, users cannot perform digital and fine motor tasks. It is necessary to create software applications that adapt to the abilities of these users. In recent years has been an increase in the research of the use of technology to support autistic users to develop their communication skills and to improve learning. However, the applications' usability for disable users is not assessed objectively as the existing models do not consider interaction operators for disable users...
October 14, 2017: Journal of Medical Systems
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