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https://www.readbyqxmd.com/read/28811814/apert-syndrome-report-of-a-rare-congenital-malformation
#1
Ehsan Rathore, Altaf Hussain Rathore
A rare case of an adult male with malformation of the skull, face, hands and feet called acrocephalosyndactly or Apert syndrome is presented. Its probable cause, features and treatment is discussed. It is a unique case who survived upto the age of 32 years without any operative intervention and adjusted in the society though he has all the stigmas of the above syndrome. We have concluded and made a point that in the adult sufferer, facial deformity is not so important and urgent for the treatment than syndactyly, which handicaps the sufferer in performing the daily routine work...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28808545/dioecious-plants-are-more-precocious-than-cosexual-plants-a-comparative-study-of-relative-sizes-at-the-onset-of-sexual-reproduction-in-woody-species
#2
Itsuki Ohya, Satoshi Nanami, Akira Itoh
The reproductive capacities of dioecious plant species may be limited by severe pollen limitation and narrow seed shadows for the two reasons. First, they are unable to self-pollinate, and seed production occurs only with pollinator movement from males to females. Second, only 50% of the individuals in populations contribute to seed production. Despite these handicaps, dioecious plants maintain their populations in plant communities with cooccurring cosexual plants, and no substantial difference in population growth rates has been found between dioecious and cosexual plants...
August 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28802393/paediatric-injection-medialisation-laryngoplasty-recent-great-ormond-street-hospital-experience
#3
K A Stephenson, L Cavalli, A Lambert, J Fleming, E Lawes, S Gupta, C G Jephson, L A Cochrane
INTRODUCTION: Unilateral vocal fold paresis may significantly impair the vocal quality and laryngeal competence of a child. Relatively little literature relates to injection medialisation laryngoplasty (IML) in children and previous reports have involved small numbers of heterogenous cases. METHODS: A retrospective review was conducted of paediatric patients managed by our multidisciplinary specialist voice clinic undergoing IML for unilateral vocal fold paresis...
September 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28799223/a-structural-equation-model-to-assess-the-influence-of-neuroticism-on-oral-health-related-quality-of-life-in-complete-denture-wearers
#4
Hitomi Soeda, Yusuke Sato, Eijiro Yamaga, Shunsuke Minakuchi
OBJECTIVE: To investigate the influence of patient neuroticism on oral health-related quality of life (OHRQoL) in complete denture wearers. BACKGROUND: There are some indicators of complete denture prognosis. The relationship between personality traits, mainly neuroticism and OHRQoL in complete denture wearers remains unclear. MATERIALS AND METHODS: A total of 199 edentulous patients participated in this study. Neuroticism was investigated using the Japanese version of the modified short form of the Eysenck Personality Questionnaire (MS-EPQ)...
August 10, 2017: Gerodontology
https://www.readbyqxmd.com/read/28798674/adaptive-gaze-strategies-for-locomotion-with-constricted-visual-field
#5
Colas N Authié, Alain Berthoz, José-Alain Sahel, Avinoam B Safran
In retinitis pigmentosa (RP), loss of peripheral visual field accounts for most difficulties encountered in visuo-motor coordination during locomotion. The purpose of this study was to accurately assess the impact of peripheral visual field loss on gaze strategies during locomotion, and identify compensatory mechanisms. Nine RP subjects presenting a central visual field limited to 10-25° in diameter, and nine healthy subjects were asked to walk in one of three directions-straight ahead to a visual target, leftward and rightward through a door frame, with or without obstacle on the way...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28798261/confounding-by-pre-morbid-functional-status-in-studies-of-apparent-sex-differences-in-severity-and-outcome-of-stroke
#6
Christel Renoux, Janie Coulombe, Linxin Li, Aravind Ganesh, Louise Silver, Peter M Rothwell
BACKGROUND AND PURPOSE: Several studies have reported unexplained worse outcomes after stroke in women but none included the full spectrum of symptomatic ischemic cerebrovascular events while adjusting for prior handicap. METHODS: Using a prospective population-based incident cohort of all transient ischemic attack/stroke (OXVASC [Oxford Vascular Study]) recruited between April 2002 and March 2014, we compared pre-morbid and post-event modified Rankin Scale score (mRS) in women and men and change in mRS score 1 month, 6 months, 1 year, and 5 years after stroke...
August 10, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28793136/an-exploration-of-the-associations-among-hearing-loss-physical-health-and-visual-memory-in-adults-from-west-central-alabama
#7
Marcia J Hay-McCutcheon, Adriana Hyams, Xin Yang, Jason Parton, Brianna Panasiuk, Sarah Ondocsin, Mary Margaret James, Forrest Scogin
Purpose: The purpose of this preliminary study was to explore the associations among hearing loss, physical health, and visual memory in adults living in rural areas, urban clusters, and an urban city in west Central Alabama. Method: Two hundred ninety-seven adults (182 women, 115 men) from rural areas, urban clusters, and an urban city of west Central Alabama completed a hearing assessment, a physical health questionnaire, a hearing handicap measure, and a visual memory test...
August 9, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28791468/functional-outcomes-of-endoscopic-arytenoid-abduction-lateropexy-for-unilateral-vocal-cord-paralysis-with-dyspnea
#8
Vera Matievics, Adam Bach, Balazs Sztano, Zsofia Bere, Zoltan Tobias, Paul F Castellanos, Andreas H Mueller, Laszló Rovo
In unilateral vocal cord paralysis (UVCP), hoarseness is usually the leading symptom; however, the diminished airway might lead to breathing problems as well, especially with exertion. The application of the classic resection glottis enlarging or medialization procedures might shift the breathing and/or the voice to a worse condition. The non-destructive endoscopic arytenoid abduction lateropexy (EAAL) might be a solution for this problem. The aim of our study was to analyze the phonatory and respiratory outcomes of this treatment concept...
August 8, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28791330/computer-assisted-instruction-before-colonoscopy-is-as-effective-as-nurse-counselling-a-clinical-pilot-trial
#9
Govert Veldhuijzen, Michael Klemt-Kropp, Casper Noomen, Aura A Van Esch, Eric T Tjwa, Joost Drenth
BACKGROUND AND STUDY AIMS:  Better patient education prior to colonoscopy improves adherence to instructions for bowel preparation and leads to cleaner colons. We reasoned that computer assisted instruction (CAI) using video and 3 D animations followed by nurse contact maximizes the effectiveness of nurse counselling, increases proportion of clean colons and improves patient experience. PATIENTS AND METHODS:  Adults referred for colonoscopy in a high-volume endoscopy unit in the Netherlands were included...
August 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28781953/endoglucanase-activity-at-a-second-site-in-pyrococcus-furiosus-triosephosphate-isomerase-promiscuity-or-compensation-for-a-metabolic-handicap
#10
Prerna Sharma, Purnananda Guptasarma
The eight-stranded (β/α)8 barrel fold known as the Triosephosphate isomerase (TIM) barrel is the most commonly observed fold in enzymes, displaying an eightfold structural symmetry. The sequences and structures of different TIM barrel enzymes suggest that nature exploits the modularity inherent in the eightfold symmetry to generate enzymes with diverse enzymatic activities and, in certain cases, more than one catalytic activity per enzyme. Here, we report the discovery, verification, and characterization of such an additional activity, a novel endoglucanase/cellulase activity in what is otherwise a triosephosphate isomerase from the hyperthermophile archaeon Pyrococcus furiosus (PfuTIM)...
August 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/28780767/ageing-successfully-with-haemophilia-a-multidisciplinary-programme
#11
E Boccalandro, M E Mancuso, S Riva, D M Pisaniello, F Ronchetti, E Santagostino, F Peyvandi, L P Solimeno, P M Mannucci, G Pasta
INTRODUCTION: Persons with haemophilia (PWH) born before the middle 1970s have spent a substantial part of their lives without the benefits of replacement therapy, that became available on a relative large scale only during the 1970s. As a consequence, this group of PWH, although still relatively young, suffers from musculoskeletal and functional problems that are typical of old people. METHODS: We report herewith the short-term results of a project based upon a multidisciplinary training programme led by a physiotherapist and an occupational therapist, that was implemented over a period of 12 months in 40 patients with severe or moderate hemophilia A or B born before the middle 1970s and regularly followed-up at a comprehensive haemophilia treatment centre in Italy...
August 6, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/28777127/antivertiginous-drug-therapy-does-not-hinder-the-efficacy-of-individualized-vibrotactile-neurofeedback-training-for-vestibular-rehabilitation-a-randomized-trial
#12
Dietmar Basta, Liliana Borsellino, Arne Ernst
Vestibular rehabilitation using individualized vibrotactile neurofeedback training (IVNT) can lead to significant improvement in the postural stability of patients with vestibular symptoms of different origins. However, some of these patients have complex, severe dizziness, meaning that a pharmacological pretreatment or parallel (to vestibular rehabilitation) treatment can help them perform the rehabilitation exercises. Hence, the present study investigated the influence of a pharmacological treatment on the efficacy of vibrotactile neurofeedback training in patients with chronic, noncompensated vestibulopathies...
August 2, 2017: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/28775256/a-genome-wide-association-study-identified-a-novel-genetic-loci-ston1-gtf2a1l-lhcgr-fshr-for-bilaterality-of-neovascular-age-related-macular-degeneration
#13
Kyoko Kawashima-Kumagai, Kenji Yamashiro, Munemitsu Yoshikawa, Masahiro Miyake, Gemmy Cheung Chui Ming, Qiao Fan, Jia Yu Koh, Masaaki Saito, Masako Sugahara-Kuroda, Maho Oishi, Yumiko Akagi-Kurashige, Isao Nakata, Hideo Nakanishi, Norimoto Gotoh, Akio Oishi, Hiroshi Tamura, Sotaro Ooto, Akitaka Tsujikawa, Yasuo Kurimoto, Tetsuju Sekiryu, Fumihiko Matsuda, Chiea-Chuen Khor, Ching-Yu Cheng, Tien Yin Wong, Nagahisa Yoshimura
Bilateral neovascular age-related macular degeneration (AMD) causes much more handicaps for patients than unilateral neovascular AMD. Although several AMD-susceptibility genes have been evaluated for their associations to bilaterality, genome-wide association study (GWAS) on bilaterality has been rarely reported. In the present study, we performed GWAS using neovascular AMD cases in East Asian. The discovery stage compared 581,252 single nucleotide polymorphisms (SNPs) between 803 unilateral and 321 bilateral Japanese cases but no SNP showed genome-wide significance, while SNPs at six regions showed P-value < 1...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28772303/effect-of-vitamin-d-deficiency-on-voice
#14
Abdul-Latif Hamdan, Georges Ziade, Doja Sarieddine, Dollen Tabri, Fatima Allaw, Rachel Btaiche, Sami Azar
Purpose: The purpose of this article was to investigate the relationship between low level of vitamin D, phonatory symptoms, and acoustic findings. Method: A total of 38 subjects presenting to the endocrinology clinic were enrolled in 2 groups: 19 with vitamin D deficiency who were not on treatment, and 19 with normal vitamin D level who were on treatment. Demographic data included age, gender, and history of smoking. All patients were asked about the presence or absence of dysphonia, degree of phonatory effort, and vocal fatigue...
August 15, 2017: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28770347/web-thickness-determines-the-therapeutic-effect-of-endoscopic-keel-placement-on-anterior-glottic-web
#15
Jian Chen, Fang Shi, Min Chen, Yue Yang, Lei Cheng, Haitao Wu
This work is a retrospective analysis to investigate the critical risk factor for the therapeutic effect of endoscopic keel placement on anterior glottic web. Altogether, 36 patients with anterior glottic web undergoing endoscopic lysis and silicone keel placement were enrolled. Their voice qualities were evaluated using the voice handicap index-10 (VHI-10) questionnaire, and improved significantly 3 months after surgery (21.53 ± 3.89 vs 9.81 ± 6.68, P < 0.0001). However, 10 (27.8%) cases had web recurrence during the at least 1-year follow-up...
August 2, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28770008/overexpression-of-serine-protease-htra-enhances-disruption-of-adherens-junctions-paracellular-transmigration-and-type-iv-secretion-of-caga-by-helicobacter-pylori
#16
Aileen Harrer, Manja Boehm, Steffen Backert, Nicole Tegtmeyer
BACKGROUND: The serine protease HtrA is an important factor for regulating stress responses and protein quality control in bacteria. In recent studies, we have demonstrated that the gastric pathogen Helicobacter pylori can secrete HtrA into the extracellular environment, where it cleaves-off the ectodomain of the tumor suppressor and adherens junction protein E-cadherin on gastric epithelial cells. RESULTS: E-cadherin cleavage opens cell-to-cell junctions, allowing paracellular transmigration of the bacteria across polarized monolayers of MKN-28 and Caco-2 epithelial cells...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/28762346/prevalence-of-traumatic-dental-injuries-among-visually-impaired-children-attending-special-schools-of-chhattisgarh
#17
Harsha Munot, Alok Avinash, Nilotpol Kashyap, Rashmi Baranwal, Brij Kumar, Maylavarapu Krishna Sagar
BACKGROUND: Studies on dental trauma of the normal population have been carried out in the past; however, limited data are available on dental trauma of the handicapped population, especially visually impaired children in Chhattisgarh, India. AIM: The aim of this study is to determine the prevalence of traumatic dental injuries (TDIs) in visually impaired children in relation to age, cause, and place of injury. MATERIALS AND METHODS: Epidemiological study was carried out among 400 children from various special schools of visually impaired children of Chhattisgarh followed by school dental checkup camps...
July 2017: Journal of the Indian Society of Pedodontics and Preventive Dentistry
https://www.readbyqxmd.com/read/28760537/randomized-double-blind-trial-of-amitriptyline-versus-placebo-in-treatment-of-chronic-laryngopharyngeal-neuropathy
#18
Minyoung Jang, Samuel J Rubin, Daniel J Stein, Jacob Pieter Noordzij
OBJECTIVE: A neuropathic etiology has been suggested for patients with chronic laryngopharyngitis symptoms without visible structural pathology. Prior studies have shown that treatment with neuro-modulating medications is beneficial, but it is unknown if this was due to placebo effect. Our objective was to compare the efficacy of amitriptyline versus placebo in treating chronic laryngopharyngeal neuropathy. STUDY DESIGN: Prospective, randomized placebo-controlled trial...
July 12, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28760382/identifying-knowledge-gaps-in-clinicians-who-evaluate-and-treat-vocal-performing-artists-in-college-health-settings
#19
Leah McKinnon-Howe, Jayme Dowdall
OBJECTIVE: The goal of this study was to identify knowledge gaps in clinicians who evaluate and treat performing artists for illnesses and injuries that affect vocal function in college health settings. STUDY DESIGN: This pilot study utilized a web-based cross-sectional survey design incorporating common clinical scenarios to test knowledge of evaluation and management strategies in the vocal performing artist. METHODS: A web-based survey was administered to a purposive sample of 28 clinicians to identify the approach utilized to evaluate and treat vocal performing artists in college health settings, and factors that might affect knowledge gaps and influence referral patterns to voice specialists...
July 28, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28754578/reliability-and-validation-of-the-turkish-version-of-the-pediatric-voice-related-quality-of-life-survey
#20
Ziya Salturk, Erdi Ozdemir, Tolgar Lutfi Kumral, İbrahim Sayin, Kürşat Yelken, Hüseyin Sari, Güler Berkiten, Yavuz Atar, Belgin Tutar, Ahmet Arslanoglu, Yavuz Uyar
OBJECTIVE: To evaluate the effect of dysphonia in children, several methods have been developed, including the Pediatric Voice Outcome Survey, the Pediatric Voice Handicap Index, and the Pediatric Voice-Related Quality of Life (PVRQOL) Survey. The aim of this study was to analyze the validity of the Turkish version of the PVRQOL Survey. METHODS: The PVRQOL Survey consists of 10 questions that evaluate the effects of dysphonia on quality of life. We translated it into Turkish by working with two translators and faculty from the English Grammar and Literature Department...
July 25, 2017: Journal of Voice: Official Journal of the Voice Foundation
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