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REVIEW
Guanyu Shi, Leibo Wang, Guangxu Peng, Xu An, Xingyong Lu, Huagu Wu, Yongjun Li
RATIONALE: Eosinophilic cystitis (EC) is a rare and specific transmural inflammatory disease in clinic. At present, its etiology is unknown, its clinical manifestations are diverse, and its auxiliary examination lacks specificity, so it is easy to be missed or misdiagnosed in clinical practice. PATIENT CONCERNS: A 72-year-old male patient with symptoms of lower urinary tract obstruction accompanied by hematuria was diagnosed with benign prostatic hyperplasia with bleeding by B-ultrasound and urinary CT examination...
February 16, 2024: Medicine (Baltimore)
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JOURNAL ARTICLE
Anika Wahl, Martin A Fischer, Kathleen Klaper, Annelie Müller, Stefan Borgmann, Johannes Friesen, Klaus-Peter Hunfeld, Arkadius Ilmberger, Susanne Kolbe-Busch, Michael Kresken, Norman Lippmann, Christoph Lübbert, Matthias Marschner, Bernd Neumann, Niels Pfennigwerth, Michael Probst-Kepper, Jürgen Rödel, Marco H Schulze, Andreas E Zautner, Guido Werner, Yvonne Pfeifer
BACKGROUND: Klebsiella (K.) pneumoniae is a ubiquitous Gram-negative bacterium and a common coloniser of animals and humans. Today, K. pneumoniae is one of the most persistent nosocomial pathogens worldwide and poses a severe threat/burden to public health by causing urinary tract infections, pneumonia and bloodstream infections. Infections mainly affect immunocompromised individuals and hospitalised patients. In recent years, a new type of K. pneumoniae has emerged associated with community-acquired infections such as pyogenic liver abscess in otherwise healthy individuals and is therefore termed hypervirulent K...
March 2024: International Journal of Medical Microbiology: IJMM
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JOURNAL ARTICLE
Maria Jebbia, Sudipti Gupta, Brett G Klamer, Leeann Pavlek, Christina B Ching, Tahagod H Mohamed, Brian Becknell
Urinary tract infections (UTIs) are a common comorbidity in hospitalized neonates. The current UTI diagnostics have several limitations including invasive collection of urinary samples to ensure sterility, risk of contamination and lack of consensus definitions of UTI based on urine culture. Antimicrobial peptides (AMPs) have been recently utilized as novel biomarkers that can efficiently and accurately diagnose pediatric UTI. However, the concentration of AMPs in neonatal urine is not well-defined. Urine from neonates admitted to a single level IV neonatal intensive care unit was obtained to determine baseline concentration of two AMPs, Ribonuclease 7 (RNase 7) and Beta Defensin-1 (BD-1) and to define the relationship between AMP concentration and gestational age (GA)...
February 6, 2024: Scientific Reports
#24
JOURNAL ARTICLE
Reduced graft survival in renal transplant patients with urinary tract infections - a meta-analysis.
Aimi Dm Hamilton, Helle A Prætorius
INTRODUCTION: Renal transplant patients are prone to developing urinary tract infections (UTIs). However, the potential effect of a UTI on renal graft loss remains unclear. METHODS: We systematically surveyed the literature for a potential association between UTI and graft loss. Articles were identified in online databases using a specific search string, followed by post selection for meta-analysis following four inclusion criteria: 1) a clear definition of UTI and recurrent UTI, 2) n > 200, 3) patient age > 16 years and 4) inclusion of data on graft loss...
January 15, 2024: Danish Medical Journal
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JOURNAL ARTICLE
Nathan M Money, Yu Hsiang J Lo, Hannah King, Christopher Graves, Jamie Lynn Holland, Alexander Rogers, Andrew N Hashikawa, Andrea T Cruz, Douglas J Lorenz, Sriram Ramgopal
BACKGROUND: There is insufficient evidence to guide the initial evaluation of hypothermic infants. We aimed to evaluate risk factors for serious bacterial infections (SBI) among hypothermic infants presenting to the emergency department (ED). METHODS: We conducted a multicenter case-control study among hypothermic (rectal temperature <36.5°C) infants ≤90 days presenting to the ED who had a blood culture collected. Our outcome was SBI (bacteremia, bacterial meningitis, and/or urinary tract infection)...
February 5, 2024: Hospital Pediatrics
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JOURNAL ARTICLE
Gabriel Kambale Bunduki, Effita Masoamphambe, Tilly Fox, Janelisa Musaya, Patrick Musicha, Nicholas Feasey
BACKGROUND: Healthcare-associated infections (HCAI) place a significant burden on healthcare systems globally. This systematic review and meta-analysis aimed to investigate the prevalence, risk factors, and aetiologic agents of endemic HCAI in Africa. METHODS: MEDLINE/PubMed, CINAHL, and Global Health databases (EBSCOhost interface) were searched for studies published in English and French describing HCAI in Africa from 2010 to 2022. We extracted data on prevalence of HCAI, risk factors, aetiologic agents, and associated antimicrobial resistance patterns...
February 2, 2024: BMC Infectious Diseases
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JOURNAL ARTICLE
Marzieh Akhlaghpour, Emery Haley, Laura Parnell, Natalie Luke, Mohit Mathur, Richard A Festa, Michael Percaccio, Jesus Magallon, Mariana Remedios-Chan, Alain Rosas, Jimin Wang, Yan Jiang, Lori Anderson, David Baunoch
BACKGROUND: Current diagnoses of urinary tract infection (UTI) by standard urine culture (SUC) has significant limitations in sensitivity, especially for fastidious organisms, and the ability to identify organisms in polymicrobial infections. The significant rate of both SUC "negative" or "mixed flora/contamination" results in UTI cases and the high prevalence of asymptomatic bacteriuria indicate the need for an accurate diagnostic test to help identify true UTI cases. This study aimed to determine if infection-associated urinary biomarkers can differentiate definitive UTI cases from non-UTI controls...
January 31, 2024: BMC Infectious Diseases
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JOURNAL ARTICLE
Ryutaro Saura, Shin-Ichiro Hagiwara, Keinosuke Hizuka, Nobuhiko Okamoto, Yuri Etani
We report the case of twins diagnosed with chronic enteropathy associated with the SLCO2A1 gene (CEAS) based on characteristic ulcer findings, which required 8 years to diagnose. Both twins had similar symptoms, including anemia and growth failure but the gastrointestinal tract was not evaluated initially because of mild symptoms that were considered consistent with psychological etiology. The endoscopic findings of the firstborn child showed spiral ulcer scars and pseudodiverticulum formation without Helicobacter pylori infection or eosinophilic infiltration in the duodenum...
January 30, 2024: Clinical Journal of Gastroenterology
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JOURNAL ARTICLE
Daniel Selig, Diana Caridha, Martin Evans, Adrian Kress, Charlotte Lanteri, Roseanne Ressner, Jesse DeLuca
We sought to better understand the utility and role of animal models of infection for Food and Drug Administration (FDA)-approved antibiotics for the indications of community-, hospital-acquired-, and ventilator-associated bacterial pneumonia (CABP, HABP, VABP), complicated urinary tract infection (cUTI), complicated intra-abdominal infection (cIAI), and acute bacterial skin and structural infections (ABSSSIs). We reviewed relevant documents from new drug applications (NDA) of FDA-approved antibiotics from 2014-2019 for the above indications...
January 19, 2024: Journal of Personalized Medicine
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JOURNAL ARTICLE
Milo Gatti, Cecilia Bonazzetti, Renato Pascale, Maddalena Giannella, Pierluigi Viale, Federico Pea
(1) Objectives: To assess the impact of optimal joint pharmacokinetic/pharmacodynamic (PK/PD) target attainment of continuous infusion (CI) piperacillin-tazobactam monotherapy on the microbiological outcome of documented ESBL-producing Enterobacterlaes secondary bloodstream infections (BSIs). (2) Methods: Patients hospitalized in the period January 2022-October 2023, having a documented secondary BSI caused by ESBL-producing Enterobacterales , and being eligible for definitive targeted CI piperacillin-tazobactam monotherapy according to specific pre-defined inclusion criteria (i...
January 12, 2024: Microorganisms
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JOURNAL ARTICLE
Enrique Rodríguez-Guerrero, José Moya-López, Manuela Expósito-Ruiz, José María Navarro-Marí, José Gutiérrez-Fernández
PURPOSE: We evaluated a modification of automated antibiograms in urine cultures designed to facilitate the early interpretation of minimum inhibitory concentrations (MICs) and accelerate the targeted treatment of urinary tract infections (UTIs), METHODS: A prospective study was conducted of 309 isolates (219 Enterobacteriaceae, 75 Enterococcus spp., and 15 non-fermenting Gram-negative bacilli (NFGNB), and a retrospective study of 9 carbapenemase-producing clinical isolates from urine cultures...
January 12, 2024: European Journal of Clinical Microbiology & Infectious Diseases
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JOURNAL ARTICLE
Neeta Gade, Ranga Burri, Akkilagunta Sujiv, Meena Mishra, B E Pradeep, Harish Debaje, Tejswini Sable, Amandeep Kaur
INTRODUCTION: Device-associated healthcare infections are among the prevailing threats to patient safety worldwide. They constitute the third most common adverse event during healthcare delivery, resulting in heightened morbidity, mortality, and healthcare costs. Patients in intensive care units (ICUs) are at increased risk for device-associated healthcare infections. Focused active surveillance is a crucial measure for assessing the prevalence of healthcare-associated infections and controlling the transmission of pathogens, ultimately contributing to the establishment of quality outcome indicators...
December 2023: Curēus
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JOURNAL ARTICLE
Victor D Rosenthal, Ruijie Yin, Patricio Nercelles, Sara E Rivera-Molina, Somani Jyoti, Reshma Dongol, Daisy Aguilar-De-Moros, Nellie Tumu, Johana Alarcon-Rua, Juan P Stagnaro, Safaa Alkhawaja, Luisa F Jimenez-Alvarez, Yuliana A Cano-Medina, Sandra L Valderrama-Beltran, Claudia M Henao-Rodas, Maria A Zuniga-Chavarria, Amani El-Kholy, Hala Mounir Agha, Suneeta Sahu, Siksha O Anusandhan, Mahuya Bhattacharyya, Mohit Kharbanda, Aruna Poojary, Pravin K Nair, Sheila N Myatra, Rajesh Chawla, Kavita Sandhu, Yatin Mehta, Prasad Rajhans, Farid Zand, Mohammad Abdellatif-Daboor, Chian-Wern Tai, Chin S Gan, Mohd-Basri Mat Nor, Guadalupe Aguirre-Avalos, Blanca E Hernandez-Chena, Alejandro Sassoe-Gonzalez, Isabel Villegas-Mota, Mary C Aleman-Bocanegra, Ider Bat-Erdene, Nilton Y Carreazo, Alex Castaneda-Sabogal, Jarosław Janc, Vladislav Belskiy, Sona Hlinkova, Dincer Yildizdas, Merve Havan, Alper Koker, Hulya Sungurtekin, Ener C Dinleyici, Ertugrul Guclu, Lili Tao, Ziad A Memish, Zhilin Jin
BACKGROUND: Reporting on the International Nosocomial Infection Control Consortium study results from 2015 to 2020, conducted in 630 intensive care units across 123 cities in 45 countries spanning Africa, Asia, Eastern Europe, Latin America, and the Middle East. METHODS: Prospective intensive care unit patient data collected via International Nosocomial Infection Control Consortium Surveillance Online System. Centers for Disease Control and Prevention/National Health Care Safety Network definitions applied for device-associated health care-associated infections (DA-HAI)...
January 6, 2024: American Journal of Infection Control
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JOURNAL ARTICLE
Jesse A Codner, Eli Mlaver, Gina Solomon, Muhammad Saeed, Mengyu Di, Virginia O Shaffer, Christopher J Dente, John F Sweeney, Rachel E Patzer, Jyotirmay Sharma
Background: The Georgia Quality Improvement Program (GQIP) surgical collaborative participating hospitals have shown consistently poor performance in the post-operative sepsis category of National Surgical Quality Improvement Program data as compared with national benchmarks. We aimed to compare crude versus risk-adjusted post-operative sepsis rankings to determine high and low performers amongst GQIP hospitals. Patients and Methods: The cohort included intra-abdominal general surgery patients across 10 collaborative hospitals from 2015 to 2020...
December 29, 2023: Surgical Infections
#35
JOURNAL ARTICLE
Emery Haley, Natalie Luke, Mohit Mathur, Richard A Festa, Jimin Wang, Yan Jiang, Lori Anderson, David Baunoch
BACKGROUND: Multiplex polymerase chain reaction (M-PCR) has increased sensitivity for microbial detection compared with standard urine culture (SUC) in cases diagnosed as urinary tract infections (UTIs), leading to questions whether detected microbes are likely causative of UTIs or are incidental findings. OBJECTIVE: To compare infection-associated biomarker levels against M-PCR and SUC results in symptomatic cases with a presumptive diagnosis of a UTI by a urologist...
December 2023: European urology open science
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JOURNAL ARTICLE
Awareness, Knowledge, and Attitude Towards Urinary Tract Infections: An Appraisal From Saudi Arabia.
Abdullatif K Almaghlouth, Reda A Alkhalaf, Abdulaziz A Alshamrani, Jumanah A Alibrahim, Baker S Alhulibi, Ali Y Al-Yousef, Aisha K Alamer, Saud M Alsuabie, Sukainah M Almuhanna, Abdullah D Alshehri
Introduction Urinary tract infections (UTIs) are a common global health issue, yet awareness and knowledge about UTIs among the general population can vary widely. This study aimed to assess the awareness, knowledge, and attitudes regarding UTIs among Saudi Arabian citizens residing in Al-Ahsa, Saudi Arabia. Methods A descriptive cross-sectional study was conducted among Saudi Arabian citizens aged 18 and above residing in Alhassa. A structured questionnaire was used to collect data on participants' awareness, knowledge, attitudes, and experiences related to UTIs...
November 2023: Curēus
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JOURNAL ARTICLE
Helen L Zhang, Reinaldo Perez, Jay Krishnan, Ebbing Lautenbach, Deverick J Anderson
BACKGROUND: Extended-spectrum cephalosporin-resistant Enterobacterales (ESCrE) are an increasingly important cause of community-onset urinary tract infections (UTIs), including recurrent infections. We evaluated risk factors for recurrence among patients with community-onset ESCrE UTI. METHODS: This retrospective cohort study included adults with community-onset ESCrE UTI in the Duke University Health System from April 2018 through December 2021. ESCrE UTI recurrence by the same species was assessed 14-180 days (ie, 6 months) after completion of antibiotic treatment...
December 2023: Open Forum Infectious Diseases
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JOURNAL ARTICLE
Ruchita Lohiya, Vijayshri Deotale
INTRODUCTION: Because the risk of health-care associated infections (HAIs) is high in intensive care units, and HAIs are one of the causes of morbidity and mortality and affects the overall quality of health care, the continuous monitoring of HAIs in intensive care patients is essential. AIM AND OBJECTIVES: This descriptive cross-sectional study was carried out over a period of five years in a tertiary-care teaching hospital. The aim of the study was to investigate the main and specific types of health-care associated Infections and determine the microbiological profile and antimicrobial susceptibility rates of isolates in patients with HAI...
2023: GMS Hygiene and Infection Control
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JOURNAL ARTICLE
Natália Vasconcellos de Oliveira Souza, Carolina Rouanet, Davi Jorge Fontoura Solla, Caio Vinícius Barroso de Lima, Juliana Trevizo, Flavio Rezende, Maramelia Miranda Alves, Airton Leonardo de Oliveira Manuel, Cassia Righy, Feres Chaddad Neto, Michel Frudit, Gisele Sampaio Silva
OBJECTIVE: Almost two thirds of the world's aneurysmal subarachnoid hemorrhage (aSAH) are in low- and middle-income countries. Herein, we aimed to evaluate the impact of complications on the outcome of aSAH in a middle-income country. METHODS: Baseline data (age, sex, World Federation of Neurosurgical Society, time ictus-treatment, treatment modality) and medical and neurologic complications from a cohort in Brazil (2016-2019) were evaluated: delayed cerebral ischemia; hydrocephalus; meningitis; seizures; intracranial hypertension; infections (pneumonia, bloodstream, urinary tract infection infection of undetermined source); sodium disturbances; acute kidney injury; and cardiac and pulmonary complications...
December 15, 2023: World Neurosurgery
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JOURNAL ARTICLE
Krishna Prasad Shanbhogue, Nisha Ramani, Venkateswar R Surabhi, Rashmi Balasubramanya, Srinivasa R Prasad
A diverse spectrum of pathologically distinct, nonneoplastic, proliferative conditions of the kidneys and urinary tract demonstrate a expansile growth pattern similar to that of neoplasms. The renal pseudotumors include myriad causes of infections as well as rare noninfectious causes such as sarcoidosis, amyloidosis, and immunoglobulin G4-related disease (IgG4-RD). Rare entities such as cystitis cystica, endometriosis, nephrogenic adenoma, and pseudosarcomatous myofibroblastic proliferation and distinct types of prostatitis comprise tumefactive nontumorous disorders that affect specific segments of the urinary tract...
December 2023: Radiographics: a Review Publication of the Radiological Society of North America, Inc
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