Maria Carolina Borges, Gemma L Clayton, Rachel M Freathy, Janine F Felix, Alba Fernández-Sanlés, Ana Gonçalves Soares, Fanny Kilpi, Qian Yang, Rosemary R C McEachan, Rebecca C Richmond, Xueping Liu, Line Skotte, Amaia Irizar, Andrew T Hattersley, Barbara Bodinier, Denise M Scholtens, Ellen A Nohr, Tom A Bond, M Geoffrey Hayes, Jane West, Jessica Tyrrell, John Wright, Luigi Bouchard, Mario Murcia, Mariona Bustamante, Marc Chadeau-Hyam, Marjo-Riitta Jarvelin, Martine Vrijheid, Patrice Perron, Per Magnus, Romy Gaillard, Vincent W V Jaddoe, William L Lowe, Bjarke Feenstra, Marie-France Hivert, Thorkild I A Sørensen, Siri E Håberg, Sylvain Serbert, Maria Magnus, Deborah A Lawlor
BACKGROUND: Higher maternal pre-pregnancy body mass index (BMI) is associated with adverse pregnancy and perinatal outcomes. However, whether these associations are causal remains unclear. METHODS: We explored the relation of maternal pre-/early-pregnancy BMI with 20 pregnancy and perinatal outcomes by integrating evidence from three different approaches (i.e. multivariable regression, Mendelian randomisation, and paternal negative control analyses), including data from over 400,000 women...
January 29, 2024: BMC Medicine