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https://www.readbyqxmd.com/read/28540853/determination-of-serum-albumin-analytical-challenges-a-french-multicenter-study
#1
Adrien Rossary, Françoise Blondé-Cynober, Jean-Philippe Bastard, Marie-Christine Beauvieux, Pascale Beyne, Jocelyne Drai, Christine Lombard, Ingrid Anglard, Christian Aussel, Sophie Claeyssens, Marie-Paule Vasson
Among the biological markers of morbidity and mortality, albumin holds a key place in the range of criteria used by the High Authority for Health (HAS) for the assessment of malnutrition and the coding of information system medicalization program (PMSI). If the principle of quantification methods have not changed in recent years, the dispersion of external evaluations of the quality (EEQ) data shows that the standardization using the certified reference material (CRM) 470 is not optimal. The aim of this multicenter study involving 7 sites, conducted by a working group of the French Society of Clinical Biology (SFBC), was to assess whether the albuminemia values depend on the analytical system used...
June 1, 2017: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/28538834/characteristics-of-liver-fibrosis-with-different-etiologies-using-a-fully-quantitative-fibrosis-assessment-tool
#2
Q Wu, X Zhao, H You
This study aimed to test the diagnostic performance of a fully quantitative fibrosis assessment tool for liver fibrosis in patients with chronic hepatitis B (CHB), primary biliary cirrhosis (PBC) and non-alcoholic steatohepatitis (NASH). A total of 117 patients with liver fibrosis were included in this study, including 50 patients with CHB, 49 patients with PBC and 18 patients with NASH. All patients underwent liver biopsy (LB). Fibrosis stages were assessed by two experienced pathologists. Histopathological images of LB slices were processed by second harmonic generation (SHG)/two-photon excited fluorescence (TPEF) microscopy without staining, a system called qFibrosis (quantitative fibrosis) system...
May 18, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28536056/predicting-healthy-eating-intention-and-adherence-to-dietary-recommendations-during-pregnancy-in-australia-using-the-theory-of-planned-behaviour
#3
Lenka Malek, Wendy J Umberger, Maria Makrides, ShaoJia Zhou
This study aims to aid in the development of more effective healthy eating intervention strategies for pregnant women by understanding the relationship between healthy eating intention and actual eating behaviour. Specifically, the study explored whether Theory of Planned Behaviour (TPB) constructs [attitude, subjective-norm, perceived-behavioural-control (PBC)] and additional psychosocial variables (perceived stress, health value and self-identity as a healthy eater) are useful in explaining variance in women's 1) intentions to consume a healthy diet during pregnancy and 2) food consumption behaviour (e...
May 20, 2017: Appetite
https://www.readbyqxmd.com/read/28535947/geoepidemiology-clinical-manifestations-and-outcome-of-primary-biliary-cholangitis-in-greece
#4
Nikolaos K Gatselis, Kalliopi Zachou, Vasiliki Lygoura, Kalliopi Azariadis, Pinelopi Arvaniti, Elias Spyrou, Georgia Papadamou, George K Koukoulis, George N Dalekos, Eirini I Rigopoulou
BACKGROUND & AIMS: Primary biliary cholangitis (PBC) is a disease with rising prevalence and considerable geographical variation. To describe the prevalence, spatial and time distribution, baseline characteristics, response to treatment, outcome and the validity of GLOBE score in a large cohort of Greek PBC patients as an independent validation of this score has not been done so far. METHODS: The last 16years, 482 PBC patients (86.5% females) were evaluated and analysed retrospectively, using a prospectively collected database...
May 20, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28535921/out-of-field-in-vivo-dosimetry-using-tld-in-sabr-for-primary-kidney-cancer-involving-mixed-photon-fields
#5
P Lonski, S Keehan, S Siva, D Pham, R D Franich, M L Taylor, T Kron
PURPOSE: To assess out-of-field dose using three different variants of LiF thermoluminescence dosimeters (TLD) for ten patients who underwent stereotactic ablative body radiotherapy (SABR) for primary renal cell carcinoma (RCC) and compare with treatment planning system (TPS) dose calculations. METHODS AND MATERIALS: Thermoluminescent dosimeter (TLD) measurements were conducted at 20, 30, 40 and 50cm from isocentre on ten patients undergoing SABR for primary RCC...
May 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28529880/cytologic-assessment-of-estrogen-receptor-progesterone-receptor-and-her2-status-in-metastatic-breast-carcinoma
#6
Fresia Pareja, Melissa P Murray, Ryan Des Jean, Fumiko Konno, Maria Friedlander, Oscar Lin, Marcia Edelweiss
BACKGROUND: Discordance in the receptor status between primary breast carcinomas (PBC) and corresponding metastasis is well documented. Interrogation of the receptor status of metastatic breast carcinoma (MBC) in cytology material is common practice; however, its utility has not been thoroughly validated. We studied patients with MBC, and evaluated the concordance rates of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) between PBC surgical specimens and corresponding MBC cell blocks (CBs)...
January 2017: Journal of the American Society of Cytopathology
https://www.readbyqxmd.com/read/28522403/multiplex-autoantibody-detection-for-autoimmune-liver-diseases-and-autoimmune-gastritis
#7
Joris Vanderlocht, Mart van der Cruys, Frans Stals, Liesbeth Bakker-Jonges, Jan Damoiseaux
Autoantibody detection for autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and autoimmune gastritis (AIG) is traditionally performed by IIF on a combination of tissues. Multiplex line/dot blots (LIA/DIA) offer multiple advantages, i.e. automation, objective reading, no interfering reactivities, no coincidental findings. In the current study we evaluated automated DIA (D-Tek) for detecting autoantibodies related to autoimmune diseases of the gastrointestinal tract. We tested samples of the Dutch EQC program and compared the results with the consensus of the participating labs...
May 15, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/28517369/treatment-of-primary-biliary-cholangitis-non-responders-a-systematic-review
#8
Duminda Suraweera, Harman Rahal, Melissa Jimenez, Matthew Viramontes, Gina Choi, Sammy Saab
BACKGROUND: Primary biliary cholangitis (PBC), formerly known as primary biliary cirrhosis, is a chronic cholestatic liver disease characterized by an immune mediated destruction of intrahepatic bile ducts. Ursodeoxycholic acid (UDCA) has been the primary medication for the treatment of PBC, resulting in improved liver tests, resolution of symptoms and increased transplant free survival. However, not all patients respond to UDCA. The aim of this systematic review is to provide an evidence based assessment of the medications that have been studied in patients who are refractory to UDCA...
May 18, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28494557/-clinicopathologic-features-of-drug-induced-vanishing-bile-duct-syndrome
#9
L H Ye, C K Wang, H C Zhang, Z Q Liu, H W Zheng
Vanishing bile duct syndrome (VBDS) manifests as progressive destruction and disappearance of the intrahepatic bile duct caused by various factors and cholestasis. VBDS associated with drug-induced liver injury (D-VBDS) is an important etiology of VBDS, and immune disorder or immune imbalance may be the main pathogenesis. According to its clinical symptoms, serological markers, and course of the disease, D-VBDS is classified into major form and minor form, and its clinical features are based on various pathomorphological findings...
April 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/28487448/incidence-of-primary-biliary-cholangitis-in-a-rural-midwestern-population
#10
Rajan Kanth, Ram Babu Shrestha, Indira Rai, Jeffrey J VanWormer, Praveen K Roy
BACKGROUND: Primary biliary cholangitis (PBC) is a rare disease with incidence that varies with time and geography. Only two studies have assessed PBC incidence of in the United States, with the most recent appearing over a decade ago. The objective of the present study was to assess PBC incidence in the United States in a more recent era. METHODS: The incidence of PBC was assessed in a population-based cohort in rural, Midwestern Wisconsin over two decades spanning from June 1992 through June 2011...
May 9, 2017: Clinical Medicine & Research
https://www.readbyqxmd.com/read/28475967/a-comparative-study-on-the-experimental-and-calculated-results-of-mid-infrared-and-raman-vibrational-modes-of-nucleic-acid-bases
#11
Fang Wang, Dongbo Zhao, Ling Jiang, Li Xu, Haijun Sun, Yunfei Liu
The MIR (mid-infrared) and Raman spectra of the nucleic acid base powders were tested by Fourier transform infrared spectroscopy and laser Raman spectroscopy. The vibrational modes of nucleic acid base crystals were simulated by the generalized energy-based fragmentation approach under periodic boundary conditions (hereinafter referred as PBC-GEBF) together with Guassian09 software. Taking into account the intermolecular hydrogen bonds in the unit cell and the weak interactions between the unit cells, the PBC-GEBF method adopted by our group was for the first time used for calculating nucleic acid base crystals in the 400-2000cm(-1) band...
April 22, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28470667/autoreactive-monoclonal-antibodies-from-patients-with-primary-biliary-cholangitis-recognize-environmental-xenobiotics
#12
Toshihiro Tanaka, Weici Zhang, Ying Sun, Zongwen Shuai, Asiya Chida, Thomas P Kenny, Guo-Xiang Yang, Ignacio Sanz, Aftab Ansai, Christopher L Bowlus, Gregory C Ippolito, Ross L Coppel, Kazuichi Okazaki, Xiao-Song He, Patrick S C Leung, M Eric Gershwin
A major problem in autoimmunity has been identification of the earliest events that lead to breach of tolerance. Although there have been major advances in dissecting effector pathways and the multi-lineage immune responses to mitochondrial self-antigens in primary biliary cholangitis (PBC), the critical links between environmental factors and tolerance remain elusive. We hypothesized that environmental xenobiotic modification of the E2 subunit of the pyruvate dehydrogenase (PDC-E2) inner lipoyl domain can lead to loss of tolerance to genetically susceptible hosts...
May 3, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28468009/what-comes-after-ursodeoxycholic-acid-in-primary-biliary-cholangitis
#13
Lin Lee Wong, Vinod S Hegade, David E J Jones
Primary biliary cholangitis (PBC) is a rare autoimmune liver disease characterized by chronic cholestasis. Treatment with the accepted primary therapy ursodeoxycholic acid (UDCA) has been shown to be associated with delayed disease progression probably through reduced impact of cholestatic injury on the target biliary epithelial cells. Patients with inadequate response to UDCA (which can be identified through validated biochemical criteria) are at increased risk of disease progression, need for liver transplantation, and death...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/28465155/effect-of-liver-disease-on-hepatic-transporter-expression-and-function
#14
REVIEW
Nilay Thakkar, Jason R Slizgi, Kim L R Brouwer
Liver disease can alter the disposition of xenobiotics and endogenous substances. Regulatory agencies such as the Food and Drug Administration (FDA) and the European Medicines Evaluation Agency (EMEA) recommend, if possible, studying the effect of liver disease on drugs under development to guide specific dose recommendations in these patients. While extensive research has been conducted to characterize the effect of liver disease on drug-metabolizing enzymes, emerging data have implicated that the expression and/or function of hepatobiliary transport proteins also are altered in liver disease...
April 29, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28458649/what-influences-chinese-adolescents-choice-intention-between-playing-online-games-and-learning-application-of-theory-of-planned-behavior-with-subjective-norm-manipulated-as-peer-support-and-parental-monitoring
#15
Jia Wang, Ru-De Liu, Yi Ding, Ying Liu, Le Xu, Rui Zhen
This study investigated how and why Chinese adolescents choose between playing online games and doing homework, using the model of the theory of planned behavior (TPB) in which the subjective norm was manipulated as two sub-elements (peer support and parental monitoring). A total of 530 students from an elementary school and a middle school in China were asked to complete the measures assessing two predictors of TPB: attitude and perceived behavioral control (PBC). Next, they completed a survey about their choice intention between playing an online game and doing homework in three different situations, wherein a conflict between playing online games and doing homework was introduced and subjective norm was manipulated as peers supporting and parents objecting to playing online games...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28450949/genetic-variation-in-the-3-untranslated-region-of-pak1-influences-schizophrenia-susceptibility
#16
Juan Jiang, Jianxiong Long, Weijun Ling, Guifeng Huang, Li Su
The present study aimed to investigate the association of two polymorphisms (rs2844337 and rs11237200) in the P21 protein (cell division control protein 42/Rac)-activated kinase 1 gene with susceptibility to schizophrenia (SCZ) in Chinese Zhuang and Chinese Han populations. A total of 700 patients with SCZ and 700 healthy controls were recruited. Rs2844337 and rs11237200 polymorphisms were genotyped using Sequenom technology. A total of 591 patients completed the Positive and Negative Syndrome Scale (PANSS) assessment...
March 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28447402/is-extra-glandular-organ-damage-in-primary-sj%C3%A3-gren-s-syndrome-related-to-the-presence-of-systemic-auto-antibodies-and-or-hypergammaglobulinemia-a-long-term-cohort-study-with-110-patients-from-the-netherlands
#17
Evert-Jan Ter Borg, Johannes Cornelis Kelder
AIM: To test the hypothesis that systemic auto-antibodies or hypergammaglobulinemia are related to the prevalence of extra-glandular tissue organ damage (EGOD) in primary Sjögren's syndrome (SS). METHODS: A real practice-based investigation of a relatively large (n = 110) Dutch cohort of primary SS patients systematically followed up in a large non-academic hospital. RESULTS: After a follow up of mean 8.2 years a significant correlation was found between disease duration and the prevalence of EGOD...
April 26, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28441778/gene-expression-analysis-before-and-after-treatment-with-adalimumab-in-patients-with-ankylosing-spondylitis-identifies-molecular-pathways-associated-with-response-to-therapy
#18
Marzia Dolcino, Elisa Tinazzi, Andrea Pelosi, Giuseppe Patuzzo, Francesca Moretta, Claudio Lunardi, Antonio Puccetti
The etiology of Ankylosing spondylitis (AS) is still unknown and the identification of the involved molecular pathogenetic pathways is a current challenge in the study of the disease. Adalimumab (ADA), an anti-tumor necrosis factor (TNF)-alpha agent, is used in the treatment of AS. We aimed at identifying pathogenetic pathways modified by ADA in patients with a good response to the treatment. Gene expression analysis of Peripheral Blood Cells (PBC) from six responders and four not responder patients was performed before and after treatment...
April 24, 2017: Genes
https://www.readbyqxmd.com/read/28435945/enhanced-durability-and-activity-of-the-perovskite-electrocatalyst-pr0-5ba0-5coo3-%C3%AE-by-ca-doping-for-the-oxygen-evolution-reaction-at-room-temperature
#19
Dandan He, Guanghu He, Heqing Jiang, Zongkun Chen, Minghua Huang
A promising Ca doping approach was reported to improve the durability and electrocatalytic OER activity of the perovskite Pr0.5Ba0.5CoO3-δ (PBC). Compared to the pristine PBC, the electrocatalytic activity of Ca-doped Pr0.5Ba0.3Ca0.2CoO3-δ perovskite was increased by ca. 90%. More importantly, its durability was significantly enhanced after doping with calcium.
May 4, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28427765/easl-clinical-practice-guidelines-the-diagnosis-and-management-of-patients-with-primary-biliary-cholangitis
#20
(no author information available yet)
Primary biliary cholangitis (PBC) is a chronic inflammatory autoimmune cholestatic liver disease, which when untreated will culminate in end-stage biliary cirrhosis. Diagnosis is usually based on the presence of serum liver tests indicative of a cholestatic hepatitis in association with circulating antimitochondrial antibodies. Patient presentation and course can be diverse and risk stratification is important to ensure all patients receive a personalised approach to their care. The goals of treatment and management are the prevention of end-stage liver disease, and the amelioration of associated symptoms...
April 18, 2017: Journal of Hepatology
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