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Gopal Shankar Krishnakumar, Natalia Gostynska, Elisabetta Campodoni, Massimiliano Dapporto, Monica Montesi, Silvia Panseri, Anna Tampieri, Elizaveta Kon, Maurilio Marcacci, Simone Sprio, Monica Sandri
This study explores for the first time the application of ribose as a highly biocompatible agent for the crosslinking of hybrid mineralized constructs, obtained by bio-inspired mineralization of self-assembling Type I collagen matrix with magnesium-doped-hydroxyapatite nanophase, towards a biomimetic mineralized 3D scaffolds (MgHA/Coll) with excellent compositional and structural mimicry of bone tissue. To this aim, two different crosslinking mechanisms in terms of pre-ribose glycation (before freeze drying) and post-ribose glycation (after freeze drying) were investigated...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
Farnaz Ghorbani, Ali Zamanian, Hanieh Nojehdehian
Different manufacturing processes of scaffolds affect their main properties by altering the microstructure of pores. In this study, poly (lactic-co-glycolic acid) (PLGA) scaffolds were synthesized by both freeze casting and freeze drying methods. Scanning electron microscopy (SEM) micrographs demonstrated a unidirectional microstructure in the freeze-cast and a number of random pores in the freeze-dried scaffolds. According to the results, the formation of a lamellar microstructure increased the mechanical strength, swelling ratio, biodegradation behavior and drug release level...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
Mohammad Karimi, Majid Rastegar Ramsheh, Seyed Mohammad Ahmadi, Mohammad Reza Madani, Mehdi Shamsi, Reyhaneh Reshadi, Farahnaz Lotfi
A fast, simple and sustainable method based on choline chloride-urea deep eutectic solvent (known as Reline) was employed to synthesize nanosized fluorapatite (FA) particles. Using XRD, FESEM, TEM, EDS, and FTIR, the formation of FA nanoparticles with average crystal size of ~34nm, percent crystallinity of 93%, particle size of ~45nm, and high crystal, elemental, and structural purity was confirmed. The MTT cytotoxicity assay endorsed the non-toxicity of as-synthesized FA nanoparticles. The good biocompatibility, osteogenity and mineralization ability of as-synthesized FA nanoparticles were confirmed by Alizarin red staining, Acridine orange staining and ALP activity tests...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
Iva Juranović Cindrić, Michaela Zeiner, Darija Mihajlov-Konanov, Gerhard Stingeder
Black chokeberries (Aronia melanocarpa) are considered to be functional food containing high amounts of anthocyanins, phenols, antioxidants, vitamins and minerals. Whereas organic compounds are well studied, there is little research on the mineral composition of the chokeberries. Thus, the presented study is focused on the determination of Al, As, Ba, Ca, Cd, Co, Cr, Cu, Fe, K, Li, Mg, Mn, Mo, Na, Ni, Pb, Se, Sr and Zn in black chokeberry fruits and infusions to study the metals' extractability. The nutrients Ca, K and Mg are present in the fruits (dried matter) at g/kg level, whereas the other elements are present from µg/kg up to mg/kg level...
May 18, 2017: International Journal of Environmental Research and Public Health
Shilpa Manigatta Doddagowda, Hemalatha Anantharamaiah Shashidhar, Chinaiah Subramanyam Babu Rajendra Prasad
INTRODUCTION: Air dried cytology smears are stained routinely with Romanowsky stains so that the relative cell size, nuclear size, cytoplasmic details, smear background elements and intercellular matrix components are better appreciated. A variety of modified Romanowsky stains are used in cytology. Leishman-Giemsa (LG) cocktail is one of the new staining techniques which can be used for staining the air dried cytology smears. AIM: To evaluate the quality of staining of LG cocktail on air dried smears and to compare the quality of staining of LG cocktail with May Grunwald Giemsa (MGG) which is the most commonly used stain in cytology...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
Adnan Amin, Emmy Tuenter, Kenn Foubert, Jamhsed Iqbal, Paul Cos, Louis Maes, Vassiliki Exarchou, Sandra Apers, Luc Pieters
Background and Aims:Kickxia ramosissima (Wall.) Janch (or Nanorrhinum ramosissimum (Wall.) Betsche is a well-known medicinal plant in Pakistan that is traditionally used in diabetic and inflammatory conditions. Because little information is available on its phytochemical composition, a range of constituents were isolated and evaluated in vitro in assays related to the traditional use. Methods: Dried whole plant material was extracted and chromatographically fractionated. Isolated constituents were evaluated in silico and in vitro in assays related to the traditional use against diabetes (inhibition of α-glucosidase activity; inhibition of advanced glycation endproducts) and in inflammatory conditions (inhibition of AAPH induced linoleic acid peroxidation, inhibition of 15-LOX, antimicrobial activity)...
2017: Frontiers in Pharmacology
Monica Voss, Matheus A G Nunes, Gabriela Corazza, Erico M M Flores, Edson I Müller, Valderi L Dressler
A calibration strategy using porous nylon disks and reference solutions is proposed for the first time for matrix matching and determination of As, Ba, Cd, Cr, Pb, Sr and Zn in polymers by laser ablation-inductively coupled plasma mass spectrometry (LA-ICP-MS). Polymer samples commonly used in contact with food were analyzed. The procedure consists on the use of porous nylon disks as support for a dried droplet reference solution. Calibration in the range of 0.50-190μgg(-1) for Ba, Cd, Cr, Pb, Sr and Zn and from 0...
August 1, 2017: Talanta
Manjari Lal, Manshun Lai, Marcus Estrada, Changcheng Zhu
Current presentations of the anti-HIV drugs lopinavir and ritonavir make appropriate dosing for children difficult. We conducted a feasibility study to develop a formulation for these drugs with child-safe excipients in a flexible dosage form for children across the pediatric age spectrum. The freeze-drying-in-blister approach was used to produce fast-dissolving tablets (FDTs), as these can be dispersed in fluids for easy administration, even to infants, and appropriate portions of the dispersion can be given for different ages/weights...
May 9, 2017: Journal of Pharmaceutical Sciences
Miao Wang, Ilya V Anoshkin, Albert G Nasibulin, Robin H A Ras, Nonappa, Janne Laine, Esko I Kauppinen, Olli Ikkala
Hybrid aerogels consisting of cellulose nanofibers (CNF) and modified few-walled carbon nanotubes (FWCNT) are investigated under cyclic mechanical compression to explore "electrical fatigue". For this purpose the FWCNTs were hydrophilized, thus promoting their aqueous dispersibility to allow FWCNT/CNF hybrid hydrogels, followed by freeze-drying to obtain hybrid aerogels. The optimized composition consisting of FWCNT/CNF 20/80 wt/wt showed conductivity of 10(-5) S cm(-1) as promoted due to double percolation, and showed only small changes in electrical and mechanical behaviour upon cycling 100 times...
September 19, 2016: RSC Advances
Brahmeshwar Mishra, Madhusmita Mishra, Sarita Kumari Yadav
Inhalation delivery of aerosolized antibacterials is preferred over conventional methods of delivery for targeting lung infection. The present study is concerned with the development and characterization of a novel, spray dried, aerosolized, chitosan polyelectrolyte complex (PEC) based microparticles containing antibacterials for the treatment of lung infections. Chitosan polyelectrolyte complex microparticles were formulated by spray drying process. Prepared spray dried chitosan PEC microparticles were studied for surface morphology, drug encapsulation efficiency, moisture content, Carr's index, solid state interaction by XRD, aerosolization behaviour and in-vitro drug release...
2017: Iranian Journal of Pharmaceutical Research: IJPR
Yasuyuki Yoshida, Kazuyuki Takata, Hiroki Takai, Keisuke Kawahara, Akinori Kuzuya, Yuichi Ohya
On clinical application of biodegradable injectable polymer (IP) systems, quick extemporaneous preparation of IP formulations and longer duration time gel state after injection into the body are the important targets to be developed. Previously, we had reported temperature-responsive covalent gelation systems via bio-orthogonal thiol-ene reaction by "mixing strategy" of amphiphilic biodegradable tri-block copolymer (tri-PCG) attaching acryloyl groups on both termini (tri-PCG-Acryl) with reactive polythiol. In other previous works, we found "freeze-dry with PEG/dispersion" method as quick extemporaneous preparation method of biodegradable IP formulations...
May 12, 2017: Journal of Biomaterials Science. Polymer Edition
Kannimuthu Karthick, Sengeni Anantharaj, Pitchiah E Karthik, Balasubramanian Subramanian, Subrata Kundu
Water oxidation in alkaline medium was efficiently catalyzed by the self-assembled molecular hybrids of CoS-DNA that had 20 times lower Co loading than the commonly used loading. The morphological outcome was directed by varying the molar ratio of metal precursor Co(Ac)2 and DNA and three different sets of CoS-DNA molecular hybrids, viz. CoS-DNA(0.036), CoS-DNA(0.06), and CoS-DNA(0.084) were prepared. These morphologically distinct hybrids had shown similar electrocatalytic behavior, because of the fact that they all contained the same cobalt content...
May 11, 2017: Inorganic Chemistry
Ioannis Karapanos, Anastasia Papandreou, Marianna Skouloudi, Despoina Makrogianni, Juan A Fernández, Eduardo Rosa, Georgia Ntatsi, Penelope J Bebeli, Dimitrios Savvas
BACKGROUND: Cowpea is traditionally cultivated in some regions of southern Europe for its dried seeds; however, there is a scarcity of information on the quality and dietary characteristics of fresh pods, which are occasionally used in folk diets. This paper aims at covering this gap in knowledge thereby contributing to the dissemination of fresh cowpea pods as a novel product for the market. The quality and dietary characteristics of pods from 37 accessions (Vigna unguiculata ssp. unguiculata and ssp...
May 8, 2017: Journal of the Science of Food and Agriculture
Sameera R Samarakoon, Chanthirika Shanmuganathan, Meran K Ediriweera, Poorna Piyathilaka, Kamani H Tennekoon, Ira Thabrew, Prasanna Galhena, E Dilip De Silva
CONTEXT: Scyphiphora hydrophyllacea is a shrub mangrove plant of the family Rubiaceae and not yet been studied for anti-hepatocarcinogenic effects. OBJECTIVES: We investigated possible in vitro anti-hepatocarcinogenic and antioxidant properties of S. hydrophyllacea. MATERIALS AND METHODS: Dried leaves of S. hydrophyllacea were sequentially extracted into hexane, chloroform, ethyl acetate, and methanol and tested for cytotoxicity on HepG2 cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and sulforhodamine B assays, and for antioxidant activities by the free radical 1,1-diphenyl-2-picryl-hydrazyl (DPPH) and 2,2'-azino-bis-3-ethylbenzthiazoline-6-sulfonic acid (ABTS) assays...
January 2017: Pharmacognosy Magazine
Tingting Peng, Xuejuan Zhang, Ying Huang, Ziyu Zhao, Qiuying Liao, Jing Xu, Zhengwei Huang, Jiwen Zhang, Chuan-Yu Wu, Xin Pan, Chuanbin Wu
An optimum carrier rugosity is essential to achieve a satisfying drug deposition efficiency for the carrier based dry powder inhalation (DPI). Therefore, a non-organic spray drying technique was firstly used to prepare nanoporous mannitol with small asperities to enhance the DPI aerosolization performance. Ammonium carbonate was used as a pore-forming agent since it decomposed with volatile during preparation. It was found that only the porous structure, and hence the specific surface area and carrier density were changed at different ammonium carbonate concentration...
May 2, 2017: Scientific Reports
Yui Mizowaki, Saeko Sugawara, Kazushi Yamamoto, Yu Sakamoto, Yui Iwagaki, Yuki Kawakami, Miki Igarashi, Tsuyoshi Tsuduki
The Japanese diet and the Mediterranean diet are both known to be good for health, but there had been no direct comparison of their health benefits. In this study, we compared the 1975 Japanese diet, which has been found to have high health benefits, with the 2010 Italian diet, which contributes to the longest life expectancy in Mediterranean countries. Diets were created using one-week menus of the two diets based on FAOSTAT Food Balance Sheets. The diets were prepared, freeze-dried, powdered and fed to mice for 4 weeks to examine their effects on lipid metabolism...
2017: Journal of Oleo Science
Jilai Tian, Caiyun Yan, Kunliang Liu, Juan Tao, Zhenchao Guo, Jianping Liu, Yu Zhang, Fei Xiong, Ning Gu
Magnetic iron oxide nanoparticles (MNPs) are good candidates to implement fluid therapy in critically patients in clinic integrated system. Herein, we synthesized paclitaxel loaded MNPs modified with mPEG-Lys-OA2 (PTX-MNPs-PLO), which is expected to act as a magnetic resonance imaging (MRI) contrast agent and meanwhile for cancer therapy. MNPs were synthesized by thermal decomposition. Dialysis method was applied to prepare PTX-MNPs-PLO with three different PEG molecular weights (1000, 2000, and 4000 Da) which were subsequently freeze-dried into powders...
April 26, 2017: Journal of Pharmaceutical Sciences
Sourav K Mukhopadhyay, Deboki Naskar, Promita Bhattacharjee, Abheepsa Mishra, Subhas C Kundu, Satyahari Dey
Research of improved functional bio-mimetic matrix for regenerative medicine is currently one of the rapidly growing fields in tissue engineering and medical sciences. This study reports a novel bio-polymeric matrix, which is fabricated using silk protein fibroin from Bombyx mori silkworm and fungal exopolysaccharide Thelebolan from Antarctic fungus Thelebolus sp. IITKGP-BT12 by solvent evaporation and freeze drying method. Natural cross linker genipin is used to imprison the Thelebolan within the fibroin network...
April 9, 2017: Colloids and Surfaces. B, Biointerfaces
R Lombard Latune, O Laporte-Daube, N Fina, S Peyrat, L Pelus, P Molle
Plants are essential in the functioning of constructed wetlands. When setting up systems in tropical areas, Phragmites australis is not always a good choice because of its invasiveness. In vertical-flow constructed wetlands (VFCWs) fed with raw wastewater, the main role of plants is their mechanical action, which helps prevent clogging of the deposited organic matter. Various species have already been used in some tropical climate studies, but generally not for such systems, and no attempt has been made to screen large numbers of alternative species...
April 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Chris A Boulton, Ben B B Booth, Peter Good
The future of the Amazon rainforest is unknown due to uncertainties in projected climate change and the response of the forest to this change (forest resiliency). Here we explore the effect of some uncertainties in climate and land surface processes on the future of the forest, using a perturbed physics ensemble of HadCM3C. This is the first time Amazon forest changes are presented using an ensemble exploring both land vegetation processes and physical climate feedbacks in a fully coupled modelling framework...
April 27, 2017: Global Change Biology
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