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https://www.readbyqxmd.com/read/28102694/evaluation-of-sample-extraction-methods-for-minimizing-hematocrit-effect-on-whole-blood-analysis-with-volumetric-absorptive-microsampling
#1
Zhengqi Ye, Hong Gao
AIM: Volumetric absorptive microsampler (VAMS) was designed to sample a fixed volume of blood regardless of the hematocrit (HCT) levels. Model compounds with a wide range of hydrophobicity were evaluated for their extraction recoveries from VAMS dried blood samples. RESULTS: For the highly hydrophobic compounds, recoveries with methanol or methanol/acetonitrile extraction were higher compared with using the aqueous mixture of methanol or acetonitrile. Extraction with methanol/acetonitrile (1:1) yielded more consistent recovery across the HCT range of 20-70% than using methanol alone, with good linearity, accuracy and precision achieved from 1 to 2000 ng/ml...
January 19, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28098752/microbiological-load-of-edible-insects-found-in-belgium
#2
Rudy Caparros Megido, Sandrine Desmedt, Christophe Blecker, François Béra, Éric Haubruge, Taofic Alabi, Frédéric Francis
Edible insects are gaining more and more attention as a sustainable source of animal protein for food and feed in the future. In Belgium, some insect products can be found on the market, and consumers are sourcing fresh insects from fishing stores or towards traditional markets to find exotic insects that are illegal and not sanitarily controlled. From this perspective, this study aims to characterize the microbial load of edible insects found in Belgium (i.e., fresh mealworms and house crickets from European farms and smoked termites and caterpillars from a traditional Congolese market) and to evaluate the efficiency of different processing methods (blanching for all species and freeze-drying and sterilization for European species) in reducing microorganism counts...
January 13, 2017: Insects
https://www.readbyqxmd.com/read/28095185/seasonal-age-and-sex-fluctuations-in-aflatoxin-b1-content-in-the-liver-and-kidney-of-brown-hares-lepus-europaeus-pall
#3
Jaroslav Slamecka, Marcela Capcarova, Rastislav Jurcik, Tomas Sladecek, Maria-Jose Carrascosa Argente, Agnieszka Gren, Peter Massanyi
The goal of this study was to monitor the accumulation of aflatoxin B1 in the liver and kidney of brown hares (Lepus europaeus Pall) in the region of south-western Slovakia. A total of 65 samples were involved for analysis by RIA method. Brown hares were divided into the groups according to age, sex and season (month). The sex was determined visually after shooting, and the age was assigned from dried eye lens. The average concentration of AFB1 in the liver of hares was 0.54 ± 0.053 µg/kg, and lower values were measured in the kidney (0...
January 17, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/28089785/mechanistic-modelling-of-infrared-mediated-energy-transfer-during-the-primary-drying-step-of-a-continuous-freeze-drying-process
#4
Pieter-Jan Van Bockstal, Séverine Thérèse F C Mortier, Laurens De Meyer, Jos Corver, Chris Vervaet, Ingmar Nopens, Thomas De Beer
Conventional pharmaceutical freeze-drying is an inefficient and expensive batch-wise process, associated with several disadvantages leading to an uncontrolled end product variability. The proposed continuous alternative, based on spinning the vials during freezing and on optimal energy supply during drying, strongly increases process efficiency and improves product quality (uniformity). The heat transfer during continuous drying of the spin frozen vials is provided via non-contact infrared (IR) radiation. The energy transfer to the spin frozen vials should be optimised to maximise the drying efficiency while avoiding cake collapse...
January 12, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28077050/a-novel-human-like-collagen-hemostatic-sponge-with-uniform-morphology-good-biodegradability-and-biocompatibility
#5
Xijuan Jiang, Ya Wang, Daidi Fan, Chenhui Zhu, Lin Liu, Zhiguang Duan
Biodegradable sponges, as a promising hemostatic biomaterial, has been clinically required over the past decades. Current hemostatic sponges are generally prepared by crosslinking and freeze-drying, but the quality control or biocompatibility is often unsatisfactory due to the freezing-caused morphological non-uniformity and the toxicity of raw materials or cross-linkers. The crosslinking often greatly retards the degradation of the sponges and thus affects the healing of the wound. In this work, we prepared a novel hemostatic sponge using human-like collagen and glutamine transaminase (non-toxic cross-linker) and optimized its morphology via "two-step" freezing instead of conventional "one-step" freezing...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28070713/porous-mannitol-carrier-for-pulmonary-delivery-of-cyclosporine-a-nanoparticles
#6
Sharon Shui Yee Leung, Jennifer Wong, Heloisa Victorino Guerra, Kevin Samnick, Robert K Prud'homme, Hak-Kim Chan
This study employed the ultrasonic spray-freeze-drying technique to prepare porous mannitol carriers that incorporated hydrophobic cyclosporine A (CsA) nanoparticles (NPs) for pulmonary delivery. Two nanosuspension stabilization systems, (1) a combination of lecithin and lactose system and (2) a D-α-tocopheryl polyethylene glycol succinate (TPGS) system, were investigated. The ability of the lecithin and TPGS in anchoring the hydrophobic CsA NPs to the porous hydrophilic mannitol structure was first reported...
January 9, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28045246/macrofibers-with-high-mechanical-performance-based-on-aligned-bacterial-cellulose-nanofibers
#7
Jingjing Yao, Shiyan Chen, Ye Chen, Baoxiu Wang, Qibing Pei, Huaping Wang
Bacterial cellulose (BC) nanofibers represent an emerging class of highly crystalline bionanofibers with high intrinsic mechanical properties. The remarkable nanofibers with oriented structure and strong interfibrillar interactions can realize high-performance materials. In this study, we demonstrated that macrofibers based on aligned BC nanofibers could be prepared by wet spinning and drawing procedures. The relationship between process conditions, structure, and mechanical properties of macrofibers were investigated...
January 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28044462/freeze-drying-optimization-of-polymeric-nanoparticles-for-ocular-flurbiprofen-delivery-effect-of-protectant-agents-and-critical-process-parameters-on-long-term-stability
#8
Gladys Rosario Ramos Yacasi, Ana Cristina Calpena Capmany, María Antonia Egea Gras, Marta Espina García, María Luisa García López
CONTEXT: The stabilization of flurbiprofen loaded poly-Ɛ-caprolactone nanoparticles (FB-PƐCL-NPs) for ocular delivery under accurate freeze-drying (FD) process provide the basis for a large-scale production and its commercial development. OBJECTIVE: Optimization of the FD to improve long term stability of ocular administration's FB-PƐCL-NPs Methods: FB-PƐCL-NPs were prepared by solvent displacement method with poloxamer 188 (P188) as stabilizer. Freezing and primary dying (PD) were studied and optimized through freeze-thawing test and freeze-drying microscopy...
January 3, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28038750/a-tracheal-scaffold-of-gelatin-chondroitin-sulfate-hyaluronan-polyvinyl-alcohol-with-orientated-porous-structure
#9
Xueping Yu, Guowen Qian, Si Chen, Dong Xu, Xiujuan Zhao, Chang Du
Scaffold of gelatin-chondroitin sulfate-hyaluronan-polyvinyl alcohol (GCH-PVA) with orientated microtubule structure and good hydrophilicity was fabricated by unidirectional freeze-drying method mimicking the composition and structure of tracheal cartilage extracellular matrix. PVA was incorporated to improve flexibility and viscoelasticity of GCH scaffold. All wet scaffolds showed similar compressive elastic modulus with native cartilage. GCH-PVA scaffolds showed high relative remaining stress during relaxation indicating good mechanical stability...
March 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28033553/volumetric-absorptive-microsampling-vams-as-an-alternative-to-conventional-dried-blood-spots-in-the-quantification-of-miltefosine-in-dried-blood-samples
#10
A E Kip, K C Kiers, H Rosing, J H M Schellens, J H Beijnen, T P C Dorlo
Miltefosine is an oral agent against the neglected tropical disease leishmaniasis, which is mostly endemic in resource-poor areas. Dried blood spot (DBS) sampling is an attractive alternative to plasma sampling for pharmacokinetic studies in these remote areas, but introduces additional variability in analyte quantification due to possible blood spot inhomogeneity and variability in blood spot volume and haematocrit values. Volumetric absorptive microsampling (VAMS) potentially overcomes a few of these issues as the VAMS device absorbs a fixed volume that is processed as a whole...
December 9, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28026151/controlled-deposition-and-performance-optimization-of-perovskite-solar-cells-using-ultrasonic-spray-coating-photoactive-layers
#11
Wei-Chieh Chang, Ding-Hung Lan, Kun-Mu Lee, Xiao-Feng Wang, Cheng-Liang Liu
This study investigates novel film deposition technique, ultrasonic spray-coating, for use in photoactive layer of perovskite solar cell. Stable atomization and facile fabrication of perovskite thin film by ultrasonic spray-coating are achieved in an one-step method via manipulating the ink formulation such as solution concentration, precursor composition and mixing solvent ratio, and the drying kinetic such as post-annealing temperature. The performance of perovskite solar cells is mainly influenced by the intrinsic film morphology and crystalline orientation of the deposited perovskite layer...
December 27, 2016: ChemSusChem
https://www.readbyqxmd.com/read/28024261/simultaneous-hplc-assay-for-pretomanid-pa-824-moxifloxacin-and-pyrazinamide-in-an-inhaler-formulation-for-drug-resistant-tuberculosis
#12
Mohammad A M Momin, Sim J Thien, Woravimol Krittaphol, Shyamal C Das
A simple and sensitive reversed phase HPLC method has been developed for the simultaneous quantitation of pretomanid (PA-824), moxifloxacin and pyrazinamide in a combination spray-dried powder formulation for inhalation, without any use of an internal standard. Good resolution of the analytes was achieved on a Luna C18 (2), 150×4.6mm, 5μm, 100Å column using gradient elution with a mobile phase containing methanol and triethylamine phosphate buffer (pH 2.5) at a flow rate of 1.0mL/min in a total run time of 25min...
November 25, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28017550/a-novel-bioconversion-for-value-added-products-from-food-waste-using-musca-domestica
#13
Yi Niu, Dong Zheng, Binghua Yao, Zizhe Cai, Zhimin Zhao, Shengqing Wu, Peiqing Cong, Depo Yang
Food waste, as a major part of the municipal solid waste has been generated increasingly worldwide. Efficient and feasible utilization of this waste material for productivity process is significant for both economical and environmental reasons. In the present study, Musca domestica larva was used as the carrier to conduct a bioconversion with food waste to get the value-added maggot protein, oil and organic fertilizers. Methods of adult flies rearing, culture medium adjuvant selection, maggot culture conditions, stocking density and the valorization of the waste have been explored...
December 22, 2016: Waste Management
https://www.readbyqxmd.com/read/28012915/one-step-preparation-of-magnetic-recyclable-quinary-graphene-hydrogels-with-high-catalytic-activity
#14
Junshuai Zhang, Tongjie Yao, Chenchen Guan, Nanxi Zhang, Xin Huang, Tieyu Cui, Jie Wu, Xiao Zhang
Metal nanoparticles (NPs) displayed overwhelming superiority in catalysis towards the corresponding bulk-phase materials; nevertheless, how to further improve catalytic activity was still an ongoing subject. Herein, we have combined one-step redox reaction and following freeze-dried technology to construct the quinary reduced graphene oxide nanosheets (rGS)/Fe2O3-PdPt/polypyrrole (PPy) hydrogels. Compared with traditional catalysts, their catalytic property was improved via two ways: construction of three-dimensional (3D) rGS hydrogels instead of two-dimensional rGS and synthesis of bimetallic alloys instead of monometallic NPs...
December 12, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28011093/influence-of-different-stabilizers-on-the-encapsulation-of-desmopressin-acetate-into-plga-nanoparticles
#15
Daniel Primavessy, Nazende Günday-Türeli, Marc Schneider
To address targeting and bioavailability issues of peptidic drugs like desmopressin, the encapsulation into nanoparticles (NP) has become standard in pharmaceutics. This study investigated the encapsulation of desmopressin into PLGA NP by the use of pharmaceutically common stabilizers as a precursor to future, optional targeting and bioavailability experiments. Polymer dry weights were measured by freeze drying and thermo gravimetric analysis (TGA). Particle sizes (ranging between 105 and 130 nm, PDI < 0...
December 20, 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27998271/whole-genome-sequencing-of-plasmodium-falciparum-from-dried-blood-spots-using-selective-whole-genome-amplification
#16
Samuel O Oyola, Cristina V Ariani, William L Hamilton, Mihir Kekre, Lucas N Amenga-Etego, Anita Ghansah, Gavin G Rutledge, Seth Redmond, Magnus Manske, Dushyanth Jyothi, Chris G Jacob, Thomas D Otto, Kirk Rockett, Chris I Newbold, Matthew Berriman, Dominic P Kwiatkowski
BACKGROUND: Translating genomic technologies into healthcare applications for the malaria parasite Plasmodium falciparum has been limited by the technical and logistical difficulties of obtaining high quality clinical samples from the field. Sampling by dried blood spot (DBS) finger-pricks can be performed safely and efficiently with minimal resource and storage requirements compared with venous blood (VB). Here, the use of selective whole genome amplification (sWGA) to sequence the P...
December 20, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27995466/preparation-and-evaluation-of-diosgenin-nanocrystals-to-improve-oral-bioavailability
#17
Cui-Zhe Liu, Jin-Hua Chang, Lin Zhang, He-Fei Xue, Xi-Gang Liu, Pei Liu, Qiang Fu
Diosgenin (DSG), a well-known steroid sapogenin derived from Dioscorea nipponica Makino and Dioscorea zingiberensis Wright, has a variety of bioactivities. However, it shows low oral bioavailability due to poor aqueous solubility and strong hydrophobicity. The present study aimed to develop DSG nanocrystals to increase the dissolution and then improve the oral bioavailability and biopharmaceutical properties of DSG. DSG nanocrystals were prepared by the media milling method using a combination of pluronic F127 and sodium dodecyl sulfate as surface stabilizers...
December 19, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27990425/comparative-evaluation-of-anthelmintic-activity-of-edible-and-ornamental-pomegranate-ethanolic-extracts-against-schistosoma-mansoni
#18
Doaa A Yones, Dalia M Badary, Hesham M B Sayed, Soad A H Bayoumi, Azza A Khalifa, Ahmed M El-Moghazy
Due to the development of praziquantel (PZQ) schistosomes resistant strains, the discovery of new antischistosomal agents is of high priority in research. This work reported the in vitro and in vivo effects of the edible and ornamental pomegranate extracts against Schistosoma mansoni. Leaves and stem bark ethanolic extracts of both dried pomegranates were prepared at 100, 300, and 500 μg/mL for in vitro and 600 and 800 mg/kg for in vivo. Adult worms Schistosoma mansoni in RPMI-1640 medium for in vitro and S...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27987710/rapid-hemostatic-and-mild-polyurethane-urea-foam-wound-dressing-for-promoting-wound-healing
#19
Xiangyu Liu, Yuqing Niu, Kevin C Chen, Shiguo Chen
A novel rapid hemostatic and mild polyurethane-urea foam (PUUF) wound dressing was prepared by the particle leaching method and vacuum freeze-drying method using 4, 4-Methylenebis(cyclohexyl isocyanate), 4,4-diaminodicyclohexylmethane and poly (ethylene glycol) as raw materials. And X-ray diffraction (XRD), tensile test, differential scanning calorimetry (DSC) and thermogravimetry (TG) were used to its crystallinity, stress and strain behavior, and thermal properties, respectively. Platelet adhesion, fibrinogen adhesion and blood clotting were performed to evaluate its hemostatic effect...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27987515/-study-on-the-properties-of-felodipine-solid-dispersions-prepared-by-different-technologies
#20
N Q Shi, H Zhang, Y Zhang, B Feng, Z Q Li, X R Qi
OBJECTIVE: To prepare felodipine/copovidone solid dispersions, which were made based on different preparation technologies. Insoluble felodipine was selected as the model drug in this research. This drug belonged to Biopharmaceutics Classification System II (BCSII) with insoluble property and good permeability across intestinal mucosa simultaneously. A comparative study was carried out for further investigating their corresponding pharmaceutical properties. METHODS: Felodipine/copovidone solid dispersions were achieved by four methods including spray-drying method, microwave-induced fusion quench cooling method, freeze-drying method and co-precipitation method...
December 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
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