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Danial Zarringam, Joris E J Bekkers, Daniel B F Saris
Background Orthokin is an intra-articular autologous conditioned serum (ACS). Its use might have a beneficial biological effect on pain and function of osteoarthritis in the knee. However, earlier studies lack any consensus on its clinical application and disease modifying effect. Objective The aim of this study was to investigate the long-term effect of Orthokin injection treatment on prevention of surgical treatment for end-stage knee osteoarthritis. Study Design Prospective cohort study. Methods Patients of the previously published Orthokin cohort were contacted to determine whether any intra-articular surgical intervention or osteotomy of the study knee had taken place during the past decade...
April 2018: Cartilage
Zahra Javanmardi, Parisa Salehi
Background. Elastomeric chains and NiTi coil springs are two major traction aids in orthodontic tooth movements. Force degradation occurs over time in both groups, with higher percentages in elastic chains. The effects of environmental factors and some mouth rinses on this force decay have been previously studied. No study has been performed to evaluate the effect of current popular mouth rinses such as Orthokin, Sensikin and Persica on this force degradation. Methods . Forty pieces of elastic chains consisting of 5 loops (Ortho Technology, USA) and 40 NiTi closed coil springs (3M Unitek, Germany) were divided into 4 groups: control (artificial saliva), Orthokin mouthwash, Sensikin mouthwash and Persica mouthwash...
2016: Journal of Dental Research, Dental Clinics, Dental Prospects
Dominique M Sawyere, Otto I Lanz, Linda A Dahlgren, Sabrina L Barry, Anne C Nichols, Stephen R Werre
OBJECTIVE: To compare cytokine and growth factor concentrations in canine autologous conditioned serum (ACS) to canine plasma. STUDY DESIGN: Experimental in vivo study. ANIMALS: Client-owned, adult dogs (n=22). METHODS: Blood collected from 16 medium to large breed dogs was used to produce ACS (Orthokine(®) vet irap 10 syringes) and citrated plasma (control). Canine-specific ELISA assays were run per manufacturers' instructions for interleukin (IL)-10, IL-4, tumor necrosis factor (TNF)-α, insulin-like growth factor (IGF)-1, fibroblast growth factor (FGF)-2, transforming growth factor (TGF)-β1, IL-1β, and interleukin-1 receptor antagonist (IL-1ra)...
July 2016: Veterinary Surgery: VS
Piotr Godek
BACKGROUND: The aim of the study was to determine the usefulness of autologous serum in the treatment of patients with signs of radicular compression in the course of lumbar discopathy. The treatment was based on the use of autologous conditioned serum (ACS, Orthokine). MATERIAL AND METHODS: A total of 15 patients with MRI-confirmed single-level nucleus pulposus herniation with signs of radicular compression without paresis in a clinical examination received 6 doses of ACS administered by the same doctor under ultrasound guidance from a posterolateral approach to the area of an intervertebral foramen...
January 2016: Ortopedia, Traumatologia, Rehabilitacja
Deepan N Patel, Eric J Strauss
Bone marrow aspirate, prolotherapy, platelet-rich plasma,and autologous conditioned serum represent alternative treatment options that have emerged to address various musculoskeletal ailments. We have reviewed the basic science, physiology, and clinical evidence of each of these modalities and discovered that each treatment has its individual place in the management of common orthopaedic pathologies. Bone marrow aspirates are successful in treating early arthritis and cartilage defects. Prolotherapy and platelet-rich plasma have demonstrated good efficacy in treating inflammatory processes and early arthritis...
June 2015: Bulletin of the Hospital for Joint Diseases
Abdolreza Jamilian, Omid Moghaddas, Shabnam Toopchi, Letizia Perillo
AIM: Oral environment of the mouth is a suitable place for biodegradation of alloys used in orthodontic wires. The toxicity of these alloys namely nickel and chromium has concerned the researchers about the release of these ions from orthodontic wires and brackets. The aim of this study was to measure the levels of nickel and chromium ions released from 0.018" stainless steel (SS) and NiTi wires after immersion in three solutions. MATERIALS AND METHODS: One hundred and forty-four round NiTi and 144 round SS archwires with the diameters of 0...
July 2014: Journal of Contemporary Dental Practice
Juan-Carlos Alvarez-Camino, Eduardo Vázquez-Delgado, Cosme Gay-Escoda
OBJECTIVES: Treatment of osteoarthritis (OA) using autologous conditioned serum (ACS) has become in recent years an alternative to consider in the approach of the degenerative joint disease of the knee. There is no support in the literature for the use of ACS for the treatment of OA of the temporomandibular joint (TMJ), although the promising results obtained in human patients with knee joint disease and in animal studies are opening the way for its use at the TMJ. The aim of this paper is to conduct a review of the published literature regarding the use of the ACS for the treatment of OA in humans, considering the level of scientific evidence, and following the principles of the evidence-based medicine and dentistry...
May 2013: Medicina Oral, Patología Oral y Cirugía Bucal
Beth Anne Fox, Mary M Stephens
Osteoarthritis (OA) is the most prevalent arthritis in the world with increasing numbers of people expected to acquire the disease as the population ages. Therapies commonly used to manage the disease have limited efficacy and some carry significant risks. Current data suggest that the anti-inflammatory cytokine IL-1 receptor antagonist (IL-1Ra) can alter the inflammatory response and cartilage erosion present in OA. Intra-articular gene expression of IL-1Ra has shown promising results in animal models to provide symptomatic improvement and minimize osteoarthritic changes...
May 2010: Expert Review of Clinical Immunology
U Heyll
No abstract text is available yet for this article.
September 1, 2009: Versicherungsmedizin
S Rehart, G Burmester, C Schwab et al.
No abstract text is available yet for this article.
October 25, 2009: Zeitschrift Für Rheumatologie
A W A Baltzer, C Moser, S A Jansen, R Krauspe
OBJECTIVE: Osteoarthritis (OA) is prevalent and difficult to treat. Autologous conditioned serum (ACS), marketed under the trade name Orthokine, is a novel, injectable antiarthritic derived from the patient's own blood. The present study is the first time ACS has undergone a controlled clinical trial. METHOD: We investigated 376 patients with knee OA in a prospective, randomized, patient- and observer-blinded, placebo-controlled trial using an intention-to-treat analysis (ITT)...
February 2009: Osteoarthritis and Cartilage
Peter Wehling, Carsten Moser, David Frisbie, C Wayne McIlwraith, Christopher E Kawcak, Ruediger Krauspe, Julio A Reinecke
The common strategies for the treatment of patients with orthopedic diseases do not address the underlying pathogenesis. Several biologically based, local therapies aiming to influence the cytokine imbalance are either in development or in the initial stages of clinical use. A method based on exposure of blood leukocytes to pyrogen-free surfaces (e.g. glass spheres) elicits an accumulation of anti-inflammatory cytokines, including interleukin-1 receptor antagonist, and several growth factors, including insulin-like growth factor-1, platelet-derived growth factor, and transforming growth factor-beta(1), in the liquid blood phase...
2007: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
K G Auw Yang, N J H Raijmakers, E R A van Arkel, J J Caron, P C Rijk, W J Willems, J A C Zijl, A J Verbout, W J A Dhert, D B F Saris
INTRODUCTION: Incubation of blood with CrSO(4)-coated glass beads stimulates the synthesis of anti-inflammatory cytokines, such as interleukin-1 receptor antagonist (IL-1ra), IL-4, IL-10, and IL-13. As IL-1beta is thought to play a key role in the development of osteoarthritis (OA), this product, also known as Orthokin, might be a viable treatment for symptomatic knee OA. The aim of the current study was to evaluate the efficacy of Orthokin for treatment of symptomatic knee OA in a randomized, multicentre, double-blind, placebo-controlled trial...
April 2008: Osteoarthritis and Cartilage
Cordelia Becker, Stefan Heidersdorf, Sascha Drewlo, Sonja Zirke de Rodriguez, Juergen Krämer, Roland Ernst Willburger
STUDY DESIGN: Prospective, double-blind, reference-controlled, investigator-initiated, single center. OBJECTIVE: To evaluate the efficacy of Autologous Conditioned Serum (ACS; Orthokine) for the treatment of lumbar radicular compression in comparison to triamcinolone. SUMMARY OF BACKGROUND DATA: Evidence from animal studies indicates that cytokines such as interleukin-1 play a decisive role in the pathophysiology of lumbar radiculopathy. ACS is enriched in the interleukin-1 receptor antagonist and other anti-inflammatory cytokines...
August 1, 2007: Spine
G R Burmester, J Grifka et al.
Due to the public discussion on the drug "Orthokin", the Commission for Pharmacotherapy of the German Society for Rheumatology (Deutschen Gesellschaft für Rheumatologie, DGRh) has summarized the relevant data. An unpublished study with 400 patients shows an advantage for Orthokin compared to either hyaluronic acid or a placebo for the treatment of osteoarthritis related chronic knee pain. Until these data have been published in an appropriate specialist journal, it is not possible for the DGRh to give a recommendation...
February 2007: Zeitschrift Für Rheumatologie
Christopher H Evans
Osteoarthritis is common, incurable and difficult to treat. Because osteoarthritis is symptomatic only in a limited number of weight-bearing joints and lacks obvious extra-articular manifestations, it is well suited to local therapy administered by intra-articular injection. Several biologically based, local therapies of this type are either in clinical use or in development. Intra-articular injections of hyaluronic acid are widely used, but are highly controversial because their mode of action is unclear and clinical trials have provided contradictory results...
2005: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
Manuel Toledano, Raquel Osorio, Estrella Osorio, Fátima S Aguilera, Alejandro Romeo, Blanca de la Higuera, Franklin García-Godoy
To evaluate and compare the solubility and sorption of orthodontic bonding cements after immersion in different solutions, five different cements were used: a fluoride-containing resin composite, a light-cured glass ionomer cement, a light-cured resin composite, a paste-paste chemically cured resin composite, and a liquid-paste chemically cured resin composite. Five different solutions were employed: distilled water, artificial saliva, an alcohol-free mouthrinse solution (Orthokin), a 5% alcohol mouthrinse solution (Perioaid), and a 75% ethanol/water solution...
February 2006: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
U Heyll
The synthesis and introduction of interleukin-1 receptor antagonists established a promising strategy in the treatment of inflammatory diseases. This kind of therapy is claimed now to be available for osteoarthritis and other orthopedic disorders also. In the case of "orthokin", the interleukin-1 receptor antagonist is produced by stimulation of own blood-cells. It is not possible, to evaluate the practicability of this therapeutic approach because there are no published experimental data. We also found no results of clinical studies, which would allow an estimation of the effectiveness and the risks of this method...
March 1, 2004: Versicherungsmedizin
H Meijer, J Reinecke, C Becker, G Tholen, P Wehling
OBJECTIVE AND DESIGN: Cytokines such as interleukin-1 (IL-1) play an important role in degenerative musculo-skeletal diseases, including osteoarthritis, and a multitude of inflammatory disorders. Agents that inhibit the action of such cytokines have a high therapeutic potential in such diseases. Here we describe a new method for enhancing the production of the interleukin-l receptor antagonist (IL-1Ra) and other anti-inflammatory cytokines in whole blood. MATERIAL AND METHODS: Human venous blood was incubated in the presence of CrSO(4)-treated glass beads...
October 2003: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
J Steinmeyer
Osteoarthritis is one of the most common and economically important chronic diseases amongst adults, especially those of a senior age. There now exists a range of effective medications, which either alone or in combination can alleviate the symptoms of the disease and improve the quality of life. Because these medications are not always sufficiently effective and must sometimes be interrupted due to side effects, a large arsenal of active agents is necessary. Alleviation of pain and inhibition of inflammation are the primary goals of pharmacotherapy, whereby the objective is to return an active or transiently painful, decompensated osteoarthritis to a latent (silent, pain-free) condition...
November 2001: Der Orthopäde
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