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Spleen elastography

Hanno Ehlken, Raluca Wroblewski, Christophe Corpechot, Lionel Arrivé, Tim Rieger, Johannes Hartl, Susanne Lezius, Peter Hübener, Kornelius Schulze, Roman Zenouzi, Marcial Sebode, Moritz Peiseler, Ulrike W Denzer, Alexander Quaas, Christina Weiler-Normann, Ansgar W Lohse, Olivier Chazouilleres, Christoph Schramm
BACKGROUND: Patients with primary sclerosing cholangitis (PSC) develop progressive liver fibrosis and end-stage liver disease. Non-invasive and widely available parameters are urgently needed to assess disease stage and the risk of clinical progression. Transient elastography (TE) has been reported to predict fibrosis stage and disease progression. However, these results have not been confirmed in an independent cohort and comparison of TE measurement to other non-invasive means is missing...
2016: PloS One
Florian Dittmann, Heiko Tzschätzsch, Sebastian Hirsch, Eric Barnhill, Jürgen Braun, Ingolf Sack, Jing Guo
PURPOSE: To develop a compact magnetic resonance elastography (MRE) protocol for abdomen and to investigate the effect of water uptake on tissue stiffness in the liver, spleen, kidney, and pancreas. METHODS: Nine asymptomatic volunteers were investigated by MRE before and after 1 liter water uptake. Shear-wave excitation at four frequencies was transferred to the abdomen from anterior and posterior directions using pressurized air drivers. Tomographic representations of shear-wave speed were produced by analysis of multifrequency wave numbers in axial and coronal images acquired within four breath-holds or under free breathing, respectively...
October 3, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Aparna Srinivasa Babu, Michael L Wells, Oleg M Teytelboym, Justin E Mackey, Frank H Miller, Benjamin M Yeh, Richard L Ehman, Sudhakar K Venkatesh
Chronic liver disease has multiple causes, many of which are increasing in prevalence. The final common pathway of chronic liver disease is tissue destruction and attempted regeneration, a pathway that triggers fibrosis and eventual cirrhosis. Assessment of fibrosis is important not only for diagnosis but also for management, prognostic evaluation, and follow-up of patients with chronic liver disease. Although liver biopsy has traditionally been considered the reference standard for assessment of liver fibrosis, noninvasive techniques are the emerging focus in this field...
September 30, 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
Mariangela Giunta, Dario Conte, Mirella Fraquelli
The development of liver cirrhosis and portal hypertension (PH), one of its major complications, are structural and functional alterations of the liver, occurring in many patients with chronic liver diseases (CLD). Actually the progressive deposition of hepatic fibrosis has a key role in the prognosis of CLD patients. The subsequent development of PH leads to its major complications, such as ascites, hepatic encephalopathy, variceal bleeding and decompensation. Liver biopsy is still considered the reference standard for the assessment of hepatic fibrosis, whereas the measurement of hepatic vein pressure gradient is the standard to ascertain the presence of PH and upper endoscopy is the method of choice to detect the presence of oesophageal varices...
September 21, 2016: World Journal of Gastroenterology: WJG
Maya Balakrishnan, Fernanda Souza, Carolina Muñoz, Salvador Augustin, Nicole Loo, Yanhong Deng, Maria Ciarleglio, Guadalupe Garcia-Tsao
OBJECTIVES: Measurements of liver stiffness and spleen stiffness are useful noninvasive ways to assess fibrosis and portal hypertension in patients with chronic liver disease. One method for assessing stiffness is by point shear wave elastography via acoustic radiation force impulse imaging (ARFI). Its advantage is that sites where stiffness is measured are visualized sonographically. However, its reliability has not been well established, and all studies done to date evaluating the use of ARFI in chronic liver disease have been performed outside the United States...
September 23, 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Juan G Abraldes, Christophe Bureau, Horia Stefanescu, Salvador Augustin, Michael Ney, Hélène Blasco, Bogdan Procopet, Jaime Bosch, Joan Genesca, Annalisa Berzigotti
In patients with compensated advanced chronic liver disease (cACLD) the presence of clinically significant portal hypertension (CSPH) and varices needing treatment (VNT) bears prognostic and therapeutic implications. Our aim was to develop non-invasive tests based risk prediction models to provide a point-of-care risk assessment of cACLD patients. We analyzed 518 patients with cACLD from 5 centers in Europe/Canada with paired non-invasive tests (liver stiffness by transient elastography(LSM), platelet count and spleen diameter with calculation of LSPS score and platelet-spleen ratio (PSR)) and endoscopy/HVPG measurement...
September 17, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Christian Jansen, Christopher Bogs, Wim Verlinden, Maja Thiele, Philipp Möller, Jan Görtzen, Jennifer Lehmann, Thomas Vanwolleghem, Luisa Vonghia, Michael Praktiknjo, Johannes Chang, Aleksander Krag, Christian P Strassburg, Sven Francque, Jonel Trebicka
BACKGROUND AND AIMS: Clinically significant portal hypertension (CSPH) is associated with severe complications and decompensation of liver cirrhosis. Liver stiffness measured either by transient elastography (TE) or Shear-wave elastography (SWE) and spleen stiffness by TE might be helpful in the diagnosis of CSPH. We recently showed the algorithm to rule-out CSPH by using sequential liver- (L-SWE) and spleen-Shear-wave elastography (S-SWE). This study investigated the diagnostic value of S-SWE for diagnosis of CSPH...
August 29, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
Heiko Tzschätzsch, Manh Nguyen Trong, Tobias Scheuermann, Selcan Ipek-Ugay, Thomas Fischer, Michael Schultz, Jürgen Braun, Ingolf Sack
Measurement of shear wave speed of the liver and spleen by elastography is an established diagnostic procedure for the detection of hepatic fibrosis, portal hypertension and esophageal varices. However, current elastography systems are limited by the size and penetration depth of elastographic windows. In this study, 2D time-harmonic elastography is proposed for generating full field-of-view shear wave speed maps in great depth. Two-dimensional time-harmonic elastography uses external harmonic stimulation at multiple frequencies to create compound shear wave speed maps...
November 2016: Ultrasound in Medicine & Biology
Aleksander Pawluś, Marcin Inglot, Mariusz Chabowski, Kinga Szymańska, Małgorzata Inglot, Mateusz Patyk, Joanna Słonina, Filipe Caseiro-Alves, Dariusz Janczak, Urszula Zaleska-Dorobisz
OBJECTIVE: The aim of the study was to compare the elasticity of the spleen in patients with hepatitis B and C but without liver fibrosis with that of healthy subjects using a shear wave elastography (SWE) examination. METHODS: Between December 2014 and December 2015, 35 patients with hepatitis B virus (HBV) infections and 45 patients with (hepatitis C virus) HCV infections and liver stiffness below 7.1 kPa were included in the study. The control group was composed of 53 healthy volunteers without any chronic liver disease, with no abnormal findings in their ultrasound examinations and with an SWE of the liver below 6...
October 2016: British Journal of Radiology
V Knop, D Hoppe, T Welzel, J Vermehren, E Herrmann, A Vermehren, M Friedrich-Rust, C Sarrazin, S Zeuzem, M-W Welker
It is still controversial, whether and to what amount cirrhosis and portal hypertension are reversible in patients with hepatitis C virus (HCV)-associated cirrhosis and sustained virologic response (SVR) after interferon-free antiviral therapy. In this study, we prospectively evaluated dynamics of liver and spleen stiffness in HCV-infected patients with advanced liver disease and SVR after interferon-free treatment. A total of 54 patients with HCV-associated cirrhosis and SVR were included. Liver and spleen stiffness was measured at therapy baseline (BL), end of treatment (EOT) and 24 weeks after EOT (FU24) by transient liver elastography (L-TE) as well as by acoustic radiation force impulse of the liver (L-ARFI) and spleen (S-ARFI), as well as biochemical, virologic and clinical data...
August 8, 2016: Journal of Viral Hepatitis
Laura Kassym, Mohammed A Nounou, Zauresh Zhumadilova, Asad I Dajani, Nurgul Barkibayeva, Ayan Myssayev, Tolebay Rakhypbekov, Adnan M Abuhammour
BACKGROUND: The diagnosis of chronic liver disease (CLD) leading to fibrosis, cirrhosis, and portal hypertension had witnessed dramatic changes after the introduction of noninvasive figure accessible tools over the past few years. Imaging techniques that are based on evaluation of the liver stiffness was particularly useful in this respect. Acoustic radiation force impulse (ARFI) emerged as an interesting figure tool with reliable repute and high precision. AIMS: To evaluate liver stiffness measurement (LSM) and splenic stiffness measurement (SSM) in healthy volunteers as concluded by the ARFI technique and to out a numeric calculated ratio that may reflect their correlation in the otherwise healthy liver...
July 2016: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
Aleksander Pawluś, Marcin S Inglot, Kinga Szymańska, Krzysztof Kaczorowski, Bartosz D Markiewicz, Agnieszka Kaczorowska, Jacek Gąsiorowski, Aleksandra Szymczak, Małgorzata Inglot, Joanna Bladowska, Urszula Zaleska-Dorobisz
PURPOSE: The aim of this study was to assess the mean value of spleen stiffness measured by Shear wave elastography in healthy patients and its dependence on age, sex, and spleen dimensions, and to evaluate the repeatability of this method. METHODS: The final study group included 59 healthy volunteers without any clinical evidence of liver disease, portal hypertension, hematological disorders, and without any pathological ultrasonographic spleen findings. Each patient underwent abdominal ultrasound examination and elastography of the liver and the spleen...
July 7, 2016: Abdominal Radiology
Cheng-Hung Chien, Yi-Lan Lin, Rong-Nan Chien, Ching-Chih Hu, Cho-Li Yen, Tsung-Shih Lee, Po-Jen Hsieh, Chih-Lang Lin
OBJECTIVES: The purpose of our study was to evaluate the relationship between spleen stiffness measured by transient elastography and the degree of thrombocytopenia in patients with liver cirrhosis. METHODS: A total of 67 patients with liver cirrhosis were prospectively enrolled in the study. All patients underwent single-day hematologic and biochemical tests, sonography, and transient elastography of the liver and spleen. Thrombocytopenia was categorized as mild (platelet count, 75,000-150,000/μL), moderate (50,000-75,000/μL), and severe (<50,000/μL)...
September 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Alessandra Iurlo, Daniele Cattaneo, Mariangela Giunta, Umberto Gianelli, Mirella Fraquelli, Agostino Cortelezzi
No abstract text is available yet for this article.
September 2016: Ultrasound Quarterly
Anders Batman Mjelle, Anesa Mulabecirovic, Trygve Hausken, Roald Flesland Havre, Odd Helge Gilja, Mette Vesterhus
Point shear wave elastography (pSWE) is an ultrasound-based method for non-invasive quantification of liver fibrosis. The objective of this study was to explore liver pSWE in patients with primary sclerosing cholangitis (PSC) for assessment of fibrosis. Fifty-five non-transplant patients with PSC (38 males, 17 females; mean age: 46.4 y) were included and compared with 24 matched controls. Median (range) PSC duration was 8.1 (0-33) y. Ultrasonographic scanning followed by liver stiffness measurement by pSWE was performed using a conventional ultrasound system (Philips iU22)...
September 2016: Ultrasound in Medicine & Biology
Tae Yoon Kim, Tae Yeob Kim, Yongsoo Kim, Sanghyeok Lim, Woo Kyoung Jeong, Joo Hyun Sohn
OBJECTIVES: The purpose of this study was to investigate the diagnostic performance of shear wave elastography (SWE) for predicting the presence of esophageal varices and high-risk esophageal varices in patients with compensated cirrhosis and to compare it with other nonspecific predictors and according to the presence of splenomegaly. METHODS: Clinical data from 103 patients with compensated cirrhosis who underwent sonography, SWE, and endoscopy were collected consecutively...
July 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Grace Lai-Hung Wong, Raymond Kwok, Henry Lik-Yuen Chan, Stephen Pui-Kit Tang, Eugenia Lee, Thomas Chi-Ho Lam, Tiffany Wing-Yan Lau, Teresa Man-Kee Ma, Betsy Chi-Kuen Wong, Vincent Wai-Sun Wong
BACKGROUND & AIMS: The accuracy of liver and spleen stiffness measurement (LSM & SSM) with transient elastography to predict varices in the presence of non-selective beta-blockers (NSBB) has never been studied before. METHODS: This was a cross-sectional study of consecutive patients with chronic hepatitis B (CHB) and cirrhosis. All patients underwent transient elastography and upper endoscopic examinations. Performance of LSM and SSM to predict varices in patients did and did not receive NSBB was evaluated...
May 17, 2016: Journal of Digestive Diseases
Romanas Zykus, Laimas Jonaitis, Vitalija Petrenkienė, Andrius Pranculis, Limas Kupčinskas
No abstract text is available yet for this article.
2016: BMC Gastroenterology
Silja Voutilainen, Reetta Kivisaari, Jouko Lohi, Hannu Jalanko, Mikko P Pakarinen
GOALS AND BACKGROUND: We compared liver stiffness (LS), the aspartate aminotransferase-to-platelet ratio index (APRi), and the platelet-to-spleen size z score ratio (P/SZC) in the prediction of liver fibrosis and esophageal varices in children. STUDY: LS, APRi, SZC, and P/SZC were prospectively determined in 99 unselected consecutive children, who underwent liver biopsy for the follow-up of chronic liver disorders. LS was assessed by transient elastography. The spleen size was evaluated as the SD from age-specific and gender-specific normative values...
September 2016: Journal of Clinical Gastroenterology
Jing Gao, Xiao Zheng, Yuan-Yi Zheng, Guo-Qing Zuo, Hai-Tao Ran, Yong Ho Auh, Levi Waldron, Tiffany Chan, Zhi-Gang Wang
OBJECTIVES: To assess the feasibility of splenic shear wave elastography in monitoring transjugular intrahepatic portosystemic shunt (TIPS) function. METHODS: We measured splenic shear wave velocity (SWV), main portal vein velocity (PVV), and splenic vein velocity (SVV) in 33 patients 1 day before and 3 days to 12 months after TIPS placement. We also measured PVV, SVV, and SWV in 10 of 33 patients with TIPS dysfunction 1 day before and 3 to 6 days after TIPS revision...
May 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
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