keyword
MENU ▼
Read by QxMD icon Read
search

cancer and folic acid

keyword
https://www.readbyqxmd.com/read/28081459/targeted-delivery-of-in-situ-pcr-amplified-sleeping-beauty-transposon-genes-to-cancer-cells-with-lipid-based-nanoparticle-like-protocells
#1
Kun Ma, Duo Fu, Dongli Yu, Changhao Cui, Li Wang, Zhaoming Guo, Chuanbin Mao
A Sleeping Beauty (SB) transposon system is made of a transposon plasmid (containing gene encoding a desired functional or therapeutic protein) and a transposase plasmid (encoding an enzyme capable of cutting and pasting the gene into the host cell genome). It is a kind of natural, nonviral gene delivery vehicle, which can achieve efficient genomic insertion, providing long-term transgenic expression. However, before the SB transposon system could play a role in promoting gene expression, it has to be delivered efficiently first across cell membrane and then into cell nuclei...
January 2, 2017: Biomaterials
https://www.readbyqxmd.com/read/28079361/controllable-synthesis-of-smart-multifunctional-nanoscal-metal-organic-framework-for-magnetic-resonance-optical-imaging-and-targeted-drug-delivery
#2
Xuechuan Gao, Manjue Zhai, Weihua Guan, Jingjuan Liu, Zhiliang Liu, Alatangaole Damirin
As a result of their extraordinarily large surfaces and well-defined pores, the design of multifunctional metal-organic framework (MOF) is crucial for drug delivery while has been rarely reported. In this paper, a novel drug delivery system (DDS) based on nanoscale metal-organic framework (MOF) was developed for using in cancer diagnosis and therapy. This MOF based tumour targeting DDS was fabricated by a simple post-synthetic surface modification process. Firstly, magnetic mesoporous nanomaterial Fe-MIL-53-NH2 was devoted for encapsulating the drug and served as a magnetic resonance (MR) contrast agent...
January 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28073680/rationale-and-design-of-pemvitastart-an-open-label-randomized-trial-comparing-simultaneous-versus-standard-initiation-of-vitamin-b12-and-folate-supplementation-in-nonsquamous-non-small-cell-lung-cancer-patients-undergoing-first-line-pemetrexed-based-chemotherapy
#3
Milind Baldi, Digambar Behera, Jyotdeep Kaur, Rakesh Kapoor, Navneet Singh
Pemetrexed is the preferred chemotherapeutic drug for nonsquamous, non-small-cell lung cancer patients whenever the predictive molecular biomarkers for targeted therapy have either not been assessed or are absent. As per manufacturers' instructions, supplementation with folic acid (FA; folate) at a dose of 350 to 1000 μg daily should be started seven days before the first dose of pemetrexed-based chemotherapy and continued during therapy and for 21 days after therapy cessation. Vitamin B12 injections (1000 μg intramuscularly) should also be started one week before the first dose of chemotherapy...
December 2, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28058423/rapidly-cell-penetrating-and-reductive-milieu-responsive-nanoaggregates-assembled-from-an-amphiphilic-folate-camptothecin-prodrug-for-enhanced-drug-delivery-and-controlled-release
#4
Zhigang Xu, Meili Hou, Xiaoxiao Shi, Yong-E Gao, Peng Xue, Shiying Liu, Yuejun Kang
Accurate diagnosis and treatment based on small molecular prodrugs can enhance drug efficiency and reduce side-effects during cancer therapy. Herein, we report the preparation of a type of glutathione (GSH)-responsive small prodrug delivery system based on targeting folic acid (FA) and conjugating with the hydrophobic antitumor drug camptothecin (CPT) via disulfide bonds. The obtained prodrug is capable of high and precise drug loading (36.8 wt%) and can self-assemble into nanoaggregates with an average size of 46...
January 6, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28054353/factors-related-to-pregnancy-and-birth-and-the-risk-of-childhood-brain-tumours-the-estelle-and-escale-studies-sfce-france
#5
Helen D Bailey, Paula Rios, Brigitte Lacour, Lea Guerrini-Rousseau, Anne-Isabelle Bertozzi, Pierre Leblond, Cécile Faure-Conter, Isabelle Pellier, Claire Freycon, Jean Michon, Stéphanie Puget, Stéphane Ducassou, Laurent Orsi, Jacqueline Clavel
Little is known of the causes of childhood brain tumors (CBT). The aims of this study were to investigate whether extremes of birth weight were associated with increased risk of CBT and whether maternal pre-conceptional folic acid supplementation or breastfeeding reduced the risk. In addition, other maternal characteristics and birth related factors were also investigated. We pooled data from two French national population-based case-control studies with similar designs conducted in 2003-2004 and 2010-2011...
January 5, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28050902/erythrocyte-membrane-coated-upconversion-nanoparticles-with-minimal-protein-adsorption-for-enhanced-tumor-imaging
#6
Lang Rao, Qian-Fang Meng, Lin-Lin Bu, Bo Cai, Qinqin Huang, Zhi-Jun Sun, Wen-Feng Zhang, Andrew Li, Shi-Shang Guo, Wei Liu, Tza-Huei Wang, Xing-Zhong Zhao
Upconversion nanoparticles (UCNPs) with superior optical and chemical features have been broadly employed for in vivo cancer imaging. Generally, UCNPs are surface modified with ligands for cancer active targeting. However, nanoparticles in biological fluids are known to form a long-lived "protein corona", which covers the targeting ligands on nanoparticle surface and dramatically reduces the nanoparticle targeting capabilities. Here, for the first time, we demonstrated that by coating UCNPs with red blood cell (RBC) membranes, the resulting cell membrane-capped nanoparticles (RBC-UCNPs) adsorbed virtually no proteins when exposed to human plasma...
January 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28050621/-a-two-faced-vitamin-folic-acid-prevention-or-promotion-of-colon-cancer
#7
Anke Weißenborn, Anke Ehlers, Karen-I Hirsch-Ernst, Alfonso Lampen, Birgit Niemann
In the late 1930s, it was discovered that liver and yeast extracts can be used to correct certain cases of megaloblastic anemia in pregnancy. The factor responsible for this was isolated from spinach leaves in the 1940s, and referred to as folate, a term derived from the Latin word folium for leaf. Folate is considered an essential nutrient for human beings. Folic acid, the synthetic form of the vitamin, is used in dietary supplements, medicines and fortified foods. Since the 1980s, it has been recommended that women who plan to become pregnant and pregnant women during the first trimester of pregnancy take folic acid supplements...
January 3, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28045918/response-of-mirna-22-3p-and-mirna-149-5p-to-folate-deficiency-and-the-differential-regulation-of-mthfr-expression-in-normal-and-cancerous-human-hepatocytes
#8
Chao Li, Juan Ni, Yao-Xian Liu, Han Wang, Zi-Qing Liang, Xu Wang
BACKGROUND/AIMS: Folic acid (FA) is a core micronutrient involved in DNA synthesis/methylation, and the metabolism of FA is responsible for genomic stability. MicroRNAs may affect gene expression during folate metabolism when cellular homeostasis is changed. This study aimed to reveal the relationship between FA deficiency and the expression of miR-22-p/miR-149-5p and the targeted regulation of miR-22-3p/miR-149-5p on the key folate metabolic gene Methylenetetrahydrofolate reductase (MTHFR)...
2017: PloS One
https://www.readbyqxmd.com/read/28042941/a-ph-responsive-self-sacrificial-nanotheranostic-agent-for-potential-in-vivo-and-in-vitro-dual-modal-mri-ct-imaging-real-time-and-in-situ-monitoring-of-cancer-therapy
#9
Ludan Yue, Jinlong Wang, Zhichao Dai, Zunfu Hu, Xue Chen, Yafei Qi, Xiuwen Zheng, Dexin Yu
Multifunctional nanotheranostic agents have been highly commended due to the application to realize image-guided cancer therapy. Herein, based on the chemically disordered face centered cubic (fcc) FePt nanoparticles (NPs) and graphene oxide(GO), we develop a pH-responsive FePt-based multifunctional theranostic agent for potential in vivo and in vitro dual modal MRI/CT imaging and in-situ cancer inhibition. The fcc-FePt will release highly active Fe ions due to the low pH in tumor cells, which would catalyze H2O2 decomposition into reactive oxygen species (ROS) within the cells and further induce cancer cell apoptosis...
January 2, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28040391/light-induced-drug-release-from-a-folic-acid-drug-conjugate
#10
M Michael Dcona, Jonathon E Sheldon, Deboleena Mitra, Matthew C T Hartman
A major area of cancer research focuses on improving the specificity of therapeutic agents by engineering drug-delivery vehicles that target overexpressed receptors on tumor cells. One of the most commonly used approaches involves targeting of folate receptors using folic acid conjugated to a drug-containing macromolecular cargo. Once internalized via endocytosis, the drugs must be released from these constructs in order to avoid being trapped in the endosomes. Here, we describe the synthesis of a small-molecule conjugate that couples folic acid to doxorubicin via a photocleavable linker...
December 18, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28033467/multifunctional-metal-organic-framework-nanoprobe-for-cathepsin-b-activated-cancer-cell-imaging-and-chemo-photodynamic-therapy
#11
Jintong Liu, Lei Zhang, Jianping Lei, Hong Shen, Huangxian Ju
Integration of a photodynamic therapy platform with a drug-delivery system in a porous structure is an urgent challenge for enhanced anticancer therapy. Here, an amino-functionalized metal-organic framework (MOF), which is useful as efficient delivery vehicle for drugs and provides the -NH2 group for postsynthetic modification, is chosen and well-designed for cell imaging and chemo-photodynamic therapy. The multifunctional MOF nanoprobe was first assembled with camptothecine drug via noncovalent encapsulation and then bound with folic acid as the targeted element and chlorine e6 (Ce6)-labeled CaB substrate peptide as the recognition moiety and signal switch...
January 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28024576/resveratrol-loaded-folic-acid-grafted-dextran-stearate-submicron-particles-exhibits-enhanced-antitumor-efficacy-in-non-small-cell-lung-cancers
#12
Qing-Sheng Zhao, Ling-Ling Hu, Zhi-Dong Wang, Zhao-Pei Li, Ai-Wen Wang, Jing Liu
In this study, we have aimed to prepare folic acid-conjugated dextran stearate (DF) polymeric micelles to target resveratrol in lung cancers. The polymeric micelle was nanosized and exhibited a controlled drug release pattern. The resveratrol (RSV)-loaded dextran stearate (RSV-DF) micelles exhibited an enhanced cellular uptake in A549 cells due to the folic acid-based receptor interactions. We have demonstrated that RSV-DF polymeric micelles retain the cytotoxic and metabolic effects of RSV on A549 cancer cells with potencies similar to that of the free compound...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28008233/folic-acid-conjugated-amphiphilic-alternating-copolymer-as-a-new-active-tumor-targeting-drug-delivery-platform
#13
Xia Li, Myron R Szewczuk, Cecile Malardier-Jugroot
Targeted drug delivery using polymeric nanostructures is an emerging cancer research area, engineered for safer, more efficient, and effective use of chemotherapeutic drugs. A pH-responsive, active targeting delivery system was designed using folic acid functionalized amphiphilic alternating copolymer poly(styrene-alt-maleic anhydride) (FA-DABA-SMA) via a biodegradable linker 2,4-diaminobutyric acid (DABA). The polymeric template is pH responsive, forming amphiphilic nanostructures at pH 7, allowing the encapsulation of hydrophobic drugs on its interior...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27998415/-effects-of-both-folic-acid-p16-protein-expression-and-their-interaction-on-progression-of-cervical-cancerization
#14
W L Jia, L Ding, Z Y Ren, T T Wu, W M Zhao, S L Fan, J T Wang
Objective: To explore the effects of both folic acid, p16 protein expression and their interaction on progression of cervical cancerization. Methods: Participants were pathologically diagnosed new cases, including 80 women with normal cervical (NC), 55 patients with low-grade cervical intraepithelial neoplasia (CINⅠ), 55 patients with high-grade cervical intraepithelial neoplasia (CINⅡ/Ⅲ) and 64 patients with cervical squamous cell carcinoma (SCC). Serum folate levels were detected by microbiological assay method while p16 protein expression levels were measured by Western-blot...
December 10, 2016: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/27959453/a-novel-therapy-for-ovarian-cancer-using-real%C3%A2-time-imaging
#15
Zhen Zhang, Zhaojie Chen, Beibei Xie, Haiyan Zhang
The present study was designed to develop an activable, dual‑targeted theranostic platform combining fluorescent and cytotoxic templates to provide a novel strategy for specific drug delivery and cellular imaging in ovarian cancer cells. Two compounds of a folic acid‑prodrug‑doxorubicin (Dox) scaffold were synthesized, and their antiproliferative activities were evaluated using 3‑(4,5‑dimethylthiazol‑2‑yl)‑2,5‑diphenyltetrazolium bromide and flow cytometric analysis. The process of drug release was investigated using fluorescence emission spectra assay and confocal laser scanning microscopy...
January 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27934479/doxorubicin-and-sirna-codelivery-via-chitosan-coated-ph-responsive-mixed-micellar-polyplexes-for-enhanced-cancer-therapy-in-multidrug-resistant-tumors
#16
Adeel Masood Butt, Mohd Cairul Iqbal Mohd Amin, Haliza Katas, Nor Azian Abdul Murad, Rahman Jamal, Prashant Kesharwani
This study investigated the potential of chitosan-coated mixed micellar nanocarriers (polyplexes) for codelivery of siRNA and doxorubicin (DOX). DOX-loaded mixed micelles (serving as cores) were prepared by thin film hydration method and coated with chitosan (CS, serving as outer shell), and complexed with multidrug resistance (MDR) inhibiting siRNA. Selective targeting was achieved by folic acid conjugation. The polyplexes showed pH-responsive enhanced DOX release in acidic tumor pH, resulting in higher intracellular accumulation, which was further augmented by downregulation of mdr-1 gene after treatment with siRNA-complexed polyplexes...
December 5, 2016: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/27933980/nanoceria-mediated-drug-delivery-for-targeted-photodynamic-therapy-on-drug-resistant-breast-cancer
#17
Hong Li, Cong Liu, Yi-Ping Zeng, Yu-Hui Hao, Jia-Wei Huang, Zhang-You Yang, Rong Li
Photodynamic therapy (PDT) has shown great potential for overcoming drug-resistant cancers. Here, we report a multifunctional drug delivery system based on chlorin e6 (Ce6)/folic acid (FA)-loaded branched polyethylenimine-PEGylation ceria nanoparticles (PPCNPs-Ce6/FA), which was developed for targeted PDT to overcome drug-resistant breast cancers. Nanocarrier delivery and FA targeting significantly promoted the cellular uptake of photosensitizers (PSs), followed by their accumulation in lysosomes. PPCNPs-Ce6/FA generated reactive oxygen species (ROS) after near-infrared irradiation (NIR, 660 nm), leading to reduced P-glycoprotein (P-gp) expression, lysosomal membrane permeabilization (LMP), and excellent phototoxicity toward resistant MCF-7/ADR cells, even at ultralow doses...
November 23, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27933825/plasmon-enhanced-photodynamic-cancer-therapy-by-upconversion-nanoparticles-conjugated-with-au-nanorods
#18
Chieh-Wei Chen, Yung-Chieh Chan, Michael Hsiao, Ru-Shi Liu
Photodynamic therapy (PDT) based on photosensitizers (PSs) constructed with nanomaterials has been widely applied to treat cancer. This therapy is characterized by an improved PS accumulation in tumor regions. However, challenges, such as short penetration depth of light and low extinction coefficient of PSs, limit PDT applications. In this study, a nanocomposite consisting of NaYF4:Yb/Er upconversion nanoparticles (UCPs) conjugated with gold nanorods (Au NRs) was developed to improve the therapeutic efficiency of PDT...
November 30, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27926514/novel-amphiphilic-folic-acid-cholesterol-chitosan-micelles-for-paclitaxel-delivery
#19
Li-Chun Cheng, Yan Jiang, Yu Xie, Lu-Lu Qiu, Qing Yang, Hui-Yi Lu
In order to decrease the toxicity of paclitaxel (PTX) and increase the efficiency, we developed an amphiphilic PTX injection system using a biodegradable and biocompatible polymer synthesized by folic acid, cholesterol, and chitosan (FACC). This FACC-based polymer had a low critical concentration (64.13μg/ml) and could self-assemble in aqueous condition to form nanoscale micelles. The particle sizes of FACC-PTX micelles were 253.2±0.56 nm, the encapsulation efficiency and loading capacity of these FACC-PTX micelles were 65...
December 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27923144/folic-acid-grafted-bovine-serum-albumin-decorated-graphene-oxide-an-efficient-drug-carrier-for-targeted-cancer-therapy
#20
Naxin Ma, Jing Liu, Wenxiu He, Zhonghao Li, Yuxia Luan, Yunmei Song, Sanjay Garg
Targeting drug carrier systems based on graphene oxide (GO) are of great interest, since it can selectively deliver anticancer drugs to tumor cells, and enhance therapeutic activities with minimized side effects. However, direct grafting target molecules on GO usually results in aggregation of physiological fluid, limiting its biomedical applications. Here, we propose a new strategy to construct targeting GO drug carrier using folic acid grafted bovine serum albumin (FA-BSA) as both the stabilizer and targeting agent...
November 29, 2016: Journal of Colloid and Interface Science
keyword
keyword
93069
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"