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https://www.readbyqxmd.com/read/29140684/janus-gold-nanoplatform-for-synergetic-chemoradiotherapy-and-computed-tomography-imaging-of-hepatocellular-carcinoma
#1
Zheng Wang, Dan Shao, Zhimin Chang, Mengmeng Lu, Yingshuai Wang, Juan Yue, Dian Yang, Mingqiang Li, Qiaobing Xu, Wen-Fei Dong
There is a pressing need to develop nanoplatforms that integrate multimodal therapeutics to improve treatment responses and prolong the survival of patients with unresectable hepatocellular carcinoma (HCC). Mesoporous silica-coated gold nanomaterials have emerged as a novel multifunctional platform combining tunable surface plasmon resonance and mesoporous properties that exhibit multimodality properties in cancer theranostics. However, their reduced radiation-absorption efficiency and limited surface area hinder their further radiochemotherapeutic applications...
November 17, 2017: ACS Nano
https://www.readbyqxmd.com/read/29135959/intratumoral-delivery-of-doxorubicin-on-folate-conjugated-graphene-oxide-by-in-situ-forming-thermo-sensitive-hydrogel-for-breast-cancer-therapy
#2
Yi Teng Fong, Chih-Hao Chen, Jyh-Ping Chen
By taking advantage of the pH-sensitive drug release property of graphene oxide (GO) after intracellular uptake, we prepared folic acid (FA)-conjugated GO (GOFA) for targeted delivery of the chemotherapeutic drug doxorubicin (DOX). GOFA-DOX was further encapsulated in an injectable in-situ forming thermo-sensitive hyaluronic acid-chitosan-g-poly(N-isopropylacrylamide) (HACPN) hydrogel for intratumoral delivery of DOX. As the degradation time of HACPN could be extended up to 3 weeks, intratumoral delivery of GOFA-DOX/HACPN could provide controlled and targeted delivery of DOX through slow degradation HACPN and subsequent cellular uptake of released GOFA-DOX by tumor cells through interactions of GOFA with folate receptors on the tumor cell's surface...
November 14, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29132834/folic-acid-intake-and-folate-status-and-colorectal-cancer-risk-a%C3%A2-systematic-review-and-meta-analysis
#3
Sara Moazzen, Roya Dolatkhah, Jafar Sadegh Tabrizi, Jabraeel Shaarbafi, Behrooz Z Alizadeh, Geertruida H de Bock, Saeed Dastgiri
BACKGROUND & AIMS: To evaluate the controversies among the studies assessing the association between folic acid intake or folate status and colorectal cancer risk. METHODS: PubMed, Cochrane library and references of related articles were searched from January 2000 to September 2016. Studies on folic acid intake or folate status and colorectal cancer or adenoma risk were included. Full text review was conducted for potentially eligible studies. Quality assessment was performed...
October 28, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29124936/in-vivo-ct-photoacoustic-imaging-and-nir-triggered-chemo-photothermal-combined-therapy-based-on-a-gold-nanostar-mesoporous-silica-and-thermo-sensitive-liposomes-composited-nanoprobe
#4
Jie An, Xiao-Quan Yang, Kai Cheng, Xian-Lin Song, Lin Zhang, Cheng Li, Xiao-Shuai Zhang, Yang Xuan, Yuan-Yang Song, Bi-Yun Fang, Xiao-Lin Hou, Yuan-Di Zhao, Bo Liu
Safe multifunctional nanoplatforms that have multiple therapeutic functions integrated with imaging capabilities are highly desired for biomedical applications. In this paper, targeted chemo-photothermal synergistic therapy and photoacoustic/CT imaging of tumor were achieved by one novel multifunctional nanoprobe (GMS/DOX@SLB-FA), it was composed of gold nanostar core and doxorubicin (DOX) loading mesoporous silica shell (GMS), which was coated with folic acid (FA) modified thermosensitively supported lipid bilayer (FA-SLB) as gatekeeper...
November 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29123391/surface-enhanced-raman-scattering-investigation-of-targeted-delivery-and-controlled-release-of-gemcitabine
#5
Ty Santiago, Rebecca Sinnott DeVaux, Katarzyna Kurzatkowska, Ricardo Espinal, Jason I Herschkowitz, Maria Hepel
Advanced and metastatic cancer forms are extremely difficult to treat and require high doses of chemotherapeutics, inadvertently affecting also healthy cells. As a result, the observed survival rates are very low. For instance, gemcitabine (GEM), one of the most effective chemotherapeutic drugs used for the treatment of breast and pancreatic cancers, sees only a 20% efficacy in penetrating cancer tissue, resulting in <5% survival rate in pancreatic cancer. Here, we present a method for delivering the drug that offers mitigation of side effects, as well as a targeted delivery and controlled release of the drug, improving its overall efficacy...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29110284/folate-conjugated-hybrid-nanocarrier-for-targeted-letrozole-delivery-in-breast-cancer-treatment
#6
Abbas Hemati Azandaryani, Soheila Kashanian, Katayoun Derakhshandeh
PURPOSE: Letrozole as a steroidal anticancer drug with hydrophobic nature is usually administrated by oral route for patient treatment and the injectable formulation for this drug has not still been reported. In this study, a new letrozole incorporated folate-conjugated polymer - lipid hybrid nanoparticles - is introduced for cancer treatment. METHODS: Nanoparticles were fabricated via modified oil in water ionic gelation method using optimization parameters and then were coupled to folic acid using carbodiimide activation...
November 6, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/29104951/folate-peg-conjugates-of-a-far-red-light-activatable-paclitaxel-prodrug-to-improve-selectivity-toward-folate-receptor-positive-cancer-cells
#7
Pritam Thapa, Mengjie Li, Radha Karki, Moses Bio, Pallavi Rajaputra, Gregory Nkepang, Sukyung Woo, Youngjae You
We recently demonstrated the far-red light-activatable prodrug of paclitaxel (PTX), Pc-(L-PTX)2. Upon illumination with a 690 nm laser, Pc-(L-PTX)2 showed combinational cell killing from rapid photodynamic therapy damage by singlet oxygen, followed by sustained chemotherapy effects from locally released PTX. However, its high lipophilicity (log D7.4 > 3.1) caused aggregation in aqueous solutions and has nonselectivity toward cancer cells. To solve these important problems, we prepared folic acid (FA)-conjugated and photoactivatable prodrugs of PTX with a polyethylene glycol (PEG) spacer of various chain lengths: FA-PEG n -Pc-L-PTX [n = 0 (0k, 5), ∼23 (1k, 7a), ∼45 (2k, 7b), ∼80 (3...
October 31, 2017: ACS Omega
https://www.readbyqxmd.com/read/29104818/design-and-synthesis-of-new-sulfur-containing-hyperbranched-polymer-and-theranostic-nanomaterials-for-bimodal-imaging-and-treatment-of-cancer
#8
Blaze Heckert, Tuhina Banerjee, Shoukath Sulthana, Shuguftha Naz, Riyadh Alnasser, Deaven Thompson, Guillaume Normand, Jan Grimm, J Manuel Perez, Santimukul Santra
In this study, we have synthesized a new hyperbranched polyester polymer containing sulfur-pendants (HBPE-S) in the branching points. This HBPE-S polymer is composed of spherical shaped, aliphatic three-dimensional architecture with carboxylic acid groups on the surface. The presence of sulfur pendants in the polymeric cavities demonstrated important role in the effective encapsulation of Bi-DOTA complexes ([Bi] = 5.21 μM), when compared to the previously reported polymer without sulfur pendants (HBPE, [Bi] = 1...
March 21, 2017: ACS Macro Letters
https://www.readbyqxmd.com/read/29082408/facile-synthesis-of-highly-biocompatible-folic-acid-functionalised-sio2-nanoparticles-encapsulating-rare-earth-metal-complexes-and-their-application-in-targeted-drug-delivery
#9
Xiuling Xu, Fan Hu, Qi Shuai
Mesoporous silica core-shell nanospheres encapsulating a rare-earth metal complex (RC) were first synthesised through a facile W/O (water in oil) inverse microemulsion method. In order to achieve targeted complex delivery, folic acid (FA) was used as the targeting component due to its high affinity for over-expressed folate receptors (FRs) in cancer cells. The RC2@SiO2-FA nanospheres were characterised via ultraviolet-visible light absorption spectroscopy (UV-vis spectroscopy), dynamic light scattering (DLS), scanning electron microscopy (SEM) and transmission electron microscopy (TEM)...
November 14, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29075112/effect-of-inhibitors-of-endocytosis-and-nf-kb-signal-pathway-on-folate-conjugated-nanoparticle-endocytosis-by-rat-kupffer-cells
#10
Hongbo Tang, Hongli Chen, Yajing Jia, Xiaoyan Liu, Zhaohong Han, Aihua Wang, Qi Liu, Xinlei Li, Xin Feng
The regular accumulation of nanoparticles in the liver makes them hepatotoxic and decreases the circulation time, thus reducing their therapeutic effect. Resolving this problem will be significant in improving bioavailability and reducing side effects. In this study, we reduced the phagocytosis of epirubicin (EPI)-loaded folic acid-conjugated pullulan acetate (FPA/EPI) nanoparticles by Kupffer cells (KCs) through internalization and nuclear factor kappa B (NF-kB) signal pathway inhibitors, thus allowing development of FPA/EPI nanoparticles as a nanodrug delivery system (NDDS) based on our previous study...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29070520/folic-acid-inhibits-nasopharyngeal-cancer-cell-proliferation-and-invasion-via-activation-of-fr%C3%AE-erk1-2-tslc1-pathway
#11
Zhibiao Liu, Xin Jin, Wen Pi, Shouhou Liu
Folic acid (FA), which is necessary for normal cell division of mammals, has been implicated to be involved in many tumors. Dietary FA intake has been reported to be associated with a lower risk of nasopharyngeal cancer ( NPC). However, the molecular mechanisms of FA in NPC cells remain unclear. In this study, we found that FA treatment dose-dependently inhibited the proliferation, invasion and migration of NPC cells, via folate receptor alpha (FRα). We further found that FA, bounding to FRα, induced the activation of MEK/ERK1/2, and increased the expressions of TSLC1 and E-cadherin...
October 25, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29035716/synthesis-photophysical-and-cellular-characterisation-of-folate-and-methotrexate-labelled-luminescent-lanthanide-complexes
#12
Zhangli Du, Jing Sun, Christie A Bader, Doug A Brooks, Minqi Li, Xun Li, Sally E Plush
In this work we have developed a series of highly emissive europium(III) and terbium(III) complexes tethered to either folic acid (FA) or methotrexate (MTX), with the aim of developing visual probes that enable the imaging of folate receptors in cancer cells. The synthesis, photophysical properties and cellular behaviour are reported for four new lanthanide Ln(III) complexes, where either FA or MTX are tethered to 1,4,7-tris(carbonylmethyl)-10-(4'-quinolineacetic acid, (7'-acetamido)-1',2'-dihydro-2'-oxo)-1,4,7,10-tetraazacyclododecane Ln(III) complex, and Ln(III)=Eu(III) or Tb(III); herein referred to as Eu-FA, Eu-MTX, Tb-FA or Tb-MTX...
October 10, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29032208/chitosan-based-nano-formulation-enhanced-the-anticancer-efficacy-of-hesperetin
#13
Lizha Mary, Balaji Sadhasivam, Kanagaraj Palaniyandi, Thangavel Muthuswamy, Ilangovan Ramachandran, Anandhan Balakrishnan, Surajit Pathak, Shoba Narayan, Satish Ramalingam
Cancer is one of the major causes of increased morbidity and mortality in modern society. Colorectal cancer is the third leading cause for cancer related death worldwide. Current chemotherapeutics are not very effective and have severe side effects. Hesperetin is a bioflavonoid from citrus fruits and its clinical use is restricted because of the poor water solubility. Folate receptor is over expressed in various cancer cells. In this regard, we have synthesized the Chitosan Folate Hesperetin nanoparticle (CFH) by covalently conjugating folic acid with chitosan molecules...
October 12, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29027828/folate-decorated-and-nir-activated-nanoparticles-based-on-platinum-iv-prodrugs-for-targeted-therapy-of-ovarian-cancer
#14
Yu Sun, Tian-Yi Shi, Ling-Yun Zhou, Yu-Yan Zhou, Bai-Wang Sun, Xiao-Ping Liu
Platinum-based drugs are used to treat a variety of cancers but have many side effects such as nephrotoxicity and neurotoxicity. A folate-decorated nanoparticles system with a good drug payload can selectively deliver drugs into folate receptor (FR)-overexpressing cancer cells to prevent the shortcomings of platinum-based chemotherapy. Here, folate-decorated and near-infrared (NIR) laser-activated nanoparticles (abbreviated as Pt(IV)-FINPs) were prepared via ultrasonic self-assembling of platinum(IV) prodrug c,c,t-Pt(NH3)2Cl2(OOCCH2CH2COOH)2, folic acid (FA)-functionalized lipid DSPE-PEG-FA and NIR fluorescent dye indocyanine green (ICG)...
October 13, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29025636/folic-acid-grafted-and-tertiary-amino-based-ph-responsive-pentablock-polymeric-micelles-for-targeting-anticancer-drug-delivery
#15
Quan Chen, Jiewei Zheng, Xiaozhe Yuan, Jufang Wang, Lijuan Zhang
Increasing target to tumor sites and reducing accumulation at normal tissue sites of anticancer drugs are essential to improve the cancer chemotherapy efficiency. In this study, we have developed a novel pentablock polymeric poly(ethylene glycol)-b-(poly(2-(diethylamino) ethyl methacrylate)-b-poly (hydroxyethyl methacrylate)-g-folic acid)2 [PEG-b-(PDEAEMA-b-PHEMA-g-FA)2] micelles as anticancer drug nanocarrier. The carriers could target tumor cells rapidly, and response to the tumor sites pH to control drug release...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29018855/mitochondrial-targeted-multifunctional-mesoporous-au-pt-nanoparticles-for-dual-mode-photodynamic-and-photothermal-therapy-of-cancers
#16
Yang Song, Qiurong Shi, Chengzhou Zhu, Yanan Luo, Qian Lu, He Li, Ranfeng Ye, Dan Du, Yuehe Lin
In the conventional non-invasive cancer treatments, such as photodynamic therapy (PDT) and photothermal therapy (PTT), light irradiation is precisely focused on tumors to induce apoptosis via the generation of reactive oxygen species (ROS) or localized heating. However, overconsumption of oxygen and restricted diffusion distance of ROS limit the therapeutic effects on hypoxic tumors. Herein, we developed a platform for the rapid uptake of multifunctionalized Au@Pt nanoparticles (NPs) by mitochondria in cancer cells...
October 26, 2017: Nanoscale
https://www.readbyqxmd.com/read/28994432/an-intelligent-nir-responsive-chelate-copper-based-anticancer-nanoplatform-for-synergistic-tumor-targeted-chemo-phototherapy
#17
Qianhua Feng, Wanxia Zhang, Yuzhen Li, Xuemei Yang, Yongwei Hao, Hongling Zhang, Wei Li, Lin Hou, Zhenzhong Zhang
The chelate copper-based anticancer drug bleomycin (BLM) is usually believed to bind metal ions especially Cu(ii) to generate the "activated BLM" for DNA cleavage. Herein, BLM and L-menthol (LM) co-loaded hollow mesoporous Cu2-xS nanoparticles (HMCu2-xS NPs) with surface folic acid (FA) modification were formulated to construct an intelligent NIR-responsive nanoplatform for synergistic tumor targeted chemo-phototherapy. With the tumor targeting ability of the folate receptor (FR)-positive, FA-HMCu2-xS/BLM/LM could pinpoint tumor cells efficiently...
October 19, 2017: Nanoscale
https://www.readbyqxmd.com/read/28994425/targeting-ligand-functionalized-photothermal-scaffolds-for-cancer-cell-capture-and-in-situ-ablation
#18
Jing Zhang, Jingchao Li, Xiuhui Wang, Naoki Kawazoe, Guoping Chen
Scaffolds have been explored as a useful carrier to deliver efficient photothermal conversion agents for localized photothermal therapy applications because they can confine the agents in designated regions. However, cell capture by porous structures cannot discriminate between cancer cells and normal cells. In this study, folic acid (FA) as a typical targeting ligand for cancer cells was introduced into the porous photothermal scaffolds. Poly-l-lysine was mixed with gelatin to increase the amino side groups for FA incorporation...
October 24, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28994325/folic-acid-conjugated-peg-coated-gold-iron-oxide-core-shell-nanocomplex-as-a-potential-agent-for-targeted-photothermal-therapy-of-cancer
#19
Habib Ghaznavi, Samira Hosseini-Nami, S Kamran Kamrava, Rasoul Irajirad, Shayan Maleki, Ali Shakeri-Zadeh, Alireza Montazerabadi
This study reports the synthesis and characterization of poly(ethylene glycol) coated gold@iron oxide core-shell nanoparticles conjugated with folic acid (FA-PEG-Au@IONP). Also, targeted therapeutic properties of such a nanocomplex were studied on human nasopharyngeal carcinoma cell line KB and human breast adenocarcinoma cell line MCF-7 in vitro. The synthesized nanocomplex was characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS), UV-Vis spectroscopy, vibrating sample magnetometry (VSM), and Fourier transform infrared (FTIR) spectroscopy...
October 10, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28993980/characterization-cytotoxicity-and-genotoxicity-of-tio2-and-folate-coupled-chitosan-nanoparticles-loading-polyprenol-based-nanoemulsion
#20
Ran Tao, Chengzhang Wang, Changwei Zhang, WenJun Li, Hao Zhou, Hongxia Chen, Jianzhong Ye
The structure and bioactivity of Ginkgo biloba leaves polyprenol (GBP) are similar to that of dolichol which widely exists in human and mammalian organs. GBP possesses potential pharmacological activities against cancer. This study involved oil-in-water type nanoemulsion (NE) loading GBP was prepared by dissolving polyprenol in nanoemulsion of sodium tripolyphosphate (TPP)/TiO2 solution, Triton X-100, and 1-octanol by inversed-phase emulsification (EIP) and ultrasonic emulsification (UE) method. Folic acid (FA)-coupled chitosan (CS) nanoparticles (NPs), GBP-FA-CS-NPs and GBP-TiO2-FA-CS-NPs, were fabricated by ionic cross-linking of positively charged FA-CS conjugates and negatively charged nanoemulsion with TPP/TiO2...
October 9, 2017: Biological Trace Element Research
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