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https://www.readbyqxmd.com/read/29154402/transvaginal-ultrasound-tvs-versus-magnetic-resonance-mr-for-diagnosing-deep-infiltrating-endometriosis-a-systematic-review-and-meta-analysis
#1
REVIEW
S Guerriero, L Saba, M A Pascual, S Ajossa, I Rodriguez, V Mais, J L Alcazar
OBJECTIVES: To perform a systematic review of studies comparing the diagnostic accuracy of TVS and MRI in Deep Infiltrating Endometriosis (DIE) including only studies in which patients have been underwent both techniques. METHODS: An extensive search of papers comparing TVS and MRI in DIE was performed in Medline (Pubmed) and Web of Sciences from January 1989 to January 2016. Studies were considered eligible if they reported on the use of TVS and MRI in the same set of patients for the preoperative detection of endometriosis in pelvic locations in women with clinical suspicion of DIE using the surgical data as a reference standard...
November 20, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29111855/neuroprotective-effects-of-inhibitors-of-acid-sensing-ion-channels-asics-in-optic-nerve-crush-model-in-rodents
#2
Dorota L Stankowska, Brett H Mueller, Hidehiro Oku, Tsunehiko Ikeda, Adnan Dibas
PURPOSE: The purpose of the current study was to assess the potential involvement of acid-sensing ion channel 1 (ASIC1) in retinal ganglion cell (RGC) death and investigate the neuroprotective effects of inhibitors of ASICs in promoting RGC survival following optic nerve crush (ONC). RESULTS: ASIC1 protein was significantly increased in optic nerve extracts at day 7 following ONC in rats. Activated calpain-1 increased at 2 and 7 days following ONC as evidenced by increased degradation of α-fodrin, known substrate of calpain...
November 7, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29069858/hepatocellular-carcinoma-in-hemodialysis-patients
#3
Chern-Horng Lee, Sen-Yung Hsieh, Chih-Chun Chang, I-Kuan Wang, Wen-Hung Huang, Cheng-Hao Weng, Ching-Wei Hsu, Tzung-Hai Yen
We investigated the rates and predictors of mortality in hepatocellular carcinoma (HCC) patients who were or were not undergoing long-term hemodialysis. The participants in this retrospective observational study were 1298 HCC patients (60.0 ± 12.1 years old, 72% male), of whom 172 were undergoing hemodialysis and 1126 were not. HCC patients on hemodialysis exhibited a higher hepatitis C virus carrier rate (49.4% versus 39.3%, P = 0.012), lower hepatitis B virus carrier rate (37.2% versus 58.3%, P < 0.001) and lower hepatitis B or C virus carrier rate (77...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29063358/geographic-distribution-and-incidence-of-lyme-borreliosis-in-the-west-of-ireland
#4
A Vellinga, H Kilkelly, J Cullinan, B Hanahoe, M Cormican
BACKGROUND: Lyme borreliosis is caused by Borrelia burgdorferi and is the most common tick-transmitted infection in temperate regions. Infection often presents with erythema migrans and/or other clinical features in early infection. METHODS: Blood samples are submitted for testing for antibodies to Borrelia burgdorferi by enzyme immunoassay and positive samples are confirmed by a reference laboratory by IgG and IgM line immune assay. A retrospective extraction of all laboratory requests and results for Lyme borreliosis from 2011 to 2014 was performed...
October 23, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29046934/-knowledge-of-the-population-about-leading-symptoms-of-cardiovascular-emergencies-and-the-responsibility-and-accessibility-of-medical-facilities-in-emergencies-results-of-the-kzen-study-in-western-palatinate
#5
T Luiz, S Dittrich, G Pollach, C Madler
BACKGROUND: The Westpfalz is a mainly rural region in the southwestern part of the German state of Rhineland-Palatinate with 527,000 inhabitants and demonstrates a higher than average cardiovascular mortality compared to the rest of Germany. The reasons are not known. Our study attempted to investigate whether significant deficits in knowledge of the population on cardiovascular emergencies, the accessibility of emergency medical services (EMS) or the different responsibilities and abilities of the medical facilities could be held responsible for this...
November 2017: Der Anaesthesist
https://www.readbyqxmd.com/read/29031170/a-dose-escalation-study-of-bi-daily-once-weekly-oral-docetaxel-either-as-modradoc001-or-modradoc006-combined-with-ritonavir
#6
Vincent A de Weger, Frederik E Stuurman, Jeroen J M A Hendrikx, Johannes J Moes, Emilia Sawicki, Alwin D R Huitema, Bastiaan Nuijen, Bas Thijssen, Hilde Rosing, Marianne Keessen, Marja Mergui-Roelvink, Jos H Beijnen, Jan H M Schellens, Serena Marchetti
INTRODUCTION: Two solid dispersions of docetaxel (denoted ModraDoc001 capsule and ModraDoc006 tablet (both 10 mg)) were co-administered with 100 mg ritonavir (/r) and investigated in a bi-daily once weekly (BIDW) schedule. Safety, maximum tolerated dose (MTD), pharmacokinetics (PK) and preliminary activity were explored. METHODS: Adult patients with metastatic solid tumours were included in two dose-escalation arms. PK sampling was performed during the first week and the second or third week...
October 11, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28986112/seagrass-leaf-element-content-a-global-overview
#7
J Arie Vonk, Fee O H Smulders, Marjolijn J A Christianen, Laura L Govers
Knowledge on the role of seagrass leaf elements and in particular micronutrients and their ranges is limited. We present a global database, consisting of 1126 unique leaf values for ten elements, obtained from literature and unpublished data, spanning 25 different seagrass species from 28 countries. The overall order of average element values in seagrass leaves was Na>K>Ca>Mg>S>Fe>Al>Si>Mn>Zn. Although we observed differences in leaf element content between seagrass families, high intraspecific variation indicated that leaf element content was more strongly determined by environmental factors than by evolutionary history...
October 3, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28958851/effects-of-liraglutide-on-weight-satiation-and-gastric-functions-in-obesity-a-randomised-placebo-controlled-pilot-trial
#8
Houssam Halawi, Disha Khemani, Deborah Eckert, Jessica O'Neill, Hoda Kadouh, Karen Grothe, Matthew M Clark, Duane D Burton, Adrian Vella, Andres Acosta, Alan R Zinsmeister, Michael Camilleri
BACKGROUND: Liraglutide, a long-acting GLP-1 receptor agonist, is approved for treatment of obesity; however, the mechanisms of action of liraglutide are incompletely understood. We compared effects of liraglutide versus placebo on gastric motor functions, satiation, satiety, and weight in obese individuals over 16 weeks. METHODS: We did a randomised, double-blind, placebo-controlled pilot trial at a single centre (Mayo Clinic, Rochester, MN, USA). Participants were randomly allocated (1:1) by a computer generated randomisation schedule with no stratification to receive subcutaneous liraglutide (3·0 mg) or placebo, with standardised nutritional and behavioural counselling...
September 25, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28949694/equilibration-dynamics-of-strongly-interacting-bosons-in-2d-lattices-with-disorder
#9
Mi Yan, Hoi-Yin Hui, Marcos Rigol, V W Scarola
Motivated by recent optical lattice experiments [J.-y. Choi et al., Science 352, 1547 (2016)SCIEAS0036-807510.1126/science.aaf8834], we study the dynamics of strongly interacting bosons in the presence of disorder in two dimensions. We show that Gutzwiller mean-field theory (GMFT) captures the main experimental observations, which are a result of the competition between disorder and interactions. Our findings highlight the difficulty in distinguishing glassy dynamics, which can be captured by GMFT, and many-body localization, which cannot be captured by GMFT, and indicate the need for further experimental studies of this system...
August 18, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28949627/determination-of-the-density-and-temperature-dependence-of-the-shear-viscosity-of-a-unitary-fermi-gas-based-on-hydrodynamic-flow
#10
Marcus Bluhm, Jiaxun Hou, Thomas Schäfer
We determine the shear viscosity of the ultracold Fermi gas at unitarity in the normal phase using hydrodynamic expansion data. The analysis is based on a generalized fluid dynamic framework which ensures a smooth transition between the fluid dynamic core of the cloud and the ballistic corona. We use expansion data taken by Joseph, Elliott, and Thomas [Shear Viscosity of a Universal Fermi Gas Near the Superfluid Phase Transition, Phys. Rev. Lett. 115, 020401 (2015).PRLTAO0031-900710.1103/PhysRevLett.115.020401] and measurements of the equation of state by Ku et al...
August 11, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28947664/polycomb-complexes-in-x-chromosome-inactivation
#11
REVIEW
Neil Brockdorff
Identifying the critical RNA binding proteins (RBPs) that elicit Xist mediated silencing has been a key goal in X inactivation research. Early studies implicated the Polycomb proteins, a family of factors linked to one of two major multiprotein complexes, PRC1 and PRC2 (Wang 2001 Nat. Genet.28, 371-375 (doi:10.1038/ng574); Silva 2003 Dev. Cell4, 481-495 (doi:10.1016/S1534-5807(03)00068-6); de Napoles 2004 Dev. Cell7, 663-676 (doi:10.1016/j.devcel.2004.10.005); Plath 2003 Science300, 131-135 (doi:10.1126/science...
November 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28926329/postoperative-haematocrit-and-outcome-in-critically-ill-surgical-patients
#12
Ana Martins Lopes, Diana Silva, Gabriela Sousa, Joana Silva, Alice Santos, Fernando José Abelha
INTRODUCTION: Haematocrit has been studied as an outcome predictor. The aim of this study was to evaluate the correlation between low haematocrit at surgical intensive care unit admission and high disease scoring system score and early outcomes. MATERIAL AND METHODS: This retrospective study included 4398 patients admitted to the surgical intensive care unit between January 2006 and July 2013. Acute physiology and chronic health evaluation and simplified acute physiology score II values were calculated and all variables entered as parameters were evaluated independently...
August 31, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28884426/thyroid-autoimmune-antibodies-in-patients-with-papillary-thyroid-carcinoma-a-double-edged-sword
#13
Chen-Tian Shen, Xin-Yun Zhang, Zhong-Ling Qiu, Zhen-Kui Sun, Wei-Jun Wei, Hong-Jun Song, Quan-Yong Luo
PURPOSE: The relationship between thyroid autoimmunity and thyroid cancer remains controversial. The objective of this study is to comprehensively analyze the association between thyroid autoimmune antibodies and disease statuses of papillary thyroid carcinoma (PTC). METHODS: Patients were divided into different groups according to their final diagnoses after radioiodine therapy as well as their serum anti-thyroglobulin antibody (TgAb) and anti-thyroidperoxidase antibody (TPOAb) titers...
October 2017: Endocrine
https://www.readbyqxmd.com/read/28818651/genomic-characterization-of-a-paediatric-mrsa-outbreak-by-next-generation-sequencing
#14
E Ugolotti, E Di Marco, R Bandettini, R Biassoni
INTRODUCTION: Twelve strains of meticillin-resistant Staphylococcus aureus (MRSA) isolated during a suspected outbreak in a paediatric intensive care unit were analysed by whole-genome sequencing (WGS). AIM: To define the clonality of MRSA strains to a high discriminative power, and to evaluate the presence of genetic determinants responsible for antibiotic resistance and virulence. RESULTS: Ten out of 12 strains belonged to multi-locus sequence type ST2625, while the other two strains were ST8...
August 14, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28812372/factors-associated-with-depression-detection-in-a-new-hampshire-mental-health-outreach-program
#15
Angela R Ghesquiere, Renee Pepin, Jennifer Kinsey, Stephen J Bartels, Martha L Bruce
OBJECTIVES: For mental health outreach programs for older adults, accurately detecting depression is key to quality service provision. Multiple factors, including gender, cognitive impairment, or recent bereavement may affect depression detection, but this is under-studied. Therefore, we sought to both establish rates of depressive symptom detection and to examine factors associated with inaccuracies of detecting depression among participants in a mental health outreach program serving older adults...
August 16, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28811159/implementing-and-scaling-up-hcv-treatment-services-for-people-who-inject-drugs-and-other-high-risk-groups-in-ukraine-an-evaluation-of-programmatic-and-treatment-outcomes
#16
Alyona Mazhnaya, Anna Meteliuk, Tetiana Barnard, Alexei Zelenev, Sergii Filippovych, Frederick L Altice
BACKGROUND: HCV prevalence estimates among people who inject drugs (PWID) in Ukraine is high (60-90%), yet barriers to HCV treatment and care remain substantial including limited access to direct acting antiviral (DAA) medications. A feasibility scale-up project implemented HCV treatment in community-based settings to improve access to DAA treatment for key populations in this context. METHODS: Using program-level data and verified medical records, we describe the development, implementation processes and outcomes for HCV treatment for PWID and other risks groups...
September 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28772347/diffusion-kurtosis-imaging-in-identifying-the-malignancy-of-lymph-node-during-the-primary-staging-of-rectal-cancer
#17
Jing Yu, Xin Dai, Hai-Hua Zou, Jia-Cheng Song, Yan Li, Hai-Bin Shi, Qing Xu, Hongbing Shen
AIM: To assess the diagnostic value of diffusion kurtosis imaging (DKI) for discriminating between benign and malignant lymph nodes (LNs) in patients with rectal carcinoma. METHOD: Eighty-five patients with rectal adenocarcinoma who underwent total mesorectal excision of the rectum were studied. A total of 273 lymph nodes were harvested and subjected to histological analysis.. Quantitative parameters (apparent diffusion parameter of Gaussian distribution (Dapp ), apparent kurtosis coefficient (Kapp ) and apparent diffusion coefficient (ADC)) of lymph node were derived from DKI...
August 3, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28766287/single-molecule-analysis-of-pre-mrna-splicing-with-colocalization-single-molecule-spectroscopy-cosmos
#18
Joerg E Braun, Victor Serebrov
Recent development of single-molecule techniques to study pre-mRNA splicing has provided insights into the dynamic nature of the spliceosome. Colocalization single-molecule spectroscopy (CoSMoS) allows following spliceosome assembly in real time at single-molecule resolution in the full complexity of cellular extracts. A detailed protocol of CoSMoS has been published previously (Anderson and Hoskins, Methods Mol Biol 1126:217-241, 2014). Here, we provide an update on the technical advances since the first CoSMoS studies including slide surface treatment, data processing, and representation...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28758579/perspectives-of-medieval-persian-medicine-on-multiple-sclerosis
#19
Mohammad Ali Sahraian, Mohsen Parviz, Behnam Sheibani, Nicoline Schiess, Zahra Ghorbanifar, Mohammad Kamalinejad, Esmail Nazem, Omid Sadeghpour, Hossein Rezaeizadeh
INTRODUCTION: Traditional Persian Medicine (TPM) was the prevailing practice of medicine in the Eurasia region up through the 18th century, a practice of medicine stemming back to Hippocrates and to the 5000 year old civilization of the region. It is a school of medicine which touches on many a delicate points which may seem unimaginable within the realm of modern allopathic medicine. This practice of ancient medicine besides shedding light on various possible theoretical modern day disorders serves as a vast resource for therapeutics...
July 28, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28735599/effectiveness-of-the-metslim-lifestyle-intervention-targeting-individuals-of-low-socio-economic-status-and-different-ethnic-origins-with-elevated-waist-to-height-ratio
#20
Andrea J Bukman, Dorit Teuscher, Agnes Meershoek, Reint Jan Renes, Marleen A van Baak, Edith Jm Feskens
OBJECTIVE: To evaluate whether the lifestyle intervention MetSLIM targeting individuals of low socio-economic status of Turkish, Moroccan and Dutch origin was successful in improving waist circumference and other cardiometabolic risk factors, lifestyle behaviour and quality of life. DESIGN: A quasi-experimental intervention study (Netherlands Trial Register NTR3721). The intervention group participated in a 12-month combined dietary and physical activity programme...
July 24, 2017: Public Health Nutrition
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