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Giuseppe Maiolino, Alberto Flego, Gian Paolo Rossi
OBJECTIVE: PA causes excess cardiovascular (CV) damage, but whether it worsens prognosis remained uncertain as there are no prospective studies. To compare long-term outcome of the 1125 patients recruited in the PAPY study. DESIGN AND METHOD: 11.2% of the PAPY study patients had PA: 6.4% idiopathic hyperaldosteronism (IHA) received medical therapy; 4,8% aldosterone-producing adenoma (APA) required adrenalectomy. Endpoints were total and CV mortality, major adverse cardiovascular events (MACE) and total CV events...
September 2016: Journal of Hypertension
Yoshihiro Fujimori, Yoshihiro Bouike, Kenneth Nollet, Hitoshi Miki
On January 17, 1995, a magnitude 7.3 earthquake occurred in southern Hyogo Prefecture, a substantially urban area of Japan's main island, Honshu. Now known as the Hanshin-Awaji Earthquake, this disaster damaged or destroyed 639 686 houses and took 6434 lives. Within the disaster area, the Japanese Red Cross (JRC) Hyogo Blood Center had regional responsibilities for collecting, testing, processing, storing, and distributing blood components, including red blood cells (RBCs), fresh frozen plasma (FFP) and platelet concentrates (PLTs)...
October 2016: Transfusion and Apheresis Science
Natalio Extremera, Lourdes Rey
A growing body of research has demonstrated that deficits in well-being may be related to increased suicide risk, but there is only a limited number of studies that have focused on specific protective factors that can serve as a buffer against suicidal ideation and behaviours. Given that unemployment may be a factor leading to increased risk for suicide, this study assessed whether perceived EI might be a potential moderator in the relationship between life satisfaction/happiness and suicidal behaviours in a relatively large sample of unemployed individuals...
2016: PloS One
Giuseppe Maiolino, Alberto Flego, Gian Paolo Rossi
OBJECTIVE: PA causes excess cardiovascular (CV) damage, but whether it worsens prognosis remained uncertain as there are no prospective studies. To compare long-term outcome of the 1125 patients recruited in the PAPY study. DESIGN AND METHOD: 11.2% of the PAPY study patients had PA: 6.4% idiopathic hyperaldosteronism (IHA) received medical therapy; 4,8% aldosterone-producing adenoma (APA) required adrenalectomy. Endpoints were total and CV mortality, major adverse cardiovascular events (MACE) and total CV events...
September 2016: Journal of Hypertension
J K Pepper, K M Ribisl, N T Brewer
BACKGROUND: More US adolescents use e-cigarettes than smoke cigarettes. Research suggests flavoured e-cigarettes appeal to youth, but little is known about perceptions of and reasons for attraction to specific flavours. METHODS: A national sample of adolescents (n=1125) ages 13-17 participated in a phone survey from November 2014 to June 2015. We randomly assigned adolescents to respond to survey items about 1 of 5 e-cigarette flavours (tobacco, alcohol, menthol, candy or fruit) and used regression analysis to examine the impact of flavour on interest in trying e-cigarettes and harm beliefs...
September 15, 2016: Tobacco Control
Kamran Sattar, Sue Roff
BACKGROUND: Medical Professionalism is recognized as a cultural construct. We explore perceptions of the severity of lapses in professionalism of undergraduate medical students at two medical schools with different cultural contexts. METHODS: Respondents from two medical schools (Saudi Arabia & UK) recommended sanctions for the first time, unmitigated lapses in academic professionalism, using the Dundee Polyprofessionalism Inventory 1: Academic Integrity. RESULTS: While more than two-thirds of the recommended sanctions for the 30 items of poor professionalism were fully or nearly congruent among the 1125 respondents, there were substantial differences in recommended response for one-third of the items, with a strong tendency for the Saudi students to recommend more lenient sanctions than the Scottish students...
September 15, 2016: Medical Teacher
Nicola A Hanania, Phillip Korenblat, Kenneth R Chapman, Eric D Bateman, Petr Kopecky, Pierluigi Paggiaro, Akihito Yokoyama, Julie Olsson, Sarah Gray, Cecile T J Holweg, Mark Eisner, Charles Asare, Saloumeh K Fischer, Kun Peng, Wendy S Putnam, John G Matthews
BACKGROUND: In phase 2 trials, lebrikizumab, an anti-interleukin-13 monoclonal antibody, reduced exacerbation rates and improved FEV1 in patients with uncontrolled asthma, particularly in those with high concentrations of type 2 biomarkers (eg, periostin or blood eosinophils). We undertook replicate phase 3 studies to assess the efficacy and safety of lebrikizumab in patients with uncontrolled asthma despite inhaled corticosteroids and at least one second controller medication. METHODS: Adult patients with uncontrolled asthma, pre-bronchodilator FEV1 40-80% predicted, and stable background therapy were randomly assigned (1:1:1) with an interactive voice-web-based response system to receive lebrikizumab 37·5 mg or 125 mg, or placebo subcutaneously, once every 4 weeks...
October 2016: Lancet Respiratory Medicine
Guillermina Campos-Valdez, Luis Miguel Canseco-Ávila, Fernando González-Noriega, Oscar Alfaro-Zebadua, Ismael Yadird Nava-Medecigo, Enedina Jiménez-Cardoso
OBJECTIVE: To determine the Trypanosoma cruzi infection prevalence in 1125 pregnant women and the transmission frequency to their children from Tapachula and Palenque, Chiapas. MATERIALS AND METHODS: We determined the prevalence by serology tests and the transmission frequency by polymerase chain reaction (PCR) and T. cruzi reactivity capacity after 12 months. RESULTS: Total maternal infection prevalence were 23/1 125 (2.04%), 9/600 (1.5%) were from Tapachula and 14/525 (2...
June 2016: Salud Pública de México
Connie L Tompkins, David W Brock
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Sibel Vildan Altin, Stephanie Stock
BACKGROUND: Findings on the association between health literacy skills and patient-reported outcomes such as satisfaction with health care delivery are scarce. We explored the extent to which subjective health literacy skills and the perception of the application of patient-centered communication and shared decision-making are associated with patient's satisfaction with care received by their general practitioner (GP). METHODS: A nationwide cross sectional survey was administered in a random sample of 1125 German adults...
2016: BMC Health Services Research
Zahra Eslami, Mahsa Torabizadeh, Zahra Talebpour, Mohammad Talebpour, Alireza Ghassempour, Hassan Y Aboul-Enein
During a decade and more since its discovery, the emerging physiological roles of ghrelin in mammalian are increasingly being introduced, proposing a critical need for its quantification in biological milieu. Here in, a simple and sensitive single-step method for extraction and quantification of ghrelin in human plasma was developed and validated using stir bar sorptive extraction (SBSE) followed by high-performance liquid chromatography (HPLC) with diode array detection (DAD) coupled to mass spectrometry (MS)...
August 9, 2016: Journal of Chromatographic Science
Mingzhi Zhao, Wei Wei, Long Cheng, Yao Zhang, Feilin Wu, Fuchu He, Ping Xu
In this paper, a membrane protein enrichment method composed of ultra-centrifugation and detergent-based extraction was first developed based on MCF7 cell line. Then in-solution digestion with detergents and eFASP (enhanced filter aided sample preparation) with detergents were compared with the time consuming in-gel digestion method. Among the in-solution digestion strategies, the eFASP combined with RapiGest identified 1125 membrane proteins. Similarly, the eFASP combined with SDC identified 1069 membrane proteins, however, the in-gel digestion characterized 1091 membrane proteins...
August 3, 2016: Journal of Proteome Research
Lotte Kok, Milou S Sep, Dieuwke S Veldhuijzen, Sandra Cornelisse, Arno P Nierich, Joost van der Maaten, Peter M Rosseel, Jan Hofland, Jan M Dieleman, Christiaan H Vinkers, Marian Joëls, Diederik van Dijk, Manon H Hillegers
BACKGROUND: Post-traumatic stress disorder (PTSD) and depression are common after cardiac surgery. Lifetime stress exposure and personality traits may influence the development of these psychiatric conditions. METHODS: Self-reported rates of PTSD and depression and potential determinants (i.e., trait anxiety and stress exposure) were established 1.5 to 4 years after cardiac surgery. Data was available for 1125 out of 1244 (90.4%) participants. Multivariable linear regressions were conducted to investigate mediating and/or moderating effects of trait anxiety on the relationship between stress exposure, and PTSD and depression...
July 21, 2016: Journal of Affective Disorders
Roger A Winkle, Julian W E Jarman, R Hardwin Mead, Gregory Engel, Melissa H Kong, William Fleming, Rob A Patrawala
BACKGROUND: Patients with a variety of clinical presentations undergo atrial fibrillation(AF) ablation. Long term ablation success rates can vary considerably. OBJECTIVES: To develop a clinical scoring system to predict long-term freedom from AF after ablation. METHODS: We retrospectively derived the scoring system on a Development Cohort(DC) of 1125 patients undergoing AF ablation and tested it prospectively in a Test Cohort(TC) of 937 patients undergoing AF ablation...
July 16, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Sarabjeet Singh, Abhishek Sharma, Navreet Sandhu, Kavita Mehta
OBJECTIVE: The aim of this study was to determine the prevalence of malocclusion and orthodontic treatment need in 13-18-year-old schoolchildren of Nalagarh, Himachal Pradesh, India using the Index of Orthodontic Treatment need (IOTN) and to analyze the treatment needs between males and females and correlation between the esthetic component (AC) and dental health component (DHC) of IOTN. SUBJECTS AND METHODS: The sample comprised 2000 school children (1125 females and 875 males) who had not undergone orthodontic treatment...
May 2016: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
László Romics, Judit Kocsis, Katalin Ormándi, Béla Ákos Molnár
INTRODUCTION: Screening, prevention and treatment of familial breast cancer require a multidisciplinary approach. New guidelines were published in the United Kingdom for the management of familial breast cancer. AIM: The authors summarise these new guidelines and analyse the relevant practice in Hungary. METHOD: Relevant guidelines of the National Institute for Health and Care Excellence and Familial Breast Cancer Report (NHS Scotland) are described...
July 2016: Orvosi Hetilap
Carla C Moreira, Alexander D Leung, Alik Farber, Denis Rybin, Gheorghe Doros, Jeffrey J Siracuse, Jeffrey Kalish, Mohammad H Eslami
BACKGROUND: Autologous great saphenous vein (GSV) has always been considered the gold standard conduit for infrainguinal revascularization. When GSV is inadequate or unavailable, alternative conduits have been used. In this study, we compared modern outcomes of different conduit types used in lower extremity bypass (LEB) for patients with critical limb ischemia (CLI). METHODS: The Vascular Study Group of New England database (2003-2014) was queried for patients who underwent infrageniculate bypass originating from the femoral arteries...
July 2016: Journal of Vascular Surgery
Barbara H Currier, Douglas W Van Citters
BACKGROUND: Antioxidants added to UHMWPE to prevent in vivo oxidation are important to the long-term performance of hip and knee arthroplasty. Diffused vitamin E antioxidant polyethylene raised questions about potential in vivo elution that could cause inflammatory reactions in periprosthetic tissues and also potentially leave the implant once again prone to oxidation. Currently, there is no information on the elution, if any, of antioxidants from implant polyethylene materials in vivo...
June 22, 2016: Clinical Orthopaedics and related Research
Cristian Rogel-Castillo, Roger Boulton, Arunwong Opastpongkarn, Guangwei Huang, Alyson E Mitchell
Concealed damage (CD) is defined as a brown discoloration of the kernel interior (nutmeat) that appears only after moderate to high heat treatment (e.g., blanching, drying, roasting, etc.). Raw almonds with CD have no visible defects before heat treatment. Currently, there are no screening methods available for detecting CD in raw almonds. Herein, the feasibility of using near-infrared (NIR) spectroscopy between 1125 and 2153 nm for the detection of CD in almonds is demonstrated. Almond kernels with CD have less NIR absorbance in the region related with oil, protein, and carbohydrates...
July 27, 2016: Journal of Agricultural and Food Chemistry
Sophie Joanisse, Joshua P Nederveen, Jeff M Baker, Tim Snijders, Carlo Iacono, Gianni Parise
Skeletal muscle possesses the ability to regenerate after injury, but this ability is impaired or delayed with aging. Regardless of age, muscle retains the ability to positively respond to stimuli, such as exercise. We examined whether exercise is able to improve regenerative response in skeletal muscle of aged mice. Twenty-two-month-old male C57Bl/6J mice (n = 20) underwent an 8-wk progressive exercise training protocol [old exercised (O-Ex) group]. An old sedentary (O-Sed) and a sedentary young control (Y-Ctl) group were included...
September 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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