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Qiang Li, Xu Zhou, Yue Wang, Jin Qian, Qingguo Zhang
Although facial paralysis is a fundamental feature of hemifacial microsomia, the frequency and distribution of nerve abnormalities in patients with hemifacial microsomia remain unclear. In this study, the authors classified 1125 cases with microtia (including 339 patients with hemifacial microsomia and 786 with isolated microtia) according to Orbital Distortion Mandibular Hypoplasia Ear Anomaly Nerve Involvement Soft Tissue Dependency (OMENS) scheme. Then, the authors performed an independent analysis to describe the distribution feature of nerve abnormalities and reveal the possible relationships between facial paralysis and the other 4 fundamental features in the OMENS system...
May 15, 2018: Journal of Craniofacial Surgery
Md Harunur Rashid, Mohammad Mahmudur Rahman, Ray Correll, Ravi Naidu
Mushroom cultivation has been increasing rapidly in Bangladesh. Arsenic (As) toxicity is widespread in the world and Bangladesh faces the greatest havoc due to this calamity. Rice is the staple food in Bangladesh and among all the crops grown, it is considered to be the main cause of As poisoning to its population after drinking water. Consequently, rice straw, an important growing medium of mushrooms in Bangladesh, is known to have high As content. The objective of this study was, therefore, to determine the concentrations of As in mushrooms cultivated in Bangladesh and to assess the health risk as well...
May 4, 2018: International Journal of Environmental Research and Public Health
Elham Mahmoudi, Philip Zazove, Michelle Meade, Michael M McKee
Importance: Hearing loss (HL) is common among older adults and is associated with poorer health and impeded communication. Hearing aids (HAs), while helpful in addressing some of the outcomes of HL, are not covered by Medicare. Objective: To determine whether HA use is associated with health care costs and utilization in older adults. Design, Setting, and Participants: This retrospective cohort study used nationally representative 2013-2014 Medical Expenditure Panel Survey data to evaluate the use of HAs among 1336 adults aged 65 years or older with HL...
April 26, 2018: JAMA Otolaryngology—Head & Neck Surgery
Jordi Corominas, Johanna M Colijn, Maartje J Geerlings, Marc Pauper, Bjorn Bakker, Najaf Amin, Laura Lores Motta, Eveline Kersten, Alejandro Garanto, Joost A M Verlouw, Jeroen G J van Rooij, Robert Kraaij, Paulus T V M de Jong, Albert Hofman, Johannes R Vingerling, Tina Schick, Sascha Fauser, Eiko K de Jong, Cornelia M van Duijn, Carel B Hoyng, Caroline C W Klaver, Anneke I den Hollander
PURPOSE: Genome-wide association studies and targeted sequencing studies of candidate genes have identified common and rare variants that are associated with age-related macular degeneration (AMD). Whole-exome sequencing (WES) studies allow a more comprehensive analysis of rare coding variants across all genes of the genome and will contribute to a better understanding of the underlying disease mechanisms. To date, the number of WES studies in AMD case-control cohorts remains scarce and sample sizes are limited...
April 26, 2018: Ophthalmology
Vivek Thakkar, Karen A Patterson, Wendy Stevens, Michelle Wilson, Janet Roddy, Joanne Sahhar, Susanna Proudman, Pravin Hissaria, Mandana Nikpour
Studies suggest elevated serum intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) levels may be markers of pulmonary arterial hypertension in systemic sclerosis (SSc-PAH). We sought to evaluate whether ICAM-1 and VCAM-1 levels are useful screening biomarkers for incident SSc-PAH. In this cross-sectional study, four groups were selected from the Australian Scleroderma Cohort Study: group 1 (n = 15) had definite PAH; group 2 (n = 19) had interstitial lung disease (ILD); group 3 (n = 30) were SSc-controls; and group 4 (n = 34) were healthy controls...
April 23, 2018: Clinical Rheumatology
Sean P Dempsey, Amy Sickman, William Scott Slagle
SIGNIFICANCE: This case illustrates a novel screening protocol for linezolid-induced toxic optic neuropathy. PURPOSE: To present a case report and analysis of linezolid-induced optic neuropathies in adult patients to develop screening recommendations. CASE REPORT: A case report of optic neuropathy from extended use of linezolid illustrates its potential effects on vision. We conduct a retrospective analysis of 39 reported cases to derive a recommended screening protocol for linezolid-induced toxic optic neuropathy in adult patients...
May 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
K Kridin
BACKGROUND: Peripheral eosinophilia has been reported in 50-60% of bullous pemphigoid (BP) patients and correlated positively with disease severity. The association of peripheral eosinophilia with the different morphological characteristics of BP and the presence of tissue eosinophilia has not been established. METHODS: The study was designed as a case-control study. The diagnosis of BP was grounded on the well-established immunopathological criteria. Five age-, sex-, and ethnicity-matched control subjects were randomly selected for each BP patient...
April 16, 2018: British Journal of Dermatology
Huan-Cheng Chang, Chuan-Fa Hsieh, Disline Manli Tantoh, Pei-Chieh Ko, Ya-Yu Kung, Mei-Chi Lin, Yi-Ching Liaw, Yung-Po Liaw
Aim: To investigate factors, especially modifiable factors associated with high-density lipoprotein (HDL) in Taiwanese based on sex and menopausal status. Materials and Methods: Participants comprised 2022 men and 2392 women (1267 menopausal and 1125 non-menopausal) aged ≥30 years who resided in Pingzhen district, Taoyuan from 2006-2011. Their data, obtained through questionnaires and measurements were retrieved from the Li-Shin Hospital. Results: Higher HDL was associated with total cholesterol, underweight, and alcohol drinking in both men and women...
March 27, 2018: Oncotarget
Seyed Amir Zarei, Keivan Akhtari, Mohammad Piltan, Shaaban M Kamel, Joel T Mague
The dimer of 9-anthraldehyde, namely heptacyclo[,9 .03,8 .011,16 .017,22 .023,28 ]octacosa-3,5,7,11,13,15,17(22),18,20,23(28),24,26-dodecaene-1,9-carbaldehyde, C30 H20 O2 , has been synthesized by refluxing an ethanol solution in the presence of M(ClO4 )2 and 1,3-diaminopropan-2-ol (M = Co2+ or Cu2+ ). Its structure has been determined by single-crystal X-ray diffraction, showing it to be a new polymorph, referred to as polymorph II, in the monoclinic space group P21 /n. It is compared with the previously reported triclinic modification [Ehrenberg (1968)...
April 1, 2018: Acta Crystallographica. Section C, Structural Chemistry
Shaoxiong Xie, Jiageng Xu, Yu Chen, Zhi Tan, Rui Nie, Qingyuan Wang, Jianguo Zhu
A sort of tungsten/chromium(W/Cr) co-doped bismuth titanate (BIT) ceramics (Bi₄Ti2.95 W0.05 O12.05 + 0.2 wt % Cr₂O₃, abbreviate to BTWC) are ordinarily sintered between 1050 and 1150 °C, and the indentation behavior and mechanical properties of ceramics sintered at different temperatures have been investigated by both nanoindentation and microindentation technology. Firstly, more or less Bi₂Ti₂O₇ grains as the second phase were found in BTWC ceramics, and the grain size of ceramics increased with increase of sintering temperatures...
March 27, 2018: Materials
Zhichang Qiu, Ningyang Li, Xiaoming Lu, Zhenjia Zheng, Mingjie Zhang, Xuguang Qiao
Black garlic is a distinctive garlic deep-processed product made from fresh garlic at high temperature and controlled humidity. To explore microbial community structure, diversity and metabolic potential during the 12days of the black garlic processing, Illumina MiSeq sequencing technology was performed to sequence the 16S rRNA V3-V4 hypervariable region of bacteria. A total of 677,917 high quality reads were yielded with an average read length of 416bp. Operational taxonomic units (OTU) clustering analysis showed that the number of species OTUs ranged from 148 to 1974, with alpha diversity increasing remarkably, indicating the high microbial community abundance and diversity...
April 2018: Food Research International
Elie El Rassy, Ziad Bakouny, Fouad Aoun, Fadi G Haddad, Ghassan Sleilaty, Tarek Assi, Joseph Kattan
AIM: To determine which of the approved immune checkpoint inhibitors is the optimal treatment in metastatic urothelial bladder cancer. METHODS & MATERIALS: Only the pivotal Phase III trials of second-line metastatic urothelial bladder cancer were included in this network meta-analysis. RESULTS: This NMA included three pooled trials (NCT00315237, NCT02256436 and NCT02302807) of 1125 participants. Pembrolizumab was the only treatment with positive effect on overall survival compared with the best supportive care...
March 22, 2018: Immunotherapy
Valeria Prigione, Bruno Trocini, Federica Spina, Anna Poli, Davide Romanisio, Samuele Giovando, Giovanna Cristina Varese
Tannins are a complex family of polyphenolic compounds, widely distributed in the plant kingdom where they act as growth inhibitors towards many microorganisms including bacteria, yeasts, and fungi. Tannins are one of the major components of tannery wastewaters and may cause serious environmental pollution. In the present study, four different tannins (the hydrolysable chestnut ellagitannin and tara gallotannin and the condensed quebracho and wattle tannins) were characterized from a mycological point of view with the aim of selecting fungal strains capable of growing in the presence of high tannin concentration and thus potentially useful in industrial biotransformations of these compounds or in the bioremediation of tannery wastewaters...
March 18, 2018: Applied Microbiology and Biotechnology
Dong-Wan Kim, Hoon-Gu Kim, Joo-Hang Kim, Keunchil Park, Hoon-Kyo Kim, Joung Soon Jang, Bong-Seog Kim, Jin-Hyoung Kang, Kyung Hee Lee, Sang-We Kim, Hun Mo Ryoo, Jin-Soo Kim, Ki Hyeong Lee, Jung Hye Kwon, Jin-Hyuk Choi, Sang Won Shin, Seokyung Hahn, Dae Seog Heo
Purpose: This randomized phase III study was designed to compare the efficacy and safety of irinotecan plus cisplatin (IP) over etoposide plus cisplatin (EP) in Korean patients with extensive-disease small-cell lung cancer (SCLC). Materials and Methods: Patients were randomly assigned to receive IP, composed of irinotecan 65 mg/m2 intravenously on days 1 and 8 + cisplatin 70 mg/m2 intravenously on day1 every 3 weeks, or EP, composed of etoposide 100 mg/m2 intravenously on days 1, 2, 3+cisplatin 70 mg/m2 intravenously on day 1, every 3 weeks for a maximum of six cycles, until disease progression, or until unacceptable toxicity occurred...
March 12, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
Ying-Chun Chen, Lin Zhang, Er-Nan Li, Li-Xiang Ding, Gen-Ai Zhang, Yu Hou, Wei Yuan
BACKGROUND: The optimal drainage after debridement for treating postoperative SSI is still controversial. We comprehensively compared single-tube drainage method with double-tube drainage method. MATERIALS AND METHODS: We retrospectively analyzed 1125 patients with lumbar degenerative disease who received lumbar surgery. Among them, 26 patients were diagnosed as postoperative SSI and divided into two groups, including single-tube drainage group (1 drain) and double-tube drainage group (2 drains)...
March 3, 2018: World Neurosurgery
Maarten Timmers, Vikash Sinha, Borje Darpo, Brian Smith, Randy Brown, Hongqi Xue, Georg Ferber, Johannes Streffer, Alberto Russu, Luc Tritsmans, Bhavna Solanki, Jennifer Bogert, Luc Van Nueten, Giacomo Salvadore, Partha Nandy
Nonclinical assays with JNJ-54861911, a β-secretase 1 inhibitor have indicated that at high concentrations, it may delay cardiac repolarization. A 4-way crossover thorough QT (TQT) study was performed in 64 healthy subjects with 50 and 150 mg JNJ-54861911 once daily for 7 days, placebo, and 400 mg moxifloxacin. Retrospective high-precision QT (HPQT) analysis was performed on serial elecrocardiograms extracted from first-in-human single-ascending dose (SAD) and multiple-ascending dose (MAD) studies to evaluate if early studies could detect and predict QT effect...
March 5, 2018: Journal of Clinical Pharmacology
Jih-Zu Yu, Bing Huei Chen, Ali Güncan, Remzi Atlihan, Ayhan Gökçe, Cecil L Smith, Ebru Gümüs, Hsin Chi
We compared rearing Harmonia dimidiata (F.) (Coleoptera: Coccinellidae) on four combinations of Aphis gossypii Glover (Hemiptera: Aphididae), and eggs of Bactrocera dorsalis Hendel (Diptera: Tephritidae), using the age-stage, two-sex life table. The four combinations were: both larvae and adults were reared on aphids; larvae were reared on aphids and adults were reared on fresh fruit fly eggs; larvae were reared on lyophilized fruit fly eggs and adults were reared on aphids; and larvae were reared on lyophilized eggs and adults were reared on fresh eggs...
April 2, 2018: Journal of Economic Entomology
Gian Paolo Rossi, Giuseppe Maiolino, Alberto Flego, Anna Belfiore, Giampaolo Bernini, Bruno Fabris, Claudio Ferri, Gilberta Giacchetti, Claudio Letizia, Mauro Maccario, Francesca Mallamaci, Maria Lorenza Muiesan, Massimo Mannelli, Aurelio Negro, Gaetana Palumbo, Gabriele Parenti, Ermanno Rossi, Franco Mantero
Primary aldosteronism (PA) causes cardiovascular damage in excess to the blood pressure elevation, but there are no prospective studies proving a worse long-term prognosis in adrenalectomized and medically treated patients. We have, therefore, assessed the outcome of PA patients according to treatment mode in the PAPY study (Primary Aldosteronism Prevalence in Hypertension) patients, 88.8% of whom were optimally treated patients with primary (essential) hypertension (PH), and the rest had PA and were assigned to medical therapy (6...
April 2018: Hypertension
Carolyn E Schwartz, Brian Stucky, Carly S Rivers, Vanessa K Noonan, Joel A Finkelstein
OBJECTIVE: To investigate response shift effects in spinal cord injury (SCI) over five years' post-injury. DESIGN: Prospective cohort study observed at one-, two- and five-years post-SCI. SETTING: 31 specialized Canadian SCI centers PARTICIPANTS: Sample included 1125, 760, and 219 at one-, two-, and five-years post-SCI. INTERVENTIONS: NA MAIN OUTCOME MEASURES: Patient-reported outcomes included the Short-Form 36v2 , and the Life Satisfaction-11...
February 23, 2018: Archives of Physical Medicine and Rehabilitation
Mark J Amirtharaj, Dean Wang, Michael H McGraw, Christopher L Camp, Ryan A Degen, David M Dines, Joshua S Dines
PURPOSE: (1) Define the epidemiologic trend of distal clavicle excision (DCE) for acromioclavicular (AC) joint arthritis among board-eligible orthopaedic surgeons in the United States, (2) describe the rates and types of reported complications of open and arthroscopic DCE, and (3) evaluate the effect of fellowship training on preferred technique and reported complication rates. METHODS: The American Board of Orthopaedic Surgery (ABOS) database was used to identify DCE cases submitted by ABOS Part II Board Certification examination candidates...
February 21, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
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