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Dong-Wan Kim, Hoon-Gu Kim, Joo-Hang Kim, Keunchil Park, Hoon-Kyo Kim, Joung Soon Jang, Bong-Seog Kim, Jin-Hyoung Kang, Kyung Hee Lee, Sang-We Kim, Hun Mo Ryoo, Jin-Soo Kim, Ki Hyeong Lee, Jung Hye Kwon, Jin-Hyuk Choi, Sang Won Shin, Seokyung Hahn, Dae Seog Heo
Purpose: This randomized phase III study was designed to compare the efficacy and safety of irinotecan plus cisplatin (IP) over etoposide plus cisplatin (EP) in Korean patients with extensive-disease small-cell lung cancer (SCLC). Materials and Methods: Patients were randomly assigned to receive IP, composed of irinotecan 65 mg/m2 intravenously on days 1 and 8 + cisplatin 70 mg/m2 intravenously on day1 every 3 weeks, or EP, composed of etoposide 100 mg/m2 intravenously on days 1, 2, 3+cisplatin 70 mg/m2 intravenously on day 1, every 3 weeks for a maximum of six cycles, until disease progression, or until unacceptable toxicity occurred...
March 12, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
Ying-Chun Chen, Lin Zhang, Er-Nan Li, Li-Xiang Ding, Gen-Ai Zhang, Yu Hou, Wei Yuan
BACKGROUND: The optimal drainage after debridement for treating postoperative SSI is still controversial. We comprehensively compared single-tube drainage method with double-tube drainage method. MATERIALS AND METHODS: We retrospectively analyzed 1125 patients with lumbar degenerative disease who received lumbar surgery. Among them, 26 patients were diagnosed as postoperative SSI and divided into two groups, including single-tube drainage group (1 drain) and double-tube drainage group (2 drains)...
March 3, 2018: World Neurosurgery
Maarten Timmers, Vikash Sinha, Borje Darpo, Brian Smith, Randy Brown, Hongqi Xue, Georg Ferber, Johannes Streffer, Alberto Russu, Luc Tritsmans, Bhavna Solanki, Jennifer Bogert, Luc Van Nueten, Giacomo Salvadore, Partha Nandy
Nonclinical assays with JNJ-54861911, a β-secretase 1 inhibitor have indicated that at high concentrations, it may delay cardiac repolarization. A 4-way crossover thorough QT (TQT) study was performed in 64 healthy subjects with 50 and 150 mg JNJ-54861911 once daily for 7 days, placebo, and 400 mg moxifloxacin. Retrospective high-precision QT (HPQT) analysis was performed on serial elecrocardiograms extracted from first-in-human single-ascending dose (SAD) and multiple-ascending dose (MAD) studies to evaluate if early studies could detect and predict QT effect...
March 5, 2018: Journal of Clinical Pharmacology
Jih-Zu Yu, Bing Huei Chen, Ali Güncan, Remzi Atlihan, Ayhan Gökçe, Cecil L Smith, Ebru Gümüs, Hsin Chi
We compared rearing Harmonia dimidiata (F.) (Coleoptera: Coccinellidae) on four combinations of Aphis gossypii Glover (Hemiptera: Aphididae), and eggs of Bactrocera dorsalis Hendel (Diptera: Tephritidae), using the age-stage, two-sex life table. The four combinations were: both larvae and adults were reared on aphids; larvae were reared on aphids and adults were reared on fresh fruit fly eggs; larvae were reared on lyophilized fruit fly eggs and adults were reared on aphids; and larvae were reared on lyophilized eggs and adults were reared on fresh eggs...
February 27, 2018: Journal of Economic Entomology
Gian Paolo Rossi, Giuseppe Maiolino, Alberto Flego, Anna Belfiore, Giampaolo Bernini, Bruno Fabris, Claudio Ferri, Gilberta Giacchetti, Claudio Letizia, Mauro Maccario, Francesca Mallamaci, Maria Lorenza Muiesan, Massimo Mannelli, Aurelio Negro, Gaetana Palumbo, Gabriele Parenti, Ermanno Rossi, Franco Mantero
Primary aldosteronism (PA) causes cardiovascular damage in excess to the blood pressure elevation, but there are no prospective studies proving a worse long-term prognosis in adrenalectomized and medically treated patients. We have, therefore, assessed the outcome of PA patients according to treatment mode in the PAPY study (Primary Aldosteronism Prevalence in Hypertension) patients, 88.8% of whom were optimally treated patients with primary (essential) hypertension (PH), and the rest had PA and were assigned to medical therapy (6...
February 26, 2018: Hypertension
Carolyn E Schwartz, Brian Stucky, Carly S Rivers, Vanessa K Noonan, Joel A Finkelstein
OBJECTIVE: To investigate response shift effects in spinal cord injury (SCI) over five years' post-injury. DESIGN: Prospective cohort study observed at one-, two- and five-years post-SCI. SETTING: 31 specialized Canadian SCI centers PARTICIPANTS: Sample included 1125, 760, and 219 at one-, two-, and five-years post-SCI. INTERVENTIONS: NA MAIN OUTCOME MEASURES: Patient-reported outcomes included the Short-Form 36v2 , and the Life Satisfaction-11...
February 23, 2018: Archives of Physical Medicine and Rehabilitation
Mark J Amirtharaj, Dean Wang, Michael H McGraw, Christopher L Camp, Ryan A Degen, David M Dines, Joshua S Dines
PURPOSE: (1) Define the epidemiologic trend of distal clavicle excision (DCE) for acromioclavicular (AC) joint arthritis among board-eligible orthopaedic surgeons in the United States, (2) describe the rates and types of reported complications of open and arthroscopic DCE, and (3) evaluate the effect of fellowship training on preferred technique and reported complication rates. METHODS: The American Board of Orthopaedic Surgery (ABOS) database was used to identify DCE cases submitted by ABOS Part II Board Certification examination candidates...
February 21, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
Elena Gomes de Matos, Tessa-Virginia Hannemann, Josefine Atzendorf, Ludwig Kraus, Daniela Piontek
BACKGROUND: The abuse of new psychoactive substances (NPS) and methamphetamine has severe adverse effects. Here we provide the first report of regional patterns in NPS and methamphetamine consumption in Germany, on the basis of epidemiologic data from six federal states (Bavaria, Hamburg, Hesse, North Rhine-Westphalia, Saxony, and Thuringia). METHODS: Data were derived from the 2015 Epidemiological Survey of Substance Abuse (Epidemiologischer Suchtsurvey) and supplemented with additional cases from the federal states that were studied...
January 26, 2018: Deutsches Ärzteblatt International
Astrid de Wind, Micky Scharn, Goedele A Geuskens, Allard J van der Beek, Cécile R L Boot
BACKGROUND: An increasing number of retirees continue to work beyond retirement despite being eligible to retire. As the prevalence of chronic disease increases with age, working beyond retirement may go along with having a chronic disease. Working beyond retirement may be different for retirees with and without chronic disease. We aim to investigate whether demographic, socioeconomic and work characteristics, health and social factors predict working beyond retirement, in workers with and without a chronic disease...
February 17, 2018: BMC Public Health
Lauren N Ko, Anna C Garza-Mayers, Jessica St John, Lauren Strazzula, Priyanka Vedak, Radhika Shah, Allison S Dobry, Sowmya R Rao, Leslie W Milne, Blair Alden Parry, Daniela Kroshinsky
Importance: Each year, cellulitis leads to 650 000 hospital admissions and is estimated to cost $3.7 billion in the United States. Previous literature has demonstrated a high misdiagnosis rate for cellulitis, which results in unnecessary antibiotic use and health care cost. Objective: To determine whether dermatologic consultation decreases duration of hospital stay or intravenous antibiotic treatment duration in patients with cellulitis. Design, Setting, and Participants: This randomized clinical trial was conducted in a large urban tertiary care hospital between October 2012 and January 2017, with 1-month follow-up duration...
February 16, 2018: JAMA Dermatology
Yunting Lei, Yuxing Xu, Christian Hettenhausen, Chengkai Lu, Guojing Shen, Cuiping Zhang, Jing Li, Juan Song, Honghui Lin, Jianqiang Wu
BACKGROUND: Soil salinity is an important factor affecting growth, development, and productivity of almost all land plants, including the forage crop alfalfa (Medicago sativa). However, little is known about how alfalfa responds and adapts to salt stress, particularly among different salt-tolerant cultivars. RESULTS: Among seven alfalfa cultivars, we found that Zhongmu-1 (ZM) is relatively salt-tolerant and Xingjiang Daye (XJ) is salt-sensitive. Compared to XJ, ZM showed slower growth under low-salt conditions, but exhibited stronger tolerance to salt stress...
February 15, 2018: BMC Plant Biology
Masoud Mollaee, Xiushan Zhu, Jie Zong, Kort Wiersma, Arturo Chavez-Pirson, Mehmetcan Akbulut, Yushi Kaneda, Lloyd LaComb, Axel Schülzgen, N Peyghambarian
An all-fiber amplifier for a single-frequency blue laser was demonstrated for the first time, to the best of our knowledge. Over 150 mW continuous-wave single-transverse-mode blue laser output was obtained with a 10 m 1000 ppm thulium-doped fluoride fiber pumped by a 1125 nm fiber laser at a power of 2 W. The output power was limited due to the onset of the competitive lasing at 783 nm. Photodarkening and photo-curing of the thulium-doped fiber amplifier were also studied and analyzed.
February 1, 2018: Optics Letters
Ying Han, Ning Lin, Tianjun Xu, Tieqiang Li, Jie Tian, Yongchun Zhu, Yitai Qian
Sponge-like amorphous silicon was prepared by reacting silicon tetrachloride with magnesium powder. When the as-prepared sample was applied as an anode in rechargeable batteries, it exhibited a reversible capacity of 1125 mA h g-1 after 100 cycles at 1 A g-1 for Li-ion batteries (LIBs) and a reversible capacity of 176 mA h g-1 at 100 mA g-1 over 100 cycles for Na-ion batteries (NIBs).
February 1, 2018: Nanoscale
Luhao Wang, Chunfang Qiu, Xiangdong Guan, Minying Chen, Juan Chen, Xiang Si, Zhicheng Du, Yanqiu Liu, Bin Ouyang
Fluid overload is associated with increased morbidity and mortality in critically ill patients. However, researches rarely study the precise start or end point of fluid removal and no protocol was developed to control the fluid removal process. We hypothesized that individualized fluid removal with ultrasound-guided protocol could improve the efficacy and safety of fluid removal in post-resuscitated critically ill patients. A quasi-experimental, before and after trial was conducted to identify the benefits of ultrasound-guided fluid removal...
January 18, 2018: Shock
A K Nor Hasyimah, S Jinap, M Sanny
This study investigated the simultaneous formation of polycyclic aromatic hydrocarbons (PAHs) and heterocyclic aromatic amines (HCAs) in gas-grilled beef satay at different temperatures (150°C, 200°C, 250°C, 300°C, and 350°C). Solid-phase extraction (SPE) was used for sample clean-up. Fifteen PAHs were determined using high performance liquid chromatography with fluorescence detection (HPLC-FLD) and nine HCAs were quantified using liquid chromatography tandem-mass spectrometry (LC-MS/MS) with a gradient programme...
January 15, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Galit Geulayov, Ilya Novikov, Daniella Dankner, Rachel Dankner
OBJECTIVES: To investigate the overall and the sex-specific association of preoperative and one-year post coronary artery bypass (CABG) surgery symptoms of depression and anxiety with 11-year all-cause mortality. METHODS: A multicenter prospective study including 1125 patients who completed the Hospital Anxiety and Depression Scale (HADS) before an elective CABG surgery, of whom 850 completed the HADS again at one-year follow-up. Information on all-cause mortality was obtained through the Israeli Ministry of Internal Affairs Register...
February 2018: Journal of Psychosomatic Research
Ting Tian, Jie Wang, Peng Huang, Jun Li, Rongbin Yu, Haozhi Fan, Xueshan Xia, Yaping Han, Yun Zhang, Ming Yue
Polymorphisms within NF-κB pathway genes may be linked to hepatitis C virus (HCV) infection susceptibility and outcomes. We investigated the associations between single nucleotide polymorphisms (SNPs) in NF-κB and the susceptibility as well as resolution of HCV infection. A Chinese population, including 1125 uninfected control cases, 558 cases with spontaneous viral clearance and 898 cases with persistent HCV infection, was genotyped for four SNPs (rs11820062, rs230530, rs1056890 and rs3774963) using a TaqMan assay...
January 8, 2018: Scientific Reports
Vania Cruz-Ramón, Paulina Chinchilla-López, Oscar Ramírez-Pérez, Xingshun Qi, Nahum Méndez-Sánchez
The early diagnosis of primary sclerosing cholangitis, hepatocellular carcinoma, and cholangiocarcinoma is often challenging. In a recent study in 134 patients (Arbelaiz, Hepatology 2017; 66:1125-1143), it was reported that specific proteins found in serum extracellular vesicles of patients with primary sclerosing cholangitis, hepatocellular carcinoma,orcholangiocarcinomamay be useful as noninvasive diagnostic and prognostic tools. This current article critically appraises this study.
January 2018: Annals of Hepatology
Karl-Erik Andersson, Lori Birder
The symptoms of interstitial cystitis (IC)/bladder pain syndrome (BPS) may have multiple causes and involve many contributing factors. Traditional treatments (intravesical instillations) have had a primary focus on the bladder as origin of symptoms without adequately considering the potential influence of other local (pelvic) or systemic factors. Systemic pharmacological treatments have had modest success. A contributing factor to the low efficacy is the lack of phenotyping the patients. Individualized treatment based on is desirable, but further phenotype categorization is needed...
December 2017: International Neurourology Journal
Aderivaldo Cabral Dias Filho, Paulo Gonçalves de Oliveira
INTRODUCTION: Ongoing controversy surrounds the role of atmospheric temperature in the incidence of intravaginal testicular torsion (iTT). This debate may be attributed to inadequate research methodology. As environmental risk factors have been successfully investigated with distributed lag non-linear model regression (DLNM), we applied this methodology to investigate the association between daily mean atmospheric temperatures (Tmean) and daily incidences of intravaginal testicular torsion (iTT) in our region...
December 19, 2017: Journal of Pediatric Urology
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