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https://www.readbyqxmd.com/read/28926628/application-of-raman-spectroscopy-in-type-2-diabetes-screening-in-blood-using-leucine-and-isoleucine-amino-acids-as-biomarkers-and-in-comparative-anti-diabetic-drugs-efficacy-studies
#1
Zephania Birech, Peter Waweru Mwangi, Fredrick Bukachi, Keith Makori Mandela
Diabetes is an irreversible condition characterized by elevated blood glucose levels. Currently, there are no predictive biomarkers for this disease and the existing ones such as hemoglobin A1c and fasting blood glucose are used only when diabetes symptoms are noticed. The objective of this work was first to explore the potential of leucine and isoleucine amino acids as diabetes type 2 biomarkers using their Raman spectroscopic signatures. Secondly, we wanted to explore whether Raman spectroscopy can be applied in comparative efficacy studies between commercially available anti-diabetic drug pioglitazone and the locally used anti-diabetic herbal extract Momordica spinosa (Gilg...
2017: PloS One
https://www.readbyqxmd.com/read/28923704/cloning-characterisation-docking-and-expression-analysis-of-3-beta-hydroxysteroid-dehydrogenase-during-ontogenetic-development-and-annual-reproductive-cycles-in-catfish-clarias-batrachus
#2
Irfan Ahmad Bhat, Mohd Ashraf Rather, Mir Ishfaq Nazir, Gireesh-Babu Pathakota, Mukunda Goswami, J K Sundaray, Rupam Sharma
Fish like higher animals, have a well-defined mechanism to produce sex steroids that play a critical role in gonadal development and maturation. In this study, we aimed to analyse the expression pattern of 3β-HSD in different tissues, during ontogenetic development and gonadal recrudescence of Clarias batrachus. A full-length cDNA of 1617 bp including an open reading frame (ORF) of 1125 bp encoding 374 amino acids was isolated from testes of C. batrachus. The docking analysis between C. batrachus 3β-HSD protein and eurycomanone exhibited high binding affinity toward each other with total energy of -108...
September 11, 2017: Theriogenology
https://www.readbyqxmd.com/read/28920969/-disease-burden-of-extreme-treatment-anxiety-quality-of-life-for-patients-with-and-without-extreme-dental-treatment-anxiety
#3
J H Vermaire, C M H H van Houtem, J N Ross, A A Schuller
In this study, a comparison was made between disease-specific (oral health-related) quality of life (OHQoL), measured with the OHIP-14 questionnaire, and generic (general health-related) quality of life (GHQoL), measured with the EQ5D-5L questionnaire, in patients with and without extreme dental treatment anxiety. A total of 76 patients who could not be treated due to extreme dental treatment anxiety were referred to a centre for special dentistry. These patients were matched, according to age, gender and socioeconomic status, with participants in an epidemiological study on oral health (n = 1125)...
September 2017: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/28898332/-prediction-of-hospital-mortality-of-st-elevation-myocardial-infarction-using-timi-score
#4
Héctor Ugalde, María Cecilia Yubini, Sebastián Rozas, María Ignacia Sanhueza, Hernán Jara
BACKGROUND: Thrombolysis in myocardial infarction risk score (TIMI-RS) was designed to predict early mortality in patients with a ST elevation acute myocardial infarction (STEAMI). AIM: To evaluate the predictive capacity for hospital mortality of TIMI-RS. MATERIAL AND METHODS: Patients with ≤ 12-hour evolution STEAMI were selected from a prospective registry of all patients hospitalized in our coronary unity within January 1988 and December 2005...
May 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28878813/health-utilities-for-chronic-low-back-pain
#5
Anna Lene Seidler, Constanze Rethberg, Jochen Schmitt, Albert Nienhaus, Andreas Seidler
BACKGROUND: Chronic low back pain (LBP) is a common health problem, with a large potential for primary prevention. Health utilities (HU) reflect which proportion of their expected remaining life time individuals would hypothetically trade to be alleviated of a health condition of interest. A value of 0 means "prefer to die immediately", a value of 1 means "not willing to trade any life time". The aim of this cross-sectional study was to assess HU for LBP patients and for healthy participants and to examine whether HU for LBP are useful indicators to substantiate preventive and therapeutic decision making...
2017: Journal of Occupational Medicine and Toxicology
https://www.readbyqxmd.com/read/28878572/dabigatran-reversal-with-idarucizumab-in-a-patient-undergoing-heart-transplantation-first-european-report
#6
António Tralhão, Carlos Aguiar, Jorge Ferreira, Maria José Rebocho, Emília Santos, Dinis Martins, José Pedro Neves
BACKGROUND: Dabigatran is a direct thrombin inhibitor with a favorable effectiveness and safety profile when compared to vitamin K antagonists, both in randomized trials and real world registries of atrial fibrillation patients. Yet, physicians' fear of high bleeding risk scenarios in daily clinical practice still precludes a more widespread use of oral anticoagulation. We hereby report a successful case of dabigatran reversal with the novel monoclonal antibody fragment idarucizumab in a patient undergoing heart transplantation...
2017: Thrombosis Journal
https://www.readbyqxmd.com/read/28860390/contemporary-acetabular-fracture-surgery-treading-water-or-swimming-upstream
#7
REVIEW
M Rickman, V D Varghese
In the time since Letournel popularised the surgical treatment of acetabular fractures, more than 25 years ago, there have been many changes within the field, related to patients, surgical technique, implants and post-operative care. However, the long-term outcomes appear largely unchanged. Does this represent stasis or have the advances been mitigated by other negative factors? In this article we have attempted to document the recent changes within the surgery of patients with a fracture involving the acetabulum, outline contemporary management, and identify the major problem areas where further research is most needed...
September 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28809463/dose-escalated-radiation-therapy-is-associated-with-better-overall-survival-in-patients-with-bone-metastases-from-solid-tumors-a-propensity-score-matched-study
#8
Yung-Chih Chou, Chien-Yu Lin, Ping-Ching Pai, Chen-Kan Tseng, Cheng-En Hsieh, Kai-Ping Chang, Cheng-Lung Hsu, Chun-Ta Liao, Chun-Chieh Wang, Shy-Chyi Chin, Tzu-Chen Yen, Tsung-Ying Ho, Ji-Hong Hong, Kin-Fong Lei, Joseph Tung-Chieh Chang, Ngan-Ming Tsang
We aimed to compare the overall survival (OS) of patients with bone metastases (BM) from solid tumors after standard-dose radiotherapy ([RT]; 30 Gy administered in 10 fractions; EQD2Gy  = 32.5 Gy) and dose-escalated RT (EQD2Gy  > 32.5 Gy). We retrospectively reviewed the clinical charts of 1795 patients (median age, 62.3 years; age range, 18-96 years) with BM from solid tumors who were referred for RT to our institute between 2000 and 2013. These patients were assigned to the standard-dose (n = 1125; 63%) and dose-escalated (n = 670; 37%) RT groups...
August 15, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28797252/evaluation-of-community-based-continuous-distribution-of-long-lasting-insecticide-treated-nets-in-toamasina-ii-district-madagascar
#9
Celine Zegers de Beyl, Albert Kilian, Andrea Brown, Mohamad Sy-Ar, Richmond Ato Selby, Felicien Randriamanantenasoa, Jocelyn Ranaivosoa, Sixte Zigirumugabe, Lilia Gerberg, Megan Fotheringham, Matthew Lynch, Hannah Koenker
BACKGROUND: Continuous distribution of insecticide-treated nets (ITNs) is thought to be an effective mechanism to maintain ITN ownership and access between or in the absence of mass campaigns, but evidence is limited. A community-based ITN distribution pilot was implemented and evaluated in Toamasina II District, Madagascar, to assess this new channel for continuous ITN distribution. METHODS: Beginning 9 months after the December 2012 mass campaign, a community-based distribution pilot ran for an additional 9 months, from September 2013 to June 2014...
August 10, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28772611/effect-of-solidification-behavior-on-microstructures-and-mechanical-properties-of-ni-cr-fe-superalloy-investment-casting
#10
Maodong Kang, Jun Wang, Haiyan Gao, Yanfeng Han, Guoxiang Wang, Shuxian He
The effect of solidification behavior on the microstructures and mechanical properties of Ni-Cr-Fe superalloy investment casting is given. Metallographic and image analysis have been used to quantitatively examine the microstructures' evolution. For the parts with the thickness of 3 mm and 24 mm, the volume fraction and maximum equivalent radius of the Laves phase increases from 0.3% to 1.2%, from 11.7 μm to 23.4 μm, respectively. Meanwhile, the volume fraction and maximum equivalent radius of carbides increase from 0...
March 1, 2017: Materials
https://www.readbyqxmd.com/read/28771000/from-metal-organic-framework-to-porous-carbon-polyhedron-toward-highly-reversible-lithium-storage
#11
Hai-Jun Peng, Gui-Xia Hao, Zhao-Hua Chu, Ying-Lin Cui, Xiao-Ming Lin, Yue-Peng Cai
By application of a newly designed T-shaped ligand 5-(4-pyridin-4-yl-benzoylamino)isophthalic acid (H2PBAI) to assemble with Zn(II) ions under solvothermal conditions, a novel porous polyhedral metal-organic framework (Zn-PBAI) with pcu topology has been obtained. When treated as a precursor by annealing of Zn-PBAI at various temperatures, porous carbon polyhedra (PCP) were prepared and tested as an anode material for lithium-ion batteries. The results show that PCP carbonized at 1000 °C (PCP-1000) manifest the highest reversible specific capacity of about 1125 mAh g(-1) at a current of 500 mA g(-1) after 200 cycles, which is supposed to benefit from the large accessible specific area and high electric conductivity...
August 3, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28762034/transcriptome-profiling-analysis-of-differentially-expressed-mrnas-and-lncrnas-in-hepg2-cells-treated-with-peptide-9r-p201
#12
Wenrong Liu, Ruofan Ding, Yiming Zhang, Canquan Mao, Ran Kang, Junhua Meng, Qingqing Huang, Lili Xiong, Zhiyun Guo
OBJECTIVE: To characterize the transcriptome profile of hepatocellular carcinoma (HCC) HepG2 cells treated with peptide 9R-P201 for further functional verification and HCC drug development. RESULTS: 1557 mRNAs (1125 upregulated and 432 downregulated) and 881 lncRNAs (640 upregulated and 241 downregulated) with significant differential expression were identified using RNA-seq. The qRT-PCR results showed that the differential expression of several mRNAs and lncRNAs coincided with the RNA-seq results...
July 31, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28729407/long-term-stroke-risk-prediction-in-patients-with-atrial-fibrillation-comparison-of-the-abc-stroke-and-cha2ds2-vasc-scores
#13
José Miguel Rivera-Caravaca, Vanessa Roldán, María Asunción Esteve-Pastor, Mariano Valdés, Vicente Vicente, Gregory Y H Lip, Francisco Marín
BACKGROUND: The ABC-stroke score (age, biomarkers [N-terminal fragment B-type natriuretic peptide, high-sensitivity troponin], and clinical history [prior stroke/transient ischemic attack]) was proposed to predict stroke in atrial fibrillation (AF). This score was derived/validated in 2 clinical trial cohorts in which patients with AF were highly selected and carefully followed-up. However, the median follow-up was 1.9 years in the trial cohort; therefore, its long-term predictive performance remains uncertain...
July 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28715148/lineage-specific-epitope-profiles-for-hpai-h5-pre-pandemic-vaccine-selection-and-evaluation
#14
Xueting Qiu, Venkata R Duvvuri, Jonathan B Gubbay, Richard J Webby, Ghazi Kayali, Justin Bahl
BACKGROUND: Multiple highly pathogenic avian influenza (HPAI) H5 viruses continue to co-circulate. This has complicated pandemic preparedness and confounded effective vaccine candidate selection and evaluation. OBJECTIVES: In this study, we aimed to predict and map the diversity of CD8+ T-cell epitopes among H5 hemagglutinin (HA) gene lineages to estimate CD8+ T-cell immunity in humans induced by vaccine candidates. METHODS: A dataset consisting of 1125 H5 HA sequences collected between 1996 and 2017 from avian and humans was assembled for phylogenetic and lineage-specific epitope analyses...
July 17, 2017: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/28713606/autologous-concentrated-bone-marrow-grafting-for-the-treatment-of-osteonecrosis-of-the-humeral-head-a-report-of-five-shoulders-in-four-cases
#15
Takeshi Makihara, Tomokazu Yoshioka, Hisashi Sugaya, Masashi Yamazaki, Hajime Mishima
Five shoulders in four patients affected by advanced osteonecrosis of the humeral head were treated with autologous concentrated bone marrow grafting. Bone marrow sample was aspirated from the iliac crests, concentrated by a centrifugation technique, and injected into the necrotic site. The shoulders were evaluated radiologically with X-ray scoring and clinically with measurement of range of motion and pain score (visual analogue scale, VAS). The mean follow-up period was 49.4 (range, 24-73) months. The concentration ratio of nucleated cells was calculated and the number of transplanted mesenchymal stem cells (MSC) was estimated by a colony-forming assay...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28707175/acculturation-and-syndemic-risk-longitudinal-evaluation-of-risk-factors-among-pregnant-latina-adolescents-in-new-york-city
#16
Isabel Martinez, Trace S Kershaw, Danya Keene, Rafael Perez-Escamilla, Jessica B Lewis, Jonathan N Tobin, Jeannette R Ickovics
BACKGROUND: Syndemics are co-occurring epidemics that synergistically contribute to specific risks or health outcomes. Although there is substantial evidence demonstrating their existence, little is known about their change over time in adolescents. PURPOSE: The objectives of this paper were to identify longitudinal changes in a syndemic of substance use, intimate partner violence, and depression and determine whether immigration/cultural factors moderate this syndemic over time...
July 13, 2017: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/28695184/the-stability-of-dual-taper-modular-hip-implants-a-biomechanical-analysis-examining-the-effect-of-impact-location-on-component-stability
#17
Nicholas B Frisch, Jonathan R Lynch, Richard F Banglmaier, Craig D Silverton
BACKGROUND: The purpose of this study was to investigate the stability of dual-taper modular implants following impaction forces delivered at varying locations as measured by the distraction forces required to disassemble the components. METHODS: Distraction of the head-neck and neck-stem (NS) tapers of dual-taper modular implants with 0°, 8°, and 15° neck angles were measured utilizing a custom-made distraction fixture attached to a servohydraulic materials test machine...
June 2017: Arthroplasty Today
https://www.readbyqxmd.com/read/28687081/potential-mediators-between-fibromyalgia-and-c-reactive-protein-results-from-a-large-u-s-community-survey
#18
Termeh Feinberg, Usha Sambamoorthi, Christa Lilly, Kim Karen Innes
BACKGROUND: Fibromyalgia, a potentially debilitating chronic pain syndrome of unknown etiology, may be characterized by inflammation. In this study, we investigated the relation of FMS to serum C-reactive protein (CRP) in a large population of adults (18+) and investigated the influence of other factors on this relationship, including BMI, comorbidities, as well as mood and sleep disturbance. METHODS: Participants were 52,535 Ohio Valley residents (Fibromyalgia n = 1125)...
July 7, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28675207/spectrally-resolved-third-harmonic-generation-and-the-fundamental-role-of-o-hcl-hydrogen-bonding-in-oh-td-cobalt-ii-tetraphenylmethane-based-coordination-polymers
#19
J K Zaręba, J Janczak, M Samoć, M Nyk
The reaction of a phosphonate-diester tetraphenylmethane-based tecton, tetrakis[4-(diethoxyphosphoryl)phenyl]methane, (L) with cobalt(ii) chloride afforded a centrosymmetric coordination polymer (CP), [L·2Co(H2O)4(2+)·2CoCl4(2-)]n, 2-Cl, possessing simultaneously octahedral (Oh) and tetrahedral (Td) metal centers. This material served as a model compound for the demonstration of factors influencing the spectral dependence of one of the nonlinear optical (NLO) phenomena, the third-harmonic generation (THG)...
July 25, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28673504/additional-improvements-in-clinical-response-from-adjuvant-biologic-response-modifiers-in-adults-with-moderate-to-severe-systemic-lupus-erythematosus-despite-immunosuppressive-agents-a-systematic-review-and-meta-analysis
#20
REVIEW
Tatyana A Shamliyan, Paula Dospinescu
PURPOSE: The role of biologic disease-modifying drugs in patients with systemic lupus erythematosus (SLE) remains controversial. METHODS: Following systematic review and meta-analysis protocol, we searched PubMed, EMBASE, Cochrane Library, and ClinicalTrials.gov in January 2017 to identify all studies of people with SLE treated with biologic response modifiers. We performed direct frequentist random effects meta-analyses, calculated pooled relative risk and number needed to treat to achieve an outcome in 1 patient (NNT) as reciprocal to statistically significant absolute risk difference, and graded the quality of evidence by using the Grading of Recommendations Assessment, Development, and Evaluation criteria...
July 2017: Clinical Therapeutics
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