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ovarian germ cell tumors

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https://www.readbyqxmd.com/read/29768344/synchronous-adrenocortical-carcinoma-and-ovarian-malignant-mixed-germ-cell-tumor-a-case-report-and-literature-review
#1
Ying He, Lian Xu, Qingli Li, Min Feng, Wei Wang
RATIONALE: Adrenocortical carcinoma (ACC) is an endocrine malignancy with poor prognosis, which commonly arises in a sporadic manner, but may also become a part of a familial syndrome. ACC rarely arises simultaneously with other malignant tumors. PATIENT CONCERNS: We report a case of a 29-year-old woman with ACC synchronously followed by an ovarian malignant mixed germ cell tumor. We describe the clinical, histopathological, and immunohistochemical findings and review the English literatures...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29765511/immunohistochemical-analysis-of-rhamm-expression-in-normal-and-neoplastic-human-tissues-a-cell-cycle-protein-with-distinctive-expression-in-mitotic-cells-and-testicular-germ-cells
#2
Yao-Tseng Chen, Zhengming Chen, Yi-Chieh Nancy Du
Expression of Receptor for Hyaluronic Acid Mediated Motility (RHAMM) increases cellular motility and RHAMM overexpression promotes invasive phenotype and metastasis of cancer cells. RHAMM has been suggested as a biomarker for poor prognosis in several tumor types, including lung, breast, colorectal, gastric, pancreatic ductal, and ovarian cancers. RNA studies showed restricted RHAMM expression in normal tissues, but its protein expression data in tissues were limited. In light of its potential as a prognostic marker and a therapeutic target, we performed immunohistochemical analysis to systematically characterize RHAMM expression in normal and neoplastic human tissues...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29753846/role-of-hnf1%C3%AE-in-the-differential-diagnosis-from-other-germ-cell-tumors
#3
Anne-Laure Rougemont, Jean-Christophe Tille
Identification of the yolk sac tumor (YST) component in germ cell tumors (GCT) may prove challenging, and highly sensitive and specific immunohistochemical markers are still lacking. Preliminary data from the literature suggest that HNF1β may represent a sensitive marker of YST. The specificity of HNF1β has not been addressed in GCT. A cohort of 49 YST specimens from 45 patients was designed, occurring either as pure tumors, or as a component of a mixed GCT. Immunohistochemistry was conducted on whole tumor sections using HNF1β...
May 10, 2018: Human Pathology
https://www.readbyqxmd.com/read/29731802/pseudopapillary-and-macrofollicular-microscopic-growth-patterns-in-an-advanced-stage-ovarian-dysgerminoma-a-case-report
#4
Fatemeh Nili, Niusha Nobari, Alireza Abdollahi
Dysgerminoma is one of the two most common types of ovarian germ cell tumors. Providing accurate pathologic diagnosis and treatment planning, the prognosis is good even in advanced stages. Pathologic diagnosis is generally straightforward. In microscopic examination, the usual known growth patterns in tumor cells are solid, trabecular, insular and rarely pseudoglandular. In this paper, we reported an advanced ovarian dysgerminoma with different microscopic patterns of growth, including pseudopapillary and macrofollicular structures, in an 18-year-old woman...
2018: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/29673667/the-role-of-preoperative-serum-cancer-antigen-125-in-malignant-ovarian-germ-cell-tumors
#5
Ju-Hyun Kim, Jeong-Yeol Park, Jong-Hyeok Kim, Yong-Man Kim, Young-Tak Kim, Joo-Hyun Nam
OBJECTIVE: To determine the role of preoperative serum cancer antigen 125 (CA 125) in malignant ovarian germ cell tumors (MOGCTs). MATERIALS AND METHODS: Using information from medical databases of Asan Medical Center (Seoul, Korea), we investigated 161 patients with histologically diagnosed MOGCTs and whose preoperative serum CA 125 had been checked. We determined the optimal cutoff value of CA 125 as > 249.5 U/mL in MOGCTs using a receiver operating characteristic curve...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29580145/ovarian-dysgerminoma-in-pregnancy-a-case-report-and-literature-review
#6
Yuanyuan Chen, Ying Luo, Cha Han, Wenyan Tian, Wen Yang, Yingmei Wang, Fengxia Xue
BACKGROUND: Dysgerminoma is an uncommon malignant tumor arising from the germ cells of the ovary. Its association with pregnancy is extremely rare; the incidence is about 0.2-1 per 100,000 pregnancies. Because of its infrequency, there are few recommendations regarding its management in pregnancy; therefore, it is important to discuss and summarize the treatment strategy. CASE: We presented a case of a 23-year-old pregnant woman with a large dysgerminoma originated from the right ovary, which had the unusual coincidence of being associated with an abdominal desmoid tumor simultaneously...
March 26, 2018: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29531580/histopathological-pattern-and-age-distribution-of-malignant-ovarian-tumor-among-sudanese-ladies
#7
Sumeya A Kheiri, Abdelillah Kunna, Ali Yousif Babiker, Sultan A Alsuhaibani, Rami Yousif Ahmed, Mohamed Alkhatim Alsammani
INTRODUCTION: Ovarian cancer is the cause of a high case-fatality ratio, and most of the cases are diagnosed in late stages. OBJECTIVES: To determine the histopathological types, age distribution, and ovarian tumour stages among diagnosed with ovarian cancer at Al - Amal Tower a multi-referral polyclinic of Radiology & Isotope Center Khartoum (RICK), Sudan. METHODS: All histopathology reports patients' case from January to June 2015 were reviewed...
February 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29509324/erratum-pashankar-f-hale-jp-dang-h-et-al-is-adjuvant-chemotherapy-indicated-in-ovarian-immature-teratomas-a-combined-data-analysis-from-the-malignant-germ-cell-tumor-international-collaborative-cancer-2016-122-230-237
#8
https://www.readbyqxmd.com/read/29453163/incidentally-discovered-persistent-m%C3%A3-llerian-duct-syndrome-in-a-45-year-old-male-presenting-with-germ-cell-tumor-and-bilateral-cryptorchidism-a-rare-case-report-and-review-of-the-literature
#9
Turki Z Al Harbi, Kareem Ayman Azzam, Ayman Azzam, Tarek Amin, Nasir Bakshi
INTRODUCTION: Persistent Müllerian Duct Syndrome (PMDS) is a rare sexual disease. It is characterized by the presence of female reproductive structures such as uterus, cervix, fallopian tubes and upper part of vagina in a normal genotypically and phenotypically male. The diagnosis is usually incidental since the patients will present with normal external genitalia and secondary sexual characteristics. Imaging techniques such as magnetic resonance imaging (MRI), computed tomography (CT) scan, or ultrasound (US) could help in the diagnosis...
2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29450608/imaging-findings-of-ovarian-dysgerminoma-with-emphasis-on-multiplicity-and-vascular-architecture-pathogenic-implications
#10
Takahiro Tsuboyama, Yumiko Hori, Masatoshi Hori, Hiromitsu Onishi, Mitsuaki Tatsumi, Makoto Sakane, Takashi Ota, Noriyuki Tomiyama
We report the imaging findings of three ovarian dysgerminomas that coexisted with other germ cell tumors or gonadoblastomas, focusing on the distribution of tumor nests and vascular architecture, which might provide information about the pathogenesis of dysgerminomas. In a 14-year-old female with dysgerminoma and coexisting gonadoblastomas, contrast-enhanced magnetic resonance imaging (MRI) demonstrated a solid mass in the right ovary, which presented as hyperintense lobules on diffusion-weighted imaging separated by fibrovascular septa...
February 15, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29433744/chemotherapy-induced-response-of-liver-hemangiomas-in-a-patient-with-a-germ-cell-tumor-a-case-report
#11
N Arévalo, R Méndez, A Manzano
Liver hemangiomas are the most common benign primary tumors of the liver. Due to their high prevalence, incidental finding of hemangiomas during radiological workup of oncologic patients is not uncommon. We present the case of a patient diagnosed of an ovarian immature teratoma and hepatic lesions with typical radiological appearance of hemangiomas that decreased in size during adjuvant chemotherapy with BEP regimen (cisplatin, etoposide and bleomycin). Chemotherapy-induced shrinkage of hepatic hemangiomas can mimic the response of liver metastases to chemotherapy and may induce erroneous interpretations...
February 9, 2018: Radiología
https://www.readbyqxmd.com/read/29399351/extremely-large-epithelial-ovarian-cancer-associated-with-pregnancy-a-case-report
#12
Viktoria Husz, Dorottya Bus, Gyorgy Vajda
Ovarian malignancies are rare in pregnancy; however, the incidence of abnormal adnexal masses diagnosed during pregnancy is increasing. The most common masses are ovarian cysts, and only 3-6% of those are malignant. The majority of ovarian masses are diagnosed at an early stage by routine ultrasound examinations. Malignant germ cell tumors are the most common ovarian malignancies associated with pregnancy, while the incidence of epithelial ovarian cancer is only 1:12,000-1:50,000 of pregnancies. The diagnosis and management of ovarian cancer during pregnancy remain unclear due to the rare occurrence and scant data on this condition...
January 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29397916/-fertility-preservation-contraception-and-menopause-hormone-therapy-in-women-treated-for-rare-ovarian-tumors-guidelines-from-the-french-national-network-dedicated-to-rare-gynaecological-cancer
#13
Christine Rousset-Jablonski, Fréderic Selle, Elodie Adda-Herzog, François Planchamp, Lise Selleret, Christophe Pomel, Nathalie Chabbert-Buffet, Emile Daraï, Patricia Pautier, Florence Trémollières, Frederic Guyon, Roman Rouzier, Valérie Laurence, Nicolas Chopin, Cécile Faure-Conter, Enrica Bentivegna, Marie-Cécile Vacher-Lavenu, Catherine Lhomme, Anne Floquet, Isabelle Treilleux, Fabrice Lecuru, Sébastien Gouy, Elsa Kalbacher, Catherine Genestie, Thibault de la Motte Rouge, Gwenael Ferron, Mojgan Devouassoux-Shisheboran, Jean-Emmanuel Kurtz, Moise Namer, Florence Joly, Eric Pujade-Lauraine, Michael Grynberg, Denis Querleu, Philippe Morice, Anne Gompel, Isabelle Ray-Coquard
INTRODUCTION: Rare ovarian tumors include complex borderline ovarian tumors, sex-cord tumors, germ cell tumors, and rare epithelial tumors. Indications and modalities of fertility preservation, infertility management and contraindications for hormonal contraception or menopause hormone therapy are frequent issues in clinical practice. A panel of experts from the French national network dedicated to rare gynaecological cancers, and of experts in reproductive medicine and gynaecology have worked on guidelines about fertility preservation, contraception and menopause hormone therapy in women treated for ovarian rare tumors...
March 2018: Bulletin du Cancer
https://www.readbyqxmd.com/read/29286555/gonadal-dysgenesis-is-associated-with-worse-outcomes-in-patients-with-ovarian-nondysgerminomatous-tumors-a-report-of-the-children-s-oncology-group-agct-0132-study
#14
Bryan J Dicken, Deborah F Billmire, Mark Krailo, Caihong Xia, Furqan Shaikh, John W Cullen, Thomas A Olson, Farzana Pashankar, Marcio H Malogolowkin, James F Amatruda, Frederick J Rescorla, Rachel A Egler, Jonathan H Ross, Carlos Rodriguez-Galindo, A Lindsay Frazier
PURPOSE: In this report, we characterize the timing and behavior of malignant ovarian germ cell tumors (GCTs) in pediatric patients with dysgenetic gonads compared to those with normal gonadal development. PATIENTS AND METHODS: Patients from the Children's Oncology Group AGCT0132 with malignant ovarian GCTs were included. Within this population, we sought to identify patients with gonadoblastoma, streak ovaries, or other evidence of gonadal dysgenesis (GD). Patients with malignant GCTs containing one or more of the following histologies-yolk sac tumor, embryonal carcinoma, or choriocarcinoma-were included...
April 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29248013/fertility-sparing-surgery-in-advanced-stage-malignant-ovarian-germ-cell-tumor-a-case-report
#15
Montassar Ghalleb, Hatem Bouzaiene, Skander Slim, Achraf Hadiji, Monia Hechiche, Jamel Ben Hassouna, Khaled Rahal
BACKGROUND: Malignant ovarian germ cell tumor is a rare type of disease, which generally has a good prognosis due to the high chemosensitivity of this type of tumor. Fertility preservation is an important issue because malignant ovarian germ cell tumor commonly affects young women. Although conservation is the standard for early stage, it becomes more debatable as the disease progresses to more advanced stages. AIM: Report the case of a patient with an International Federation of Gynecology and Obstetrics Stage IIIc malignant ovarian germ cell tumor, who had conservative surgery and chemotherapy with a good fertility outcome...
December 17, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29240033/paraneoplastic-cytopenia-in-ovarian-germ-cell-tumor-a-novel-presentation
#16
Federico Mercolini, Laura Battisti, Laura Sainati, Gianni Bisogno
We report on the case of a 12-year-old girl, who presented with an ovarian germ cell tumor and cytopenia (anemia and thrombocytopenia) as an associated paraneoplastic syndrome, which gradually regressed after the tumor's removal. This report adds to the previously described paraneoplastic syndromes potentially associated with ovarian germ cell tumor.
December 12, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29227858/bilateral-ovarian-angiosarcoma-arising-from-the-mature-cystic-teratomas-a-case-report-and-review-of-the-literature
#17
Erik Kudela, Marcela Nachajova, Kamil Biringer, Pavol Slavik, Lukas Plank, Jan Danko
INTRODUCTION: Ovarian teratomas undergo the malignant transformation in 0.2-2% of cases. The behavior of malignancies in mature cystic teratomas (MCT) is determined by their phenotype and not their derivation from germ cells. We can recognize pure angiosarcomas or as a part of other tumors like malignant mixed Mullerian tumors and adenosarcomas. PRESENTATION OF CASE: We present the first case of bilateral ovarian angiosarcoma arising from the mature teratomas. Due to widespread disease, we performed limited surgical procedure consisting of bilateral adnexectomy and omentectomy...
2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29227254/-modern-approaches-to-diagnosis-and-treatment-of-tumors-of-female-genitals-of-children-and-adolescents-review
#18
A Solopova, A Makatsaryia, O Yakovleva, V Moskvicheva
The article discusses the features of epidemiology, morphology, clinical course and modern principles of diagnostics and treatment of tumors of female genitals of children and adolescents. Special attention is paid to ovarian germ cell tumors. The use of immunohistochemical and tumor markers enables the differential diagnosis among malignant ovarian germ cell tumors. Nowadays surgical methods, chemotherapy and radiation therapy are applied in treatment of tumors of female genitals. The main standard of surgical operation of ovarian tumors is removal of appendages on the side of the affection...
November 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29204510/ovarian-yolk-sac-tumor-coexisting-with-epithelial-ovarian-cancer-an-aggressive-rare-entity
#19
Patrícia Taranto, Filomena M Carvalho, Sergio Roithmann, Fernando C Maluf
Yolk sac tumor (YST) is the second most common subtype of ovarian germ cell tumors. It usually occurs in the second and third decades of life and is rare in postmenopausal women. In postmenopausal women, YST is commonly an aggressive tumor and can present as a pure germ cell component or as a mixed component with other germ cell or epithelial components. The recognition of this histological subtype is important not only for differential diagnosis but also for determining prognosis and treatment decisions. In this case report, we describe a 61-year-old woman with YST coexisting with epithelial carcinoma focusing on the efficacy of systemic therapies...
November 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29198336/fertility-management-for-malignant-ovarian-germ-cell-tumors-patients
#20
REVIEW
Chiara Di Tucci, Assunta Casorelli, Elisa Morrocchi, Innocenza Palaia, Ludovico Muzii, Pierluigi Benedetti Panici
Malignant Germ Cell Tumors have primarily affecting adolescents and young adults. In advanced disease, greater than 70% of patients can be cured with standard chemotherapy regimens and fertility-sparing surgery appears to be safe with excellent survival after long-term follow-up. Due to their rarity, follow up and fertility management is largely based on trials of epithelial ovarian cancer or on few small studies. We report a review of the literature studies about the assessment, the monitoring and the treatment of fertility for Malignant Germ Cell Tumors as pratical guidelines for management of fertility in these patients...
December 2017: Critical Reviews in Oncology/hematology
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