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https://www.readbyqxmd.com/read/27891282/a-teenage-girl-with-acute-dyspnea-and-hypoxemia-during-red-blood-cell-transfusion
#1
U Pandee, P Tanpowpong, P Thongpo
Transfusion-related acute lung injury (TRALI) can cause morbidity and mortality. We present the case of teenager who developed dyspnea and hypoxemia few hours after red cell transfusion. After being admitted for close monitoring and oxygen therapy, her symptoms spontaneously resolved. Message: dyspnea during red cell transfusion should raise the suspicion of TRALI.
2016: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/27829169/slc44a2-single-nucleotide-polymorphisms-isoforms-and-expression-association-with-severity-of-meniere-s-disease
#2
Thankam S Nair, Pavan K Kommareddi, Maria M Galano, Danielle M Miller, Bala Naveen Kakaraparthi, Steven A Telian, H Alex Arts, Hussam El-Kashlan, Alyse Kilijanczyk, Amy Anne D Lassig, Martin P Graham, Susan G Fisher, Stefan W Stoll, Rajan P Nair, James T Elder, Thomas E Carey
SLC44A2 was discovered as the target of an antibody that causes hearing loss. Knockout mice develop age related hearing loss, loss of sensory cells and spiral ganglion neurons. SLC44A2 has polymorphic sites implicated in human disease. Transfusion related acute lung injury (TRALI) is linked to rs2288904 and genome wide association studies link rs2288904 and rs9797861 to venous thromboembolism (VTE), coronary artery disease and stroke. Here we report linkage disequilibrium of rs2288904 with rs3087969 and the association of these SLC44A2 SNPs with Meniere's disease severity...
November 6, 2016: Genomics
https://www.readbyqxmd.com/read/27793007/elevation-of-c-reactive-protein-levels-in-patients-with-transfusion-related-acute-lung-injury
#3
Rick Kapur, Michael Kim, Matthew T Rondina, Leendert Porcelijn, John W Semple
Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related fatalities and is characterized by the onset of acute respiratory distress within six hours following blood transfusion. In most cases, donor antibodies are suggested to be involved, however, the pathogenesis is poorly understood. A two-hit model is generally assumed to underlie TRALI pathogenesis where the first hit consists of a patient predisposing factor such as inflammation and the second hit is due to donor antibodies present in the transfused blood...
October 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27667662/antibodies-to-major-histocompatibility-complex-class-ii-antigens-directly-prime-neutrophils-and-cause-acute-lung-injury-in-a-two-event-in-vivo-rat-model
#4
Marguerite R Kelher, Anirban Banerjee, Fabia Gamboni, Cameron Anderson, Christopher C Silliman
BACKGROUND: Transfusion-related acute lung injury (TRALI) is a significant cause of mortality, especially after transfusions containing antibodies to major histocompatibility complex (MHC) class II antigens. We hypothesize that a first event induces both 1) polymorphonuclear neutrophils (PMNs) to express MHC class II antigens, and 2) activation of the pulmonary endothelium, leading to PMN sequestration, so that the infusion of specific MHC class II antibodies to these antigens causes PMN-mediated acute lung injury (ALI)...
September 25, 2016: Transfusion
https://www.readbyqxmd.com/read/27651980/spontaneous-rectus-sheath-hematoma-in-pregnancy-complicated-by-the-development-of-transfusion-related-acute-lung-injury-a-case-report-and-review-of-the-literature
#5
Jennifer Gibbs, Firas Bridges, Kiran Trivedi, John Vullo
BACKGROUND: Rectus sheath hematoma (RSH) represents a rare, but serious cause of abdominal pain. CASE: Here we discuss the case of a healthy multigravida female who presented at 28 weeks gestation with spontaneous RSH. Conservative management with multiple blood transfusions led to the development of transfusion related acute lung injury (TRALI) and intensive care unit admission. She was managed with noninvasive ventilatory support, gradually improved, and was weaned of ventilation...
July 2016: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/27531930/lysopcs-induce-hck-and-pkc%C3%AE-mediated-activation-of-pkc%C3%AE-causing-p47phox-phosphorylation-and-membrane-translocation-in-neutrophils
#6
Marguerite R Kelher, Nathan J D McLaughlin, Anirban Banerjee, David J Elzi, Fabia Gamboni, Samina Y Khan, Xianzhong Meng, Sanchayita Mitra, Christopher C Silliman
Lysophosphatidylcholines (lysoPCs) are effective polymorphonuclear neutrophil (PMN) priming agents implicated in transfusion-related acute lung injury (TRALI). LysoPCs cause ligation of the G2A receptor, cytosolic Ca(2+) flux, and activation of Hck. We hypothesize that lysoPCs induce Hck-dependent activation of protein kinase C (PKC), resulting in phosphorylation and membrane translocation of 47 kDa phagocyte oxidase protein (p47(phox)). PMNs, human or murine, were primed with lysoPCs and were smeared onto slides and examined by digital microscopy or separated into subcellular fractions or whole-cell lysates...
August 16, 2016: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/27499223/immunological-complications-of-blood-transfusions
#7
Anneke Brand
Most adverse blood transfusion (BT) events are immune-mediated and in the majority of severe reactions antibodies can be identified as causal factors. Alloimmunization not only causes symptomatic reactions, transfused cells can also be (silently) destroyed. Immunization by BT can contribute to hemolytic disease of the newborn as well as to allograft rejection after transplantation. Reversely, pregnancy and transplantation may evoke immunity hampering transfusion therapy. Besides causing mortality and morbidity, alloimmunization has a huge economic impact...
July 2016: La Presse Médicale
https://www.readbyqxmd.com/read/27306135/transfusion-related-acute-lung-injury-in-a-young-woman-with-ectopic-pregnancy-case-report-and-literature-review
#8
Krzysztof Jaworski, Krystyna Maślanka, Artur Jakimiuk, Patrycja Łopacz, Paweł Panin, Dariusz A Kosior
BACKGROUND: Transfusion-related acute lung injury (TRALI) is a major cause of death associated with transfusion. Nevertheless it is still misdiagnosed and underreported. We present a case of this serious complication in order to make it more familiar to clinicians and indicate proper medical management, which is significant not only for the patients presenting TRALI symptoms but also for future recipients of blood components. CASE PRESENTATION: A 32-year-old white woman with in-vitro fertilization in anamnesis was admitted to Department of Obstetrics and Gynecology because of abdominal pain...
2016: Ginekologia Polska
https://www.readbyqxmd.com/read/26991993/underdiagnosing-of-antibody-mediated-transfusion-related-acute-lung-injury-evaluation-of-cellular-based-versus-bead-based-techniques
#9
D van Stein, E A M Beckers, A L Peters, L Porcelijn, R A Middelburg, N M Lardy, D J van Rhenen, A P J Vlaar
BACKGROUND AND OBJECTIVES: Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related mortality. To support the diagnosis of antibody-mediated TRALI, HLA and HNA antibodies are tested in involved blood donors. Identification of antibody positive donors is important as exclusion of these donors is part of preventative strategies against TRALI. We compared cellular-based versus bead-based techniques for diagnosis of antibody-mediated TRALI. MATERIALS AND METHODS: All reported TRALI cases in the Netherlands during a 5-year period were evaluated...
July 2016: Vox Sanguinis
https://www.readbyqxmd.com/read/26815270/resuscitation-and-monitoring-in-gastrointestinal-bleeding
#10
Yusuf Alper Kılıç, Ali Konan, Volkan Kaynaroğlu
INTRODUCTION: Gastrointestinal bleeding is a common life-threatening problem, causing significant mortality, costs and resource allocation. Its management requires a dynamic multidisciplinary approach that directs diagnostic and therapeutic priorities appropriately. MATERIALS AND METHODS: Articles published within the past 15 years, related to gastrointestinal bleeding, were reviewed through MEDLINE search, in addition to current guidelines and standards. RESULTS: Decisions of ICU admission and blood transfusion must be individualized based on the extent of bleeding, hemodynamic profile and comorbidities of the patient and the risk of rebleeding...
August 2011: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/26689071/-successful-extracorporeal-membrane-oxygenation-for-a-patient-with-nearly-fatal-hypoxemia-induced-by-transfusion-related-acute-lung-injury
#11
Ayako Honda, Masato Morita, Akiko Taniguchi, Akihiko Tabuchi, Sadahiro Kubo
Transfusion-related acute lung injury (TRALI) is known to be the leading cause of transfusion-related mortality. A nearly fatal case of postoperative TRALI, successfully managed with extracorporeal membrane oxygenation (ECMO), is reported. The patient was a 70-year-old woman for whom laparoscopic nephrectomy was planned. She received several units of packed red blood cells and fresh-frozen plasma (FFP) intraoperatively due to massive bleeding. At the end of the operation, her PaO2/FIO2 ratio was 504, and she was extubated...
November 2015: Masui. the Japanese Journal of Anesthesiology
https://www.readbyqxmd.com/read/26633306/leukoreduction-for-the-prevention-of-adverse-reactions-from-allogeneic-blood-transfusion
#12
REVIEW
Daniel Simancas-Racines, Dimelza Osorio, Arturo J Martí-Carvajal, Ingrid Arevalo-Rodriguez
BACKGROUND: A blood transfusion is an acute intervention, implemented to solve life and health-threatening conditions on a short-term basis. However, blood transfusions have adverse events, some of them potentially related to immune modulation or to a direct transmission of infectious agents (e.g. cytomegalovirus). Leukoreduction is a process in which the white blood cells are intentionally reduced in packed red blood cells (PRBCs) in order to reduce the risk of adverse reactions. The potential benefits of leukoreduced PRBCs in all types of transfused patients for decreasing infectious and non-infectious complications remain unclear...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26605093/cardiac-and-pulmonary-ultrasound-for-diagnosing-trali
#13
J I Alonso-Fernández, J R Prieto-Recio, C García-Bernardo, I García-Saiz, J Rico-Feijoo, C Aldecoa
Unexpected acute respiratory failure after anesthesia is a diagnostic challenge: residual neuromuscular blockade, bronchial hyperresponsiveness, laryngospasm, atelectasis, aspiration pneumonitis, and other more uncommon causes should be taken into account at diagnosis. Lung ultrasound and echocardiography are diagnostic tools that would provide the differential diagnosis. We report a suspected case of a transfusion related acute lung injury (TRALI) following administration of platelets. The usefulness of lung and cardiac ultrasound is discussed to facilitate the challenging diagnosis of the acute early postoperative respiratory failure...
2015: Case Reports in Critical Care
https://www.readbyqxmd.com/read/26593331/genotype-frequency-of-human-neutrophil-antigen-3-polymorphisms-in-the-yi-han-and-tibetan-populations-of-china
#14
Qing Chen, Kshitij Srivastava, Zhong Liu, Jianyu Xiao, Chengyin Huang, Jun Sun, Min Li, Willy Albert Flegel
BACKGROUND: Human neutrophil antigen-3 (HNA-3) alloantibodies can cause fatal transfusion-related acute lung injury (TRALI). Most frequencies of SLC44A2 alleles encoding the HNA-3a/b antigens have been established in Han individuals by polymerase chain reaction with sequence-specific priming (PCR-SSP). We sequenced SLC44A2 gene fragments and determined allele frequencies in three ethnicities of China. STUDY DESIGN AND METHODS: Genomic DNA was extracted from 448 samples of 100 blood donors of Yi ethnicity in Xichang, Liangshan; 248 Han in Nanjing, Jiangsu; and 100 Tibetan in Lhasa, Tibet...
March 2016: Transfusion
https://www.readbyqxmd.com/read/26557816/evaluation-of-risk-minimisation-measures-for-blood-components-based-on-reporting-rates-of-transfusion-transmitted-reactions-1997-2013
#15
Markus B Funk, Margarethe Heiden, Peter Volkers, Annette Lohmann, Brigitte Keller-Stanislawski
BACKGROUND: To assess the impact of safety measures, we compared reporting rates of transfusion-related reactions before and after the implementation of six measures in 1999, 2004, 2006, 2008 and 2009. METHODS: Reporting rates of transfusion-transmitted bacterial infection (TTBI), viral infection (TTVI) and immune-mediated transfusion-related acute lung injury (TRALI) were calculated on the basis of confirmed annual reports and distributed blood components. RESULTS: The introduction of HCV NAT testing caused a significant reduction of HCV reporting rate from 1:0...
July 2015: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/26453659/c-reactive-protein-enhances-murine-antibody-mediated-transfusion-related-acute-lung-injury
#16
Rick Kapur, Michael Kim, Shanjeevan Shanmugabhavananthan, Jonathan Liu, Yuan Li, John W Semple
Transfusion-related acute lung injury (TRALI) is a syndrome of respiratory distress triggered by blood transfusions and is the leading cause of transfusion-related mortality. TRALI has primarily been attributed to passive infusion of HLA and/or human neutrophil antigen antibodies present in transfused blood products, and predisposing factors such as inflammation are known to be important for TRALI initiation. Because the acute-phase protein C-reactive protein (CRP) is highly upregulated during infections and inflammation and can also enhance antibody-mediated responses such as in vitro phagocytosis, respiratory burst, and in vivo thrombocytopenia, we investigated whether CRP affects murine antibody-mediated TRALI induced by the anti-major histocompatibility complex antibody 34-1-2s...
December 17, 2015: Blood
https://www.readbyqxmd.com/read/26397744/accumulation-of-cd62p-during-storage-of-apheresis-platelet-concentrates-and-the-role-of-cd62p-in-transfusion-related-acute-lung-injury
#17
Shan Tong, Haibao Wang, Ting Zhang, Linfeng Chen, Bowei Liu
Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-associated morbidity and mortality. Activated platelets have important roles in TRALI and CD62P was identified to be an important indicator of platelet activation. However, the precise roles of CD62P in TRALI have remained elusive. The present study assessed CD62P accumulation during storage of apheresis platelet concentrates (A‑Plts) and established a mouse model of TRALI to further investigate the roles of CD62P in TRALI. The results showed that the CD62P concentration in A‑Plts was increased with the storage time...
November 2015: Molecular Medicine Reports
https://www.readbyqxmd.com/read/26388439/transfusion-related-alloimmune-neutropenia-with-no-pulmonary-complications-one-donor-five-cases
#18
Barbara Hauck-Dlimi, Renate Ruppel, Robert Zimmermann, Julian Strobel, Angelika Reil, Reinhold Eckstein, Juergen Zingsem
BACKGROUND: Neutrophil alloantibodies are well-known triggers of transfusion-related acute lung injury (TRALI) and also cause immune neutropenia. Alloimmune neutropenia due to transfusion is an isolated phenomenon that is only rarely identified. Its incidence is specified in the literature as being less than one in 10,000 transfused plasma-containing units. We expect that this phenomenon is underreported. STUDY DESIGN AND METHODS: We observed five cases of alloimmune neutropenia with no respiratory complications with only one case initially reported as a suspected transfusion reaction...
January 2016: Transfusion
https://www.readbyqxmd.com/read/26312100/transfusion-related-acute-lung-injured-trali-current-concepts
#19
P Álvarez, R Carrasco, C Romero-Dapueto, R L Castillo
Transfusion-related acute lung injury (TRALI) is a life-threatening intervention that develops within 6 hours of transfusion of one or more units of blood, and is an important cause of morbidity and mortality resulting from transfusion. It is necessary to dismiss other causes of acute lung injury (ALI), like sepsis, acute cardiogenic edema, acute respiratory distress syndrome (ARDS) or bacterial infection. There are two mechanisms that lead to the development of this syndrome: immune-mediated and no immune- mediated TRALI...
2015: Open Respiratory Medicine Journal
https://www.readbyqxmd.com/read/26297289/distinguishing-the-causes-of-pulmonary-infiltrates-in-patients-with-acute-leukemia
#20
Marcio Nucci, Simone A Nouér, Elias Anaissie
Pulmonary infiltrates are commonly observed in patients with acute leukemia (AL), particularly acute myeloid leukemia, who undergo remission induction therapy. The mortality rate is unacceptably high and depends on 3 factors: the host (performance status, comorbidities, and frailty), the etiology of the infiltrates and the type of response to antileukemic therapy. The approach to the diagnosis of pulmonary infiltrates in patients with AL includes a medical history, thorough physical examination, radiologic pattern of the infiltrates (focal vs...
June 2015: Clinical Lymphoma, Myeloma & Leukemia
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