keyword
MENU ▼
Read by QxMD icon Read
search

Emergency simulation

keyword
https://www.readbyqxmd.com/read/29775804/in-silico-study-of-the-active-site-of-helicobacter-pylori-urease-and-its-inhibition-by-hydroxamic-acids
#1
Richa Arora, Upasana Issar, Rita Kakkar
Hydroxamic acids have emerged as the most promising candidates from among the different classes of inhibitors of urease. In order to understand the mechanism of their action, we have studied in detail using quantum mechanics the active site of Helicobacter pylori urease complexed with acetohydroxamic acid. A diverse library of ligands having the hydroxamate moiety has been prepared and docked into the active site of urease using the QM/MM methodology. It is found that hydroxamic acids with hydrophobic groups attached to them are more potent inhibitors of urease because they can easily penetrate the hydrophobic environment surrounding the active site...
May 1, 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29775342/boundaries-control-collective-dynamics-of-inertial-self-propelled-robots
#2
A Deblais, T Barois, T Guerin, P H Delville, R Vaudaine, J S Lintuvuori, J F Boudet, J C Baret, H Kellay
Simple ingredients, such as well-defined interactions and couplings for the velocity and orientation of self-propelled objects, are sufficient to produce complex collective behavior in assemblies of such entities. Here, we use assemblies of rodlike robots made motile through self-vibration. When confined in circular arenas, dilute assemblies of these rods act as a gas. Increasing the surface fraction leads to a collective behavior near the boundaries: polar clusters emerge while, in the bulk, gaslike behavior is retained...
May 4, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29773316/rapid-recovery-of-a-coral-dominated-eastern-tropical-pacific-reef-after-experimentally-produced-anthropogenic-disturbance
#3
Ranjan Muthukrishnan, Peggy Fong
Local anthropogenic stressors such as overfishing, nutrient enrichment and increased sediment loading have been shown to push coral reefs toward greater dominance by algae. In a few cases this shift has been temporary, with the ability to recover to a healthy coral-dominated community after disturbance, suggesting some systems have considerable resilience. However, an understanding of the circumstances under which reefs may recover is only beginning to emerge. We monitored recovery of a coral-dominated reef in the Eastern Tropical Pacific (ETP) after cessation of a ∼6 month multiple stressor experiment (with herbivore exclosure, nutrient addition, and sediment addition)...
May 7, 2018: Marine Environmental Research
https://www.readbyqxmd.com/read/29771923/invasion-complexity-at-large-spatial-scales-is-an-emergent-property-of-interactions-among-landscape-characteristics-and-invader-traits
#4
Ranjan Muthukrishnan, Adam S Davis, Nicholas R Jordan, James D Forester
Invasion potential should be part of the evaluation of candidate species for any species introduction. However, estimating invasion risks remains a challenging problem, particularly in complex landscapes. Certain plant traits are generally considered to increase invasive potential and there is an understanding that landscapes influence invasions dynamics, but little research has been done to explore how those drivers of invasions interact. We evaluate the relative roles of, and potential interactions between, plant invasiveness traits and landscape characteristics on invasions with a case study using a model parameterized for the potentially invasive biomass crop, Miscanthus × giganteus...
2018: PloS One
https://www.readbyqxmd.com/read/29771815/the-many-faces-of-patient-centered-simulation-implications-for-researchers
#5
Jennifer L Arnold, Frederic Rick D McKenzie, Jane Lindsay Miller, Mary E Mancini
INTRODUCTION: Patient-centered simulation for nonhealthcare providers is an emerging and innovative application for healthcare simulation. Currently, no consensus exists on what patient-centered simulation encompasses and outcomes research in this area is limited. Conceptually, patient-centered simulation aligns with the principles of patient- and family-centered care bringing this educational tool directly to patients and caregivers with the potential to improve patient care and outcomes...
May 15, 2018: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
https://www.readbyqxmd.com/read/29771811/use-of-emergency-manuals-during-actual-critical-events-in-china-a-multi-institutional-study
#6
Jeffrey Huang, Jiayan Wu, Christina Dai, Xianwei Zhang, Hui Ju, Yiqi Chen, Chunyuan Zhang, Fan Ye, Yi Tan, Yongbo Zong, Telong Liu
INTRODUCTION: Emergency manuals (EMs) can help healthcare providers respond to crises more efficiently. Three anesthesia EMs have been translated into Chinese. These EMs have been made publicly available as a free document downloadable in China. A year after these Chinese versions of EMs were published, we conducted a multi-institutional survey in China to assess the progress of how well EM had been adapted and used in the setting of critical events. METHODS: Our study used a multi-institutional, anonymous electronic survey...
May 16, 2018: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
https://www.readbyqxmd.com/read/29769666/an-unexpected-and-persistent-increase-in-global-emissions-of-ozone-depleting-cfc-11
#7
Stephen A Montzka, Geoff S Dutton, Pengfei Yu, Eric Ray, Robert W Portmann, John S Daniel, Lambert Kuijpers, Brad D Hall, Debra Mondeel, Carolina Siso, J David Nance, Matt Rigby, Alistair J Manning, Lei Hu, Fred Moore, Ben R Miller, James W Elkins
The Montreal Protocol was designed to protect the stratospheric ozone layer by enabling reductions in the abundance of ozone-depleting substances such as chlorofluorocarbons (CFCs) in the atmosphere1-3 . The reduction in the atmospheric concentration of trichlorofluoromethane (CFC-11) has made the second-largest contribution to the decline in the total atmospheric concentration of ozone-depleting chlorine since the 1990s 1 . However, CFC-11 still contributes one-quarter of all chlorine reaching the stratosphere, and a timely recovery of the stratospheric ozone layer depends on a sustained decline in CFC-11 concentrations 1 ...
May 2018: Nature
https://www.readbyqxmd.com/read/29768698/financial-viability-of-emergency-department-observation-unit-billing-models
#8
Christopher W Baugh, Pawan Suri, Christopher G Caspers, Michael A Granovsky, Keith Neal, Michael A Ross
BACKGROUND: Outpatients receive observation services to determine the need for inpatient admission. These services are usually provided without the use of condition-specific protocols and in an unstructured manner, scattered throughout a hospital in areas typically designated for inpatient care. Emergency department observation units (EDOUs) use protocolized care to offer an efficient alternative with shorter lengths of stay, lower costs and higher patient satisfaction. EDOU growth is limited by existing policy barriers that prevent a "two-service" model of separate professional billing for both emergency and observation services...
May 16, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29768693/coastal-ecosystems-on-a-tipping-point-global-warming-and-parasitism-combine-to-alter-community-structure-and-function
#9
Kim N Mouritsen, Mikkel M Sørensen, Robert Poulin, Brian L Fredensborg
Mounting evidence suggests that the transmission of certain parasites is facilitated by increasing temperatures, causing their host population to decline. However, no study has yet addressed how temperature and parasitism may combine to shape the functional structure of a whole host community in the face of global warming. Here, we apply an outdoor mesocosm approach supported by field surveys to elucidate this question in a diverse intertidal community of amphipods infected by the pathogenic microphallid trematode, Maritrema novaezealandensis...
May 16, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29768477/faster-clinical-response-to-the-onset-of-adverse-events-a-wearable-metacognitive-attention-aid-for-nurse-triage-of-clinical-alarms
#10
Daniel C McFarlane, Alexa K Doig, James A Agutter, Lara M Brewer, Noah D Syroid, Ranjeev Mittu
OBJECTIVE: This study evaluates the potential for improving patient safety by introducing a metacognitive attention aid that enables clinicians to more easily access and use existing alarm/alert information. It is hypothesized that this introduction will enable clinicians to easily triage alarm/alert events and quickly recognize emergent opportunities to adapt care delivery. The resulting faster response to clinically important alarms/alerts has the potential to prevent adverse events and reduce healthcare costs...
2018: PloS One
https://www.readbyqxmd.com/read/29768258/multiple-actions-of-rotenone-an-inhibitor-of-mitochondrial-respiratory-chain-on-ionic-currents-and-miniature-end-plate-potential-in-mouse-hippocampal-mhippoe-14-neurons
#11
Chin-Wei Huang, Kao-Min Lin, Te-Yu Hung, Yao-Chung Chuang, Sheng-Nan Wu
BACKGROUND/AIMS: Rotenone (Rot) is known to suppress the activity of complex I in the mitochondrial chain reaction; however, whether this compound has effects on ion currents in neurons remains largely unexplored. METHODS: With the aid of patch-clamp technology and simulation modeling, the effects of Rot on membrane ion currents present in mHippoE-14 cells were investigated. RESULTS: Addition of Rot produced an inhibitory action on the peak amplitude of INa with an IC50 value of 39...
May 11, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29768234/improved-experimental-time-of-ultra-large-bioassays-using-a-parallelised-microfluidic-biochip-architecture-scheduling
#12
Maryam Taajobian, Ali Jahanian
Digital microfluidic is an emerging technology to reduce the cost and time of experiments and improve the flexibility, automate-ability and correctness of biochemical assays. In many of applications such as drug discovery and DNA profiling, a large number of bio-operations (e.g. the chemical operations used in biology applications) must be done. In these applications, parallelising the operations will be critical in accuracy and cost of the process and digital microfluidic biochips can be considered as a reasonable platform...
June 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/29766336/ischaemic-preconditioning-protects-cardiomyocytes-from-anthracycline-induced-toxicity-via-the-pi3k-pathway
#13
Angshuman Maulik, Sean M Davidson, Izabela Piotrowska, Malcolm Walker, Derek M Yellon
PURPOSE: Anthracyclines cause chronic irreversible cardiac failure, but the mechanism remains poorly understood. Emerging data indicate that cardiac damage begins early, suggesting protective modalities delivered in the acute stage may confer prolonged benefit. Ischaemic preconditioning (IPC) activates the pro-survival reperfusion injury salvage kinase (RISK) pathway which involves PI3-kinase and MAPK/ERK1/2. METHODS: We investigated whether simulated IPC (sIPC), in the form of a sublethal exposure to a hypoxic buffer simulating ischaemic conditions followed by reoxygenation, protects primary adult rat cardiomyocytes against anthracycline-induced injury...
May 15, 2018: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/29765814/designing-of-phenol-based-%C3%AE-carbonic-anhydrase1-inhibitors-through-qsar-molecular-docking-and-md-simulation-approach
#14
Shahzaib Ahamad, Md Imtaiyaz Hassan, Neeraja Dwivedi
Tuberculosis (Tb) is an airborne infectious disease caused by Mycobacterium tuberculosis. Beta-carbonic anhydrase 1 ( β-CA1 ) has emerged as one of the potential targets for new antitubercular drug development. In this work, three-dimensional quantitative structure-activity relationships (3D-QSAR), molecular docking, and molecular dynamics (MD) simulation approaches were performed on a series of natural and synthetic phenol-based β-CA1 inhibitors. The developed 3D-QSAR model ( r 2  = 0.94, q 2  = 0...
May 2018: 3 Biotech
https://www.readbyqxmd.com/read/29765298/real-time-tracking-of-selective-auditory-attention-from-m-eeg-a-bayesian-filtering-approach
#15
Sina Miran, Sahar Akram, Alireza Sheikhattar, Jonathan Z Simon, Tao Zhang, Behtash Babadi
Humans are able to identify and track a target speaker amid a cacophony of acoustic interference, an ability which is often referred to as the cocktail party phenomenon. Results from several decades of studying this phenomenon have culminated in recent years in various promising attempts to decode the attentional state of a listener in a competing-speaker environment from non-invasive neuroimaging recordings such as magnetoencephalography (MEG) and electroencephalography (EEG). To this end, most existing approaches compute correlation-based measures by either regressing the features of each speech stream to the M/EEG channels (the decoding approach) or vice versa (the encoding approach)...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29764945/a-mechanism-of-unidirectional-transformation-leading-to-antibiotic-resistance-occurs-within-nasopharyngeal-pneumococcal-biofilm-consortia
#16
Santiago M Lattar, Xueqing Wu, Jennifer Brophy, Fuminori Sakai, Keith P Klugman, Jorge E Vidal
Streptococcus pneumoniae acquires genes for resistance to antibiotics such as streptomycin (Str) or trimethoprim (Tmp) by recombination via transformation of DNA released by other pneumococci and closely related species. Using naturally transformable pneumococci, including strain D39 serotype 2 (S2) and TIGR4 (S4), we studied whether pneumococcal nasopharyngeal transformation was symmetrical, asymmetrical, or unidirectional. Incubation of S2Tet and S4Str in a bioreactor simulating the human nasopharynx led to the generation of SpnTet/Str recombinants...
May 15, 2018: MBio
https://www.readbyqxmd.com/read/29764421/computational-analysis-of-the-receptor-binding-specificity-of-novel-influenza-a-h7n9-viruses
#17
Xinrui Zhou, Jie Zheng, Fransiskus Xaverius Ivan, Rui Yin, Shoba Ranganathan, Vincent T K Chow, Chee-Keong Kwoh
BACKGROUND: Influenza viruses are undergoing continuous and rapid evolution. The fatal influenza A/H7N9 has drawn attention since the first wave of infections in March 2013, and raised more grave concerns with its increased potential to spread among humans. Experimental studies have revealed several host and virulence markers, indicating differential host binding preferences which can help estimate the potential of causing a pandemic. Here we systematically investigate the sequence pattern and structural characteristics of novel influenza A/H7N9 using computational approaches...
May 9, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29763610/sequential-interactions-in-which-one-player-plays-first-and-another-responds-promote-cooperation-in-evolutionary-dynamical-simulations-of-single-shot-prisoner-s-dilemma-and-snowdrift-games
#18
Robert A Laird
Cooperation is a central topic in evolutionary biology because (a) it is difficult to reconcile why individuals would act in a way that benefits others if such action is costly to themselves, and (b) it underpins many of the 'major transitions of evolution', making it essential for explaining the origins of successively higher levels of biological organization. Within evolutionary game theory, the Prisoner's Dilemma and Snowdrift games are the main theoretical constructs used to study the evolution of cooperation in dyadic interactions...
May 12, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29762605/quantum-resonances-of-landau-damping-in-the-electromagnetic-response-of-metallic-nanoslabs
#19
S G Castillo-López, N M Makarov, F Pérez-Rodríguez
The resonant quantization of Landau damping in far-infrared absorption spectra of metal nano-thin films is predicted within the Kubo formalism. Specifically, it is found that the discretization of the electromagnetic and electron wave numbers inside a metal nanoslab produces quantum nonlocal resonances well-resolved at slab thicknesses smaller than the electromagnetic skin depth. Landau damping manifests itself precisely as such resonances, tracing the spectral curve obtained within the semiclassical Boltzmann approach...
May 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29762135/surface-morphology-of-molybdenum-silicide-films-upon-low-energy-ion-beam-sputtering
#20
Raul Gago, Miriam Jaafar, Francisco Javier Palomares Simon
The surface morphology of molybdenum silicide (Mo<sub>x</sub>Si<sub>1-x </sub>) films has been studied after low-energy Ar<sup>+</sup> ion-beam sputtering (IBS) to explore eventual pattern formation on compound targets and, simultaneously, gather information about the mechanisms behind silicide-assisted nanopatterning of silicon surfaces by IBS. For this purpose, Mo<sub>x</sub>Si<sub>1-x </sub> films with compositions below, equal and above the MoSi<sub>2</sub> stoichiometry (x = 0...
May 15, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
keyword
keyword
93054
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"