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Emergency simulation

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https://www.readbyqxmd.com/read/28943140/hospital-to-home-a-quality-improvement-initiative-to-implement-high-fidelity-simulation-training-for-caregivers-of-children-requiring-long-term-mechanical-ventilation
#1
Jodi Thrasher, Joyce Baker, Kathleen M Ventre, Sara E Martin, Jessica Dawson, Roberta Cox, Heather M Moore, Sarah Brethouwer, Sharon Sables-Baus, Christopher D Baker
BACKGROUND: Preparing families of children requiring long-term mechanical ventilation (LTMV) to manage medical emergencies at home is challenging. Opportunities for family caregivers to rehearse crisis management in a controlled setting before discharge are limited. OBJECTIVE: We aimed to create a multimodal discharge preparedness curriculum, incorporating high-fidelity simulation training, to prepare family caregivers of children with complex medical conditions requiring long-term mechanical ventilation...
September 21, 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28942716/analysis-of-compressive-properties-of-the-bioaid-hearing-aid-algorithm
#2
Nicholas R Clark, Wendy Lecluyse, Tim Jürgens
OBJECTIVE: This technical paper describes a biologically inspired hearing aid algorithm based on a computer model of the peripheral auditory system simulating basilar membrane compression, reflexive efferent feedback and its resulting properties. DESIGN: Two evaluations were conducted on the core part of the algorithm, which is an instantaneous compression sandwiched between the attenuation and envelope extraction processes of a relatively slow feedback compressor...
September 25, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28942647/pore-breathing-of-metal-organic-frameworks-by-environmental-transmission-electron-microscopy
#3
Lucas R Parent, Huy Pham, Joseph P Patterson, Michael S Denny, Seth M Cohen, Nathan C Gianneschi, Francesco Paesani
Metal-organic frameworks (MOFs) have emerged as an effective platform for the rational design of multifunctional materials, combining large specific surface areas with flexible, periodic frameworks that can undergo reversible structural transitions, or "breathing", upon temperature and pressure changes, and through gas adsorption/desorption processes. Although MOF breathing can be inferred from the analysis of adsorption isotherms, direct observation of the structural transitions has been lacking, and the underlying processes of framework-reorganization in individual MOF nanocrystals is largely unknown...
September 23, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28942268/computational-fluid-dynamics-and-additive-manufacturing-to-diagnose-and-treat-cardiovascular-disease
#4
REVIEW
Amanda Randles, David H Frakes, Jane A Leopold
Noninvasive engineering models are now being used for diagnosing and planning the treatment of cardiovascular disease. Techniques in computational modeling and additive manufacturing have matured concurrently, and results from simulations can inform and enable the design and optimization of therapeutic devices and treatment strategies. The emerging synergy between large-scale simulations and 3D printing is having a two-fold benefit: first, 3D printing can be used to validate the complex simulations, and second, the flow models can be used to improve treatment planning for cardiovascular disease...
September 20, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28939366/membrane-induced-organization-and-dynamics-of-the-n-terminal-domain-of-chemokine-receptor-cxcr1-insights-from-atomistic-simulations
#5
Shalmali Kharche, Manali Joshi, Durba Sengupta, Amitabha Chattopadhyay
The CXC chemokine receptor 1 (CXCR1) is an important member of the G protein-coupled receptor (GPCR) family in which the extracellular N-terminal domain has been implicated in ligand binding and selectivity. The structure of this domain has not yet been elucidated due to its inherent dynamics, but experimental evidence points toward membrane-dependent organization and dynamics. To gain molecular insight into the interaction of the N-terminal domain with the membrane bilayer, we performed a series of microsecond time scale atomistic simulations of the N-terminal domain of CXCR1 in the presence and absence of POPC bilayers...
September 19, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/28939300/high-throughput-migration-modelling-for-estimating-exposure-to-chemicals-in-food-packaging-in-screening-and-prioritization-tools
#6
Alexi S Ernstoff, Peter Fantke, Lei Huang, Olivier Jolliet
Specialty software and simplified models are often used to estimate migration of potentially toxic chemicals from packaging into food. Current models, however, are not suitable for emerging applications in decision-support tools, e.g. in Life Cycle Assessment and risk-based screening and prioritization, which require rapid computation of accurate estimates for diverse scenarios. To fulfil this need, we develop an accurate and rapid (high-throughput) model that estimates the fraction of organic chemicals migrating from polymeric packaging materials into foods...
September 19, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28935362/modeling-oil-spill-trajectory-in-bosphorus-for-contingency-planning
#7
Şafak Nur Ertürk Bozkurtoğlu
Bosphorus, is a strongly driven international maritime route between the Black Sea and the Sea of Marmara and is a high risk area for oil spill due to the heavy tanker traffic. In this study an oil spill trajectory model was developed for investigating the potential risks of accidental oil spills in Bosphorus. The proposed oil spill trajectory model combines the surface current velocity data obtained from a calibrated hydrodynamic model with the advection, spreading, and evaporation processes that are effective only on the sea surface and dominant for a couple of hours after the oil spill...
September 18, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28934485/detecting-gene-subnetworks-under-selection-in-biological-pathways
#8
Alexandre Gouy, Joséphine T Daub, Laurent Excoffier
Advances in high throughput sequencing technologies have created a gap between data production and functional data analysis. Indeed, phenotypes result from interactions between numerous genes, but traditional methods treat loci independently, missing important knowledge brought by network-level emerging properties. Therefore, detecting selection acting on multiple genes affecting the evolution of complex traits remains challenging. In this context, gene network analysis provides a powerful framework to study the evolution of adaptive traits and facilitates the interpretation of genome-wide data...
September 19, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28932923/dual-energy-bone-removal-computed-tomography-brct-preliminary-report-of-efficacy-of-acute-intracranial-hemorrhage-detection
#9
Norihito Naruto, Hidenori Tannai, Kazuma Nishikawa, Kentaro Yamagishi, Masahiko Hashimoto, Hideto Kawabe, Yuichi Kamisaki, Hisashi Sumiya, Satoshi Kuroda, Kyo Noguchi
PURPOSE: One of the major applications of dual-energy computed tomography (DECT) is automated bone removal (BR). We hypothesized that the visualization of acute intracranial hemorrhage could be improved on BRCT by removing bone as it has the highest density tissue in the head. This preliminary study evaluated the efficacy of a DE BR algorithm for the head CT of trauma patients. METHODS: Sixteen patients with acute intracranial hemorrhage within 1 day after head trauma were enrolled in this study...
September 20, 2017: Emergency Radiology
https://www.readbyqxmd.com/read/28931810/controlled-manipulation-of-oxygen-vacancies-using-nanoscale-flexoelectricity
#10
Saikat Das, Bo Wang, Ye Cao, Myung Rae Cho, Yeong Jae Shin, Sang Mo Yang, Lingfei Wang, Minu Kim, Sergei V Kalinin, Long-Qing Chen, Tae Won Noh
Oxygen vacancies, especially their distribution, are directly coupled to the electromagnetic properties of oxides and related emergent functionalities that have implications for device applications. Here using a homoepitaxial strontium titanate thin film, we demonstrate a controlled manipulation of the oxygen vacancy distribution using the mechanical force from a scanning probe microscope tip. By combining Kelvin probe force microscopy imaging and phase-field simulations, we show that oxygen vacancies can move under a stress-gradient-induced depolarisation field...
September 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28931635/a-computational-multiscale-agent-based-model-for-simulating-spatio-temporal-tumour-immune-response-to-pd1-and-pdl1-inhibition
#11
Chang Gong, Oleg Milberg, Bing Wang, Paolo Vicini, Rajesh Narwal, Lorin Roskos, Aleksander S Popel
When the immune system responds to tumour development, patterns of immune infiltrates emerge, highlighted by the expression of immune checkpoint-related molecules such as PDL1 on the surface of cancer cells. Such spatial heterogeneity carries information on intrinsic characteristics of the tumour lesion for individual patients, and thus is a potential source for biomarkers for anti-tumour therapeutics. We developed a systems biology multiscale agent-based model to capture the interactions between immune cells and cancer cells, and analysed the emergent global behaviour during tumour development and immunotherapy...
September 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28929750/hexagonal-boron-nitride-graphene-core-shell-arrays-formed-by-self-symmetrical-etching-growth
#12
Chenxiao Wang, Junlai Zuo, Lifang Tan, Mengqi Zeng, Qiqi Zhang, Huinan Xia, Wenhao Zhang, Yingshuang Fu, Lei Fu
The synthesis and integration of core-shell materials have been extensively explored in three-dimensional nanostructures, while they are hardly ever extended into the emerging two-dimensional (2D) research field. Herein, demonstrated by graphene (G) and hexagonal boron nitride (h-BN) and via a sequential chemical vapor deposition method, we succeed for the first time in synthesizing 2D h-BN-G core-shell arrays (CSA), which possess extremely high uniformity in shapes, sizes and distributions. Each of the core-shell unit is composed of G ring-shaped shell internally filled with h-BN circular core...
September 20, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28926706/structural-and-kinetic-characterization-of-the-intrinsically-disordered-protein-sev-ntail-through-enhanced-sampling-simulations
#13
Mattia Bernetti, Matteo Masetti, Fabio Pietrucci, Martin Blackledge, Malene Ringkjøbing Jensen, Maurizio Recanatini, Luca Mollica, Andrea Cavalli
Intrinsically disordered proteins (IDPs) are emerging as an important class of the proteome. Being able to interact with different molecular targets, they participate in many physiological and pathological activities. However, due to their intrinsically heterogeneous nature, determining the equilibrium properties of IDPs is still a challenge for biophysics. Herein, we applied state-of-the-art enhanced sampling methods to Sev NTAIL, a test case of IDPs, and constructed a bin-based kinetic model to unveil the underlying kinetics...
September 19, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28926010/economic-assessment-of-an-emerging-disease-the-case-of-schmallenberg-virus-in-france
#14
A Waret-Szkuta, P Alarcon, B Hasler, J Rushton, F Corbière, D Raboisson
Schmallenberg virus (SBV) was first detected in 2011 in Germany and then in France in 2012. This study simulates the production of different ruminant systems in France and estimates, through partial budget analyses, the economic cost of SBV at the farm level, under two disease scenarios (a high-impact and low-impact scenario). A partial budget is used to evaluate the financial effect of incremental changes, and includes only resources or production that will be changed. In the high-impact scenario, the estimated impact of SBV ranged from €23 to €43 per cow per year and €19 to €37 per ewe per year...
April 2017: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/28925991/a-multiscale-imaging-and-modelling-dataset-of-the-human-inner-ear
#15
Nicolas Gerber, Mauricio Reyes, Livia Barazzetti, Hans Martin Kjer, Sergio Vera, Martin Stauber, Pavel Mistrik, Mario Ceresa, Nerea Mangado, Wilhelm Wimmer, Thomas Stark, Rasmus R Paulsen, Stefan Weber, Marco Caversaccio, Miguel A González Ballester
Understanding the human inner ear anatomy and its internal structures is paramount to advance hearing implant technology. While the emergence of imaging devices allowed researchers to improve understanding of intracochlear structures, the difficulties to collect appropriate data has resulted in studies conducted with few samples. To assist the cochlear research community, a large collection of human temporal bone images is being made available. This data descriptor, therefore, describes a rich set of image volumes acquired using cone beam computed tomography and micro-CT modalities, accompanied by manual delineations of the cochlea and sub-compartments, a statistical shape model encoding its anatomical variability, and data for electrode insertion and electrical simulations...
September 19, 2017: Scientific Data
https://www.readbyqxmd.com/read/28925727/the-effect-of-person-order-on-egress-time-a-simulation-model-of-evacuation-from-a-neolithic-visitor-attraction
#16
Arthur Stewart, Eyad Elyan, John Isaacs, Leah McEwen, Lyn Wilson
OBJECTIVE: The aim of this study was to model the egress of visitors from a Neolithic visitor attraction. BACKGROUND: Tourism attracts increasing numbers of elderly and mobility-impaired visitors to our built-environment heritage sites. Some such sites have very limited and awkward access, were not designed for mass visitation, and may not be modifiable to facilitate disabled access. As a result, emergency evacuation planning must take cognizance of robust information, and in this study we aimed to establish the effect of visitor position on egress...
September 1, 2017: Human Factors
https://www.readbyqxmd.com/read/28925587/lessons-learned-from-the-development-and-parameterization-of-a-computer-simulation-model-to-evaluate-task-modification-for-healthcare-providers
#17
Parastu Kasaie, W David Kelton, Rachel M Ancona, Michael J Ward, Craig M Froehle, Michael S Lyons
Computer simulation is a highly advantageous method for understanding and improving healthcare operations with a wide variety of possible applications. Most computer-simulation studies in emergency medicine have sought to improve allocation of resources to meet demand, or to assess the impact of hospital and other system policies on emergency department (ED) throughput. These models have enabled essential discoveries that can be used to improve the general structure and functioning of EDs. Theoretically, computer simulation could also be used to examine the impact of adding or modifying specific provider tasks...
September 19, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28925571/human-factors-and-simulation-in-emergency-medicine
#18
Emily M Hayden, Ambrose H Wong, Jeremy Ackerman, Margaret K Sande, Charles Lei, Leo Kobayashi, Michael Cassara, Dylan D Cooper, Kimberly Perry, William E Lewandowski, Mark W Scerbo
This consensus group from the 2017 Academic Emergency Medicine Consensus Conference "Catalyzing System Change through Health Care Simulation: Systems, Competency, and Outcomes" held in Orlando, Florida on May 16, 2017 focused on the use of human factors and simulation in the field of emergency medicine. The human factors discipline is often underutilized within emergency medicine but has significant potential in improving the interface between technologies and individuals in the field. The discussion explored the domain of human factors, its benefits in medicine, how simulation can be a catalyst for human factors work in emergency medicine, and how emergency medicine can collaborate with human factors professionals to affect change...
September 19, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28924330/manufacturing-data-analytics-using-a-virtual-factory-representation
#19
Sanjay Jain, Guodong Shao, Seung-Jun Shin
Large manufacturers have been using simulation to support decision-making for design and production. However, with the advancement of technologies and the emergence of big data, simulation can be utilised to perform and support data analytics for associated performance gains. This requires not only significant model development expertise, but also huge data collection and analysis efforts. This paper presents an approach within the frameworks of Design Science Research Methodology and prototyping to address the challenge of increasing the use of modelling, simulation and data analytics in manufacturing via reduction of the development effort...
2017: International Journal of Production Economics
https://www.readbyqxmd.com/read/28924017/in-silico-analysis-of-the-regulation-of-the-photosynthetic-electron-transport-chain-in-c3-plants
#20
Alejandro Morales, Xinyou Yin, Jeremy Harbinson, Steven Michiel Driever, Jaap Molenaar, David M Kramer, Paul Struik
We present a new simulation model of the reactions in the photosynthetic electron transport chain of C3 species. We show that including recent insights about the regulation of the thylakoid proton motive force, ATP/NADPH balancing mechanisms (cyclic and non-cyclic alternative electron transport), and regulation of Rubisco activity, leads to emergent behaviors that may affect the operation and regulation of photosynthesis under different dynamic environmental conditions. The model was parameterized with experimental results in the literature, with a focus on Arabidopsis thaliana...
September 18, 2017: Plant Physiology
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