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https://www.readbyqxmd.com/read/28635647/virulence-genes-of-s-aureus-from-dairy-cow-mastitis-and-contagiousness-risk
#1
Giada Magro, Stefano Biffani, Giulietta Minozzi, Ralf Ehricht, Stefan Monecke, Mario Luini, Renata Piccinini
Staphylococcus aureus (S. aureus) is a major agent of dairy cow intramammary infections: the different prevalences of mastitis reported might be related to a combination of S. aureus virulence factors beyond host factors. The present study considered 169 isolates from different Italian dairy herds that were classified into four groups based on the prevalence of S. aureus infection at the first testing: low prevalence (LP), medium-low (MLP), medium-high (MHP) and high (HP). We aimed to correlate the presence of virulence genes with the prevalence of intramammary infections in order to develop new strategies for the control of S...
June 21, 2017: Toxins
https://www.readbyqxmd.com/read/28629202/a-novel-extreme-learning-machine-classification-model-for-e-nose-application-based-on-the-multiple-kernel-approach
#2
Yulin Jian, Daoyu Huang, Jia Yan, Kun Lu, Ying Huang, Tailai Wen, Tanyue Zeng, Shijie Zhong, Qilong Xie
A novel classification model, named the quantum-behaved particle swarm optimization (QPSO)-based weighted multiple kernel extreme learning machine (QWMK-ELM), is proposed in this paper. Experimental validation is carried out with two different electronic nose (e-nose) datasets. Being different from the existing multiple kernel extreme learning machine (MK-ELM) algorithms, the combination coefficients of base kernels are regarded as external parameters of single-hidden layer feedforward neural networks (SLFNs)...
June 19, 2017: Sensors
https://www.readbyqxmd.com/read/28617536/effects-of-mulberry-leaf-polysaccharide-on-oxidative-stress-in-pancreatic-%C3%AE-cells-of-type-2-diabetic-rats
#3
C-G Liu, Y-P Ma, X-J Zhang
OBJECTIVE: To explore and discuss the effects and mechanisms of mulberry leaf polysaccharide (MLP) on oxidative stress in pancreatic β-cells of type 2 diabetic rats. MATERIALS AND METHODS: The model of diabetic rats was established by inducing the Sprague-Dawley (SD) rats with high-sugar and high-fat diet for 6 weeks and then giving them streptozotocin (STZ) by single intraperitoneal injection. The mulberry leaf polysaccharide was administered via gavage daily for 8 weeks, and the tissue morphology was observed through electron microscopy...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28611579/stacked-autoencoders-for-the-p300-component-detection
#4
Lukáš Vařeka, Pavel Mautner
Novel neural network training methods (commonly referred to as deep learning) have emerged in recent years. Using a combination of unsupervised pre-training and subsequent fine-tuning, deep neural networks have become one of the most reliable classification methods. Since deep neural networks are especially powerful for high-dimensional and non-linear feature vectors, electroencephalography (EEG) and event-related potentials (ERPs) are one of the promising applications. Furthermore, to the authors' best knowledge, there are very few papers that study deep neural networks for EEG/ERP data...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28610432/qsar-model-for-prediction-of-the-therapeutic-potency-of-n-benzylpiperidine-derivatives-as-ache-inhibitors
#5
S Bitam, M Hamadache, S Hanini
A new family of AChE inhibitors, N-benzylpiperidines, showed exceptional efficacy in vitro and in vivo, minimal side effects and high selectivity for acetylcholinesterase (AChE). Three regression methods were chosen in this work to develop robust predictive models, namely multiple linear regression (MLR), genetic function approximation (GFA) and multilayer perceptron network (MLP). Ten descriptors were selected for a dataset of 99 molecules, using a genetic algorithm. The best results were obtained for MLP with a 10-6-1 artificial neural network model trained with the Broyden-Fletcher-Goldfarb-Shanno (BFGS) algorithm...
June 14, 2017: SAR and QSAR in Environmental Research
https://www.readbyqxmd.com/read/28535743/acceptability-of-complementary-foods-that-incorporate-moringa-oleifera-leaf-powder-among-infants-and-their-caregivers
#6
Laurene Boateng, Ruth Nyarko, Matilda Asante, Matilda Steiner-Asiedu
BACKGROUND: Moringa Oleifera leaf powder (MLP) is a nutrient-rich and readily available food resource that has the potential to improve the micronutrient quality of complementary foods in developing countries. OBJECTIVE: To investigate the acceptability of complementary foods fortified with MLP. METHODS: Moringa Oleifera leaf powder was fed to infants either as part of a cereal-legume complementary food blend (MCL-35 g) or by sprinkling as a food supplement (MS-5 g) on infant's usual foods...
January 1, 2017: Food and Nutrition Bulletin
https://www.readbyqxmd.com/read/28499398/biomechanical-evaluation-of-a-novel-dualplate-fixation-method-for-proximal-humeral-fractures-without-medial-support
#7
Yu He, Yaoshen Zhang, Yan Wang, Dongsheng Zhou, Fu Wang
BACKGROUND: Comminuted fractures of the proximal humerus are generally treated with the locking plate system, and clinical results are satisfactory. However, unstable support of the medial column results in varus malunion and screw perforation. We designed a novel medial anatomical locking plate (MLP) to directly support the medial column. Theoretically, the combined application of locking plate and MLP (LPMP) would directly provide strong dual-column stability. We hypothesized that the LPMP could provide greater construct stability than the locking plate alone (LP), locking plate combined with a fibular graft (LPSG), and locking plate combined with a distal radius plate (LPDP)...
May 12, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28490578/investigating-clinical-issues-by-genotyping-of-medically-important-fungi-why-and-how
#8
REVIEW
Alexandre Alanio, Marie Desnos-Ollivier, Dea Garcia-Hermoso, Stéphane Bretagne
Genotyping studies of medically important fungi have addressed elucidation of outbreaks, nosocomial transmissions, infection routes, and genotype-phenotype correlations, of which secondary resistance has been most intensively investigated. Two methods have emerged because of their high discriminatory power and reproducibility: multilocus sequence typing (MLST) and microsatellite length polymorphism (MLP) using short tandem repeat (STR) markers. MLST relies on single-nucleotide polymorphisms within the coding regions of housekeeping genes...
July 2017: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/28484935/computational-models-for-the-classification-of-mpges-1-inhibitors-with-fingerprint-descriptors
#9
Zhonghua Xia, Aixia Yan
Human microsomal prostaglandin [Formula: see text] synthase (mPGES)-1 is a promising drug target for inflammation and other diseases with inflammatory symptoms. In this work, we built classification models which were able to classify mPGES-1 inhibitors into two groups: highly active inhibitors and weakly active inhibitors. A dataset of 1910 mPGES-1 inhibitors was separated into a training set and a test set by two methods, by a Kohonen's self-organizing map or by random selection. The molecules were represented by different types of fingerprint descriptors including MACCS keys (MACCS), CDK fingerprints, Estate fingerprints, PubChem fingerprints, substructure fingerprints and 2D atom pairs fingerprint...
May 8, 2017: Molecular Diversity
https://www.readbyqxmd.com/read/28476191/analysis-of-normal-hematopoietic-stem-and-progenitor-cell-contents-in-childhood-acute-leukemia-bone-marrow
#10
Juan Carlos Balandrán, Eduardo Vadillo, David Dozal, Alfonso Reyes-López, Antonio Sandoval-Cabrera, Merle Denisse Laffont-Ortiz, Jessica L Prieto-Chávez, Armando Vilchis-Ordoñez, Henry Quintela-Nuñez Del Prado, Héctor Mayani, Juan Carlos Núñez-Enríquez, Juan Manuel Mejía-Aranguré, Briceida López-Martínez, Elva Jiménez-Hernández, Rosana Pelayo
BACKGROUND AND AIMS: Childhood acute leukemias (AL) are characterized by the excessive production of malignant precursor cells at the expense of effective blood cell development. The dominance of leukemic cells over normal progenitors may result in either direct suppression of functional hematopoiesis or remodeling of microenvironmental niches, contributing to BM failure and AL-associated mortality. We undertook this study to investigate the contents and functional activity of hematopoietic stem/progenitor cells (HSPC) and their relationship to immune cell production and risk status in AL pediatric patients...
November 2016: Archives of Medical Research
https://www.readbyqxmd.com/read/28462208/diagnosis-of-the-ocd-patients-using-drawing-features-of-the-bender-gestalt-shapes
#11
R Boostani, F Asadi, N Mohammadi
BACKGROUND: Since psychological tests such as questionnaire or drawing tests are almost qualitative, their results carry a degree of uncertainty and sometimes subjectivity. The deficiency of all drawing tests is that the assessment is carried out after drawing the objects and lots of information such as pen angle, speed, curvature and pressure are missed through the test. In other words, the psychologists cannot assess their patients while running the tests. One of the famous drawing tests to measure the degree of Obsession Compulsion Disorder (OCD) is the Bender Gestalt, though its reliability is not promising...
March 2017: Journal of Biomedical Physics & Engineering
https://www.readbyqxmd.com/read/28459832/a-shallow-convolutional-neural-network-for-blind-image-sharpness-assessment
#12
Shaode Yu, Shibin Wu, Lei Wang, Fan Jiang, Yaoqin Xie, Leida Li
Blind image quality assessment can be modeled as feature extraction followed by score prediction. It necessitates considerable expertise and efforts to handcraft features for optimal representation of perceptual image quality. This paper addresses blind image sharpness assessment by using a shallow convolutional neural network (CNN). The network takes single feature layer to unearth intrinsic features for image sharpness representation and utilizes multilayer perceptron (MLP) to rate image quality. Different from traditional methods, CNN integrates feature extraction and score prediction into an optimization procedure and retrieves features automatically from raw images...
2017: PloS One
https://www.readbyqxmd.com/read/28459697/early-detection-of-peak-demand-days-of-chronic-respiratory-diseases-emergency-department-visits-using-artificial-neural-networks
#13
Krishan Lal Khatri, Lakshman Tamil
Chronic Respiratory diseases, mainly asthma and Chronic Obstructive Pulmonary Disease (COPD), affect the lives of people by limiting their activities in various aspects. Overcrowding of hospital emergency departments (EDs) due to respiratory diseases in certain weather and environmental pollution conditions results in the degradation of quality of medical care, and even limits its availability. A useful tool for ED managers would be to forecast peak demand days so that they can take steps to improve the availability of medical care...
April 26, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28451951/gastrointestinal-mantle-cell-lymphoma-with-isolated-mass-and-multiple-lymphomatous-polyposis-report-of-two-cases
#14
Shunichi Yanai, Shotaro Nakamura, Satoko Yamaguchi, Keisuke Kawasaki, Kazuyuki Ishida, Tamotsu Sugai, Junji Umeno, Motohiro Esaki, Takayuki Matsumoto
We herein report two patients with mantle cell lymphoma (MCL), who had isolated mass and multiple lymphomatous polyposis (MLP) in the gastrointestinal tract. In case 1, esophagogastroduodenoscopy revealed a protruding mass in the duodenum and double-balloon endoscopy disclosed numerous polypoid lesions in the ileum. Case 2 had polyposis in the duodenum and a large mass-forming lesion in the ascending colon. Based on the histologic and immunohistochemical findings of the biopsy specimens, the diagnosis of MCL was made in both patients...
April 27, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28436410/a-new-approach-to-develop-computer-aided-diagnosis-scheme-of-breast-mass-classification-using-deep-learning-technology
#15
Yuchen Qiu, Shiju Yan, Rohith Reddy Gundreddy, Yunzhi Wang, Samuel Cheng, Hong Liu, Bin Zheng
PURPOSE: To develop and test a deep learning based computer-aided diagnosis (CAD) scheme of mammograms for classifying between malignant and benign masses. METHODS: An image dataset involving 560 regions of interest (ROIs) extracted from digital mammograms was used. After down-sampling each ROI from 512×512 to 64×64 pixel size, we applied an 8 layer deep learning network that involves 3 pairs of convolution-max-pooling layers for automatic feature extraction and a multiple layer perceptron (MLP) classifier for feature categorization to process ROIs...
April 18, 2017: Journal of X-ray Science and Technology
https://www.readbyqxmd.com/read/28434915/x-ray-crystallography-and-electron-microscopy-of-cross-and-multi-module-nonribosomal-peptide-synthetase-proteins-reveal-a-flexible-architecture
#16
Michael J Tarry, Asfarul S Haque, Khanh Huy Bui, T Martin Schmeing
Nonribosomal peptide synthetases (NRPS) are macromolecular machines that produce peptides with diverse activities. Structural information exists for domains, didomains, and even modules, but little is known about higher-order organization. We performed a multi-technique study on constructs from the dimodular NRPS DhbF. We determined a crystal structure of a cross-module construct including the adenylation (A) and peptidyl carrier protein (PCP) domains from module 1 and the condensation domain from module 2, complexed with an adenosine-vinylsulfonamide inhibitor and an MbtH-like protein (MLP)...
May 2, 2017: Structure
https://www.readbyqxmd.com/read/28429925/robot-assisted-laparoendoscopic-single-site-versus-mini-laparoscopic-pyeloplasty-a-comparison-of-perioperative-functional-and-cosmetic-results
#17
Cristian Fiori, Riccardo Bertolo, Matteo Manfredi, Fabrizio Mele, Daniele Amparore, Giovanni Cattaneo, Ivano Morra, Roberto M Scarpa, Francesco Porpiglia
BACKGROUND: New approaches have been developed to further reduce the invasiveness of laparoscopic pyeloplasty (P) as treatment for uretero-pelvic junction obstruction (UPJO). Aim of the study was to compare perioperative, functional and cosmetic results of mini-laparoscopic (mL-P) versus robot-assisted laparoendoscopic single-site P (rLESS-P). METHODS: Since April 2009 to June 2010, 12 adult patients with primary UPJO, BMI<25 and no previous abdominal surgeries were enrolled undergoing mLP (3-mm instruments only)...
April 20, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/28408281/comparison-of-ann-mlp-anfis-svm-and-rf-models-for-the-online-classification-of-heating-value-of-burning-municipal-solid-waste-in-circulating-fluidized-bed-incinerators
#18
Haihui You, Zengyi Ma, Yijun Tang, Yuelan Wang, Jianhua Yan, Mingjiang Ni, Kefa Cen, Qunxing Huang
The heating values, particularly lower heating values of burning municipal solid waste are critically important parameters in operating circulating fluidized bed incineration systems. However, the heating values change widely and frequently, while there is no reliable real-time instrument to measure heating values in the process of incinerating municipal solid waste. A rapid, cost-effective, and comparative methodology was proposed to evaluate the heating values of burning MSW online based on prior knowledge, expert experience, and data-mining techniques...
April 10, 2017: Waste Management
https://www.readbyqxmd.com/read/28406806/improved-hiv-and-tb-knowledge-and-competence-among-mid-level-providers-in-a-cluster-randomized-trial-of-one-on-one-mentorship-for-task-shifting
#19
Sarah Naikoba, Kaggwa Dan Senjovu, Pallen Mugabe, Carey McCarthy, Patricia L Riley, Damazo Trevor Kadengye, Shona Dalal
INTRODUCTION: Health worker shortages pose a challenge to the scale-up of HIV care and treatment in Uganda. Training mid-level providers (MLP) in the provision of HIV and TB treatment can expand existing health workforce capacity and access to HIV services. METHODS: We conducted a cluster-randomized trial of, on-site clinical mentorship for HIV and TB care at 10 health facilities in rural Uganda. Twenty MLP and were randomly assigned to an intervention of eight hours a week of one on one mentorship, every six weeks over a nine month period; and another twenty to the control of no clinical mentorship...
April 12, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28377757/mycobacterial-cultures-contain-cell-size-and-density-specific-sub-populations-of-cells-with-significant-differential-susceptibility-to-antibiotics-oxidative-and-nitrite-stress
#20
Srinivasan Vijay, Rashmi Ravindran Nair, Deepti Sharan, Kishor Jakkala, Nagaraja Mukkayyan, Sharmada Swaminath, Atul Pradhan, Niranjan V Joshi, Parthasarathi Ajitkumar
The present study shows the existence of two specific sub-populations of Mycobacterium smegmatis and Mycobacterium tuberculosis cells differing in size and density, in the mid-log phase (MLP) cultures, with significant differential susceptibility to antibiotic, oxidative, and nitrite stress. One of these sub-populations (~10% of the total population), contained short-sized cells (SCs) generated through highly-deviated asymmetric cell division (ACD) of normal/long-sized mother cells and symmetric cell divisions (SCD) of short-sized mother cells...
2017: Frontiers in Microbiology
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