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https://www.readbyqxmd.com/read/28429925/robot-assisted-laparoendoscopic-single-site-versus-mini-laparoscopic-pyeloplasty-a-comparison-of-perioperative-functional-and-cosmetic-results
#1
Cristian Fiori, Riccardo Bertolo, Matteo Manfredi, Fabrizio Mele, Daniele Amparore, Giovanni Cattaneo, Ivano Morra, Roberto M Scarpa, Francesco Porpiglia
BACKGROUND: New approaches have been developed to further reduce the invasiveness of laparoscopic pyeloplasty (P) as treatment for uretero-pelvic junction obstruction (UPJO). Aim of the study was to compare perioperative, functional and cosmetic results of mini-laparoscopic (mL-P) versus robot-assisted laparoendoscopic single-site P (rLESS-P). METHODS: Since April 2009 to June 2010, 12 adult patients with primary UPJO, BMI<25 and no previous abdominal surgeries were enrolled undergoing mLP (3-mm instruments only)...
April 20, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/28408281/comparison-of-ann-mlp-anfis-svm-and-rf-models-for-the-online-classification-of-heating-value-of-burning-municipal-solid-waste-in-circulating-fluidized-bed-incinerators
#2
Haihui You, Zengyi Ma, Yijun Tang, Yuelan Wang, Jianhua Yan, Mingjiang Ni, Kefa Cen, Qunxing Huang
The heating values, particularly lower heating values of burning municipal solid waste are critically important parameters in operating circulating fluidized bed incineration systems. However, the heating values change widely and frequently, while there is no reliable real-time instrument to measure heating values in the process of incinerating municipal solid waste. A rapid, cost-effective, and comparative methodology was proposed to evaluate the heating values of burning MSW online based on prior knowledge, expert experience, and data-mining techniques...
April 10, 2017: Waste Management
https://www.readbyqxmd.com/read/28406806/improved-hiv-and-tb-knowledge-and-competence-among-mid-level-providers-in-a-cluster-randomized-trial-of-one-on-one-mentorship-for-task-shifting
#3
Sarah Naikoba, Kaggwa Dan Senjovu, Pallen Mugabe, Carey McCarthy, Patricia L Riley, Damazo Trevor Kadengye, Shona Dalal
INTRODUCTION: Health worker shortages pose a challenge to the scale-up of HIV care and treatment in Uganda. Training mid-level providers (MLP) in the provision of HIV and TB treatment can expand existing health workforce capacity and access to HIV services. METHODS: We conducted a cluster-randomized trial of, on-site clinical mentorship for HIV and TB care at 10 health facilities in rural Uganda. Twenty MLP and were randomly assigned to an intervention of eight hours a week of one on one mentorship, every six weeks over a nine month period; and another twenty to the control of no clinical mentorship...
April 12, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28377757/mycobacterial-cultures-contain-cell-size-and-density-specific-sub-populations-of-cells-with-significant-differential-susceptibility-to-antibiotics-oxidative-and-nitrite-stress
#4
Srinivasan Vijay, Rashmi Ravindran Nair, Deepti Sharan, Kishor Jakkala, Nagaraja Mukkayyan, Sharmada Swaminath, Atul Pradhan, Niranjan V Joshi, Parthasarathi Ajitkumar
The present study shows the existence of two specific sub-populations of Mycobacterium smegmatis and Mycobacterium tuberculosis cells differing in size and density, in the mid-log phase (MLP) cultures, with significant differential susceptibility to antibiotic, oxidative, and nitrite stress. One of these sub-populations (~10% of the total population), contained short-sized cells (SCs) generated through highly-deviated asymmetric cell division (ACD) of normal/long-sized mother cells and symmetric cell divisions (SCD) of short-sized mother cells...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28377582/nociceptive-drg-neurons-express-muscle-lim-protein-upon-axonal-injury
#5
Evgeny Levin, Anastasia Andreadaki, Philipp Gobrecht, Frank Bosse, Dietmar Fischer
Muscle lim protein (MLP) has long been regarded as a cytosolic and nuclear muscular protein. Here, we show that MLP is also expressed in a subpopulation of adult rat dorsal root ganglia (DRG) neurons in response to axonal injury, while the protein was not detectable in naïve cells. Detailed immunohistochemical analysis of L4/L5 DRG revealed ~3% of MLP-positive neurons 2 days after complete sciatic nerve crush and maximum ~10% after 4-14 days. Similarly, in mixed cultures from cervical, thoracic, lumbar and sacral DRG ~6% of neurons were MLP-positive after 2 days and maximal 17% after 3 days...
April 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28371526/development-of-a-hypoxic-radiosensitizer-prodrug-liposome-delivery-dna-repair-inhibitor-dbait-combination-with-radiotherapy-for-glioma-therapy
#6
Hongmei Liu, Yifan Cai, Yafei Zhang, Yandong Xie, Hui Qiu, Lei Hua, Xuejiao Liu, Yuling Li, Jun Lu, Longzhen Zhang, Rutong Yu
Gliomas are highly radioresistant tumors, mainly due to hypoxia in the core region of the gliomas and efficient DNA double-strand break repair. However, the design of a radiosensitizer incorporating the two above mechanisms is difficult and has rarely been reported. Thus, this study develops a hypoxic radiosensitizer-prodrug liposome (MLP) to deliver the DNA repair inhibitor Dbait (MLP/Dbait) to achieve the simultaneous entry of radiosensitizers with two different mechanisms into the glioma. MLP/Dbait effectively sensitizes glioma cells to X-ray radiotherapy (RT)...
March 30, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28369518/misregulation-of-calcium-handling-proteins-promotes-hyperactivation-of-calcineurin-nfat-signaling-in-skeletal-muscle-of-dm1-mice
#7
Aymeric Ravel-Chapuis, Guy Bélanger, Jocelyn Côté, Robin N Michel, Bernard J Jasmin
Myotonic Dystrophy type 1 (DM1) is caused by an expansion of CUG repeats in DMPK mRNAs. This mutation affects alternative splicing through misregulation of RNA-binding proteins. Amongst pre-mRNAs that are misspliced, several code for proteins involved in calcium homeostasis suggesting that calcium-handling and signaling are perturbed in DM1. Here, we analyzed expression of such proteins in DM1 mouse muscle. We found that the levels of several sarcoplasmic reticulum proteins (SERCA1, sarcolipin and calsequestrin) are altered, likely contributing to an imbalance in calcium homeostasis...
March 27, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28353684/posture-detection-based-on-smart-cushion-for-wheelchair-users
#8
Congcong Ma, Wenfeng Li, Raffaele Gravina, Giancarlo Fortino
The postures of wheelchair users can reveal their sitting habit, mood, and even predict health risks such as pressure ulcers or lower back pain. Mining the hidden information of the postures can reveal their wellness and general health conditions. In this paper, a cushion-based posture recognition system is used to process pressure sensor signals for the detection of user's posture in the wheelchair. The proposed posture detection method is composed of three main steps: data level classification for posture detection, backward selection of sensor configuration, and recognition results compared with previous literature...
March 29, 2017: Sensors
https://www.readbyqxmd.com/read/28344192/effect-of-investigational-kisspeptin-metastin-analog-tak-683-on-luteinizing-hormone-secretion-at-different-stages-of-the-luteal-phase-in-goats
#9
Larasati Puji Rahayu, Mohammed El Behiry, Natsumi Endo, Tomomi Tanaka
This study aimed to examine the response of luteinizing hormone (LH) secretion and ovarian steroid profile to TAK-683, an investigational metastin/kisspeptin analog, through treatment during different stages of the luteal phase in goats. Nine cycling Shiba goats (4.4 ± 2.3 years old) were assigned to early luteal phase (ELP, n = 4), mid-luteal phase (MLP, n = 4), and control (n = 5) groups. The ELP and MLP groups were administered 50 µg of TAK-683 intravenously on either day 5 or between days 7-14 after ovulation, respectively...
March 25, 2017: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/28331490/ranking-of-sites-for-installation-of-hydropower-plant-using-mlp-neural-network-trained-with-ga-a-madm-approach
#10
Benjamin A Shimray, Kh Manglem Singh, Thongam Khelchandra, R K Mehta
Every energy system which we consider is an entity by itself, defined by parameters which are interrelated according to some physical laws. In recent year tremendous importance is given in research on site selection in an imprecise environment. In this context, decision making for the suitable location of power plant installation site is an issue of relevance. Environmental impact assessment is often used as a legislative requirement in site selection for decades. The purpose of this current work is to develop a model for decision makers to rank or classify various power plant projects according to multiple criteria attributes such as air quality, water quality, cost of energy delivery, ecological impact, natural hazard, and project duration...
2017: Computational Intelligence and Neuroscience
https://www.readbyqxmd.com/read/28328517/convolution-in-convolution-for-network-in-network
#11
Yanwei Pang, Manli Sun, Xiaoheng Jiang, Xuelong Li
Network in network (NiN) is an effective instance and an important extension of deep convolutional neural network consisting of alternating convolutional layers and pooling layers. Instead of using a linear filter for convolution, NiN utilizes shallow multilayer perceptron (MLP), a nonlinear function, to replace the linear filter. Because of the powerfulness of MLP and 1 x 1 convolutions in spatial domain, NiN has stronger ability of feature representation and hence results in better recognition performance...
March 16, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28318505/machine-learning-in-the-prediction-of-cardiac-epicardial-and-mediastinal-fat-volumes
#12
É O Rodrigues, V H A Pinheiro, P Liatsis, A Conci
We propose a methodology to predict the cardiac epicardial and mediastinal fat volumes in computed tomography images using regression algorithms. The obtained results indicate that it is feasible to predict these fats with a high degree of correlation, thus alleviating the requirement for manual or automatic segmentation of both fat volumes. Instead, segmenting just one of them suffices, while the volume of the other may be predicted fairly precisely. The correlation coefficient obtained by the Rotation Forest algorithm using MLP Regressor for predicting the mediastinal fat based on the epicardial fat was 0...
February 24, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28316837/combination-of-navigated-macular-laser-photocoagulation-and-anti-vegf-therapy-precise-treatment-for-macular-edema-under-dry-retinal-conditions
#13
Ernest V Boiko, Dmitrii S Maltsev
Purpose. To compare the controllability of navigated macular laser photocoagulation (MLP) in dry versus edematous retina and validate that pretreatment diagnostic images can be used as basis for navigated MLP after the macular edema (ME) has been resolved. Materials and Methods. Group 1 was divided into subgroup 1 (dry retina MLP) and subgroup 2 (MLP in ME) for comparisons of laser-burn diameters. In group 2, the areas and locations of ME before an intravitreal injection of anti-VEGF (IVAV) were compared with those of recurrent ME...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28283501/phase-ii-conjugates-of-urolithins-isolated-from-human-urine-and-potential-role-of-%C3%AE-glucuronidases-in-their-disposition
#14
Jakub P Piwowarski, Iwona Stanisławska, Sebastian Granica, Joanna Stefańska, Anna K Kiss
In recent years, many xenobiotics derived from natural products have been shown to undergo extensive metabolism by gut microbiota. Ellagitannins, which are high molecular polyphenols, are metabolized to dibenzo[b,d]pyran-6-one derivatives- urolithins. These compounds, in contrast with their parental compounds, have good bioavailability and are found in plasma and urine at micromolar concentrations. In vivo studies conducted for ellagitannin-containing natural products indicate their beneficial health effects towards inflammation and cancer, which are associated with the formation of urolithins...
March 10, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28282603/nicotine-can-modulate-the-effects-of-the-mesenchymal-stem-cells-on-neutrophils
#15
Samira Pourtayeb, Seyyed Meysam Abtahi Froushani
PURPOSE: It has been revealed that mesenchymal stem cells (MSCs) express some of the nicotinic receptor subunits. Moreover, the crosstalk between MSCs and neutrophils is not far-fetched. Therefore, the aim of the present study is to determine the role of nicotine on the effects of MSCs on neutrophils. METHODS: After the isolation of mesenchymal stem cells from the bone marrow of rats, these cells were pulsed with different concentrations of nicotine (0, 0.1, 0.5, and 1μM) for different periods (24, 48, and 72h)...
March 7, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28269817/features-extraction-and-multi-classification-of-semg-using-a-gpu-accelerated-ga-mlp-hybrid-algorithm
#16
Weizhen Luo, Zhongnan Zhang, Tingxi Wen, Chunfeng Li, Ziheng Luo
BACKGROUND: Surface electromyography (sEMG) signal is the combined effect of superficial muscle EMG and neural electrical activity. In recent years, researchers did large amount of human-machine system studies by using the physiological signals as control signals. OBJECTIVE: To develop and test a new multi-classification method to improve performance of analyzing sEMG signals based on public sEMG dataset. METHODS: First, ten features were selected as candidate features...
2017: Journal of X-ray Science and Technology
https://www.readbyqxmd.com/read/28269711/improving-odorant-chemical-class-prediction-with-multi-layer-perceptrons-using-temporal-odorant-spike-responses-from-drosophila-melanogaster-olfactory-receptor-neurons
#17
Luqman R Bachtiar, Richard D Newcomb, Andrew V Kralicek, Charles P Unsworth
In this work, we examine the possibility of improving the prediction performance of an olfactory biosensor through the use of temporal spiking data. We present an Artificial Neural Network (ANN), in the form of an optimal hybrid Multi-Layer Perceptron (MLP) system for the classification of chemical odorants from olfactory receptor neuron spike responses of the Drosophila melanogaster fruit fly (DmOrs). The data used in this study contains the responses to 34 odorants from 6 individual DmOrs, of which we exploit the temporal spiking responses of a 500ms odorant stimulus window...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28269669/pca-criterion-for-svm-mlp-classifier-for-flavivirus-biomarker-from-salivary-sers-spectra-at-febrile-stage
#18
A R M Radzol, Khuan Y Lee, W Mansor, I S Omar
Non-structural protein (NS1) has been conceded as one of the biomarkers for flavivirus that causes diseases with life threatening consequences. NS1 is an antigen that allows detection of the illness at febrile stage, mostly from blood samples currently. Our work here intends to define an optimum model for PCA-SVM with MLP kernel for classification of flavivirus biomarker, NS1 molecule, from SERS spectra of saliva, which to the best of our knowledge has never been explored. Since performance of the model depends on the PCA criterion and MLP parameters, both are examined in tandem...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28235391/sar-and-qsar-study-on-the-bioactivities-of-human-epidermal-growth-factor-receptor-2-her2-inhibitors
#19
D Qu, A Yan, J S Zhang
In this paper, structure-activity relationship (SAR, classification) and quantitative structure-activity relationship (QSAR) models have been established to predict the bioactivity of human epidermal growth factor receptor-2 (HER2) inhibitors. For the SAR study, we established six SAR (or classification) models to distinguish highly and weakly active HER2 inhibitors. The dataset contained 868 HER2 inhibitors, which was split into a training set including 580 inhibitors and a test set including 288 inhibitors by a Kohonen's self-organizing map (SOM), or a random method...
February 2017: SAR and QSAR in Environmental Research
https://www.readbyqxmd.com/read/28227973/improving-odorant-chemical-class-prediction-with-multi-layer-perceptrons-using-temporal-odorant-spike-responses-from-drosophila-melanogaster-olfactory-receptor-neurons
#20
Luqman R Bachtiar, Richard D Newcomb, Andrew V Kralicek, Charles P Unsworth, Luqman R Bachtiar, Richard D Newcomb, Andrew V Kralicek, Charles P Unsworth, Charles P Unsworth, Andrew V Kralicek, Richard D Newcomb, Luqman R Bachtiar
In this work, we examine the possibility of improving the prediction performance of an olfactory biosensor through the use of temporal spiking data. We present an Artificial Neural Network (ANN), in the form of an optimal hybrid Multi-Layer Perceptron (MLP) system for the classification of chemical odorants from olfactory receptor neuron spike responses of the Drosophila melanogaster fruit fly (DmOrs). The data used in this study contains the responses to 34 odorants from 6 individual DmOrs, of which we exploit the temporal spiking responses of a 500ms odorant stimulus window...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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