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https://www.readbyqxmd.com/read/28092904/cml-with-complex-chromosome-rearrangements-and-dysplastic-megakaryocytes
#1
Zhaodong Xu, Jean McGowan-Jordan
No abstract text is available yet for this article.
July 28, 2016: Blood
https://www.readbyqxmd.com/read/28092670/neuropilin-1-is-upregulated-in-the-adaptive-response-of-prostate-tumors-to-androgen-targeted-therapies-and-is-prognostic-of-metastatic-progression-and-patient-mortality
#2
B W C Tse, M Volpert, E Ratther, N Stylianou, M Nouri, K McGowan, M L Lehman, S J McPherson, M Roshan-Moniri, M S Butler, J Caradec, C Y Gregory-Evans, J McGovern, R Das, M Takhar, N Erho, M Alshalafa, E Davicioni, E M Schaeffer, R B Jenkins, A E Ross, R J Karnes, R B Den, L Fazli, P A Gregory, M E Gleave, E D Williams, P S Rennie, R Buttyan, J H Gunter, L A Selth, P J Russell, C C Nelson, B G Hollier
Recent evidence has implicated the transmembrane co-receptor neuropilin-1 (NRP1) in cancer progression. Primarily known as a regulator of neuronal guidance and angiogenesis, NRP1 is also expressed in multiple human malignancies, where it promotes tumor angiogenesis. However, non-angiogenic roles of NRP1 in tumor progression remain poorly characterized. In this study, we define NRP1 as an androgen-repressed gene whose expression is elevated during the adaptation of prostate tumors to androgen-targeted therapies (ATTs), and subsequent progression to metastatic castration-resistant prostate cancer (mCRPC)...
January 16, 2017: Oncogene
https://www.readbyqxmd.com/read/28075056/m1-aminopeptidases-as-drug-targets-broad-applications-or-therapeutic-niche
#3
REVIEW
Nyssa Drinkwater, Jisook Lee, Wei Yang, Tess R Malcolm, Sheena McGowan
M1 aminopeptidase enzymes are a diverse family of metalloenzymes characterized by conserved structure and reaction specificity. Excluding viruses, M1 aminopeptidases are distributed throughout all phyla, and have been implicated in a wide range of functions including cell maintenance, growth and development, and defense. The structure and catalytic mechanism of M1 aminopeptidases are well understood, and make them ideal candidates for the design of small molecule inhibitors. As a result, many research groups have assessed their utility as therapeutic targets for both infectious and chronic diseases of humans, and many inhibitors with a range of target specificities and potential therapeutic applications have been developed...
January 11, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28068434/annexin-s100a-protein-family-regulation-through-p14arf-p53-activation-a-role-in-cell-survival-and-predicting-treatment-outcomes-in-breast-cancer
#4
Diana Hatoum, Daniel Yagoub, Alireza Ahadi, Najah T Nassif, Eileen M McGowan
The annexin family and S100A associated proteins are important regulators of diverse calcium-dependent cellular processes including cell division, growth regulation and apoptosis. Dysfunction of individual annexin and S100A proteins is associated with cancer progression, metastasis and cancer drug resistance. This manuscript describes the novel finding of differential regulation of the annexin and S100A family of proteins by activation of p53 in breast cancer cells. Additionally, the observed differential regulation is found to be beneficial to the survival of breast cancer cells and to influence treatment efficacy...
2017: PloS One
https://www.readbyqxmd.com/read/28067911/de-novo-mutations-in-smchd1-cause-bosma-arhinia-microphthalmia-syndrome-and-abrogate-nasal-development
#5
Christopher T Gordon, Shifeng Xue, Gökhan Yigit, Hicham Filali, Kelan Chen, Nadine Rosin, Koh-Ichiro Yoshiura, Myriam Oufadem, Tamara J Beck, Ruth McGowan, Alex C Magee, Janine Altmüller, Camille Dion, Holger Thiele, Alexandra D Gurzau, Peter Nürnberg, Dieter Meschede, Wolfgang Mühlbauer, Nobuhiko Okamoto, Vinod Varghese, Rachel Irving, Sabine Sigaudy, Denise Williams, S Faisal Ahmed, Carine Bonnard, Mung Kei Kong, Ilham Ratbi, Nawfal Fejjal, Meriem Fikri, Siham Chafai Elalaoui, Hallvard Reigstad, Christine Bole-Feysot, Patrick Nitschké, Nicola Ragge, Nicolas Lévy, Gökhan Tunçbilek, Audrey S M Teo, Michael L Cunningham, Abdelaziz Sefiani, Hülya Kayserili, James M Murphy, Chalermpong Chatdokmaiprai, Axel M Hillmer, Duangrurdee Wattanasirichaigoon, Stanislas Lyonnet, Frédérique Magdinier, Asif Javed, Marnie E Blewitt, Jeanne Amiel, Bernd Wollnik, Bruno Reversade
Bosma arhinia microphthalmia syndrome (BAMS) is an extremely rare and striking condition characterized by complete absence of the nose with or without ocular defects. We report here that missense mutations in the epigenetic regulator SMCHD1 mapping to the extended ATPase domain of the encoded protein cause BAMS in all 14 cases studied. All mutations were de novo where parental DNA was available. Biochemical tests and in vivo assays in Xenopus laevis embryos suggest that these mutations may behave as gain-of-function alleles...
January 9, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28067689/eight-years-of-growth-and-change-in-uk-molecular-radiotherapy-with-implications-for-the-future-internal-dosimetry-users-group-survey-results-from-2007-to-2015
#6
Bruno Rojas, Claire Hooker, Daniel R McGowan, Matthew J Guy, Jill Tipping
No abstract text is available yet for this article.
January 6, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28064554/evaluating-bempedoic-acid-for-the-treatment-of-hyperlipidaemia
#7
Peter Penson, Mary McGowan, Maciej Banach
Despite the effectiveness of statins in the treatment of lipid disorders, residual risk still exists, and hitherto studies where additional drugs were added to statin therapy have been mainly negative or the outcomes were very modest. Therefore there is still a need for new and effective oral agents in the combination therapy of lipid disorders. Areas Covered: The review covers the current state of knowledge on the mechanism of action of bempedoic acid (ETC-1002) and results from recent clinical studies. Expert Opinion: ETC-1002 is a novel oral lipid-lowering therapy...
January 9, 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28064405/a-systematic-review-of-circadian-function-chronotype-and-chronotherapy-in-attention-deficit-hyperactivity-disorder
#8
REVIEW
Andrew N Coogan, Niall M McGowan
Reports of sleep disturbances in attention deficit hyperactivity disorder (ADHD) are common in both children and adults; however, the aetiology of such disturbances is poorly understood. One potentially important mechanism which may be implicated in disrupted sleep in ADHD is the circadian CLOCK, a known key regulator of the sleep/wake cycle. In this systematic review, we analyse the evidence for circadian rhythm changes associated with ADHD, as well as assessing evidence for therapeutic approaches involving the circadian CLOCK in ADHD...
January 7, 2017: Attention Deficit and Hyperactivity Disorders
https://www.readbyqxmd.com/read/28062913/understanding-the-developmental-pathways-pulmonary-fibroblasts-may-follow-during-alveolar-regeneration
#9
REVIEW
Stephen McGowan
Although pulmonary alveolar interstitial fibroblasts are less specialized than their epithelial and endothelial neighbors, they play essential roles during development and in response to lung injury. At birth, they must adapt to the sudden mechanical changes imposed by the onset of respiration and to a higher ambient oxygen concentration. In diseases such as bronchopulmonary dysplasia and interstitial fibrosis, their adaptive responses are overwhelmed leading to compromised gas-exchange function. Thus, although fibroblasts do not directly participate in gas-exchange, they are essential for creating and maintaining an optimal environment at the alveolar epithelial-endothelial interface...
January 6, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28060286/the-use-of-ex-vivo-whole-organ-imaging-and-quantitative-tissue-histology-to-determine-the-bio-distribution-of-fluorescently-labeled-molecules
#10
Jeremy W D McGowan, Gene L Bidwell
Fluorescent labeling is a well-established process for examining the fate of labeled molecules under a variety of experimental conditions both in vitro and in vivo. Fluorescent probes are particularly useful in determining the bio-distribution of administered large molecules, where the addition of a small-molecule fluorescent label is unlikely to affect the kinetics or bio-distribution of the compound. A variety of methods exist to examine bio-distribution that vary significantly in the amount of effort required and whether the resulting measurements are fully quantitative, but using multiple methods in conjunction can provide a rapid and effective system for analyzing bio-distributions...
December 24, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28052482/an-extra-care-community-s-perceived-priorities-for-whole-system-relationships-a-q-methodological-study
#11
Paul Grimshaw, Linda McGowan, Elaine McNichol
Health and social care settings worldwide need to sustainably improve the quality of relationships across communities or 'whole systems'. This research informs the development of a relational framework based on stakeholder perspectives. It is grounded in an action research project with practitioners, and draws on a previous literature review, to present the underpinning elements of quality relationships as statements, organised under the headings of integrity, respect, fairness, compassion and trust. Using Q methodology, 27 participants, comprising a range of stakeholders (staff, residents, family and service providers), rank-ordered 48 statements based on perceptions of the importance of differing aspects of relationships...
January 3, 2017: Health & Social Care in the Community
https://www.readbyqxmd.com/read/28042893/the-experiences-of-myocardial-infarction-patients-readmitted-within-six-months-of-primary-percutaneous-coronary-intervention
#12
H Iles-Smith, C Deaton, M Campbell, C Mercer, L McGowan
AIM AND OBJECTIVES: This study explored the experiences of patients readmitted due to potential ischaemic heart disease (p-IHD) symptoms within 6 months of Primary Percutaneous Coronary Intervention (PPCI). BACKGROUND: Following myocardial infarction (MI) and PPCI, some patients experience p-IHD symptoms that may lead to readmission. Symptoms may be related to cardiac ischaemia, reduced psychological health or a comorbid condition. DESIGN: A qualitative study involving semi-structured, in-depth interviews conducted once, mean 196 (50 to 384) days following readmission (at least 6 months following original STEMI and PPCI)...
January 2, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28031642/plausible-role-of-acute-hiv-infection-mediated-immune-activation-in-causing-renal-allograft-rejection-a-case-report
#13
Vivek Jayaschandran, Prejith P Rajendran, Mamata Khanal, Prathik Krishnan, Poornima Ramadas, Asha Alex, Lakshmi Nambiar, David A Hirschwerk, Joseph P McGowan, Nicole Ali, Amit Basu, Madhu Bhaskaran, Ernesto P Molmenti
Current research states that AIDS pathogenesis has its roots in a chronic activation of immune system secondary to human immunodeficiency virus (HIV)-induced proliferation of T cells, B cells, NK cells, and macrophages. Immune activation due to acute HIV infection can be highly detrimental to allograft survival in a renal transplant recipient. In this report, we describe a 32-year-old African-American male patient who underwent a second live donor renal transplant, following which he developed acute allograft rejection coincident with newly acquired HIV seropositivity...
December 2016: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/28024696/pik3ca-mutations-as-prognostic-factor-in-squamous-cell-lung-carcinoma
#14
Marc McGowan, Aleksandra Silye Hoven, Marius Lund-Iversen, Steinar Solberg, Åslaug Helland, Fred R Hirsch, Odd Terje Brustugun
OBJECTIVES: Mutation in the PIK3CA gene is reported frequent in squamous cell carcinomas of the lung, but its potential prognostic role is still obscure. We have studied the prognostic importance of PIK3CA mutations as well as the relation to other markers in a large number of early stage lung cancers of squamous carcinoma subtype. PATIENTS AND METHODS: Tumour tissue was obtained from 308 consecutively operated lung cancer patients with squamous cell carcinoma in the period 2003-2013...
January 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/27986684/mtn-017-a-rectal-phase-2-extended-safety-and-acceptability-study-of-tenofovir-reduced-glycerin-1-gel
#15
Ross D Cranston, Javier R Lama, Barbra A Richardson, Alex Carballo-Diéguez, Ratiya Pamela Kunjara Na Ayudhya, Karen Liu, Karen B Patterson, Cheng-Shiun Leu, Beth Galaska, Cindy E Jacobson, Urvi M Parikh, Mark A Marzinke, Craig W Hendrix, Sherri Johnson, Jeanna M Piper, Cynthia Grossman, Ken S Ho, Jonathan Lucas, Jim Pickett, Linda-Gail Bekker, Suwat Chariyalertsak, Anupong Chitwarakorn, Pedro Gonzales, Timothy H Holtz, Albert Y Liu, Kenneth H Mayer, Carmen Zorrilla, Jill L Schwartz, James Rooney, Ian McGowan
BACKGROUND: HIV disproportionately affects men who have sex with men (MSM) and transgender women (TGW). Safe and acceptable topical HIV prevention methods that target the rectum are needed. METHODS: MTN-017 was a Phase 2, three-period, randomized sequence, open-label, expanded safety and acceptability crossover study comparing rectally applied reduced-glycerin (RG) 1% tenofovir (TFV) and oral emtricitabine/TFV disoproxil fumarate (FTC/TDF). In each 8-week study period participants were randomized to RG-TFV rectal gel daily; or RG-TFV rectal gel before and after receptive anal intercourse (RAI) (or at least twice weekly in the event of no RAI); or daily oral FTC/TDF...
December 16, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27955788/mass-deworming-to-improve-developmental-health-and-wellbeing-of-children-in-low-income-and-middle-income-countries-a-systematic-review-and-network-meta-analysis
#16
Vivian A Welch, Elizabeth Ghogomu, Alomgir Hossain, Shally Awasthi, Zulfiqar A Bhutta, Chisa Cumberbatch, Robert Fletcher, Jessie McGowan, Shari Krishnaratne, Elizabeth Kristjansson, Salim Sohani, Shalini Suresh, Peter Tugwell, Howard White, George A Wells
BACKGROUND: Soil-transmitted helminthiasis and schistosomiasis, considered among the neglected tropical diseases by WHO, affect more than a third of the world's population, with varying intensity of infection. We aimed to evaluate the effects of mass deworming for soil-transmitted helminths (with or without deworming for schistosomiasis or co-interventions) on growth, educational achievement, cognition, school attendance, quality of life, and adverse effects in children in endemic helminth areas...
January 2017: Lancet Global Health
https://www.readbyqxmd.com/read/27936485/x-ray-crystal-structure-of-cytochrome-p450-monooxygenase-cyp101j2-from-sphingobium-yanoikuyae-strain-b2
#17
Birgit Unterweger, Nyssa Drinkwater, Priscilla Johanesen, Dena Lyras, Geoffrey J Dumsday, Sheena McGowan
The cytochrome P450 monooxygenases (P450s) catalyse a vast array of oxygenation reactions that can be useful in biocatalytic applications. CYP101J2 from Sphingobium yanoikuyae is a P450 that catalyses the hydroxylation of 1,8-cineole. Here we report the crystallisation and X-ray structure elucidation of recombinant CYP101J2 to 1.8 Å resolution. The CYP101J2 structure shows the canonical P450-fold and has an open conformation in the absence of substrate. Analysis of the structure revealed that CYP101J2, in the absence of substrate, forms a well-ordered substrate-binding channel that suggests a unique form of substrate guidance in comparison to other bacterial 1,8-cineole-hydroxylating P450 enzymes...
December 9, 2016: Proteins
https://www.readbyqxmd.com/read/27919409/physiotherapy-managers-perceptions-of-their-leadership-effectiveness-a-multi-frame-analysis
#18
Emer McGowan, Cathal Walsh, Emma Stokes
OBJECTIVES: The purpose of this study was to investigate the leadership frames of physiotherapy managers in Ireland. To be effective leaders in today's challenging healthcare environment physiotherapy managers must employ a comprehensive, adaptable and balanced leadership style. DESIGN: This was a purposive, cross-sectional study. PARTICIPANTS: Physiotherapy managers were surveyed using the Bolman and Deal Leadership Orientations Instrument...
July 18, 2016: Physiotherapy
https://www.readbyqxmd.com/read/27917994/clinician-s-commentary-on-mcgowan-et-al-1
#19
COMMENT
Martine Quesnel
No abstract text is available yet for this article.
2016: Physiotherapy Canada. Physiothérapie Canada
https://www.readbyqxmd.com/read/27909357/perceptions-of-leadership-comparing-canadian-and-irish-physiotherapists-views
#20
Emer McGowan, Gillian Martin, Emma Stokes
Purpose: To contribute to the growing body of research on leadership in physiotherapy by comparing leadership-related perceptions of physiotherapists in Ireland and in Canada. Methods: This article compares the results of a survey of Canadian physiotherapists with those of the same survey administered to Irish physiotherapists. The results of both studies have previously been reported and are used here to allow a cultural comparison of the perceptions of physiotherapists. The present study used two-portion Z-tests to compare the percentage of physiotherapists in Ireland who self-declared as a leader with the percentage of physiotherapists in Canada who did so...
2016: Physiotherapy Canada. Physiothérapie Canada
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