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JOURNAL ARTICLE
Ping Chun Wu, Eunike C McGowan, Yan Quan Lee, Sudip Ghosh, Jenny Hansson, Martin L Olsson
BACKGROUND: Blood typing is essential for safe transfusions and is performed serologically or genetically. Genotyping predominantly focuses on coding regions, but non-coding variants may affect gene regulation, as demonstrated in the ABO, FY and XG systems. To uncover regulatory loci, we expanded a recently developed bioinformatics pipeline for discovery of non-coding variants by including additional epigenetic datasets. METHODS: Multiple datasets including ChIP-seq with erythroid transcription factors (TFs), histone modifications (H3K27ac, H3K4me1), and chromatin accessibility (ATAC-seq) were analyzed...
April 21, 2024: Transfusion
#2
REVIEW
Rebecca A Maher, Katie Wadden, Daniel Fuller, Fabien Basset, Hannah Murphy, Erin McGowan
Female infertility disproportionately affects people with obesity. Exercise often improves fertility outcomes for this population, however, there is limited prescriptive evidence. Specifically, there is a lack of information on the ideal type, frequency, intensity, and setting of exercise to improve fertility outcomes. Using principles of exercise prescription, this review aimed to describe the scope of exercise interventions that have been explored and fertility outcomes measured for people with female infertility and obesity...
April 1, 2024: Reproduction
#3
JOURNAL ARTICLE
T Michael O'Shea, Elizabeth T Jensen, Joe X Yi, Barry Lester, Judy L Aschner, Annemarie Stroustrup, Xueying Zhang, Monica McGrath, Keia Sanderson, Robert M Joseph, Rachana Singh, Amanda L Thompson, Julie Hofheimer, Betty Vohr, Elisabeth McGowan, Hudson Santos, Rebecca C Fry
OBJECTIVE: To evaluate associations between change in weight z-score after neonatal intensive care unit (NICU) discharge and neurodevelopmental outcomes and obesity at 12-48 months of age among individuals born very preterm. STUDY DESIGN: This secondary analysis used data from infants born very preterm participating in the Environmental influences on Child Health Outcomes cohort (n=1400). Growth during infancy was calculated as change in weight z-score between NICU discharge and follow-up at a mean of 27 months of age...
April 17, 2024: Journal of Pediatrics
#4
JOURNAL ARTICLE
Qi Lin, Ke Zhang, Charline Giguet-Covex, Fabien Arnaud, Suzanne McGowan, Ludovic Gielly, Eric Capo, Shixin Huang, Gentile Francesco Ficetola, Ji Shen, John A Dearing, Michael E Meadows
Understanding the transient dynamics of interlinked social-ecological systems (SES) is imperative for assessing sustainability in the Anthropocene. However, how to identify critical transitions in real-world SES remains a formidable challenge. In this study, we present an evolutionary framework to characterize these dynamics over an extended historical timeline. Our approach leverages multidecadal rates of change in socioeconomic data, paleoenvironmental, and cutting-edge sedimentary ancient DNA records from China's Yangtze River Delta, one of the most densely populated and intensively modified landscapes on Earth...
April 23, 2024: Proceedings of the National Academy of Sciences of the United States of America
#5
JOURNAL ARTICLE
Laura J McGowan, Deepti A John, Ryan P W Kenny, Emma C Joyes, Emma A Adams, Hosein Shabaninejad, Catherine Richmond, Fiona R Beyer, David Landes, Richard G Watt, Falko F Sniehotta, Martha Paisi, Claire Bambra, Dawn Craig, Eileen Kaner, Sheena E Ramsay
BACKGROUND: People experiencing homelessness co-occurring with substance use or offending ('severe and multiple disadvantage' SMD) often have high levels of poor oral health and related health behaviours (particularly, substance use, smoking, poor diet). This systematic review aimed to assess the effectiveness and cost-effectiveness of interventions in adults experiencing SMD to improve oral health and related health behaviours. METHODS AND FINDINGS: From inception to February 2023, five bibliographic databases (MEDLINE, EMBASE, PsycINFO, CINAHL, and Scopus) and grey literature were searched...
2024: PloS One
#6
JOURNAL ARTICLE
Daniel B Maselli, Lauren L Donnangelo, Pichamol Jirapinyo, Christopher C Thompson, Christopher E McGowan
Transoral outlet reduction (TORe) is an incisionless, endoscopic procedure to address weight recurrence after Roux-en-Y gastric bypass. Given the chronic, progressive nature of obesity and the minimally invasive, anatomy preserving technique of TORe, the procedure is expected to be met with high patient acceptance and widening clinical adoption. Nevertheless, the approach to TORe has been heterogeneous. As endoscopic bariatric therapies are increasingly incorporated into the multidisciplinary management of obesity, it is crucial to have a standardized, evidence-based framework for their implementation...
April 18, 2024: American Journal of Gastroenterology
#7
JOURNAL ARTICLE
Jane F Turton, Claire Perry, Kim McGowan, Jack A Turton, Russell Hope
Introduction. The first hybrid resistance/virulence plasmid, combining elements from virulence plasmids described in hypervirulent types of Klebsiella pneumoniae with those from conjugative resistance plasmids, was described in an isolate of sequence type (ST) 147 from 2016. Subsequently, this type has been increasingly associated with these plasmids. Hypothesis or gap statement. The extent of carriage of hybrid virulence/resistance plasmids in nosocomial isolates of K. pneumoniae requires further investigation...
April 2024: Journal of Medical Microbiology
#8
JOURNAL ARTICLE
Madeline Pearson, Ruth McGowan, Philip Greene, Wayne Lam, Zofia Miedzybrodzka, Jonathan Berg
Constitutional loss of SMAD4 function results in Juvenile Polyposis-Hereditary Haemorrhagic Telangiectasia Overlap Syndrome (JP-HHT). A retrospective multi-centre case-note review identified 28 patients with a pathogenic SMAD4 variant from 13 families across all Scottish Clinical Genetics Centres. This provided a complete clinical picture of the Scottish JP-HHT cohort. Colonic polyps were identified in 87% (23/28) and gastric polyps in 67% (12/18) of screened patients. Complication rates were high: 43% (10/23) of patients with polyps required a colectomy and 42% (5/12) required a gastrectomy...
April 16, 2024: European Journal of Human Genetics: EJHG
#9
JOURNAL ARTICLE
Lucy D'Agostino McGowan, Sarah C Lotspeich, Staci A Hepler
Missing data is a common challenge when analyzing epidemiological data, and imputation is often used to address this issue. Here, we investigate the scenario where a covariate used in an analysis has missingness and will be imputed. There are recommendations to include the outcome from the analysis model in the imputation model for missing covariates, but it is not necessarily clear if this recommendation always holds and why this is sometimes true. We examine deterministic imputation (i.e. single imputation with fixed values) and stochastic imputation (i...
April 16, 2024: Statistical Methods in Medical Research
#10
JOURNAL ARTICLE
Francesca A Ridley, Stephen P Rushton, Emily J Hickinbotham, Andrew J Suggitt, Philip J K McGowan, Louise Mair
Threat mapping is a necessary tool for identifying and abating direct threats to species in the ongoing extinction crisis. There are known gaps in the threat mapping literature for particular threats and geographic locations, and it remains unclear if the distribution of research effort is appropriately targeted relative to conservation need. We aimed to determine the drivers of threat mapping research effort and to quantify gaps that, if filled, could inform actions with the highest potential to reduce species' extinction risk...
April 16, 2024: Conservation Biology
#11
REVIEW
Bulent Okan Yildiz, Cesar Luiz Boguszewski, Margaret Cristina da Silva Boguszewski, Luca Busetto, Ozlem Celik, Ghada El-Hajj Fuleihan, Dimitrios G Goulis, Gary D Hammer, Megan R Haymart, Gregory Kaltsas, Jennifer R Law, Amanda Yuan Ling Lim, Anton Luger, Djuro Macut, Barbara McGowan, Michael McClung, Alexander Dimitri Miras, Mary Elizabeth Patti, Robin P Peeters, Duarte Pignatelli, Hamayle Saeed, Jennifer Sipos, Constantine A Stratakis, Marina Tsoli, A J van der Lely, Selma F Witchel, Dilek Yazici
EndoBridge 2023 took place on October 20-22, 2023, in Antalya, Turkey. Accredited by the European Council, the 3-day scientific program of the 11th Annual Meeting of EndoBridge included state-of-the-art lectures and interactive small group discussion sessions incorporating interesting and challenging clinical cases led by globally recognized leaders in the field and was well attended by a highly diverse audience. Following its established format over the years, the program provided a comprehensive update across all aspects of endocrinology and metabolism, including topics in pituitary, thyroid, bone, and adrenal disorders, neuroendocrine tumors, diabetes mellitus, obesity, nutrition, and lipid disorders...
April 15, 2024: Hormones: International Journal of Endocrinology and Metabolism
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JOURNAL ARTICLE
H B Carslake, G L Pinchbeck, C M Argo, A H A Dugdale, C M McGowan
Glucagon-like peptide-1 (GLP-1), the principal incretin in horses, may play a role in the pathophysiology of insulin dysregulation (ID). This study aimed to describe its concentration in response to three preserved forages and four dynamic tests for ID in ponies. Twelve adult ponies of mixed ID status were given a meal of hay, soaked hay or haylage, an in-feed oral glucose test (OGT), oral sugar test (OST), an oral test using a proprietary breakfast cereal (WEET) or a combined glucose-insulin tolerance test (CGIT) weekly in a randomised cross-over study...
April 9, 2024: Veterinary Journal
#13
JOURNAL ARTICLE
Elysse C Filipe, Sipiththa Velayuthar, Ashleigh Philp, Max Nobis, Sharissa L Latham, Amelia L Parker, Kendelle J Murphy, Kaitlin Wyllie, Gretel S Major, Osvaldo Contreras, Ellie T Y Mok, Ronaldo F Enriquez, Suzanne McGowan, Kristen Feher, Lake-Ee Quek, Sarah E Hancock, Michelle Yam, Emmi Tran, Yordanos F I Setargew, Joanna N Skhinas, Jessica L Chitty, Monica Phimmachanh, Jeremy Z R Han, Antonia L Cadell, Michael Papanicolaou, Hadi Mahmodi, Beata Kiedik, Simon Junankar, Samuel E Ross, Natasha Lam, Rhiannon Coulson, Jessica Yang, Anaiis Zaratzian, Andrew M Da Silva, Michael Tayao, Ian L Chin, Aurélie Cazet, Maya Kansara, Davendra Segara, Andrew Parker, Andrew J Hoy, Richard P Harvey, Ozren Bogdanovic, Paul Timpson, David R Croucher, Elgene Lim, Alexander Swarbrick, Jeff Holst, Nigel Turner, Yu Suk Choi, Irina V Kabakova, Andrew Philp, Thomas R Cox
In recent decades, the role of tumor biomechanics on cancer cell behavior at the primary site has been increasingly appreciated. However, the effect of primary tumor biomechanics on the latter stages of the metastatic cascade, such as metastatic seeding of secondary sites and outgrowth remains underappreciated. This work sought to address this in the context of triple negative breast cancer (TNBC), a cancer type known to aggressively disseminate at all stages of disease progression. Using mechanically tuneable model systems, mimicking the range of stiffness's typically found within breast tumors, it is found that, contrary to expectations, cancer cells exposed to softer microenvironments are more able to colonize secondary tissues...
April 11, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
#14
JOURNAL ARTICLE
Stephanie Joseph, Christopher E McGowan, Pichamol Jirapinyo, Allison R Schulman, Adarsh M Thaker, Barham K Abu Dayyeh, Daniel Maselli, Julia R Amundson, Christopher J Zimmermann, Vanessa N VanDruff, Simon Che, Shun Ishii, Michael B Ujiki
BACKGROUND: Endoscopic sleeve gastroplasty (ESG) is an innovative, minimally invasive bariatric procedure with an excellent safety and efficacy profile in adults with obesity. The purpose of the procedure is to shorten and tubularize the stomach along its greater curvature. Nevertheless, there is some heterogeneity in approach to ESG, which will be important to address as the procedure sees increasingly widespread clinical adoption. Here, we present an expert consensus on standardized ESG technique...
April 8, 2024: Journal of Gastrointestinal Surgery
#15
JOURNAL ARTICLE
Angela K McGowan, Stephen Greeley, Rya Griffis, Susan L Polan
No abstract text is available yet for this article.
May 2024: American Journal of Public Health
#16
JOURNAL ARTICLE
Ogochukwu Y Nwanne, Michelle L Rogers, Elisabeth C McGowan, Richard Tucker, Patrick M Vivier, Betty R Vohr
AIM: Study the association between neighbourhood risk and behaviour in extreme preterm (EPT) children. We hypothesised that EPT children living in high-risk neighbourhoods have increased risk of clinical range behaviour problems at age 30-36 months. METHODS: Retrospective analyses of Child Behavior Checklist (CBCL)scores for 739 EPTs born 2005-2016. Addresses were geocoded to identify census block groups and create high versus low-risk groups. Regression analyses assessed the impact of neighbourhood risk on behaviour...
April 10, 2024: Acta Paediatrica
#17
JOURNAL ARTICLE
Christina Johnson, Jinbo Chen, Mary P McGowan, Eric Tricou, Mary Card, Amy R Pettit, Tamar Klaiman, Daniel J Rader, Kevin G Volpp, Rinad S Beidas
BACKGROUND: Familial hypercholesterolemia (FH) is a heritable disorder affecting 1.3 million individuals in the USA. Eighty percent of people with FH are undiagnosed, particularly minoritized populations including Black or African American people, Asian or Asian American people, and women across racial groups. Family cascade screening is an evidence-based practice that can increase diagnosis and improve health outcomes but is rarely implemented in routine practice, representing an important care gap...
April 9, 2024: Implementation Science: IS
#18
JOURNAL ARTICLE
Natalie G McGowan, Judy H Zhong, Leonardo Trasande, Jason Hellmann, Sean P Heffron
BACKGROUND: Low-dose aspirin is ineffective for primary prevention of cardiovascular events in people with body weight greater than 70kg. While the prevalent explanation for this is reduced platelet cyclooxygenase-1 (COX-1) inhibition at higher body weights, supporting data are limited, thereby demanding further investigation of the reason(s) underlying this observation. We propose that aspirin-mediated cyclooxygenase-2 (COX-2) acetylation and the resulting synthesis of 15-epi-lipoxin A4 , a specialized pro-resolving mediator, is suboptimal in higher weight individuals, which may contribute to the clinical trial findings...
2024: International Journal of Clinical Trials
#19
JOURNAL ARTICLE
Yasmine Katzmann, Shalini Mulaparthi, Noreen McGowan
No abstract text is available yet for this article.
April 5, 2024: Journal of the National Comprehensive Cancer Network: JNCCN
#20
REVIEW
Salvatore Oliva, Emily Clarke McGowan
Eosinophilic gastrointestinal disorders (EGIDs) are becoming more common causing significant suffering and reduced quality of life. These conditions can affect different parts of the digestive system, either individually or in combination. Recognition of their link to allergic disorders or other gastrointestinal (GI) diseases has raised questions about their shared underlying mechanisms, which has had implications for diagnosis and management. The authors critically examine the current understanding of the connection between EGIDs and allergic conditions (ie, atopic dermatitis, allergic rhinitis, asthma, and food allergy) and GI diseases (ie, inflammatory bowel disease, celiac disease, gastroesophageal reflux disease, and motility disorders)...
May 2024: Immunology and Allergy Clinics of North America
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