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https://www.readbyqxmd.com/read/29303359/bayesian-penalised-likelihood-reconstruction-q-clear-of-18f-fluciclovine-pet-for-imaging-of-recurrent-prostate-cancer-semi-quantitative-and-clinical-evaluation
#1
Eugene J Teoh, Daniel R McGowan, David M Schuster, Maria Tsakok, Fergus V Gleeson, Kevin M Bradley
OBJECTIVE: 18F-Fluciclovine (FACBC) is an amino acid PET radiotracer approved for recurrent prostate cancer imaging. We investigate the use of Bayesian penalised likelihood (BPL) reconstruction for 18F-fluciclovine PET. METHODS: Fifteen 18F-fluciclovine scans were reconstructed using OSEM, OSEM+point spread function modeling (PSF) and BPL using β values 100-600. Lesion SUVmax, organ SUVmean and standard deviation were measured. De-identified reconstructions (OSEM, PSF, BPL using β200-600) from 10 cases were visually analysed by two readers who indicated their most and least preferred reconstructions, and scored overall image quality (IQ), noise level, background marrow IQ and lesion conspicuity...
January 5, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29285778/in-women-with-pcos-waist-circumference-is-a-better-surrogate-of-glucose-and-lipid-metabolism-than-disease-status-per-se
#2
A Pazderska, T Kyaw Tun, N Phelan, A McGowan, M Sherlock, L A Behan, G Boran, J Gibney
OBJECTIVE: Cardiometabolic abnormalities are recognised in polycystic ovary syndrome (PCOS). However, over-emphasis on PCOS as a risk factor potentially results in over-investigation and treatment of some women with, and under-recognition of cardiometabolic risk in obese women without PCOS. Our objective was to explore the association between waist circumference (WC) and indices of glucose and lipid metabolism in women with and without PCOS. DESIGN, PATIENTS AND MEASUREMENTS: (1) an exploratory cross-sectional study investigating association of potential cardiometabolic risk markers (PCOS status, anthropometric measures, hsCRP, HOMA-IR, SHBG, testosterone) with indices of glucose (frequently-sampled-intravenous-glucose-tolerance-test) and lipid metabolism (post-prandial studies and lipoprotein particle size) in 61 women with (n=29) and without (n=32) PCOS; (2) a cross-sectional study in 103 PCOS women and 102 BMI-matched controls to explore if between-group differences in indices of lipid and glucose metabolism persist after adjusting for WC...
December 29, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29281903/assessment-of-fgfr1-overexpression-and-over-activity-in-lung-cancer-cells-a-toolkit-for-anti-fgfr1-drug-screening
#3
Penghui Hu, Hongjie Chen, Eileen McGowan, Nina Ren, Ming Xu, Yiguang Lin
Lung cancer, mainly caused by smoking, is one of the most prevalent diseases in China resulting in high mortality rates. The increasing incidence of chronic disease due to lung cancer places a huge burden on the welfare and cost to the Chinese society. Amplification of the fibroblast growth factor receptor 1 (FGFR1) is associated with high incidence and mortality in lung cancer patients. FGFR1 signaling is implicated in oncogenic traits such as proliferation, cell survival, angiogenesis and migration. Targeting the FGFR1 and its ligand basic FGF (bFGF) is a key step forward in developing new therapies for this crippling disease...
December 27, 2017: Human Gene Therapy Methods
https://www.readbyqxmd.com/read/29274180/association-of-intralipid-intake-in-extremely-low-birth-weight-infants-with-neurodevelopmental-outcomes
#4
William Oh, Lynn Przystac, Leslie McKinley, Richard Tucker, Elisabeth C McGowan, Betty R Vohr
AIM: To determine if high intake of Intralipid, (IL) in extremely low birthweight (ELBW) neonates is associated with higher rates of neuroimpairment and Bayley III scores at 2 years corrected age. METHODS: Quartiles of IL received by 389 ELBW infants were linked to neurodevelopmental outcomes. Logistic regression analyses, adjusted for confounders, were done to determine the association between IL dose and neuroimpairment. Linear regression analyses were done to predict Bayley III scores...
December 23, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29259756/vu6010608-a-novel-mglu7-nam-from-a-series-of-n-2-1h-1-2-4-triazol-1-yl-5-trifluoromethoxy-phenyl-benzamides
#5
Carson W Reed, Kevin M McGowan, Paul K Spearing, Branden J Stansley, Hanna F Roenfanz, Darren W Engers, Alice L Rodriguez, Eileen M Engelberg, Vincent B Luscombe, Matthew T Loch, Daniel H Remke, Jerri M Rook, Anna L Blobaum, P Jeffrey Conn, Colleen M Niswender, Craig W Lindsley
Herein, we report the structure-activity relationships within a series of mGlu7 NAMs based on an N-(2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)benzamide core with excellent CNS penetration (Kp 1.9-5.8 and Kp,uu 0.4-1.4). Analogues in this series displayed steep SAR. Of these, VU6010608 (11a) emerged with robust efficacy in blocking high frequency stimulated long-term potentiation in electrophysiology studies.
December 14, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29249421/the-interplay-between-atrial-fibrillation-and-heart-failure-on-long-term-mortality-and-length-of-stay-insights-from-the-united-kingdom-acalm-registry
#6
Oliver J Ziff, Paul R Carter, John McGowan, Hardeep Uppal, Suresh Chandran, Stuart Russell, Kevin R Bainey, Rahul Potluri
BACKGROUND: There is concern that the development of heart failure and atrial fibrillation has a detrimental influence on clinical outcomes. The aim of this study was to assess all-cause mortality and length of hospital stay in patients with chronic and new-onset concomitant AF and HF. METHODS: Using the ACALM registry, we analysed adults hospitalised between 2000 and 2013 with AF and HF and assessed prevalence, mortality and length of hospital stay. Patients with HF and/or AF at baseline (study-entry) were compared with patients who developed new-onset disease during follow-up...
February 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29247701/adaptation-or-pathology-the-role-of-prenatal-stressor-type-and-intensity-in-the-developmental-programing-of-adult-phenotype
#7
REVIEW
Sophie St-Cyr, Patrick O McGowan
The mother is the major interface between the offspring and its prenatal environment. Prenatal toxins and stress-inducing physical agents are important factors programming the developmental trajectory of mammals that likely involve epigenetic modifications. However, prenatal stressors commonly-used in the laboratory (e.g. prenatal restraint stress and prenatal chronic variable stress) are typically administered at high intensities. These exposures typically lead to pathological phenotypes supporting the development origin of health and disease hypothesis...
December 13, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/29247207/a-rapid-review-examining-purchasing-changes-resulting-from-fiscal-measures-targeted-at-high-sugar-foods-and-sugar-sweetened-drinks
#8
Katharine E Roberts, Louisa J Ells, Victoria J McGowan, Theodora Machaira, Victoria C Targett, Rachel E Allen, Alison E Tedstone
To aim of the review was to examine the most recent (2010 onwards) research evidence on the health and behavioural impacts, in adults and children, of fiscal strategies that target high sugar foods and sugar-sweetened drinks (SSDs). A pragmatic rapid review was undertaken using a systematic search strategy. The review was part of a programme of work to support policy development in relation to high sugar food and SSDs. A total of 11 primary research publications were included, describing evidence from France (n = 1), the Netherlands (n = 3), and the United States of America (n = 7), assessed through a variety of study designs, with the majority in adult populations (n = 10)...
December 15, 2017: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29242560/characterising-the-nicotine-metabolite-ratio-and-its-association-with-treatment-choice-a-cross-sectional-analysis-of-stop-smoking-services-in-england
#9
Lion Shahab, Emily Mortimer, Linda Bauld, Jennifer A McGowan, Ann McNeill, Rachel F Tyndale
Pharmacotherapy provision based on Nicotine Metabolite Ratio (NMR) status (slow/normal metabolism) may improve smoking cessation rates. However, it is unclear whether NMR status is consistent across patient characteristics and current treatment choice. Data come from 1,826 participants attending Stop Smoking Services (SSS) across England in 2012/13. Sociodemographic, mental/physical health, smoking and treatment characteristics (nicotine replacement therapy vs. other pharmacotherapy; group vs. one-to-one behavioural support) were assessed...
December 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29240080/reinterpretation-of-sequence-variants-one-diagnostic-laboratory-s-experience-and-the-need-for-standard-guidelines
#10
Caitlin Chisholm, Hussein Daoud, Mahdi Ghani, Gabrielle Mettler, Jean McGowan-Jordan, Liz Sinclair-Bourque, Amanda Smith, Olga Jarinova
PurposeThe advent of next-generation sequencing resulted in substantial increases in the number of variants detected, interpreted, and reported by molecular genetics diagnostic laboratories. Recent publications have provided standards for the interpretation of sequence variants, but there are currently no standards regarding reinterpretation of these variants. Recognizing that significant changes in variant classification may occur over time, many genetics diagnostic laboratories have independently developed practices for variant reinterpretation...
December 14, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29232712/bioinformatic-analysis-reveals-new-determinants-of-antigenic-14-3-3-proteins-and-a-novel-antifungal-strategy
#11
Jenna E McGowan, Jacqueline Kratch, Saurabh Chattopadhyay, Bina Joe, Heather R Conti, Ritu Chakravarti
The ubiquitously expressed 14-3-3 family of proteins is evolutionarily conserved from yeast to mammals. Their involvement in humoral and cellular immune responses is emerging through studies in drosophila and humans. In humans, a select group of 14-3-3 isoforms are antigenic; however the determinants of their antigenicity are not known. Here, we show that although mammalian 14-3-3 proteins are mostly conserved, subtle differences between their isoforms may give rise to their antigenicity. We observed syntenic relations among all the isoforms of 14-3-3 for mammals, but not with that of birds or amphibians...
2017: PloS One
https://www.readbyqxmd.com/read/29232528/upmc-s-population-health-management-strategy-a-road-map-to-high-value-health-care
#12
Marion McGowan, Donna J Keyser, Suzanne Kinsky, Ellen Beckjord, Rosanne DeGrazia, William Shrank
No abstract text is available yet for this article.
December 12, 2017: Population Health Management
https://www.readbyqxmd.com/read/29226806/underestimation-of-specific-ige-measurements-using-extract-based-assays-on-undiluted-sera-revealed-through-dilution
#13
Alexander J Schuyler, Anubha Tripathi, Lisa J Workman, Jeffrey M Wilson, Elizabeth A Erwin, Monica G Lawrence, Emily C McGowan, Robert G Hamilton, Thomas A E Platts-Mills
No abstract text is available yet for this article.
December 6, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29226457/investigation-of-in-vitro-measurable-sperm-attributes-and-their-influence-on-electroejaculated-bull-semen-with-a-fixed-time-artificial-insemination-protocol-in-australian-bos-indicus-cattle
#14
N Satake, Saa Edwards, D Tutt, M R McGowan, G B Boe-Hansen
Increasing use of fixed-time artificial insemination (FTAI) in beef cattle production has presented an opportunity for the use of fresh or chilled semen as an alternative to standard cryopreserved semen. The objective of this study was to examine in vitro sperm function and pregnancy rate of electroejaculated semen, chilled and stored for 48 hr, compared to conventionally cryopreserved semen with an optimized FTAI protocol in Brahman cattle. Semen from three Brahman bulls was collected, and aliquots were extended in either chilled (at 5°C) or frozen (LN2 ) in a Tris-egg yolk extender base with 2...
December 11, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29220674/actb-loss-of-function-mutations-result-in-a-pleiotropic-developmental-disorder
#15
Sara Cuvertino, Helen M Stuart, Kate E Chandler, Neil A Roberts, Ruth Armstrong, Laura Bernardini, Sanjeev Bhaskar, Bert Callewaert, Jill Clayton-Smith, Cristina Hernando Davalillo, Charu Deshpande, Koenraad Devriendt, Maria C Digilio, Abhijit Dixit, Matthew Edwards, Jan M Friedman, Antonio Gonzalez-Meneses, Shelagh Joss, Bronwyn Kerr, Anne Katrin Lampe, Sylvie Langlois, Rachel Lennon, Philippe Loget, David Y T Ma, Ruth McGowan, Maryse Des Medt, James O'Sullivan, Sylvie Odent, Michael J Parker, Céline Pebrel-Richard, Florence Petit, Zornitza Stark, Sylvia Stockler-Ipsiroglu, Sigrid Tinschert, Pradeep Vasudevan, Olaya Villa, Susan M White, Farah R Zahir, Adrian S Woolf, Siddharth Banka
ACTB encodes β-actin, an abundant cytoskeletal housekeeping protein. In humans, postulated gain-of-function missense mutations cause Baraitser-Winter syndrome (BRWS), characterized by intellectual disability, cortical malformations, coloboma, sensorineural deafness, and typical facial features. To date, the consequences of loss-of-function ACTB mutations have not been proven conclusively. We describe heterozygous ACTB deletions and nonsense and frameshift mutations in 33 individuals with developmental delay, apparent intellectual disability, increased frequency of internal organ malformations (including those of the heart and the renal tract), growth retardation, and a recognizable facial gestalt (interrupted wavy eyebrows, dense eyelashes, wide nose, wide mouth, and a prominent chin) that is distinct from characteristics of individuals with BRWS...
December 7, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29214630/a-del-phenotype-attributed-to-rhd-exon-9-sequence-deletion-slipped-strand-mispairing-and-blood-group-polymorphisms
#16
Genghis H Lopez, Robyn M Turner, Eunike C McGowan, Elizna M Schoeman, Stacy A Scott, Helen O'Brien, Glenda M Millard, Eileen V Roulis, Amanda J Allen, Yew-Wah Liew, Robert L Flower, Catherine A Hyland
BACKGROUND: The RhD blood group antigen is extremely polymorphic and the DEL phenotype represents one such class of polymorphisms. The DEL phenotype prevalent in East Asian populations arises from a synonymous substitution defined as RHD*1227A. However, initially, based on genomic and cDNA studies, the genetic basis for a DEL phenotype in Taiwan was attributed to a deletion of RHD Exon 9 that was never verified at the genomic level by any other independent group. Here we investigate the genetic basis for a Caucasian donor with a DEL partial D phenotype and compare the genomic findings to those initial molecular studies...
December 6, 2017: Transfusion
https://www.readbyqxmd.com/read/29214401/predictors-of-surgical-outcomes-for-severe-cubital-tunnel-syndrome-a-review-of-146-patients
#17
Jinsong Tong, Zhen Dong, Bin Xu, Chenggang Zhang, Yudong Gu
BACKGROUND: Full recovery is unlikely for severe cubital tunnel syndrome, and prognostic factors remain uncertain. We aimed to identify predictors of surgical outcome for these patients. METHODS: One hundred forty-six patients with McGowan grade III cubital tunnel syndrome were evaluated retrospectively with a minimum follow-up of 2 years. All patients underwent either in situ decompression or subcutaneous transposition. The primary outcome measure was postoperative McGowan grade...
December 7, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29208233/from-testing-to-diagnostic-strategies-and-dia-prognostic-research
#18
EDITORIAL
J André Knottnerus, Peter Tugwell, Andrea C Tricco, Jessie McGowan
No abstract text is available yet for this article.
December 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29204528/serum-testosterone-changes-in-patients-treated-with-radiation-therapy-alone-for-prostate-cancer-on-nrg-oncology-rtog-9408
#19
R Charles Nichols, Chen Hu, Jean-Paul Bahary, Kenneth L Zeitzer, Luis Souhami, Mark H Leibenhaut, Marvin Rotman, Elizabeth M Gore, Alexander G Balogh, David McGowan, Jeff Michalski, Adam Raben, Shari Rudoler, Christopher U Jones, Howard Sandler
Objectives: We reviewed testosterone changes for patients who were treated with radiation therapy (RT) alone on NRG oncology RTOG 9408. Methods and materials: Patients (T1b-T2b, prostate-specific antigen <20 ng/mL) were randomized between RT alone and RT plus 4 months of androgen ablation. Serum testosterone (ST) levels were investigated at enrollment, RT completion, and the first follow-up 3 months after RT. The Wilcoxon signed rank test was used to compare pre- and post-treatment ST levels in patients who were randomized to the RT-alone arm...
October 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29202039/genomic-network-and-phylogenetic-analysis-of-the-oomycete-effector-arsenal
#20
Jamie McGowan, David A Fitzpatrick
The oomycetes are a class of microscopic, filamentous eukaryotes within the stramenopiles-alveolate-Rhizaria (SAR) supergroup and include ecologically significant animal and plant pathogens. Oomycetes secrete large arsenals of effector proteins that degrade host cell components, manipulate host immune responses, and induce necrosis, enabling parasitic colonization. This study investigated the expansion and evolution of effectors in 37 oomycete species in 4 oomycete orders, including Albuginales, Peronosporales, Pythiales, and Saprolegniales species...
November 2017: MSphere
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