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https://www.readbyqxmd.com/read/28199341/methods-for-calculating-protection-equality-for-conservation-planning
#1
Alienor L M Chauvenet, Caitlin D Kuempel, Jennifer McGowan, Maria Beger, Hugh P Possingham
Protected Areas (PAs) are a central part of biodiversity conservation strategies around the world. Today, PAs cover c15% of the Earth's land mass and c3% of the global oceans. These numbers are expected to grow rapidly to meet the Convention on Biological Diversity's Aichi Biodiversity target 11, which aims to see 17% and 10% of terrestrial and marine biomes protected, respectively, by 2020. This target also requires countries to ensure that PAs protect an "ecologically representative" sample of their biodiversity...
2017: PloS One
https://www.readbyqxmd.com/read/28197789/surgical-outcome-for-severe-cubital-tunnel-syndrome-in-patients-aged-70%C3%A2-years-a-mean-follow-up-of-4-5%C3%A2-years
#2
Jinsong Tong, Bin Xu, Zhen Dong, Chenggang Zhang, Yudong Gu
BACKGROUND: Surgical outcomes for cubital tunnel syndrome have been reported to be satisfactory, but could be compromised by advanced age and severe nerve compression. We aim to evaluate the prognosis of severe cubital tunnel syndrome in patients aged >70 years. METHODS: This retrospective study included 25 patients (26 extremities, all McGowan grade III, age >70 years); 21 underwent subcutaneous transposition and 5 in situ decompression. Postoperative follow-up lasted >2 years...
February 14, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28193617/prescribing-tamoxifen-in-primary-care-for-the-prevention-of-breast-cancer-a-national-online-survey-of-gps-attitudes
#3
Samuel G Smith, Robbie Foy, Jennifer A McGowan, Lindsay C Kobayashi, Andrea de Censi, Karen Brown, Lucy Side, Jack Cuzick
BACKGROUND: The cancer strategy for England (2015-2020) recommends GPs prescribe tamoxifen for breast cancer primary prevention among women at increased risk. AIM: To investigate GPs' attitudes towards prescribing tamoxifen. DESIGN AND SETTING: In an online survey, GPs in England, Northern Ireland, and Wales (n = 928) were randomised using a 2 × 2 between-subjects design to read one of four vignettes describing a healthy patient seeking a tamoxifen prescription...
February 13, 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/28185035/anthracycline-chemotherapy-and-cardiotoxicity
#4
John V McGowan, Robin Chung, Angshuman Maulik, Izabela Piotrowska, J Malcolm Walker, Derek M Yellon
Anthracycline chemotherapy maintains a prominent role in treating many forms of cancer. Cardiotoxic side effects limit their dosing and improved cancer outcomes expose the cancer survivor to increased cardiovascular morbidity and mortality. The basic mechanisms of cardiotoxicity may involve direct pathways for reactive oxygen species generation and topoisomerase 2 as well as other indirect pathways. Cardioprotective treatments are few and those that have been examined include renin angiotensin system blockade, beta blockers, or the iron chelator dexrazoxane...
February 9, 2017: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/28177261/stability-of-5p12-rantes-a-candidate-rectal-microbicide-in-human-rectal-lavage
#5
Fabrice Cerini, Robin E Offord, Ian McGowan, Oliver Hartley
In the absence of an effective vaccine, strategies to prevent HIV transmission are urgently needed. Condomless receptive anal intercourse represents a major route of transmission, and efforts are being made to develop strategies in which potent anti-HIV drugs are formulated for topical application to the rectum prior to sex. 5P12-RANTES is a promising candidate for such a purpose. It is an analogue of the human chemokine RANTES/CCL5, which potently blocks CCR5, the principal coreceptor used by HIV to enter and infect target cells...
February 8, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28175188/p587-fermentation-capacity-of-gut-microbiota-in-patients-with-inflammatory-bowel-disease-compared-to-healthy-controls
#6
M McGowan, M Kokkorou, M Rebull, Y Koh, D R Gaya, R Hansen, R K Russell, K Gerasimidis
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28153978/grizzly-bear-ursus-arctos-horribilis-locomotion-forelimb-joint-mechanics-across-speed-in-the-sagittal-and-frontal-planes
#7
Catherine L Shine, Charles T Robbins, O Lynne Nelson, Craig P McGowan
The majority of terrestrial locomotion studies have focused on parasagittal motion and paid less attention to forces or movement in the frontal plane. Our previous research has shown that grizzly bears produce higher medial ground reaction forces (lateral pushing from the animal) than would be expected for an upright mammal, suggesting frontal plane movement may be an important aspect of their locomotion. To examine this, we conducted an inverse dynamics analysis in sagittal and frontal planes, using ground reaction forces and position data from three high speed cameras of four adult female grizzly bears...
February 2, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28144760/routine-computer-tomography-imaging-for-the-detection-of-recurrences-in-high-risk-melanoma-patients
#8
Tristen S Park, Giao Q Phan, James C Yang, Udai Kammula, Marybeth S Hughes, Kasia Trebska-McGowan, Kathleen E Morton, Donald E White, Steven A Rosenberg, Richard M Sherry
BACKGROUND: The use of routine CT imaging for surveillance in asymptomatic patients with cutaneous melanoma is controversial. We report our experience using a surveillance strategy that included CT imaging for a cohort of patients with high-risk melanoma. METHODS: A total of 466 patients with high-risk cutaneous melanoma enrolled in adjuvant immunotherapy trials were followed for tumor progression by physical examination, labs, and CT imaging as defined by protocol...
January 31, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28138789/phrenic-nerve-palsy-secondary-to-parsonage-turner-syndrome-a-diagnosis-commonly-overlooked
#9
Tom McEnery, Ronan Walsh, Conor Burke, Aisling McGowan, John Faul, Liam Cormican
Neuralgic Amyotrophy (NA) or Parsonage-Turner syndrome is an idiopathic neuropathy commonly affecting the brachial plexus. Associated phrenic nerve involvement, though recognised, is thought to be very rare. We present a case series of four patients (all male, mean age 53) presenting with dyspnoea preceded by severe self-limiting upper limb and shoulder pain, with an elevated hemi-diaphragm on clinical examination and chest X-ray. Neurological examination of the upper limb at the time of presentation was normal...
January 30, 2017: Lung
https://www.readbyqxmd.com/read/28128336/prophylactic-ketamine-attenuates-learned-fear
#10
Josephine C McGowan, Christina T LaGamma, Sean C Lim, Melina Tsitsiklis, Yuval Neria, Rebecca A Brachman, Christine A Denny
Ketamine has been reported to be an efficacious antidepressant for major depressive disorder (MDD) and posttraumatic stress disorder (PTSD). Most recently, ketamine has also been shown to be prophylactic against stress-induced depressive-like behavior in mice. It remains unknown, however, when ketamine should be administered relative to a stressor in order to maximize its antidepressant and/or prophylactic effects. Moreover, it is unknown if ketamine can be prophylactic against subsequent stressors. We systematically administered ketamine at different time points relative to a fear experience in order to determine when ketamine is most effective at reducing fear expression or preventing fear reactivation...
January 27, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28127758/the-current-state-of-diagnostic-genetics-for-conditions-affecting-sex-development
#11
REVIEW
D Alhomaidah, R McGowan, S F Ahmed
Disorders of sex development (DSD), are a group of rare congenital conditions. Unlike 46, XX DSD where the cause is usually clear, identification of a cause of XY DSD is often unclear and may be attributed to a disorder of gonadal development, androgen synthesis or androgen action. Reaching a firm diagnosis is challenging and requires expertise within a framework that abides by the highest standards of clinical care. Whilst conditions associated with altered sex development have improved our fundamental understanding of sex and gonadal development, it is debatable whether this improvement in our understanding has improved the lives of people with DSD...
February 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28125983/fathers-views-and-experiences-of-their-own-mental-health-during-pregnancy-and-the-first-postnatal-year-a-qualitative-interview-study-of-men-participating-in-the-uk-born-and-bred-in-yorkshire-baby-cohort
#12
Z Darwin, P Galdas, S Hinchliff, E Littlewood, D McMillan, L McGowan, S Gilbody
BACKGROUND: The prevalence of fathers' depression and anxiety in the perinatal period (i.e. from conception to 1 year after birth) is approximately 5-10%, and 5-15%, respectively; their children face increased risk of adverse emotional and behavioural outcomes, independent of maternal mental health. Critically, fathers can be protective against the development of maternal perinatal mental health problems and their effects on child outcomes. Preventing and treating paternal mental health problems and promoting paternal psychological wellbeing may therefore benefit the family as a whole...
January 26, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28124389/evaluation-of-a-chemiluminescent-immunoassay-for-measurement-of-equine-insulin
#13
H B Carslake, G L Pinchbeck, C M McGowan
BACKGROUND: Many diagnostic tests for insulin dysregulation use reference intervals established with an insulin radioimmunoassay (RIA) that is no longer available. A chemiluminescent immunoassay (CLIA) is commonly used for the measurement of serum insulin concentration in clinical practice but requires further validation, especially at clinically relevant reference intervals. OBJECTIVES: To evaluate the CLIA for measurement of equine insulin and compare it to the previously validated, but now unavailable RIA...
January 26, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28118422/a-pilot-randomized-controlled-trial-of-a-guided-self-help-intervention-to-manage-chronic-orofacial-pain
#14
Joanna Goldthorpe, Karina Lovell, Sarah Peters, Linda McGowan, Imola Nemeth, Christopher Roberts, Vishal R Aggarwal
AIMS: To conduct a pilot trial to test the feasibility of a guided self-help intervention for chronic orofacial pain. METHODS: A pilot randomized controlled trial was conducted to compare the intervention with usual treatment. A total of 37 patients with chronic orofacial pain were randomized into either the intervention group (n = 19) or the usual treatment (control) group (n = 18). Validated outcome measures were used to measure the potential effectiveness of the intervention over a number of domains: physical and mental functioning (Short Form 36 [SF-36]); anxiety and depression (Hospital Anxiety and Depression Scale [HADS]); pain intensity and interference with life (Brief Pain Inventory [BPI]); disability (Manchester Orofacial Pain Disability Scale [MOPDS]); and illness behavior (Revised Illness Perceptions Questionnaire [IPQr])...
January 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28114205/two-suturing-techniques-for-the-prevention-and-treatment-of-nasal-valve-collapse-after-mohs-micrographic-surgery
#15
Anis Miladi, Joseph W McGowan, Heidi B Donnelly
BACKGROUND: Tumor extirpation of nonmelanoma skin cancer (NMSC) adjacent to the alar groove, using Mohs micrographic surgery (MMS), may risk causing internal nasal valve (INV) collapse, resulting in reduced airflow during inspiration. There are many surgical options described in the literature to repair INV collapse as a postoperative corrective procedure, but few exist as an intra-operative preventative procedure. OBJECTIVE: The authors present 2 distinct methods to prevent and treat INV collapse during the repair of a perialar surgical defect caused by MMS...
January 20, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28092904/cml-with-complex-chromosome-rearrangements-and-dysplastic-megakaryocytes
#16
Zhaodong Xu, Jean McGowan-Jordan
No abstract text is available yet for this article.
July 28, 2016: Blood
https://www.readbyqxmd.com/read/28092670/neuropilin-1-is-upregulated-in-the-adaptive-response-of-prostate-tumors-to-androgen-targeted-therapies-and-is-prognostic-of-metastatic-progression-and-patient-mortality
#17
B W C Tse, M Volpert, E Ratther, N Stylianou, M Nouri, K McGowan, M L Lehman, S J McPherson, M Roshan-Moniri, M S Butler, J Caradec, C Y Gregory-Evans, J McGovern, R Das, M Takhar, N Erho, M Alshalafa, E Davicioni, E M Schaeffer, R B Jenkins, A E Ross, R J Karnes, R B Den, L Fazli, P A Gregory, M E Gleave, E D Williams, P S Rennie, R Buttyan, J H Gunter, L A Selth, P J Russell, C C Nelson, B G Hollier
Recent evidence has implicated the transmembrane co-receptor neuropilin-1 (NRP1) in cancer progression. Primarily known as a regulator of neuronal guidance and angiogenesis, NRP1 is also expressed in multiple human malignancies, where it promotes tumor angiogenesis. However, non-angiogenic roles of NRP1 in tumor progression remain poorly characterized. In this study, we define NRP1 as an androgen-repressed gene whose expression is elevated during the adaptation of prostate tumors to androgen-targeted therapies (ATTs), and subsequent progression to metastatic castration-resistant prostate cancer (mCRPC)...
January 16, 2017: Oncogene
https://www.readbyqxmd.com/read/28075056/m1-aminopeptidases-as-drug-targets-broad-applications-or-therapeutic-niche
#18
REVIEW
Nyssa Drinkwater, Jisook Lee, Wei Yang, Tess R Malcolm, Sheena McGowan
M1 aminopeptidase enzymes are a diverse family of metalloenzymes characterized by conserved structure and reaction specificity. Excluding viruses, M1 aminopeptidases are distributed throughout all phyla, and have been implicated in a wide range of functions including cell maintenance, growth and development, and defense. The structure and catalytic mechanism of M1 aminopeptidases are well understood, and make them ideal candidates for the design of small-molecule inhibitors. As a result, many research groups have assessed their utility as therapeutic targets for both infectious and chronic diseases of humans, and many inhibitors with a range of target specificities and potential therapeutic applications have been developed...
January 11, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28068434/annexin-s100a-protein-family-regulation-through-p14arf-p53-activation-a-role-in-cell-survival-and-predicting-treatment-outcomes-in-breast-cancer
#19
Diana Hatoum, Daniel Yagoub, Alireza Ahadi, Najah T Nassif, Eileen M McGowan
The annexin family and S100A associated proteins are important regulators of diverse calcium-dependent cellular processes including cell division, growth regulation and apoptosis. Dysfunction of individual annexin and S100A proteins is associated with cancer progression, metastasis and cancer drug resistance. This manuscript describes the novel finding of differential regulation of the annexin and S100A family of proteins by activation of p53 in breast cancer cells. Additionally, the observed differential regulation is found to be beneficial to the survival of breast cancer cells and to influence treatment efficacy...
2017: PloS One
https://www.readbyqxmd.com/read/28067911/de-novo-mutations-in-smchd1-cause-bosma-arhinia-microphthalmia-syndrome-and-abrogate-nasal-development
#20
Christopher T Gordon, Shifeng Xue, Gökhan Yigit, Hicham Filali, Kelan Chen, Nadine Rosin, Koh-Ichiro Yoshiura, Myriam Oufadem, Tamara J Beck, Ruth McGowan, Alex C Magee, Janine Altmüller, Camille Dion, Holger Thiele, Alexandra D Gurzau, Peter Nürnberg, Dieter Meschede, Wolfgang Mühlbauer, Nobuhiko Okamoto, Vinod Varghese, Rachel Irving, Sabine Sigaudy, Denise Williams, S Faisal Ahmed, Carine Bonnard, Mung Kei Kong, Ilham Ratbi, Nawfal Fejjal, Meriem Fikri, Siham Chafai Elalaoui, Hallvard Reigstad, Christine Bole-Feysot, Patrick Nitschké, Nicola Ragge, Nicolas Lévy, Gökhan Tunçbilek, Audrey S M Teo, Michael L Cunningham, Abdelaziz Sefiani, Hülya Kayserili, James M Murphy, Chalermpong Chatdokmaiprai, Axel M Hillmer, Duangrurdee Wattanasirichaigoon, Stanislas Lyonnet, Frédérique Magdinier, Asif Javed, Marnie E Blewitt, Jeanne Amiel, Bernd Wollnik, Bruno Reversade
Bosma arhinia microphthalmia syndrome (BAMS) is an extremely rare and striking condition characterized by complete absence of the nose with or without ocular defects. We report here that missense mutations in the epigenetic regulator SMCHD1 mapping to the extended ATPase domain of the encoded protein cause BAMS in all 14 cases studied. All mutations were de novo where parental DNA was available. Biochemical tests and in vivo assays in Xenopus laevis embryos suggest that these mutations may behave as gain-of-function alleles...
January 9, 2017: Nature Genetics
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