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https://www.readbyqxmd.com/read/28731762/measurement-of-neutral-current-k-production-by-neutrinos-using-minerva
#1
C M Marshall, L Aliaga, O Altinok, L Bellantoni, A Bercellie, M Betancourt, A Bodek, A Bravar, T Cai, M F Carneiro, H da Motta, S A Dytman, G A Díaz, M Dunkman, B Eberly, E Endress, J Felix, L Fields, R Fine, A M Gago, R Galindo, H Gallagher, A Ghosh, T Golan, R Gran, D A Harris, A Higuera, K Hurtado, J Kleykamp, M Kordosky, T Le, E Maher, S Manly, W A Mann, D A Martinez Caicedo, K S McFarland, C L McGivern, A M McGowan, B Messerly, J Miller, A Mislivec, J G Morfín, J Mousseau, D Naples, J K Nelson, A Norrick, Nuruzzaman, V Paolone, C E Patrick, G N Perdue, M A Ramírez, R D Ransome, H Ray, L Ren, D Rimal, P A Rodrigues, D Ruterbories, D W Schmitz, C J Solano Salinas, M Sultana, S Sánchez Falero, E Valencia, T Walton, J Wolcott, M Wospakrik, B Yaeggy, D Zhang
Neutral-current production of K^{+} by atmospheric neutrinos is a background in searches for the proton decay p→K^{+}ν[over ¯]. Reactions such as νp→νK^{+}Λ are indistinguishable from proton decays when the decay products of the Λ are below detection threshold. Events with K^{+} are identified in MINERvA by reconstructing the timing signature of a K^{+} decay at rest. A sample of 201 neutrino-induced neutral-current K^{+} events is used to measure differential cross sections with respect to the K^{+} kinetic energy, and the non-K^{+} hadronic visible energy...
July 7, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28714065/genotyping-by-sequencing-defines-independent-novel-rhd-variants-for-an-antenatal-patient-and-a-blood-donor
#2
Genghis H Lopez, Eunike C McGowan, Jennifer A Condon, Elizna M Schoeman, Glenda M Millard, Helen O'Brien, Eileen V Roulis, Gorka Ochoa-Garay, Yew-Wah Liew, Robert L Flower, Catherine A Hyland
No abstract text is available yet for this article.
July 16, 2017: Transfusion
https://www.readbyqxmd.com/read/28710350/environmental-surveillance-identifies-multiple-introductions-of-mrsa-cc398-in-an-equine-veterinary-hospital-in-the-uk-2011-2016
#3
Alessio Bortolami, Nicola J Williams, Catherine M McGowan, Padraig G Kelly, Debra C Archer, Michela Corrò, Gina Pinchbeck, Christine J Saunders, Dorina Timofte
Bacterial environmental and surgical site infection (SSI) surveillance was implemented from 2011-2016 in a UK Equine Referral Veterinary Hospital and identified 81 methicillin-resistant Staphylococcus aureus (MRSA) isolates. A cluster of MRSA SSIs occurred in early 2016 with the isolates confirmed as ST398 by multilocus sequence typing (MLST), which prompted retrospective analysis of all MRSA isolates obtained from the environment (n = 62), SSIs (n = 13) and hand plates (n = 6) in the past five years...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28695846/crystal-structure-of-a-%C3%AE-aminopeptidase-from-an-australian-burkholderia-sp
#4
Marietta John-White, Geoff J Dumsday, Priscilla Johanesen, Dena Lyras, Nyssa Drinkwater, Sheena McGowan
β-Aminopeptidases are a unique group of enzymes that have the unusual capability to hydrolyze N-terminal β-amino acids from synthetic β-peptides. β-Peptides can form secondary structures mimicking α-peptide-like structures that are resistant to degradation by most known proteases and peptidases. These characteristics of β-peptides give them great potential as peptidomimetics. Here, the X-ray crystal structure of BcA5-BapA, a β-aminopeptidase from a Gram-negative Burkholderia sp. that was isolated from activated sludge from a wastewater-treatment plant in Australia, is reported...
July 1, 2017: Acta Crystallographica. Section F, Structural Biology Communications
https://www.readbyqxmd.com/read/28694084/olanzapine-reduces-chemotherapy-induced-nausea-and-vomiting-compared-with-aprepitant-in-myeloma-patients-receiving-high-dose-melphalan-before-stem-cell-transplantation-a-retrospective-study
#5
Steven Trifilio, Colleen Welles, Kristin Seeger, Shivani Mehta, MaryAnne Fishman, Katherine McGowan, Kathryn Strejcek, Emily Eiten, Carolyn Pirotte, Elizabeth Lucier, Sean DeFrates, Jayesh Mehta
INTRODUCTION: Acute and delayed chemotherapy-induced nausea and vomiting (CINV) occurs in most patients who receive high-dose melphalan and significantly affects patients' quality of life during autologous stem cell transplantation. Faced with unsatisfactory results using an aprepitant-based regimen, an olanzapine-based regimen was initiated, with the hope of improving the incidence of acute and delayed CINV. A retrospective study was conducted to compare the effectiveness of olanzapine- versus aprepitant-based regimens for CINV prevention in adult hematopoietic stem cell recipients who received high-dose melphalan...
June 20, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28688029/patterns-of-a-rectal-microbicide-placebo-gel-use-in-a-preparatory-stage-for-a-phase-i-trial-among-young-men-who-have-sex-with-men
#6
José A Bauermeister, R Giguere, C S Leu, C Dolezal, I Febo, R D Cranston, K Mayer, I McGowan, A Carballo-Diéguez
We examined young gay, bisexual, and other men who have sex with men's (YGBMSM) usage patterns of a pre-coital, applicator-administered rectal placebo gel. An ethnically diverse sample of 94 YGBMSM (aged 18-30 years) were asked to insert hydroxyethylcellulose placebo gel rectally before receptive anal intercourse (RAI) and report their gel use through an interactive voice response system (IVRS) across 12 weeks. We used trajectory analyses to characterize participants' use of the rectal gel over the 12 weeks, and examine whether these trajectories varied based on participants' sociodemographic characteristics, sexual behaviors, application and insertion behaviors, and experiences using the placebo gel...
July 7, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28680534/nsclc-depend-upon-yap-expression-and-nuclear-localization-after-acquiring-resistance-to-egfr-inhibitors
#7
Marc McGowan, Lilach Kleinberg, Ann Rita Halvorsen, Åslaug Helland, Odd Terje Brustugun
Yes-associated protein (YAP) is a downstream target of the Hippo pathway and has been found to be oncogenic driving many cancers into developing metastatic phenotypes leading to poor survival outcomes. This study investigated if YAP expression is associated with drug resistance in two non-small cell lung cancer (NSCLC) lines (HCC827 and H1975) generated to become resistant to the EGFR tyrosine kinase inhibitors (EGFR TKI) erlotinib, gefitinib or the T790M-specific osimertinib. We found that acquired EGFR TKI resistance was associated with YAP over-expression (osimertinib-resistant cells) or YAP amplification (erlotinib- and gefitinib-resistant cells) along with EMT phenotypic changes...
March 2017: Genes & Cancer
https://www.readbyqxmd.com/read/28678613/identification-of-behaviour-change-techniques-applied-in-interventions-to-improve-cooking-skills-and-food-skills-among-adults
#8
Lynsey Hollywood, Dawn Surgenor, Marla Reiks, Laura McGowan, Fiona Lavelle, Michelle Spence, Monique Raats, Amanda McCloat, Elaine Mooney, Martin Caraher, Moira Dean
BACKGROUND: Cooking and food skills interventions have grown in popularity however there is a lack of transparency as to how these interventions were designed, highlighting a need to identify and understand the mechanisms of behaviour change so that effective components may be introduced in future work. This study critiques cooking and food skills interventions in relation to their design, behaviour change techniques (BCTs), theoretical underpinnings, and outcomes. METHODS: A 40-item CALO-RE taxonomy was used to examine the components of 59 cooking and food skills interventions identified by two systematic reviews...
July 5, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28678438/examining-the-relationship-between-local-extinction-risk-and-position-in-range
#9
Elizabeth H Boakes, Nicholas J B Isaac, Richard A Fuller, Georgina M Mace, Philip J K McGowan
Over half of globally threatened animal species have experienced rapid geographic range loss. Identifying the parts of species' distributions most vulnerable to extinction would benefit conservation planning. However, previous studies give little consensus on whether ranges decline to the core or edge. Here we build on previous work by using empirical data to examine the position of recent local extinctions within species' geographic ranges, addressing range position as a continuum and exploring the influence of environmental factors...
July 5, 2017: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/28673774/development-functional-characterization-and-validation-of-methodology-for-gmp-compliant-manufacture-of-phagocytic-macrophages-a-novel-cellular-therapeutic-for-liver-cirrhosis
#10
Alasdair R Fraser, Chloe Pass, Paul Burgoyne, Anne Atkinson, Laura Bailey, Audrey Laurie, Neil W A McGowan, Akib Hamid, Joanna K Moore, Benjamin J Dwyer, Marc L Turner, Stuart J Forbes, John D M Campbell
BACKGROUND AIMS: Autologous macrophage therapy represents a potentially significant therapeutic advance for the treatment of severe progressive liver cirrhosis. Administration of macrophages has been shown to reduce inflammation and drive fibrotic scar breakdown and tissue repair in relevant models. This therapeutic approach is being assessed for safety and feasibility in a first-in-human trial (MAcrophages Therapy for liver CirrHosis [MATCH] trial). METHODS: We outline the development and validation phases of GMP production...
June 30, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28671847/identification-and-optimization-of-pyrrolo-3-2-d-pyrimidine-toll-like-receptor-7-tlr7-selective-agonists-for-the-treatment-of-hepatitis-b
#11
David C McGowan, Florence Herschke, Frederik Pauwels, Bart Stoops, Ilham Smyej, Stefaan Last, Serge Pieters, Werner Embrechts, Mourad Daoubi Khamlichi, Tine Thoné, Bertrand Van Schoubroeck, Wendy Mostmans, Debbie Wuyts, Dorien Verstappen, Annick Scholliers, Dorien De Pooter, Deborah Dhuyvetter, Herman Borghys, Marianne Tuefferd, Eric Arnoult, Jin Hong, Gregory Fanning, Jacques Bollekens, Vijay Urmaliya, Ard Teisman, Helen Horton, Tim H M Jonckers, Pierre Raboisson
Pyrrolo[3,2-d]pyrimidines were identified as a new series of potent and selective TLR7 agonists. Compounds were optimized for their activity and selectivity over TLR8. This presents an advantage over recently described scaffolds that have residual TLR8 activity, which may be detrimental to the tolerability of the candidate drug. Oral administration of the lead compound 54 effectively induced a transient interferon stimulated gene (ISG) response in mice and cynomolgus monkeys. We aimed for a high first pass effect, limiting cytokine induction systemically, and demonstrated the potential for the immunotherapy of viral hepatitis...
July 27, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28668341/exposure-assessment-using-human-biomonitoring-for-glyphosate-and-fluroxypyr-users-in-amenity-horticulture
#12
Alison Connolly, Kate Jones, Karen S Galea, Ioannis Basinas, Laura Kenny, Padraic McGowan, Marie Coggins
BACKGROUND: Pesticides and their potential adverse health effects are of great concern and there is a dearth of knowledge regarding occupational exposure to pesticides among amenity horticulturalists. OBJECTIVE: This study aims to measure occupational exposures to amenity horticuturalists using pesticides containing the active ingredients, glyphosate and fluroxypyr by urinary biomonitoring. METHODS: A total of 40 work tasks involving glyphosate and fluroxypyr were surveyed over the period of June - October 2015...
June 27, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28656643/risk-factors-for-medication-related-osteonecrosis-of-the-jaws-a-systematic-review
#13
REVIEW
Kelly McGowan, Troy McGowan, Saso Ivanovski
OBJECTIVE: The purpose of this study was to identify the patient populations at risk of medication related osteonecrosis of the jaw (MRONJ) and determine which medical and dental comorbidities are significant risk factors for this disease. METHODS: An electronic search of Embase, MEDLINE, Cochrane Central Register of Controlled Trials, WHO International Clinical Trials Registry Platform and ProQuest Dissertations and Theses Global was conducted to identify all human studies that reported risk factors for MRONJ...
June 28, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28656468/the-role-of-the-built-environment-in-a-randomized-controlled-trial-to-increase-physical-activity-among-men-with-prostate-cancer-the-promote-trial
#14
Erin L McGowan, Daniel Fuller, Nicoleta Cutumisu, Scott North, Kerry S Courneya
PURPOSE: The purpose of the study was to examine the association between the built environment and physical activity (PA) in prostate cancer survivors (PCS), as well as whether built environment factors (walkability, count of sports complexes) were effect modifiers of a PA intervention. METHODS: Our study included 165 PCS residing in Edmonton, Alberta, from the PROMOTE trial. The PROMOTE trial was a randomized controlled trial of a behaviour change intervention to increase PA and quality of life in PCS...
June 27, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28651014/a-decade-of-haart-in-latin-america-long-term-outcomes-among-the-first-wave-of-hiv-patients-to-receive-combination-therapy
#15
Marcelo J Wolff, Mark J Giganti, Claudia P Cortes, Pedro Cahn, Beatriz Grinsztejn, Jean W Pape, Denis Padgett, Juan Sierra-Madero, Eduardo Gotuzzo, Stephany N Duda, Catherine C McGowan, Bryan E Shepherd
BACKGROUND: In Latin America, the first wave of HIV-infected patients initiated highly active antiretroviral therapy (HAART) 10 or more years ago. Characterizing their treatment experience and corresponding outcomes across a decade of HAART may yield insights relevant to the ongoing care of such patients and those initiating HAART more recently in similar clinical settings. METHODS: This retrospective study included adults initiating HAART before 2004 at 8 sites in Argentina, Brazil, Chile, Haiti, Honduras, and Mexico...
2017: PloS One
https://www.readbyqxmd.com/read/28645362/measuring-most-informative-titles-declarative-titles-as-a-knowledge-translation-dissemination-tool-is-possible-using-altmetrics
#16
Jessie McGowan
No abstract text is available yet for this article.
May 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28644546/-18-f-fluoromisonidazole-uptake-in-advanced-stage-non-small-cell-lung-cancer-a-voxel-by-voxel-pet-kinetics-study
#17
Daniel R McGowan, Ruth E Macpherson, Sara L Hackett, Dan Liu, Fergus V Gleeson, W Gillies McKenna, Geoff S Higgins, John D Fenwick
PURPOSE: To determine the relative abilities of compartment models to describe time-courses of 18F-fluoromisonidazole (FMISO) uptake in tumor voxels of patients with non-small cell lung cancer (NSCLC) imaged using dynamic positron emission tomography. Also to use fits of the best-performing model to investigate changes in fitted rate-constants with distance from the tumor edge. METHODS: Reversible and irreversible two- and three-tissue compartment models were fitted to 24,662 individual voxel time activity curves (TACs) obtained from tumors in 9 patients, each imaged twice...
June 23, 2017: Medical Physics
https://www.readbyqxmd.com/read/28622973/maternal-programming-of-sex-specific-responses-to-predator-odor-stress-in-adult-rats
#18
Sophie St-Cyr, Sameera Abuaish, Shathveekan Sivanathan, Patrick O McGowan
Prenatal stress mediated through the mother can lead to long-term adaptations in stress-related phenotypes in offspring. This study tested the long-lasting effect of prenatal exposure to predator odor, an ethologically relevant and psychogenic stressor, in the second half of pregnancy. As adults, the offspring of predator odor-exposed mothers showed increased anxiety-like behaviors in commonly used laboratory tasks assessing novelty-induced anxiety, increased defensive behavior in males and increased ACTH stress reactivity in females in response to predator odor...
June 20, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28618980/evaluating-the-care-cascade-after-antiretroviral-therapy-initiation-in-latin-america
#19
Marcelo J Wolff, Claudia P Cortes, Fernando A Mejìa, Denis Padgett, Pablo Belaunzarán-Zamudio, Beatriz Grinsztejn, Mark J Giganti, Catherine C McGowan, Peter F Rebeiro
Accelerating antiretroviral therapy (ART) administration, improving retention, and achieving viral suppression in low- and middle-income countries must be prioritized. We evaluated trends and disparities in these milestones in a large Latin American cohort. Adults starting ART (ARTstart) from 2003 to 2014 at Caribbean, Central, and South America network for HIV epidemiology sites were assessed for care cascade outcomes: CD4 cell count >200 cells/mm(3) at ARTstart; retention (≥1 visit at one year after ARTstart); viral suppression (≥1 HIV-1 RNA <200 copies/ml at one year after ARTstart)...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28618377/ring-and-peg-electrodes-for-minimally-invasive-and-long-term-sub-scalp-eeg-recordings
#20
Y B Benovitski, A Lai, C C McGowan, O Burns, V Maxim, D A X Nayagam, R Millard, G D Rathbone, M A le Chevoir, R A Williams, D B Grayden, C N May, M Murphy, W J D'Souza, M J Cook, C E Williams
OBJECTIVE: Minimally-invasive approaches are needed for long-term reliable Electroencephalography (EEG) recordings to assist with epilepsy diagnosis, investigation and more naturalistic monitoring. This study compared three methods for long-term implantation of sub-scalp EEG electrodes. METHODS: Three types of electrodes (disk, ring, and peg) were fabricated from biocompatible materials and implanted under the scalp in five ambulatory ewes for 3months. Disk electrodes were inserted into sub-pericranial pockets...
June 12, 2017: Epilepsy Research
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