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https://www.readbyqxmd.com/read/28428239/mds-with-isolated-del-5q-and-internuclear-bridging
#1
Zhaodong Xu, Jean McGowan-Jordan
No abstract text is available yet for this article.
April 20, 2017: Blood
https://www.readbyqxmd.com/read/28426352/the-risky-reading-strategy-revisited-new-simulations-using-e-z-reader
#2
Victoria A McGowan, Erik D Reichle
Eye-movement studies have demonstrated that, relative to college-aged readers, older readers of alphabetic languages like English and German tend to read more slowly, making more frequent, longer fixations, longer saccades, skipping more words, but also making more frequent regressions. These findings have led to suggestions that older readers either adopt a "risky" strategy of using context to "guess" words as a way of compensating for slower rates of lexical processing (Rayner, Reichle, Stroud, Williams, & Pollatsek, 2006), or that they have a smaller and more asymmetrical perceptual span (Laubrock, Kliegl, & Engbert, 2005)...
April 20, 2017: Quarterly Journal of Experimental Psychology: QJEP
https://www.readbyqxmd.com/read/28426284/participatory-genomic-research-ethical-issues-from-the-bottom-up-to-the-top-down
#3
Heide Aungst, Michelle L McGowan, Jennifer R Fishman
Participatory approaches to genomic research manifest along a continuum from bottom-up citizen-science initiatives designed to liberate scientific inquiry from the constraints of traditional research institutional contexts and professional practices to top-down investigator-initiated studies designed to expose the public to scientific research processes and build their support and enthusiasm for genomic research. With foundations as varied as open science, crowdsourcing, patient advocacy, social media, the digitization of health, and the neoliberalization of academic research, a range of ethical frameworks inform the modes of participatory genomic research...
April 19, 2017: Annual Review of Genomics and Human Genetics
https://www.readbyqxmd.com/read/28424917/cubital-tunnel-syndrome-caused-by-ganglion-cysts-a-review-of-59-cases
#4
Jinsong Tong, Bin Xu, Zhen Dong, Jingbo Liu, Chenggang Zhang, Yudong Gu
BACKGROUND: Cubital tunnel syndrome caused by ganglion cysts is rare and reports are few. This study aimed to review a patient cohort with ganglion cysts in the cubital tunnel and identify prognostic factors. METHODS: Fifty-seven patients (59 extremities; McGowan grade I, 4; IIa, 4; IIb, 3; III, 48) were evaluated retrospectively with a minimum follow-up of 2 years. Extraneural cysts were excised completely, while intraneural cysts were incised and drained. All cases underwent subcutaneous transposition...
April 19, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28424149/comparative-safety-of-sulfonylurea-and-metformin-monotherapy-on-the-risk-of-heart-failure-a-cohort-study
#5
Christianne L Roumie, Jea Young Min, Lucy D'Agostino McGowan, Caroline Presley, Carlos G Grijalva, Amber J Hackstadt, Adriana M Hung, Robert A Greevy, Tom Elasy, Marie R Griffin
BACKGROUND: Medications that impact insulin sensitivity or cause weight gain may increase heart failure risk. Our aim was to compare heart failure and cardiovascular death outcomes among patients initiating sulfonylureas for diabetes mellitus treatment versus metformin. METHODS AND RESULTS: National Veterans Health Administration databases were linked to Medicare, Medicaid, and National Death Index data. Veterans aged ≥18 years who initiated metformin or sulfonylureas between 2001 and 2011 and whose creatinine was <1...
April 19, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28418292/lack-of-durable-cross-neutralizing-antibodies-against-zika-virus-from-dengue-virus-infection
#6
Matthew H Collins, Eileen McGowan, Ramesh Jadi, Ellen Young, Cesar A Lopez, Ralph S Baric, Helen M Lazear, Aravinda M de Silva
Cross-reactive antibodies elicited by dengue virus (DENV) infection might affect Zika virus infection and confound serologic tests. Recent data demonstrate neutralization of Zika virus by monoclonal antibodies or human serum collected early after DENV infection. Whether this finding is true in late DENV convalescence (>6 months after infection) is unknown. We studied late convalescent serum samples from persons with prior DENV or Zika virus exposure. Despite extensive cross-reactivity in IgG binding, Zika virus neutralization was not observed among primary DENV infections...
May 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28415564/mammalian-sphingosine-kinase-sphk-isoenzymes-and-isoform-expression-challenges-for-sphk-as-an-oncotarget
#7
REVIEW
Diana Hatoum, Nahal Haddadi, Yiguang Lin, Najah T Nassif, Eileen M McGowan
The various sphingosine kinase (SphK) isoenzymes (isozymes) and isoforms, key players in normal cellular physiology, are strongly implicated in cancer and other diseases. Mutations in SphKs, that may justify abnormal physiological function, have not been recorded. Nonetheless, there is a large and growing body of evidence demonstrating the contribution of gain or loss of function and the imbalance in the SphK/S1P rheostat to a plethora of pathological conditions including cancer, diabetes and inflammatory diseases...
March 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28406653/aging-and-the-optimal-viewing-position-effect-in-visual-word-recognition-evidence-from-english
#8
Lin Li, Sha Li, Jingxin Wang, Victoria A McGowan, Pingping Liu, Timothy R Jordan, Kevin B Paterson
Words are recognized most efficiently by young adults when fixated at an optimal viewing position (OVP), which for English is between a word's beginning and middle letters. How this OVP effect changes with age is unknown but may differ for older adults due to visual declines in later life. Accordingly, a lexical decision experiment was conducted in which short (5-letter) and long (9-letter) words were fixated at various letter positions. The older adults produced slower responses. But, crucially, effects of fixation location for each word-length did not differ substantially across age groups, indicating that OVP effects are preserved in older age...
April 13, 2017: Psychology and Aging
https://www.readbyqxmd.com/read/28398547/patients-preferences-for-anti-osteoporosis-drug-treatment-a-cross-european-discrete-choice-experiment
#9
Mickaël Hiligsmann, Benedict G Dellaert, Carmen D Dirksen, Verity Watson, Sandrine Bours, Stefan Goemaere, Jean-Yves Reginster, Christian Roux, Bernie McGowan, Carmel Silke, Bryan Whelan, Adolfo Diez-Perez, Elisa Torres, Georgios Papadakis, Rene Rizzoli, Cyrus Cooper, Gill Pearson, Annelies Boonen
Objectives.: To estimate the preferences of osteoporotic patients for medication attributes, and analyse data from seven European countries. Methods.: A discrete choice experiment was conducted in Belgium, France, Ireland, the Netherlands, Spain, Switzerland and the UK. Patients were asked to choose repeatedly between two hypothetical unlabelled drug treatments (and an opt-out option) that varied with respect to four attributes: efficacy in reducing the risk of fracture, type of potential common side effects, and mode and frequency of administration...
April 6, 2017: Rheumatology
https://www.readbyqxmd.com/read/28378354/ecological-regime-shift-drives-declining-growth-rates-of-sea-turtles-throughout-the-west-atlantic
#10
Karen A Bjorndal, Alan B Bolten, Milani Chaloupka, Vincent S Saba, Cláudio Bellini, Maria A G Marcovaldi, Armando J B Santos, Luis Felipe Wurdig Bortolon, Anne B Meylan, Peter A Meylan, Jennifer Gray, Robert Hardy, Beth Brost, Michael Bresette, Jonathan C Gorham, Stephen Connett, Barbara Van Sciver Crouchley, Mike Dawson, Deborah Hayes, Carlos E Diez, Robert P van Dam, Sue Willis, Mabel Nava, Kristen M Hart, Michael S Cherkiss, Andrew G Crowder, Clayton Pollock, Zandy Hillis-Starr, Fernando A Muñoz Tenería, Roberto Herrera-Pavón, Vanessa Labrada-Martagón, Armando Lorences, Ana Negrete-Philippe, Margaret M Lamont, Allen M Foley, Rhonda Bailey, Raymond R Carthy, Russell Scarpino, Erin McMichael, Jane A Provancha, Annabelle Brooks, Adriana Jardim, Milagros López-Mendilaharsu, Daniel González-Paredes, Andrés Estrades, Alejandro Fallabrino, Gustavo Martínez-Souza, Gabriela M Vélez-Rubio, Ralf H Boulon, Jaime A Collazo, Robert Wershoven, Vicente Guzmán Hernández, Thomas B Stringell, Amdeep Sanghera, Peter B Richardson, Annette C Broderick, Quinton Phillips, Marta Calosso, John A B Claydon, Tasha L Metz, Amanda L Gordon, Andre M Landry, Donna J Shaver, Janice Blumenthal, Lucy Collyer, Brendan J Godley, Andrew McGowan, Matthew J Witt, Cathi L Campbell, Cynthia J Lagueux, Thomas L Bethel, Lory Kenyon
Somatic growth is an integrated, individual-based response to environmental conditions, especially in ectotherms. Growth dynamics of large, mobile animals are particularly useful as bio-indicators of environmental change at regional scales. We assembled growth rate data from throughout the West Atlantic for green turtles, Chelonia mydas, which are long-lived, highly migratory, primarily herbivorous mega-consumers that may migrate over hundreds to thousands of kilometers. Our dataset, the largest ever compiled for sea turtles, has 9690 growth increments from 30 sites from Bermuda to Uruguay from 1973 to 2015...
April 4, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28369379/localized-twist1-and-twist2-basic-domain-substitutions-cause-four-distinct-human-diseases-that-can-be-modeled-in-c-elegans
#11
Sharon Kim, Stephen R F Twigg, Victoria A Scanlon, Aditi Chandra, Tyler J Hansen, Arwa Alsubait, Aimee L Fenwick, Simon J McGowan, Helen Lord, Tracy Lester, Elizabeth Sweeney, Astrid Weber, Helen Cox, Andrew O M Wilkie, Andy Golden, Ann K Corsi
Twist transcription factors, members of the basic helix-loop-helix family, play crucial roles in mesoderm development in all animals. Humans have two paralogous genes, TWIST1 and TWIST2, and mutations in each gene have been identified in specific craniofacial disorders. Here we describe a new clinical entity, Sweeney-Cox syndrome, associated with distinct de novo amino acid substitutions (p.Glu117Val and p.Glu117Gly) at a highly conserved glutamic acid residue located in the basic DNA binding domain of TWIST1, in two subjects with frontonasal dysplasia and additional malformations...
March 27, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28368780/psychological-predictors-of-eating-pathology-in-older-adult-women
#12
Elizabeth Midlarsky, Ashley Kronen Marotta, Steven Pirutinsky, Ruth T Morin, Joseph C McGowan
Eating pathology is generally considered to affect females during adolescence and early adulthood. However, in recent years, there has been an increased recognition that disordered eating occurs in middle-aged and elderly women and that the presentation is similar to that of eating disorders in younger women. In the research presented here, results of an Internet survey of older adult women (N = 245; aged 60-90 years) indicate that the factors significantly associated with eating pathology-perfectionism, depression, and sociocultural pressures to be thin-closely parallel those reported for both younger and middle-aged women...
April 3, 2017: Journal of Women & Aging
https://www.readbyqxmd.com/read/28364565/how-common-and-frequent-is-heterosexual-anal-intercourse-among-south-africans-a-systematic-review-and-meta-analysis
#13
Branwen N Owen, Jocelyn Elmes, Romain Silhol, Que Dang, Ian McGowan, Barbara Shacklett, Edith M Swann, Ariane van der Straten, Rebecca F Baggaley, Marie-Claude Boily
BACKGROUND: HIV is transmitted more effectively during anal intercourse (AI) than vaginal intercourse (VI). However, patterns of heterosexual AI practice and its contribution to South Africa's generalized epidemic remain unclear. We aimed to determine how common and frequent heterosexual AI is in South Africa. METHODS: We searched for studies reporting the proportion practising heterosexual AI (prevalence) and/or the number of AI and unprotected AI (UAI) acts (frequency) in South Africa from 1990 to 2015...
January 11, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28364561/comprehensiveness-of-hiv-care-provided-at-global-hiv-treatment-sites-in-the-iedea-consortium-2009-and-2014
#14
Cristin Q Fritz, Meridith Blevins, Mary Lou Lindegren, Kara Wools-Kaloutsian, Beverly S Musick, Morna Cornell, Kelly Goodwin, Dianne Addison, Jean Claude Dusingize, Eugène Messou, Armel Poda, Stephany N Duda, Catherine C McGowan, Matthew G Law, Richard D Moore, Aimee Freeman, Denis Nash, C William Wester
INTRODUCTION: An important determinant of the effectiveness of HIV treatment programs is the capacity of sites to implement recommended services and identify systematic changes needed to ensure that invested resources translate into improved patient outcomes. We conducted a survey in 2014 of HIV care and treatment sites in the seven regions of the International epidemiologic Database to Evaluate AIDS (IeDEA) Consortium to evaluate facility characteristics, HIV prevention, care and treatment services provided, laboratory capacity, and trends in the comprehensiveness of care compared to data obtained in the 2009 baseline survey...
January 6, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28363814/the-impact-of-video-technology-on-learning-a-cooking-skills-experiment
#15
Dawn Surgenor, Lynsey Hollywood, Sinéad Furey, Fiona Lavelle, Laura McGowan, Michelle Spence, Monique Raats, Amanda McCloat, Elaine Mooney, Martin Caraher, Moira Dean
This study examines the role of video technology in the development of cooking skills. The study explored the views of 141 female participants on whether video technology can promote confidence in learning new cooking skills to assist in meal preparation. Prior to each focus group participants took part in a cooking experiment to assess the most effective method of learning for low-skilled cooks across four experimental conditions (recipe card only; recipe card plus video demonstration; recipe card plus video demonstration conducted in segmented stages; and recipe card plus video demonstration whereby participants freely accessed video demonstrations as and when needed)...
March 28, 2017: Appetite
https://www.readbyqxmd.com/read/28346672/congenital-bilateral-anterior-nasal-atresia-in-16-half-sibling-holstein-friesian-calves
#16
M McGowan, C Smith, A Ferguson, B Stone, D Vankan, R Allavena
CASE REPORT: Cases of bilateral anterior nasal atresia, sometimes referred to as arhinia or partial arhinia, are extremely rare in cattle and have only been reported as single events. This report describes the birth of 16 Holstein Friesian calves over a 3-month period, all affected with bilateral atresia of the nares and anterior nasal cavity, with 2 calves having additional severe deviation of the nasomaxillary bones and nasal septum. One affected calf was born with an anatomically normal twin...
April 2017: Australian Veterinary Journal
https://www.readbyqxmd.com/read/28338218/evaluation-of-targeted-exome-sequencing-for-28-protein-based-blood-group-systems-including-the-homologous-gene-systems-for-blood-group-genotyping
#17
Elizna M Schoeman, Genghis H Lopez, Eunike C McGowan, Glenda M Millard, Helen O'Brien, Eileen V Roulis, Yew-Wah Liew, Jacqueline R Martin, Kelli A McGrath, Tanya Powley, Robert L Flower, Catherine A Hyland
BACKGROUND: Blood group single nucleotide polymorphism genotyping probes for a limited range of polymorphisms. This study investigated whether massively parallel sequencing (also known as next-generation sequencing), with a targeted exome strategy, provides an extended blood group genotype and the extent to which massively parallel sequencing correctly genotypes in homologous gene systems, such as RH and MNS. STUDY DESIGN AND METHODS: Donor samples (n = 28) that were extensively phenotyped and genotyped using single nucleotide polymorphism typing, were analyzed using the TruSight One Sequencing Panel and MiSeq platform...
March 24, 2017: Transfusion
https://www.readbyqxmd.com/read/28333514/collaborative-family-health-care-civil-rights-and-social-determinants-of-health
#18
Larry B Mauksch, Colleen T Fogarty
Social and economic disadvantage and civil rights infringement, worsens overall health (Adler, Glymour, & Fielding, 2016; McGowan, Lee, Meneses, Perkins, & Youdelman, 2016; Teitelbaum, 2005). While addressing these challenges is not new, there is reason to believe that the administration of Donald Trump and a republican majority in congress will exacerbate these challenges and their effects. How can collaborative family health care (CFHC) practitioners and our field help? The editors pondered this question and also asked a selection of leaders in the field...
March 2017: Families, Systems & Health: the Journal of Collaborative Family Healthcare
https://www.readbyqxmd.com/read/28323947/effects-of-mixed-carotenoids-on-adipokines-and-abdominal-adiposity-in-children-a-pilot-study
#19
J Atilio Canas, Amanda Lochrie, Amy Galena McGowan, Jobayer Hossain, Christopher Schettino, P Babu Balagopal
Context: Carotenoids have been implicated in the regulation of adipocyte metabolism. Objective: To compare the effects of mixed-carotenoid supplementation (MCS) vs. placebo on adipokines and the accrual of abdominal adiposity in children with obesity. Design and Setting: Randomized (1:1) double-blind, placebo-controlled intervention trial to evaluate the effects of MCS over 6 months in a subspecialty clinic. Participants: Twenty (6 male and 14 female) children with simple obesity (BMI > 90%); age: 10...
March 13, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28321895/the-role-of-leptospira-spp-in-horses-affected-with-recurrent-uveitis-in-the-uk
#20
F Malalana, R J Blundell, G L Pinchbeck, C M McGowan
BACKGROUND: Equine Recurrent Uveitis (ERU) is a common cause of ocular pain and blindness in horses. Leptospira spp. have commonly been implicated in the pathophysiology of ERU in mainland Europe and USA. No recent studies have been carried out in the UK but it is reported that Leptospira is not a major factor in the aetiology of ERU in the UK. OBJECTIVES: to establish the prevalence of Leptospira-associated ERU in the UK and identify the serovars involved in these cases in the UK; compare serum versus aqueous humour antibody levels in cases and controls in order to confirm the diagnosis of Leptospira-associated ERU; and assess the usefulness of serology alone as a confirmatory test for Leptospira-associated ERU in the UK...
March 20, 2017: Equine Veterinary Journal
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