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https://www.readbyqxmd.com/read/29782383/genetic-testing-of-xy-newborns-with-a-suspected-disorder-of-sex-development
#1
Malika Alimussina, Louise Ann Diver, Ruth McGowan, Syed Faisal Ahmed
PURPOSE OF REVIEW: The current review focuses on the neonatal presentation of disorders of sex development, summarize the current approach to the evaluation of newborns and describes recent advances in understanding of underlying genetic aetiology of these conditions. RECENT FINDINGS: Several possible candidate genes as well as other adverse environmental factors have been described as contributing to several clinical subgroups of 46,XY DSDs. Moreover, registry-based studies showed that infants with suspected DSD may have extragenital anomalies and in 46,XY cases, being small for gestational age (SGA), cardiac and neurological malformations are the commonest concomitant conditions...
May 17, 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29779959/considering-disability-and-health-reflections-on-the-healthy-people-2020-midcourse-review
#2
Lisa Bundara Sinclair, Michael H Fox, Bruce S Jonas, Hugh G Berry, Louis A Quatrano, Angela K McGowan, Georgina Peacock
The Healthy People 2020 (HP2020) Midcourse Review (MCR) presents an opportunity for professionals in the disability and health field to contemplate preliminary progress toward achieving specific health objectives. The MCR showed notable progress in access to primary care, appropriate services for complex conditions associated with disability, expansion of health promotion programs focusing on disability, improving mental health, and reducing the unemployment rate among job seekers with disabilities. This commentary presents potential considerations, at least in part, for such progress including increased access to health care, greater awareness of appropriate services for complex conditions, and opportunities for societal participation...
April 19, 2018: Disability and Health Journal
https://www.readbyqxmd.com/read/29767639/pharmacokinetics-and-pharmacodynamics-of-tenofovir-reduced-glycerin-1-gel-in-the-rectal-and-vaginal-compartments-in-women-a-cross-compartmental-study-with-directly-observed-dosing
#3
Jessica E Justman, Gonasagrie Lulu Nair, Craig W Hendrix, Jeanna M Piper, Mark A Marzinke, James Y Dai, Zhenyu Pan, Beth Galaska, Lisa Levy, Jill L Schwartz, Bhavna Balar, Ratiya P Kunjara Na Ayudhya, Ivy Mushamiri, Ian McGowan, Charlene S Dezzutti
BACKGROUND: Evidence is lacking regarding whether vaginal pre-exposure prophylaxis with topical tenofovir (TFV) reduces the risk of rectal HIV acquisition. SETTING: Bronx, NY. METHODS: MTN-014 was a phase 1, cross-over, randomized sequence trial comparing the cross-compartment pharmacokinetics and pharmacodynamics of daily TFV reduced-glycerin 1% gel after 14 days each of rectal and vaginal application, with directly observed dosing and a 6-week washout period between phases...
June 1, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29767466/addressing-transboundary-conservation-challenges-through-marine-spatial-prioritization
#4
Elena Gissi, Jennifer McGowan, Chiara Venier, Davide Di Carlo, Francesco Musco, Stefano Menegon, Peter Mackelworth, Tundi Agardy, Hugh Possingham
The Adriatic and Ionian Region (AIR) is an important area for both strategic maritime development and biodiversity conservation in the European Union (EU). However, given that both EU and non-EU countries border the sea, multiple legal and regulatory frameworks operate at different scales which can hinder the coordinated long-term sustainable development of the region. Transboundary marine (or maritime) spatial planning can help overcome these challenges by building consensus on planning objectives and making the trade-offs between biodiversity conservation and its influence on economically important sectors more explicit...
May 16, 2018: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/29761133/the-impact-of-blood-pressure-dipping-status-on-cognition-mobility-and-cardiovascular-health-in-older-adults-following-an-exercise-program
#5
Narlon C Boa Sorte Silva, Michael A Gregory, Dawn P Gill, Cheri L McGowan, Robert J Petrella
Objectives: To determine whether a dual-task gait and aerobic exercise intervention differentially impacted older adults with normal blood pressure (BP) dipping status (dippers) compared to those with nondipping status (nondippers). Methods: This study was a secondary analysis involving participants (mean age = 70.3 years, 61% women) who attended a laboratory-based exercise intervention over a 6-month period (40 min/day and 3 days/week). Participants were assessed in measures of cognition, mobility, and cardiovascular health at baseline, 3, 6, and 12 months (after a 6-month no-contact follow-up)...
January 2018: Gerontology & Geriatric Medicine
https://www.readbyqxmd.com/read/29760767/survival-after-cancer-diagnosis-in-a-cohort-of-hiv-positive-individuals-in-latin-america
#6
Valeria I Fink, Cathy A Jenkins, Jessica L Castilho, Anna K Person, Bryan E Shepherd, Beatriz Grinsztejn, Juliana Netto, Brenda Crabtree-Ramirez, Claudia P Cortés, Denis Padgett, Karu Jayathilake, Catherine McGowan, Pedro Cahn
Background: This study aimed to evaluate trends and predictors of survival after cancer diagnosis in persons living with HIV in the Caribbean, Central, and South America network for HIV epidemiology cohort. Methods: Demographic, cancer, and HIV-related data from HIV-positive adults diagnosed with cancer ≤ 1 year before or any time after HIV diagnosis from January 1, 2000-June 30, 2015 were retrospectively collected. Cancer cases were classified as AIDS-defining cancers (ADC) and non-AIDS-defining cancers (NADC)...
2018: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29758542/fentanyl-self-testing-outside-supervised-injection-settings-to-prevent-opioid-overdose-do-we-know-enough-to-promote-it
#7
Catherine R McGowan, Magdalena Harris, Lucy Platt, Vivian Hope, Tim Rhodes
Since 2013, North America has experienced a sharp increase in unintentional fatal overdoses: fentanyl, and its analogues, are believed to be primarily responsible. Currently, the most practical means for people who use drugs (PWUD) to avoid or mitigate risk of fentanyl-related overdose is to use drugs in the presence of someone who is in possession of, and experienced using, naloxone. Self-test strips which detect fentanyl, and some of its analogues, have been developed for off-label use allowing PWUD to test their drugs prior to consumption...
May 11, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29749028/regional-versus-local-drivers-of-water-quality-in-the-windermere-catchment-lake-district-uk-the-dominant-influence-of-wastewater-pollution-over-the-past-200-years
#8
Heather L Moorhouse, Suzanne McGowan, Zofia E Taranu, Irene Gregory-Eaves, Peter R Leavitt, Matthew D Jones, Philip Barker, Susan A Brayshaw
Freshwater ecosystems are threatened by multiple anthropogenic stressors acting over different spatial and temporal scales, resulting in toxic algal blooms, reduced water quality, and hypoxia. However, while catchment characteristics act as a 'filter' modifying lake response to disturbance, little is known of the relative importance of different drivers and possible differentiation in the response of upland remote lakes in comparison to lowland, impacted lakes. Moreover, many studies have focussed on single lakes rather than looking at responses across a set of individual, yet connected lake basins...
May 10, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29748228/how-to-use-saturation-monitoring-in-newborns
#9
Steven McVea, Michael McGowan, Bharathi Rao
Pulse oximetry is a first-line monitoring tool, used in neonatal medicine routinely as a part of continuous monitoring during intensive care. It is also used to guide response to resuscitation and as a screening tool for congenital heart disease. Despite its widespread use, many healthcare providers are unaware of the underlying principles and limitations of pulse oximetry in neonates. In this article, we will discuss the physiological and technological principles behind the use of saturation monitoring and its use in neonatal practice...
May 10, 2018: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/29747066/spontaneous-dna-damage-to-the-nuclear-genome-promotes-senescence-redox-imbalance-and-aging
#10
Andria R Robinson, Matthew J Yousefzadeh, Tania A Rozgaja, Jin Wang, Xuesen Li, Jeremy S Tilstra, Chelsea H Feldman, Siobhán Q Gregg, Caroline H Johnson, Erin M Skoda, Marie-Céline Frantz, Harris Bell-Temin, Hannah Pope-Varsalona, Aditi U Gurkar, Luigi A Nasto, Renã A S Robinson, Heike Fuhrmann-Stroissnigg, Jolanta Czerwinska, Sara J McGowan, Nadiezhda Cantu-Medellin, Jamie B Harris, Salony Maniar, Mark A Ross, Christy E Trussoni, Nicholas F LaRusso, Eugenia Cifuentes-Pagano, Patrick J Pagano, Barbara Tudek, Nam V Vo, Lora H Rigatti, Patricia L Opresko, Donna B Stolz, Simon C Watkins, Christin E Burd, Claudette M St Croix, Gary Siuzdak, Nathan A Yates, Paul D Robbins, Yinsheng Wang, Peter Wipf, Eric E Kelley, Laura J Niedernhofer
Accumulation of senescent cells over time contributes to aging and age-related diseases. However, what drives senescence in vivo is not clear. Here we used a genetic approach to determine if spontaneous nuclear DNA damage is sufficient to initiate senescence in mammals. Ercc1-/∆ mice with reduced expression of ERCC1-XPF endonuclease have impaired capacity to repair the nuclear genome. Ercc1-/∆ mice accumulated spontaneous, oxidative DNA damage more rapidly than wild-type (WT) mice. As a consequence, senescent cells accumulated more rapidly in Ercc1-/∆ mice compared to repair-competent animals...
April 13, 2018: Redox Biology
https://www.readbyqxmd.com/read/29739408/-care-and-prevent-rationale-for-investigating-skin-and-soft-tissue-infections-and-aa-amyloidosis-among-people-who-inject-drugs-in-london
#11
M Harris, R Brathwaite, Catherine R McGowan, D Ciccarone, G Gilchrist, M McCusker, K O'Brien, J Dunn, J Scott, V Hope
BACKGROUND: Skin and soft tissue infections (SSTIs) are a leading cause of morbidity and mortality among people who inject drugs (PWID). International data indicate up to one third of PWID have experienced an SSTI within the past month. Complications include sepsis, endocarditis and amyloid A (AA) amyloidosis. AA amyloidosis is a serious sequela of chronic SSTI among PWID. Though there is a paucity of literature reporting on AA amyloidosis among PWID, what has been published suggests there is likely a causal relationship between AA amyloidosis and injecting-related SSTI...
May 8, 2018: Harm Reduction Journal
https://www.readbyqxmd.com/read/29737962/perceived-barriers-and-facilitators-to-goals-of-care-discussions-in-the-emergency-department-a-descriptive-analysis-of-the-views-of-emergency-medicine-physicians-and-residents
#12
Niran Argintaru, Kieran L Quinn, Lucas B Chartier, Jacques Lee, Paul Hannam, Erin O'Connor, Leah Steinberg, Howard Ovens, Melissa McGowan, Samuel Vaillancourt
CLINICIAN'S CAPSULE What is known about the topic? Goals of care discussions (GOC) are critical to reflecting patients' preferences in the provision of acute care, yet these discussions can be challenging to have in the emergency department (ED) setting. What did this study ask? What are emergency physicians' perspectives on barriers and facilitators to GOC discussions? What did this study find? In this survey of emergency medicine attending and resident physicians, the majority reported feeling comfortable and adequately trained to conduct GOC discussions...
May 8, 2018: CJEM
https://www.readbyqxmd.com/read/29733739/leadership-capabilities-of-physiotherapy-leaders-in-ireland-part-2-clinical-specialists-and-advanced-physiotherapy-practitioners
#13
E McGowan, N Elliott, E Stokes
BACKGROUND: Investigation of the leadership capabilities of physiotherapy managers found that they report predominantly demonstrating capabilities associated with the human resource and structural frames. However, little is known about the leadership capabilities of clinical specialists and advanced physiotherapy practitioners (APPs) who also are identified as having responsibility for leadership. OBJECTIVE: To explore clinical specialists´ and APPs' perceptions of their leadership capabilities and compare them with the reported leadership capabilities of physiotherapy managers...
May 7, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29733737/leadership-capabilities-of-physiotherapy-leaders-in-ireland-part-1-physiotherapy-managers
#14
Emer McGowan, Naomi Elliott, Emma Stokes
BACKGROUND: Investigation of the leadership capabilities of physiotherapists is needed to allow understanding of current leadership practice and to enable appropriate training programs to be developed. PURPOSE: To explore physiotherapy managers´ perceptions of their leadership capabilities. METHODS: Semi-structured interviews were conducted with a purposive sample of 18 physiotherapy managers from a range of public services and private practices in Ireland...
May 7, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29727458/access-to-antiretroviral-therapy-in-hiv-infected-children-aged-0-19-years-in-the-international-epidemiology-databases-to-evaluate-aids-iedea-global-cohort-consortium-2004-2015-a-prospective-cohort-study
#15
Sophie Desmonde, Franck Tanser, Rachel Vreeman, Elom Takassi, Andrew Edmonds, Pagakrong Lumbiganon, Jorge Pinto, Karen Malateste, Catherine McGowan, Azar Kariminia, Marcel Yotebieng, Fatoumata Dicko, Constantin Yiannoutsos, Mwangelwa Mubiana-Mbewe, Kara Wools-Kaloustian, Mary-Ann Davies, Valériane Leroy
INTRODUCTION: Access to antiretroviral therapy (ART) is a global priority. However, the attrition across the continuum of care for HIV-infected children between their HIV diagnosis and ART initiation is not well known. We analyzed the time from enrollment into HIV care to ART initiation in HIV-infected children within the International Epidemiology Databases to Evaluate AIDS (IeDEA) Global Cohort Consortium. METHODS AND FINDINGS: We included 135,479 HIV-1-infected children, aged 0-19 years and ART-naïve at enrollment, between 1 January 2004 and 31 December 2015, in IeDEA cohorts from Central Africa (3 countries; n = 4,948), East Africa (3 countries; n = 22,827), West Africa (7 countries; n = 7,372), Southern Africa (6 countries; n = 93,799), Asia-Pacific (6 countries; n = 4,045), and Latin America (7 countries; n = 2,488)...
May 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29705530/prevalence-of-beliefs-about-actual-and-mythical-causes-of-cancer-and-their-association-with-socio-demographic-and-health-related-characteristics-findings-from-a-cross-sectional-survey-in-england
#16
Lion Shahab, Jennifer A McGowan, Jo Waller, Samuel G Smith
BACKGROUND: Literature on population awareness about actual causes of cancer is growing but comparatively little is known about the prevalence of people's belief concerning mythical causes of cancer. This study aimed to estimate the prevalence of these beliefs and their association with socio-demographic characteristics and health behaviours. METHODS: A survey containing validated measures of beliefs about actual and mythical cancer causes and health behaviours (smoking, alcohol consumption, physical activity, fruit and vegetable consumption, overweight) was administered to a representative English population sample (N = 1330)...
April 23, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29704944/insulinaemic-and-glycaemic-responses-to-three-forages-in-ponies
#17
H B Carslake, C McG Argo, G L Pinchbeck, A H A Dugdale, C M McGowan
Reduction of the hyperinsulinaemic response to feeding is central to the management of insulin dysregulation (ID). The aim of this study was to compare insulinaemic and glycaemic responses to soaked hay, dry hay and haylage in ponies. Twelve ponies of mixed breeds were maintained under identical management conditions. A randomised four-way crossover trial was conducted, in which fasted animals were fed a meal of 0.25% body weight as dry matter intake soaked hay, dry hay or haylage, or administered an oral glucose test (OGT)...
May 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29704935/epidemiology-of-pituitary-pars-intermedia-dysfunction-a-systematic-literature-review-of-clinical-presentation-disease-prevalence-and-risk-factors
#18
REVIEW
J L Ireland, C M McGowan
Pituitary pars intermedia dysfunction (PPID) is caused by an age-related degenerative disease of dopaminergic neurones. Despite its importance in equine practice, available information regarding its epidemiology is limited. This systematic review aimed to assess published literature to evaluate available evidence regarding the clinical presentation, prevalence and risk factors for PPID in horses and ponies. Electronic database searches were undertaken using a range of terms, and English language publications published prior to August 2016 were included...
May 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29700130/embrace-progress
#19
Kevin Bradley, Daniel R McGowan, Fergus V Gleeson, Geoffrey B Johnson, Jason R Young, Craig S Levin, Guido A Davidzon, Andrei H Iagaru
No abstract text is available yet for this article.
April 26, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29697879/drawing-attention-to-a-neglected-injecting-related-harm-a-systematic-review-of-aa-amyloidosis-among-people-who-inject-drugs
#20
REVIEW
Magdalena Harris, Rachel Brathwaite, Jenny Scott, Gail Gilchrist, Dan Ciccarone, Vivian Hope, Catherine R McGowan
BACKGROUND AND AIMS: Chronic skin and soft tissue infections (SSTI) among people who inject drugs (PWID) can lead to AA-amyloidosis: a serious, yet neglected, multi-organ disease. We aim to synthesise findings on the epidemiology, risk factors, clinical outcomes, screening recommendations, and challenges to treatment for AA-amyloidosis among PWID. METHODS: A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)...
April 26, 2018: Addiction
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