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https://www.readbyqxmd.com/read/29663307/genome-wide-association-study-of-lncrna-polymorphisms-with-bone-mineral-density
#1
Qin Zeng, Ke-Hao Wu, Kun Liu, Yuan Hu, Xiang-Ding Chen, Lei Zhang, Hui Shen, Qin Tian, Lan-Juan Zhao, Hong-Wen Deng, Li-Jun Tan
Recent studies suggested that long noncoding RNAs (lncRNAs) were widely transcribed in the genome, but their potential roles in the genetic complexity of human disorders required further exploration. The purpose of the present study was to explore genetic polymorphisms of lncRNAs associated with bone mineral density (BMD) and its potential value. Based on the lncRNASNP database, 55,906 lncSNPs were selected to conduct a genome-wide association study meta-analysis among 11,140 individuals of seven independent studies for BMDs at femoral neck (FN), lumbar spine, and total hip (HIP)...
April 16, 2018: Annals of Human Genetics
https://www.readbyqxmd.com/read/29662906/quantitative-relationships-between-pulmonary-function-and-residual-neuromuscular-blockade
#2
ShuYing Fu, WenDong Lin, XiNing Zhao, ShengJin Ge, ZhangGang Xue
Background: Neuromuscular blockade is a risk factor for postoperative respiratory weakness during the immediate postoperative period. The quantitative relationships between postoperative pulmonary-function impairment and residual neuromuscular blockade are unknown. Methods: 113 patients who underwent elective laparoscopic cholecystectomy were enrolled in this study. They all had a pulmonary-function test (PFT) during the preoperative evaluation. Predictive values based on demographic data were also recorded...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29662748/national-trends-for-primary-and-revision-lumbar-disc-arthroplasty-throughout-the-united-states
#3
Comron Saifi, Alejandro Cazzulino, Caroline Park, Joseph Laratta, Philip K Louie, Jamal N Shillingford, Ronald Lehman, Howard An, Frank Phillips
Study Design: Retrospective database study. Objectives: Analysis of economic and demographic data concerning lumbar disc arthroplasty (LDA) throughout the United States to improve value-based care and health care utilization. Methods: The National Inpatient Sample database was queried for patients who underwent primary or revision LDA between 2005 and 2013. Demographic and economic data included total surgeries, costs, length of stay, and frequency of routine discharge...
April 2018: Global Spine Journal
https://www.readbyqxmd.com/read/29661495/narcotics-reduction-quality-and-safety-in-gynecologic-oncology-surgery-in-the-first-year-of-enhanced-recovery-after-surgery-protocol-implementation
#4
Jennifer E Bergstrom, Marla E Scott, Yewande Alimi, Ting-Tai Yen, Deborah Hobson, Karime K Machado, Edward J Tanner, Amanda N Fader, Sarah M Temkin, Stephanie Wethington, Kimberly Levinson, Sam Sokolinsky, Brandyn Lau, Rebecca L Stone
OBJECTIVES: Enhanced Recovery After Surgery (ERAS) programs are mechanisms for achieving value-based improvements in surgery. This report provides a detailed analysis of the impact of an ERAS program on patient outcomes as well as quality and safety measures during implementation on a gynecologic oncology service at a major academic medical center. METHODS: A retrospective review of gynecologic oncology patients undergoing elective laparotomy during the implementation phase of an ERAS program (January 2016 through December 2016) was performed...
April 13, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29653061/to-t-test-or-not-to-t-test-a-p-values-based-point-of-view-in-the-receiver-operating-characteristic-curve-framework
#5
Albert Vexler, Jihnhee Yu
A common statistical doctrine supported by many introductory courses and textbooks is that t-test type procedures based on normally distributed data points are anticipated to provide a standard in decision-making. In order to motivate scholars to examine this convention, we introduce a simple approach based on graphical tools of receiver operating characteristic (ROC) curve analysis, a well-established biostatistical methodology. In this context, we propose employing a p-values-based method, taking into account the stochastic nature of p-values...
April 13, 2018: Journal of Computational Biology: a Journal of Computational Molecular Cell Biology
https://www.readbyqxmd.com/read/29652217/forecasting-air-quality-time-series-using-deep-learning
#6
Brian S Freeman, Graham Taylor, Bahram Gharabaghi, Jesse Thé
Implications Novel deep learning techniques were used to train an 8-hour averaged ozone forecast model. Missing data and outliers within the captured data set were replaced using a new imputation method that generated calculated values closer to the expected value based on the time and season. Decision trees were used to identify input variables with the greatest importance. The methods presented in this paper allow air managers to forecast long range air pollution concentration while only monitoring key parameters and without transforming the data set in its entirety, thus allowing real time inputs and continuous prediction...
April 13, 2018: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/29649611/predictors-of-adverse-discharge-disposition-in-adult-spinal-deformity-and-associated-costs
#7
Peter G Passias, Gregory W Poorman, Cole A Bortz, Rabia Qureshi, Bassel G Diebo, Justin C Paul, Samantha R Horn, Frank A Segreto, Alexandra Pyne, Cyrus M Jalai, Virginie Lafage, Shay Bess, Frank J Schwab, Hamid Hassanzadeh
BACKGROUND CONTEXT: With advances in the understanding of adult spinal deformity (ASD), more complex osteotomy and fusion techniques are being implemented with increasing frequency. Patients undergoing ASD corrections infrequently require extended acute care, longer inpatient stays, and are discharged to supervised care. Given the necessity of value-based health care, identification of clinical indicators for adverse discharge disposition in ASD surgeries is paramount. PURPOSE: On nationwide and surgeon-created databases, identify predictors of adverse discharge disposition after ASD surgeries and view corresponding differences in charges...
April 9, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29644010/value-based-genomics
#8
REVIEW
Jun Gong, Kathy Pan, Marwan Fakih, Sumanta Pal, Ravi Salgia
Advancements in next-generation sequencing have greatly enhanced the development of biomarker-driven cancer therapies. The affordability and availability of next-generation sequencers have allowed for the commercialization of next-generation sequencing platforms that have found widespread use for clinical-decision making and research purposes. Despite the greater availability of tumor molecular profiling by next-generation sequencing at our doorsteps, the achievement of value-based care, or improving patient outcomes while reducing overall costs or risks, in the era of precision oncology remains a looming challenge...
March 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29627889/nonenzymatic-determination-of-glucose-at-near-neutral-ph-values-based-on-the-use-of-nafion-and-platinum-black-coated-microneedle-electrode-array
#9
Somasekhar R Chinnadayyala, Ilhwan Park, Sungbo Cho
The authors report on a microneedle-based amperometric nonenzymatic glucose sensor for painless and continuous monitoring of glucose. It consists of 3 × 5 sharp stainless steel microneedles micromachined from a stainless steel substrate. The microneedles are 600 and 100 μm in height and width, respectively. Nafion and platinum black were sequentially coated onto the tip of gold-coated microneedles and used for nonenzymatic (direct) sensing of glucose. Attractive features of the modified microneedle electrode include (a) a low working potential (+0...
April 7, 2018: Mikrochimica Acta
https://www.readbyqxmd.com/read/29626368/patient-centred-value-framework-for-haemophilia
#10
B O'Mahony, G Dolan, D Nugent, C Goodman
INTRODUCTION: Growing budgetary demands have led to increased scrutiny of healthcare spending for rare diseases, leading to a unified goal within the haemophilia community to define objectively patient-centred value in haemophilia care. AIM: To develop a patient-centred outcomes framework with global applicability for assessing value in haemophilia healthcare. METHODS: An international, multidisciplinary panel of experts convened to identify the range of patient impacts of haemophilia health care and organize these into a three-tiered, patient-centred outcomes framework based on Porter's model for assessing value...
April 6, 2018: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/29624190/hospitalist-value-in-an-aco-world
#11
Jing Li, Mark J Williams
The accountable care organization (ACO) concept is advocated as a promising value-based payment model that could successfully realign the current payment system to financially reward improvements in quality and efficiency. Focusing on the care of hospitalized patients and controlling a substantive portion of variable hospital expenses, hospitalists are poised to play an essential role in system-level transformational change to achieve clinical integration. Especially through hospital and health system quality improvement (QI) initiatives, hospitalists can directly impact and share accountability for measures ranging from care coordination to implementation of evidence-based care and the patient and family caregiver experience...
April 2018: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/29624138/the-role-of-academic-health-centres-in-improving-health-equity-a-systematic-review
#12
Alexandra Edelman, Judy Taylor, Pavel V Ovseiko, Stephanie M Topp
Purpose Academic health centres (AHCs) are organisations that pursue a "tripartite" mission to deliver high-quality care to patients, undertake clinical and laboratory research, and train future health professionals. The last decade has seen a global spread of AHC models and a growing interest in the role of AHCs in addressing health system equity. The purpose of this paper is to synthesise and critically appraise the evidence on the role of AHCs in improving health equity. Design/methodology/approach Peer-reviewed and grey literature published in English between 2000 and 2016 were searched...
April 9, 2018: Journal of Health Organization and Management
https://www.readbyqxmd.com/read/29623722/new-visual-field-indices-of-disharmony-for-early-diagnosis-of-glaucoma-alone-or-associated-with-conventional-parameters
#13
Rodrigo Abreu-Gonzalez, Marta Gonzalez-Hernandez, Cristina Pena-Betancor, Paloma Rodriguez-Esteve, Manuel Gonzalez De La Rosa
PURPOSE: To evaluate the specificity of new perimetric indices based on harmony, alone and in combination with structural data, for glaucoma detection. METHODS: In this prospective observational cross-sectional study, one eye of 105 healthy subjects and 97 early and suspect glaucomas were sequentially included and examined with Cirrus optical coherence tomography, twice with OCULUS Smartfield perimeter (SPARK strategy) and twice with Humphrey Analyzer (24-2 SITA-Fast) at the Ophthalmology Department from the University Hospital La Candelaria...
April 1, 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29623619/risk-sharing-agreements-in-the-eu-a-systematic-review-of-major-trends
#14
REVIEW
Trevor Jozef Piatkiewicz, Janine Marie Traulsen, Tove Holm-Larsen
OBJECTIVE: Our objectives were to explore the changes in the level of interest in risk-sharing agreements (RSAs) in the EU during the last 15 years and the underlying reasons for these changes. METHODS: A systematic literature review was conducted using PubMed, Scopus, Web of Science, and Embase. Articles identified were divided into 'quantitative articles' used to establish the level of interest and 'qualitative articles' used to identify the underlying trends in RSAs...
July 18, 2017: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29623034/the-applicability-of-standard-error-of-measurement-and-minimal-detectable-change-to-motor-learning-research-a-behavioral-study
#15
Leonardo Furlan, Annette Sterr
Motor learning studies face the challenge of differentiating between real changes in performance and random measurement error. While the traditional p -value-based analyses of difference (e.g., t -tests, ANOVAs) provide information on the statistical significance of a reported change in performance scores, they do not inform as to the likely cause or origin of that change, that is, the contribution of both real modifications in performance and random measurement error to the reported change. One way of differentiating between real change and random measurement error is through the utilization of the statistics of standard error of measurement (SEM) and minimal detectable change (MDC)...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29622409/optimal-measurement-level-and-ulnar-nerve-cross-sectional-area-cutoff-threshold-for-identifying-ulnar-neuropathy-at-the-elbow-by-mri-and-ultrasonography
#16
Yasushi Terayama, Shigeharu Uchiyama, Kazuhiko Ueda, Nahoko Iwakura, Shota Ikegami, Yoshiharu Kato, Hiroyuki Kato
PURPOSE: Imaging criteria for diagnosing compressive ulnar neuropathy at the elbow (UNE) have recently been established as the maximum ulnar nerve cross-sectional area (UNCSA) upon magnetic resonance imaging (MRI) and/or ultrasonography (US). However, the levels of maximum UNCSA and diagnostic cutoff values have not yet been established. We therefore analyzed UNCSA by MRI and US in patients with UNE and in controls. METHODS: We measured UNCSA at 7 levels in 30 patients with UNE and 28 controls by MRI and at 15 levels in 12 patients with UNE and 24 controls by US...
April 3, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29622138/breast-mr-imaging-in-era-of-value-based-medicine
#17
EDITORIAL
Jessica W T Leung
No abstract text is available yet for this article.
May 2018: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/29621325/stochastic-satisficing-account-of-confidence-in-uncertain-value-based-decisions
#18
Uri Hertz, Bahador Bahrami, Mehdi Keramati
Every day we make choices under uncertainty; choosing what route to work or which queue in a supermarket to take, for example. It is unclear how outcome variance, e.g. uncertainty about waiting time in a queue, affects decisions and confidence when outcome is stochastic and continuous. How does one evaluate and choose between an option with unreliable but high expected reward, and an option with more certain but lower expected reward? Here we used an experimental design where two choices' payoffs took continuous values, to examine the effect of outcome variance on decision and confidence...
2018: PloS One
https://www.readbyqxmd.com/read/29619408/common-sense-in-choice-the-effect-of-sensory-modality-on-neural-value-representations
#19
Anastasia Shuster, Dino J Levy
Although it is well established that the ventromedial prefrontal cortex (vmPFC) represents value using a common currency across categories of rewards, it is unknown whether the vmPFC represents value irrespective of the sensory modality in which alternatives are presented. In the current study, male and female human subjects completed a decision-making task while their neural activity was recorded using functional magnetic resonance imaging. On each trial, subjects chose between a safe alternative and a lottery, which was presented visually or aurally...
March 2018: ENeuro
https://www.readbyqxmd.com/read/29618639/hospital-level-care-coordination-strategies-associated-with-better-patient-experience
#20
Jose F Figueroa, Yevgeniy Feyman, Xiner Zhou, Karen Joynt Maddox
BACKGROUND: Patient experience is a key measure of hospital quality and is increasingly contained in value-based payment programmes. Understanding whether strategies aimed at improving care transitions are associated with better patient experience could help clinical leaders and policymakers seeking to improve care across multiple dimensions. OBJECTIVE: To determine the association of specific hospital care coordination and transition strategies with patient experience...
April 4, 2018: BMJ Quality & Safety
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