Jeffrey A Cohen, Fred D Lublin, Christoper Lock, Daniel Pelletier, Tanuja Chitnis, Munish Mehra, Yael Gothelf, Revital Aricha, Stacy Lindborg, Chaim Lebovits, Yossef Levy, Afsaneh Motamed Khorasani, Ralph Kern
BACKGROUND: Autologous mesenchymal stem cell neurotrophic factor-secreting cells (NurOwn® ) have the potential to modify underlying disease mechanisms in progressive multiple sclerosis (PMS). OBJECTIVE: This open-label phase II study was conducted to evaluate safety/efficacy of three intrathecal cell treatments. METHODS: Eighteen participants with non-relapsing PMS were treated. The primary endpoint was safety. Secondary endpoints included: cerebrospinal fluid (CSF) biomarkers; timed 25-foot walk speed, nine-hole peg test (9-HPT), low-contrast letter acuity, symbol digit modalities test, and 12-item multiple sclerosis (MS) walking scale...
September 14, 2022: Multiple Sclerosis: Clinical and Laboratory Research